{ "directed": true, "multigraph": false, "graph": {}, "nodes": [ { "id": "reaction_10677351", "map_id": "none", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674916", "map_id": "Q54EU4", "name": "AGPAT1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0291332", "map_id": "DDB_G0291332", "name": "AGPAT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677345", "map_id": "none", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674902", "map_id": "none", "name": "Homologues of FASN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869W9", "map_id": "Q869W9", "name": "phospho-pks16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275069", "map_id": "DDB_G0275069", "name": "phospho-pks16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E72", "map_id": "Q55E72", "name": "phospho-stlA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269364", "map_id": "DDB_G0269364", "name": "phospho-stlA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869X2", "map_id": "Q869X2", "name": "phospho-pks17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275077", "map_id": "DDB_G0275077", "name": "phospho-pks17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677349", "map_id": "none", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10677347", "map_id": "Q54J08", "name": "accA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288387", "map_id": "DDB_G0288387", "name": "phospho-accA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696321", "map_id": "none", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10696053", "map_id": "none", "name": "Collagen type XIII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54QY4", "map_id": "Q54QY4", "name": "GlcGalHyl-COL13A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283585", "map_id": "DDB_G0283585", "name": "GlcGalHyl-COL13A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10696319", "map_id": "none", "name": "Collagen alpha-1(XIII) ectodomains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10696293", "map_id": "none", "name": "Cleaved collagen type XIII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10696409", "map_id": "none", "name": "Collagen type XV restin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10696585", "map_id": "none", "name": "Collagen type XIX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697697", "map_id": "none", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697694", "map_id": "none", "name": "Endostatin-degrading cathepsins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O76856", "map_id": "O76856", "name": "ctsD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279411", "map_id": "DDB_G0279411", "name": "ctsD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700000", "map_id": "none", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10692323", "map_id": "Q55E77", "name": "HSPG2(22-4391)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0270488", "map_id": "DDB_G0270488", "name": "HS(6)-AGRN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699995", "map_id": "Q55E77", "name": "HSPG2(22-4196)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10699997", "map_id": "Q55E77", "name": "HSPG2(4197-4391)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10696532", "map_id": "none", "name": "Cathepsin L1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10677776", "map_id": "none", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113592", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677695", "map_id": "none", "name": "MAPK8,9,10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54V83", "map_id": "Q54V83", "name": "MAPK8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280855", "map_id": "DDB_G0280855", "name": "MAPK8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54US6", "map_id": "Q54US6", "name": "MAPK8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42525", "map_id": "P42525", "name": "phospho-erkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286353", "map_id": "DDB_G0286353", "name": "phospho-erkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554L2", "map_id": "Q554L2", "name": "MAPK8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V35", "map_id": "Q54V35", "name": "MAPK8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677763", "map_id": "none", "name": "p-MAPK8,9,10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29370", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677773", "map_id": "none", "name": "p-MAP2K4/p-MAP2K7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HS0", "map_id": "Q54HS0", "name": "MAP2K6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289277", "map_id": "DDB_G0289277", "name": "MAP2K6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721800", "map_id": "none", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685829", "map_id": "none", "name": "hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LU8", "map_id": "Q54LU8", "name": "phospho-p-IRAK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286465", "map_id": "DDB_G0286465", "name": "phospho-p-IRAK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K32", "map_id": "Q86K32", "name": "ube2n", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277267", "map_id": "DDB_G0277267", "name": "ube2n", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D06", "map_id": "Q54D06", "name": "ube2v", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292596", "map_id": "DDB_G0292596", "name": "ube2v", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559R2", "map_id": "Q559R2", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272454", "map_id": "DDB_G0272454", "name": "TRAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680841", "map_id": "none", "name": "UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721798", "map_id": "none", "name": "hp-IRAK1:3xK63polyUb-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710974", "map_id": "none", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689687", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q70GP4", "map_id": "Q70GP4", "name": "phospho-dstB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268638", "map_id": "DDB_G0268638", "name": "phospho-dstB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I20", "map_id": "Q86I20", "name": "phospho-dstD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275167", "map_id": "DDB_G0275167", "name": "phospho-dstD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00910", "map_id": "O00910", "name": "phospho-dstA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281381", "map_id": "DDB_G0281381", "name": "phospho-dstA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BD4", "map_id": "Q54BD4", "name": "phospho-dstC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293532", "map_id": "DDB_G0293532", "name": "phospho-dstC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689719", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722948", "map_id": "none", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722934", "map_id": "none", "name": "2 x p-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722946", "map_id": "none", "name": "2xp-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10711315", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10711313", "map_id": "Q9NKX1", "name": "grp94", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0280057", "map_id": "DDB_G0280057", "name": "grp94", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721951", "map_id": "none", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721937", "map_id": "none", "name": "p-Y693-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721949", "map_id": "none", "name": "Y963-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10711217", "map_id": "none", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711213", "map_id": "none", "name": "p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10711215", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689919", "map_id": "none", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689914", "map_id": "none", "name": "E2 congugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54FR5", "map_id": "Q54FR5", "name": "UBE2E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290629", "map_id": "DDB_G0290629", "name": "UBE2E3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TE1", "map_id": "Q54TE1", "name": "UBE2E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689903", "map_id": "none", "name": "ISG15:UBCH8:ISG15 E3 ligase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94490", "map_id": "Q94490", "name": "ubcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284865", "map_id": "DDB_G0284865", "name": "ubcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CI1", "map_id": "Q54CI1", "name": "ISG15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292984", "map_id": "DDB_G0292984", "name": "ISG15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IK3", "map_id": "Q54IK3", "name": "UBE2Q2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290547", "map_id": "DDB_G0290547", "name": "UBE2Q2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q67", "map_id": "Q54Q67", "name": "HERC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284145", "map_id": "DDB_G0284145", "name": "HERC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XG4", "map_id": "Q54XG4", "name": "RNF19B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292642", "map_id": "DDB_G0292642", "name": "RNF19B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J12", "map_id": "Q54J12", "name": "UBE2Q2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FX4", "map_id": "Q54FX4", "name": "UBE2Q2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689901", "map_id": "none", "name": "ISG15 E3 ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687967", "map_id": "none", "name": "Homologues of UBE2L6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_111294", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76577", "map_id": "CHEBI:456215", "name": "AMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10689916", "map_id": "none", "name": "ISGylated E2 conjugating enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722886", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722870", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722884", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10689924", "map_id": "none", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689905", "map_id": "none", "name": "ISG15:UBA7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55C16", "map_id": "Q55C16", "name": "uba1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270272", "map_id": "DDB_G0270272", "name": "uba1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689897", "map_id": "none", "name": "ISG15:UBCH8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687972", "map_id": "Q55C16", "name": "uba1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10723442", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10685868", "map_id": "Q54GD1", "name": "TXLNA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290231", "map_id": "DDB_G0290231", "name": "TXLNA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682859", "map_id": "none", "name": "Homologues of STX4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54HM5", "map_id": "Q54HM5", "name": "STX1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289379", "map_id": "DDB_G0289379", "name": "STX1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DR2", "map_id": "Q55DR2", "name": "STX1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723440", "map_id": "none", "name": "TXLNA:STX4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54GD1", "map_id": "Q54GD1", "name": "TXLNA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722811", "map_id": "none", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722807", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722797", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722809", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689723", "map_id": "none", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689691", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689721", "map_id": "none", "name": "STAT1/3 homo and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10687013", "map_id": "none", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10687009", "map_id": "none", "name": "Homologues of SUMO1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8N0B4", "map_id": "Q8N0B4", "name": "SUMO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286189", "map_id": "DDB_G0286189", "name": "SUMO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FZ7", "map_id": "Q55FZ7", "name": "UBE2I-G97-SUMO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267886", "map_id": "DDB_G0267886", "name": "UBE2I-G97-SUMO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686997", "map_id": "none", "name": "Homologues of PIAS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q555X5", "map_id": "Q555X5", "name": "pisA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274743", "map_id": "DDB_G0274743", "name": "pisA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V57", "map_id": "Q54V57", "name": "PIAS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280603", "map_id": "DDB_G0280603", "name": "PIAS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686965", "map_id": "none", "name": "p-STAT1 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10687011", "map_id": "none", "name": "p-STAT1 dimer:PIAS:SUMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721796", "map_id": "none", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685818", "map_id": "none", "name": "hp-IRAK1:3xTRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10685820", "map_id": "none", "name": "UBE2N:UBE2V1:K63polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TK0", "map_id": "Q54TK0", "name": "nedd8l1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281703", "map_id": "DDB_G0281703", "name": "nedd8l1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG80", "map_id": "P0CG80", "name": "ubqI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291928", "map_id": "DDB_G0291928", "name": "ubqI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG79", "map_id": "P0CG79", "name": "ubqG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282369", "map_id": "DDB_G0282369", "name": "ubqG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG78", "map_id": "P0CG78", "name": "ubqF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289449", "map_id": "DDB_G0289449", "name": "ubqF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG88", "map_id": "P0CG88", "name": "ubqJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269458", "map_id": "DDB_G0269458", "name": "ubqJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG77", "map_id": "P0CG77", "name": "ubqD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286907", "map_id": "DDB_G0286907", "name": "ubqD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14797", "map_id": "P14797", "name": "ubqC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276765", "map_id": "DDB_G0276765", "name": "ubqC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG81", "map_id": "P0CG81", "name": "ubqH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279721", "map_id": "DDB_G0279721", "name": "ubqH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG76", "map_id": "P0CG76", "name": "ubqA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282295", "map_id": "DDB_G0282295", "name": "ubqA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14794", "map_id": "P14794", "name": "ubqB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280755", "map_id": "DDB_G0280755", "name": "ubqB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685822", "map_id": "none", "name": "hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722845", "map_id": "none", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722843", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685968", "map_id": "none", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685956", "map_id": "none", "name": "MAP2K7,MAP2K4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10685965", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10726042", "map_id": "none", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10726002", "map_id": "Q557F4", "name": "KPNA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0273149", "map_id": "DDB_G0273149", "name": "KPNA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687129", "map_id": "none", "name": "p-Y701-STAT1-1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10726040", "map_id": "none", "name": "p-STAT1 dimer:KPNA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557F4", "map_id": "Q557F4", "name": "KPNA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710976", "map_id": "none", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689683", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721987", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721983", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721985", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721981", "map_id": "none", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721977", "map_id": "none", "name": "p-STAT1:p-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721979", "map_id": "none", "name": "p-Y693-STAT4:p-Y701-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685976", "map_id": "none", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685974", "map_id": "none", "name": "MAP2K3,MAP2K6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10685942", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689693", "map_id": "none", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689685", "map_id": "none", "name": "p-Y701-STAT1, p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685950", "map_id": "none", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685948", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722868", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722866", "map_id": "none", "name": "p-STAT5A,p-STAT5B dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722872", "map_id": "none", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722860", "map_id": "none", "name": "Homologues of p-Y701-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721989", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689689", "map_id": "none", "name": "p-Y701-STAT1: p-Y-705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689717", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10686004", "map_id": "none", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686002", "map_id": "none", "name": "p-MAPK8,9,10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10718623", "map_id": "none", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10718594", "map_id": "Q54MP8", "name": "BRWD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285837", "map_id": "DDB_G0285837", "name": "PHIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718601", "map_id": "O15819", "name": "phospho-H3a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0267402", "map_id": "DDB_G0267402", "name": "H3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718621", "map_id": "none", "name": "BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MP8", "map_id": "Q54MP8", "name": "PHIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O15819", "map_id": "O15819", "name": "H3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685884", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10685874", "map_id": "none", "name": "Homologues of STX1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10685876", "map_id": "none", "name": "TXLNA:STX1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10685882", "map_id": "none", "name": "STXA1:SNAP25,STXBP2, VAMP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54YE6", "map_id": "Q54YE6", "name": "culC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284903", "map_id": "DDB_G0284903", "name": "culC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GB3", "map_id": "Q54GB3", "name": "sybB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290363", "map_id": "DDB_G0290363", "name": "sybB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QC8", "map_id": "Q54QC8", "name": "sec1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283937", "map_id": "DDB_G0283937", "name": "sec1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6TMJ9", "map_id": "Q6TMJ9", "name": "sybA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280061", "map_id": "DDB_G0280061", "name": "sybA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GN5", "map_id": "Q55GN5", "name": "SNAP23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267590", "map_id": "DDB_G0267590", "name": "SNAP23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693415", "map_id": "none", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693390", "map_id": "Q54T63", "name": "EIF4E2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281979", "map_id": "DDB_G0281979", "name": "EIF4E2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10693392", "map_id": "none", "name": "ISGylated 4EHP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T63", "map_id": "Q54T63", "name": "EIF4E2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685832", "map_id": "none", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10722864", "map_id": "none", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722862", "map_id": "none", "name": "p-Y-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693413", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693409", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55D61", "map_id": "Q55D61", "name": "tifA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269192", "map_id": "DDB_G0269192", "name": "tifA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553R3", "map_id": "Q553R3", "name": "eif4g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275395", "map_id": "DDB_G0275395", "name": "eif4g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90529", "map_id": "P90529", "name": "ifdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269146", "map_id": "DDB_G0269146", "name": "ifdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FE0", "map_id": "Q55FE0", "name": "eif4e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268574", "map_id": "DDB_G0268574", "name": "eif4e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BQ5", "map_id": "Q55BQ5", "name": "EIF4E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270406", "map_id": "DDB_G0270406", "name": "EIF4E3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10693411", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10693407", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686967", "map_id": "none", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10686953", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722952", "map_id": "none", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722932", "map_id": "none", "name": "Homologues of p-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685932", "map_id": "none", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685816", "map_id": "none", "name": "p-2S,S376,T,T209,T387-IRAK1:TRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10685814", "map_id": "Q559R2", "name": "TRAF6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680392", "map_id": "none", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10680378", "map_id": "none", "name": "p-T1218, Y220 MAPK7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113550", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10680382", "map_id": "none", "name": "MAPK7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10680389", "map_id": "none", "name": "PP2A-ABdeltaC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XZE5", "map_id": "Q9XZE5", "name": "pho2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290263", "map_id": "DDB_G0290263", "name": "pho2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR9", "map_id": "Q54QR9", "name": "pppA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283601", "map_id": "DDB_G0283601", "name": "pppA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VB6", "map_id": "Q54VB6", "name": "psrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280469", "map_id": "DDB_G0280469", "name": "psrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718598", "map_id": "none", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698721", "map_id": "Q55C32", "name": "SMARCA4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285205", "map_id": "DDB_G0285205", "name": "SMARCA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718596", "map_id": "none", "name": "BRWD1:SMARCA4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55C32", "map_id": "Q55C32", "name": "SMARCA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10689908", "map_id": "none", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687957", "map_id": "Q54CI1", "name": "ISG15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10721991", "map_id": "none", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721935", "map_id": "none", "name": "Homologues of p-Y693-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686171", "map_id": "none", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686160", "map_id": "none", "name": "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686168", "map_id": "none", "name": "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722999", "map_id": "none", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683071", "map_id": "none", "name": "Homologues of STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10711221", "map_id": "none", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711219", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721993", "map_id": "none", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10722966", "map_id": "none", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722920", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722964", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10711033", "map_id": "none", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711027", "map_id": "none", "name": "p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10711031", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y614-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721995", "map_id": "none", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687127", "map_id": "none", "name": "Homologues of p-Y701-STAT1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722989", "map_id": "none", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10677669", "map_id": "none", "name": "Homologues of MAPK8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677717", "map_id": "none", "name": "Homologues of p-T,Y-MAPK8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689912", "map_id": "none", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10688804", "map_id": "none", "name": "Homologues of NEDD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QF1", "map_id": "Q54QF1", "name": "HECW2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283983", "map_id": "DDB_G0283983", "name": "HECW2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G034", "map_id": "C7G034", "name": "HUWE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285063", "map_id": "DDB_G0285063", "name": "HUWE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689910", "map_id": "none", "name": "ISG15:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689954", "map_id": "none", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689950", "map_id": "none", "name": "ISG15 targets", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1M9", "map_id": "Q9U1M9", "name": "dymB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277851", "map_id": "DDB_G0277851", "name": "dymB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G083", "map_id": "C7G083", "name": "EIF2AK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295843", "map_id": "DDB_G0295843", "name": "EIF2AK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F45", "map_id": "Q55F45", "name": "EIF2AK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DK2", "map_id": "Q55DK2", "name": "EIF2AK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94464", "map_id": "Q94464", "name": "dymA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277849", "map_id": "DDB_G0277849", "name": "dymA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L44", "map_id": "Q86L44", "name": "helF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294407", "map_id": "DDB_G0294407", "name": "helF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R98", "map_id": "Q54R98", "name": "EIF2AK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689952", "map_id": "none", "name": "ISGylated host proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693385", "map_id": "none", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_141681", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693382", "map_id": "none", "name": "USP18-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54H96", "map_id": "Q54H96", "name": "USP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289611", "map_id": "DDB_G0289611", "name": "USP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711065", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711063", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10723438", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10723434", "map_id": "none", "name": "Homologues of STX3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723436", "map_id": "none", "name": "TXLNA:STX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10689921", "map_id": "none", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10681044", "map_id": "none", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10681041", "map_id": "none", "name": "ERK-specific DUSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CK7", "map_id": "Q54CK7", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292880", "map_id": "DDB_G0292880", "name": "DUSP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CS8", "map_id": "Q55CS8", "name": "mpl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270688", "map_id": "DDB_G0270688", "name": "mpl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CS7", "map_id": "Q55CS7", "name": "mpl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269918", "map_id": "DDB_G0269918", "name": "mpl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T813", "map_id": "Q8T813", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N84", "map_id": "Q54N84", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BI8", "map_id": "Q55BI8", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Y8", "map_id": "Q556Y8", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722922", "map_id": "none", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721965", "map_id": "none", "name": "Homologues of p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700120", "map_id": "none", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10700111", "map_id": "none", "name": "RAC1:GTP:PAK1 dimer:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34144", "map_id": "P34144", "name": "rac1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277869", "map_id": "DDB_G0277869", "name": "rac1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29438", "map_id": "CHEBI:37565", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55GV3", "map_id": "Q55GV3", "name": "pakC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267450", "map_id": "DDB_G0267450", "name": "pakC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700117", "map_id": "none", "name": "RAC1-GTP:p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10700113", "map_id": "none", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10681384", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10683631", "map_id": "none", "name": "PAK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680511", "map_id": "none", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76183", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674849", "map_id": "Q54J08", "name": "accA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10686784", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_70106", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29364", "map_id": "CHEBI:57783", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29366", "map_id": "CHEBI:58349", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686781", "map_id": "none", "name": "HSD17B3,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q869Y3", "map_id": "Q869Y3", "name": "HSD17B3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275049", "map_id": "DDB_G0275049", "name": "HSD17B3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686779", "map_id": "none", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548794", "map_id": "CHEBI:15527", "name": "ICS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76194", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548829", "map_id": "CHEBI:52328", "name": "3ODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686774", "map_id": "none", "name": "Homologues of ELOVL7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "C7FZW5", "map_id": "C7FZW5", "name": "ELOVL5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271066", "map_id": "DDB_G0271066", "name": "ELOVL5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BY4", "map_id": "Q55BY4", "name": "ELOVL5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680602", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29356", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680599", "map_id": "none", "name": "ACSL1,3,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54JK0", "map_id": "Q54JK0", "name": "ACSL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288001", "map_id": "DDB_G0288001", "name": "ACSL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DR6", "map_id": "Q55DR6", "name": "fcsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269242", "map_id": "DDB_G0269242", "name": "fcsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXQ4", "map_id": "Q1ZXQ4", "name": "fcsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269474", "map_id": "DDB_G0269474", "name": "fcsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718402", "map_id": "none", "name": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8862377", "map_id": "CHEBI:84646", "name": "3OA-ACP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8862371", "map_id": "CHEBI:84648", "name": "3HA-ACP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10718399", "map_id": "none", "name": "2xHSD17B8:2xCBR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q75JT8", "map_id": "Q75JT8", "name": "HSD17B8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272154", "map_id": "DDB_G0272154", "name": "HSD17B8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E82", "map_id": "Q55E82", "name": "CBR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269356", "map_id": "DDB_G0269356", "name": "CBR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710291", "map_id": "none", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695985", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5695971", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710288", "map_id": "none", "name": "ACSBG1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CD5", "map_id": "Q55CD5", "name": "ACSBG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270106", "map_id": "DDB_G0270106", "name": "ACSBG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686794", "map_id": "none", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548809", "map_id": "CHEBI:50570", "name": "TOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686789", "map_id": "Q55C17", "name": "gpsn2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0270270", "map_id": "DDB_G0270270", "name": "gpsn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674838", "map_id": "none", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674835", "map_id": "none", "name": "ACLY tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YA0", "map_id": "Q54YA0", "name": "acly", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278345", "map_id": "DDB_G0278345", "name": "acly", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677353", "map_id": "none", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674904", "map_id": "none", "name": "FASN dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10709494", "map_id": "none", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_5690533", "map_id": "none", "name": "PALM:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_6785219", "map_id": "CHEBI:36080", "name": "protein", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_400452", "map_id": "CHEBI:15756", "name": "PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5690516", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10709491", "map_id": "Q54N35", "name": "PPT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0288807", "map_id": "DDB_G0288807", "name": "PPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710299", "map_id": "none", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29374", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696008", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159448", "map_id": "CHEBI:456215", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696003", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159450", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10710296", "map_id": "Q54HD3", "name": "ACSF3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0289539", "map_id": "DDB_G0289539", "name": "ACSF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686768", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686765", "map_id": "none", "name": "ELOVL1,2,3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10674907", "map_id": "none", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10686777", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10709097", "map_id": "none", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_5690537", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678675", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10709094", "map_id": "none", "name": "Homologues of PPT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54N35", "map_id": "Q54N35", "name": "PPT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IE5", "map_id": "Q54IE5", "name": "PPT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722585", "map_id": "none", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8957387", "map_id": "CHEBI:15456", "name": "3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8957386", "map_id": "CHEBI:50998", "name": "t2E-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10722582", "map_id": "Q54T75", "name": "HTD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0281965", "map_id": "DDB_G0281965", "name": "HTD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704723", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10704720", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54YR9", "map_id": "Q54YR9", "name": "PTPLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278113", "map_id": "DDB_G0278113", "name": "PTPLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y54", "map_id": "Q54Y54", "name": "PTPLAD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278683", "map_id": "DDB_G0278683", "name": "PTPLAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723486", "map_id": "none", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351990", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9014643", "map_id": "CHEBI:58020", "name": "2AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10723483", "map_id": "none", "name": "PXLP-SDS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86B06", "map_id": "Q86B06", "name": "sds", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272787", "map_id": "DDB_G0272787", "name": "sds", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723494", "map_id": "none", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936714", "map_id": "CHEBI:30831", "name": "2OBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10723491", "map_id": "Q86KR5", "name": "Q86KR5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277761", "map_id": "DDB_G0277761", "name": "Q86KR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724544", "map_id": "none", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10724541", "map_id": "none", "name": "RAP1:GTP:B-Raf complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "P54632", "map_id": "P54632", "name": "fttB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269138", "map_id": "DDB_G0269138", "name": "fttB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54HC6", "map_id": "Q54HC6", "name": "phospho-arkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289555", "map_id": "DDB_G0289555", "name": "phospho-arkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HG9", "map_id": "Q86HG9", "name": "phospho-p-S166-RIPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278535", "map_id": "DDB_G0278535", "name": "phospho-p-S166-RIPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TM7", "map_id": "Q54TM7", "name": "phospho-drkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281557", "map_id": "DDB_G0281557", "name": "phospho-drkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XX5", "map_id": "Q54XX5", "name": "phospho-p-S166-RIPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L51", "map_id": "Q86L51", "name": "rapB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272857", "map_id": "DDB_G0272857", "name": "rapB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18613", "map_id": "P18613", "name": "rapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291237", "map_id": "DDB_G0291237", "name": "rapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BW0", "map_id": "Q55BW0", "name": "rapC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270340", "map_id": "DDB_G0270340", "name": "rapC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724523", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10680187", "map_id": "none", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10680183", "map_id": "P42525", "name": "phospho-erkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680185", "map_id": "P42525", "name": "phospho-erkA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10724539", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724527", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10724536", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10678590", "map_id": "none", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678586", "map_id": "none", "name": "Homologues of RALGDS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SSQ3", "map_id": "Q8SSQ3", "name": "phospho-gefM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274607", "map_id": "DDB_G0274607", "name": "phospho-gefM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FF3", "map_id": "Q54FF3", "name": "phospho-gefK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290901", "map_id": "DDB_G0290901", "name": "phospho-gefK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS15", "map_id": "Q8IS15", "name": "phospho-gefI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277915", "map_id": "DDB_G0277915", "name": "phospho-gefI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86G47", "map_id": "Q86G47", "name": "phospho-gefQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289665", "map_id": "DDB_G0289665", "name": "phospho-gefQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS16", "map_id": "Q8IS16", "name": "phospho-gefH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276963", "map_id": "DDB_G0276963", "name": "phospho-gefH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS14", "map_id": "Q8IS14", "name": "phospho-gefJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277913", "map_id": "DDB_G0277913", "name": "phospho-gefJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L90", "map_id": "Q54L90", "name": "phospho-gflB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286773", "map_id": "DDB_G0286773", "name": "phospho-gflB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS20", "map_id": "Q8IS20", "name": "phospho-gefC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282381", "map_id": "DDB_G0282381", "name": "phospho-gefC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS19", "map_id": "Q8IS19", "name": "phospho-gefD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289667", "map_id": "DDB_G0289667", "name": "phospho-gefD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS18", "map_id": "Q8IS18", "name": "phospho-gefE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269252", "map_id": "DDB_G0269252", "name": "phospho-gefE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FD8", "map_id": "Q55FD8", "name": "phospho-gefV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268578", "map_id": "DDB_G0268578", "name": "phospho-gefV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSQ0", "map_id": "Q8SSQ0", "name": "phospho-gefR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274605", "map_id": "DDB_G0274605", "name": "phospho-gefR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XL4", "map_id": "Q54XL4", "name": "phospho-p-T133-RASGRP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289613", "map_id": "DDB_G0289613", "name": "phospho-p-T133-RASGRP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TK8", "map_id": "Q54TK8", "name": "phospho-gefP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281573", "map_id": "DDB_G0281573", "name": "phospho-gefP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0P8", "map_id": "B0M0P8", "name": "phospho-gefL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276371", "map_id": "DDB_G0276371", "name": "phospho-gefL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS21", "map_id": "Q8IS21", "name": "phospho-gefB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269222", "map_id": "DDB_G0269222", "name": "phospho-gefB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ST25", "map_id": "Q8ST25", "name": "phospho-gefG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272032", "map_id": "DDB_G0272032", "name": "phospho-gefG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C94", "map_id": "Q54C94", "name": "phospho-gefF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293006", "map_id": "DDB_G0293006", "name": "phospho-gefF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552M5", "map_id": "Q552M5", "name": "phospho-gefY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276019", "map_id": "DDB_G0276019", "name": "phospho-gefY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ4", "map_id": "Q54PQ4", "name": "phospho-gefA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284329", "map_id": "DDB_G0284329", "name": "phospho-gefA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSW7", "map_id": "Q8SSW7", "name": "phospho-gefS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271868", "map_id": "DDB_G0271868", "name": "phospho-gefS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WL2", "map_id": "Q54WL2", "name": "phospho-p-T133-RASGRP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H95", "map_id": "Q54H95", "name": "phospho-p-T133-RASGRP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS12", "map_id": "Q8IS12", "name": "phospho-gefN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275703", "map_id": "DDB_G0275703", "name": "phospho-gefN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS11", "map_id": "Q8IS11", "name": "phospho-gefO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290267", "map_id": "DDB_G0290267", "name": "phospho-gefO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GH9", "map_id": "Q55GH9", "name": "phospho-gefW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267666", "map_id": "DDB_G0267666", "name": "phospho-gefW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678454", "map_id": "none", "name": "p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54U62", "map_id": "Q54U62", "name": "rsmB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281253", "map_id": "DDB_G0281253", "name": "rsmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32254", "map_id": "P32254", "name": "rasS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283537", "map_id": "DDB_G0283537", "name": "rasS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32252", "map_id": "P32252", "name": "rasB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292998", "map_id": "DDB_G0292998", "name": "rasB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXQ0", "map_id": "Q1ZXQ0", "name": "phr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270932", "map_id": "DDB_G0270932", "name": "phr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32253", "map_id": "P32253", "name": "rasC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281385", "map_id": "DDB_G0281385", "name": "rasC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VD5", "map_id": "Q54VD5", "name": "S-Farn-Me-2xPalmS HRAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280437", "map_id": "DDB_G0280437", "name": "S-Farn-Me-2xPalmS HRAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15064", "map_id": "P15064", "name": "rasG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293434", "map_id": "DDB_G0293434", "name": "rasG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P03967", "map_id": "P03967", "name": "rasD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292996", "map_id": "DDB_G0292996", "name": "rasD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75J93", "map_id": "Q75J93", "name": "cpras1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277381", "map_id": "DDB_G0277381", "name": "cpras1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678588", "map_id": "none", "name": "Ras-GTP:RalGDS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724534", "map_id": "none", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10724525", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10724561", "map_id": "none", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10724549", "map_id": "Q54TY7", "name": "srfA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281387", "map_id": "DDB_G0281387", "name": "phospho-srfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10724552", "map_id": "Q54TY7", "name": "phospho-srfA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10724558", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54IF2", "map_id": "Q54IF2", "name": "phospho-p-T256,S422-SGK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288795", "map_id": "DDB_G0288795", "name": "phospho-p-T256,S422-SGK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54644", "map_id": "P54644", "name": "phospho-pkbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268620", "map_id": "DDB_G0268620", "name": "phospho-pkbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724023", "map_id": "none", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025012", "map_id": "CHEBI:140220", "name": "14(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026307", "map_id": "CHEBI:140200", "name": "13,14(S)-epoxy-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696157", "map_id": "none", "name": "ALOX12:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86H96", "map_id": "Q86H96", "name": "ALOX12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275577", "map_id": "DDB_G0275577", "name": "ALOX12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q54W35", "map_id": "Q54W35", "name": "lipA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279909", "map_id": "DDB_G0279909", "name": "lipA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724019", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29368", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026293", "map_id": "CHEBI:140222", "name": "14(S)-Hp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026311", "map_id": "CHEBI:140258", "name": "MaR3n-3 DPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684976", "map_id": "Q54W35", "name": "lipA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10724021", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9608444", "map_id": "CHEBI:53488", "name": "DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10692055", "map_id": "none", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680794", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O00897", "map_id": "O00897", "name": "calB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269104", "map_id": "DDB_G0269104", "name": "calB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_74016", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_71185", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q7Z2B8", "map_id": "Q7Z2B8", "name": "mlcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277917", "map_id": "DDB_G0277917", "name": "mlcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54L96", "map_id": "Q54L96", "name": "NOS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286763", "map_id": "DDB_G0286763", "name": "NOS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02599", "map_id": "P02599", "name": "calA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279407", "map_id": "DDB_G0279407", "name": "calA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76629", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55CT1", "map_id": "Q55CT1", "name": "redB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269912", "map_id": "DDB_G0269912", "name": "redB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54651", "map_id": "P54651", "name": "hspD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267400", "map_id": "DDB_G0267400", "name": "hspD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692053", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10680817", "map_id": "none", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680768", "map_id": "none", "name": "eNOS:CaM:HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10680089", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680776", "map_id": "none", "name": "eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10680970", "map_id": "none", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10680934", "map_id": "none", "name": "Homologues of 2xPalmC-MyrG-NOS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10680751", "map_id": "none", "name": "palmitoylated, myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10680960", "map_id": "none", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_76168", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_10680805", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680957", "map_id": "none", "name": "LYPLA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T49", "map_id": "Q54T49", "name": "LYPLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282005", "map_id": "DDB_G0282005", "name": "LYPLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692058", "map_id": "none", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680792", "map_id": "none", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680790", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10692064", "map_id": "none", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497811", "map_id": "CHEBI:16095", "name": "sepiapterin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691609", "map_id": "none", "name": "p-SPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GP3", "map_id": "Q54GP3", "name": "phospho-sprA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290009", "map_id": "DDB_G0290009", "name": "phospho-sprA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680815", "map_id": "none", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10680813", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10680942", "map_id": "none", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10680803", "map_id": "none", "name": "Homologues of MyrG-NOS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680939", "map_id": "Q54YH2", "name": "ZDHHC21", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0278239", "map_id": "DDB_G0278239", "name": "ZDHHC21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692051", "map_id": "none", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680797", "map_id": "none", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5693375", "map_id": "CHEBI:25682", "name": "ADMA", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680950", "map_id": "none", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_184174", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680948", "map_id": "none", "name": "Homologues of NOS3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685205", "map_id": "none", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429974", "map_id": "none", "name": "mature mRNA (eukaryotic, capped and deadenylated)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109395", "map_id": "CHEBI:60377", "name": "CMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109402", "map_id": "CHEBI:57865", "name": "UMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_429926", "map_id": "none", "name": "capped oligoribonucleotide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113578", "map_id": "CHEBI:58115", "name": "GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10685202", "map_id": "none", "name": "Exosome:SKI complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KWX9", "map_id": "Q7KWX9", "name": "exosc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276783", "map_id": "DDB_G0276783", "name": "exosc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QJ0", "map_id": "Q54QJ0", "name": "HBS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283769", "map_id": "DDB_G0283769", "name": "HBS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HV0", "map_id": "Q54HV0", "name": "DG1091", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289175", "map_id": "DDB_G0289175", "name": "DG1091", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EU6", "map_id": "Q54EU6", "name": "EXOSC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291328", "map_id": "DDB_G0291328", "name": "EXOSC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BH9", "map_id": "Q54BH9", "name": "DIS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293614", "map_id": "DDB_G0293614", "name": "DIS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BB0", "map_id": "Q55BB0", "name": "EXOSC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271396", "map_id": "DDB_G0271396", "name": "EXOSC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N99", "map_id": "Q54N99", "name": "EXOSC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285377", "map_id": "DDB_G0285377", "name": "EXOSC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q83", "map_id": "Q54Q83", "name": "EXOSC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284053", "map_id": "DDB_G0284053", "name": "EXOSC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BJ2", "map_id": "Q55BJ2", "name": "EXOSC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271100", "map_id": "DDB_G0271100", "name": "EXOSC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CU6", "map_id": "Q54CU6", "name": "EXOSC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292692", "map_id": "DDB_G0292692", "name": "EXOSC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K90", "map_id": "Q86K90", "name": "SKIV2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277211", "map_id": "DDB_G0277211", "name": "SKIV2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EV5", "map_id": "Q54EV5", "name": "EXOSC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291310", "map_id": "DDB_G0291310", "name": "EXOSC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S59", "map_id": "Q54S59", "name": "wdr61", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282793", "map_id": "DDB_G0282793", "name": "wdr61", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VM4", "map_id": "Q54VM4", "name": "exosc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280251", "map_id": "DDB_G0280251", "name": "exosc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690044", "map_id": "none", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690036", "map_id": "Q55FN5", "name": "hdaA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268024", "map_id": "DDB_G0268024", "name": "hdaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690021", "map_id": "none", "name": "RBL1:E2F4:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7KWP1", "map_id": "Q7KWP1", "name": "TFDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276799", "map_id": "DDB_G0276799", "name": "TFDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q23", "map_id": "Q54Q23", "name": "phospho-p-S12-E2F6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284129", "map_id": "DDB_G0284129", "name": "phospho-p-S12-E2F6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FX2", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290551", "map_id": "DDB_G0290551", "name": "phospho-rblA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690042", "map_id": "none", "name": "HDAC1:RBL1:E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55FN5", "map_id": "Q55FN5", "name": "hdaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690384", "map_id": "none", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690372", "map_id": "none", "name": "Cyclin E/A:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34112", "map_id": "P34112", "name": "phospho-cdk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272813", "map_id": "DDB_G0272813", "name": "phospho-cdk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2F2", "map_id": "Q8T2F2", "name": "CCNF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277439", "map_id": "DDB_G0277439", "name": "CCNF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXI1", "map_id": "Q1ZXI1", "name": "cycA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279085", "map_id": "DDB_G0279085", "name": "cycA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690382", "map_id": "none", "name": "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10690040", "map_id": "none", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690008", "map_id": "none", "name": "RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10690038", "map_id": "none", "name": "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10690376", "map_id": "none", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690374", "map_id": "none", "name": "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10690388", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690019", "map_id": "Q54FX2", "name": "rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10690386", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10690380", "map_id": "none", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10689991", "map_id": "Q54FX2", "name": "rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10690378", "map_id": "none", "name": "RBL2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679987", "map_id": "none", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679984", "map_id": "none", "name": "2xENPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54MJ8", "map_id": "Q54MJ8", "name": "ENPP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285897", "map_id": "DDB_G0285897", "name": "ENPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679977", "map_id": "none", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679974", "map_id": "Q54RS3", "name": "FLAD1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282955", "map_id": "DDB_G0282955", "name": "FLAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701666", "map_id": "none", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_5221122", "map_id": "CHEBI:29089", "name": "1,2-diacyl-glycerol 3-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10700336", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q75JA1", "map_id": "Q75JA1", "name": "LPIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271730", "map_id": "DDB_G0271730", "name": "LPIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699545", "map_id": "none", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699541", "map_id": "none", "name": "HSP40:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VQ1", "map_id": "Q54VQ1", "name": "ddj1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280037", "map_id": "DDB_G0280037", "name": "ddj1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ED3", "map_id": "Q54ED3", "name": "dnaja1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291568", "map_id": "DDB_G0291568", "name": "dnaja1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699543", "map_id": "none", "name": "HSP70:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557E0", "map_id": "Q557E0", "name": "hspE-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273249", "map_id": "DDB_G0273249", "name": "hspE-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BE0", "map_id": "Q54BE0", "name": "HSPA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293678", "map_id": "DDB_G0293678", "name": "HSPA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BD8", "map_id": "Q54BD8", "name": "HSPA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36415", "map_id": "P36415", "name": "hspB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269144", "map_id": "DDB_G0269144", "name": "hspB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699415", "map_id": "none", "name": "HSP40:HSP70:ATP:nascent protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10702418", "map_id": "none", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699485", "map_id": "none", "name": "HSP90:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DA8", "map_id": "Q54DA8", "name": "sti1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292404", "map_id": "DDB_G0292404", "name": "sti1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702412", "map_id": "none", "name": "HSP90:ATP:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699420", "map_id": "none", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699417", "map_id": "none", "name": "HSP40:HSP70:ADP:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699413", "map_id": "none", "name": "HSP40s", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699487", "map_id": "none", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699479", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699473", "map_id": "Q54DA8", "name": "sti1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10678193", "map_id": "none", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10678182", "map_id": "none", "name": "ETF:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "Q54YZ4", "map_id": "Q54YZ4", "name": "etfb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277991", "map_id": "DDB_G0277991", "name": "etfb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FD7", "map_id": "Q54FD7", "name": "etfa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290927", "map_id": "DDB_G0290927", "name": "etfa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_73663", "map_id": "CHEBI:46245", "name": "CoQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_76633", "map_id": "CHEBI:17976", "name": "QH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10678180", "map_id": "none", "name": "ETF:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10678190", "map_id": "Q54XM6", "name": "etfdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0278849", "map_id": "DDB_G0278849", "name": "etfdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677420", "map_id": "none", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10677284", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N1", "map_id": "Q869N1", "name": "cytC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275537", "map_id": "DDB_G0275537", "name": "cytC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677282", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10677417", "map_id": "none", "name": "Ubiquinol-cytochrome c reductase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54NW9", "map_id": "Q54NW9", "name": "ucr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284947", "map_id": "DDB_G0284947", "name": "ucr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V76", "map_id": "Q54V76", "name": "UQCRQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280569", "map_id": "DDB_G0280569", "name": "UQCRQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M82", "map_id": "Q54M82", "name": "UQCRB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286171", "map_id": "DDB_G0286171", "name": "UQCRB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W6B5", "map_id": "Q4W6B5", "name": "mppB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288777", "map_id": "DDB_G0288777", "name": "mppB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A84", "map_id": "Q86A84", "name": "mppA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274809", "map_id": "DDB_G0274809", "name": "mppA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D07", "map_id": "Q54D07", "name": "cyc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292594", "map_id": "DDB_G0292594", "name": "cyc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q37311", "map_id": "Q37311", "name": "cytB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294078", "map_id": "DDB_G0294078", "name": "cytB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXP3", "map_id": "Q1ZXP3", "name": "uqcrh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271774", "map_id": "DDB_G0271774", "name": "uqcrh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR8", "map_id": "Q54QR8", "name": "UQCR10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283669", "map_id": "DDB_G0283669", "name": "UQCR10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F93", "map_id": "Q54F93", "name": "mppA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290997", "map_id": "DDB_G0290997", "name": "mppA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709072", "map_id": "none", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_169274", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10709068", "map_id": "Q54F15", "name": "nubpl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0291193", "map_id": "DDB_G0291193", "name": "nubpl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709070", "map_id": "none", "name": "NUBPL:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54F15", "map_id": "Q54F15", "name": "nubpl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714760", "map_id": "none", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10714105", "map_id": "none", "name": "NDUFA9:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q559Z0", "map_id": "Q559Z0", "name": "ndufa9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272266", "map_id": "DDB_G0272266", "name": "ndufa9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711174", "map_id": "none", "name": "NDUFS7:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NI6", "map_id": "Q54NI6", "name": "ndufs7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285239", "map_id": "DDB_G0285239", "name": "ndufs7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714098", "map_id": "none", "name": "NDUFAF7:NDUFS2:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54S83", "map_id": "Q54S83", "name": "midA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282615", "map_id": "DDB_G0282615", "name": "midA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23883", "map_id": "Q23883", "name": "nad7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294030", "map_id": "DDB_G0294030", "name": "nad7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714110", "map_id": "P22237", "name": "nad9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0294032", "map_id": "DDB_G0294032", "name": "nad9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711176", "map_id": "none", "name": "NDUFS8:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86K57", "map_id": "Q86K57", "name": "NDUFS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277231", "map_id": "DDB_G0277231", "name": "NDUFS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714112", "map_id": "none", "name": "IP subcomplex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P22237", "map_id": "P22237", "name": "nad9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678185", "map_id": "none", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10711196", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10711190", "map_id": "Q54F10", "name": "ndufv2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0291173", "map_id": "DDB_G0291173", "name": "ndufv2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711185", "map_id": "Q54I90", "name": "ndufv1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0288875", "map_id": "DDB_G0288875", "name": "ndufv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711194", "map_id": "none", "name": "NDUFV2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54F10", "map_id": "Q54F10", "name": "ndufv2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711192", "map_id": "none", "name": "NDUFV1:4Fe-4S:FMN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54I90", "map_id": "Q54I90", "name": "ndufv1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711180", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10711168", "map_id": "none", "name": "NDUF subunits", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q34312", "map_id": "Q34312", "name": "nad11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294052", "map_id": "DDB_G0294052", "name": "nad11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711178", "map_id": "none", "name": "NDUF:4Fe-4S subunits", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10716369", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6810408", "map_id": "CHEBI:16500", "name": "PI5P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6810412", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10716366", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86D86", "map_id": "Q86D86", "name": "rpkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283615", "map_id": "DDB_G0283615", "name": "rpkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A02", "map_id": "Q86A02", "name": "PIPkinA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275635", "map_id": "DDB_G0275635", "name": "PIPkinA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556H0", "map_id": "Q556H0", "name": "PIP4K2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292190", "map_id": "DDB_G0292190", "name": "PIP4K2C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VR4", "map_id": "Q54VR4", "name": "PIP4K2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GN6", "map_id": "Q55GN6", "name": "PIP4K2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M96", "map_id": "Q54M96", "name": "PIP4K2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL4", "map_id": "Q54DL4", "name": "PIP4K2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714921", "map_id": "none", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10714909", "map_id": "none", "name": "KAT6A:ING5:MEAF6:BRPF1,(2,3)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q869X5", "map_id": "Q869X5", "name": "phospho-p-T369-KAT6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275017", "map_id": "DDB_G0275017", "name": "phospho-p-T369-KAT6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G130", "map_id": "B0G130", "name": "KAT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279699", "map_id": "DDB_G0279699", "name": "KAT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PN9", "map_id": "Q54PN9", "name": "dng1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284411", "map_id": "DDB_G0284411", "name": "dng1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG3", "map_id": "Q54NG3", "name": "MEAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285275", "map_id": "DDB_G0285275", "name": "MEAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714919", "map_id": "none", "name": "p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10680373", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721110", "map_id": "none", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721103", "map_id": "none", "name": "p-S326-PIP4K2B dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10687932", "map_id": "Q55EZ0", "name": "pinA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268618", "map_id": "DDB_G0268618", "name": "pinA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721108", "map_id": "none", "name": "p-S326-PIP4K2B dimers:PIN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55EZ0", "map_id": "Q55EZ0", "name": "pinA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721106", "map_id": "none", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721092", "map_id": "none", "name": "PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10685946", "map_id": "Q54HS0", "name": "phospho-p-S207,T211-MAP2K6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10716021", "map_id": "none", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700208", "map_id": "Q54PN9", "name": "dng1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10716019", "map_id": "none", "name": "ING2:PI5P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10671182", "map_id": "none", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671179", "map_id": "Q86H28", "name": "prodh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0275669", "map_id": "DDB_G0275669", "name": "prodh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722466", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10710922", "map_id": "Q86H28", "name": "prodh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10690088", "map_id": "none", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685244", "map_id": "none", "name": "AQP1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54V53", "map_id": "Q54V53", "name": "wacA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280537", "map_id": "DDB_G0280537", "name": "wacA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U8P7", "map_id": "Q9U8P7", "name": "aqpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267378", "map_id": "DDB_G0267378", "name": "aqpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FQ9", "map_id": "Q54FQ9", "name": "MIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290691", "map_id": "DDB_G0290691", "name": "MIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690056", "map_id": "none", "name": "RHAG transports CO2 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685560", "map_id": "none", "name": "Homologues of RHAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NIV0", "map_id": "Q9NIV0", "name": "rhgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283389", "map_id": "DDB_G0283389", "name": "rhgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I0L6", "map_id": "Q8I0L6", "name": "rhgB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280059", "map_id": "DDB_G0280059", "name": "rhgB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702542", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702540", "map_id": "none", "name": "ARF4:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YV7", "map_id": "Q54YV7", "name": "arrL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278057", "map_id": "DDB_G0278057", "name": "arrL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00909", "map_id": "O00909", "name": "arfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289173", "map_id": "DDB_G0289173", "name": "arfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JJ3", "map_id": "Q54JJ3", "name": "arrH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288015", "map_id": "DDB_G0288015", "name": "arrH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HK2", "map_id": "Q54HK2", "name": "arrF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289435", "map_id": "DDB_G0289435", "name": "arrF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA5", "map_id": "Q1ZXA5", "name": "ARF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292332", "map_id": "DDB_G0292332", "name": "ARF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V41", "map_id": "Q54V41", "name": "arrK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280633", "map_id": "DDB_G0280633", "name": "arrK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29420", "map_id": "CHEBI:58189", "name": "GDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54SH9", "map_id": "Q54SH9", "name": "arrA", "type": 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"gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I24", "map_id": "Q54I24", "name": "arrD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289069", "map_id": "DDB_G0289069", "name": "arrD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y34", "map_id": "Q54Y34", "name": "ARF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AR1", "map_id": "Q55AR1", "name": "arrC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271792", "map_id": "DDB_G0271792", "name": "arrC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VB0", "map_id": "Q54VB0", "name": "arrE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280479", "map_id": "DDB_G0280479", "name": "arrE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702524", "map_id": "none", "name": "ARF4:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10682450", "map_id": "none", "name": "Homologues of GBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q86KG9", "map_id": "Q86KG9", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290771", "map_id": "DDB_G0290771", "name": "GBF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X30", "map_id": "Q54X30", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FL9", "map_id": "Q54FL9", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723639", "map_id": "none", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723634", "map_id": "none", "name": "RHOQ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34146", "map_id": "P34146", "name": "rac1C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282365", "map_id": "DDB_G0282365", "name": "rac1C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPQ9", "map_id": "Q9GPQ9", "name": "racJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292560", "map_id": "DDB_G0292560", "name": "racJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YY4", "map_id": "Q54YY4", "name": "racN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278009", "map_id": "DDB_G0278009", "name": "racN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXJ6", "map_id": "Q1ZXJ6", "name": "racQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278011", "map_id": "DDB_G0278011", "name": "racQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96390", "map_id": "O96390", "name": "racF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269176", "map_id": "DDB_G0269176", "name": "racF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPR7", "map_id": "Q9GPR7", "name": "racH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269240", "map_id": "DDB_G0269240", "name": "racH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPS3", "map_id": "Q9GPS3", "name": "racF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276967", "map_id": "DDB_G0276967", "name": "racF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34150", "map_id": "P34150", "name": "racD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291976", "map_id": "DDB_G0291976", "name": "racD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34148", "map_id": "P34148", "name": "racB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279605", "map_id": "DDB_G0279605", "name": "racB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N82", "map_id": "Q54N82", "name": "RHOBTB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285453", "map_id": "DDB_G0285453", "name": "RHOBTB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34149", "map_id": "P34149", "name": "racC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293526", "map_id": "DDB_G0293526", "name": "racC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34145", "map_id": "P34145", "name": "rac1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268622", "map_id": "DDB_G0268622", "name": "rac1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23862", "map_id": "Q23862", "name": "racE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280975", "map_id": "DDB_G0280975", "name": "racE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723636", "map_id": "none", "name": "RHOQ:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723261", "map_id": "none", "name": "Homologues of ARHGAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ND2", "map_id": "Q54ND2", "name": "ARHGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285391", "map_id": "DDB_G0285391", "name": "ARHGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSN9", "map_id": "Q8SSN9", "name": "gacF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274243", "map_id": "DDB_G0274243", "name": "gacF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DW9", "map_id": "Q55DW9", "name": "gacZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269496", "map_id": "DDB_G0269496", "name": "gacZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TH9", "map_id": "Q54TH9", "name": "gacY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281739", "map_id": "DDB_G0281739", "name": "gacY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XT6", "map_id": "Q54XT6", "name": "gacR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278755", "map_id": "DDB_G0278755", "name": "gacR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J98", "map_id": "Q54J98", "name": "gacX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288205", "map_id": "DDB_G0288205", "name": "gacX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FF4", "map_id": "Q54FF4", "name": "gacL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290891", "map_id": "DDB_G0290891", "name": "gacL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723645", "map_id": "none", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723641", "map_id": "none", "name": "RHOQ effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55D99", "map_id": "Q55D99", "name": "pakA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269166", "map_id": "DDB_G0269166", "name": "pakA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DD4", "map_id": "Q55DD4", "name": "pakD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269696", "map_id": "DDB_G0269696", "name": "pakD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YXU4", "map_id": "Q7YXU4", "name": "cpnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293008", "map_id": "DDB_G0293008", "name": "cpnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K32", "map_id": "Q54K32", "name": "rgaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287585", "map_id": "DDB_G0287585", "name": "rgaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K65", "map_id": "Q54K65", "name": "STOM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290995", "map_id": "DDB_G0290995", "name": "STOM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00899", "map_id": "O00899", "name": "gapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269140", "map_id": "DDB_G0269140", "name": "gapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36411", "map_id": "P36411", "name": "rab7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269236", "map_id": "DDB_G0269236", "name": "rab7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPS0", "map_id": "Q9GPS0", "name": "racG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269178", "map_id": "DDB_G0269178", "name": "racG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA8", "map_id": "Q1ZXA8", "name": "LAMTOR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292160", "map_id": "DDB_G0292160", "name": "LAMTOR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F95", "map_id": "Q54F95", "name": "STOM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I34", "map_id": "Q54I34", "name": "IQGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289033", "map_id": "DDB_G0289033", "name": "IQGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N2", "map_id": "Q869N2", "name": "pakB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276459", "map_id": "DDB_G0276459", "name": "pakB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723643", "map_id": "none", "name": "RHOQ:GTP:RHOQ effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723650", "map_id": "none", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723647", "map_id": "none", "name": "RHOQ GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PK2", "map_id": "Q54PK2", "name": "ARHGEF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291085", "map_id": "DDB_G0291085", "name": "ARHGEF9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F64", "map_id": "Q54F64", "name": "ARHGEF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J11", "map_id": "Q54J11", "name": "gxcI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288383", "map_id": "DDB_G0288383", "name": "gxcI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MM3", "map_id": "Q54MM3", "name": "SPATA13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285859", "map_id": "DDB_G0285859", "name": "SPATA13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B37", "map_id": "Q54B37", "name": "gxcJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293978", "map_id": "DDB_G0293978", "name": "gxcJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KI4", "map_id": "Q54KI4", "name": "eps15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287325", "map_id": "DDB_G0287325", "name": "eps15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXN6", "map_id": "Q1ZXN6", "name": "gxcM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272372", "map_id": "DDB_G0272372", "name": "gxcM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723940", "map_id": "none", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723938", "map_id": "none", "name": "RHOQ:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10705788", "map_id": "none", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705770", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q557E6", "map_id": "Q557E6", "name": "RAD51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273139", "map_id": "DDB_G0273139", "name": "RAD51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ED2", "map_id": "Q54ED2", "name": "exo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291570", "map_id": "DDB_G0291570", "name": "exo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC4", "map_id": "Q54GC4", "name": "RMI2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290275", "map_id": "DDB_G0290275", "name": "RMI2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CS9", "map_id": "Q54CS9", "name": "rad50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292786", "map_id": "DDB_G0292786", "name": "rad50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553E9", "map_id": "Q553E9", "name": "smg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275845", "map_id": "DDB_G0275845", "name": "smg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LI7", "map_id": "Q54LI7", "name": "phospho-p-S990,Ac-K1249-BRIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286621", "map_id": "DDB_G0286621", "name": "phospho-p-S990,Ac-K1249-BRIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM3", "map_id": "Q54DM3", "name": "BLM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292130", "map_id": "DDB_G0292130", "name": "BLM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2T7", "map_id": "Q8T2T7", "name": "top3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275257", "map_id": "DDB_G0275257", "name": "top3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IV6", "map_id": "Q86IV6", "name": "DNA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274777", "map_id": "DDB_G0274777", "name": "DNA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q57", "map_id": "Q54Q57", "name": "RMI1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284153", "map_id": "DDB_G0284153", "name": "RMI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BN2", "map_id": "Q54BN2", "name": "MRE11A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293546", "map_id": "DDB_G0293546", "name": "MRE11A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10705784", "map_id": "none", "name": "BCDX2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54G98", "map_id": "Q54G98", "name": "XRCC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290297", "map_id": "DDB_G0290297", "name": "XRCC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ7", "map_id": "Q54PJ7", "name": "rad51c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284507", "map_id": "DDB_G0284507", "name": "rad51c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF0", "map_id": "Q1ZXF0", "name": "rad51d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285287", "map_id": "DDB_G0285287", "name": "rad51d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10705786", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705715", "map_id": "none", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705710", "map_id": "Q557E6", "name": "RAD51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10705713", "map_id": "Q557E6", "name": "phospho-p-T309-RAD51", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670810", "map_id": "none", "name": "Homologues of p-S317,S345-CHEK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54YF2", "map_id": "Q54YF2", "name": "phospho-snfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277905", "map_id": "DDB_G0277905", "name": "phospho-snfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV2", "map_id": "Q54MV2", "name": "phospho-mrkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285643", "map_id": "DDB_G0285643", "name": "phospho-mrkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10705801", "map_id": "none", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705796", "map_id": "none", "name": "3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30555", "map_id": "CHEBI:16516", "name": "dNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10705798", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674992", "map_id": "none", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674988", "map_id": "Q55E38", "name": "RAD52", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269406", "map_id": "DDB_G0269406", "name": "RAD52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674990", "map_id": "none", "name": "RAD52 heptamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55E38", "map_id": "Q55E38", "name": "RAD52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710990", "map_id": "none", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710986", "map_id": "Q54BR4", "name": "FANCI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293476", "map_id": "DDB_G0293476", "name": "FANCI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710981", "map_id": "Q55F81", "name": "FANCD2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268216", "map_id": "DDB_G0268216", "name": "FANCD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710988", "map_id": "none", "name": "FANCD2:FANCI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BR4", "map_id": "Q54BR4", "name": "FANCI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F81", "map_id": "Q55F81", "name": "FANCD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722017", "map_id": "none", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722004", "map_id": "none", "name": "UBA3:NAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QG9", "map_id": "Q54QG9", "name": "uba3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283891", "map_id": "DDB_G0283891", "name": "uba3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JM3", "map_id": "Q54JM3", "name": "nae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287965", "map_id": "DDB_G0287965", "name": "nae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709503", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278711", "map_id": "DDB_G0278711", "name": "nedd8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722014", "map_id": "none", "name": "NEDD8-UBA3:NAE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XV3", "map_id": "Q54XV3", "name": "nedd8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722037", "map_id": "none", "name": "Transfer of NEDD8 to AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722026", "map_id": "none", "name": "AcM-UBE2M:NEDD8-UBA3:NAE1:NEDD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TI6", "map_id": "Q54TI6", "name": "ube2m", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281725", "map_id": "DDB_G0281725", "name": "ube2m", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722034", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722288", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722257", "map_id": "none", "name": "DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86JM4", "map_id": "Q86JM4", "name": "DCUN1D5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272016", "map_id": "DDB_G0272016", "name": "DCUN1D5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GP1", "map_id": "Q54GP1", "name": "DCUN1D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290025", "map_id": "DDB_G0290025", "name": "DCUN1D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G147", "map_id": "B0G147", "name": "DCUN1D4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284369", "map_id": "DDB_G0284369", "name": "DCUN1D4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722191", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10722245", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MK9", "map_id": "Q54MK9", "name": "DCAF8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285955", "map_id": "DDB_G0285955", "name": "DCAF8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554G3", "map_id": "Q554G3", "name": "commd10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275249", "map_id": "DDB_G0275249", "name": "commd10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550I8", "map_id": "Q550I8", "name": "commd4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277089", "map_id": "DDB_G0277089", "name": "commd4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWL3", "map_id": "Q7KWL3", "name": "wdsof1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276815", "map_id": "DDB_G0276815", "name": "wdsof1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I14", "map_id": "Q86I14", "name": "commd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275055", "map_id": "DDB_G0275055", "name": "commd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MA5", "map_id": "Q54MA5", "name": "commd6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286077", "map_id": "DDB_G0286077", "name": "commd6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DR0", "map_id": "Q54DR0", "name": "commd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292074", "map_id": "DDB_G0292074", "name": "commd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MH6", "map_id": "Q54MH6", "name": "rbbE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285847", "map_id": "DDB_G0285847", "name": "rbbE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CU8", "map_id": "Q54CU8", "name": "commd8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292688", "map_id": "DDB_G0292688", "name": "commd8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DE3", "map_id": "Q55DE3", "name": "DCAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269686", "map_id": "DDB_G0269686", "name": "DCAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K33", "map_id": "Q54K33", "name": "rbx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287629", "map_id": "DDB_G0287629", "name": "rbx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0P5", "map_id": "B0M0P5", "name": "repE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286013", "map_id": "DDB_G0286013", "name": "repE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SD4", "map_id": "Q54SD4", "name": "rbbD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282529", "map_id": "DDB_G0282529", "name": "rbbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E28", "map_id": "Q54E28", "name": "DCAF11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291832", "map_id": "DDB_G0291832", "name": "DCAF11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IY4", "map_id": "Q54IY4", "name": "RFWD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288453", "map_id": "DDB_G0288453", "name": "RFWD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CS2", "map_id": "Q54CS2", "name": "culD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292794", "map_id": "DDB_G0292794", "name": "culD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P14", "map_id": "Q54P14", "name": "commd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284879", "map_id": "DDB_G0284879", "name": "commd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IW8", "map_id": "Q86IW8", "name": "commd5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274791", "map_id": "DDB_G0274791", "name": "commd5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552R1", "map_id": "Q552R1", "name": "wdr68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275925", "map_id": "DDB_G0275925", "name": "wdr68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551N8", "map_id": "Q551N8", "name": "ERCC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276481", "map_id": "DDB_G0276481", "name": "ERCC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KL5", "map_id": "Q54KL5", "name": "wdr5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287273", "map_id": "DDB_G0287273", "name": "wdr5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MP2", "map_id": "Q54MP2", "name": "CCDC22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285813", "map_id": "DDB_G0285813", "name": "CCDC22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QK4", "map_id": "Q54QK4", "name": "commd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283795", "map_id": "DDB_G0283795", "name": "commd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW6", "map_id": "Q54QW6", "name": "RBBP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283565", "map_id": "DDB_G0283565", "name": "RBBP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722259", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709510", "map_id": "none", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709501", "map_id": "none", "name": "UCHL3,SENP8:NEDD8(1-88)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T48", "map_id": "Q54T48", "name": "uch1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282007", "map_id": "DDB_G0282007", "name": "uch1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709507", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10709505", "map_id": "none", "name": "UCHL3,SENP8:NEDD8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722444", "map_id": "none", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709665", "map_id": "Q86KD1", "name": "cand1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274167", "map_id": "DDB_G0274167", "name": "cand1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722440", "map_id": "none", "name": "CRL E3 ubiquitin ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UQ3", "map_id": "Q54UQ3", "name": "FBXW4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280895", "map_id": "DDB_G0280895", "name": "FBXW4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XF7", "map_id": "Q54XF7", "name": "culE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278991", "map_id": "DDB_G0278991", "name": "culE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JC1", "map_id": "Q86JC1", "name": "ANKRD9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272666", "map_id": "DDB_G0272666", "name": "ANKRD9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZJ3", "map_id": "Q9XZJ3", "name": "culB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267384", "map_id": "DDB_G0267384", "name": "culB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LV9", "map_id": "Q54LV9", "name": "BTBD6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286387", "map_id": "DDB_G0286387", "name": "BTBD6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BF8", "map_id": "Q55BF8", "name": "KBTBD8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274267", "map_id": "DDB_G0274267", "name": "KBTBD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AD8", "map_id": "Q86AD8", "name": "DG1106", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271500", "map_id": "DDB_G0271500", "name": "DG1106", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O60999", "map_id": "O60999", "name": "culA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291972", "map_id": "DDB_G0291972", "name": "culA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q05", "map_id": "Q54Q05", "name": "tceb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284201", "map_id": "DDB_G0284201", "name": "tceb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RP0", "map_id": "Q54RP0", "name": "agtA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283005", "map_id": "DDB_G0283005", "name": "agtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C56", "map_id": "Q55C56", "name": "ANKRD9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWS8", "map_id": "Q7KWS8", "name": "BTRC", "type": 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"gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DF3", "map_id": "Q54DF3", "name": "FBXO10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292302", "map_id": "DDB_G0292302", "name": "FBXO10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J11", "map_id": "Q86J11", "name": "KBTBD8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA6", "map_id": "Q54XA6", "name": "KLHL42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279093", "map_id": "DDB_G0279093", "name": "KLHL42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557E4", "map_id": "Q557E4", "name": "fpaB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273251", "map_id": "DDB_G0273251", "name": "fpaB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL2", "map_id": "Q54DL2", "name": "KCTD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292144", "map_id": "DDB_G0292144", "name": "KCTD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52285", "map_id": "P52285", "name": "fpaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269230", "map_id": "DDB_G0269230", "name": "fpaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NZ5", "map_id": "Q54NZ5", "name": "culC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F90", "map_id": "Q54F90", "name": "FBXW7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291003", "map_id": "DDB_G0291003", "name": "FBXW7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X83", "map_id": "Q54X83", "name": "ASB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279139", "map_id": "DDB_G0279139", "name": "ASB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K42", "map_id": "Q86K42", "name": "ASB16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277249", "map_id": "DDB_G0277249", "name": "ASB16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D84", "map_id": "Q54D84", "name": "triA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292436", "map_id": "DDB_G0292436", "name": "triA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722442", "map_id": "none", "name": "CRL E3 ubiquitin ligase:CAND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KD1", "map_id": "Q86KD1", "name": "cand1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722556", "map_id": "none", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722283", "map_id": "none", "name": "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10722553", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10722551", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10709642", "map_id": "none", "name": "COP9 signalosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QX3", "map_id": "Q54QX3", "name": "csn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283587", "map_id": "DDB_G0283587", "name": "csn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PF3", "map_id": "Q54PF3", "name": "csn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284597", "map_id": "DDB_G0284597", "name": "csn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL6", "map_id": "Q54HL6", "name": "csn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289361", "map_id": "DDB_G0289361", "name": "csn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B82", "map_id": "Q54B82", "name": "csn4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293844", "map_id": "DDB_G0293844", "name": "csn4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E53", "map_id": "Q54E53", "name": "csn3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291848", "map_id": "DDB_G0291848", "name": "csn3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75K24", "map_id": "Q75K24", "name": "csn8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275471", "map_id": "DDB_G0275471", "name": "csn8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BD5", "map_id": "Q55BD5", "name": "csn7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271282", "map_id": "DDB_G0271282", "name": "csn7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C92", "map_id": "Q54C92", "name": "csn6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293180", "map_id": "DDB_G0293180", "name": "csn6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722452", "map_id": "none", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722448", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10722243", "map_id": "none", "name": "COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10722446", "map_id": "Q86KD1", "name": "cand1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10722571", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722567", "map_id": "Q55BU7", "name": "ubxd7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270358", "map_id": "DDB_G0270358", "name": "ubxd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722562", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722569", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BU7", "map_id": "Q55BU7", "name": "ubxd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722039", "map_id": "none", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722024", "map_id": "Q54TI6", "name": "ube2m", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10722019", "map_id": "none", "name": "NEDD8-UBA3:NAE1:NEDD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722021", "map_id": "none", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10722450", "map_id": "none", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722219", "map_id": "none", "name": "RBX1:CUL4:DDB1:DCAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722460", "map_id": "none", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722118", "map_id": "none", "name": "COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722458", "map_id": "none", "name": "CRL E3 ubiquitin ligase:COMMDs:CCDC22", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722577", "map_id": "none", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722160", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722178", "map_id": "Q54GP1", "name": "MyrG-DCUN1D3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10722180", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722182", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722162", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722174", "map_id": "none", "name": "NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722185", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722143", "map_id": "none", "name": "DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722286", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722261", "map_id": "Q54TI6", "name": "ube2m", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10722549", "map_id": "none", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722536", "map_id": "none", "name": "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722546", "map_id": "none", "name": "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10718564", "map_id": "none", "name": "COP9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721997", "map_id": "none", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709192", "map_id": "Q54T48", "name": "uch1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10678743", "map_id": "none", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670505", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54C30", "map_id": "Q54C30", "name": "cdc26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293230", "map_id": "DDB_G0293230", "name": "cdc26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE6", "map_id": "Q1ZXE6", "name": "anapc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286233", "map_id": "DDB_G0286233", "name": "anapc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ER5", "map_id": "Q55ER5", "name": "anapc10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268992", "map_id": "DDB_G0268992", "name": "anapc10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B11", "map_id": "Q86B11", "name": "anapc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272775", "map_id": "DDB_G0272775", "name": "anapc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D58", "map_id": "Q54D58", "name": "anapc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292470", "map_id": "DDB_G0292470", "name": "anapc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551S9", "map_id": "Q551S9", "name": "anapc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276377", "map_id": "DDB_G0276377", "name": "anapc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NC6", "map_id": "Q54NC6", "name": "anapc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285349", "map_id": "DDB_G0285349", "name": "anapc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XS6", "map_id": "Q54XS6", "name": "ube2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278775", "map_id": "DDB_G0278775", "name": "ube2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NI1", "map_id": "Q54NI1", "name": "anapc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285223", "map_id": "DDB_G0285223", "name": "anapc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L48", "map_id": "Q54L48", "name": "anapc11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286909", "map_id": "DDB_G0286909", "name": "anapc11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I43", "map_id": "Q54I43", "name": "ube2s", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289021", "map_id": "DDB_G0289021", "name": "ube2s", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J83", "map_id": "Q54J83", "name": "anapc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288223", "map_id": "DDB_G0288223", "name": "anapc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VV5", "map_id": "Q54VV5", "name": "anapc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280113", "map_id": "DDB_G0280113", "name": "anapc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670510", "map_id": "Q54KM3", "name": "cdh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287259", "map_id": "DDB_G0287259", "name": "cdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670512", "map_id": "none", "name": "phospho-APC/C:Cdh1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KM3", "map_id": "Q54KM3", "name": "cdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678860", "map_id": "none", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678797", "map_id": "none", "name": "CDC20:p-APC/C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MZ3", "map_id": "Q54MZ3", "name": "cdc20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285601", "map_id": "DDB_G0285601", "name": "cdc20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676841", "map_id": "Q54MZ3", "name": "cdc20", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680376", "map_id": "none", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10680349", "map_id": "P34102", "name": "pkgC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286125", "map_id": "DDB_G0286125", "name": "phospho-pkgC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680353", "map_id": "P34102", "name": "phospho-pkgC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10699967", "map_id": "none", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699958", "map_id": "none", "name": "EHMT1:EHMT2:Cdh1:p-APC/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10669917", "map_id": "none", "name": "Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10699964", "map_id": "none", "name": "Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10699948", "map_id": "none", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678749", "map_id": "none", "name": "Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10678751", "map_id": "none", "name": "Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10699950", "map_id": "none", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678747", "map_id": "none", "name": "Cdh1:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10669684", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10691859", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10691856", "map_id": "none", "name": "CEPT1/EPT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54XM0", "map_id": "Q54XM0", "name": "captB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278947", "map_id": "DDB_G0278947", "name": "captB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AQ3", "map_id": "Q55AQ3", "name": "captA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271794", "map_id": "DDB_G0271794", "name": "captA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29418", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q8T2Q6", "map_id": "Q8T2Q6", "name": "captD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275235", "map_id": "DDB_G0275235", "name": "captD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692020", "map_id": "none", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10692017", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10692009", "map_id": "none", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_110614", "map_id": "CHEBI:37563", "name": "CTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692006", "map_id": "none", "name": "PCYT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BZ4", "map_id": "Q55BZ4", "name": "pctA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270298", "map_id": "DDB_G0270298", "name": "pctA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692047", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692044", "map_id": "none", "name": "CHK/ETNK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q554D8", "map_id": "Q554D8", "name": "etnkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275265", "map_id": "DDB_G0275265", "name": "etnkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869T9", "map_id": "Q869T9", "name": "etnkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274955", "map_id": "DDB_G0274955", "name": "etnkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676812", "map_id": "none", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500604", "map_id": "CHEBI:50157", "name": "5HIALD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676809", "map_id": "none", "name": "MAOA:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54RP5", "map_id": "Q54RP5", "name": "MAOA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282999", "map_id": "DDB_G0282999", "name": "MAOA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683049", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671999", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54FY3", "map_id": "Q54FY3", "name": "hydA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290479", "map_id": "DDB_G0290479", "name": "hydA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676257", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676252", "map_id": "none", "name": "activated PDE1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23917", "map_id": "Q23917", "name": "phospho-regA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284331", "map_id": "DDB_G0284331", "name": "phospho-regA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676232", "map_id": "none", "name": "CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10676146", "map_id": "none", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10676143", "map_id": "none", "name": "Activated PLC beta 1/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34043", "map_id": "P34043", "name": "gpaE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286185", "map_id": "DDB_G0286185", "name": "gpaE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EP5", "map_id": "Q55EP5", "name": "gpaJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268802", "map_id": "DDB_G0268802", "name": "gpaJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34042", "map_id": "P34042", "name": "gpaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285425", "map_id": "DDB_G0285425", "name": "gpaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34044", "map_id": "P34044", "name": "gpaF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283151", "map_id": "DDB_G0283151", "name": "gpaF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02158", "map_id": "Q02158", "name": "plc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292736", "map_id": "DDB_G0292736", "name": "plc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676255", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10676273", "map_id": "none", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676101", "map_id": "Q02158", "name": "plc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676271", "map_id": "none", "name": "G-protein alpha:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10676198", "map_id": "none", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676189", "map_id": "none", "name": "p-T200-CAMK4:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54W86", "map_id": "Q54W86", "name": "phospho-p-T200-CAMK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279831", "map_id": "DDB_G0279831", "name": "phospho-p-T200-CAMK4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676195", "map_id": "none", "name": "p-S12.S13,T200-CAMK4:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676157", "map_id": "none", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426925", "map_id": "CHEBI:16110", "name": "PC", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10676153", "map_id": "Q54CM2", "name": "phospho-p-S505,S727-PLA2G4A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0292858", "map_id": "DDB_G0292858", "name": "phospho-p-S505,S727-PLA2G4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676155", "map_id": "none", "name": "Active PLA2:phosphatidylcholine", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54CM2", "map_id": "Q54CM2", "name": "phospho-p-S505,S727-PLA2G4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676160", "map_id": "none", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_428981", "map_id": "CHEBI:17504", "name": "LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10676234", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10676221", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03100", "map_id": "Q03100", "name": "acaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281545", "map_id": "DDB_G0281545", "name": "acaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685523", "map_id": "none", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685515", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55CW1", "map_id": "Q55CW1", "name": "phospho-samkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270680", "map_id": "DDB_G0270680", "name": "phospho-samkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685520", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10671131", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671114", "map_id": "none", "name": "GOT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55F21", "map_id": "Q55F21", "name": "aatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268664", "map_id": "DDB_G0268664", "name": "aatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682718", "map_id": "none", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682713", "map_id": "Q54RB9", "name": "mcfO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0283329", "map_id": "DDB_G0283329", "name": "mcfO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671817", "map_id": "none", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670887", "map_id": "none", "name": "ALDOB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86A67", "map_id": "Q86A67", "name": "fba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274375", "map_id": "DDB_G0274375", "name": "fba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671014", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670947", "map_id": "none", "name": "GAPDH tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94469", "map_id": "Q94469", "name": "gpdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275153", "map_id": "DDB_G0275153", "name": "gpdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682769", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113573", "map_id": "CHEBI:37565", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_372364", "map_id": "CHEBI:58702", "name": "PEP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113525", "map_id": "CHEBI:58189", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10682766", "map_id": "Q869Z4", "name": "pck2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0271904", "map_id": "DDB_G0271904", "name": "pck2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682774", "map_id": "none", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113544", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113548", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682771", "map_id": "Q54PY7", "name": "ucpC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0284225", "map_id": "DDB_G0284225", "name": "ucpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670994", "map_id": "none", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670989", "map_id": "none", "name": "GPI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5V9E9", "map_id": "Q5V9E9", "name": "gpi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283673", "map_id": "DDB_G0283673", "name": "gpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671814", "map_id": "none", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30485", "map_id": "CHEBI:58289", "name": "2PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671811", "map_id": "none", "name": "PGAM dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NE6", "map_id": "Q54NE6", "name": "gpmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285311", "map_id": "DDB_G0285311", "name": "gpmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671030", "map_id": "none", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671027", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GPM4", "map_id": "Q9GPM4", "name": "pgkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287595", "map_id": "DDB_G0287595", "name": "pgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680112", "map_id": "none", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680109", "map_id": "none", "name": "SLC25A11 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54PY7", "map_id": "Q54PY7", "name": "ucpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682918", "map_id": "none", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671010", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671007", "map_id": "none", "name": "FBP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6RYT0", "map_id": "Q6RYT0", "name": "fbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270836", "map_id": "DDB_G0270836", "name": "fbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670833", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29492", "map_id": "CHEBI:58702", "name": "PEP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670830", "map_id": "Q869Z4", "name": "pck2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680122", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680119", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GE6", "map_id": "Q54GE6", "name": "mdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290207", "map_id": "DDB_G0290207", "name": "mdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671057", "map_id": "none", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671054", "map_id": "none", "name": "enolase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RK5", "map_id": "Q54RK5", "name": "enoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283137", "map_id": "DDB_G0283137", "name": "enoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F83", "map_id": "Q55F83", "name": "enoB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268214", "map_id": "DDB_G0268214", "name": "enoB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671012", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670957", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869R8", "map_id": "Q869R8", "name": "tpiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274471", "map_id": "DDB_G0274471", "name": "tpiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698893", "map_id": "none", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698875", "map_id": "none", "name": "Homologues of p-S407,Y641-STAT6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698877", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10698891", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698889", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698905", "map_id": "none", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698903", "map_id": "none", "name": "Homologues of p-S407-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10690190", "map_id": "none", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29804", "map_id": "CHEBI:29103", "name": "K+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10690187", "map_id": "none", "name": "TREK homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8T268", "map_id": "Q8T268", "name": "KCNK15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277255", "map_id": "DDB_G0277255", "name": "KCNK15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K40", "map_id": "Q86K40", "name": "KCNK15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691628", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691625", "map_id": "none", "name": "LPCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54XX2", "map_id": "Q54XX2", "name": "MBOAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278541", "map_id": "DDB_G0278541", "name": "MBOAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691786", "map_id": "none", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691729", "map_id": "none", "name": "PLA2(9)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691783", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691780", "map_id": "none", "name": "PLA2(5)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PS7", "map_id": "Q54PS7", "name": "plbD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284449", "map_id": "DDB_G0284449", "name": "plbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691768", "map_id": "none", "name": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691637", "map_id": "Q54CM2", "name": "PLA2G4C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10691760", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691757", "map_id": "none", "name": "PLA2(6)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54QX6", "map_id": "Q54QX6", "name": "PNPLA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283553", "map_id": "DDB_G0283553", "name": "PNPLA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QX5", "map_id": "Q54QX5", "name": "PNPLA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691643", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10720446", "map_id": "none", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8874447", "map_id": "none", "name": "PMCHO, PMETAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:17810", "map_id": "CHEBI:17810", "name": "CHEBI:17810", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17476", "map_id": "CHEBI:17476", "name": "CHEBI:17476", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8874450", "map_id": "none", "name": "GPCHO, GPETAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:36314", "map_id": "CHEBI:36314", "name": "CHEBI:36314", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36313", "map_id": "CHEBI:36313", "name": "CHEBI:36313", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10720443", "map_id": "Q86H31", "name": "tmem86", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0275665", "map_id": "DDB_G0275665", "name": "tmem86", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676046", "map_id": "none", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676042", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55D17", "map_id": "Q55D17", "name": "ncbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269814", "map_id": "DDB_G0269814", "name": "ncbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RX0", "map_id": "Q54RX0", "name": "snrpG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282863", "map_id": "DDB_G0282863", "name": "snrpG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KR9", "map_id": "Q54KR9", "name": "ncbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287197", "map_id": "DDB_G0287197", "name": "ncbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G054", "map_id": "C7G054", "name": "snrpE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0302414", "map_id": "DDB_G0302414", "name": "snrpE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A45", "map_id": "Q55A45", "name": "snrpb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272320", "map_id": "DDB_G0272320", "name": "snrpb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XP2", "map_id": "Q54XP2", "name": "snrpf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278821", "map_id": "DDB_G0278821", "name": "snrpf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F84", "map_id": "Q54F84", "name": "LSM10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291015", "map_id": "DDB_G0291015", "name": "LSM10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L45", "map_id": "Q86L45", "name": "snrpD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273003", "map_id": "DDB_G0273003", "name": "snrpD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676044", "map_id": "none", "name": "Mature intronless transcript derived Histone pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675681", "map_id": "none", "name": "U7 snRNP:ZNF473", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676048", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675648", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10725757", "map_id": "none", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10725753", "map_id": "Q55EC4", "name": "SHQ1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269304", "map_id": "DDB_G0269304", "name": "SHQ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677256", "map_id": "Q54T81", "name": "nola4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281933", "map_id": "DDB_G0281933", "name": "nola4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725755", "map_id": "none", "name": "DKC1:SHQ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54T81", "map_id": "Q54T81", "name": "nola4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EC4", "map_id": "Q55EC4", "name": "SHQ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697242", "map_id": "none", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10697226", "map_id": "none", "name": "p-T210-PLK1:Phosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PK4", "map_id": "Q54PK4", "name": "smc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284499", "map_id": "DDB_G0284499", "name": "smc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HV9", "map_id": "Q54HV9", "name": "H2Av2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289193", "map_id": "DDB_G0289193", "name": "H2Av2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LA5", "map_id": "Q54LA5", "name": "H2AZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286747", "map_id": "DDB_G0286747", "name": "H2AZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WG6", "map_id": "Q54WG6", "name": "H2AX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279667", "map_id": "DDB_G0279667", "name": "H2AX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP8", "map_id": "Q54LP8", "name": "H2Bv3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286509", "map_id": "DDB_G0286509", "name": "H2Bv3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HW2", "map_id": "Q54HW2", "name": "H2Av1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289187", "map_id": "DDB_G0289187", "name": "H2Av1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HV7", "map_id": "Q54HV7", "name": "H2Av3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289197", "map_id": "DDB_G0289197", "name": "H2Av3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWR7", "map_id": "Q7KWR7", "name": "H2Bv2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276273", "map_id": "DDB_G0276273", "name": "H2Bv2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ID6", "map_id": "Q54ID6", "name": "phospho-p-S-NCAPG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288819", "map_id": "DDB_G0288819", "name": "phospho-p-S-NCAPG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HN7", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274503", "map_id": "DDB_G0274503", "name": "phospho-PLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NW2", "map_id": "Q76NW2", "name": "H4b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276863", "map_id": "DDB_G0276863", "name": "H4b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LV0", "map_id": "Q54LV0", "name": "smc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286403", "map_id": "DDB_G0286403", "name": "smc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DZ9", "map_id": "Q54DZ9", "name": "phospho-p-S-NCAPH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291894", "map_id": "DDB_G0291894", "name": "phospho-p-S-NCAPH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XY3", "map_id": "Q54XY3", "name": "phospho-p-T1415,S1419-NCAPD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278701", "map_id": "DDB_G0278701", "name": "phospho-p-T1415,S1419-NCAPD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BC2", "map_id": "Q54BC2", "name": "H2Bv1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293758", "map_id": "DDB_G0293758", "name": "H2Bv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697239", "map_id": "none", "name": "Hyperphosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10696648", "map_id": "none", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10696641", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3:H4K20me1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10696645", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29478", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10696618", "map_id": "none", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696614", "map_id": "none", "name": "Condensin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670680", "map_id": "Q54FX2", "name": "rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10696616", "map_id": "none", "name": "Condensin II:RB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697218", "map_id": "none", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696635", "map_id": "none", "name": "Nucleosome with H3K4me2/3:H4K20me1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10697216", "map_id": "none", "name": "Condensin II:Nucleosome with H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697246", "map_id": "none", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676882", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10697244", "map_id": "none", "name": "Phosphorylated Condensin II:Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10688018", "map_id": "none", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682593", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682591", "map_id": "none", "name": "RAP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10684031", "map_id": "none", "name": "Rap1 cAMP-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682708", "map_id": "none", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682705", "map_id": "none", "name": "CalDAG-GEFs:DAG:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_6797635", "map_id": "CHEBI:17815", "name": "1,2-DAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10695705", "map_id": "none", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046060", "map_id": "CHEBI:63544", "name": "DTA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_162743", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113519", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046048", "map_id": "CHEBI:63548", "name": "TTA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10686757", "map_id": "none", "name": "Homologues of ELOVL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10695686", "map_id": "none", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046053", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10695683", "map_id": "none", "name": "ELOVL5/ELOVL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10695701", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10683479", "map_id": "Q8T8P3", "name": "abcD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0293194", "map_id": "DDB_G0293194", "name": "abcD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695703", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10695707", "map_id": "none", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046044", "map_id": "CHEBI:17351", "name": "LINA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046064", "map_id": "CHEBI:456215", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046049", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046063", "map_id": "CHEBI:15530", "name": "LA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10695688", "map_id": "none", "name": "ACSL1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10695771", "map_id": "none", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10693370", "map_id": "Q54DW5", "name": "NAGLU(59-743)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0291998", "map_id": "DDB_G0291998", "name": "NAGLU(59-743)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693345", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090040", "map_id": "CHEBI:63806", "name": "Heparan sulfate chain(3)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10693342", "map_id": "none", "name": "HGSNAT oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54LX9", "map_id": "Q54LX9", "name": "HGSNAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286315", "map_id": "DDB_G0286315", "name": "HGSNAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693855", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10693824", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q55E77", "map_id": "Q55E77", "name": "HS(6)-AGRN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_205687", "map_id": "CHEBI:58223", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10693831", "map_id": "none", "name": "xylosyl-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10693852", "map_id": "none", "name": "XYLT1, XYLT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55F91", "map_id": "Q55F91", "name": "XYLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269900", "map_id": "DDB_G0269900", "name": "XYLT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DR5", "map_id": "Q55DR5", "name": "XYLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CU3", "map_id": "Q55CU3", "name": "XYLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693373", "map_id": "none", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090080", "map_id": "CHEBI:63808", "name": "Heparan sulfate chain(5)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10695363", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10695342", "map_id": "none", "name": "Heparan(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10695349", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10695354", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0267630", "map_id": "DDB_G0267630", "name": "kil1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695757", "map_id": "none", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10695389", "map_id": "none", "name": "HS(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10695396", "map_id": "none", "name": "HS(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10695744", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10695773", "map_id": "none", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090075", "map_id": "CHEBI:63503", "name": "linker chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090063", "map_id": "CHEBI:15936", "name": "D-xylose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605637", "map_id": "CHEBI:28061", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10692355", "map_id": "Q54GE1", "name": "glb1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0290217", "map_id": "DDB_G0290217", "name": "glb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693365", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090033", "map_id": "CHEBI:63666", "name": "Heparan sulfate chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090072", "map_id": "CHEBI:63805", "name": "Heparan sulfate chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678617", "map_id": "CHEBI:28481", "name": "aldehydo-L-iduronic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10693362", "map_id": "Q54J53", "name": "IDUA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0288289", "map_id": "DDB_G0288289", "name": "IDUA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695445", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10695411", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10695443", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10695373", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10695370", "map_id": "none", "name": "Heparan(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_2022890", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10695775", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090045", "map_id": "CHEBI:63811", "name": "Heparan chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10695742", "map_id": "none", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10695737", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10695375", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693351", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10692697", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10695769", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090055", "map_id": "CHEBI:63809", "name": "Heparan sulfate chain(6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090070", "map_id": "CHEBI:63810", "name": "Heparan sulfate chain(7)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10686016", "map_id": "none", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670153", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678140", "map_id": "none", "name": "K63polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686011", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10716925", "map_id": "none", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_6814303", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10684974", "map_id": "Q54CM2", "name": "PLA2G4A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10716046", "map_id": "none", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715737", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q558I0", "map_id": "Q558I0", "name": "rabF1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272905", "map_id": "DDB_G0272905", "name": "rabF1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWT0", "map_id": "Q7KWT0", "name": "rabW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276295", "map_id": "DDB_G0276295", "name": "rabW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SV1", "map_id": "Q54SV1", "name": "rabY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282203", "map_id": "DDB_G0282203", "name": "rabY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NU2", "map_id": "Q54NU2", "name": "rab1D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284985", "map_id": "DDB_G0284985", "name": "rab1D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34140", "map_id": "P34140", "name": "rab1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277867", "map_id": "DDB_G0277867", "name": "rab1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DF4", "map_id": "Q54DF4", "name": "rsmM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292300", "map_id": "DDB_G0292300", "name": "rsmM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34139", "map_id": "P34139", "name": "rab1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283757", "map_id": "DDB_G0283757", "name": "rab1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552K3", "map_id": "Q552K3", "name": "rab1E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275969", "map_id": "DDB_G0275969", "name": "rab1E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EW9", "map_id": "Q54EW9", "name": "rabU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291293", "map_id": "DDB_G0291293", "name": "rabU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34141", "map_id": "P34141", "name": "rabA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291233", "map_id": "DDB_G0291233", "name": "rabA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715128", "map_id": "none", "name": "Homologues of GBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716031", "map_id": "none", "name": "RAB1:GTP:GBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716035", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715194", "map_id": "none", "name": "ARF:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716033", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716071", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716056", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54TP9", "map_id": "Q54TP9", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292148", "map_id": "DDB_G0292148", "name": "ARFGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YD8", "map_id": "Q54YD8", "name": "copb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278285", "map_id": "DDB_G0278285", "name": "copb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F7", "map_id": "Q769F7", "name": "empC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278969", "map_id": "DDB_G0278969", "name": "empC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F9", "map_id": "Q769F9", "name": "empA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288053", "map_id": "DDB_G0288053", "name": "empA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FU2", "map_id": "Q55FU2", "name": "cope", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267950", "map_id": "DDB_G0267950", "name": "cope", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FR9", "map_id": "Q55FR9", "name": "copa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267982", "map_id": "DDB_G0267982", "name": "copa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F6", "map_id": "Q769F6", "name": "empD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277923", "map_id": "DDB_G0277923", "name": "empD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556J9", "map_id": "Q556J9", "name": "surf1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272889", "map_id": "DDB_G0272889", "name": "surf1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EZ6", "map_id": "Q55EZ6", "name": "copd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268702", "map_id": "DDB_G0268702", "name": "copd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CA7", "map_id": "Q54CA7", "name": "copZb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293086", "map_id": "DDB_G0293086", "name": "copZb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HD4", "map_id": "Q54HD4", "name": "copZa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289523", "map_id": "DDB_G0289523", "name": "copZa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR0", "map_id": "Q55CR0", "name": "SEC22B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269942", "map_id": "DDB_G0269942", "name": "SEC22B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BN0", "map_id": "Q54BN0", "name": "empB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293540", "map_id": "DDB_G0293540", "name": "empB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DK9", "map_id": "Q54DK9", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL0", "map_id": "Q54HL0", "name": "copG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289371", "map_id": "DDB_G0289371", "name": "copG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JE5", "map_id": "Q86JE5", "name": "kdelr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272124", "map_id": "DDB_G0272124", "name": "kdelr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23924", "map_id": "Q23924", "name": "copb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284735", "map_id": "DDB_G0284735", "name": "copb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715276", "map_id": "none", "name": "ARFGAP1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716068", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10717044", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10717040", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54UJ4", "map_id": "Q54UJ4", "name": "RAB3GAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281043", "map_id": "DDB_G0281043", "name": "RAB3GAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM6", "map_id": "Q54DM6", "name": "RAB3GAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292124", "map_id": "DDB_G0292124", "name": "RAB3GAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10717028", "map_id": "none", "name": "RAB18:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GY8", "map_id": "Q54GY8", "name": "rab18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289827", "map_id": "DDB_G0289827", "name": "rab18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10717042", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10716044", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716037", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716093", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10716090", "map_id": "none", "name": "SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55GJ4", "map_id": "Q55GJ4", "name": "BNIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267646", "map_id": "DDB_G0267646", "name": "BNIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LH0", "map_id": "Q54LH0", "name": "USE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286811", "map_id": "DDB_G0286811", "name": "USE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JI3", "map_id": "Q75JI3", "name": "nsfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276153", "map_id": "DDB_G0276153", "name": "nsfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9R7", "map_id": "Q9U9R7", "name": "snpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269186", "map_id": "DDB_G0269186", "name": "snpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TZ2", "map_id": "Q54TZ2", "name": "STX18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281429", "map_id": "DDB_G0281429", "name": "STX18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NP6", "map_id": "Q54NP6", "name": "snpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285111", "map_id": "DDB_G0285111", "name": "snpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716076", "map_id": "Q55GJ4", "name": "BNIP1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10716081", "map_id": "Q54TZ2", "name": "STX18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10681096", "map_id": "Q55CR0", "name": "SEC22B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10710119", "map_id": "none", "name": "SNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716086", "map_id": "Q54LH0", "name": "USE1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10710110", "map_id": "none", "name": "NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10716214", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10716212", "map_id": "none", "name": "SEC22B:STX18:USE1L:BNIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10716058", "map_id": "none", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715775", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716054", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716039", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716048", "map_id": "Q55CR0", "name": "SEC22B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10716041", "map_id": "none", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715256", "map_id": "none", "name": "coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10716957", "map_id": "none", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716954", "map_id": "Q54IG1", "name": "AGPAT3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0288863", "map_id": "DDB_G0288863", "name": "AGPAT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717053", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10717050", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10716216", "map_id": "none", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10716210", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55CJ0", "map_id": "Q55CJ0", "name": "RINT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270040", "map_id": "DDB_G0270040", "name": "RINT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YZ1", "map_id": "Q54YZ1", "name": "NBAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277997", "map_id": "DDB_G0277997", "name": "NBAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA1", "map_id": "Q55CA1", "name": "ZW10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270150", "map_id": "DDB_G0270150", "name": "ZW10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716168", "map_id": "none", "name": "p24 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10716208", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10710015", "map_id": "none", "name": "RAB1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10682380", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682377", "map_id": "Q54UF3", "name": "odc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281109", "map_id": "DDB_G0281109", "name": "odc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684029", "map_id": "none", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_10684027", "map_id": "none", "name": "L1:AP-2 Clathrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "Q86KI1", "map_id": "Q86KI1", "name": "ap2a1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273439", "map_id": "DDB_G0273439", "name": "ap2a1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25870", "map_id": "P25870", "name": "chcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277221", "map_id": "DDB_G0277221", "name": "chcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MN58", "map_id": "Q8MN58", "name": "clc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277403", "map_id": "DDB_G0277403", "name": "clc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54672", "map_id": "P54672", "name": "apm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277139", "map_id": "DDB_G0277139", "name": "apm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X82", "map_id": "Q54X82", "name": "ap1b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279141", "map_id": "DDB_G0279141", "name": "ap1b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H39", "map_id": "Q54H39", "name": "ap2s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289721", "map_id": "DDB_G0289721", "name": "ap2s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709972", "map_id": "none", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10709957", "map_id": "Q54JV8", "name": "gcvH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0287773", "map_id": "DDB_G0287773", "name": "gcvH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10709961", "map_id": "none", "name": "GCSH:SAMDLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:14949", "map_id": "CHEBI:14949", "name": "CHEBI:14949", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JV8", "map_id": "Q54JV8", "name": "gcvH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709969", "map_id": "none", "name": "PXLP-K754-GLDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KM7", "map_id": "Q54KM7", "name": "gcvP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287255", "map_id": "DDB_G0287255", "name": "gcvP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709982", "map_id": "none", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10709974", "map_id": "none", "name": "GCSH:DHLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:50746", "map_id": "CHEBI:50746", "name": "CHEBI:50746", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693978", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10709979", "map_id": "Q54DD3", "name": "gcvT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0292326", "map_id": "DDB_G0292326", "name": "gcvT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709987", "map_id": "none", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10709984", "map_id": "none", "name": "DLD dimer:2xFAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54EW8", "map_id": "Q54EW8", "name": "lpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291648", "map_id": "DDB_G0291648", "name": "lpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684177", "map_id": "none", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684174", "map_id": "none", "name": "NOS1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684192", "map_id": "none", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30991", "map_id": "CHEBI:16356", "name": "cGMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684189", "map_id": "none", "name": "cGMP phosphodiesterases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0G0Y8", "map_id": "B0G0Y8", "name": "pde3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268634", "map_id": "DDB_G0268634", "name": "pde3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716937", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10697515", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290279", "map_id": "DDB_G0290279", "name": "dgat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683793", "map_id": "none", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683788", "map_id": "Q54I12", "name": "FAR1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0289081", "map_id": "DDB_G0289081", "name": "FAR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716935", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10710365", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10710362", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10683791", "map_id": "none", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10681884", "map_id": "none", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209793", "map_id": "CHEBI:17697", "name": "Ac5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71284", "map_id": "CHEBI:59789", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71285", "map_id": "CHEBI:57856", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209934", "map_id": "CHEBI:16796", "name": "MLT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681881", "map_id": "Q8T638", "name": "dmtA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0289329", "map_id": "DDB_G0289329", "name": "dmtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681900", "map_id": "none", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_71112", "map_id": "CHEBI:15374", "name": "4aOH-BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209911", "map_id": "CHEBI:17780", "name": "5HTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681897", "map_id": "none", "name": "TPH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XS1", "map_id": "Q54XS1", "name": "pah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278781", "map_id": "DDB_G0278781", "name": "pah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703615", "map_id": "none", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10703600", "map_id": "none", "name": "MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q55BY0", "map_id": "Q55BY0", "name": "U81000", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269162", "map_id": "DDB_G0269162", "name": "U81000", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DY3", "map_id": "Q54DY3", "name": "LAMTOR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291948", "map_id": "DDB_G0291948", "name": "LAMTOR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BR7", "map_id": "Q55BR7", "name": "raptor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270398", "map_id": "DDB_G0270398", "name": "raptor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW5", "map_id": "Q54QW5", "name": "LAMTOR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283567", "map_id": "DDB_G0283567", "name": "LAMTOR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J54", "map_id": "Q54J54", "name": "ATG101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288287", "map_id": "DDB_G0288287", "name": "ATG101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R95", "map_id": "Q54R95", "name": "ULK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283337", "map_id": "DDB_G0283337", "name": "ULK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86C65", "map_id": "Q86C65", "name": "tor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281569", "map_id": "DDB_G0281569", "name": "tor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J23", "map_id": "Q86J23", "name": "LAMTOR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274833", "map_id": "DDB_G0274833", "name": "LAMTOR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86CS2", "map_id": "Q86CS2", "name": "atg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292390", "map_id": "DDB_G0292390", "name": "atg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D08", "map_id": "Q54D08", "name": "lst8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292592", "map_id": "DDB_G0292592", "name": "lst8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550Q4", "map_id": "Q550Q4", "name": "rheb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277041", "map_id": "DDB_G0277041", "name": "rheb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK6", "map_id": "Q54PK6", "name": "RRAGD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284495", "map_id": "DDB_G0284495", "name": "RRAGD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IK1", "map_id": "Q54IK1", "name": "ragA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288701", "map_id": "DDB_G0288701", "name": "ragA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F59", "map_id": "Q54F59", "name": "mapbpip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291091", "map_id": "DDB_G0291091", "name": "mapbpip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703612", "map_id": "none", "name": "MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10725704", "map_id": "none", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10704759", "map_id": "none", "name": "Homologues of MAP1LC3B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54G11", "map_id": "Q54G11", "name": "MAP1LC3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290491", "map_id": "DDB_G0290491", "name": "MAP1LC3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86CR8", "map_id": "Q86CR8", "name": "atg8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286191", "map_id": "DDB_G0286191", "name": "atg8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725700", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54Q21", "map_id": "Q54Q21", "name": "Q54Q21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284133", "map_id": "DDB_G0284133", "name": "Q54Q21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MD1", "map_id": "Q54MD1", "name": "phospho-pex5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286033", "map_id": "DDB_G0286033", "name": "phospho-pex5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CE3", "map_id": "Q55CE3", "name": "SQSTM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270098", "map_id": "DDB_G0270098", "name": "SQSTM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725702", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10704870", "map_id": "none", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704868", "map_id": "none", "name": "BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54676", "map_id": "P54676", "name": "pikE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289601", "map_id": "DDB_G0289601", "name": "pikE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S77", "map_id": "Q54S77", "name": "vps15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282627", "map_id": "DDB_G0282627", "name": "vps15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JI9", "map_id": "Q54JI9", "name": "phospho-atg6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288021", "map_id": "DDB_G0288021", "name": "phospho-atg6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704836", "map_id": "none", "name": "Beclin-1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10724968", "map_id": "none", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724940", "map_id": "none", "name": "Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86I15", "map_id": "Q86I15", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291011", "map_id": "DDB_G0291011", "name": "RNF144B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM8", "map_id": "Q54DM8", "name": "cnrK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292120", "map_id": "DDB_G0292120", "name": "cnrK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X77", "map_id": "Q54X77", "name": "cenB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279151", "map_id": "DDB_G0279151", "name": "cenB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R25", "map_id": "Q54R25", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F86", "map_id": "Q54F86", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IY3", "map_id": "Q54IY3", "name": "cenA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288427", "map_id": "DDB_G0288427", "name": "cenA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZG5", "map_id": "Q54ZG5", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QC7", "map_id": "Q54QC7", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724966", "map_id": "none", "name": "Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722608", "map_id": "none", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722600", "map_id": "none", "name": "LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721824", "map_id": "Q75K07", "name": "phospho-p-S17-FUNDC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0277699", "map_id": "DDB_G0277699", "name": "phospho-p-S17-FUNDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722602", "map_id": "none", "name": "p-S17-FUNDC1:LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q75K07", "map_id": "Q75K07", "name": "phospho-p-S17-FUNDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704860", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10704857", "map_id": "none", "name": "MTMR3,MTMR14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EE1", "map_id": "Q55EE1", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293258", "map_id": "DDB_G0293258", "name": "MTMR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E04", "map_id": "Q55E04", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PT8", "map_id": "Q54PT8", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H00", "map_id": "Q54H00", "name": "MTMR14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289807", "map_id": "DDB_G0289807", "name": "MTMR14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GQ1", "map_id": "Q54GQ1", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BL7", "map_id": "Q55BL7", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YC2", "map_id": "Q54YC2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD2", "map_id": "Q1ZXD2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TD5", "map_id": "Q54TD5", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C52", "map_id": "Q54C52", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AZ2", "map_id": "Q55AZ2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E58", "map_id": "Q55E58", "name": "pats1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269250", "map_id": "DDB_G0269250", "name": "pats1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PL3", "map_id": "Q54PL3", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721818", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10703459", "map_id": "none", "name": "Homologues of ULK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721816", "map_id": "none", "name": "Homologues of ULK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10722606", "map_id": "none", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10701260", "map_id": "none", "name": "ATG5:ATG12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q86CR6", "map_id": "Q86CR6", "name": "atg12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282929", "map_id": "DDB_G0282929", "name": "atg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT9", "map_id": "Q54GT9", "name": "atg5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289881", "map_id": "DDB_G0289881", "name": "atg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722604", "map_id": "none", "name": "p-S17-FUNDC1:LC3:ATG5:ATG12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721827", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10721805", "map_id": "Q75K07", "name": "FUNDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10703635", "map_id": "none", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677526", "map_id": "none", "name": "Active mTORC1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10683113", "map_id": "none", "name": "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10724956", "map_id": "none", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724954", "map_id": "none", "name": "PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724952", "map_id": "none", "name": "Homologues of PolyUb-Misfolded CETN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724944", "map_id": "none", "name": "UBE2N:UBE2V1:PRKN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725708", "map_id": "none", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725652", "map_id": "none", "name": "ATM:PEX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725677", "map_id": "none", "name": "ATM:PEX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10725712", "map_id": "none", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725659", "map_id": "Q55CE3", "name": "SQSTM1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10725669", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10725671", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10724932", "map_id": "none", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689017", "map_id": "none", "name": "Homologues of PARK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724928", "map_id": "none", "name": "Ub:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724930", "map_id": "none", "name": "Ub:UBE2N:UBE2V1:PRKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10704855", "map_id": "none", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703627", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10704852", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54UG7", "map_id": "Q54UG7", "name": "PRKAB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281089", "map_id": "DDB_G0281089", "name": "PRKAB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T277", "map_id": "Q8T277", "name": "prkag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272542", "map_id": "DDB_G0272542", "name": "prkag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703630", "map_id": "none", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10704806", "map_id": "none", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704781", "map_id": "none", "name": "CysO263-ATG3:LC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q550A8", "map_id": "Q550A8", "name": "atg3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277319", "map_id": "DDB_G0277319", "name": "atg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5681998", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10704783", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10704785", "map_id": "Q550A8", "name": "atg3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10704803", "map_id": "none", "name": "ATG16L1 complex:WIPI2:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54NA2", "map_id": "Q54NA2", "name": "atg18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285375", "map_id": "DDB_G0285375", "name": "atg18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O15736", "map_id": "O15736", "name": "tipD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275323", "map_id": "DDB_G0275323", "name": "tipD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725698", "map_id": "none", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10725661", "map_id": "Q553E9", "name": "smg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10725679", "map_id": "none", "name": "ATM dimer:PEX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_1250243", "map_id": "CHEBI:26523", "name": "ROS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10703598", "map_id": "none", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703495", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10703595", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10704672", "map_id": "none", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10704214", "map_id": "none", "name": "MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677585", "map_id": "none", "name": "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10703610", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703639", "map_id": "none", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703473", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725696", "map_id": "none", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10725692", "map_id": "Q54Q21", "name": "Q54Q21", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "species_10725694", "map_id": "none", "name": "NBR1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10721810", "map_id": "none", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721808", "map_id": "Q75K07", "name": "phospho-p-S13-FUNDC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10697880", "map_id": "none", "name": "Casein kinase II", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LR6", "map_id": "Q54LR6", "name": "CSNK2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286481", "map_id": "DDB_G0286481", "name": "CSNK2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02720", "map_id": "Q02720", "name": "casK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276885", "map_id": "DDB_G0276885", "name": "casK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PF1", "map_id": "Q54PF1", "name": "csnk2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284601", "map_id": "DDB_G0284601", "name": "csnk2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704947", "map_id": "none", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704916", "map_id": "none", "name": "LC3 family precursors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704773", "map_id": "none", "name": "LC3 family", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704944", "map_id": "none", "name": "ATG4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557H7", "map_id": "Q557H7", "name": "atg4-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273443", "map_id": "DDB_G0273443", "name": "atg4-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM7", "map_id": "Q54QM7", "name": "ATG4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283753", "map_id": "DDB_G0283753", "name": "ATG4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725687", "map_id": "none", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10725685", "map_id": "none", "name": "ATM dimer:p-PEX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10705356", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704862", "map_id": "none", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704681", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723993", "map_id": "none", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704874", "map_id": "none", "name": "ATG12:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86CR9", "map_id": "Q86CR9", "name": "atg7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271096", "map_id": "DDB_G0271096", "name": "atg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10705267", "map_id": "none", "name": "ATG12:ATG7:CysO572-ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724970", "map_id": "none", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704216", "map_id": "none", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683107", "map_id": "none", "name": "p-AMPK heterotrimer:AMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10704876", "map_id": "none", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704872", "map_id": "none", "name": "ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704792", "map_id": "Q86CR6", "name": "atg12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10705132", "map_id": "none", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704949", "map_id": "none", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704883", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725706", "map_id": "none", "name": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10704704", "map_id": "none", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704700", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54SA0", "map_id": "Q54SA0", "name": "WDR45B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282581", "map_id": "DDB_G0282581", "name": "WDR45B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693050", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10704702", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806159", "map_id": "CHEBI:17283", "name": "PI3P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10705183", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10705174", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10705181", "map_id": "none", "name": "UVRAG complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JC5", "map_id": "Q54JC5", "name": "UVRAG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288175", "map_id": "DDB_G0288175", "name": "UVRAG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687292", "map_id": "none", "name": "ESCRT-III", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KZ4", "map_id": "Q54KZ4", "name": "chmp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287021", "map_id": "DDB_G0287021", "name": "chmp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JK4", "map_id": "Q54JK4", "name": "chmp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287993", "map_id": "DDB_G0287993", "name": "chmp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P63", "map_id": "Q54P63", "name": "chmp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284769", "map_id": "DDB_G0284769", "name": "chmp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H98", "map_id": "Q86H98", "name": "chmp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275573", "map_id": "DDB_G0275573", "name": "chmp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GK9", "map_id": "Q54GK9", "name": "chmp2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290087", "map_id": "DDB_G0290087", "name": "chmp2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704864", "map_id": "none", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704801", "map_id": "none", "name": "WIPI2:PI(3,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10704799", "map_id": "none", "name": "ATG16L1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10705335", "map_id": "none", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704887", "map_id": "none", "name": "LC3:CysO263-ATG3:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725710", "map_id": "none", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10703498", "map_id": "none", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703475", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725654", "map_id": "none", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724145", "map_id": "Q54MD1", "name": "pex5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10725650", "map_id": "Q553E9", "name": "smg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10705269", "map_id": "none", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10704885", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7:ATG3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724942", "map_id": "none", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724938", "map_id": "none", "name": "Homologues of Misfolded CETN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725675", "map_id": "none", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10725673", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10705145", "map_id": "none", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10705136", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10705141", "map_id": "Q54NA3", "name": "atg9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "DDB_G0285323", "map_id": "DDB_G0285323", "name": "atg9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703617", "map_id": "none", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704890", "map_id": "none", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704684", "map_id": "none", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10714394", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714372", "map_id": "none", "name": "ETF1 dimer:eRF3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9BMX0", "map_id": "Q9BMX0", "name": "erf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288613", "map_id": "DDB_G0288613", "name": "erf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YZN9", "map_id": "Q7YZN9", "name": "erf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277919", "map_id": "DDB_G0277919", "name": "erf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714379", "map_id": "none", "name": "Me-Q185-ETF1 dimer:eRF3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10714391", "map_id": "none", "name": "N6AMT1:TRMT112", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N57", "map_id": "Q54N57", "name": "TRMT112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285489", "map_id": "DDB_G0285489", "name": "TRMT112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DT3", "map_id": "Q54DT3", "name": "N6AMT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292048", "map_id": "DDB_G0292048", "name": "N6AMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709680", "map_id": "none", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691496", "map_id": "none", "name": "NAc-Ser:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5691517", "map_id": "CHEBI:83690", "name": "NAc-Ser residue", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785226", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10709677", "map_id": "Q55GA9", "name": "APEH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267742", "map_id": "DDB_G0267742", "name": "APEH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725743", "map_id": "none", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683047", "map_id": "none", "name": "Microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P32255", "map_id": "P32255", "name": "tubA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287689", "map_id": "DDB_G0287689", "name": "tubA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32256", "map_id": "P32256", "name": "tubB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269196", "map_id": "DDB_G0269196", "name": "tubB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TA6", "map_id": "Q54TA6", "name": "TUBA1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281889", "map_id": "DDB_G0281889", "name": "TUBA1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683043", "map_id": "none", "name": "alpha-beta tubulin dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725732", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54KQ7", "map_id": "Q54KQ7", "name": "SPAST", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287165", "map_id": "DDB_G0287165", "name": "SPAST", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QK5", "map_id": "Q54QK5", "name": "CC2D1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283793", "map_id": "DDB_G0283793", "name": "CC2D1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I39", "map_id": "Q54I39", "name": "IST1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289029", "map_id": "DDB_G0289029", "name": "IST1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725738", "map_id": "none", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10725728", "map_id": "none", "name": "LEMD2:ESCRT-III:IST1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10725722", "map_id": "Q54QK5", "name": "CC2D1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10725730", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10725736", "map_id": "none", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687703", "map_id": "Q54PT2", "name": "vps4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284347", "map_id": "DDB_G0284347", "name": "vps4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725734", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54PT2", "map_id": "Q54PT2", "name": "vps4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724709", "map_id": "none", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10681066", "map_id": "none", "name": "RAN:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P33519", "map_id": "P33519", "name": "ranA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291235", "map_id": "DDB_G0291235", "name": "ranA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724701", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724706", "map_id": "Q55C31", "name": "RCC1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "DDB_G0270246", "map_id": "DDB_G0270246", "name": "RCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698508", "map_id": "none", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10698318", "map_id": "none", "name": "SUMO1:C93-UBE2I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NGP4", "map_id": "Q9NGP4", "name": "ubc9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287693", "map_id": "DDB_G0287693", "name": "ubc9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698490", "map_id": "none", "name": "RANGAP1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54N16", "map_id": "Q54N16", "name": "SUMO1-K524-RANGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285563", "map_id": "DDB_G0285563", "name": "SUMO1-K524-RANGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698305", "map_id": "Q9NGP4", "name": "ubc9", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698505", "map_id": "none", "name": "SUMO1:RANGAP1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10724716", "map_id": "none", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724711", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_9624890", "map_id": "none", "name": "Fused nuclear envelope vesicles", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10725740", "map_id": "none", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725717", "map_id": "Q54KQ7", "name": "SPAST", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10724713", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10670890", "map_id": "none", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31221", "map_id": "CHEBI:18105", "name": "Fru 1-P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30393", "map_id": "CHEBI:17378", "name": "GA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10670880", "map_id": "none", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10670877", "map_id": "none", "name": "KHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D80", "map_id": "Q54D80", "name": "KHK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292440", "map_id": "DDB_G0292440", "name": "KHK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716376", "map_id": "none", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799497", "map_id": "CHEBI:32398", "name": "DGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671966", "map_id": "none", "name": "ALDH1A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IU0", "map_id": "Q54IU0", "name": "ALDH1A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290537", "map_id": "DDB_G0290537", "name": "ALDH1A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY2", "map_id": "Q54FY2", "name": "ALDH1A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY1", "map_id": "Q54FY1", "name": "ALDH1A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670900", "map_id": "none", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670897", "map_id": "none", "name": "TKFC:2Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EE0", "map_id": "Q55EE0", "name": "dhak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269274", "map_id": "DDB_G0269274", "name": "dhak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702192", "map_id": "none", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670557", "map_id": "none", "name": "PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54K47", "map_id": "Q54K47", "name": "pcna", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287607", "map_id": "DDB_G0287607", "name": "pcna", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702188", "map_id": "none", "name": "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GU9", "map_id": "Q55GU9", "name": "msh6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268614", "map_id": "DDB_G0268614", "name": "msh6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553L4", "map_id": "Q553L4", "name": "msh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275809", "map_id": "DDB_G0275809", "name": "msh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702174", "map_id": "none", "name": "MLH1:PMS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QA0", "map_id": "Q54QA0", "name": "pms1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283981", "map_id": "DDB_G0283981", "name": "pms1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KD8", "map_id": "Q54KD8", "name": "mlh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287393", "map_id": "DDB_G0287393", "name": "mlh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702190", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702289", "map_id": "none", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702167", "map_id": "Q54KD8", "name": "mlh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10702172", "map_id": "Q54QA0", "name": "pms1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10702208", "map_id": "none", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702205", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702287", "map_id": "none", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702179", "map_id": "Q553L4", "name": "msh2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10702184", "map_id": "Q55GU9", "name": "msh6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10702210", "map_id": "none", "name": "MSH2:MSH6:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702227", "map_id": "none", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702212", "map_id": "none", "name": "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702285", "map_id": "none", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702197", "map_id": "Q1ZXH0", "name": "msh3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281683", "map_id": "DDB_G0281683", "name": "msh3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702199", "map_id": "none", "name": "MSH2:MSH3:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXH0", "map_id": "Q1ZXH0", "name": "msh3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702203", "map_id": "none", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358527", "map_id": "none", "name": "DNA containing IDL of 2 or more bases", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10702201", "map_id": "none", "name": "MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702216", "map_id": "none", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358610", "map_id": "none", "name": "DNA containing single strand nick (5' phosphate, 3' hydroxyl)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_109966", "map_id": "none", "name": "Repaired double-stranded DNA", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_164121", "map_id": "CHEBI:456215", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113541", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670614", "map_id": "Q869E1", "name": "lig1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0274493", "map_id": "DDB_G0274493", "name": "lig1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702214", "map_id": "none", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358514", "map_id": "none", "name": "DNA containing mismatch or 1-2 base IDL", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10702225", "map_id": "none", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702221", "map_id": "Q54ED2", "name": "exo1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10702223", "map_id": "none", "name": "EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675582", "map_id": "none", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675580", "map_id": "none", "name": "Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55G81", "map_id": "Q55G81", "name": "repD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267414", "map_id": "DDB_G0267414", "name": "repD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EH2", "map_id": "Q54EH2", "name": "polr2e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291636", "map_id": "DDB_G0291636", "name": "polr2e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YW8", "map_id": "Q54YW8", "name": "polr2h", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278039", "map_id": "DDB_G0278039", "name": "polr2h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DH7", "map_id": "Q54DH7", "name": "polr2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292244", "map_id": "DDB_G0292244", "name": "polr2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JJ5", "map_id": "Q86JJ5", "name": "polr2j", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277677", "map_id": "DDB_G0277677", "name": "polr2j", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35084", "map_id": "P35084", "name": "phospho-polr2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279193", "map_id": "DDB_G0279193", "name": "phospho-polr2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GG8", "map_id": "Q55GG8", "name": "rpb9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268306", "map_id": "DDB_G0268306", "name": "rpb9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F19", "map_id": "Q55F19", "name": "cycH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268668", "map_id": "DDB_G0268668", "name": "cycH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AB6", "map_id": "Q55AB6", "name": "polr2l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272036", "map_id": "DDB_G0272036", "name": "polr2l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FA8", "map_id": "Q54FA8", "name": "polr2f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291037", "map_id": "DDB_G0291037", "name": "polr2f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IB5", "map_id": "Q86IB5", "name": "gtf2h3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275517", "map_id": "DDB_G0275517", "name": "gtf2h3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00835", "map_id": "O00835", "name": "repB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278729", "map_id": "DDB_G0278729", "name": "repB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I13", "map_id": "Q54I13", "name": "mnat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289079", "map_id": "DDB_G0289079", "name": "mnat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54685", "map_id": "P54685", "name": "cdk7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285417", "map_id": "DDB_G0285417", "name": "cdk7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R66", "map_id": "Q54R66", "name": "polr2k", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283365", "map_id": "DDB_G0283365", "name": "polr2k", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WV4", "map_id": "Q54WV4", "name": "gtf2f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279377", "map_id": "DDB_G0279377", "name": "gtf2f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P04", "map_id": "Q54P04", "name": "polr2g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284891", "map_id": "DDB_G0284891", "name": "polr2g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S04", "map_id": "Q54S04", "name": "polr2d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282739", "map_id": "DDB_G0282739", "name": "polr2d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KZ2", "map_id": "Q86KZ2", "name": "gtf2h2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272362", "map_id": "DDB_G0272362", "name": "gtf2h2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C29", "map_id": "Q54C29", "name": "gtf2h4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293228", "map_id": "DDB_G0293228", "name": "gtf2h4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CT8", "map_id": "Q55CT8", "name": "gtf2h5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269906", "map_id": "DDB_G0269906", "name": "gtf2h5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KT7", "map_id": "Q54KT7", "name": "gtf2f2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287131", "map_id": "DDB_G0287131", "name": "gtf2f2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J75", "map_id": "Q54J75", "name": "polr2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288257", "map_id": "DDB_G0288257", "name": "polr2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FP1", "map_id": "Q55FP1", "name": "gtf2h1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268014", "map_id": "DDB_G0268014", "name": "gtf2h1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675574", "map_id": "Q54HV6", "name": "RNGTT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289199", "map_id": "DDB_G0289199", "name": "RNGTT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675576", "map_id": "none", "name": "RNA Pol II with phosphorylated CTD: CE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HV6", "map_id": "Q54HV6", "name": "RNGTT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675587", "map_id": "none", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675584", "map_id": "none", "name": "Pol II transcription complex containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676478", "map_id": "none", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10675602", "map_id": "none", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675592", "map_id": "Q54Y13", "name": "RNMT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0278479", "map_id": "DDB_G0278479", "name": "RNMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675598", "map_id": "Q54K42", "name": "phospho-p-SUPT5H", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287661", "map_id": "DDB_G0287661", "name": "phospho-p-SUPT5H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675600", "map_id": "none", "name": "CE:Pol II CTD:Spt5 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54Y13", "map_id": "Q54Y13", "name": "RNMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K42", "map_id": "Q54K42", "name": "phospho-p-SUPT5H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675578", "map_id": "none", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10670593", "map_id": "none", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670586", "map_id": "none", "name": "Processive complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BM5", "map_id": "Q55BM5", "name": "prim2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270442", "map_id": "DDB_G0270442", "name": "prim2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MM7", "map_id": "Q54MM7", "name": "PRIM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285853", "map_id": "DDB_G0285853", "name": "PRIM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TN8", "map_id": "Q54TN8", "name": "POLD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281641", "map_id": "DDB_G0281641", "name": "POLD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N97", "map_id": "Q54N97", "name": "pold1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285381", "map_id": "DDB_G0285381", "name": "pold1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S08", "map_id": "Q54S08", "name": "polA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282731", "map_id": "DDB_G0282731", "name": "polA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SV8", "map_id": "Q54SV8", "name": "pola1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282191", "map_id": "DDB_G0282191", "name": "pola1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G131", "map_id": "B0G131", "name": "POLD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294609", "map_id": "DDB_G0294609", "name": "POLD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670590", "map_id": "none", "name": "Processive complex:Okazaki fragment complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670584", "map_id": "none", "name": "DNA Polymerase delta tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670597", "map_id": "none", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670595", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670617", "map_id": "none", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68452", "map_id": "none", "name": "Okazaki fragment", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_69172", "map_id": "none", "name": "ligated okazaki fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10670609", "map_id": "none", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670599", "map_id": "none", "name": "Processive complex:Okazaki fragments:Remaining Flap", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670601", "map_id": "none", "name": "Processive complex:nicked DNA from adjacent Okazaki fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670606", "map_id": "Q54NU0", "name": "repG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284987", "map_id": "DDB_G0284987", "name": "repG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688208", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_915149", "map_id": "CHEBI:59092", "name": "(GlcNAc)2 (Man)9", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_964740", "map_id": "CHEBI:59087", "name": "(GlcNAc)2 (Man)5 (Asn)1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_964752", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10688205", "map_id": "none", "name": "MAN1A1/A2/C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55EU0", "map_id": "Q55EU0", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292918", "map_id": "DDB_G0292918", "name": "MAN1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ1", "map_id": "Q54PQ1", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ0", "map_id": "Q54PQ0", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PP9", "map_id": "Q54PP9", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CH4", "map_id": "Q54CH4", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688218", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964831", "map_id": "none", "name": "(GlcNAc)2 (Man)8 glycans", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688220", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964828", "map_id": "CHEBI:60637", "name": "(GlcNAc)2 (Man)7bc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10688216", "map_id": "none", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964837", "map_id": "CHEBI:60625", "name": "(GlcNAc)3 (Man)5 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10688213", "map_id": "Q54IX1", "name": "gnt3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "DDB_G0288463", "map_id": "DDB_G0288463", "name": "gnt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686090", "map_id": "none", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686088", "map_id": "none", "name": "Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86I71", "map_id": "Q86I71", "name": "Ub-HNRNPD-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275027", "map_id": "DDB_G0275027", "name": "Ub-HNRNPD-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670356", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QR2", "map_id": "Q54QR2", "name": "psmB7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283679", "map_id": "DDB_G0283679", "name": "psmB7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A21", "map_id": "Q86A21", "name": "psmB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272969", "map_id": "DDB_G0272969", "name": "psmB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34124", "map_id": "P34124", "name": "psmC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292382", "map_id": "DDB_G0292382", "name": "psmC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM7", "map_id": "Q54DM7", "name": "psmA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292122", "map_id": "DDB_G0292122", "name": "psmA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UJ0", "map_id": "Q54UJ0", "name": "psmD12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281051", "map_id": "DDB_G0281051", "name": "psmD12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BV5", "map_id": "Q55BV5", "name": "psmC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270784", "map_id": "DDB_G0270784", "name": "psmC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DB2", "map_id": "Q54DB2", "name": "PSME4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292398", "map_id": "DDB_G0292398", "name": "PSME4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G04", "map_id": "Q55G04", "name": "psmA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268538", "map_id": "DDB_G0268538", "name": "psmA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XM7", "map_id": "Q54XM7", "name": "psmA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278847", "map_id": "DDB_G0278847", "name": "psmA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IJ1", "map_id": "Q86IJ1", "name": "psmD14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272566", "map_id": "DDB_G0272566", "name": "psmD14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C75", "map_id": "Q55C75", 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"gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34123", "map_id": "P34123", "name": "psmC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289003", "map_id": "DDB_G0289003", "name": "psmC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D66", "map_id": "Q55D66", "name": "psmB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269772", "map_id": "DDB_G0269772", "name": "psmB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q967U1", "map_id": "Q967U1", "name": "psmE3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285099", "map_id": "DDB_G0285099", "name": "psmE3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB0", "map_id": "Q54MB0", "name": "PSMD10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286067", "map_id": "DDB_G0286067", "name": "PSMD10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27563", "map_id": "Q27563", "name": "psmA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267408", "map_id": "DDB_G0267408", "name": "psmA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Q0", "map_id": "Q556Q0", "name": "psmB4-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273163", "map_id": "DDB_G0273163", "name": "psmB4-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34120", "map_id": "P34120", "name": "psmA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272831", "map_id": "DDB_G0272831", "name": "psmA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JA1", "map_id": "Q86JA1", "name": "psmC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276917", "map_id": "DDB_G0276917", "name": "psmC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553E0", "map_id": "Q553E0", "name": "psmD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275775", "map_id": "DDB_G0275775", "name": "psmD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UB5", "map_id": "Q54UB5", "name": "psmD11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281315", "map_id": "DDB_G0281315", "name": "psmD11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34119", "map_id": "P34119", "name": "psmA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280969", "map_id": "DDB_G0280969", "name": "psmA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BC8", "map_id": "Q54BC8", "name": "psmB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293784", "map_id": "DDB_G0293784", "name": "psmB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S82", "map_id": "Q54S82", "name": "PSMF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282617", "map_id": "DDB_G0282617", "name": "PSMF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ1", "map_id": "Q54PJ1", "name": "psmC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284517", "map_id": "DDB_G0284517", "name": "psmC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WI8", "map_id": "Q54WI8", "name": "psmD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279633", "map_id": "DDB_G0279633", "name": "psmD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559F4", "map_id": "Q559F4", "name": "PSMD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272951", "map_id": "DDB_G0272951", "name": "PSMD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GJ6", "map_id": "Q55GJ6", "name": "psmB6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267390", "map_id": "DDB_G0267390", "name": "psmB6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DY7", "map_id": "Q55DY7", "name": "psmB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269472", "map_id": "DDB_G0269472", "name": "psmB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD3", "map_id": "Q1ZXD3", "name": "psmD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288621", "map_id": "DDB_G0288621", "name": "psmD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02889", "map_id": "P02889", "name": "psmD8-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272564", "map_id": "DDB_G0272564", "name": "psmD8-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BC6", "map_id": "Q54BC6", "name": "psmD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293752", "map_id": "DDB_G0293752", "name": "psmD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JM5", "map_id": "Q54JM5", "name": "psmD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287953", "map_id": "DDB_G0287953", "name": "psmD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552Y8", "map_id": "Q552Y8", "name": "psmD9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275753", "map_id": "DDB_G0275753", "name": "psmD9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27562", "map_id": "Q27562", "name": "psmA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282363", "map_id": "DDB_G0282363", "name": "psmA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686077", "map_id": "none", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686071", "map_id": "none", "name": "AUF1 Dimer (isoform p37 or p40)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_450444", "map_id": "none", "name": "mRNA Transcript Targeted by AUF1(hnRNP D0)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686075", "map_id": "none", "name": "AUF1 Tetramer: Destabilized mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686313", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686265", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "Q55FE2", "map_id": "Q55FE2", "name": "TOR1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268156", "map_id": "DDB_G0268156", "name": "TOR1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05095", "map_id": "P05095", "name": "abpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268632", "map_id": "DDB_G0268632", "name": "abpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DM8", "map_id": "Q55DM8", "name": "SRGN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269600", "map_id": "DDB_G0269600", "name": "SRGN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V78", "map_id": "Q54V78", "name": "ACTN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0349530", "map_id": "DDB_G0349530", "name": "ACTN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PA3", "map_id": "Q54PA3", "name": "MAGED2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284679", "map_id": "DDB_G0284679", "name": "MAGED2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553C3", "map_id": "Q553C3", "name": "VTI1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275765", "map_id": "DDB_G0275765", "name": "VTI1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D77", "map_id": "Q54D77", "name": "GTPBP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292538", "map_id": "DDB_G0292538", "name": "GTPBP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2H0", "map_id": "Q8T2H0", "name": "cyri", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272190", "map_id": "DDB_G0272190", "name": "cyri", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q34", "map_id": "Q54Q34", "name": "ACTN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KR6", "map_id": "Q54KR6", "name": "PCYOX1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287201", "map_id": "DDB_G0287201", "name": "PCYOX1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ET7", "map_id": "Q55ET7", "name": "OLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268758", "map_id": "DDB_G0268758", "name": "OLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686311", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10686448", "map_id": "none", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686424", "map_id": "none", "name": "Homologues of RAB27B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "Q54FL2", "map_id": "Q54FL2", "name": "rabG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290783", "map_id": "DDB_G0290783", "name": "rabG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EF0", "map_id": "Q55EF0", "name": "rabT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269262", "map_id": "DDB_G0269262", "name": "rabT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T193", "map_id": "Q8T193", "name": "RAB35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294569", "map_id": "DDB_G0294569", "name": "RAB35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JC8", "map_id": "Q86JC8", "name": "rabH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275955", "map_id": "DDB_G0275955", "name": "rabH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E92", "map_id": "Q54E92", "name": "rabG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291738", "map_id": "DDB_G0291738", "name": "rabG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JP5", "map_id": "Q86JP5", "name": "rabR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271980", "map_id": "DDB_G0271980", "name": "rabR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S63", "map_id": "Q54S63", "name": "rsmN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282651", "map_id": "DDB_G0282651", "name": "rsmN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXN9", "map_id": "Q1ZXN9", "name": "RAB35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EG6", "map_id": "Q55EG6", "name": "rabT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268910", "map_id": "DDB_G0268910", "name": "rabT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S62", "map_id": "Q54S62", "name": "RAB35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686446", "map_id": "none", "name": "Homologues of RAB27B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682506", "map_id": "none", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10682498", "map_id": "none", "name": "PSAP,CHID1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q55EI1", "map_id": "Q55EI1", "name": "PSAP(60-142)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268890", "map_id": "DDB_G0268890", "name": "PSAP(60-142)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G42", "map_id": "Q54G42", "name": "chid1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290417", "map_id": "DDB_G0290417", "name": "chid1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682504", "map_id": "none", "name": "PSAP,CHID1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10686372", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686352", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "P04988", "map_id": "P04988", "name": "cprA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290957", "map_id": "DDB_G0290957", "name": "cprA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15996", "map_id": "CHEBI:15996", "name": "CHEBI:15996", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_111349", "map_id": "CHEBI:17552", "name": "GDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54TR1", "map_id": "Q54TR1", "name": "cfaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281605", "map_id": "DDB_G0281605", "name": "cfaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F16", "map_id": "Q54F16", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291191", "map_id": "DDB_G0291191", "name": "CTSW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559Q3", "map_id": "Q559Q3", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QD9", "map_id": "Q54QD9", "name": "ctsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283921", "map_id": "DDB_G0283921", "name": "ctsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB6", "map_id": "Q54MB6", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686370", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10686484", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686472", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "Q55FQ9", "map_id": "Q55FQ9", "name": "lmpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267440", "map_id": "DDB_G0267440", "name": "lmpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RR0", "map_id": "Q54RR0", "name": "JFC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282977", "map_id": "DDB_G0282977", "name": "JFC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKJ9", "map_id": "Q9BKJ9", "name": "lmpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287035", "map_id": "DDB_G0287035", "name": "lmpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NC1", "map_id": "Q54NC1", "name": "cyb5r1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285399", "map_id": "DDB_G0285399", "name": "cyb5r1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XV1", "map_id": "Q54XV1", "name": "CYB5R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278567", "map_id": "DDB_G0278567", "name": "CYB5R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYS8", "map_id": "Q9XYS8", "name": "lmpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267406", "map_id": "DDB_G0267406", "name": "lmpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686482", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10686628", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686552", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HE7", "map_id": "Q54HE7", "name": "act28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289511", "map_id": "DDB_G0289511", "name": "act28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW0", "map_id": "Q54PW0", "name": "PRNP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284261", "map_id": "DDB_G0284261", "name": "PRNP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W22", "map_id": "Q54W22", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282287", "map_id": "DDB_G0282287", "name": "PLEK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GX7", "map_id": "Q54GX7", "name": "act10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289811", "map_id": "DDB_G0289811", "name": "act10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07830", "map_id": "P07830", "name": "act9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269234", "map_id": "DDB_G0269234", "name": "act9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HE9", "map_id": "Q54HE9", "name": "act27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289533", "map_id": "DDB_G0289533", "name": "act27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554S6", "map_id": "Q554S6", "name": "act17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274131", "map_id": "DDB_G0274131", "name": "act17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST8", "map_id": "Q54ST8", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P24639", "map_id": "P24639", "name": "nxnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269160", "map_id": "DDB_G0269160", "name": "nxnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553U6", "map_id": "Q553U6", "name": "act22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275023", "map_id": "DDB_G0275023", "name": "act22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551W8", "map_id": "Q551W8", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU6", "map_id": "Q55EU6", "name": "act23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268744", "map_id": "DDB_G0268744", "name": "act23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07829", "map_id": "P07829", "name": "act3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289487", "map_id": "DDB_G0289487", "name": "act3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DY5", "map_id": "Q55DY5", "name": "ACTG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287981", "map_id": "DDB_G0287981", "name": "ACTG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DS6", "map_id": "Q55DS6", "name": "ACTG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556T3", "map_id": "Q556T3", "name": "fip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273107", "map_id": "DDB_G0273107", "name": "fip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54686", "map_id": "P54686", "name": "aip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278733", "map_id": "DDB_G0278733", "name": "aip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JL1", "map_id": "Q54JL1", "name": "ACTG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GQ5", "map_id": "Q55GQ5", "name": "sodA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267420", "map_id": "DDB_G0267420", "name": "sodA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF1", "map_id": "Q54HF1", "name": "act24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289505", "map_id": "DDB_G0289505", "name": "act24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JD4", "map_id": "Q54JD4", "name": "HABP4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288133", "map_id": "DDB_G0288133", "name": "HABP4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K81", "map_id": "Q54K81", "name": "talB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287505", "map_id": "DDB_G0287505", "name": "talB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CU2", "map_id": "Q55CU2", "name": "act26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269902", "map_id": "DDB_G0269902", "name": "act26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07828", "map_id": "P07828", "name": "act18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289489", "map_id": "DDB_G0289489", "name": "act18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF0", "map_id": "Q54HF0", "name": "act25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289507", "map_id": "DDB_G0289507", "name": "act25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686626", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10701635", "map_id": "none", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701632", "map_id": "none", "name": "RASA1:p21 RAS:GTP:SPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8SSU4", "map_id": "Q8SSU4", "name": "RASA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274211", "map_id": "DDB_G0274211", "name": "RASA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428193", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679174", "map_id": "Q8SSU4", "name": "RASA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10701626", "map_id": "Q6B516", "name": "phospho-sgkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284545", "map_id": "DDB_G0284545", "name": "sgkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725915", "map_id": "none", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725899", "map_id": "none", "name": "p-Y705,S727-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725913", "map_id": "none", "name": "p-Y705,S727-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10725936", "map_id": "none", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10725931", "map_id": "none", "name": "AcK685- p-Y705,S727-STAT3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427486", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10725933", "map_id": "none", "name": "Histone deacetylase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BW2", "map_id": "Q55BW2", "name": "hdaB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270338", "map_id": "DDB_G0270338", "name": "hdaB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677104", "map_id": "none", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677101", "map_id": "Q23917", "name": "phospho-regA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675817", "map_id": "none", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10675791", "map_id": "none", "name": "AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10675814", "map_id": "none", "name": "p-T309,S474-AKT2:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10675800", "map_id": "none", "name": "PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TW2", "map_id": "Q54TW2", "name": "pdkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281471", "map_id": "DDB_G0281471", "name": "pdkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680170", "map_id": "none", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680149", "map_id": "none", "name": "AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10680079", "map_id": "none", "name": "p-S-AKT:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10680163", "map_id": "none", "name": "TORC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O77203", "map_id": "O77203", "name": "piaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277399", "map_id": "DDB_G0277399", "name": "piaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0C9", "map_id": "Q9Y0C9", "name": "ripA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284611", "map_id": "DDB_G0284611", "name": "ripA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680168", "map_id": "none", "name": "AKT:PIP3:THEM4/TRIB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q556W3", "map_id": "Q556W3", "name": "THEM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273293", "map_id": "DDB_G0273293", "name": "THEM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697254", "map_id": "none", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10680081", "map_id": "none", "name": "p-S-AKT:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10697252", "map_id": "none", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680825", "map_id": "Q54TW2", "name": "pdkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10725901", "map_id": "none", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725897", "map_id": "none", "name": "Homologues of p-Y705,S727-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674483", "map_id": "none", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_74722", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10674480", "map_id": "none", "name": "V-ATPase:ATP6AP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "P54641", "map_id": "P54641", "name": "vatD-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273071", "map_id": "DDB_G0273071", "name": "vatD-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AH5", "map_id": "Q55AH5", "name": "vatF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271882", "map_id": "DDB_G0271882", "name": "vatF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54648", "map_id": "P54648", "name": "vatC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284473", "map_id": "DDB_G0284473", "name": "vatC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A77", "map_id": "Q86A77", "name": "atp6v1d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274331", "map_id": "DDB_G0274331", "name": "atp6v1d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54647", "map_id": "P54647", "name": "vatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287127", "map_id": "DDB_G0287127", "name": "vatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MML6", "map_id": "Q8MML6", "name": "vatH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274553", "map_id": "DDB_G0274553", "name": "vatH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54642", "map_id": "P54642", "name": "vatP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274381", "map_id": "DDB_G0274381", "name": "vatP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00780", "map_id": "O00780", "name": "vatE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275701", "map_id": "DDB_G0275701", "name": "vatE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NU1", "map_id": "Q76NU1", "name": "vatB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277401", "map_id": "DDB_G0277401", "name": "vatB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E04", "map_id": "Q54E04", "name": "vatM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291858", "map_id": "DDB_G0291858", "name": "vatM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z13", "map_id": "Q54Z13", "name": "atp6v1g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277971", "map_id": "DDB_G0277971", "name": "atp6v1g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AS7", "map_id": "Q86AS7", "name": "ATP6V0B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274141", "map_id": "DDB_G0274141", "name": "ATP6V0B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690303", "map_id": "none", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10690293", "map_id": "none", "name": "Homologues of USP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PQ7", "map_id": "Q54PQ7", "name": "phospho-p-T945-USP8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293770", "map_id": "DDB_G0293770", "name": "phospho-p-T945-USP8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G199", "map_id": "B0G199", "name": "phospho-p-T945-USP8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690301", "map_id": "none", "name": "Homologues of p-T945-USP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680099", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680102", "map_id": "none", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675793", "map_id": "none", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10675789", "map_id": "none", "name": "AKT2:THEM4,TRIB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10675775", "map_id": "Q556W3", "name": "THEM4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10714853", "map_id": "none", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672464", "map_id": "Q54PW8", "name": "PTBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284321", "map_id": "DDB_G0284321", "name": "PTBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672420", "map_id": "Q54VI2", "name": "HNRNPA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0280393", "map_id": "DDB_G0280393", "name": "HNRNPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714849", "map_id": "none", "name": "capped, methylated pre-FGFR2 mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10714851", "map_id": "none", "name": "FGFR2 IIIc-specific splicing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PW8", "map_id": "Q54PW8", "name": "PTBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VI2", "map_id": "Q54VI2", "name": "HNRNPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675802", "map_id": "none", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10675798", "map_id": "Q54TW2", "name": "pdkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10693751", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1629765", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693540", "map_id": "none", "name": "IP6K1/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QM1", "map_id": "Q54QM1", "name": "IP6K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293860", "map_id": "DDB_G0293860", "name": "IP6K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XR3", "map_id": "Q54XR3", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278739", "map_id": "DDB_G0278739", "name": "IP6K1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AP4", "map_id": "Q55AP4", "name": "IP6K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B75", "map_id": "Q54B75", "name": "IP6K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693634", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629732", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693551", "map_id": "none", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994149", "map_id": "CHEBI:15844", "name": "I(3,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994141", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693545", "map_id": "none", "name": "ITPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55D87", "map_id": "Q55D87", "name": "ITPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269746", "map_id": "DDB_G0269746", "name": "ITPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693631", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629736", "map_id": "CHEBI:62926", "name": "1-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693543", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693711", "map_id": "none", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10693620", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693617", "map_id": "Q54J22", "name": "IPPK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288351", "map_id": "DDB_G0288351", "name": "IPPK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693742", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629755", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10690279", "map_id": "none", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690276", "map_id": "none", "name": "TALK 1and 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10690258", "map_id": "none", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690255", "map_id": "none", "name": "TRESK homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10690146", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690143", "map_id": "Q55CX3", "name": "KCNN4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0269864", "map_id": "DDB_G0269864", "name": "KCNN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690247", "map_id": "none", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690244", "map_id": "none", "name": "TASK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10690159", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690156", "map_id": "none", "name": "Small conductance Ca2+ activated potassium channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55CX3", "map_id": "Q55CX3", "name": "KCNN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690197", "map_id": "none", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690194", "map_id": "none", "name": "THIK1 homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10690226", "map_id": "none", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690223", "map_id": "none", "name": "TWIK channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10678283", "map_id": "none", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678272", "map_id": "none", "name": "G-protein alpha (i):GTP:Adenylate cyclase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10678254", "map_id": "none", "name": "G alpha-olf:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10678274", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684258", "map_id": "none", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682952", "map_id": "none", "name": "GABBR1:GABBR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54K09", "map_id": "Q54K09", "name": "grlQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287905", "map_id": "DDB_G0287905", "name": "grlQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F54", "map_id": "Q54F54", "name": "grlP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291095", "map_id": "DDB_G0291095", "name": "grlP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET0", "map_id": "Q54ET0", "name": "grlE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291356", "map_id": "DDB_G0291356", "name": "grlE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352003", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10682954", "map_id": "none", "name": "GABBR1:GABBR2:GABA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_916850", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10678281", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678278", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10678307", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678292", "map_id": "none", "name": "(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10678294", "map_id": "none", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678276", "map_id": "none", "name": "G alpha-olf:GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10678290", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10672907", "map_id": "none", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672894", "map_id": "Q54QF2", "name": "CWC25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283901", "map_id": "DDB_G0283901", "name": "CWC25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672779", "map_id": "none", "name": "Spliceosomal B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54Q46", "map_id": "Q54Q46", "name": "SNRPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284101", "map_id": "DDB_G0284101", "name": "SNRPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF6", "map_id": "Q1ZXF6", "name": "sf3b2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284555", "map_id": "DDB_G0284555", "name": "sf3b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JC5", "map_id": "Q86JC5", "name": "SF3B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275957", "map_id": "DDB_G0275957", "name": "SF3B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YX5", "map_id": "Q54YX5", "name": "2xMe-SNRPD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278027", "map_id": "DDB_G0278027", "name": "2xMe-SNRPD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WN2", "map_id": "Q54WN2", "name": "SNRNP27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279535", "map_id": "DDB_G0279535", "name": "SNRNP27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BU3", "map_id": "Q55BU3", "name": "BUD31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270360", "map_id": "DDB_G0270360", "name": "BUD31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PP4", "map_id": "Q54PP4", "name": "PHF5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284403", "map_id": "DDB_G0284403", "name": "PHF5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF6", "map_id": "Q54HF6", "name": "lsm7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289499", "map_id": "DDB_G0289499", "name": "lsm7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FQ0", "map_id": "Q55FQ0", "name": "snrnp70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268004", "map_id": "DDB_G0268004", "name": "snrnp70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NI62", "map_id": "Q9NI62", "name": "cypE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269216", "map_id": "DDB_G0269216", "name": "cypE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553S5", "map_id": "Q553S5", "name": "txnl4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275407", "map_id": "DDB_G0275407", "name": "txnl4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWK5", "map_id": "Q7KWK5", "name": "prp19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276803", "map_id": "DDB_G0276803", "name": "prp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DV7", "map_id": "Q54DV7", "name": "DDX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293064", "map_id": "DDB_G0293064", "name": "DDX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BG2", "map_id": "Q54BG2", "name": "SMNDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293636", "map_id": "DDB_G0293636", "name": "SMNDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EC6", "map_id": "Q55EC6", "name": "CD2BP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269300", "map_id": "DDB_G0269300", "name": "CD2BP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R72", "map_id": "Q54R72", "name": "EFTUD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283359", "map_id": "DDB_G0283359", "name": "EFTUD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2A7", "map_id": "Q8T2A7", "name": "PRPF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274213", "map_id": "DDB_G0274213", "name": "PRPF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TF6", "map_id": "Q54TF6", "name": "lsm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281779", "map_id": "DDB_G0281779", "name": "lsm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FZ3", "map_id": "Q54FZ3", "name": "RBM22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290649", "map_id": "DDB_G0290649", "name": "RBM22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K20", "map_id": "Q54K20", "name": "PRPF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287635", "map_id": "DDB_G0287635", "name": "PRPF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST0", "map_id": "Q54ST0", "name": "NHP2L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282243", "map_id": "DDB_G0282243", "name": "NHP2L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557T0", "map_id": "Q557T0", "name": "cwc15-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273383", "map_id": "DDB_G0273383", "name": "cwc15-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IV3", "map_id": "Q86IV3", "name": "PRPF38A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274361", "map_id": "DDB_G0274361", "name": "PRPF38A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LY9", "map_id": "Q54LY9", "name": "SF3B6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286297", "map_id": "DDB_G0286297", "name": "SF3B6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WZ0", "map_id": "Q54WZ0", "name": "cdc5l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279311", "map_id": "DDB_G0279311", "name": "cdc5l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M41", "map_id": "Q54M41", "name": "HNRNPM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286331", "map_id": "DDB_G0286331", "name": "HNRNPM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KX4", "map_id": "Q54KX4", "name": "lsm4", "type": 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"complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286395", "map_id": "DDB_G0286395", "name": "U2AF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A15", "map_id": "Q55A15", "name": "PRPF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272374", "map_id": "DDB_G0272374", "name": "PRPF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CI7", "map_id": "Q55CI7", "name": "CHERP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271014", "map_id": "DDB_G0271014", "name": "CHERP", "type": "gene_component", 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"false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TL3", "map_id": "Q54TL3", "name": "U2SURP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281687", "map_id": "DDB_G0281687", "name": "U2SURP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672899", "map_id": "Q55G43", "name": "CWC27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268358", "map_id": "DDB_G0268358", "name": "CWC27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672884", "map_id": "Q54MH3", "name": "dhx16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285937", "map_id": "DDB_G0285937", "name": "dhx16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672879", "map_id": "Q55D61", "name": "tifA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672889", "map_id": "Q54GS9", "name": "GPKOW", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289933", "map_id": "DDB_G0289933", "name": "GPKOW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672874", "map_id": "none", "name": "Cleavage and Polyadenylation Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LG7", "map_id": "Q54LG7", "name": "CSTF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286645", "map_id": "DDB_G0286645", "name": "CSTF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA3", "map_id": "Q55CA3", "name": "CPSF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270148", "map_id": "DDB_G0270148", "name": "CPSF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E68", "map_id": "Q55E68", "name": "nudt21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269370", "map_id": "DDB_G0269370", "name": "nudt21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XS9", "map_id": "Q54XS9", "name": "CSTF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278769", "map_id": "DDB_G0278769", "name": "CSTF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PX4", "map_id": "Q54PX4", "name": "SYMPK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284319", "map_id": "DDB_G0284319", "name": "SYMPK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZS8", "map_id": "Q54ZS8", "name": "pabpn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277371", "map_id": "DDB_G0277371", "name": "pabpn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BS1", "map_id": "Q55BS1", "name": "cpsf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270392", "map_id": "DDB_G0270392", "name": "cpsf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IF1", "map_id": "Q54IF1", "name": "FIP1L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288797", "map_id": "DDB_G0288797", "name": "FIP1L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TS6", "map_id": "Q54TS6", "name": "CPSF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281585", "map_id": "DDB_G0281585", "name": "CPSF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J73", "map_id": "Q54J73", "name": "papA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288259", "map_id": "DDB_G0288259", "name": "papA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WL8", "map_id": "Q54WL8", "name": "pcf11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279559", "map_id": "DDB_G0279559", "name": "pcf11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G084", "map_id": "C7G084", "name": "WDR33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295793", "map_id": "DDB_G0295793", "name": "WDR33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V94", "map_id": "Q54V94", "name": "CSTF2T", "type": "complex_component", "sub_type": "protein_component", "inferred": 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"compartment_display": "none" }, { "id": "species_10672755", "map_id": "Q86IV3", "name": "PRPF38A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672287", "map_id": "none", "name": "LSM2-8 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10672241", "map_id": "none", "name": "U4 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10672598", "map_id": "none", "name": "U1 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10672340", "map_id": "Q54WN2", "name": "SNRNP27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672335", "map_id": "Q54TQ2", "name": "SART1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672760", "map_id": "Q54LX5", "name": "WBP4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672345", "map_id": "Q54XH4", "name": "USP39", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672905", "map_id": "none", "name": "Spliceosomal Intermediate C (Bact) 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"name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676867", "map_id": "none", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672931", "map_id": "none", "name": "Magoh-Y14 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55E21", "map_id": "Q55E21", "name": "magoh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270866", "map_id": "DDB_G0270866", "name": "magoh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ME8", "map_id": "Q54ME8", "name": "RBM8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286007", "map_id": "DDB_G0286007", "name": "RBM8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676865", "map_id": "none", "name": "Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PG4", "map_id": "Q54PG4", "name": "SYF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284573", "map_id": "DDB_G0284573", "name": "SYF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F01", "map_id": "Q55F01", "name": "PPWD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269054", "map_id": "DDB_G0269054", "name": "PPWD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DH9", "map_id": "Q54DH9", "name": "UPF3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292240", "map_id": "DDB_G0292240", "name": "UPF3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10672949", "map_id": "none", "name": "pre-EJC:Spliceosomal C:pre-mRNP:CBC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10672912", "map_id": "none", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672909", "map_id": "none", "name": "Spliceosomal Active C (B*) Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10683372", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683362", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NA13", "map_id": "Q9NA13", "name": "iplA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292564", "map_id": "DDB_G0292564", "name": "iplA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683370", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10683430", "map_id": "none", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10683426", "map_id": "none", "name": "Homologues of RAPGEF3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10683428", "map_id": "none", "name": "RAPGEF3:cAMP complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10683348", "map_id": "none", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10683344", "map_id": "none", "name": "Homologues of RAPGEF4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10683346", "map_id": "none", "name": "RAPGEF4:cAMP Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10683434", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683432", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10679921", "map_id": "none", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194691", "map_id": "CHEBI:18252", "name": "ZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_195691", "map_id": "CHEBI:16290", "name": "CHdOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679918", "map_id": "Q55E32", "name": "ebp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269414", "map_id": "DDB_G0269414", "name": "ebp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725767", "map_id": "none", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9673044", "map_id": "CHEBI:134020", "name": "oleoyl-Phe", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_109276", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351993", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9673048", "map_id": "CHEBI:30823", "name": "oleate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10725762", "map_id": "Q55DL1", "name": "PM20D1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0270582", "map_id": "DDB_G0270582", "name": "PM20D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725765", "map_id": "none", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10686978", "map_id": "none", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686974", "map_id": "P54651", "name": "hspD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686972", "map_id": "Q55ED0", "name": "sugt1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269292", "map_id": "DDB_G0269292", "name": "sugt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686976", "map_id": "none", "name": "SUGT1:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55ED0", "map_id": "Q55ED0", "name": "sugt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686985", "map_id": "none", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686982", "map_id": "none", "name": "ATP:P2X7 oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q553Y1", "map_id": "Q553Y1", "name": "p2xB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275293", "map_id": "DDB_G0275293", "name": "p2xB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553Y0", "map_id": "Q553Y0", "name": "p2xC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275191", "map_id": "DDB_G0275191", "name": "p2xC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JM7", "map_id": "Q86JM7", "name": "p2xA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272004", "map_id": "DDB_G0272004", "name": "p2xA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JH4", "map_id": "Q54JH4", "name": "p2xE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288061", "map_id": "DDB_G0288061", "name": "p2xE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J33", "map_id": "Q54J33", "name": "p2xD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288335", "map_id": "DDB_G0288335", "name": "p2xD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690134", "map_id": "none", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10690130", "map_id": "none", "name": "Homologues of TXNIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CH0", "map_id": "Q55CH0", "name": "adcC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271022", "map_id": "DDB_G0271022", "name": "adcC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CH1", "map_id": "Q54CH1", "name": "adcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292924", "map_id": "DDB_G0292924", "name": "adcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KB1", "map_id": "Q86KB1", "name": "adcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274395", "map_id": "DDB_G0274395", "name": "adcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HT7", "map_id": "Q54HT7", "name": "adcF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289229", "map_id": "DDB_G0289229", "name": "adcF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673826", "map_id": "none", "name": "Homologues of TXN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P29447", "map_id": "P29447", "name": "trxC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294489", "map_id": "DDB_G0294489", "name": "trxC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE0", "map_id": "Q1ZXE0", "name": "trxD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287849", "map_id": "DDB_G0287849", "name": "trxD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690132", "map_id": "none", "name": "Thioredoxin:TXNIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10690136", "map_id": "none", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673820", "map_id": "none", "name": "Homologues of 2xHC-TXN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684160", "map_id": "none", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_74112", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10684157", "map_id": "none", "name": "ATP2B1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54HG6", "map_id": "Q54HG6", "name": "ATP2B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289473", "map_id": "DDB_G0289473", "name": "ATP2B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54678", "map_id": "P54678", "name": "patA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277861", "map_id": "DDB_G0277861", "name": "patA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PE8", "map_id": "Q54PE8", "name": "ATP2B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711700", "map_id": "none", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment": "none", "compartment_display": "none" }, { "id": "Q54VT4", "map_id": "Q54VT4", "name": "ddx47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280147", "map_id": "DDB_G0280147", "name": "ddx47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XG2", "map_id": "Q54XG2", "name": "IMP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278983", "map_id": "DDB_G0278983", "name": "IMP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2Q3", "map_id": "Q8T2Q3", "name": "WDR43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285875", "map_id": "DDB_G0285875", "name": "heatr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S38", "map_id": "Q54S38", "name": "rcl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282803", "map_id": "DDB_G0282803", "name": "rcl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XT8", "map_id": "Q54XT8", "name": "RRP36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278751", "map_id": "DDB_G0278751", "name": "RRP36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CW0", "map_id": "Q55CW0", "name": "fbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269878", "map_id": "DDB_G0269878", "name": "fbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I41", "map_id": "Q54I41", "name": "rps7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289025", "map_id": "DDB_G0289025", "name": "rps7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D06", "map_id": "Q55D06", "name": "RRP7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"PDCD11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290181", "map_id": "DDB_G0290181", "name": "PDCD11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IZ9", "map_id": "Q86IZ9", "name": "ddx52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274325", "map_id": "DDB_G0274325", "name": "ddx52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S79", "map_id": "Q54S79", "name": "wdr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282623", "map_id": "DDB_G0282623", "name": "wdr3", "type": 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"complex": "true" }, { "id": "Q86IE2", "map_id": "Q86IE2", "name": "SKIV2L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275633", "map_id": "DDB_G0275633", "name": "SKIV2L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AW0", "map_id": "Q55AW0", "name": "exosc10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271572", "map_id": "DDB_G0271572", "name": "exosc10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZS3", "map_id": "Q54ZS3", "name": "MPHOSPH6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_display": "none" }, { "id": "DDB_G0270828", "map_id": "DDB_G0270828", "name": "AF037042_3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DG4", "map_id": "Q54DG4", "name": "SENP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292290", "map_id": "DDB_G0292290", "name": "SENP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JW2", "map_id": "Q75JW2", "name": "LAS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272176", "map_id": "DDB_G0272176", "name": "LAS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W52", "map_id": "Q54W52", "name": "wdr12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279903", "map_id": "DDB_G0279903", "name": "wdr12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IM3", "map_id": "Q54IM3", "name": "WDR18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288659", "map_id": "DDB_G0288659", "name": "WDR18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HJ2", "map_id": "Q54HJ2", "name": "PES1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289415", "map_id": "DDB_G0289415", "name": "PES1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z27", "map_id": "Q54Z27", "name": "nol9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277945", "map_id": "DDB_G0277945", "name": "nol9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W97", "map_id": "Q54W97", "name": "PELP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279809", "map_id": "DDB_G0279809", "name": "PELP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711387", "map_id": "none", "name": "28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10711383", "map_id": "Q54Z27", "name": "nol9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10711406", "map_id": "none", "name": "PeBoW complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10711378", "map_id": "Q75JW2", "name": "LAS1L", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10711422", "map_id": "none", "name": "GNL3:EBNA1BP2:DDX21:PES1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P34", "map_id": "Q54P34", "name": "EBNA1BP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284817", "map_id": "DDB_G0284817", "name": "EBNA1BP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KS4", "map_id": "Q54KS4", "name": "gnl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287147", "map_id": "DDB_G0287147", "name": "gnl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683571", "map_id": "none", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389556", "map_id": "CHEBI:18009", "name": "NADP+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389548", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113602", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389537", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683568", "map_id": "none", "name": "IDH1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q75JR2", "map_id": "Q75JR2", "name": "idhM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272210", "map_id": "DDB_G0272210", "name": "idhM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716318", "map_id": "none", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683769", "map_id": "none", "name": "Homologues of AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716315", "map_id": "none", "name": "PP2A-B56-beta,gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10692828", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10692825", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693245", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10692774", "map_id": "none", "name": "PIP5K1A-C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725879", "map_id": "none", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10683530", "map_id": "none", "name": "CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10725877", "map_id": "none", "name": "CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723407", "map_id": "none", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723403", "map_id": "none", "name": "CDC42 GDIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95UQ1", "map_id": "Q95UQ1", "name": "rdiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291077", "map_id": "DDB_G0291077", "name": "rdiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95UP9", "map_id": "Q95UP9", "name": "rdiB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280049", "map_id": "DDB_G0280049", "name": "rdiB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723395", "map_id": "none", "name": "CDC42:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723405", "map_id": "none", "name": "CDC42:GDP:CDC42 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723412", "map_id": "none", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723409", "map_id": "none", "name": "CDC42 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LN3", "map_id": "Q54LN3", "name": "Q54LN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286543", "map_id": "DDB_G0286543", "name": "Q54LN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG0", "map_id": "Q54NG0", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293396", "map_id": "DDB_G0293396", "name": "FGD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DW7", "map_id": "Q54DW7", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553D3", "map_id": "Q553D3", "name": "gxcJJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275679", "map_id": "DDB_G0275679", "name": "gxcJJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G10", "map_id": "Q54G10", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C56", "map_id": "Q54C56", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I66", "map_id": "Q86I66", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293084", "map_id": "DDB_G0293084", "name": "DOCK11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XW8", "map_id": "Q54XW8", "name": "gxcII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278703", "map_id": "DDB_G0278703", "name": "gxcII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GP2", "map_id": "Q54GP2", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G27", "map_id": "Q55G27", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UJ2", "map_id": "Q54UJ2", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXH8", "map_id": "Q1ZXH8", "name": "gxcDD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279733", "map_id": "DDB_G0279733", "name": "gxcDD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HN1", "map_id": "Q86HN1", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BV5", "map_id": "Q54BV5", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S15", "map_id": "Q54S15", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DW4", "map_id": "Q54DW4", "name": "racGAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291978", "map_id": "DDB_G0291978", "name": "racGAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA7", "map_id": "Q54XA7", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EI2", "map_id": "Q55EI2", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G61", "map_id": "Q55G61", "name": "gxcGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268354", "map_id": "DDB_G0268354", "name": "gxcGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZX99", "map_id": "Q1ZX99", "name": "gxcZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293928", "map_id": "DDB_G0293928", "name": "gxcZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX2", "map_id": "Q54VX2", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K95", "map_id": "Q86K95", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P81", "map_id": "Q54P81", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SG9", "map_id": "Q54SG9", "name": "TIAM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282475", "map_id": "DDB_G0282475", "name": "TIAM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YP1", "map_id": "Q54YP1", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BY9", "map_id": "Q54BY9", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T65", "map_id": "Q54T65", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CA8", "map_id": "Q54CA8", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554I8", "map_id": "Q554I8", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DL8", "map_id": "Q55DL8", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F88", "map_id": "Q54F88", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723417", "map_id": "none", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723414", "map_id": "none", "name": "CDC42 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86B03", "map_id": "Q86B03", "name": "ARHGAP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276833", "map_id": "DDB_G0276833", "name": "ARHGAP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BF1", "map_id": "Q54BF1", "name": "gacE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293654", "map_id": "DDB_G0293654", "name": "gacE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XE8", "map_id": "Q54XE8", "name": "gacP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279009", "map_id": "DDB_G0279009", "name": "gacP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E35", "map_id": "Q54E35", "name": "gacEE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291840", "map_id": "DDB_G0291840", "name": "gacEE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BP9", "map_id": "Q54BP9", "name": "gacV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293510", "map_id": "DDB_G0293510", "name": "gacV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553X3", "map_id": "Q553X3", "name": "gacI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275185", "map_id": "DDB_G0275185", "name": "gacI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG5", "map_id": "Q54PG5", "name": "gacC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284571", "map_id": "DDB_G0284571", "name": "gacC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV3", "map_id": "Q54MV3", "name": "gacJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285641", "map_id": "DDB_G0285641", "name": "gacJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FG5", "map_id": "Q54FG5", "name": "gacJJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290873", "map_id": "DDB_G0290873", "name": "gacJJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE1", "map_id": "Q1ZXE1", "name": "gacM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287895", "map_id": "DDB_G0287895", "name": "gacM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I31", "map_id": "Q86I31", "name": "gacFF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275085", "map_id": "DDB_G0275085", "name": "gacFF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SL6", "map_id": "Q54SL6", "name": "gacQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282395", "map_id": "DDB_G0282395", "name": "gacQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IG9", "map_id": "Q86IG9", "name": "gacH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272694", "map_id": "DDB_G0272694", "name": "gacH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709853", "map_id": "none", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709849", "map_id": "none", "name": "XRCC5:XRCC6:DNA DSBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MA9", "map_id": "Q54MA9", "name": "ku70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286069", "map_id": "DDB_G0286069", "name": "ku70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LY5", "map_id": "Q54LY5", "name": "ku80", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286303", "map_id": "DDB_G0286303", "name": "ku80", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709820", "map_id": "Q54UC0", "name": "dnapkcs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281167", "map_id": "DDB_G0281167", "name": "dnapkcs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709824", "map_id": "none", "name": "PRKDC:XRCC5:XRCC6:DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UC0", "map_id": "Q54UC0", "name": "dnapkcs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709818", "map_id": "none", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10706016", "map_id": "none", "name": "XRCC4:LIG4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54YJ7", "map_id": "Q54YJ7", "name": "xrcc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278203", "map_id": "DDB_G0278203", "name": "xrcc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CR9", "map_id": "Q54CR9", "name": "lig4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292760", "map_id": "DDB_G0292760", "name": "lig4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10706025", "map_id": "Q1ZXF2", "name": "polB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284713", "map_id": "DDB_G0284713", "name": "polB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10706023", "map_id": "none", "name": "NHEJ1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P54", "map_id": "Q54P54", "name": "NHEJ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284785", "map_id": "DDB_G0284785", "name": "NHEJ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709816", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10706029", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXF2", "map_id": "Q1ZXF2", "name": "polB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709827", "map_id": "none", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705998", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10706007", "map_id": "none", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10706000", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10706004", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709842", "map_id": "none", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709792", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709839", "map_id": "none", "name": "(TDP1,TDP2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q556S0", "map_id": "Q556S0", "name": "TDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273125", "map_id": "DDB_G0273125", "name": "TDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DD6", "map_id": "Q55DD6", "name": "TDP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269692", "map_id": "DDB_G0269692", "name": "TDP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10706034", "map_id": "none", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10706031", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709795", "map_id": "none", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10695511", "map_id": "none", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10695509", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10683624", "map_id": "none", "name": "CDC42:GTP, RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10685605", "map_id": "Q55GV3", "name": "phospho-pakC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683629", "map_id": "Q55GV3", "name": "pakC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10695587", "map_id": "none", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693765", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10695583", "map_id": "none", "name": "WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96623", "map_id": "O96623", "name": "arcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282813", "map_id": "DDB_G0282813", "name": "arcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96624", "map_id": "O96624", "name": "arcC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292804", "map_id": "DDB_G0292804", "name": "arcC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6UK63", "map_id": "Q6UK63", "name": "pirA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287855", "map_id": "DDB_G0287855", "name": "pirA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FT9", "map_id": "Q55FT9", "name": "phospho-abiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267956", "map_id": "DDB_G0267956", "name": "phospho-abiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96622", "map_id": "O96622", "name": "arcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277825", "map_id": "DDB_G0277825", "name": "arcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X65", "map_id": "Q54X65", "name": "brk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279175", "map_id": "DDB_G0279175", "name": "brk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96626", "map_id": "O96626", "name": "arcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288319", "map_id": "DDB_G0288319", "name": "arcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NF8", "map_id": "Q54NF8", "name": "scrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285253", "map_id": "DDB_G0285253", "name": "scrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869Q3", "map_id": "Q869Q3", "name": "napA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274519", "map_id": "DDB_G0274519", "name": "napA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96621", "map_id": "O96621", "name": "arpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272106", "map_id": "DDB_G0272106", "name": "arpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42528", "map_id": "P42528", "name": "arpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283755", "map_id": "DDB_G0283755", "name": "arpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96625", "map_id": "O96625", "name": "arcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269102", "map_id": "DDB_G0269102", "name": "arcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10695585", "map_id": "none", "name": "Mother filament:branching complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10696677", "map_id": "none", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10695631", "map_id": "none", "name": "Mother filament:ARP2/3:actin:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10695581", "map_id": "none", "name": "WAVE2, WASP, N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10695513", "map_id": "none", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10695633", "map_id": "none", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680919", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10693810", "map_id": "none", "name": "Mother filament:branching complex:daughter filament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721256", "map_id": "none", "name": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676998", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288373", "map_id": "DDB_G0288373", "name": "efbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721248", "map_id": "P15112", "name": "efbA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721253", "map_id": "Q86JB0", "name": "EEF2KMT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277003", "map_id": "DDB_G0277003", "name": "EEF2KMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721245", "map_id": "none", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672551", "map_id": "P36415", "name": "hspB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10721237", "map_id": "P36415", "name": "hspB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10721242", "map_id": "Q54IN5", "name": "METTL21A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0288643", "map_id": "DDB_G0288643", "name": "VCPKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721301", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676967", "map_id": "none", "name": "Homologues of EEF1A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P0CT31", "map_id": "P0CT31", "name": "eef1a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269134", "map_id": "DDB_G0269134", "name": "eef1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CT32", "map_id": "P0CT32", "name": "eef1a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269136", "map_id": "DDB_G0269136", "name": "eef1a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721293", "map_id": "none", "name": "Homologues of Me3K318-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721298", "map_id": "Q54Y42", "name": "METTL10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278427", "map_id": "DDB_G0278427", "name": "METTL10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721279", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701959", "map_id": "P90532", "name": "cdcD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288065", "map_id": "DDB_G0288065", "name": "cdcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721267", "map_id": "P90532", "name": "cdcD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721276", "map_id": "none", "name": "Homologues of VCPKMT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UI5", "map_id": "Q54UI5", "name": "VCPKMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IN5", "map_id": "Q54IN5", "name": "VCPKMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721214", "map_id": "none", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673088", "map_id": "P27685", "name": "rps2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721209", "map_id": "P27685", "name": "rps2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721211", "map_id": "Q54EF2", "name": "prmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0291556", "map_id": "DDB_G0291556", "name": "prmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721234", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721226", "map_id": "none", "name": "Homologues of Me3K79-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721231", "map_id": "Q86A24", "name": "N6AMT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272708", "map_id": "DDB_G0272708", "name": "N6AMT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679876", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194644", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194735", "map_id": "CHEBI:63842", "name": "4C4MZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679873", "map_id": "Q55D52", "name": "MSMO1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279611", "map_id": "DDB_G0279611", "name": "CH25H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679891", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_194681", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194688", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194725", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194704", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194668", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10679888", "map_id": "Q55GJ9", "name": "AF308470", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "DDB_G0267448", "map_id": "DDB_G0267448", "name": "AF308470", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679622", "map_id": "none", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679617", "map_id": "none", "name": "FDFT:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54DR1", "map_id": "Q54DR1", "name": "fdfT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292072", "map_id": "DDB_G0292072", "name": "fdfT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679843", "map_id": "none", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193459", "map_id": "CHEBI:27393", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193732", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10679736", "map_id": "none", "name": "HSD17B4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54XZ0", "map_id": "Q54XZ0", "name": "mfeB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277911", "map_id": "DDB_G0277911", "name": "mfeB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725944", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10700356", "map_id": "Q54PN2", "name": "SRD5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284423", "map_id": "DDB_G0284423", "name": "SRD5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718908", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10718905", "map_id": "none", "name": "OSBPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MPQ7", "map_id": "Q8MPQ7", "name": "osbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280053", "map_id": "DDB_G0280053", "name": "osbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR2", "map_id": "Q55CR2", "name": "osbC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269940", "map_id": "DDB_G0269940", "name": "osbC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HL8", "map_id": "Q86HL8", "name": "osbE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274517", "map_id": "DDB_G0274517", "name": "osbE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EF5", "map_id": "Q54EF5", "name": "osbL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291562", "map_id": "DDB_G0291562", "name": "osbL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NM4", "map_id": "Q54NM4", "name": "osbJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285141", "map_id": "DDB_G0285141", "name": "osbJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR3", "map_id": "Q55CR3", "name": "osbB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269938", "map_id": "DDB_G0269938", "name": "osbB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KG4", "map_id": "Q86KG4", "name": "osbD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272498", "map_id": "DDB_G0272498", "name": "osbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QP6", "map_id": "Q54QP6", "name": "osbH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283709", "map_id": "DDB_G0283709", "name": "osbH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ID7", "map_id": "Q54ID7", "name": "osbK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288817", "map_id": "DDB_G0288817", "name": "osbK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HV4", "map_id": "Q86HV4", "name": "osbF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276427", "map_id": "DDB_G0276427", "name": "osbF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679883", "map_id": "none", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194723", "map_id": "CHEBI:63841", "name": "4MZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194657", "map_id": "CHEBI:63844", "name": "4CZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10679552", "map_id": "none", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191269", "map_id": "CHEBI:15440", "name": "SQNE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191309", "map_id": "CHEBI:15441", "name": "SQOX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679549", "map_id": "none", "name": "SQLE:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54BK7", "map_id": "Q54BK7", "name": "SQLE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293584", "map_id": "DDB_G0293584", "name": "SQLE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679863", "map_id": "none", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196366", "map_id": "CHEBI:63843", "name": "pregn-5-ene-3,20-dione-17-ol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193092", "map_id": "CHEBI:17252", "name": "17aHPROG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679767", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54TU9", "map_id": "Q54TU9", "name": "HSD3B7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281487", "map_id": "DDB_G0281487", "name": "HSD3B7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XR1", "map_id": "Q54XR1", "name": "HSD3B7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679729", "map_id": "none", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192114", "map_id": "CHEBI:17500", "name": "7 alpha-hydroxycholesterol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_192136", "map_id": "CHEBI:17899", "name": "4CHOL7aOLONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679726", "map_id": "none", "name": "Homologues of HSD3B7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10679632", "map_id": "none", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191403", "map_id": "CHEBI:15899", "name": "MVA5PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679629", "map_id": "none", "name": "MVD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YQ9", "map_id": "Q54YQ9", "name": "mvd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278607", "map_id": "DDB_G0278607", "name": "mvd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679834", "map_id": "none", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_193416", "map_id": "none", "name": "bile salts", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193479", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:9407", "map_id": "CHEBI:9407", "name": "CHEBI:9407", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679831", "map_id": "none", "name": "Homologues of ABCB11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8T9W1", "map_id": "Q8T9W1", "name": "tagD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286123", "map_id": "DDB_G0286123", "name": "tagD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54683", "map_id": "P54683", "name": "tagB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286119", "map_id": "DDB_G0286119", "name": "tagB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RU1", "map_id": "Q54RU1", "name": "abcB6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282931", "map_id": "DDB_G0282931", "name": "abcB6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23868", "map_id": "Q23868", "name": "tagC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286121", "map_id": "DDB_G0286121", "name": "tagC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W24", "map_id": "Q54W24", "name": "abcB4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279915", "map_id": "DDB_G0279915", "name": "abcB4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BU4", "map_id": "Q54BU4", "name": "abcB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293416", "map_id": "DDB_G0293416", "name": "abcB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GTN7", "map_id": "Q9GTN7", "name": "tagA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293002", "map_id": "DDB_G0293002", "name": "tagA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BT3", "map_id": "Q54BT3", "name": "abcB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293438", "map_id": "DDB_G0293438", "name": "abcB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T9W4", "map_id": "Q8T9W4", "name": "abcB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291714", "map_id": "DDB_G0291714", "name": "abcB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714962", "map_id": "none", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807048", "map_id": "CHEBI:16608", "name": "ZYMSTNL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6807054", "map_id": "CHEBI:17168", "name": "LTHSOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10679836", "map_id": "none", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193442", "map_id": "CHEBI:15494", "name": "25(S) DHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10679746", "map_id": "none", "name": "ACOX2:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54GQ6", "map_id": "Q54GQ6", "name": "acox1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289993", "map_id": "DDB_G0289993", "name": "acox1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679590", "map_id": "none", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194634", "map_id": "CHEBI:16521", "name": "LAN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679587", "map_id": "Q55D85", "name": "cas1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269226", "map_id": "DDB_G0269226", "name": "cas1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679881", "map_id": "none", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194667", "map_id": "CHEBI:50593", "name": "dh4MZYMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679878", "map_id": "Q54TU9", "name": "NSDHL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10679839", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193422", "map_id": "CHEBI:52050", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192339", "map_id": "CHEBI:27379", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10679600", "map_id": "none", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191296", "map_id": "CHEBI:17436", "name": "MVA5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679597", "map_id": "none", "name": "MVK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AG7", "map_id": "Q86AG7", "name": "mvk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272018", "map_id": "DDB_G0272018", "name": "mvk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679620", "map_id": "none", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10679749", "map_id": "none", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192316", "map_id": "CHEBI:37643", "name": "25(S) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192342", "map_id": "CHEBI:27505", "name": "THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10679714", "map_id": "none", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192148", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679711", "map_id": "none", "name": "CH25H (Fe2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55D54", "map_id": "Q55D54", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D52", "map_id": "Q55D52", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WK0", "map_id": "Q54WK0", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681907", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10681904", "map_id": "Q1ZXF5", "name": "cyp508A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284535", "map_id": "DDB_G0284535", "name": "cyp508A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679564", "map_id": "none", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679561", "map_id": "none", "name": "holo-FDPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NH03", "map_id": "Q9NH03", "name": "fps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278735", "map_id": "DDB_G0278735", "name": "fps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679913", "map_id": "none", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194661", "map_id": "CHEBI:52386", "name": "ZYMONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10679784", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193079", "map_id": "CHEBI:16422", "name": "ANDST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679582", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191374", "map_id": "CHEBI:43074", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679579", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P34135", "map_id": "P34135", "name": "hmgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269142", "map_id": "DDB_G0269142", "name": "hmgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686933", "map_id": "none", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686930", "map_id": "none", "name": "HSD17B1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WA9", "map_id": "Q54WA9", "name": "HSD17B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279783", "map_id": "DDB_G0279783", "name": "HSD17B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679739", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10701893", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10701890", "map_id": "Q54GD9", "name": "arv1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290221", "map_id": "DDB_G0290221", "name": "arv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679567", "map_id": "none", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679871", "map_id": "none", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_194156", "map_id": "none", "name": "bile salts and acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16755", "map_id": "CHEBI:16755", "name": "CHEBI:16755", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16359", "map_id": "CHEBI:16359", "name": "CHEBI:16359", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_192483", "map_id": "none", "name": "bile salts and acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10679868", "map_id": "Q54NL1", "name": "abcC9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285165", "map_id": "DDB_G0285165", "name": "abcC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679770", "map_id": "none", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196344", "map_id": "CHEBI:63837", "name": "pregn-5-ene-3,20-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193055", "map_id": "CHEBI:17026", "name": "P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10726092", "map_id": "none", "name": "GGPS1 hexamer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10726089", "map_id": "none", "name": "holo-GGPS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54BK1", "map_id": "Q54BK1", "name": "ggps1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293588", "map_id": "DDB_G0293588", "name": "ggps1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679782", "map_id": "none", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679779", "map_id": "none", "name": "HSD17B3-like Proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10679928", "map_id": "none", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193124", "map_id": "CHEBI:28750", "name": "17aHPREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679841", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193403", "map_id": "CHEBI:28533", "name": "3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10726095", "map_id": "none", "name": "GGPS1 hexamer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10679861", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192194", "map_id": "CHEBI:18431", "name": "Cholest-5-ene-3beta,7alpha,27-triol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193835", "map_id": "CHEBI:48825", "name": "4CHOL7a,27DONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10679911", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194633", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10679908", "map_id": "none", "name": "Homologues of TM7SF2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54PP1", "map_id": "Q54PP1", "name": "erg24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284407", "map_id": "DDB_G0284407", "name": "erg24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GJ9", "map_id": "Q55GJ9", "name": "AF308470", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679572", "map_id": "none", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191293", "map_id": "CHEBI:57286", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679569", "map_id": "Q86HL5", "name": "hgsB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274871", "map_id": "DDB_G0274871", "name": "hgsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679610", "map_id": "none", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679607", "map_id": "none", "name": "IDI1 or 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NH02", "map_id": "Q9NH02", "name": "ipi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290011", "map_id": "DDB_G0290011", "name": "ipi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679899", "map_id": "none", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679896", "map_id": "Q1ZXH9", "name": "cyp51", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279403", "map_id": "DDB_G0279403", "name": "cyp51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722153", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10722150", "map_id": "Q54UH9", "name": "PLPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0281069", "map_id": "DDB_G0281069", "name": "PLPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679926", "map_id": "none", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679859", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192189", "map_id": "CHEBI:37640", "name": "CHOL7a,24(S)DIOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193724", "map_id": "CHEBI:63838", "name": "4CHOL7a,24(S)DONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10673670", "map_id": "none", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673388", "map_id": "none", "name": "eIF2:GDP: eIF2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54FQ8", "map_id": "Q54FQ8", "name": "eif2b3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290693", "map_id": "DDB_G0290693", "name": "eif2b3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EY2", "map_id": "Q54EY2", "name": "eif2b2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291271", "map_id": "DDB_G0291271", "name": "eif2b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RF3", "map_id": "Q54RF3", "name": "eif2b5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283163", "map_id": "DDB_G0283163", "name": "eif2b5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XD8", "map_id": "Q54XD8", "name": "eif2s3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278967", "map_id": "DDB_G0278967", "name": "eif2s3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T27", "map_id": "Q54T27", "name": "eif2s2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282035", "map_id": "DDB_G0282035", "name": "eif2s2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FM3", "map_id": "Q54FM3", "name": "eif2b4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290759", "map_id": "DDB_G0290759", "name": "eif2b4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I81", "map_id": "Q54I81", "name": "eif2b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288961", "map_id": "DDB_G0288961", "name": "eif2b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N9", "map_id": "Q869N9", "name": "phospho-eif2s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271862", "map_id": "DDB_G0271862", "name": "phospho-eif2s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673296", "map_id": "none", "name": "eIF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673386", "map_id": "none", "name": "eIF2B subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10673390", "map_id": "none", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673338", "map_id": "none", "name": "eIF2:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10712164", "map_id": "none", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10712158", "map_id": "Q54BC9", "name": "dyrk2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293750", "map_id": "DDB_G0293750", "name": "phospho-dyrk2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712162", "map_id": "Q54BC9", "name": "phospho-dyrk2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10682355", "map_id": "Q553E9", "name": "phospho-smg1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10714907", "map_id": "none", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10714903", "map_id": "none", "name": "Casein kinase II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676372", "map_id": "none", "name": "FACT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54S43", "map_id": "Q54S43", "name": "spt16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282677", "map_id": "DDB_G0282677", "name": "spt16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G78", "map_id": "Q54G78", "name": "ssrp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290331", "map_id": "DDB_G0290331", "name": "ssrp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714905", "map_id": "none", "name": "CK2:FACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700599", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698368", "map_id": "none", "name": "SUMO2:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54SX2", "map_id": "Q54SX2", "name": "UBE2I-G92-SUMO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282161", "map_id": "DDB_G0282161", "name": "UBE2I-G92-SUMO3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700571", "map_id": "Q55FI4", "name": "nop58", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700596", "map_id": "Q55FI4", "name": "nop58", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10700587", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700585", "map_id": "none", "name": "2SUMO1:NOP58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676662", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10676659", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10676758", "map_id": "none", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10676755", "map_id": "none", "name": "P2X purinoreceptors:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10692427", "map_id": "none", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605601", "map_id": "CHEBI:17950", "name": "LacCer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605592", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10692508", "map_id": "none", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429776", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1610735", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10692505", "map_id": "Q54MJ8", "name": "ENPP7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10692400", "map_id": "none", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605608", "map_id": "CHEBI:61360", "name": "Globoside", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605716", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605658", "map_id": "CHEBI:28037", "name": "GalNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10692397", "map_id": "none", "name": "HEXA,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54K55", "map_id": "Q54K55", "name": "hexb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287597", "map_id": "DDB_G0287597", "name": "hexb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SC9", "map_id": "Q54SC9", "name": "hexa2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282539", "map_id": "DDB_G0282539", "name": "hexa2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13723", "map_id": "P13723", "name": "hexa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287033", "map_id": "DDB_G0287033", "name": "hexa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MU9", "map_id": "Q54MU9", "name": "HEXA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285647", "map_id": "DDB_G0285647", "name": "HEXA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K56", "map_id": "Q54K56", "name": "hexb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287659", "map_id": "DDB_G0287659", "name": "hexb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693818", "map_id": "none", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861782", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10693815", "map_id": "Q54D71", "name": "GBA2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0292446", "map_id": "DDB_G0292446", "name": "GBA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692360", "map_id": "none", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605677", "map_id": "CHEBI:61048", "name": "GM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_1605610", "map_id": "CHEBI:51013", "name": "GM2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10692425", "map_id": "none", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605713", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605750", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10692422", "map_id": "Q54C16", "name": "sgmB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0293210", "map_id": "DDB_G0293210", "name": "sgmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692437", "map_id": "none", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10692434", "map_id": "none", "name": "ASAH2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54BK2", "map_id": "Q54BK2", "name": "dcd2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293538", "map_id": "DDB_G0293538", "name": "dcd2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692417", "map_id": "none", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10692414", "map_id": "none", "name": "GLA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q55B10", "map_id": "Q55B10", "name": "melA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271490", "map_id": "DDB_G0271490", "name": "melA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EG4", "map_id": "Q54EG4", "name": "GLA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291524", "map_id": "DDB_G0291524", "name": "GLA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702402", "map_id": "none", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684166", "map_id": "none", "name": "Homologues of NOS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684155", "map_id": "none", "name": "Homologues of ATP2B4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702400", "map_id": "none", "name": "ATP2B4:NOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10688485", "map_id": "none", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10688478", "map_id": "none", "name": "TRAF6:p-IRAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10688480", "map_id": "none", "name": "p-IRAK2:oligo-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10688006", "map_id": "none", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687994", "map_id": "none", "name": "TRAF6:p-IRAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10687996", "map_id": "none", "name": "p-IRAK2:oligo-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10688483", "map_id": "none", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10678168", "map_id": "none", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10678162", "map_id": "none", "name": "Homologues of TLR10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54BH0", "map_id": "Q54BH0", "name": "TLR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293628", "map_id": "DDB_G0293628", "name": "TLR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K36", "map_id": "Q54K36", "name": "TLR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_168948", "map_id": "none", "name": "Ligand recognized by TLR10", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10678166", "map_id": "none", "name": "TLR10 homodimer bound to ligand", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10719248", "map_id": "none", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2186967", "map_id": "CHEBI:60156", "name": "oxidized phospholipids", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677632", "map_id": "none", "name": "Homologues of LBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54JE8", "map_id": "Q54JE8", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288097", "map_id": "DDB_G0288097", "name": "LBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE7", "map_id": "Q54JE7", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BA2", "map_id": "Q55BA2", "name": "BPI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271242", "map_id": "DDB_G0271242", "name": "BPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10719246", "map_id": "none", "name": "LBP:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10688009", "map_id": "none", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10688001", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10677638", "map_id": "none", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10677634", "map_id": "none", "name": "LBP:bacterial LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_6803081", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677636", "map_id": "Q55BA2", "name": "BPI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10714923", "map_id": "none", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10682340", "map_id": "Q55C24", "name": "nhp6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0270260", "map_id": "DDB_G0270260", "name": "nhp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714865", "map_id": "Q55C24", "name": "nhp6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10688004", "map_id": "none", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10714873", "map_id": "none", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10714871", "map_id": "none", "name": "HC23,45-HMGB1:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q55C24", "map_id": "Q55C24", "name": "nhp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714869", "map_id": "none", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_181015", "map_id": "CHEBI:28640", "name": "Lipoteichoic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10714867", "map_id": "none", "name": "HC23,45-HMGB1:LTA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10704731", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10704728", "map_id": "Q9GPS6", "name": "pcmA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280979", "map_id": "DDB_G0280979", "name": "pcmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726173", "map_id": "none", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9751015", "map_id": "LigandDisplayForward?ligandId=7226", "name": "6MP", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9748998", "map_id": "LigandDisplayForward?ligandId=7226", "name": "6MP", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10726170", "map_id": "none", "name": "SLC29A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TT3", "map_id": "Q54TT3", "name": "SLC29A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281515", "map_id": "DDB_G0281515", "name": "SLC29A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R17", "map_id": "Q54R17", "name": "SLC29A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283439", "map_id": "DDB_G0283439", "name": "SLC29A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TT2", "map_id": "Q54TT2", "name": "SLC29A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726136", "map_id": "none", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9748960", "map_id": "CHEBI:180687", "name": "6TGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748947", "map_id": "CHEBI:180688", "name": "6TGTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686491", "map_id": "none", "name": "nucleoside diphosphate kinase 1A:5B heterohexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34093", "map_id": "P34093", "name": "ndkM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279911", "map_id": "DDB_G0279911", "name": "ndkM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726125", "map_id": "none", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748959", "map_id": "CHEBI:180685", "name": "6TXMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748970", "map_id": "CHEBI:180686", "name": "6TGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10726122", "map_id": "none", "name": "GMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P32073", "map_id": "P32073", "name": "guaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281551", "map_id": "DDB_G0281551", "name": "guaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726134", "map_id": "none", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29450", "map_id": "CHEBI:57925", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748994", "map_id": "LigandDisplayForward?ligandId=7120", "name": "AZA", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9748975", "map_id": "CHEBI:180931", "name": "GS-nitroimidazole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10678993", "map_id": "none", "name": "GSTA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VI4", "map_id": "Q54VI4", "name": "gsta3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280317", "map_id": "DDB_G0280317", "name": "gsta3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FF3", "map_id": "Q55FF3", "name": "gsta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268138", "map_id": "DDB_G0268138", "name": "gsta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AU1", "map_id": "Q86AU1", "name": "gsta4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274263", "map_id": "DDB_G0274263", "name": "gsta4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QV7", "map_id": "Q54QV7", "name": "gsta5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283575", "map_id": "DDB_G0283575", "name": "gsta5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556P3", "map_id": "Q556P3", "name": "GSTP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273153", "map_id": "DDB_G0273153", "name": "GSTP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556G3", "map_id": "Q556G3", "name": "gsta2-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272632", "map_id": "DDB_G0272632", "name": "gsta2-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726163", "map_id": "none", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9750557", "map_id": "none", "name": "ABCC5 TPMP substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9748992", "map_id": "CHEBI:180684", "name": "6TIMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "pubchem.compound:3037883", "map_id": "pubchem.compound:3037883", "name": "pubchem.compound:3037883", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9750602", "map_id": "none", "name": "ABCC5 TPMP substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:80613", "map_id": "CHEBI:80613", "name": "CHEBI:80613", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:80612", "map_id": "CHEBI:80612", "name": "CHEBI:80612", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:2332", "map_id": "CHEBI:2332", "name": "CHEBI:2332", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10691230", "map_id": "none", "name": "Homologues of ABCC5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54P13", "map_id": "Q54P13", "name": "abcC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284867", "map_id": "DDB_G0284867", "name": "abcC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ST87", "map_id": "Q8ST87", "name": "abcC10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280977", "map_id": "DDB_G0280977", "name": "abcC10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U44", "map_id": "Q54U44", "name": "abcC12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280973", "map_id": "DDB_G0280973", "name": "abcC12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LE6", "map_id": "Q54LE6", "name": "abcC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286559", "map_id": "DDB_G0286559", "name": "abcC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JR2", "map_id": "Q54JR2", "name": "abcC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287691", "map_id": "DDB_G0287691", "name": "abcC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726129", "map_id": "none", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9749033", "map_id": "CHEBI:180690", "name": "6TdGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9749032", "map_id": "CHEBI:180691", "name": "6TdGTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10726118", "map_id": "none", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674001", "map_id": "none", "name": "IMPDH1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QQ0", "map_id": "Q54QQ0", "name": "impdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283701", "map_id": "DDB_G0283701", "name": "impdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726127", "map_id": "none", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9749031", "map_id": "CHEBI:180689", "name": "6TdGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673983", "map_id": "Q54XF2", "name": "guk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279001", "map_id": "DDB_G0279001", "name": "guk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726131", "map_id": "none", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9748978", "map_id": "CHEBI:80608", "name": "6TU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674335", "map_id": "none", "name": "XDH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FB7", "map_id": "Q54FB7", "name": "xdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291047", "map_id": "DDB_G0291047", "name": "xdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726120", "map_id": "none", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10678801", "map_id": "none", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678647", "map_id": "none", "name": "phospho-Cdh1:phospho-APC/C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10678645", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10678597", "map_id": "Q54KM3", "name": "phospho-cdh1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10678652", "map_id": "none", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678649", "map_id": "none", "name": "multiubiquitinated Cdh1 associated with APC/C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678780", "map_id": "none", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678775", "map_id": "none", "name": "Cdc2:Cyclin A:MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556Y9", "map_id": "Q556Y9", "name": "mad2l1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273201", "map_id": "DDB_G0273201", "name": "mad2l1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CV5", "map_id": "Q54CV5", "name": "bub1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292676", "map_id": "DDB_G0292676", "name": "bub1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM1", "map_id": "Q54DM1", "name": "bub3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292134", "map_id": "DDB_G0292134", "name": "bub3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678777", "map_id": "none", "name": "multiubiquitinated Cyclin A associated with MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10676850", "map_id": "none", "name": "MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678754", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10678741", "map_id": "none", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678738", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678784", "map_id": "none", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678782", "map_id": "none", "name": "multiubiquitinated cell cycle protein:APC/C:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WX4", "map_id": "Q54WX4", "name": "aurK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279343", "map_id": "DDB_G0279343", "name": "aurK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679249", "map_id": "none", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10679167", "map_id": "none", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679160", "map_id": "none", "name": "Nek2A:MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BN8", "map_id": "Q55BN8", "name": "nek2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270814", "map_id": "DDB_G0270814", "name": "nek2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679164", "map_id": "none", "name": "Multiubiquitinated Nek2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10676858", "map_id": "none", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676836", "map_id": "Q54DM1", "name": "bub3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676831", "map_id": "Q54CV5", "name": "bub1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676846", "map_id": "Q556Y9", "name": "mad2l1-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676848", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2*:CDC20 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679169", "map_id": "none", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10678858", "map_id": "none", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678844", "map_id": "none", "name": "SCF-associated multiubiquitinated Emi1complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678856", "map_id": "none", "name": "Cdc20/Cdh1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678838", "map_id": "none", "name": "BTRC:CUL1:SKP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678769", "map_id": "none", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678765", "map_id": "none", "name": "(APC/C:Cdh1)-targeted cell cycle proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678767", "map_id": "none", "name": "cell cycle proteins:phospho-APC/C:Cdh1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678852", "map_id": "none", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10678854", "map_id": "none", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678809", "map_id": "none", "name": "CDC20:pAPC/C:K11polyUb-PTTG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679162", "map_id": "none", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679158", "map_id": "Q55BN8", "name": "nek2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10676852", "map_id": "none", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10678862", "map_id": "none", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678821", "map_id": "none", "name": "Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P42524", "map_id": "P42524", "name": "cycB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275493", "map_id": "DDB_G0275493", "name": "cycB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678823", "map_id": "none", "name": "multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679245", "map_id": "none", "name": "APC/C:Cdh1-mediated degradation of Skp2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679243", "map_id": "none", "name": "PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678812", "map_id": "none", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678805", "map_id": "none", "name": "CDC20:p-APC/C:PTTG1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10676856", "map_id": "none", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676854", "map_id": "none", "name": "MAD2*CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678868", "map_id": "none", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678866", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2* complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725854", "map_id": "none", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10725851", "map_id": "none", "name": "RB1:SKP2:APC/C:Cdh1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678795", "map_id": "none", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10678847", "map_id": "none", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678842", "map_id": "none", "name": "SCF-beta-TrCP:phospho-Emi1 complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693242", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_10692970", "map_id": "none", "name": "MTM1,MTMR2,MTMR4,MTMR7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691994", "map_id": "none", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691991", "map_id": "none", "name": "PLD1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54Z25", "map_id": "Q54Z25", "name": "pldC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277949", "map_id": "DDB_G0277949", "name": "pldC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UK0", "map_id": "Q54UK0", "name": "pldA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281031", "map_id": "DDB_G0281031", "name": "pldA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q49", "map_id": "Q54Q49", "name": "PLD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284155", "map_id": "DDB_G0284155", "name": "PLD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WR4", "map_id": "Q54WR4", "name": "pldB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279483", "map_id": "DDB_G0279483", "name": "pldB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691844", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691841", "map_id": "none", "name": "CEPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10691704", "map_id": "none", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691677", "map_id": "none", "name": "PLA2(8)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10716710", "map_id": "none", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2239407", "map_id": "CHEBI:60479", "name": "lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_6814794", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10716707", "map_id": "Q54MJ8", "name": "ENPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10691923", "map_id": "none", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691920", "map_id": "none", "name": "PCYT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54GD2", "map_id": "Q54GD2", "name": "PCYT1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290229", "map_id": "DDB_G0290229", "name": "PCYT1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691709", "map_id": "none", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10691773", "map_id": "none", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691770", "map_id": "none", "name": "PLA2(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693140", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10693000", "map_id": "none", "name": "SYNJs,OCRL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D97", "map_id": "Q54D97", "name": "Dd5P3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292392", "map_id": "DDB_G0292392", "name": "Dd5P3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7P3", "map_id": "Q8I7P3", "name": "Dd5P4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267462", "map_id": "DDB_G0267462", "name": "Dd5P4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710251", "map_id": "none", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694502", "map_id": "CHEBI:64483", "name": "LPC(14:0)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5694457", "map_id": "CHEBI:11230", "name": "1AGPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10710248", "map_id": "none", "name": "Homologues of ABHD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55C73", "map_id": "Q55C73", "name": "ABHD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270192", "map_id": "DDB_G0270192", "name": "ABHD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H38", "map_id": "Q54H38", "name": "abhd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289723", "map_id": "DDB_G0289723", "name": "abhd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693123", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10693120", "map_id": "none", "name": "PIK3C2A/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54673", "map_id": "P54673", "name": "pikA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278727", "map_id": "DDB_G0278727", "name": "pikA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54675", "map_id": "P54675", "name": "pikC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275011", "map_id": "DDB_G0275011", "name": "pikC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S78", "map_id": "Q54S78", "name": "PIK3C2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282625", "map_id": "DDB_G0282625", "name": "PIK3C2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54674", "map_id": "P54674", "name": "pikB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283081", "map_id": "DDB_G0283081", "name": "pikB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX5", "map_id": "Q55FX5", "name": "PIK3C2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693332", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806230", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10693329", "map_id": "none", "name": "TPTE2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q553B4", "map_id": "Q553B4", "name": "phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292920", "map_id": "DDB_G0292920", "name": "phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JL7", "map_id": "Q54JL7", "name": "phospho-cnrN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287969", "map_id": "DDB_G0287969", "name": "phospho-cnrN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T9S7", "map_id": "Q8T9S7", "name": "phospho-pteN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286557", "map_id": "DDB_G0286557", "name": "phospho-pteN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MG8", "map_id": "Q54MG8", "name": "phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CH3", "map_id": "Q54CH3", "name": "phospho-PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693135", "map_id": "none", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_202247", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10693132", "map_id": "none", "name": "INPP5(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54W40", "map_id": "Q54W40", "name": "INPP5J", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279927", "map_id": "DDB_G0279927", "name": "INPP5J", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691817", "map_id": "none", "name": "PG is hydrolyzed to 2-acyl LPG by PLA2[14]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691814", "map_id": "none", "name": "PLA2(14)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691802", "map_id": "none", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10691812", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691663", "map_id": "none", "name": "PLA2(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691805", "map_id": "none", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10691737", "map_id": "Q54DX7", "name": "taz", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0291922", "map_id": "DDB_G0291922", "name": "taz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691683", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691652", "map_id": "Q54XX2", "name": "MBOAT7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10691907", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10691904", "map_id": "none", "name": "CHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693310", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10692983", "map_id": "Q54ZN9", "name": "PI4KA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277537", "map_id": "DDB_G0277537", "name": "PI4KA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693137", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10693277", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10693274", "map_id": "Q55AW9", "name": "sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0271630", "map_id": "DDB_G0271630", "name": "sac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717024", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8849959", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_8849958", "map_id": "none", "name": "PI5P, PI3P, PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10717021", "map_id": "none", "name": "Homologues of INPP5F", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q54FY6", "map_id": "Q54FY6", "name": "INPP5F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290653", "map_id": "DDB_G0290653", "name": "INPP5F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HL0", "map_id": "Q86HL0", "name": "INPP5F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AW9", "map_id": "Q55AW9", "name": "sac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716932", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10716927", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10691872", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524057", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10691869", "map_id": "none", "name": "CHPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10691789", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10693250", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10693247", "map_id": "none", "name": "MTM1,MTMR2,MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710279", "map_id": "none", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694568", "map_id": "CHEBI:61232", "name": "NAPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694580", "map_id": "CHEBI:52571", "name": "GPAEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694567", "map_id": "CHEBI:22221", "name": "acyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10710276", "map_id": "none", "name": "Homologues of ABHD4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54QE7", "map_id": "Q54QE7", "name": "ABHD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291476", "map_id": "DDB_G0291476", "name": "ABHD4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EK1", "map_id": "Q54EK1", "name": "ABHD4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691810", "map_id": "none", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691807", "map_id": "none", "name": "PLA2(10)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691822", "map_id": "none", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691819", "map_id": "none", "name": "PLA2(13)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674942", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674939", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54EU4", "map_id": "Q54EU4", "name": "AGPAT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IG1", "map_id": "Q54IG1", "name": "AGPAT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554U0", "map_id": "Q554U0", "name": "AGPAT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274969", "map_id": "DDB_G0274969", "name": "AGPAT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IT8", "map_id": "Q54IT8", "name": "AGPAT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288523", "map_id": "DDB_G0288523", "name": "AGPAT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691795", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691755", "map_id": "none", "name": "Homologues of PNPLA8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10691697", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691694", "map_id": "none", "name": "LPEAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10691999", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691996", "map_id": "Q1ZXJ3", "name": "pssA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0278159", "map_id": "DDB_G0278159", "name": "pssA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10715867", "map_id": "none", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693218", "map_id": "none", "name": "Homologues of MTMR6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715851", "map_id": "none", "name": "Homologues of MTMR9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715865", "map_id": "none", "name": "MTMR6:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693285", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10692026", "map_id": "none", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10691932", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9NCL8", "map_id": "Q9NCL8", "name": "pitA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290069", "map_id": "DDB_G0290069", "name": "pitA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10692024", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10691650", "map_id": "none", "name": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524023", "map_id": "CHEBI:16929", "name": "GPETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693112", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10693109", "map_id": "none", "name": "PIK3C2A/G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691800", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691797", "map_id": "none", "name": "DGAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BH9", "map_id": "Q55BH9", "name": "dgat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271342", "map_id": "DDB_G0271342", "name": "dgat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC1", "map_id": "Q54GC1", "name": "dgat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693081", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10693078", "map_id": "none", "name": "ARF1/3:GTP:PI4KB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54LR9", "map_id": "Q54LR9", "name": "PI4KB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286479", "map_id": "DDB_G0286479", "name": "PI4KB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691743", "map_id": "none", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10691957", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_110577", "map_id": "CHEBI:37563", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524101", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524064", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10691954", "map_id": "Q55D90", "name": "cdsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0269742", "map_id": "DDB_G0269742", "name": "cdsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692991", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10692988", "map_id": "Q8I7P3", "name": "Dd5P4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10691692", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691689", "map_id": "none", "name": "LPSAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10692777", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10691648", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10691645", "map_id": "Q54IT8", "name": "AGPAT5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10691934", "map_id": "none", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10691930", "map_id": "none", "name": "PI:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10686815", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674935", "map_id": "Q554U0", "name": "AGPAT6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10693288", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10692975", "map_id": "none", "name": "PIP5K1A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691685", "map_id": "none", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10715945", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715940", "map_id": "none", "name": "MTMR2:SBF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10693303", "map_id": "none", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10693076", "map_id": "none", "name": "ARF1/3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10693301", "map_id": "Q54LR9", "name": "PI4KB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10691776", "map_id": "none", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524042", "map_id": "CHEBI:17517", "name": "PG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1524085", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524047", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10691717", "map_id": "none", "name": "PLA2G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10691707", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10718992", "map_id": "none", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_33625", "map_id": "CHEBI:18303", "name": "PS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10718989", "map_id": "none", "name": "OSBPL5,8,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RM1", "map_id": "Q54RM1", "name": "osbG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283035", "map_id": "DDB_G0283035", "name": "osbG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691655", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10722413", "map_id": "none", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_189422", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8954419", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_8954401", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10722410", "map_id": "none", "name": "PLD6 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54TK6", "map_id": "Q54TK6", "name": "PLD6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281695", "map_id": "DDB_G0281695", "name": "PLD6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691666", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1524103", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10715912", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10715903", "map_id": "none", "name": "MTM1:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691680", "map_id": "none", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10715948", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10691792", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10710324", "map_id": "none", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_5696069", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696066", "map_id": "none", "name": "MAG,DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_5696026", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696037", "map_id": "none", "name": "LPA,PA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_417891", "map_id": "CHEBI:52288", "name": "LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10710321", "map_id": "none", "name": "AGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q6B516", "map_id": "Q6B516", "name": "sgkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JX1", "map_id": "Q75JX1", "name": "sgkC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272350", "map_id": "DDB_G0272350", "name": "sgkC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KF9", "map_id": "Q86KF9", "name": "sgkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272522", "map_id": "DDB_G0272522", "name": "sgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HN2", "map_id": "Q54HN2", "name": "AGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289343", "map_id": "DDB_G0289343", "name": "AGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692978", "map_id": "none", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10715905", "map_id": "none", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10692890", "map_id": "none", "name": "Homologues of MTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715901", "map_id": "none", "name": "Homologues of MTMR12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721170", "map_id": "none", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8878649", "map_id": "CHEBI:62833", "name": "MYS-LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8934414", "map_id": "CHEBI:75562", "name": "1-MMG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10721167", "map_id": "Q54P71", "name": "ACP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0284755", "map_id": "DDB_G0284755", "name": "ACPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691765", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691762", "map_id": "none", "name": "PLA2(11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710368", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10680333", "map_id": "none", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680330", "map_id": "none", "name": "Homologues of PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691952", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426955", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691949", "map_id": "none", "name": "CDS1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55D90", "map_id": "Q55D90", "name": "cdsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691882", "map_id": "none", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426910", "map_id": "CHEBI:17268", "name": "Ins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691879", "map_id": "none", "name": "CDIPT:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54P27", "map_id": "Q54P27", "name": "CDIPT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284857", "map_id": "DDB_G0284857", "name": "CDIPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685601", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685598", "map_id": "none", "name": "CTL1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54IJ2", "map_id": "Q54IJ2", "name": "SLC44A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288717", "map_id": "DDB_G0288717", "name": "SLC44A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I48", "map_id": "Q54I48", "name": "slc44a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289013", "map_id": "DDB_G0289013", "name": "slc44a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711099", "map_id": "none", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10711096", "map_id": "none", "name": "DDHD1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KP6", "map_id": "Q86KP6", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276935", "map_id": "DDB_G0276935", "name": "PITPNM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EA5", "map_id": "Q54EA5", "name": "SEC23IP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291694", "map_id": "DDB_G0291694", "name": "SEC23IP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DP0", "map_id": "Q55DP0", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DN9", "map_id": "Q55DN9", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691727", "map_id": "none", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1498753", "map_id": "CHEBI:60431", "name": "DLCL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10691724", "map_id": "none", "name": "PLA2G4A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10693335", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10693095", "map_id": "none", "name": "PIK3C2A:Ca2+/Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693308", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693305", "map_id": "none", "name": "SYNJ/INPP5(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693296", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693293", "map_id": "none", "name": "PIP4K2/5K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693282", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10693279", "map_id": "Q55AW9", "name": "sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10693291", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10691965", "map_id": "none", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691962", "map_id": "Q54SD5", "name": "pemtA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282527", "map_id": "DDB_G0282527", "name": "pemtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722158", "map_id": "none", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2173763", "map_id": "CHEBI:60479", "name": "lysoPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8952253", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8954142", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10722155", "map_id": "Q54XE3", "name": "PLA2G15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0279019", "map_id": "DDB_G0279019", "name": "LCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693313", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693225", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691699", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10691732", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10720416", "map_id": "none", "name": "PLEKHA4,(5,6) bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10720412", "map_id": "none", "name": "PLEKHA4,(5,6)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54Z52", "map_id": "Q54Z52", "name": "PLEKHA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277777", "map_id": "DDB_G0277777", "name": "PLEKHA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10720414", "map_id": "none", "name": "PLEKHA4,(5,6):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10693003", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10719120", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719117", "map_id": "none", "name": "PITPNM1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NCL7", "map_id": "Q9NCL7", "name": "pitB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274579", "map_id": "DDB_G0274579", "name": "pitB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D93", "map_id": "Q54D93", "name": "pitD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292426", "map_id": "DDB_G0292426", "name": "pitD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693228", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10691640", "map_id": "none", "name": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10715942", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10692916", "map_id": "none", "name": "Homologues of MTMR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715938", "map_id": "none", "name": "Homologues of SBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10682763", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10682758", "map_id": "none", "name": "Homologues of ACHE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54WD8", "map_id": "Q54WD8", "name": "CES2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291344", "map_id": "DDB_G0291344", "name": "CES2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18142", "map_id": "P18142", "name": "D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283085", "map_id": "DDB_G0283085", "name": "D2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N21", "map_id": "Q54N21", "name": "CES2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21837", "map_id": "P21837", "name": "cryS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285419", "map_id": "DDB_G0285419", "name": "cryS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L18", "map_id": "Q86L18", "name": "CES2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET7", "map_id": "Q54ET7", "name": "CES2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682761", "map_id": "none", "name": "ACHE:ACHEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=8994", "map_id": "LigandDisplayForward?ligandId=8994", "name": "LigandDisplayForward?ligandId=8994", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8993", "map_id": "LigandDisplayForward?ligandId=8993", "name": "LigandDisplayForward?ligandId=8993", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6602", "map_id": "LigandDisplayForward?ligandId=6602", "name": "LigandDisplayForward?ligandId=6602", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6599", "map_id": "LigandDisplayForward?ligandId=6599", "name": "LigandDisplayForward?ligandId=6599", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6687", "map_id": "LigandDisplayForward?ligandId=6687", "name": "LigandDisplayForward?ligandId=6687", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6598", "map_id": "LigandDisplayForward?ligandId=6598", "name": "LigandDisplayForward?ligandId=6598", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6693", "map_id": "LigandDisplayForward?ligandId=6693", "name": "LigandDisplayForward?ligandId=6693", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7597", "map_id": "LigandDisplayForward?ligandId=7597", "name": "LigandDisplayForward?ligandId=7597", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9073", "map_id": "LigandDisplayForward?ligandId=9073", "name": "LigandDisplayForward?ligandId=9073", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9074", "map_id": "LigandDisplayForward?ligandId=9074", "name": "LigandDisplayForward?ligandId=9074", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693239", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693236", "map_id": "none", "name": "PIK3C(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DK0", "map_id": "Q54DK0", "name": "PIK3R6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292252", "map_id": "DDB_G0292252", "name": "PIK3R6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702080", "map_id": "none", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10702076", "map_id": "none", "name": "CPNEs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86K21", "map_id": "Q86K21", "name": "cpnB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272875", "map_id": "DDB_G0272875", "name": "cpnB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY7", "map_id": "Q54FY7", "name": "cpnE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290529", "map_id": "DDB_G0290529", "name": "cpnE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB3", "map_id": "Q1ZXB3", "name": "cpnF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291498", "map_id": "DDB_G0291498", "name": "cpnF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GG1", "map_id": "Q55GG1", "name": "cpnD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267688", "map_id": "DDB_G0267688", "name": "cpnD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P51", "map_id": "Q54P51", "name": "cpnC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284791", "map_id": "DDB_G0284791", "name": "cpnC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_171142", "map_id": "CHEBI:16247", "name": "PL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10702078", "map_id": "none", "name": "CPNEs:PL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10715875", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10715869", "map_id": "none", "name": "MTMR6:MTMR9,MTMR8:MTMR9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10715909", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715907", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693299", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10691942", "map_id": "none", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10691939", "map_id": "Q1ZXJ3", "name": "pssA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10692973", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10691720", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524027", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10715855", "map_id": "none", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715825", "map_id": "Q1ZXD2", "name": "MTMR8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10715853", "map_id": "none", "name": "MTMR8:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10691635", "map_id": "none", "name": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498728", "map_id": "CHEBI:17389", "name": "2-MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500593", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10691632", "map_id": "none", "name": "MGLL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55EQ3", "map_id": "Q55EQ3", "name": "MGLL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269086", "map_id": "DDB_G0269086", "name": "MGLL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721177", "map_id": "none", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8878780", "map_id": "CHEBI:7794", "name": "phosphate monoester", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8878776", "map_id": "CHEBI:30879", "name": "Alcohol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10721174", "map_id": "none", "name": "ALPI:2Ca2+:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54Y02", "map_id": "Q54Y02", "name": "ALPI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278495", "map_id": "DDB_G0278495", "name": "ALPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691702", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10692986", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10692049", "map_id": "none", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10692028", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10693269", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693266", "map_id": "none", "name": "PIK3(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10715872", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10693230", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "reaction_10718631", "map_id": "none", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8865642", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8865629", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718628", "map_id": "Q54SX3", "name": "MFSD2A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0282159", "map_id": "DDB_G0282159", "name": "MFSD2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679264", "map_id": "none", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_188458", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_188451", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10679261", "map_id": "Q54QC1", "name": "GPD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0283951", "map_id": "DDB_G0283951", "name": "GPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697686", "map_id": "none", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_2537690", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "species_10697678", "map_id": "none", "name": "NIPBL:MAU2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54S35", "map_id": "Q54S35", "name": "MAU2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282689", "map_id": "DDB_G0282689", "name": "MAU2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RK7", "map_id": "Q54RK7", "name": "NIPBL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283099", "map_id": "DDB_G0283099", "name": "NIPBL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697638", "map_id": "none", "name": "Cohesin:PDS5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QR0", "map_id": "Q54QR0", "name": "phospho-p-STAG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283681", "map_id": "DDB_G0283681", "name": "phospho-p-STAG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552Q7", "map_id": "Q552Q7", "name": "pds5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275929", "map_id": "DDB_G0275929", "name": "pds5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E85", "map_id": "Q54E85", "name": "smc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291752", "map_id": "DDB_G0291752", "name": "smc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550H7", "map_id": "Q550H7", "name": "phospho-p-S454-RAD21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276977", "map_id": "DDB_G0276977", "name": "phospho-p-S454-RAD21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552D9", "map_id": "Q552D9", "name": "smc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276101", "map_id": "DDB_G0276101", "name": "smc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697684", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10724623", "map_id": "none", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9619052", "map_id": "none", "name": "ACEI pro-drugs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6571", "map_id": "LigandDisplayForward?ligandId=6571", "name": "LigandDisplayForward?ligandId=6571", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6453", "map_id": "LigandDisplayForward?ligandId=6453", "name": "LigandDisplayForward?ligandId=6453", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6459", "map_id": "LigandDisplayForward?ligandId=6459", "name": "LigandDisplayForward?ligandId=6459", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6462", "map_id": "LigandDisplayForward?ligandId=6462", "name": "LigandDisplayForward?ligandId=6462", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6322", "map_id": "LigandDisplayForward?ligandId=6322", "name": "LigandDisplayForward?ligandId=6322", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:443874", "map_id": "pubchem.compound:443874", "name": "pubchem.compound:443874", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6575", "map_id": "LigandDisplayForward?ligandId=6575", "name": "LigandDisplayForward?ligandId=6575", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6456", "map_id": "LigandDisplayForward?ligandId=6456", "name": "LigandDisplayForward?ligandId=6456", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6374", "map_id": "LigandDisplayForward?ligandId=6374", "name": "LigandDisplayForward?ligandId=6374", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6350", "map_id": "LigandDisplayForward?ligandId=6350", "name": "LigandDisplayForward?ligandId=6350", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6377", "map_id": "LigandDisplayForward?ligandId=6377", "name": "LigandDisplayForward?ligandId=6377", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6339", "map_id": "LigandDisplayForward?ligandId=6339", "name": "LigandDisplayForward?ligandId=6339", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6367", "map_id": "LigandDisplayForward?ligandId=6367", "name": "LigandDisplayForward?ligandId=6367", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9619021", "map_id": "none", "name": "hydrolysed ACEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6378", "map_id": "LigandDisplayForward?ligandId=6378", "name": "LigandDisplayForward?ligandId=6378", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6576", "map_id": "LigandDisplayForward?ligandId=6576", "name": "LigandDisplayForward?ligandId=6576", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:443151", "map_id": "pubchem.compound:443151", "name": "pubchem.compound:443151", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6572", "map_id": "LigandDisplayForward?ligandId=6572", "name": "LigandDisplayForward?ligandId=6572", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6352", "map_id": "LigandDisplayForward?ligandId=6352", "name": "LigandDisplayForward?ligandId=6352", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6463", "map_id": "LigandDisplayForward?ligandId=6463", "name": "LigandDisplayForward?ligandId=6463", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6455", "map_id": "LigandDisplayForward?ligandId=6455", "name": "LigandDisplayForward?ligandId=6455", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6332", "map_id": "LigandDisplayForward?ligandId=6332", "name": "LigandDisplayForward?ligandId=6332", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6461", "map_id": "LigandDisplayForward?ligandId=6461", "name": "LigandDisplayForward?ligandId=6461", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6375", "map_id": "LigandDisplayForward?ligandId=6375", "name": "LigandDisplayForward?ligandId=6375", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6344", "map_id": "LigandDisplayForward?ligandId=6344", "name": "LigandDisplayForward?ligandId=6344", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6373", "map_id": "LigandDisplayForward?ligandId=6373", "name": "LigandDisplayForward?ligandId=6373", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6457", "map_id": "LigandDisplayForward?ligandId=6457", "name": "LigandDisplayForward?ligandId=6457", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709857", "map_id": "none", "name": "CES1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10675685", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675662", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54J82", "map_id": "Q54J82", "name": "SLBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288225", "map_id": "DDB_G0288225", "name": "SLBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75J91", "map_id": "Q75J91", "name": "SLBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675683", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675664", "map_id": "none", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675660", "map_id": "none", "name": "Homologues of SLBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675689", "map_id": "none", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675687", "map_id": "none", "name": "Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10682234", "map_id": "none", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_265287", "map_id": "CHEBI:15551", "name": "PGE2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682231", "map_id": "Q55FM3", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268042", "map_id": "DDB_G0268042", "name": "PTGES3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696143", "map_id": "none", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696140", "map_id": "none", "name": "HPGDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679144", "map_id": "none", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_177153", "map_id": "CHEBI:8082", "name": "phenylacetate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_177137", "map_id": "CHEBI:15537", "name": "phenylacetyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10677078", "map_id": "none", "name": "xenobiotic/medium-chain fatty acid:CoA ligases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8SSN6", "map_id": "Q8SSN6", "name": "ACSM5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276337", "map_id": "DDB_G0276337", "name": "ACSM5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551W4", "map_id": "Q551W4", "name": "ACSM5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677098", "map_id": "none", "name": "ACSM2B-like proteins transform ST to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159559", "map_id": "CHEBI:30762", "name": "ST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159557", "map_id": "CHEBI:32587", "name": "ST-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10677095", "map_id": "none", "name": "ACSM2B-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10677081", "map_id": "none", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159446", "map_id": "CHEBI:30746", "name": "BENZA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159447", "map_id": "CHEBI:15515", "name": "BEZ-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10723456", "map_id": "none", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723452", "map_id": "none", "name": "RAC2 plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556S2", "map_id": "Q556S2", "name": "pakH-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273121", "map_id": "DDB_G0273121", "name": "pakH-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JR7", "map_id": "Q54JR7", "name": "MCAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287833", "map_id": "DDB_G0287833", "name": "MCAM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IX1", "map_id": "Q86IX1", "name": "dst1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274593", "map_id": "DDB_G0274593", "name": "dst1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JN1", "map_id": "Q86JN1", "name": "STBD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272062", "map_id": "DDB_G0272062", "name": "STBD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676533", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9GPQ8", "map_id": "Q9GPQ8", "name": "racL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292816", "map_id": "DDB_G0292816", "name": "racL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723454", "map_id": "none", "name": "RAC2:GTP:RAC2 cytosolic effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703564", "map_id": "none", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10676526", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10703557", "map_id": "none", "name": "NOX3 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q867T7", "map_id": "Q867T7", "name": "ncfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288773", "map_id": "DDB_G0288773", "name": "ncfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q867X6", "map_id": "Q867X6", "name": "cybA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267460", "map_id": "DDB_G0267460", "name": "cybA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86GL4", "map_id": "Q86GL4", "name": "noxB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287101", "map_id": "DDB_G0287101", "name": "noxB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F44", "map_id": "Q54F44", "name": "noxC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291117", "map_id": "DDB_G0291117", "name": "noxC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYS3", "map_id": "Q9XYS3", "name": "noxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289653", "map_id": "DDB_G0289653", "name": "noxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703559", "map_id": "none", "name": "NOX3 complex:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10726069", "map_id": "none", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10726067", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10726063", "map_id": "none", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10726050", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10703562", "map_id": "none", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_3299686", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10723450", "map_id": "none", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723366", "map_id": "none", "name": "Homologues of ARHGDIA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10723444", "map_id": "none", "name": "RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723448", "map_id": "none", "name": "ARHGDIA:RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723813", "map_id": "none", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723796", "map_id": "none", "name": "RHOBTB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10723809", "map_id": "none", "name": "RHOBTB1 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CB2", "map_id": "Q55CB2", "name": "DBN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290593", "map_id": "DDB_G0290593", "name": "DBN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XF1", "map_id": "Q54XF1", "name": "RBBP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279003", "map_id": "DDB_G0279003", "name": "RBBP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557J6", "map_id": "Q557J6", "name": "abpE-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273447", "map_id": "DDB_G0273447", "name": "abpE-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CB3", "map_id": "Q55CB3", "name": "DBN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KL1", "map_id": "Q86KL1", "name": "bre1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274241", "map_id": "DDB_G0274241", "name": "bre1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ES9", "map_id": "Q54ES9", "name": "cct2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291358", "map_id": "DDB_G0291358", "name": "cct2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y26", "map_id": "Q54Y26", "name": "ndrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278457", "map_id": "DDB_G0278457", "name": "ndrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ER7", "map_id": "Q54ER7", "name": "cct7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291225", "map_id": "DDB_G0291225", "name": "cct7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JM6", "map_id": "Q75JM6", "name": "TXNL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276057", "map_id": "DDB_G0276057", "name": "TXNL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FU0", "map_id": "Q54FU0", "name": "DBN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723811", "map_id": "none", "name": "RHOBTB1:GTP:RHOBTB1 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10723162", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10695507", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723159", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PB7", "map_id": "Q54PB7", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292004", "map_id": "DDB_G0292004", "name": "DOCK4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550V3", "map_id": "Q550V3", "name": "ARHGEF18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277017", "map_id": "DDB_G0277017", "name": "ARHGEF18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS6", "map_id": "Q54DS6", "name": "docA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291974", "map_id": "DDB_G0291974", "name": "docA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BQ8", "map_id": "Q55BQ8", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DW1", "map_id": "Q54DW1", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725982", "map_id": "none", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10725978", "map_id": "none", "name": "RHOBTB3 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q552H0", "map_id": "Q552H0", "name": "RAB9A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294571", "map_id": "DDB_G0294571", "name": "RAB9A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK8", "map_id": "Q54FK8", "name": "rabM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290829", "map_id": "DDB_G0290829", "name": "rabM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB8", "map_id": "Q1ZXB8", "name": "RAB9A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK4", "map_id": "Q54FK4", "name": "rabK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290833", "map_id": "DDB_G0290833", "name": "rabK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K69", "map_id": "Q54K69", "name": "rab7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287553", "map_id": "DDB_G0287553", "name": "rab7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK2", "map_id": "Q54FK2", "name": "rabN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290793", "map_id": "DDB_G0290793", "name": "rabN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB9", "map_id": "Q1ZXB9", "name": "rabK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290831", "map_id": "DDB_G0290831", "name": "rabK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK5", "map_id": "Q54FK5", "name": "rabN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290789", "map_id": "DDB_G0290789", "name": "rabN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB7", "map_id": "Q1ZXB7", "name": "rabK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290791", "map_id": "DDB_G0290791", "name": "rabK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK7", "map_id": "Q54FK7", "name": "rabL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290779", "map_id": "DDB_G0290779", "name": "rabL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725976", "map_id": "none", "name": "RHOBTB3:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10725980", "map_id": "none", "name": "RHOBTB3:ATP:RHOBTB3 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10723744", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723740", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I58", "map_id": "Q54I58", "name": "nipsnap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288989", "map_id": "DDB_G0288989", "name": "nipsnap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P92", "map_id": "Q54P92", "name": "mtr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284699", "map_id": "DDB_G0284699", "name": "mtr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BQ5", "map_id": "Q54BQ5", "name": "nsfl1c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293498", "map_id": "DDB_G0293498", "name": "nsfl1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TR7", "map_id": "Q54TR7", "name": "bkdC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281797", "map_id": "DDB_G0281797", "name": "bkdC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HZ4", "map_id": "Q54HZ4", "name": "WDR11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289123", "map_id": "DDB_G0289123", "name": "WDR11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90532", "map_id": "P90532", "name": "cdcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P30", "map_id": "Q54P30", "name": "RALGAPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284825", "map_id": "DDB_G0284825", "name": "RALGAPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T158", "map_id": "Q8T158", "name": "fam91", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274247", "map_id": "DDB_G0274247", "name": "fam91", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723682", "map_id": "none", "name": "RHOH:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723742", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723589", "map_id": "none", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723581", "map_id": "none", "name": "RHOJ:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723579", "map_id": "none", "name": "RHOJ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10689591", "map_id": "none", "name": "Homologues of DOCK8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10702646", "map_id": "none", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10702635", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10680761", "map_id": "none", "name": "CALM1:4Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702641", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725989", "map_id": "none", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10725986", "map_id": "none", "name": "RHOBTB3:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10726061", "map_id": "none", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10726057", "map_id": "none", "name": "RAC2 mitochondrial effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q55DS3", "map_id": "Q55DS3", "name": "SAMM50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269550", "map_id": "DDB_G0269550", "name": "SAMM50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10726059", "map_id": "none", "name": "RAC2:GTP:RAC2 mitochondrial effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10702637", "map_id": "none", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702633", "map_id": "none", "name": "IQGAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723890", "map_id": "none", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723880", "map_id": "none", "name": "RAC3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34147", "map_id": "P34147", "name": "racA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286555", "map_id": "DDB_G0286555", "name": "racA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723878", "map_id": "none", "name": "RAC3:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723887", "map_id": "none", "name": "RAC3 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723688", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723680", "map_id": "none", "name": "Homologues of RHOH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723759", "map_id": "none", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723748", "map_id": "none", "name": "RHOU:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723755", "map_id": "none", "name": "RHOU effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q553T4", "map_id": "Q553T4", "name": "USP9X", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292046", "map_id": "DDB_G0292046", "name": "USP9X", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DT4", "map_id": "Q54DT4", "name": "USP9X", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723757", "map_id": "none", "name": "RHOU:GTP:RHOU effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10712144", "map_id": "none", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1524165", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629751", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10712141", "map_id": "none", "name": "PIK3C3:PIK3R4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10722712", "map_id": "none", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683656", "map_id": "none", "name": "PAK3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10683654", "map_id": "Q55GV3", "name": "pakC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702660", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10726075", "map_id": "none", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10726073", "map_id": "none", "name": "RAC3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723466", "map_id": "none", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723463", "map_id": "none", "name": "RAC2 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674723", "map_id": "none", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674719", "map_id": "none", "name": "14-3-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10674690", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283617", "map_id": "DDB_G0283617", "name": "phospho-cdc25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674721", "map_id": "none", "name": "p-S216-CDC25C:14-3-3 protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QM6", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723374", "map_id": "none", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723370", "map_id": "none", "name": "ARHGDIA,ARHGDIB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10723372", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723874", "map_id": "none", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723872", "map_id": "none", "name": "RHOV:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10723864", "map_id": "none", "name": "RHOV:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703581", "map_id": "none", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703572", "map_id": "none", "name": "Smooth muscle/non-muscle myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13833", "map_id": "P13833", "name": "phospho-mlcR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276077", "map_id": "DDB_G0276077", "name": "phospho-mlcR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09402", "map_id": "P09402", "name": "mlcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277859", "map_id": "DDB_G0277859", "name": "mlcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08799", "map_id": "P08799", "name": "mhcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286355", "map_id": "DDB_G0286355", "name": "mhcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703578", "map_id": "none", "name": "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10702680", "map_id": "none", "name": "Homologues of p-S141,T402-PAK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703534", "map_id": "none", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703530", "map_id": "none", "name": "NOX1 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10703532", "map_id": "none", "name": "NOX1 complex:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725984", "map_id": "none", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10725974", "map_id": "none", "name": "Homologues of RHOBTB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10723906", "map_id": "none", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723902", "map_id": "none", "name": "RAC3 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10723904", "map_id": "none", "name": "RAC3:GTP:RAC3 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723586", "map_id": "none", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723583", "map_id": "none", "name": "RHOJ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10726106", "map_id": "none", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10726100", "map_id": "none", "name": "p-Y254-RHOU:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10726104", "map_id": "none", "name": "p-Y254-RHOU:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10723461", "map_id": "none", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10723458", "map_id": "none", "name": "RAC2 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723354", "map_id": "none", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723350", "map_id": "none", "name": "RAC1 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WW0", "map_id": "Q54WW0", "name": "NISCH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290421", "map_id": "DDB_G0290421", "name": "NISCH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G40", "map_id": "Q54G40", "name": "NISCH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723352", "map_id": "none", "name": "RAC1:GTP:RAC1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702689", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702662", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702686", "map_id": "none", "name": "p-S,T-PAK1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723870", "map_id": "none", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723866", "map_id": "none", "name": "RHOV effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10723868", "map_id": "none", "name": "RHOV:GTP:RHOV effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702643", "map_id": "none", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702639", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAP:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723898", "map_id": "none", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723892", "map_id": "none", "name": "RAC3 GDIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10723896", "map_id": "none", "name": "RAC3:GDP:RAC3 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723798", "map_id": "none", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10723794", "map_id": "none", "name": "Homologues of RHOBTB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10703537", "map_id": "none", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10723885", "map_id": "none", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723882", "map_id": "none", "name": "RAC3 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723290", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723287", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725875", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10725873", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10722714", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683652", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10683650", "map_id": "none", "name": "Homologues of PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10702658", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723764", "map_id": "none", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723761", "map_id": "none", "name": "RHOU:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723468", "map_id": "none", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703511", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10723686", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10723684", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723860", "map_id": "none", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10723845", "map_id": "none", "name": "RHOBTB2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10723856", "map_id": "none", "name": "RHOBTB2 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q76NU3", "map_id": "Q76NU3", "name": "cct6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277493", "map_id": "DDB_G0277493", "name": "cct6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869T1", "map_id": "Q869T1", "name": "twfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274437", "map_id": "DDB_G0274437", "name": "twfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR6", "map_id": "Q55CR6", "name": "DDX39B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269932", "map_id": "DDB_G0269932", "name": "DDX39B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723858", "map_id": "none", "name": "RHOBTB2:GTP:RHOBTB2 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10682167", "map_id": "none", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10682163", "map_id": "Q54IY4", "name": "phospho-p-S387-RFWD2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10682165", "map_id": "Q54IY4", "name": "phospho-p-S387-RFWD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10682358", "map_id": "none", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10682348", "map_id": "Q54IY4", "name": "RFWD2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10682172", "map_id": "none", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682169", "map_id": "none", "name": "ubiquitinated phospho-COP1(ser-387)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10682174", "map_id": "none", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10684699", "map_id": "none", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10684682", "map_id": "none", "name": "Chromatin with acetylated H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427523", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_427498", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_427497", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10682100", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10684696", "map_id": "none", "name": "eNoSC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CP1", "map_id": "Q54CP1", "name": "rrp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292960", "map_id": "DDB_G0292960", "name": "rrp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GV7", "map_id": "Q54GV7", "name": "sir2D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289967", "map_id": "DDB_G0289967", "name": "sir2D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684702", "map_id": "none", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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}, { "id": "Q54DM4", "map_id": "Q54DM4", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557I6", "map_id": "Q557I6", "name": "MIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273399", "map_id": "DDB_G0273399", "name": "MIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP7", "map_id": "Q54LP7", "name": "ube2j2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286511", "map_id": "DDB_G0286511", "name": "ube2j2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7FZX3", "map_id": 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"name": "UBE2J1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281369", "map_id": "DDB_G0281369", "name": "UBE2J1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6T486", "map_id": "Q6T486", "name": "rbrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286961", "map_id": "DDB_G0286961", "name": "rbrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EY8", "map_id": "Q55EY8", "name": "ube2w", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268938", "map_id": "DDB_G0268938", "name": "ube2w", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EF6", "map_id": "Q54EF6", "name": "UBE3D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291612", "map_id": "DDB_G0291612", "name": "UBE3D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555G0", "map_id": "Q555G0", "name": "UBE2O", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274897", "map_id": "DDB_G0274897", "name": "UBE2O", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PV3", "map_id": "Q54PV3", "name": "RNF19B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G038", "map_id": "C7G038", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557E7", "map_id": "Q557E7", "name": "cblA-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273141", "map_id": "DDB_G0273141", "name": "cblA-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J27", "map_id": "Q54J27", "name": "UBE2U", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689255", "map_id": "none", "name": "E3:Ub:substrate", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689247", "map_id": "none", "name": "E2 Ubiquitin-conjugating enzyme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689128", "map_id": "none", "name": "E3 ligases in proteasomal degradation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689274", "map_id": "none", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983123", "map_id": "none", "name": "K48polyUb-antigenic substrate", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983032", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (8-16aa)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983036", "map_id": "CHEBI:25676", "name": "precursor peptide fragment (>16 aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942986", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10689362", "map_id": "none", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689359", "map_id": "none", "name": "IFN gamma stimulated aminopeptidases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557I4", "map_id": "Q557I4", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273419", "map_id": "DDB_G0273419", "name": "ERAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CT4", "map_id": "Q55CT4", "name": "psaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270994", "map_id": "DDB_G0270994", "name": "psaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CY7", "map_id": "Q55CY7", "name": "psaB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270670", "map_id": "DDB_G0270670", "name": "psaB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721580", "map_id": "none", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955634", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (3-7aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721577", "map_id": "Q54DD2", "name": "THOP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292362", "map_id": "DDB_G0292362", "name": "THOP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681335", "map_id": "none", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681143", "map_id": "none", "name": "SAR1B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q559R0", "map_id": "Q559R0", "name": "sarA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272296", "map_id": "DDB_G0272296", "name": "sarA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681331", "map_id": "none", "name": "SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T59", "map_id": "Q54T59", "name": "sec23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281985", "map_id": "DDB_G0281985", "name": "sec23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z72", "map_id": "Q54Z72", "name": "sec24l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277797", "map_id": "DDB_G0277797", "name": "sec24l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U61", "map_id": "Q54U61", "name": "sec24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281255", "map_id": "DDB_G0281255", "name": "sec24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681333", "map_id": "none", "name": "SAR1B:GTP:SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10689306", "map_id": "none", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689298", "map_id": "none", "name": "Ubiquitin activating E1 enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54C02", "map_id": "Q54C02", "name": "uba5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293306", "map_id": "DDB_G0293306", "name": "uba5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550P6", "map_id": "Q550P6", "name": "UBA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277047", "map_id": "DDB_G0277047", "name": "UBA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689300", "map_id": "none", "name": "E1 bound ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689303", "map_id": "none", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689249", "map_id": "none", "name": "Ubiquitin:E2 conjugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689341", "map_id": "none", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983034", "map_id": "CHEBI:25676", "name": "oligopeptide fragment", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_983033", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8943716", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10689338", "map_id": "none", "name": "ERAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10689309", "map_id": "none", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689270", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689311", "map_id": "none", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983035", "map_id": "none", "name": "antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10689272", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10690050", "map_id": "none", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1236719", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10722775", "map_id": "none", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722754", "map_id": "none", "name": "G alpha (q):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54LD1", "map_id": "Q54LD1", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286817", "map_id": "DDB_G0286817", "name": "RGS16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556I3", "map_id": "Q556I3", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722772", "map_id": "none", "name": "G alpha (q):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684253", "map_id": "none", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10676141", "map_id": "none", "name": "G protein alpha:GTP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10684218", "map_id": "none", "name": "G-protein alpha (q/11):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10684251", "map_id": "none", "name": "RGS proteins active for G alpha (q)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10676760", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676657", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10684674", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684665", "map_id": "P34125", "name": "dgkA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0277223", "map_id": "DDB_G0277223", "name": "dgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722756", "map_id": "none", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722752", "map_id": "none", "name": "RGS1,2,3,4,5,13,16,17,18,19,21", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684660", "map_id": "none", "name": "2-AG hydrolysis to arachidonate by MAGL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426030", "map_id": "CHEBI:52392", "name": "2AG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_422506", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10684657", "map_id": "Q55EQ3", "name": "MGLL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10722777", "map_id": "none", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10684652", "map_id": "none", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426026", "map_id": "CHEBI:35366", "name": "Fatty Acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10684649", "map_id": "none", "name": "Diacylglycerol lipase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54YL1", "map_id": "Q54YL1", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291354", "map_id": "DDB_G0291354", "name": "DAGLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GX3", "map_id": "Q54GX3", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET1", "map_id": "Q54ET1", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676646", "map_id": "none", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10676641", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10676643", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):DAG:IP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10673792", "map_id": "none", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83960", "map_id": "CHEBI:17821", "name": "Thy", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_73541", "map_id": "CHEBI:27468", "name": "5,6-Dihydrothymine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673737", "map_id": "none", "name": "DPYD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FT1", "map_id": "Q55FT1", "name": "pyd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267966", "map_id": "DDB_G0267966", "name": "pyd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673796", "map_id": "none", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73617", "map_id": "CHEBI:74414", "name": "UIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73619", "map_id": "CHEBI:57731", "name": "3AIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673757", "map_id": "none", "name": "UPB1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q964D8", "map_id": "Q964D8", "name": "pyd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274123", "map_id": "DDB_G0274123", "name": "pyd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674384", "map_id": "none", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_112016", "map_id": "CHEBI:57720", "name": "R1P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:58576", "map_id": "CHEBI:58576", "name": "CHEBI:58576", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83962", "map_id": "CHEBI:17568", "name": "Ura", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674379", "map_id": "none", "name": "UPP1, UPP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PM8", "map_id": "Q54PM8", "name": "udpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284431", "map_id": "DDB_G0284431", "name": "udpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673794", "map_id": "none", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673747", "map_id": "none", "name": "DPYS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DL0", "map_id": "Q55DL0", "name": "pyd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269246", "map_id": "DDB_G0269246", "name": "pyd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673760", "map_id": "none", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73588", "map_id": "CHEBI:11892", "name": "UPROP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73590", "map_id": "CHEBI:57966", "name": "b-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673740", "map_id": "none", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73584", "map_id": "CHEBI:15901", "name": "5,6-Dihydrouracil", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673750", "map_id": "none", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675646", "map_id": "none", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77341", "map_id": "CHEBI:28325", "name": "(S)-Hydroxydecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671325", "map_id": "none", "name": "ECHS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q1ZXF1", "map_id": "Q1ZXF1", "name": "echs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285071", "map_id": "DDB_G0285071", "name": "echs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722311", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10722308", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54YT4", "map_id": "Q54YT4", "name": "mecr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278095", "map_id": "DDB_G0278095", "name": "mecr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679923", "map_id": "none", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10679514", "map_id": "none", "name": "planar gap junction plaques associated with Dab2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10679534", "map_id": "none", "name": "Dynamin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10679536", "map_id": "none", "name": "Planar gap junction plaques associated with Dab2 and Dynamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10669451", "map_id": "none", "name": "ORC2 binds ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669447", "map_id": "Q55BR6", "name": "orcC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271078", "map_id": "DDB_G0271078", "name": "orcC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669442", "map_id": "Q55CU7", "name": "orcB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269894", "map_id": "DDB_G0269894", "name": "orcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669449", "map_id": "none", "name": "ORC2:ORC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55CU7", "map_id": "Q55CU7", "name": "orcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BR6", "map_id": "Q55BR6", "name": "orcC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10669460", "map_id": "none", "name": "ORC5 binds ORC2:ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669456", "map_id": "Q54C22", "name": "orcE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293214", "map_id": "DDB_G0293214", "name": "orcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669458", "map_id": "none", "name": "ORC2:ORC3:ORC5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C22", "map_id": "Q54C22", "name": "orcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726116", "map_id": "none", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10726114", "map_id": "Q54RM2", "name": "orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283073", "map_id": "DDB_G0283073", "name": "phospho-orcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669474", "map_id": "Q54RM2", "name": "orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10669494", "map_id": "none", "name": "Formation of ORC(1-6) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669482", "map_id": "none", "name": "ORC(1-5):origin of replication", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86AD6", "map_id": "Q86AD6", "name": "orcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271562", "map_id": "DDB_G0271562", "name": "orcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RM2", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669490", "map_id": "Q54P62", "name": "phospho-orcF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284771", "map_id": "DDB_G0284771", "name": "orcF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669492", "map_id": "none", "name": "ORC(1-6):origin of replication", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P62", "map_id": "Q54P62", "name": "orcF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726142", "map_id": "none", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10726138", "map_id": "none", "name": "H4K20Me2-nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10726140", "map_id": "none", "name": "ORC1:H4K20Me2-nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669469", "map_id": "none", "name": "Formation of ORC(2-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669465", "map_id": "Q86AD6", "name": "orcD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669467", "map_id": "none", "name": "ORC(2-5)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669484", "map_id": "none", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669478", "map_id": "none", "name": "ORC1:origin of replication", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10696023", "map_id": "none", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2142896", "map_id": "none", "name": "HA polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2162224", "map_id": "CHEBI:64024", "name": "GlcA-\u00ce\u00b21,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2160848", "map_id": "none", "name": "HA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10709790", "map_id": "none", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5693343", "map_id": "CHEBI:64024", "name": "GlcA-b1,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10709787", "map_id": "none", "name": "Homologues of CEMIP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54KF6", "map_id": "Q54KF6", "name": "CEMIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287365", "map_id": "DDB_G0287365", "name": "CEMIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D62", "map_id": "Q55D62", "name": "CEMIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702727", "map_id": "none", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702719", "map_id": "none", "name": "SESN1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WU6", "map_id": "Q54WU6", "name": "SESN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279427", "map_id": "DDB_G0279427", "name": "SESN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702725", "map_id": "none", "name": "SESN1,2,3:p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10714788", "map_id": "none", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714777", "map_id": "none", "name": "RGGT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B0G172", "map_id": "B0G172", "name": "rabggtb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290671", "map_id": "DDB_G0290671", "name": "rabggtb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DQ4", "map_id": "Q55DQ4", "name": "rabggta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269570", "map_id": "DDB_G0269570", "name": "rabggta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714784", "map_id": "Q54VT9", "name": "CHM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280143", "map_id": "DDB_G0280143", "name": "CHML", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714786", "map_id": "none", "name": "RGGT:CHM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54VT9", "map_id": "Q54VT9", "name": "CHML", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711995", "map_id": "none", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676302", "map_id": "Q54LJ0", "name": "CCNK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286617", "map_id": "DDB_G0286617", "name": "CCNT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711991", "map_id": "Q556Z2", "name": "CDK12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0273207", "map_id": "DDB_G0273207", "name": "CDK9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711993", "map_id": "none", "name": "CCNK:CDK12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LJ0", "map_id": "Q54LJ0", "name": "CCNT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Z2", "map_id": "Q556Z2", "name": "CDK9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714779", "map_id": "none", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10714775", "map_id": "B0G172", "name": "rabggtb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10714770", "map_id": "Q55DQ4", "name": "rabggta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10683116", "map_id": "none", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10711979", "map_id": "none", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711969", "map_id": "none", "name": "Homologues of SGK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10711977", "map_id": "none", "name": "Homologues of p-S422-SGK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10714366", "map_id": "none", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799725", "map_id": "CHEBI:34055", "name": "1,2-Naphthoquinone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799726", "map_id": "CHEBI:15817", "name": "semiquinone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10714301", "map_id": "none", "name": "TP53I3 Dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75JT6", "map_id": "Q75JT6", "name": "TP53I3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272440", "map_id": "DDB_G0272440", "name": "TP53I3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714807", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10714802", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54KL1", "map_id": "Q54KL1", "name": "TRIAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287279", "map_id": "DDB_G0287279", "name": "TRIAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G07", "map_id": "Q54G07", "name": "slmo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290499", "map_id": "DDB_G0290499", "name": "slmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712027", "map_id": "none", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10712011", "map_id": "none", "name": "CCNK:CDK12:Elongation Complex at DNA Repair Genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54YG9", "map_id": "Q54YG9", "name": "tcea1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278241", "map_id": "DDB_G0278241", "name": "tcea1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F13", "map_id": "Q55F13", "name": "NELFCD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268678", "map_id": "DDB_G0268678", "name": "NELFCD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q08", "map_id": "Q54Q08", "name": "NELFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284195", "map_id": "DDB_G0284195", "name": "NELFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NF2", "map_id": "Q54NF2", "name": "spt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285293", "map_id": "DDB_G0285293", "name": "spt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JA4", "map_id": "Q75JA4", "name": "CTDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271690", "map_id": "DDB_G0271690", "name": "CTDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712024", "map_id": "none", "name": "CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10714862", "map_id": "none", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674703", "map_id": "P54632", "name": "fttB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674705", "map_id": "none", "name": "SFN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671942", "map_id": "none", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111745", "map_id": "CHEBI:58297", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671939", "map_id": "none", "name": "GSR-2:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T137", "map_id": "Q8T137", "name": "gsr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272754", "map_id": "DDB_G0272754", "name": "gsr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670932", "map_id": "none", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670929", "map_id": "none", "name": "G6PD dimer and tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557D2", "map_id": "Q557D2", "name": "g6pd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273131", "map_id": "DDB_G0273131", "name": "g6pd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712135", "map_id": "none", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10712067", "map_id": "Q54NU5", "name": "btg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285069", "map_id": "DDB_G0285069", "name": "btg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712131", "map_id": "none", "name": "CCR4-NOT Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXI2", "map_id": "Q1ZXI2", "name": "cnot11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279005", "map_id": "DDB_G0279005", "name": "cnot11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HH3", "map_id": "Q54HH3", "name": "CNOT6L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289461", "map_id": "DDB_G0289461", "name": "CNOT6L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG2", "map_id": "Q54PG2", "name": "CNOT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284577", "map_id": "DDB_G0284577", "name": "CNOT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG7", "map_id": "Q54NG7", "name": "CNOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285269", "map_id": "DDB_G0285269", "name": "CNOT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554L0", "map_id": "Q554L0", "name": "CNOT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275005", "map_id": "DDB_G0275005", "name": "CNOT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U17", "map_id": "Q54U17", "name": "CNOT10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281363", "map_id": "DDB_G0281363", "name": "CNOT10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PZ4", "map_id": "Q54PZ4", "name": "CNOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D59", "map_id": "Q55D59", "name": "RQCD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269778", "map_id": "DDB_G0269778", "name": "RQCD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AA8", "map_id": "Q55AA8", "name": "CNOT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272056", "map_id": "DDB_G0272056", "name": "CNOT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JL4", "map_id": "Q75JL4", "name": "DG1040", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276029", "map_id": "DDB_G0276029", "name": "DG1040", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712133", "map_id": "none", "name": "BTG2:CCR4-NOT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NU5", "map_id": "Q54NU5", "name": "btg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714804", "map_id": "none", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10714798", "map_id": "Q54G07", "name": "slmo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10714793", "map_id": "Q54KL1", "name": "TRIAP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10714845", "map_id": "none", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674683", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10714828", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10714842", "map_id": "none", "name": "Homologues of PLK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55G55", "map_id": "Q55G55", "name": "PLK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267810", "map_id": "DDB_G0267810", "name": "PLK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BR8", "map_id": "Q54BR8", "name": "cbfB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293470", "map_id": "DDB_G0293470", "name": "cbfB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711989", "map_id": "none", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10711987", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10712001", "map_id": "none", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10711997", "map_id": "Q556Z2", "name": "CDK13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10711999", "map_id": "none", "name": "CCNK:CDK13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702731", "map_id": "none", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680124", "map_id": "Q54VB2", "name": "phospho-p-S939,T1462-TSC2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280527", "map_id": "DDB_G0280527", "name": "phospho-p-S939,T1462-TSC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702729", "map_id": "none", "name": "p-S939,T1462-TSC2:14-3-3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VB2", "map_id": "Q54VB2", "name": "phospho-p-S939,T1462-TSC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712029", "map_id": "none", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10712009", "map_id": "none", "name": "Elongation Complex at DNA Repair Genes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10714303", "map_id": "none", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714299", "map_id": "Q75JT6", "name": "TP53I3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10699328", "map_id": "none", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699325", "map_id": "none", "name": "PRDX1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N76", "map_id": "Q54N76", "name": "PRDX5-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285741", "map_id": "DDB_G0285741", "name": "PRDX5-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555L5", "map_id": "Q555L5", "name": "prdx4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274859", "map_id": "DDB_G0274859", "name": "prdx4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714091", "map_id": "none", "name": "ATM phosphorylates ZNF420", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10688366", "map_id": "Q54UG9", "name": "TFIIIA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281085", "map_id": "DDB_G0281085", "name": "TFIIIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714089", "map_id": "Q54UG9", "name": "phospho-TFIIIA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10702706", "map_id": "none", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699317", "map_id": "none", "name": "PRDX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10702703", "map_id": "none", "name": "HOOS-C52-PRDX1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680127", "map_id": "none", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677425", "map_id": "Q54VB2", "name": "TSC2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10702723", "map_id": "none", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702721", "map_id": "none", "name": "SESN1,2,3:HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723422", "map_id": "none", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013199", "map_id": "CHEBI:18407", "name": "HCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9012592", "map_id": "CHEBI:16208", "name": "3MPYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013191", "map_id": "CHEBI:29200", "name": "HSCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10723093", "map_id": "Q54E40", "name": "MPST", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0291816", "map_id": "DDB_G0291816", "name": "CysS248-MPST", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723420", "map_id": "none", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614595", "map_id": "CHEBI:16094", "name": "S2O3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013207", "map_id": "CHEBI:17359", "name": "SO3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10692485", "map_id": "none", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614532", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692474", "map_id": "none", "name": "PXLP-K212-CTH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DV9", "map_id": "Q55DV9", "name": "cysA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269122", "map_id": "DDB_G0269122", "name": "cysA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724254", "map_id": "none", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10724250", "map_id": "none", "name": "CysS248-MPST:TXN2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NX3", "map_id": "Q54NX3", "name": "2xHC-TXN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284939", "map_id": "DDB_G0284939", "name": "2xHC-TXN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E40", "map_id": "Q54E40", "name": "CysS248-MPST", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1655881", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10699273", "map_id": "Q54NX3", "name": "2xHC-TXN2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10716446", "map_id": "none", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6814151", "map_id": "CHEBI:17141", "name": "2AET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10716443", "map_id": "none", "name": "ADO:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556I2", "map_id": "Q556I2", "name": "ado-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273031", "map_id": "DDB_G0273031", "name": "ado-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724248", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10724246", "map_id": "Q54E40", "name": "CysS248-MPST", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10724252", "map_id": "none", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10699270", "map_id": "Q54NX3", "name": "TXN2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10692483", "map_id": "none", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614582", "map_id": "CHEBI:21347", "name": "L-Lanthionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10692466", "map_id": "none", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1614584", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10723096", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012724", "map_id": "CHEBI:17137", "name": "HSO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10692464", "map_id": "none", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614538", "map_id": "CHEBI:17359", "name": "sulfite(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10692461", "map_id": "none", "name": "holo-SUOX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q54XJ8", "map_id": "Q54XJ8", "name": "SUOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278893", "map_id": "DDB_G0278893", "name": "SUOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692498", "map_id": "none", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614519", "map_id": "CHEBI:16345", "name": "3-Sulfinoalanine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692495", "map_id": "none", "name": "CDO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K68", "map_id": "Q54K68", "name": "CDO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287555", "map_id": "DDB_G0287555", "name": "CDO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723424", "map_id": "none", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013543", "map_id": "LigandDisplayForward?ligandId=9830", "name": "sulfanegen", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10692477", "map_id": "none", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614594", "map_id": "CHEBI:62856", "name": "HLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10692488", "map_id": "none", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10723006", "map_id": "none", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9010792", "map_id": "LigandDisplayForward?ligandId=4518", "name": "DCA", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301973", "map_id": "CHEBI:17883", "name": "HCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10723003", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "Q54YN2", "map_id": "Q54YN2", "name": "mai", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278155", "map_id": "DDB_G0278155", "name": "mai", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1655887", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10677142", "map_id": "none", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_449299", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162681", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677139", "map_id": "none", "name": "DPM1:DPM2:DPM3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q556K9", "map_id": "Q556K9", "name": "dpm2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272588", "map_id": "DDB_G0272588", "name": "dpm2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP3", "map_id": "Q54LP3", "name": "dpm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286519", "map_id": "DDB_G0286519", "name": "dpm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NT6", "map_id": "Q76NT6", "name": "dpm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277435", "map_id": "DDB_G0277435", "name": "dpm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681323", "map_id": "none", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10681315", "map_id": "none", "name": "SAR1B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10681320", "map_id": "Q54M76", "name": "PREB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286167", "map_id": "DDB_G0286167", "name": "PREB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710261", "map_id": "none", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681221", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8T2J5", "map_id": "Q8T2J5", "name": "LMAN2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271968", "map_id": "DDB_G0271968", "name": "LMAN2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZH1", "map_id": "Q54ZH1", "name": "syn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277565", "map_id": "DDB_G0277565", "name": "syn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VR1", "map_id": "Q54VR1", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280187", "map_id": "DDB_G0280187", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556P7", "map_id": "Q556P7", "name": "LMAN1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281139", "map_id": "DDB_G0281139", "name": "LMAN1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UD7", "map_id": "Q54UD7", "name": "LMAN1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I39", "map_id": "Q86I39", "name": "LMAN1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FD0", "map_id": "Q55FD0", "name": "GOSR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268452", "map_id": "DDB_G0268452", "name": "GOSR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681223", "map_id": "none", "name": "COPII cargo receptors:SAR1B:GTP:SEC23:SEC24", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10710091", "map_id": "none", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681161", "map_id": "Q54T59", "name": "sec23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681325", "map_id": "Q54U61", "name": "sec24", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710089", "map_id": "none", "name": "SEC24A,B:SEC23A:SEC22B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10715624", "map_id": "none", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10715620", "map_id": "none", "name": "Dynein:Dynactin:microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I79", "map_id": "Q54I79", "name": "arpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288937", "map_id": "DDB_G0288937", "name": "arpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CI8", "map_id": "Q54CI8", "name": "dync1li1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292904", "map_id": "DDB_G0292904", "name": "dync1li1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VS0", "map_id": "Q54VS0", "name": "dynD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280175", "map_id": "DDB_G0280175", "name": "dynD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13021", "map_id": "P13021", "name": "acpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267374", "map_id": "DDB_G0267374", "name": "acpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13022", "map_id": "P13022", "name": "acpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272104", "map_id": "DDB_G0272104", "name": "acpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XU5", "map_id": "Q54XU5", "name": "dynE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278579", "map_id": "DDB_G0278579", "name": "dynE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N50", "map_id": "Q54N50", "name": "dynB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285503", "map_id": "DDB_G0285503", "name": "dynB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54703", "map_id": "P54703", "name": "dicA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280849", "map_id": "DDB_G0280849", "name": "dicA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VD6", "map_id": "Q54VD6", "name": "dynA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280435", "map_id": "DDB_G0280435", "name": "dynA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A88", "map_id": "Q86A88", "name": "dlcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274815", "map_id": "DDB_G0274815", "name": "dlcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FM4", "map_id": "Q54FM4", "name": "dynF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290757", "map_id": "DDB_G0290757", "name": "dynF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JY2", "map_id": "Q54JY2", "name": "arpH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287739", "map_id": "DDB_G0287739", "name": "arpH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZI7", "map_id": "Q54ZI7", "name": "dynC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277561", "map_id": "DDB_G0277561", "name": "dynC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34036", "map_id": "P34036", "name": "dhcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276355", "map_id": "DDB_G0276355", "name": "dhcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715492", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "Q550R2", "map_id": "Q550R2", "name": "ctxB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276893", "map_id": "DDB_G0276893", "name": "ctxB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553R1", "map_id": "Q553R1", "name": "USO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275331", "map_id": "DDB_G0275331", "name": "USO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXJ2", "map_id": "Q1ZXJ2", "name": "SPTBN5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294557", "map_id": "DDB_G0294557", "name": "SPTBN5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JP5", "map_id": "Q75JP5", "name": "SPTBN5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BK5", "map_id": "Q54BK5", "name": "PalmC-YKT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293712", "map_id": "DDB_G0293712", "name": "PalmC-YKT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SJ2", "map_id": "Q54SJ2", "name": "BET1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282433", "map_id": "DDB_G0282433", "name": "BET1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715622", "map_id": "none", "name": "RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10715495", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10715384", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10716722", "map_id": "none", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10716717", "map_id": "none", "name": "RAB1:GTP:TBC1D20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54RT5", "map_id": "Q54RT5", "name": "TBC1D20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283055", "map_id": "DDB_G0283055", "name": "TBC1D20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716715", "map_id": "Q54RT5", "name": "TBC1D20", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10710154", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10710150", "map_id": "none", "name": "cis-SNARE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54JY7", "map_id": "Q54JY7", "name": "syn7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287733", "map_id": "DDB_G0287733", "name": "syn7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IJ1", "map_id": "Q54IJ1", "name": "scfd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288719", "map_id": "DDB_G0288719", "name": "scfd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710152", "map_id": "none", "name": "cis-SNARE:NSF hexamer:3xSNAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10710161", "map_id": "none", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10710064", "map_id": "none", "name": "TRAPPCII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YG5", "map_id": "Q54YG5", "name": "trappc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278643", "map_id": "DDB_G0278643", "name": "trappc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Z3", "map_id": "Q556Z3", "name": "trapcc10-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273209", "map_id": "DDB_G0273209", "name": "trapcc10-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CU7", "map_id": "Q54CU7", "name": "trappc2l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292690", "map_id": "DDB_G0292690", "name": "trappc2l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UU1", "map_id": "Q54UU1", "name": "trappc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280827", "map_id": "DDB_G0280827", "name": "trappc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555X3", "map_id": "Q555X3", "name": "TRAPPC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274803", "map_id": "DDB_G0274803", "name": "TRAPPC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TK7", "map_id": "Q54TK7", "name": "TRAPPC6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281693", "map_id": "DDB_G0281693", "name": "TRAPPC6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557G3", "map_id": "Q557G3", "name": "trappc1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273467", "map_id": "DDB_G0273467", "name": "trappc1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RV6", "map_id": "Q54RV6", "name": "trappc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282887", "map_id": "DDB_G0282887", "name": "trappc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K94", "map_id": "Q86K94", "name": "trappc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277135", "map_id": "DDB_G0277135", "name": "trappc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681311", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane", "complex": "true" }, { "id": "Q55CT5", "map_id": "Q55CT5", "name": "sec31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270992", "map_id": "DDB_G0270992", "name": "sec31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS8", "map_id": "Q54DS8", "name": "sec13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292052", "map_id": "DDB_G0292052", "name": "sec13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710066", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10710218", "map_id": "none", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10710176", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54C46", "map_id": "Q54C46", "name": "GORASP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293248", "map_id": "DDB_G0293248", "name": "GORASP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681091", "map_id": "none", "name": "SEC31A:SEC13:SEC23IP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710180", "map_id": "Q54T59", "name": "phospho-sec23", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710182", "map_id": "none", "name": "COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10710103", "map_id": "none", "name": "p-SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710210", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10710215", "map_id": "Q556Y4", "name": "cak1-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10715198", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10715134", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10715196", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10715136", "map_id": "none", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10715132", "map_id": "none", "name": "USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10716719", "map_id": "none", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10710157", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10710126", "map_id": "Q55FD0", "name": "GOSR2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10710131", "map_id": "Q54IJ1", "name": "scfd1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710140", "map_id": "none", "name": "STX5,17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10710124", "map_id": "Q54SJ2", "name": "BET1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10710148", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10710264", "map_id": "none", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10715205", "map_id": "none", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10715202", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10715260", "map_id": "none", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10715258", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10715820", "map_id": "none", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715816", "map_id": "none", "name": "cis-Golgi cis SNARE bundle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54QH2", "map_id": "Q54QH2", "name": "GOSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283831", "map_id": "DDB_G0283831", "name": "GOSR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715818", "map_id": "none", "name": "cis-SNARE:3xSNAP:NSF hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10710087", "map_id": "none", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681157", "map_id": "Q54Z72", "name": "sec24l", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681155", "map_id": "none", "name": "GOSR2,STX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10681163", "map_id": "none", "name": "SEC23A:SEC24C,D:GOSR2,STX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10681337", "map_id": "none", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681229", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BR0", "map_id": "Q55BR0", "name": "wimA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269198", "map_id": "DDB_G0269198", "name": "wimA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681104", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10681231", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10710159", "map_id": "none", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10681217", "map_id": "Q54VR1", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10681211", "map_id": "none", "name": "LMAN family receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10681219", "map_id": "none", "name": "LMAN receptor:glycosylated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10710073", "map_id": "none", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10710070", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10715814", "map_id": "none", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715791", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55BB8", "map_id": "Q55BB8", "name": "cog8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271388", "map_id": "DDB_G0271388", "name": "cog8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C87", "map_id": "Q54C87", "name": "COG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293106", "map_id": "DDB_G0293106", "name": "COG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HE0", "map_id": "Q54HE0", "name": "cog5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289535", "map_id": "DDB_G0289535", "name": "cog5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UC2", "map_id": "Q54UC2", "name": "cog2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281163", "map_id": "DDB_G0281163", "name": "cog2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YV5", "map_id": "Q54YV5", "name": "TMEM115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278061", "map_id": "DDB_G0278061", "name": "TMEM115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LC8", "map_id": "Q54LC8", "name": "cog7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286705", "map_id": "DDB_G0286705", "name": "cog7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TT4", "map_id": "Q54TT4", "name": "cog3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281511", "map_id": "DDB_G0281511", "name": "cog3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CT0", "map_id": "Q54CT0", "name": "cog6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292784", "map_id": "DDB_G0292784", "name": "cog6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZB3", "map_id": "Q54ZB3", "name": "cog1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277691", "map_id": "DDB_G0277691", "name": "cog1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715810", "map_id": "none", "name": "cis-Golgi t-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10715812", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10715823", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10715804", "map_id": "Q55FD0", "name": "GOSR2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10715796", "map_id": "Q54QH2", "name": "GOSR1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10715800", "map_id": "Q54ZH1", "name": "syn5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10715779", "map_id": "Q54SJ2", "name": "BET1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10715679", "map_id": "Q54BK5", "name": "PalmC-YKT6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10715798", "map_id": "Q54SJ2", "name": "BET1L", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10725871", "map_id": "none", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678991", "map_id": "LigandDisplayForward?ligandId=6784", "name": "tacrolimus", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677557", "map_id": "none", "name": "Homologues of FKBP1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UR2", "map_id": "Q54UR2", "name": "FKBP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280877", "map_id": "DDB_G0280877", "name": "FKBP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554J3", "map_id": "Q554J3", "name": "fkbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275227", "map_id": "DDB_G0275227", "name": "fkbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725869", "map_id": "none", "name": "FKBP1A:tacrolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689890", "map_id": "none", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10679153", "map_id": "none", "name": "p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10689887", "map_id": "none", "name": "p-RASGRP1,3:DAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724463", "map_id": "none", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10724456", "map_id": "Q54U56", "name": "DAPP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281265", "map_id": "DDB_G0281265", "name": "phospho-p-Y139-DAPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724461", "map_id": "none", "name": "p-Y139-DAPP1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54U56", "map_id": "Q54U56", "name": "phospho-p-Y139-DAPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676519", "map_id": "none", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10676517", "map_id": "Q869N1", "name": "cytC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10676515", "map_id": "Q869N1", "name": "cytC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675766", "map_id": "none", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672167", "map_id": "none", "name": "RNA Polymerase II (unphosphorylated):TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674774", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ND1", "map_id": "Q54ND1", "name": "gtf2a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285343", "map_id": "DDB_G0285343", "name": "gtf2a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DH8", "map_id": "Q54DH8", "name": "taf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292242", "map_id": "DDB_G0292242", "name": "taf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XM9", "map_id": "Q54XM9", "name": "taf11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278843", "map_id": "DDB_G0278843", "name": "taf11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26355", "map_id": "P26355", "name": "tbpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275617", "map_id": "DDB_G0275617", "name": "tbpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555L9", "map_id": "Q555L9", "name": "TAF12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274697", "map_id": "DDB_G0274697", "name": "TAF12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G80", "map_id": "Q54G80", "name": "gtf2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290327", "map_id": "DDB_G0290327", "name": "gtf2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KH7", "map_id": "Q54KH7", "name": "TAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287337", "map_id": "DDB_G0287337", "name": "TAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A39", "map_id": "Q55A39", "name": "TAF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272360", "map_id": "DDB_G0272360", "name": "TAF9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CN8", "map_id": "Q54CN8", "name": "taf13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292838", "map_id": "DDB_G0292838", "name": "taf13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IW7", "map_id": "Q54IW7", "name": "TAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288471", "map_id": "DDB_G0288471", "name": "TAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X70", "map_id": "Q54X70", "name": "TAF4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279179", "map_id": "DDB_G0279179", "name": "TAF4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FD6", "map_id": "Q54FD6", "name": "gtf2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290929", "map_id": "DDB_G0290929", "name": "gtf2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G081", "map_id": "C7G081", "name": "taf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292724", "map_id": "DDB_G0292724", "name": "taf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BH6", "map_id": "Q55BH6", "name": "TAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271338", "map_id": "DDB_G0271338", "name": "TAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674776", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675764", "map_id": "none", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674115", "map_id": "Q54FD6", "name": "gtf2b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10674110", "map_id": "none", "name": "TFIIA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674772", "map_id": "none", "name": "pol II promoter:TFIID complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675762", "map_id": "none", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109627", "map_id": "none", "name": "DNA containing RNA Polymerase II promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10674181", "map_id": "none", "name": "TFIID", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675768", "map_id": "none", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10673970", "map_id": "none", "name": "TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674778", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KJ8", "map_id": "Q54KJ8", "name": "gtf2e2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287307", "map_id": "DDB_G0287307", "name": "gtf2e2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557M8", "map_id": "Q557M8", "name": "gtf2e1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273525", "map_id": "DDB_G0273525", "name": "gtf2e1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674870", "map_id": "none", "name": "pol II closed pre-initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674780", "map_id": "none", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674193", "map_id": "none", "name": "TFIIE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675912", "map_id": "none", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675909", "map_id": "none", "name": "UNG-1:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P53766", "map_id": "P53766", "name": "uglA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277877", "map_id": "DDB_G0277877", "name": "uglA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675902", "map_id": "none", "name": "UNG-1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675921", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675916", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86K43", "map_id": "Q86K43", "name": "NTH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277247", "map_id": "DDB_G0277247", "name": "NTH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10675918", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675942", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675939", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675905", "map_id": "none", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675898", "map_id": "none", "name": "UNG-1:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10675961", "map_id": "none", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675958", "map_id": "none", "name": "OGG1:FapyG-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CZ3", "map_id": "Q54CZ3", "name": "OGG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292618", "map_id": "DDB_G0292618", "name": "OGG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675953", "map_id": "none", "name": "OGG1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5636006", "map_id": "CHEBI:29145", "name": "FapyG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675935", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675932", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675928", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675925", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10699054", "map_id": "none", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10699051", "map_id": "none", "name": "SOD3 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54TU5", "map_id": "Q54TU5", "name": "sodD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281493", "map_id": "DDB_G0281493", "name": "sodD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G70", "map_id": "Q54G70", "name": "sodE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290343", "map_id": "DDB_G0290343", "name": "sodE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F73", "map_id": "Q54F73", "name": "ccs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291031", "map_id": "DDB_G0291031", "name": "ccs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TW8", "map_id": "Q54TW8", "name": "sodF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281461", "map_id": "DDB_G0281461", "name": "sodF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RN1", "map_id": "Q54RN1", "name": "sodB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283021", "map_id": "DDB_G0283021", "name": "sodB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RQ1", "map_id": "Q54RQ1", "name": "sodC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282993", "map_id": "DDB_G0282993", "name": "sodC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_936901", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10699338", "map_id": "none", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699335", "map_id": "none", "name": "PRDX6:GSTP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54SE2", "map_id": "Q54SE2", "name": "PRDX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282517", "map_id": "DDB_G0282517", "name": "PRDX6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699064", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699061", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10675004", "map_id": "none", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10675001", "map_id": "none", "name": "CAT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O77229", "map_id": "O77229", "name": "catA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274595", "map_id": "DDB_G0274595", "name": "catA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5623644", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10699781", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222481", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1222379", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10699323", "map_id": "Q54N76", "name": "PRDX5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10699292", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10699289", "map_id": "none", "name": "PRDX3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W09", "map_id": "Q54W09", "name": "PRDX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279973", "map_id": "DDB_G0279973", "name": "PRDX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699784", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3697881", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3697842", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10699287", "map_id": "Q54N76", "name": "PRDX5-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10715116", "map_id": "none", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10715113", "map_id": "none", "name": "NOX4, NOX5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10699307", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10699937", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10699934", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "reaction_10698995", "map_id": "none", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3299683", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10698992", "map_id": "none", "name": "SOD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55BJ9", "map_id": "Q55BJ9", "name": "sod2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271106", "map_id": "DDB_G0271106", "name": "sod2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700993", "map_id": "none", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10700991", "map_id": "none", "name": "SOD3 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10699301", "map_id": "none", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1655882", "map_id": "CHEBI:17858", "name": "GSSG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10699298", "map_id": "none", "name": "GSR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10697280", "map_id": "none", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131972", "map_id": "CHEBI:57967", "name": "ADP-D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78346", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10697277", "map_id": "none", "name": "NUDT5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S89", "map_id": "Q54S89", "name": "NUDT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282603", "map_id": "DDB_G0282603", "name": "NUDT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670550", "map_id": "none", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670546", "map_id": "none", "name": "RFC Heteropentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54E21", "map_id": "Q54E21", "name": "rfc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291868", "map_id": "DDB_G0291868", "name": "rfc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST4", "map_id": "Q54ST4", "name": "rfc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282235", "map_id": "DDB_G0282235", "name": "rfc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MH9", "map_id": "Q54MH9", "name": "rfc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285961", "map_id": "DDB_G0285961", "name": "rfc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MD4", "map_id": "Q54MD4", "name": "rfc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286027", "map_id": "DDB_G0286027", "name": "rfc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BN3", "map_id": "Q54BN3", "name": "rfc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293702", "map_id": "DDB_G0293702", "name": "rfc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670361", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670548", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670588", "map_id": "none", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670563", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex:PCNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670565", "map_id": "none", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670559", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670561", "map_id": "none", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10716868", "map_id": "none", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716859", "map_id": "none", "name": "ARF1:GTP:CYTH1,2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716865", "map_id": "none", "name": "ARF1:GDP:CYTH1,2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10717007", "map_id": "none", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10717003", "map_id": "none", "name": "other COG-interacting RABs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55FK2", "map_id": "Q55FK2", "name": "rab6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268068", "map_id": "DDB_G0268068", "name": "rab6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG2", "map_id": "Q1ZXG2", "name": "GGC-RAB30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294577", "map_id": "DDB_G0294577", "name": "GGC-RAB30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10715666", "map_id": "none", "name": "COG complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10717005", "map_id": "none", "name": "COG complex:RABs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716805", "map_id": "none", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10693010", "map_id": "none", "name": "ARF1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716801", "map_id": "none", "name": "TRIP11:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "Q55BL9", "map_id": "Q55BL9", "name": "TRIP11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0346831", "map_id": "DDB_G0346831", "name": "TRIP11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716803", "map_id": "none", "name": "ARF1:GTP:TRIP11:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716884", "map_id": "none", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716880", "map_id": "none", "name": "RIC1:RGP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q76NU4", "map_id": "Q76NU4", "name": "DG1122", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277397", "map_id": "DDB_G0277397", "name": "DG1122", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WR7", "map_id": "Q54WR7", "name": "RIC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279477", "map_id": "DDB_G0279477", "name": "RIC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716874", "map_id": "none", "name": "RAB33B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O76173", "map_id": "O76173", "name": "Rab1C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269174", "map_id": "DDB_G0269174", "name": "Rab1C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716882", "map_id": "none", "name": "RAB33B:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716861", "map_id": "none", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716831", "map_id": "none", "name": "CYTH1,2,3,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10716313", "map_id": "none", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716309", "map_id": "none", "name": "other COG interacting snares", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54R67", "map_id": "Q54R67", "name": "VTI1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283363", "map_id": "DDB_G0283363", "name": "VTI1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ5", "map_id": "Q54PQ5", "name": "STX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284385", "map_id": "DDB_G0284385", "name": "STX6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CK6", "map_id": "Q54CK6", "name": "vti1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292974", "map_id": "DDB_G0292974", "name": "vti1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW2", "map_id": "Q54PW2", "name": "syn6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284185", "map_id": "DDB_G0284185", "name": "syn6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GE3", "map_id": "Q54GE3", "name": "vps45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290213", "map_id": "DDB_G0290213", "name": "vps45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551H5", "map_id": "Q551H5", "name": "STX16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276575", "map_id": "DDB_G0276575", "name": "STX16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716311", "map_id": "none", "name": "COG complex:Golgi snares", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716784", "map_id": "none", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10716780", "map_id": "none", "name": "STX:PalmC-YKT6:BET1L:GOSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10716782", "map_id": "none", "name": "STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10716787", "map_id": "none", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10709489", "map_id": "none", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709484", "map_id": "none", "name": "UCHL1,UCHL3:Ub-Lys", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1131871", "map_id": "CHEBI:32551", "name": "L-lysine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10709486", "map_id": "none", "name": "UCHL1,UCHL3:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703500", "map_id": "none", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703441", "map_id": "Q556N5", "name": "adrm1-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272624", "map_id": "DDB_G0272624", "name": "adrm1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703443", "map_id": "none", "name": "ADRM1:26S proteasome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556N5", "map_id": "Q556N5", "name": "adrm1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703447", "map_id": "none", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703436", "map_id": "Q54N38", "name": "uch2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285527", "map_id": "DDB_G0285527", "name": "uch2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703445", "map_id": "none", "name": "ADRM1:26S proteasome:UCHL5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N38", "map_id": "Q54N38", "name": "uch2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717861", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717713", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717709", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10702140", "map_id": "none", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702129", "map_id": "P15112", "name": "efbA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702132", "map_id": "P15112", "name": "efbA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702137", "map_id": "Q75JG8", "name": "dph5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0276115", "map_id": "DDB_G0276115", "name": "dph5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700403", "map_id": "none", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696675", "map_id": "none", "name": "Homologues of PARP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8I7C6", "map_id": "Q8I7C6", "name": "adprt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292820", "map_id": "DDB_G0292820", "name": "adprt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GU8", "map_id": "Q55GU8", "name": "adprt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267468", "map_id": "DDB_G0267468", "name": "adprt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X55", "map_id": "Q54X55", "name": "adprt1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279195", "map_id": "DDB_G0279195", "name": "adprt1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HY5", "map_id": "Q54HY5", "name": "PAR-PARP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289141", "map_id": "DDB_G0289141", "name": "PAR-PARP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XI2", "map_id": "Q54XI2", "name": "adprt1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278741", "map_id": "DDB_G0278741", "name": "adprt1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700401", "map_id": "none", "name": "2SUMO1:PARP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698387", "map_id": "none", "name": "Homologues of PIAS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10673665", "map_id": "none", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673661", "map_id": "none", "name": "40S:eIF3:eIF1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54EQ1", "map_id": "Q54EQ1", "name": "eif3K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291404", "map_id": "DDB_G0291404", "name": "eif3K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KZ8", "map_id": "Q54KZ8", "name": "eif3m", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287005", "map_id": "DDB_G0287005", "name": "eif3m", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KI0", "map_id": "Q54KI0", "name": "eif3J", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287333", "map_id": "DDB_G0287333", "name": "eif3J", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MT0", "map_id": "Q54MT0", "name": "eif3I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285683", "map_id": "DDB_G0285683", "name": "eif3I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW1", "map_id": "Q54QW1", "name": "eif3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283597", "map_id": "DDB_G0283597", "name": "eif3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CC5", "map_id": "Q54CC5", "name": "eif3E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293052", "map_id": "DDB_G0293052", "name": "eif3E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X97", "map_id": "Q54X97", "name": "eif3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279109", "map_id": "DDB_G0279109", "name": "eif3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UD0", "map_id": "Q54UD0", "name": "eif3H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281153", "map_id": "DDB_G0281153", "name": "eif3H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554U9", "map_id": "Q554U9", "name": "eif3d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274627", "map_id": "DDB_G0274627", "name": "eif3d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C49", "map_id": "Q54C49", "name": "eif3f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293254", "map_id": "DDB_G0293254", "name": "eif3f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YJ6", "map_id": "Q54YJ6", "name": "eif1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278205", "map_id": "DDB_G0278205", "name": "eif1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B20", "map_id": "Q86B20", "name": "eif3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272078", "map_id": "DDB_G0272078", "name": "eif3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LA2", "map_id": "Q86LA2", "name": "eif3L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272076", "map_id": "DDB_G0272076", "name": "eif3L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673298", "map_id": "none", "name": "ternary complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673300", "map_id": "none", "name": "43S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10687107", "map_id": "none", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10686806", "map_id": "none", "name": "Homologues of PDIA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54BW3", "map_id": "Q54BW3", "name": "PDIA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293378", "map_id": "DDB_G0293378", "name": "PDIA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EN4", "map_id": "Q54EN4", "name": "pdi2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291434", "map_id": "DDB_G0291434", "name": "pdi2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687103", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q23858", "map_id": "Q23858", "name": "crtA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283539", "map_id": "DDB_G0283539", "name": "crtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BA8", "map_id": "Q55BA8", "name": "cnxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271144", "map_id": "DDB_G0271144", "name": "cnxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687105", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10700206", "map_id": "none", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10684083", "map_id": "Q54UJ3", "name": "SIN3A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281045", "map_id": "DDB_G0281045", "name": "SUMO1-SIN3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700198", "map_id": "none", "name": "SUMO1:SIN3A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UJ3", "map_id": "Q54UJ3", "name": "SUMO1-SIN3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700203", "map_id": "Q54UA7", "name": "TOPORS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281183", "map_id": "DDB_G0281183", "name": "SUMO1-K560-TOPORS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700515", "map_id": "none", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700491", "map_id": "Q54YJ7", "name": "xrcc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700504", "map_id": "none", "name": "SUMO1:XRCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700512", "map_id": "none", "name": "PIAS1,2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705691", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10705524", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "Q54WE0", "map_id": "Q54WE0", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292508", "map_id": "DDB_G0292508", "name": "SFTPB(25-200)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PT7", "map_id": "Q54PT7", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SX7", "map_id": "Q54SX7", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C60", "map_id": "Q54C60", "name": "sapA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293010", "map_id": "DDB_G0293010", "name": "sapA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q68", "map_id": "Q54Q68", "name": "sapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284043", "map_id": "DDB_G0284043", "name": "sapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LG2", "map_id": "Q54LG2", "name": "salA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286561", "map_id": "DDB_G0286561", "name": "salA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WE4", "map_id": "Q54WE4", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LG1", "map_id": "Q54LG1", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C30", "map_id": "Q55C30", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D30", "map_id": "Q54D30", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LG3", "map_id": "Q54LG3", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KA8", "map_id": "Q86KA8", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F52", "map_id": "Q54F52", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75K05", "map_id": "Q75K05", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10705620", "map_id": "none", "name": "Homologues of SFTPB(280-381)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10705588", "map_id": "none", "name": "Homologues of SFTPB(25-200)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10705556", "map_id": "none", "name": "Homologues of SFTPB(201-279)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10705688", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10683855", "map_id": "none", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683798", "map_id": "Q6B516", "name": "sgkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683851", "map_id": "none", "name": "CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55D95", "map_id": "Q55D95", "name": "CCT6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269736", "map_id": "DDB_G0269736", "name": "CCT6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BM4", "map_id": "Q55BM4", "name": "tcp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269190", "map_id": "DDB_G0269190", "name": "tcp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552J0", "map_id": "Q552J0", "name": "cct8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276233", "map_id": "DDB_G0276233", "name": "cct8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CL2", "map_id": "Q54CL2", "name": "cct4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292872", "map_id": "DDB_G0292872", "name": "cct4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TD3", "map_id": "Q54TD3", "name": "cct5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281849", "map_id": "DDB_G0281849", "name": "cct5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TH8", "map_id": "Q54TH8", "name": "cct3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281741", "map_id": "DDB_G0281741", "name": "cct3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683853", "map_id": "none", "name": "CCT/TRiC:ADP:Sphingosine kinase 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10673340", "map_id": "none", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673329", "map_id": "none", "name": "48S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_72617", "map_id": "none", "name": "eIF1", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10684883", "map_id": "none", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_428040", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428639", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428633", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684880", "map_id": "Q54W37", "name": "SLC17A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0280761", "map_id": "DDB_G0280761", "name": "SLC17A3(1-498)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685907", "map_id": "none", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_449703", "map_id": "CHEBI:15784", "name": "AcGlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10685904", "map_id": "none", "name": "2xGNPNAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WR8", "map_id": "Q54WR8", "name": "gna1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279475", "map_id": "DDB_G0279475", "name": "gna1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709063", "map_id": "none", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10707630", "map_id": "none", "name": "USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q869U4", "map_id": "Q869U4", "name": "USP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276443", "map_id": "DDB_G0276443", "name": "USP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709060", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10707644", "map_id": "none", "name": "USP7:TP53,MDM2,MDM4,FOXO4,PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685919", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10685916", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54PV8", "map_id": "Q54PV8", "name": "ppa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284265", "map_id": "DDB_G0284265", "name": "ppa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10676992", "map_id": "none", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676983", "map_id": "none", "name": "eEF1B complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GRF8", "map_id": "Q9GRF8", "name": "efa1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284035", "map_id": "DDB_G0284035", "name": "efa1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G141", "map_id": "B0G141", "name": "efa1G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282979", "map_id": "DDB_G0282979", "name": "efa1G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676987", "map_id": "none", "name": "eEF1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10676969", "map_id": "none", "name": "eEF1A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10676989", "map_id": "none", "name": "eEF1B:GDP exchange complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724695", "map_id": "none", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10724693", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10682226", "map_id": "none", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682212", "map_id": "Q54NV1", "name": "exoc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285067", "map_id": "DDB_G0285067", "name": "exoc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682207", "map_id": "Q54VZ8", "name": "exoc8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0279991", "map_id": "DDB_G0279991", "name": "exoc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682222", "map_id": "Q558Z9", "name": "exoc7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0272991", "map_id": "DDB_G0272991", "name": "exoc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682192", "map_id": "Q54VX5", "name": "exoc2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0280081", "map_id": "DDB_G0280081", "name": "exoc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682187", "map_id": "Q54P76", "name": "exoc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0284833", "map_id": "DDB_G0284833", "name": "exoc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682217", "map_id": "Q54BP6", "name": "exoc3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "DDB_G0293520", "map_id": "DDB_G0293520", "name": "exoc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682197", "map_id": "B0G163", "name": "exoc5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287881", "map_id": "DDB_G0287881", "name": "exoc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682202", "map_id": "Q54B27", "name": "exoc6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0293936", "map_id": "DDB_G0293936", "name": "exoc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682224", "map_id": "none", "name": "Exocyst Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54BP6", "map_id": "Q54BP6", "name": "exoc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX5", "map_id": "Q54VX5", "name": "exoc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q558Z9", "map_id": "Q558Z9", "name": "exoc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VZ8", "map_id": "Q54VZ8", "name": "exoc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NV1", "map_id": "Q54NV1", "name": "exoc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G163", "map_id": "B0G163", "name": "exoc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P76", "map_id": "Q54P76", "name": "exoc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B27", "map_id": "Q54B27", "name": "exoc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710630", "map_id": "none", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710625", "map_id": "none", "name": "USP44:PolyUb-CDC20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55EJ1", "map_id": "Q55EJ1", "name": "USP44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268872", "map_id": "DDB_G0268872", "name": "USP44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710627", "map_id": "none", "name": "USP44:CDC20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698407", "map_id": "none", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698360", "map_id": "Q54C05", "name": "BRCA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293300", "map_id": "DDB_G0293300", "name": "SUMO2,3-BRCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698405", "map_id": "none", "name": "SUMO1:BRCA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C05", "map_id": "Q54C05", "name": "SUMO2,3-BRCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698389", "map_id": "none", "name": "PIAS1,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710874", "map_id": "none", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710869", "map_id": "none", "name": "USP17:K63polyUb-SUDS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LI3", "map_id": "Q54LI3", "name": "K63polyUb-SUDS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286805", "map_id": "DDB_G0286805", "name": "K63polyUb-SUDS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PU3", "map_id": "Q54PU3", "name": "K63polyUb-SUDS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J16", "map_id": "Q86J16", "name": "USP17L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274827", "map_id": "DDB_G0274827", "name": "USP17L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10708452", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710871", "map_id": "none", "name": "USP17:SUDS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10686727", "map_id": "none", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532562", "map_id": "CHEBI:17369", "name": "Man6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686724", "map_id": "Q54PA0", "name": "mpi", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284685", "map_id": "DDB_G0284685", "name": "mpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711136", "map_id": "none", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787618", "map_id": "CHEBI:16955", "name": "GDP-DHDMan", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711133", "map_id": "Q1ZXF7", "name": "gmd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284553", "map_id": "DDB_G0284553", "name": "gmd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722373", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10722365", "map_id": "none", "name": "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54C55", "map_id": "Q54C55", "name": "pex14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293264", "map_id": "DDB_G0293264", "name": "pex14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S31", "map_id": "Q54S31", "name": "pex10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282693", "map_id": "DDB_G0282693", "name": "pex10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CL3", "map_id": "Q54CL3", "name": "pex13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292870", "map_id": "DDB_G0292870", "name": "pex13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N40", "map_id": "Q54N40", "name": "pex12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285523", "map_id": "DDB_G0285523", "name": "pex12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722369", "map_id": "none", "name": "Ub:UBE2D1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722371", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10711128", "map_id": "none", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787646", "map_id": "CHEBI:86476", "name": "GDP-KDGal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711125", "map_id": "none", "name": "TSTA3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55C77", "map_id": "Q55C77", "name": "ger", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270184", "map_id": "DDB_G0270184", "name": "ger", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687947", "map_id": "none", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687940", "map_id": "Q86L44", "name": "helF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687942", "map_id": "Q86L44", "name": "helF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687944", "map_id": "Q54ZW5", "name": "rps3a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673351", "map_id": "none", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673316", "map_id": "Q55FE0", "name": "eif4e", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673311", "map_id": "none", "name": "eIF4A subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673321", "map_id": "Q553R3", "name": "eif4g", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673323", "map_id": "none", "name": "eIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10702162", "map_id": "none", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702142", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353106", "map_id": "CHEBI:17509", "name": "MTAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702159", "map_id": "none", "name": "DPH1:DPH2:DPH3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0G132", "map_id": "B0G132", "name": "dph2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295687", "map_id": "DDB_G0295687", "name": "dph2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW5", "map_id": "Q54PW5", "name": "dph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284257", "map_id": "DDB_G0284257", "name": "dph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWL8", "map_id": "Q7KWL8", "name": "DPH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277061", "map_id": "DDB_G0277061", "name": "DPH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673659", "map_id": "none", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673277", "map_id": "Q54YJ6", "name": "eif1a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673640", "map_id": "none", "name": "80S ribosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MG6", "map_id": "Q54MG6", "name": "rpl37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285971", "map_id": "DDB_G0285971", "name": "rpl37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L05", "map_id": "Q86L05", "name": "rpl10a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276871", "map_id": "DDB_G0276871", "name": "rpl10a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM8", "map_id": "Q54QM8", "name": "rpl26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283741", "map_id": "DDB_G0283741", "name": "rpl26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GS21", "map_id": "Q9GS21", "name": "rpl28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": 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"type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TW3", "map_id": "Q54TW3", "name": "rpl29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281469", "map_id": "DDB_G0281469", "name": "rpl29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D63", "map_id": "Q54D63", "name": "rpl6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292460", "map_id": "DDB_G0292460", "name": "rpl6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE3", "map_id": "Q54JE3", "name": "rpl22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288101", "map_id": "DDB_G0288101", "name": "rpl22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553M7", "map_id": "Q553M7", "name": "rpl13a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275881", "map_id": "DDB_G0275881", "name": "rpl13a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z09", "map_id": "Q54Z09", "name": "rpl14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277975", "map_id": "DDB_G0277975", "name": "rpl14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22685", "map_id": "P22685", "name": "rplp0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286501", "map_id": "DDB_G0286501", "name": "rplp0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22684", "map_id": "P22684", "name": "rplp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277907", "map_id": "DDB_G0277907", "name": "rplp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VZ4", "map_id": "Q54VZ4", "name": "rpl18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279997", "map_id": "DDB_G0279997", "name": "rpl18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BN7", "map_id": "Q55BN7", "name": "rpl35a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270424", "map_id": "DDB_G0270424", "name": "rpl35a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BE6", "map_id": "Q55BE6", "name": "rpl27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271298", "map_id": "DDB_G0271298", "name": "rpl27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AB5", "map_id": "Q55AB5", "name": "rpl32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271976", "map_id": "DDB_G0271976", "name": "rpl32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K01", "map_id": "Q86K01", "name": "rpl15-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272893", "map_id": "DDB_G0272893", "name": "rpl15-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BS9", "map_id": "Q55BS9", "name": "rpl30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270380", "map_id": "DDB_G0270380", "name": "rpl30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J23", "map_id": "Q54J23", "name": "rpl35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288349", "map_id": "DDB_G0288349", "name": "rpl35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11874", "map_id": "P11874", "name": "rpl7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276441", "map_id": "DDB_G0276441", "name": "rpl7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XX3", "map_id": "Q54XX3", "name": "rpl5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278539", "map_id": "DDB_G0278539", "name": "rpl5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GJ7", "map_id": "Q55GJ7", "name": "rpl38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268302", "map_id": "DDB_G0268302", "name": "rpl38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X53", "map_id": "Q54X53", "name": "rpl21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279387", "map_id": "DDB_G0279387", "name": "rpl21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G051", "map_id": "C7G051", "name": "rpl39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0302511", "map_id": "DDB_G0302511", "name": "rpl39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BQ3", "map_id": "Q54BQ3", "name": "rpl23a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293502", "map_id": "DDB_G0293502", "name": "rpl23a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VN6", "map_id": "Q54VN6", "name": "rpl24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280229", "map_id": "DDB_G0280229", "name": "rpl24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G86", "map_id": "Q54G86", "name": "rpl23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290315", "map_id": "DDB_G0290315", "name": "rpl23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J69", "map_id": "Q54J69", "name": "rpl10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288273", "map_id": "DDB_G0288273", "name": "rpl10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GK6", "map_id": "Q54GK6", "name": "rpl22a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290091", "map_id": "DDB_G0290091", "name": "rpl22a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG2", "map_id": "Q54NG2", "name": "rpl17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285277", "map_id": "DDB_G0285277", "name": "rpl17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16168", "map_id": "P16168", "name": "rpl11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279189", "map_id": "DDB_G0279189", "name": "rpl11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34113", "map_id": "P34113", "name": "rpl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291862", "map_id": "DDB_G0291862", "name": "rpl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22683", "map_id": "P22683", "name": "rplp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283393", "map_id": "DDB_G0283393", "name": "rplp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E20", "map_id": "Q54E20", "name": "rpl13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291870", "map_id": "DDB_G0291870", "name": "rpl13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13023", "map_id": "P13023", "name": "rpl8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274113", "map_id": "DDB_G0274113", "name": "rpl8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48160", "map_id": "P48160", "name": "rpl27a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292388", "map_id": "DDB_G0292388", "name": "rpl27a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CW5", "map_id": "Q55CW5", "name": "rpl36a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270984", "map_id": "DDB_G0270984", "name": "rpl36a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XB5", "map_id": "Q54XB5", "name": "rpl31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279061", "map_id": "DDB_G0279061", "name": "rpl31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14329", "map_id": "P14329", "name": "rpl19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281565", "map_id": "DDB_G0281565", "name": "rpl19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZD1", "map_id": "Q54ZD1", "name": "rpl7a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277629", "map_id": "DDB_G0277629", "name": "rpl7a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673638", "map_id": "none", "name": "60S ribosomal complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10709775", "map_id": "none", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2022135", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83921", "map_id": "CHEBI:17596", "name": "Ino", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10709772", "map_id": "none", "name": "CECR1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q553U5", "map_id": "Q553U5", "name": "ADA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275179", "map_id": "DDB_G0275179", "name": "ADA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722383", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10690046", "map_id": "none", "name": "UBE2D1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10722380", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10673655", "map_id": "none", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673649", "map_id": "none", "name": "80S:Met-tRNAi:mRNA:eIF5B:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XP6", "map_id": "Q54XP6", "name": "eif5b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278815", "map_id": "DDB_G0278815", "name": "eif5b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673651", "map_id": "none", "name": "eIF5B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673653", "map_id": "none", "name": "80S:Met-tRNAi:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677197", "map_id": "none", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855656", "map_id": "CHEBI:53059", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449229", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855664", "map_id": "none", "name": "mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677194", "map_id": "Q1ZXB4", "name": "smp3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0291660", "map_id": "DDB_G0291660", "name": "smp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681359", "map_id": "none", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681343", "map_id": "P13651", "name": "eif5a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284861", "map_id": "DDB_G0284861", "name": "eif5a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681347", "map_id": "P13651", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681356", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MQ7", "map_id": "Q54MQ7", "name": "dhps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285725", "map_id": "DDB_G0285725", "name": "dhps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688493", "map_id": "none", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_981613", "map_id": "none", "name": "Glycoprotein with bifurcating GlcNAc in position 3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10688490", "map_id": "Q559V4", "name": "gnt7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0272422", "map_id": "DDB_G0272422", "name": "gnt7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717967", "map_id": "none", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717965", "map_id": "none", "name": "Homologues of UBB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10669997", "map_id": "none", "name": "Homologues of UBB(77-152)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10669975", "map_id": "none", "name": "Homologues of RPS27A(1-76)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670019", "map_id": "none", "name": "Homologues of UBB(153-228)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10709116", "map_id": "P54201", "name": "ubpA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0291239", "map_id": "DDB_G0291239", "name": "ubpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702126", "map_id": "none", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702118", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702123", "map_id": "Q54Y82", "name": "DPH6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278373", "map_id": "DDB_G0278373", "name": "DPH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698428", "map_id": "none", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698412", "map_id": "Q54LN0", "name": "TP53BP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286539", "map_id": "DDB_G0286539", "name": "TP53BP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698425", "map_id": "none", "name": "SUMO1:TP53BP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LN0", "map_id": "Q54LN0", "name": "TP53BP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716428", "map_id": "none", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682961", "map_id": "P36408", "name": "gpbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277143", "map_id": "DDB_G0277143", "name": "gpbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716426", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P36408", "map_id": "P36408", "name": "gpbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721435", "map_id": "none", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721415", "map_id": "Q54UC0", "name": "dnapkcs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721431", "map_id": "none", "name": "Ub:UBE2L3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721429", "map_id": "none", "name": "Homologues of RNF144A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10721433", "map_id": "none", "name": "RNF144A:PRKDC:Ub:UBE2L3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677189", "map_id": "none", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855660", "map_id": "CHEBI:77364", "name": "(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677186", "map_id": "none", "name": "PIGF:PIGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54PB0", "map_id": "Q54PB0", "name": "PIGF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284667", "map_id": "DDB_G0284667", "name": "PIGF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551Y7", "map_id": "Q551Y7", "name": "PIGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276251", "map_id": "DDB_G0276251", "name": "PIGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721463", "map_id": "none", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721452", "map_id": "none", "name": "RNF152:RRAGA:GDP:Ub:UBE2N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10721450", "map_id": "none", "name": "Ub:UBE2N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721443", "map_id": "Q54L05", "name": "RNF152", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10721460", "map_id": "none", "name": "K63polyUb-K142,K220,K230,K244-RRAGA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680834", "map_id": "Q86K32", "name": "ube2n", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10700718", "map_id": "none", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670555", "map_id": "Q54K47", "name": "pcna", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700716", "map_id": "none", "name": "SUMO1:PCNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721734", "map_id": "none", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721712", "map_id": "none", "name": "Ub:UBE2N:UBE2V2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10721731", "map_id": "none", "name": "HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54XR0", "map_id": "Q54XR0", "name": "rad18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278935", "map_id": "DDB_G0278935", "name": "rad18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G105", "map_id": "B0G105", "name": "HLTF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272082", "map_id": "DDB_G0272082", "name": "HLTF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721719", "map_id": "none", "name": "K63polyUb-K164-PCNA homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705259", "map_id": "none", "name": "UBE2N:UBE2V2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10721729", "map_id": "B0G105", "name": "HLTF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10721706", "map_id": "none", "name": "RAD18:UBE2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700659", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700639", "map_id": "Q86IG6", "name": "MDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0272690", "map_id": "DDB_G0272690", "name": "MDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700657", "map_id": "none", "name": "SUMO1:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86IG6", "map_id": "Q86IG6", "name": "MDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685756", "map_id": "none", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532204", "map_id": "CHEBI:7125", "name": "AcGlcN1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29494", "map_id": "CHEBI:46398", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_162756", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10685753", "map_id": "none", "name": "2xUAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GN5", "map_id": "Q54GN5", "name": "uap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290055", "map_id": "DDB_G0290055", "name": "uap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685711", "map_id": "none", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449312", "map_id": "CHEBI:59088", "name": "(GlcNAc)2 (Man)7 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449311", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449365", "map_id": "CHEBI:59091", "name": "(GlcNAc)2 (Man)8 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685708", "map_id": "Q55FZ9", "name": "alg12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0267884", "map_id": "DDB_G0267884", "name": "alg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685676", "map_id": "B0G0Z6", "name": "mpdu1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0295677", "map_id": "DDB_G0295677", "name": "mpdu1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10719651", "map_id": "none", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719273", "map_id": "none", "name": "RABGGTA:RABGGTB:CHMs:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1131164", "map_id": "CHEBI:48861", "name": "geranylgeranyl diphosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10719647", "map_id": "none", "name": "RABs:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DA7", "map_id": "Q54DA7", "name": "rab4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292406", "map_id": "DDB_G0292406", "name": "rab4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20790", "map_id": "P20790", "name": "rab8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280043", "map_id": "DDB_G0280043", "name": "rab8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36412", "map_id": "P36412", "name": "rab11A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269238", "map_id": "DDB_G0269238", "name": "rab11A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34142", "map_id": "P34142", "name": "rab21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286553", "map_id": "DDB_G0286553", "name": "rab21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20791", "map_id": "P20791", "name": "rab8B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276399", "map_id": "DDB_G0276399", "name": "rab8B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXQ2", "map_id": "Q8MXQ2", "name": "rab32C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275675", "map_id": "DDB_G0275675", "name": "rab32C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JP0", "map_id": "Q86JP0", "name": "GGC-RAB2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294583", "map_id": "DDB_G0294583", "name": "GGC-RAB2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36410", "map_id": "P36410", "name": "rab14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281337", "map_id": "DDB_G0281337", "name": "rab14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYF2", "map_id": "Q8MYF2", "name": "rabJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277441", "map_id": "DDB_G0277441", "name": "rabJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXK9", "map_id": "Q1ZXK9", "name": "GGC-RAB20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276007", "map_id": "DDB_G0276007", "name": "GGC-RAB20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G48", "map_id": "Q54G48", "name": "rabO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290407", "map_id": "DDB_G0290407", "name": "rabO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36409", "map_id": "P36409", "name": "rab2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292268", "map_id": "DDB_G0292268", "name": "rab2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RY4", "map_id": "Q54RY4", "name": "rabV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282899", "map_id": "DDB_G0282899", "name": "rabV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR3", "map_id": "Q54QR3", "name": "rab32A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283603", "map_id": "DDB_G0283603", "name": "rab32A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JP3", "map_id": "Q86JP3", "name": "rab5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271984", "map_id": "DDB_G0271984", "name": "rab5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ET3", "map_id": "Q55ET3", "name": "rabQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268760", "map_id": "DDB_G0268760", "name": "rabQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559X6", "map_id": "Q559X6", "name": "rab2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272138", "map_id": "DDB_G0272138", "name": "rab2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE7", "map_id": "Q1ZXE7", "name": "rabZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286169", "map_id": "DDB_G0286169", "name": "rabZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10719649", "map_id": "none", "name": "RGGT:CHMs:RABs:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10711110", "map_id": "none", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787542", "map_id": "CHEBI:12387", "name": "Fuc1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711107", "map_id": "Q54NH4", "name": "FPGT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285257", "map_id": "DDB_G0285257", "name": "FPGT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700169", "map_id": "none", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700167", "map_id": "none", "name": "SUMO1:K14-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10707595", "map_id": "none", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10707592", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10706130", "map_id": "none", "name": "Homologues of polyUb-PARK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10711231", "map_id": "none", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6788753", "map_id": "CHEBI:86019", "name": "S-FARN-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788758", "map_id": "CHEBI:87167", "name": "S-FARN-CME", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711228", "map_id": "none", "name": "ICMT:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q558K8", "map_id": "Q558K8", "name": "icmt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272799", "map_id": "DDB_G0272799", "name": "icmt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717943", "map_id": "none", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717940", "map_id": "none", "name": "Homologues of UBC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670107", "map_id": "none", "name": "Homologues of UBC(457-532)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670151", "map_id": "none", "name": "Homologues of UBC(609-684)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670085", "map_id": "none", "name": "Homologues of UBC(381-456)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670063", "map_id": "none", "name": "Homologues of UBC(305-380)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670041", "map_id": "none", "name": "Homologues of UBC(229-304)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670129", "map_id": "none", "name": "Homologues of UBC(533-608)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10672012", "map_id": "none", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10672009", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10717761", "map_id": "none", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717711", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717707", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717759", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685772", "map_id": "none", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29410", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110096", "map_id": "CHEBI:58223", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_532214", "map_id": "CHEBI:15812", "name": "DbGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685769", "map_id": "Q54J42", "name": "alg5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0288321", "map_id": "DDB_G0288321", "name": "alg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685897", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685894", "map_id": "none", "name": "GFPT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LK1", "map_id": "Q54LK1", "name": "GFPT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286603", "map_id": "DDB_G0286603", "name": "GFPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687188", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10687149", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q54KS2", "map_id": "Q54KS2", "name": "Core 8 (MUC4)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287193", "map_id": "DDB_G0287193", "name": "Core 8 (MUC4)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZU4", "map_id": "Q54ZU4", "name": "Core 8 (MUC19)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277357", "map_id": "DDB_G0277357", "name": "Core 8 (MUC19)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687186", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10700814", "map_id": "none", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700799", "map_id": "Q54RC3", "name": "top1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283205", "map_id": "DDB_G0283205", "name": "top1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700812", "map_id": "none", "name": "SUMO1:TOP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RC3", "map_id": "Q54RC3", "name": "top1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717887", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689659", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6799543", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799540", "map_id": "CHEBI:91284", "name": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10717884", "map_id": "Q55G89", "name": "ENGASE", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268520", "map_id": "DDB_G0268520", "name": "ENGASE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716434", "map_id": "none", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10716432", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677122", "map_id": "none", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855666", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677119", "map_id": "Q54MC0", "name": "pigw", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286111", "map_id": "DDB_G0286111", "name": "pigw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711139", "map_id": "none", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10673349", "map_id": "none", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673347", "map_id": "none", "name": "eIF4E:4E-BP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DU8", "map_id": "Q54DU8", "name": "febA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291990", "map_id": "DDB_G0291990", "name": "febA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673345", "map_id": "Q54DU8", "name": "febA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10685719", "map_id": "none", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449744", "map_id": "CHEBI:15750", "name": "DOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685716", "map_id": "Q86IX2", "name": "dolpp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0274591", "map_id": "DDB_G0274591", "name": "dolpp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698470", "map_id": "none", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698438", "map_id": "Q54MF7", "name": "PML", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285989", "map_id": "DDB_G0285989", "name": "PML", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698453", "map_id": "none", "name": "3SUMO1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MF7", "map_id": "Q54MF7", "name": "PML", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698467", "map_id": "none", "name": "UBE2I,HDAC7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54X15", "map_id": "Q54X15", "name": "hdaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279267", "map_id": "DDB_G0279267", "name": "hdaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VQ7", "map_id": "Q54VQ7", "name": "hdaC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280195", "map_id": "DDB_G0280195", "name": "hdaC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711352", "map_id": "none", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10705693", "map_id": "none", "name": "SFTPB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10677228", "map_id": "none", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855665", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162872", "map_id": "CHEBI:16214", "name": "dolichyl phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855659", "map_id": "CHEBI:53056", "name": "mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677225", "map_id": "none", "name": "GPI mannosyltransferase I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54IA4", "map_id": "Q54IA4", "name": "pigm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288899", "map_id": "DDB_G0288899", "name": "pigm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QP2", "map_id": "Q54QP2", "name": "pigX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283717", "map_id": "DDB_G0283717", "name": "pigX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717705", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10717501", "map_id": "Q55C16", "name": "uba1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10717703", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721722", "map_id": "none", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721714", "map_id": "none", "name": "SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KQ4", "map_id": "Q54KQ4", "name": "SHPRH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287171", "map_id": "DDB_G0287171", "name": "SHPRH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721697", "map_id": "Q54KQ4", "name": "SHPRH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10721724", "map_id": "none", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703192", "map_id": "none", "name": "MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10719266", "map_id": "none", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719256", "map_id": "B0G172", "name": "rabggtb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10719262", "map_id": "Q55DQ4", "name": "rabggta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10719264", "map_id": "none", "name": "RABGGTA:RABGGTB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10719258", "map_id": "none", "name": "FarC-PTP4A2:RABGGTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DU9", "map_id": "Q54DU9", "name": "FarC-PTP4A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292024", "map_id": "DDB_G0292024", "name": "FarC-PTP4A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718520", "map_id": "none", "name": "USP48 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10718471", "map_id": "none", "name": "USP48:K63polyUb-TRAF2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86K46", "map_id": "Q86K46", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293202", "map_id": "DDB_G0293202", "name": "TRAF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FD5", "map_id": "Q54FD5", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA0", "map_id": "Q55GA0", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AY4", "map_id": "Q86AY4", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C11", "map_id": "Q54C11", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556A3", "map_id": "Q556A3", "name": "USP48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274795", "map_id": "DDB_G0274795", "name": "USP48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FC5", "map_id": "Q54FC5", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FB9", "map_id": "Q54FB9", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WD3", "map_id": "Q54WD3", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXR0", "map_id": "Q1ZXR0", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA8", "map_id": "Q55GA8", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A66", "map_id": "Q55A66", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557K2", "map_id": "Q557K2", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557K0", "map_id": "Q557K0", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YP8", "map_id": "Q54YP8", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NN4", "map_id": "Q54NN4", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F79", "map_id": "Q54F79", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FG0", "map_id": "Q54FG0", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L54", "map_id": "Q86L54", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KX6", "map_id": "Q86KX6", "name": "TRAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11467", "map_id": "P11467", "name": "zfaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290961", "map_id": "DDB_G0290961", "name": "zfaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718517", "map_id": "none", "name": "USP48:TRAF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700592", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698376", "map_id": "none", "name": "SUMO3:UBE2I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674568", "map_id": "Q76NW2", "name": "H4b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700590", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10707609", "map_id": "none", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10707605", "map_id": "Q55BC4", "name": "USP14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271264", "map_id": "DDB_G0271264", "name": "USP14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10707607", "map_id": "none", "name": "ADRM1:26S proteasome:USP14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BC4", "map_id": "Q55BC4", "name": "USP14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10719260", "map_id": "none", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719254", "map_id": "Q54DU9", "name": "FarC-PTP4A2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10700140", "map_id": "none", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700138", "map_id": "none", "name": "SUMO1:PIAS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676985", "map_id": "none", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676976", "map_id": "Q9GRF8", "name": "efa1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676974", "map_id": "Q9GRF8", "name": "efa1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676981", "map_id": "B0G141", "name": "efa1G", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10717858", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10720438", "map_id": "none", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720435", "map_id": "none", "name": "Homologues of K48polyUb-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715078", "map_id": "Q55FY4", "name": "OTUD3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267906", "map_id": "DDB_G0267906", "name": "OTUD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700761", "map_id": "none", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700746", "map_id": "Q55BP5", "name": "top2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0270418", "map_id": "DDB_G0270418", "name": "top2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700759", "map_id": "none", "name": "SUMO1:TOP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BP5", "map_id": "Q55BP5", "name": "top2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717853", "map_id": "none", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10717765", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10717800", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54F00", "map_id": "Q54F00", "name": "Ub-C86-UBE2T", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291199", "map_id": "DDB_G0291199", "name": "Ub-C86-UBE2T", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10717851", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721441", "map_id": "none", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689176", "map_id": "none", "name": "Homologues of UBE2L3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721438", "map_id": "Q54UC0", "name": "dnapkcs", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10676955", "map_id": "none", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673430", "map_id": "Q553M7", "name": "rpl13a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676953", "map_id": "none", "name": "60s ribosomal complex lacking L13a subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710713", "map_id": "none", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710704", "map_id": "none", "name": "USP13:K63polyUb-BECN1,K63polyUb-USP10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54201", "map_id": "P54201", "name": "ubpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96612", "map_id": "O96612", "name": "ubpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275021", "map_id": "DDB_G0275021", "name": "ubpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710710", "map_id": "none", "name": "USP13:BECN1,USP10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685790", "map_id": "none", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449293", "map_id": "CHEBI:18341", "name": "N,N'-DCDOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449283", "map_id": "CHEBI:18396", "name": "MDCDD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685787", "map_id": "P90522", "name": "alg1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286011", "map_id": "DDB_G0286011", "name": "alg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685738", "map_id": "none", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532531", "map_id": "CHEBI:35374", "name": "Man1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10685735", "map_id": "none", "name": "PMM1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86B09", "map_id": "Q86B09", "name": "pmmB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272781", "map_id": "DDB_G0272781", "name": "pmmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X03", "map_id": "Q54X03", "name": "pmmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279289", "map_id": "DDB_G0279289", "name": "pmmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700634", "map_id": "none", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700619", "map_id": "Q1ZXA6", "name": "rad4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0292296", "map_id": "DDB_G0292296", "name": "rad4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700632", "map_id": "none", "name": "SUMO1:XPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXA6", "map_id": "Q1ZXA6", "name": "rad4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10689669", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205689", "map_id": "CHEBI:58189", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10689666", "map_id": "Q54Y16", "name": "FUT8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0278473", "map_id": "DDB_G0278473", "name": "FUT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685695", "map_id": "none", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449222", "map_id": "CHEBI:18278", "name": "GlcNAcDOLDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685692", "map_id": "P0CD61", "name": "alg7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290751", "map_id": "DDB_G0290751", "name": "alg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10705340", "map_id": "none", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane" }, { "id": "species_5684863", "map_id": "none", "name": "PC, PG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_5684869", "map_id": "none", "name": "PC, PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "species_10705337", "map_id": "Q8T5Z7", "name": "abcA1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane", "complex": "false" }, { "id": "DDB_G0291994", "map_id": "DDB_G0291994", "name": "abcA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677244", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855663", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855667", "map_id": "CHEBI:53058", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677241", "map_id": "Q54UQ5", "name": "PIGV", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0280891", "map_id": "DDB_G0280891", "name": "PIGV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717918", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717916", "map_id": "Q54TK0", "name": "nedd8l1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10669973", "map_id": "Q54TK0", "name": "nedd8l1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673551", "map_id": "Q54TK0", "name": "nedd8l1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10717911", "map_id": "none", "name": "UCHL3,USP7,USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10718833", "map_id": "none", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718821", "map_id": "none", "name": "Polyglycylated microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10718830", "map_id": "none", "name": "TTLL3,TTLL8,TTLL10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TU1", "map_id": "Q54TU1", "name": "TTLL8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281541", "map_id": "DDB_G0281541", "name": "TTLL8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677174", "map_id": "none", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10677171", "map_id": "none", "name": "GPI-GnT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q86K35", "map_id": "Q86K35", "name": "pigH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277289", "map_id": "DDB_G0277289", "name": "pigH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M40", "map_id": "Q54M40", "name": "pigC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286221", "map_id": "DDB_G0286221", "name": "pigC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WP5", "map_id": "Q54WP5", "name": "PIGQ-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279515", "map_id": "DDB_G0279515", "name": "PIGQ-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QB2", "map_id": "Q54QB2", "name": "PIGA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283965", "map_id": "DDB_G0283965", "name": "PIGA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JM6", "map_id": "Q86JM6", "name": "PIGP(26-158)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272006", "map_id": "DDB_G0272006", "name": "PIGP(26-158)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693457", "map_id": "none", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693453", "map_id": "none", "name": "ribosome:mRNA:polypeptide+signal", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10693451", "map_id": "none", "name": "Signal Recognition Particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75K18", "map_id": "Q75K18", "name": "srp54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275455", "map_id": "DDB_G0275455", "name": "srp54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554G7", "map_id": "Q554G7", "name": "srp19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275211", "map_id": "DDB_G0275211", "name": "srp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556L1", "map_id": "Q556L1", "name": "srp14-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272590", "map_id": "DDB_G0272590", "name": "srp14-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EP7", "map_id": "Q54EP7", "name": "srp72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291412", "map_id": "DDB_G0291412", "name": "srp72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE8", "map_id": "Q1ZXE8", "name": "srp68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285821", "map_id": "DDB_G0285821", "name": "srp68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GL2", "map_id": "Q55GL2", "name": "srp9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267622", "map_id": "DDB_G0267622", "name": "srp9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10693455", "map_id": "none", "name": "SRP:polypeptide+signal:ribosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700486", "map_id": "none", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698378", "map_id": "none", "name": "UBE2I:SUMO2,UBE2I:SUMO3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700484", "map_id": "none", "name": "Homologues of SUMO2,3-K203,K486-PARP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709672", "map_id": "none", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678138", "map_id": "none", "name": "K63-Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670158", "map_id": "Q86IJ1", "name": "psmD14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10717499", "map_id": "none", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717444", "map_id": "none", "name": "Ub-Cys625-UBA6:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717446", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA6 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717448", "map_id": "none", "name": "UBA6:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717497", "map_id": "none", "name": "Ub:E2 (UBA6 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721736", "map_id": "none", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10721572", "map_id": "none", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10721532", "map_id": "none", "name": "GPI-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54I77", "map_id": "Q54I77", "name": "cleaved GPI-CPM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288963", "map_id": "DDB_G0288963", "name": "cleaved GPI-CPM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WG1", "map_id": "Q54WG1", "name": "VNN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279675", "map_id": "DDB_G0279675", "name": "VNN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G06", "map_id": "Q54G06", "name": "xpnpep1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290501", "map_id": "DDB_G0290501", "name": "xpnpep1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2197633", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10721564", "map_id": "none", "name": "proteins with cleaved GPI-anchors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10721569", "map_id": "Q86AV9", "name": "pldG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0276919", "map_id": "DDB_G0276919", "name": "pldG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685457", "map_id": "none", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10685454", "map_id": "none", "name": "Homologues of SLC30A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "Q54F34", "map_id": "Q54F34", "name": "SLC30A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291141", "map_id": "DDB_G0291141", "name": "SLC30A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E98", "map_id": "Q55E98", "name": "SLC30A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685780", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449315", "map_id": "CHEBI:53023", "name": "(GlcNAc)2 (Man)6 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685777", "map_id": "Q54WW9", "name": "alg9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279349", "map_id": "DDB_G0279349", "name": "alg9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716436", "map_id": "none", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10698263", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698249", "map_id": "none", "name": "Homologues of SUMO1(2-101)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698260", "map_id": "none", "name": "SENP1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685703", "map_id": "none", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_110094", "map_id": "CHEBI:58069", "name": "CDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10685700", "map_id": "Q54MS7", "name": "DOLK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0285689", "map_id": "DDB_G0285689", "name": "DOLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710774", "map_id": "none", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710770", "map_id": "Q55BI3", "name": "yod1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271346", "map_id": "DDB_G0271346", "name": "yod1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710772", "map_id": "none", "name": "YOD1:VCP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BI3", "map_id": "Q55BI3", "name": "yod1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717864", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689276", "map_id": "Q55C16", "name": "uba1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10709185", "map_id": "none", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709180", "map_id": "none", "name": "USP16,USP21:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86KB3", "map_id": "Q86KB3", "name": "USP45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274207", "map_id": "DDB_G0274207", "name": "USP45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709182", "map_id": "none", "name": "USP16,USP22:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685465", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10685462", "map_id": "Q54QU8", "name": "SLC30A8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "DDB_G0283629", "map_id": "DDB_G0283629", "name": "SLC30A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700068", "map_id": "none", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700053", "map_id": "Q54CE0", "name": "ddx17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700066", "map_id": "none", "name": "SUMO1:DDX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685746", "map_id": "none", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449371", "map_id": "CHEBI:37637", "name": "(GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_532542", "map_id": "CHEBI:15812", "name": "DbGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449649", "map_id": "CHEBI:59081", "name": "(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685743", "map_id": "Q54QG6", "name": "alg6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0283841", "map_id": "DDB_G0283841", "name": "alg6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709951", "map_id": "none", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5693930", "map_id": "CHEBI:18915", "name": "Gal1,3GlcNAc group", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5693933", "map_id": "CHEBI:18914", "name": "Gal1,3Fuc1,4GlcNAc group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10709948", "map_id": "none", "name": "Homologues of FUT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55FA8", "map_id": "Q55FA8", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293768", "map_id": "DDB_G0293768", "name": "FUT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ9", "map_id": "Q54PJ9", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BB7", "map_id": "Q54BB7", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK0", "map_id": "Q54PK0", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK3", "map_id": "Q54PK3", "name": "fut4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284551", "map_id": "DDB_G0284551", "name": "fut4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L56", "map_id": "Q54L56", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RA6", "map_id": "Q54RA6", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687208", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10687206", "map_id": "none", "name": "Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10700701", "map_id": "none", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700699", "map_id": "none", "name": "2SUMO1:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700091", "map_id": "none", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672384", "map_id": "none", "name": "Homologues of DDX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700089", "map_id": "none", "name": "SUMO1:DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700359", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10709911", "map_id": "none", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6784247", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784248", "map_id": "CHEBI:59520", "name": "NGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784249", "map_id": "CHEBI:2181", "name": "L-fucose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10709908", "map_id": "none", "name": "FUCA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "P10901", "map_id": "P10901", "name": "alfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274391", "map_id": "DDB_G0274391", "name": "alfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551C1", "map_id": "Q551C1", "name": "FUCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276661", "map_id": "DDB_G0276661", "name": "FUCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700546", "map_id": "none", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700537", "map_id": "Q54DM3", "name": "BLM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700543", "map_id": "Q54DM3", "name": "4SUMO2,3-BLM", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10700462", "map_id": "none", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700460", "map_id": "none", "name": "SUMO1:TOPORS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UA7", "map_id": "Q54UA7", "name": "SUMO1-K560-TOPORS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10719275", "map_id": "none", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719271", "map_id": "none", "name": "CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700644", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700642", "map_id": "Q86IG6", "name": "SUMO2,3-K1840-MDC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10673657", "map_id": "none", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673336", "map_id": "none", "name": "40S:Met-tRNAi:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673647", "map_id": "none", "name": "eIF5B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700794", "map_id": "none", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700792", "map_id": "Q55BP5", "name": "top2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10700185", "map_id": "none", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698750", "map_id": "Q54WP8", "name": "DAXX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0279509", "map_id": "DDB_G0279509", "name": "SUMO1-K630,K631-DAXX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700183", "map_id": "none", "name": "2SUMO1:DAXX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54WP8", "map_id": "Q54WP8", "name": "SUMO1-K630,K631-DAXX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710812", "map_id": "none", "name": "USP10 deubiquitinates SNX3, CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710805", "map_id": "none", "name": "USP10:PolyUb-SNX3,PolyUb-CTFR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54UN7", "map_id": "Q54UN7", "name": "SNX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280921", "map_id": "DDB_G0280921", "name": "SNX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710809", "map_id": "none", "name": "USP10:SNX3,CTFR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10689661", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689657", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "reaction_10698392", "map_id": "none", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698381", "map_id": "Q54C05", "name": "SUMO2,3-BRCA1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10698599", "map_id": "none", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10697630", "map_id": "none", "name": "Cohesin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698563", "map_id": "none", "name": "SUMOylated Cohesin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698596", "map_id": "none", "name": "SMC5-SMC6 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54FE3", "map_id": "Q54FE3", "name": "smc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290919", "map_id": "DDB_G0290919", "name": "smc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X37", "map_id": "Q54X37", "name": "NSMCE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279231", "map_id": "DDB_G0279231", "name": "NSMCE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T56", "map_id": "Q54T56", "name": "EID3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281991", "map_id": "DDB_G0281991", "name": "EID3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I56", "map_id": "Q54I56", "name": "smc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288993", "map_id": "DDB_G0288993", "name": "smc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HN3", "map_id": "Q54HN3", "name": "NSMCE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289341", "map_id": "DDB_G0289341", "name": "NSMCE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698300", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698296", "map_id": "Q54SX2", "name": "SUMO3(1-103)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698298", "map_id": "Q54SX2", "name": "SUMO3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10677213", "map_id": "none", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10677210", "map_id": "Q54PM5", "name": "PIGB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284435", "map_id": "DDB_G0284435", "name": "PIGB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710428", "map_id": "none", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710419", "map_id": "none", "name": "USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710425", "map_id": "none", "name": "USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710452", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710445", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ZP5", "map_id": "Q54ZP5", "name": "WDR48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277533", "map_id": "DDB_G0277533", "name": "WDR48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G37", "map_id": "Q54G37", "name": "usp12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290453", "map_id": "DDB_G0290453", "name": "usp12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UB2", "map_id": "Q54UB2", "name": "WDR20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281319", "map_id": "DDB_G0281319", "name": "WDR20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710449", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10719196", "map_id": "none", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10719191", "map_id": "none", "name": "USP4:PolyUb-TRAF2, PolyUb-TRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10719193", "map_id": "none", "name": "TRAF2, TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710400", "map_id": "B0G199", "name": "USP4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10710405", "map_id": "none", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710396", "map_id": "none", "name": "USP25:PolyUb-DDX58", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710398", "map_id": "none", "name": "USP25:DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10673667", "map_id": "none", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673294", "map_id": "none", "name": "EIF2S1:EIF2S2:EIF2S3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673334", "map_id": "Q54LA1", "name": "eif5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0286753", "map_id": "DDB_G0286753", "name": "eif5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700260", "map_id": "none", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700245", "map_id": "Q54QV3", "name": "yakA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283605", "map_id": "DDB_G0283605", "name": "yakA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700258", "map_id": "none", "name": "SUMO1:HIPK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QV3", "map_id": "Q54QV3", "name": "yakA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673359", "map_id": "none", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72393", "map_id": "none", "name": "Met-tRNAi", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10698243", "map_id": "none", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698225", "map_id": "none", "name": "UBA2:SAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54WI4", "map_id": "Q54WI4", "name": "sae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279641", "map_id": "DDB_G0279641", "name": "sae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L40", "map_id": "Q54L40", "name": "uba2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286919", "map_id": "DDB_G0286919", "name": "uba2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698240", "map_id": "none", "name": "SUMO1:UBA2:SAE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698321", "map_id": "none", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10717914", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673140", "map_id": "none", "name": "Homologues of RPS27A(77-156)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677002", "map_id": "none", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677000", "map_id": "none", "name": "eEF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P15112", "map_id": "P15112", "name": "efbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676951", "map_id": "none", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676926", "map_id": "Q553M7", "name": "phospho-rpl13a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676947", "map_id": "none", "name": "43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54BM2", "map_id": "Q54BM2", "name": "pabpc1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293558", "map_id": "DDB_G0293558", "name": "pabpc1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G90", "map_id": "Q54G90", "name": "PABPC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290307", "map_id": "DDB_G0290307", "name": "PABPC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXC2", "map_id": "Q1ZXC2", "name": "pabpc1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290745", "map_id": "DDB_G0290745", "name": "pabpc1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676949", "map_id": "none", "name": "phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10706098", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10706095", "map_id": "none", "name": "ATXN3,ATXN3L,JOSD1,JOSD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DI9", "map_id": "Q55DI9", "name": "JOSD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269646", "map_id": "DDB_G0269646", "name": "JOSD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698483", "map_id": "none", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698480", "map_id": "Q54MF7", "name": "SUMO3-K65,K160,K490-PML", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10717855", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10717763", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710584", "map_id": "none", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710535", "map_id": "none", "name": "CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10710581", "map_id": "none", "name": "TRAF2,TRAF6,IKBKG,RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700105", "map_id": "none", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700102", "map_id": "none", "name": "Homologues of SUMO2-K53-DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10717866", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10686910", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10686907", "map_id": "Q550W6", "name": "slc35c1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0277007", "map_id": "DDB_G0277007", "name": "slc35c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700741", "map_id": "none", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699886", "map_id": "Q55FN5", "name": "hdaA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10700739", "map_id": "none", "name": "SUMO1:HDAC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700532", "map_id": "none", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700530", "map_id": "none", "name": "3SUMO1:RAD52", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10677205", "map_id": "none", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10677202", "map_id": "Q54WY9", "name": "PIGN", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279313", "map_id": "DDB_G0279313", "name": "PIGN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709123", "map_id": "none", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709118", "map_id": "none", "name": "USP5:PolyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10709120", "map_id": "none", "name": "USP5:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699567", "map_id": "none", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699553", "map_id": "Q1ZXA2", "name": "mybS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293468", "map_id": "DDB_G0293468", "name": "mybS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699556", "map_id": "Q1ZXA2", "name": "mybS", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699564", "map_id": "none", "name": "PIAS1,3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710662", "map_id": "none", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710657", "map_id": "none", "name": "USP49:Ub-histone H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710659", "map_id": "none", "name": "USP49:Histone H2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700223", "map_id": "none", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700221", "map_id": "none", "name": "SUMO1:ING2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10677236", "map_id": "none", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677233", "map_id": "Q54C64", "name": "pigl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293136", "map_id": "DDB_G0293136", "name": "pigl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710615", "map_id": "none", "name": "USP47 deubiquitinates POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710610", "map_id": "none", "name": "USP47:PolyUb-POLB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710612", "map_id": "none", "name": "USP47:POLB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685782", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10673663", "map_id": "none", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673272", "map_id": "none", "name": "eIF3 subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700351", "map_id": "none", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419987", "map_id": "CHEBI:17407", "name": "E,E-FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4419982", "map_id": "CHEBI:37531", "name": "pPPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10700348", "map_id": "none", "name": "DHDDS:NUS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54EN3", "map_id": "Q54EN3", "name": "DHDDS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291436", "map_id": "DDB_G0291436", "name": "DHDDS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AK1", "map_id": "Q55AK1", "name": "NUS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271830", "map_id": "DDB_G0271830", "name": "NUS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685687", "map_id": "none", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449638", "map_id": "CHEBI:53020", "name": "(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685684", "map_id": "Q554E2", "name": "alg8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0275261", "map_id": "DDB_G0275261", "name": "alg8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687242", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10687240", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10700789", "map_id": "none", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700770", "map_id": "none", "name": "Homologues of TOP2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P90520", "map_id": "P90520", "name": "top2mt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279737", "map_id": "DDB_G0279737", "name": "top2mt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10700787", "map_id": "none", "name": "SUMO1:TOP2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698272", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698268", "map_id": "Q54SX2", "name": "SUMO2(1-95)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698270", "map_id": "Q54SX2", "name": "SUMO2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10685678", "map_id": "none", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449298", "map_id": "CHEBI:53022", "name": "(GlcNAc)2 (Man)5 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685670", "map_id": "Q55F69", "name": "alg3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0268238", "map_id": "DDB_G0268238", "name": "alg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687198", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10687196", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10710692", "map_id": "none", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710685", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C28", "map_id": "Q54C28", "name": "RUVBL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293226", "map_id": "DDB_G0293226", "name": "RUVBL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710689", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:CCNA1,CCNA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700614", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700612", "map_id": "none", "name": "SUMO1:HIST1H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10673357", "map_id": "none", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10711118", "map_id": "none", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787678", "map_id": "CHEBI:42589", "name": "beta-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711115", "map_id": "Q55DE9", "name": "FUK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269678", "map_id": "DDB_G0269678", "name": "FUK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710386", "map_id": "none", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10710383", "map_id": "Q54Q40", "name": "DG1039", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284037", "map_id": "DDB_G0284037", "name": "DG1039", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720401", "map_id": "none", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720396", "map_id": "none", "name": "CHMs:GGC-RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720398", "map_id": "none", "name": "RGGTA:RGGTB:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10681376", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10681364", "map_id": "P13651", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681373", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556G4", "map_id": "Q556G4", "name": "dohh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272634", "map_id": "DDB_G0272634", "name": "dohh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685764", "map_id": "none", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449737", "map_id": "CHEBI:59085", "name": "(GlcNAc)2 (Man)2 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10685761", "map_id": "Q7KWM5", "name": "alg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0272730", "map_id": "DDB_G0272730", "name": "alg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721465", "map_id": "none", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721445", "map_id": "none", "name": "RRAGA:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10670813", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670672", "map_id": "Q54QM6", "name": "cdc25", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670794", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10670825", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670822", "map_id": "Q54MH0", "name": "phospho-fhkD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285963", "map_id": "DDB_G0285963", "name": "phospho-fhkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670792", "map_id": "none", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670790", "map_id": "none", "name": "Ub-p-S123-CDC25A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10696253", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2162223", "map_id": "none", "name": "GlcNAc-GlcA-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10692393", "map_id": "none", "name": "HEXA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10724755", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10692395", "map_id": "none", "name": "bHEXB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10710763", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710740", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54TY2", "map_id": "Q54TY2", "name": "Ub-ERCC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281441", "map_id": "DDB_G0281441", "name": "Ub-ERCC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710760", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710800", "map_id": "none", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710791", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54X62", "map_id": "Q54X62", "name": "ZNF830", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279177", "map_id": "DDB_G0279177", "name": "ZNF830", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710797", "map_id": "none", "name": "TC-NER pre-incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710717", "map_id": "none", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672165", "map_id": "none", "name": "RNA Polymerase II holoenzyme complex (unphosphorylated)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5688114", "map_id": "none", "name": "Distorted dsDNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10710715", "map_id": "none", "name": "Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710742", "map_id": "none", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710738", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710729", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710744", "map_id": "none", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710727", "map_id": "Q54TY2", "name": "ERCC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10710719", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710722", "map_id": "none", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6781829", "map_id": "CHEBI:17972", "name": "ribonucleoside triphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10683780", "map_id": "none", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683777", "map_id": "none", "name": "AKT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10683554", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722650", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10722647", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q55EU8", "map_id": "Q55EU8", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268966", "map_id": "DDB_G0268966", "name": "LIPF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU9", "map_id": "Q55EU9", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU1", "map_id": "Q55EU1", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684783", "map_id": "none", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428037", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:90799", "map_id": "CHEBI:90799", "name": "CHEBI:90799", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47923", "map_id": "CHEBI:47923", "name": "CHEBI:47923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428026", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684780", "map_id": "none", "name": "PEPT cotransporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q559N7", "map_id": "Q559N7", "name": "SLC15A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272550", "map_id": "DDB_G0272550", "name": "SLC15A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559I6", "map_id": "Q559I6", "name": "SLC15A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G06", "map_id": "Q55G06", "name": "SLC15A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724565", "map_id": "none", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9757634", "map_id": "CHEBI:61557", "name": "NTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10674195", "map_id": "none", "name": "pol II transcription complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10724563", "map_id": "none", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674840", "map_id": "none", "name": "pol II transcription complex containing 3 Nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675549", "map_id": "none", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674909", "map_id": "none", "name": "pol II transcription complex containing 9 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675547", "map_id": "none", "name": "pol II transcription complex containing 11 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674983", "map_id": "none", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674862", "map_id": "none", "name": "pol II open pre-initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674882", "map_id": "none", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674880", "map_id": "none", "name": "pol II transcription complex containing 4 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674843", "map_id": "none", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674868", "map_id": "none", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674866", "map_id": "none", "name": "Pol II initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6806881", "map_id": "CHEBI:61557", "name": "NTP(4-)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10674878", "map_id": "none", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674874", "map_id": "none", "name": "Pol II Initiation complex with phosphodiester-PPi intermediate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676040", "map_id": "none", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674911", "map_id": "none", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674876", "map_id": "none", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10683703", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683700", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q55CT6", "map_id": "Q55CT6", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288735", "map_id": "DDB_G0288735", "name": "ACOX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683737", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10683734", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "B0G110", "map_id": "B0G110", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54II1", "map_id": "Q54II1", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RB0", "map_id": "Q54RB0", "name": "acoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283261", "map_id": "DDB_G0283261", "name": "acoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MMS1", "map_id": "Q8MMS1", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JL8", "map_id": "Q75JL8", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683740", "map_id": "none", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389982", "map_id": "CHEBI:63914", "name": "3-hydroxypristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10683742", "map_id": "none", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389996", "map_id": "CHEBI:15371", "name": "3-ketopristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10693605", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693602", "map_id": "none", "name": "PLCbz", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680017", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680014", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54IH4", "map_id": "Q54IH4", "name": "NMNAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288757", "map_id": "DDB_G0288757", "name": "NMNAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671897", "map_id": "none", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671894", "map_id": "none", "name": "glycogen-glycogenin-2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54L24", "map_id": "Q54L24", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286945", "map_id": "DDB_G0286945", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10671858", "map_id": "none", "name": "limit dextrin-glycogenin-2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29548", "map_id": "CHEBI:16077", "name": "G1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671889", "map_id": "none", "name": "PGYL dimer a form", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q00766", "map_id": "Q00766", "name": "glpV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281383", "map_id": "DDB_G0281383", "name": "glpV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682008", "map_id": "none", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215573", "map_id": "CHEBI:15367", "name": "atRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_215584", "map_id": "CHEBI:63795", "name": "4OH-atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10675426", "map_id": "none", "name": "Homologues of CYP2S1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54SV9", "map_id": "Q54SV9", "name": "cyp515B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282283", "map_id": "DDB_G0282283", "name": "cyp515B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXL2", "map_id": "Q1ZXL2", "name": "cyp518B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275197", "map_id": "DDB_G0275197", "name": "cyp518B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556M5", "map_id": "Q556M5", "name": "cyp508A1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273045", "map_id": "DDB_G0273045", "name": "cyp508A1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NY3", "map_id": "Q54NY3", "name": "cyp554A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284923", "map_id": "DDB_G0284923", "name": "cyp554A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DT2", "map_id": "Q54DT2", "name": "cyp516A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292168", "map_id": "DDB_G0292168", "name": "cyp516A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG3", "map_id": "Q1ZXG3", "name": "cyp522A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282769", "map_id": "DDB_G0282769", "name": "cyp522A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556M4", "map_id": "Q556M4", "name": "cyp508A2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272604", "map_id": "DDB_G0272604", "name": "cyp508A2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF3", "map_id": "Q1ZXF3", "name": "cyp517A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284647", "map_id": "DDB_G0284647", "name": "cyp517A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AJ4", "map_id": "Q55AJ4", "name": "cyp516B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271778", "map_id": "DDB_G0271778", "name": "cyp516B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A22", "map_id": "Q86A22", "name": "cyp515A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272704", "map_id": "DDB_G0272704", "name": "cyp515A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA4", "map_id": "Q1ZXA4", "name": "cyp508D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292790", "map_id": "DDB_G0292790", "name": "cyp508D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZM4", "map_id": "Q54ZM4", "name": "cyp518A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277545", "map_id": "DDB_G0277545", "name": "cyp518A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LT7", "map_id": "Q54LT7", "name": "cyp519E1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286419", "map_id": "DDB_G0286419", "name": "cyp519E1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXL7", "map_id": "Q1ZXL7", "name": "cyp508A3-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273047", "map_id": "DDB_G0273047", "name": "cyp508A3-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CS3", "map_id": "Q54CS3", "name": "cyp508C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292792", "map_id": "DDB_G0292792", "name": "cyp508C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF5", "map_id": "Q1ZXF5", "name": "cyp508A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LA8", "map_id": "Q54LA8", "name": "cyp555A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286743", "map_id": "DDB_G0286743", "name": "cyp555A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QD0", "map_id": "Q54QD0", "name": "cyp517A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283933", "map_id": "DDB_G0283933", "name": "cyp517A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QD2", "map_id": "Q54QD2", "name": "cyp517A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283929", "map_id": "DDB_G0283929", "name": "cyp517A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SK0", "map_id": "Q54SK0", "name": "cyp508B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282419", "map_id": "DDB_G0282419", "name": "cyp508B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q53", "map_id": "Q54Q53", "name": "cyp519B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284089", "map_id": "DDB_G0284089", "name": "cyp519B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA1", "map_id": "Q1ZXA1", "name": "cyp521A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293738", "map_id": "DDB_G0293738", "name": "cyp521A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EM5", "map_id": "Q54EM5", "name": "cyp519D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291448", "map_id": "DDB_G0291448", "name": "cyp519D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671298", "map_id": "none", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70829", "map_id": "CHEBI:15449", "name": "aMbHBUT-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671295", "map_id": "none", "name": "HSD17B10 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86JE3", "map_id": "Q86JE3", "name": "HSD17B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272128", "map_id": "DDB_G0272128", "name": "HSD17B10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723508", "map_id": "none", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_376186", "map_id": "CHEBI:16523", "name": "D-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10723502", "map_id": "none", "name": "PXLP-K56-SRR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HH2", "map_id": "Q54HH2", "name": "srr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289463", "map_id": "DDB_G0289463", "name": "srr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673704", "map_id": "none", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111647", "map_id": "CHEBI:58228", "name": "CAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673695", "map_id": "none", "name": "CAD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20054", "map_id": "P20054", "name": "pyr1-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276335", "map_id": "DDB_G0276335", "name": "pyr1-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723971", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024759", "map_id": "none", "name": "RvD1, RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:81565", "map_id": "CHEBI:81565", "name": "CHEBI:81565", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:81564", "map_id": "CHEBI:81564", "name": "CHEBI:81564", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682328", "map_id": "none", "name": "LTA4H:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52922", "map_id": "P52922", "name": "lkhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269148", "map_id": "DDB_G0269148", "name": "lkhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712153", "map_id": "none", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6798337", "map_id": "CHEBI:19324", "name": "2,3BPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10712150", "map_id": "none", "name": "BPGM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684856", "map_id": "none", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684853", "map_id": "none", "name": "SPHK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10682020", "map_id": "none", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211892", "map_id": "CHEBI:7772", "name": "Losec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211944", "map_id": "CHEBI:63840", "name": "HOMZ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682015", "map_id": "none", "name": "Cytochrome P450 (CYP2C8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10686707", "map_id": "none", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30004", "map_id": "CHEBI:57700", "name": "2M3OPROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671343", "map_id": "none", "name": "HIBADH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54CX6", "map_id": "Q54CX6", "name": "hibA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292566", "map_id": "DDB_G0292566", "name": "hibA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671725", "map_id": "none", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29732", "map_id": "CHEBI:17363", "name": "RU5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671722", "map_id": "none", "name": "PGD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8TA03", "map_id": "Q8TA03", "name": "gnd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277885", "map_id": "DDB_G0277885", "name": "gnd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674017", "map_id": "none", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111427", "map_id": "CHEBI:58467", "name": "FAICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29602", "map_id": "CHEBI:58053", "name": "IMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674014", "map_id": "none", "name": "ATIC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86L14", "map_id": "Q86L14", "name": "purH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277087", "map_id": "DDB_G0277087", "name": "purH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698613", "map_id": "none", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698610", "map_id": "none", "name": "MTRR:MTR(cob(II)alamin)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3149479", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55G48", "map_id": "Q55G48", "name": "MTRR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267824", "map_id": "DDB_G0267824", "name": "MTRR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678886", "map_id": "none", "name": "MTRR:MTR(MeCbl)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28115", "map_id": "CHEBI:28115", "name": "CHEBI:28115", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711102", "map_id": "none", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670851", "map_id": "none", "name": "PGM2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UQ2", "map_id": "Q54UQ2", "name": "pgmB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280897", "map_id": "DDB_G0280897", "name": "pgmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671129", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10671103", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KB7", "map_id": "Q54KB7", "name": "gluD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287469", "map_id": "DDB_G0287469", "name": "gluD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10699261", "map_id": "none", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699205", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GH4", "map_id": "Q55GH4", "name": "phospho-glcS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267674", "map_id": "DDB_G0267674", "name": "phospho-glcS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699258", "map_id": "none", "name": "polyGlc-GYG1:GYS1-b tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724003", "map_id": "none", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025001", "map_id": "CHEBI:132228", "name": "13(S),14(S)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673836", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673833", "map_id": "none", "name": "CTPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54V77", "map_id": "Q54V77", "name": "ctps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280567", "map_id": "DDB_G0280567", "name": "ctps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671521", "map_id": "none", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71019", "map_id": "CHEBI:15466", "name": "MEMA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71009", "map_id": "CHEBI:15465", "name": "L-MM-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671518", "map_id": "Q553V2", "name": "mcee", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0275181", "map_id": "DDB_G0275181", "name": "mcee", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723948", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022660", "map_id": "CHEBI:137038", "name": "18(S)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693658", "map_id": "none", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629753", "map_id": "CHEBI:18384", "name": "I4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693655", "map_id": "none", "name": "INPP1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869K3", "map_id": "Q869K3", "name": "bpnt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275663", "map_id": "DDB_G0275663", "name": "bpnt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723952", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023712", "map_id": "CHEBI:81559", "name": "18(R)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679959", "map_id": "none", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196778", "map_id": "CHEBI:15468", "name": "DP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679943", "map_id": "Q55FK9", "name": "COASY", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0268566", "map_id": "DDB_G0268566", "name": "COASY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677355", "map_id": "none", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671760", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UP4", "map_id": "Q54UP4", "name": "tal", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280909", "map_id": "DDB_G0280909", "name": "tal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693645", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693642", "map_id": "none", "name": "PTEN:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724042", "map_id": "none", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027029", "map_id": "CHEBI:137347", "name": "14(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027326", "map_id": "none", "name": "14(S),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137360", "map_id": "CHEBI:137360", "name": "CHEBI:137360", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137354", "map_id": "CHEBI:137354", "name": "CHEBI:137354", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675234", "map_id": "none", "name": "Homologues of CYP2E1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723997", "map_id": "none", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024012", "map_id": "CHEBI:136113", "name": "17(S)-Hp-DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024883", "map_id": "CHEBI:138653", "name": "PDX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696203", "map_id": "none", "name": "Homologues of ALOX15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693628", "map_id": "none", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023935", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023901", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10693625", "map_id": "Q54TI0", "name": "IPMK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281737", "map_id": "DDB_G0281737", "name": "ITPKB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697783", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:61402", "name": "ITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10697780", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LQ6", "map_id": "Q54LQ6", "name": "itpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286495", "map_id": "DDB_G0286495", "name": "itpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696210", "map_id": "none", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142811", "map_id": "CHEBI:15626", "name": "12S-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696207", "map_id": "none", "name": "ALOX12/15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671658", "map_id": "none", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31135", "map_id": "CHEBI:17105", "name": "4MAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31175", "map_id": "CHEBI:18034", "name": "4FAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671655", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10683688", "map_id": "none", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389822", "map_id": "CHEBI:29805", "name": "glycolate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389678", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683685", "map_id": "none", "name": "HAO1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54E41", "map_id": "Q54E41", "name": "haox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291814", "map_id": "DDB_G0291814", "name": "haox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693703", "map_id": "none", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2023856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10693700", "map_id": "none", "name": "PL(C)D4:3xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54SA1", "map_id": "Q54SA1", "name": "pldZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282579", "map_id": "DDB_G0282579", "name": "pldZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K50", "map_id": "Q54K50", "name": "pldY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287649", "map_id": "DDB_G0287649", "name": "pldY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724425", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605607", "map_id": "CHEBI:140878", "name": "LeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10716913", "map_id": "none", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8848288", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_164991", "map_id": "CHEBI:33184", "name": "LCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:61907", "map_id": "CHEBI:61907", "name": "CHEBI:61907", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716907", "map_id": "Q5FXM5", "name": "acbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0270658", "map_id": "DDB_G0270658", "name": "acbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716911", "map_id": "none", "name": "DBI,ACBD7:MCFA-CoA,LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q5FXM5", "map_id": "Q5FXM5", "name": "acbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682071", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682068", "map_id": "none", "name": "Homologues of CYP2U1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10699251", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699246", "map_id": "none", "name": "GYG2:GYS2-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699248", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723985", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024797", "map_id": "CHEBI:138641", "name": "4(S)-Hp-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10711963", "map_id": "none", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10709959", "map_id": "Q54JV8", "name": "gcvH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10711952", "map_id": "none", "name": "octanoyl:NDUFAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:25650", "map_id": "CHEBI:25650", "name": "CHEBI:25650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E22", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291866", "map_id": "DDB_G0291866", "name": "phospho-ndufab1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711955", "map_id": "Q54JV8", "name": "gcvH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10711950", "map_id": "Q54E22", "name": "ndufab1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10711960", "map_id": "Q553T7", "name": "LIPT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0275417", "map_id": "DDB_G0275417", "name": "LIPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674313", "map_id": "none", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73871", "map_id": "CHEBI:57286", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113559", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671305", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86AD9", "map_id": "Q86AD9", "name": "ACAT1(35-427)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271544", "map_id": "DDB_G0271544", "name": "ACAT1(35-427)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671390", "map_id": "none", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30158", "map_id": "CHEBI:18327", "name": "NF-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111355", "map_id": "CHEBI:57453", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_70919", "map_id": "CHEBI:15639", "name": "FITHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671387", "map_id": "none", "name": "FTCD octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JL3", "map_id": "Q54JL3", "name": "ftcd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287977", "map_id": "DDB_G0287977", "name": "ftcd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714313", "map_id": "none", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429579", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10714310", "map_id": "none", "name": "MAN2C1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K67", "map_id": "Q54K67", "name": "manG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287577", "map_id": "DDB_G0287577", "name": "manG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722598", "map_id": "none", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8959518", "map_id": "CHEBI:16144", "name": "SELP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10722595", "map_id": "Q94497", "name": "selD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282367", "map_id": "DDB_G0282367", "name": "selD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675543", "map_id": "none", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_39703", "map_id": "LigandDisplayForward?ligandId=6953", "name": "DEXM", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76455", "map_id": "LigandDisplayForward?ligandId=9052", "name": "DEXT", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10675540", "map_id": "none", "name": "Cytochrome P450 (CYP2D6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10686661", "map_id": "none", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10686658", "map_id": "none", "name": "PXLP-K341-GPT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54MJ7", "map_id": "Q54MJ7", "name": "gpt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285899", "map_id": "DDB_G0285899", "name": "gpt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709689", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10709686", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TC2", "map_id": "Q54TC2", "name": "adh5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281865", "map_id": "DDB_G0281865", "name": "adh5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721205", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10721196", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54P40", "map_id": "Q54P40", "name": "isca2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284809", "map_id": "DDB_G0284809", "name": "isca2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VS1", "map_id": "Q54VS1", "name": "isca1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280173", "map_id": "DDB_G0280173", "name": "isca1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721184", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555C8", "map_id": "Q555C8", "name": "grx5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274657", "map_id": "DDB_G0274657", "name": "grx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721182", "map_id": "Q555C8", "name": "grx5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10721198", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721203", "map_id": "Q54UQ6", "name": "HSCB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0280889", "map_id": "DDB_G0280889", "name": "HSCB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721413", "map_id": "none", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938313", "map_id": "CHEBI:16753", "name": "Pantetheine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196820", "map_id": "CHEBI:7916", "name": "PanK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721410", "map_id": "none", "name": "VNN1,VNN2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10673730", "map_id": "none", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:58017", "name": "PRPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673727", "map_id": "none", "name": "PRPS2 dimer, PRPS1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QU9", "map_id": "Q54QU9", "name": "prsC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283627", "map_id": "DDB_G0283627", "name": "prsC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PA9", "map_id": "Q54PA9", "name": "prsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284669", "map_id": "DDB_G0284669", "name": "prsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JN8", "map_id": "Q75JN8", "name": "prsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272246", "map_id": "DDB_G0272246", "name": "prsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675882", "map_id": "none", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10675879", "map_id": "Q54QJ9", "name": "adkA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "DDB_G0283805", "map_id": "DDB_G0283805", "name": "adkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10715965", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10715962", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q556W1", "map_id": "Q556W1", "name": "ddo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273291", "map_id": "DDB_G0273291", "name": "ddo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671413", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671410", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P83401", "map_id": "P83401", "name": "ALDH7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276821", "map_id": "DDB_G0276821", "name": "ALDH7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724451", "map_id": "none", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605685", "map_id": "CHEBI:140918", "name": "Type 2 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605661", "map_id": "CHEBI:140916", "name": "sLeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10724448", "map_id": "none", "name": "FUT3,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10671288", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671285", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54RR5", "map_id": "Q54RR5", "name": "acadsb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282967", "map_id": "DDB_G0282967", "name": "acadsb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679946", "map_id": "none", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196767", "map_id": "CHEBI:16858", "name": "PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10674328", "map_id": "none", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_83909", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674325", "map_id": "Q54KF3", "name": "ada", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287371", "map_id": "DDB_G0287371", "name": "ada", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679969", "map_id": "none", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196834", "map_id": "CHEBI:15769", "name": "PPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679966", "map_id": "none", "name": "3xPPCDC:3xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Y51", "map_id": "Q54Y51", "name": "ppcdc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278413", "map_id": "DDB_G0278413", "name": "ppcdc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699233", "map_id": "none", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699228", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699230", "map_id": "none", "name": "polyGlc-GYG2:GYS2-a tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710929", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10710926", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q86H28", "map_id": "Q86H28", "name": "prodh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686182", "map_id": "none", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686180", "map_id": "none", "name": "PGYM b dimer:AMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34114", "map_id": "P34114", "name": "glpD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291123", "map_id": "DDB_G0291123", "name": "glpD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10671835", "map_id": "none", "name": "PGYM dimer, b form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693497", "map_id": "none", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_870330", "map_id": "CHEBI:18297", "name": "I1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693494", "map_id": "none", "name": "IMPA1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54U72", "map_id": "Q54U72", "name": "impa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281239", "map_id": "DDB_G0281239", "name": "impa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683752", "map_id": "none", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10714363", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714360", "map_id": "none", "name": "GNPDA1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XK9", "map_id": "Q54XK9", "name": "gnpda1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278873", "map_id": "DDB_G0278873", "name": "gnpda1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680566", "map_id": "none", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200640", "map_id": "CHEBI:65049", "name": "5,10-methenyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680525", "map_id": "none", "name": "MTHFD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VK0", "map_id": "Q54VK0", "name": "MTHFD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283121", "map_id": "DDB_G0283121", "name": "MTHFD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RI8", "map_id": "Q54RI8", "name": "MTHFD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675479", "map_id": "none", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_39417", "map_id": "CHEBI:28509", "name": "VC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156524", "map_id": "CHEBI:29129", "name": "2CEO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10675476", "map_id": "none", "name": "Cytochrome P450 (CYP2E1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723977", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10724007", "map_id": "none", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025155", "map_id": "CHEBI:65136", "name": "DPAn-6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9025151", "map_id": "none", "name": "17(S)-HDPAn-6, 10(S),17(S)-diHDPAn-6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138674", "map_id": "CHEBI:138674", "name": "CHEBI:138674", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138673", "map_id": "CHEBI:138673", "name": "CHEBI:138673", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721165", "map_id": "none", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668566", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662670", "map_id": "CHEBI:2003", "name": "DHICA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_8878586", "map_id": "CHEBI:81394", "name": "IQCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668574", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10721162", "map_id": "none", "name": "Homologues of TYRP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "Q54QT0", "map_id": "Q54QT0", "name": "TYRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283653", "map_id": "DDB_G0283653", "name": "TYRP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QT1", "map_id": "Q54QT1", "name": "TYRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693637", "map_id": "none", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994146", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10684814", "map_id": "none", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428182", "map_id": "CHEBI:17862", "name": "3-ketosphinganine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10684811", "map_id": "Q556J2", "name": "ksrA-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0272883", "map_id": "DDB_G0272883", "name": "ksrA-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693748", "map_id": "none", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024018", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2564836", "map_id": "CHEBI:16507", "name": "I(1,2,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10693563", "map_id": "none", "name": "Homologues of MINPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54ND5", "map_id": "Q54ND5", "name": "mipp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285339", "map_id": "DDB_G0285339", "name": "mipp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L08", "map_id": "Q54L08", "name": "MINPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286993", "map_id": "DDB_G0286993", "name": "MINPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671078", "map_id": "none", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30471", "map_id": "CHEBI:17533", "name": "NAcGlu", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671075", "map_id": "Q54M18", "name": "argC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0286257", "map_id": "DDB_G0286257", "name": "argC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_374064", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10685049", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429773", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429789", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10685046", "map_id": "Q54B63", "name": "SGMS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0293880", "map_id": "DDB_G0293880", "name": "SAMD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703426", "map_id": "none", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668573", "map_id": "CHEBI:29191", "name": "hydroxyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668567", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668577", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662695", "map_id": "CHEBI:16852", "name": "L-Dopaquinone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10703411", "map_id": "none", "name": "TYR:2xCu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10703424", "map_id": "none", "name": "Homologues of SLC45A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "Q7KWK4", "map_id": "Q7KWK4", "name": "SLC45A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276801", "map_id": "DDB_G0276801", "name": "SLC45A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GN9", "map_id": "Q55GN9", "name": "SLC45A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680347", "map_id": "none", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29790", "map_id": "CHEBI:57737", "name": "XY5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671742", "map_id": "none", "name": "RPE:Fe2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YE7", "map_id": "Q54YE7", "name": "rpe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278275", "map_id": "DDB_G0278275", "name": "rpe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671753", "map_id": "none", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671750", "map_id": "Q551C2", "name": "rpiA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0276711", "map_id": "DDB_G0276711", "name": "rpiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726112", "map_id": "none", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30064", "map_id": "CHEBI:17712", "name": "XAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10671880", "map_id": "none", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671860", "map_id": "none", "name": "limit dextrin-glycogenin dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10671872", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10671877", "map_id": "Q54K94", "name": "AGL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287569", "map_id": "DDB_G0287569", "name": "AGL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686823", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686820", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10680968", "map_id": "none", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10680926", "map_id": "none", "name": "eNOS:NOSIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55DU4", "map_id": "Q55DU4", "name": "nosip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270882", "map_id": "DDB_G0270882", "name": "nosip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680966", "map_id": "none", "name": "eNOS:NOSIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10693648", "map_id": "none", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023891", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675760", "map_id": "none", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500088", "map_id": "none", "name": "(d)AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109386", "map_id": "CHEBI:58245", "name": "2'-deoxyadenosine 5'-monophosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10675757", "map_id": "none", "name": "ADK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MB5", "map_id": "Q54MB5", "name": "adk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286057", "map_id": "DDB_G0286057", "name": "adk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671328", "map_id": "none", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70858", "map_id": "CHEBI:27754", "name": "MACR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10670934", "map_id": "none", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670857", "map_id": "none", "name": "PGM:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10673994", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111584", "map_id": "CHEBI:57464", "name": "XMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673991", "map_id": "P32073", "name": "guaA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10709701", "map_id": "none", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692409", "map_id": "CHEBI:196991", "name": "4HPCP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692433", "map_id": "CHEBI:3410", "name": "CXPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10709698", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292270", "map_id": "DDB_G0292270", "name": "comG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695694", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10720506", "map_id": "none", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_29480", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8878387", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10720503", "map_id": "Q54VS7", "name": "mcfK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0280161", "map_id": "DDB_G0280161", "name": "mcfK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696226", "map_id": "none", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265281", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142772", "map_id": "CHEBI:63983", "name": "EXA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696205", "map_id": "none", "name": "ALOX15:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686641", "map_id": "none", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_482807", "map_id": "none", "name": "(d)NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_500739", "map_id": "CHEBI:61555", "name": "dUTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29892", "map_id": "CHEBI:61429", "name": "dGTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_110644", "map_id": "CHEBI:61404", "name": "dATP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30185", "map_id": "CHEBI:61481", "name": "dCTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_30187", "map_id": "CHEBI:37568", "name": "dTTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_482803", "map_id": "none", "name": "(d)NDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:60471", "map_id": "CHEBI:60471", "name": "CHEBI:60471", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58369", "map_id": "CHEBI:58369", "name": "CHEBI:58369", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58595", "map_id": "CHEBI:58595", "name": "CHEBI:58595", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:57667", "map_id": "CHEBI:57667", "name": "CHEBI:57667", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:58593", "map_id": "CHEBI:58593", "name": "CHEBI:58593", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686636", "map_id": "none", "name": "NME4 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10675638", "map_id": "none", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77255", "map_id": "CHEBI:15471", "name": "2-trans-Dodecenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77252", "map_id": "CHEBI:27668", "name": "(S)-3-Hydroxydodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10681876", "map_id": "none", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352030", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351630", "map_id": "CHEBI:17606", "name": "I2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_622410", "map_id": "CHEBI:43451", "name": "HI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351639", "map_id": "CHEBI:27847", "name": "MIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10681873", "map_id": "Q6TMK4", "name": "poxA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0277275", "map_id": "DDB_G0277275", "name": "poxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682157", "map_id": "none", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_217315", "map_id": "CHEBI:50673", "name": "MTZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217320", "map_id": "CHEBI:63828", "name": "MTZ-SOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682154", "map_id": "none", "name": "FMO2:FAD:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54H99", "map_id": "Q54H99", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289931", "map_id": "DDB_G0289931", "name": "FMO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT4", "map_id": "Q54GT4", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT2", "map_id": "Q54GT2", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H02", "map_id": "Q54H02", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AS8", "map_id": "Q55AS8", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT1", "map_id": "Q54GT1", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT0", "map_id": "Q54GT0", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721652", "map_id": "none", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942209", "map_id": "CHEBI:36190", "name": "HXA3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10721649", "map_id": "none", "name": "Homologues of ALOXE3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684867", "map_id": "none", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_9025544", "map_id": "CHEBI:31998", "name": "N-acylphytosphingosine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10684861", "map_id": "Q55D94", "name": "DEGS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269738", "map_id": "DDB_G0269738", "name": "DEGS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695696", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10723999", "map_id": "none", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024873", "map_id": "CHEBI:140225", "name": "16S,17S-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10723957", "map_id": "none", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023644", "map_id": "CHEBI:138542", "name": "(18R)-resolvin E3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10695732", "map_id": "none", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066767", "map_id": "CHEBI:65139", "name": "delta2-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683760", "map_id": "none", "name": "ACOX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10723050", "map_id": "none", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10723047", "map_id": "none", "name": "ME1:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6TU48", "map_id": "Q6TU48", "name": "malA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272524", "map_id": "DDB_G0272524", "name": "malA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671234", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_508182", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29588", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:57762", "map_id": "CHEBI:57762", "name": "CHEBI:57762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_508187", "map_id": "none", "name": "KIC,KMVA,KIV", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28654", "map_id": "CHEBI:28654", "name": "CHEBI:28654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16530", "map_id": "CHEBI:16530", "name": "CHEBI:16530", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17865", "map_id": "CHEBI:17865", "name": "CHEBI:17865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10671231", "map_id": "none", "name": "BCAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N47", "map_id": "Q54N47", "name": "bcaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285509", "map_id": "DDB_G0285509", "name": "bcaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699196", "map_id": "none", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699191", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699193", "map_id": "none", "name": "polyGlc-GYG1:GYS1-a tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674368", "map_id": "none", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10724001", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10671162", "map_id": "none", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671159", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54JP5", "map_id": "Q54JP5", "name": "oatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287913", "map_id": "DDB_G0287913", "name": "oatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686188", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671907", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686186", "map_id": "none", "name": "GYG2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679997", "map_id": "none", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197230", "map_id": "CHEBI:15940", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679994", "map_id": "none", "name": "NAPRT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55G10", "map_id": "Q55G10", "name": "naprt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268472", "map_id": "DDB_G0268472", "name": "naprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723963", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024809", "map_id": "none", "name": "RvD3, RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138649", "map_id": "CHEBI:138649", "name": "CHEBI:138649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138648", "map_id": "CHEBI:138648", "name": "CHEBI:138648", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693754", "map_id": "none", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023892", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10723967", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024479", "map_id": "CHEBI:138602", "name": "7(S)-Hp-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10677343", "map_id": "none", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10677337", "map_id": "none", "name": "AMPK heterotrimer (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10677341", "map_id": "none", "name": "AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10683676", "map_id": "none", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193446", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683673", "map_id": "none", "name": "DAO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10686149", "map_id": "none", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671466", "map_id": "none", "name": "FH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VA2", "map_id": "Q54VA2", "name": "fumH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280495", "map_id": "DDB_G0280495", "name": "fumH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690281", "map_id": "none", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10690061", "map_id": "Q54R90", "name": "MRI1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283309", "map_id": "DDB_G0283309", "name": "MRI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711007", "map_id": "none", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247904", "map_id": "CHEBI:4047", "name": "CysGly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711004", "map_id": "none", "name": "CHAC1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LB6", "map_id": "Q54LB6", "name": "CHAC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286727", "map_id": "DDB_G0286727", "name": "CHAC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681902", "map_id": "none", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352329", "map_id": "CHEBI:15768", "name": "DIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352326", "map_id": "CHEBI:18332", "name": "T4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352036", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10695730", "map_id": "none", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066766", "map_id": "CHEBI:65130", "name": "1-3-hydroxy-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066762", "map_id": "CHEBI:65131", "name": "1-3-oxo-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10683611", "map_id": "none", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_389620", "map_id": "CHEBI:456215", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389573", "map_id": "CHEBI:30616", "name": "ATP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683608", "map_id": "Q76P23", "name": "mcfQ", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0272346", "map_id": "DDB_G0272346", "name": "mcfQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695728", "map_id": "none", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10676860", "map_id": "none", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113748", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113745", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10688234", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29390", "map_id": "CHEBI:18405", "name": "PXLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688227", "map_id": "none", "name": "2xPDXK:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EK9", "map_id": "Q55EK9", "name": "pykA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268628", "map_id": "DDB_G0268628", "name": "pykA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702349", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702346", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54F07", "map_id": "Q54F07", "name": "metK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291179", "map_id": "DDB_G0291179", "name": "metK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VU3", "map_id": "Q54VU3", "name": "MAT2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280135", "map_id": "DDB_G0280135", "name": "MAT2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675481", "map_id": "none", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113555", "map_id": "CHEBI:18276", "name": "H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_39427", "map_id": "CHEBI:46195", "name": "Acetaminophen (TN TYLENOL)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76396", "map_id": "CHEBI:29132", "name": "NABQI", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10683691", "map_id": "none", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389819", "map_id": "CHEBI:16995", "name": "OX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10693572", "map_id": "none", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10710360", "map_id": "none", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696122", "map_id": "CHEBI:52575", "name": "alkylglycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710357", "map_id": "Q550E0", "name": "AGMO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0277137", "map_id": "DDB_G0277137", "name": "AGMO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695709", "map_id": "none", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046059", "map_id": "CHEBI:63539", "name": "EPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046057", "map_id": "CHEBI:63541", "name": "DPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10679396", "map_id": "none", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190157", "map_id": "CHEBI:28766", "name": "URO1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_190128", "map_id": "CHEBI:28607", "name": "COPRO1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679341", "map_id": "none", "name": "2xUROD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DF9", "map_id": "Q54DF9", "name": "hemE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292294", "map_id": "DDB_G0292294", "name": "hemE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681911", "map_id": "none", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351627", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209818", "map_id": "CHEBI:16382", "name": "I-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351628", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10682079", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682076", "map_id": "none", "name": "Cytochrome P450 (CYP2W1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723983", "map_id": "none", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10724034", "map_id": "none", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026915", "map_id": "CHEBI:140268", "name": "RCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10724029", "map_id": "none", "name": "LTC4S trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54GA9", "map_id": "Q54GA9", "name": "mgst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290291", "map_id": "DDB_G0290291", "name": "mgst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10681891", "map_id": "none", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29506", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209849", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10681888", "map_id": "none", "name": "TH:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10681909", "map_id": "none", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352331", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10696183", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10723085", "map_id": "none", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10723082", "map_id": "none", "name": "ME3:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10721602", "map_id": "none", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8941723", "map_id": "CHEBI:34778", "name": "GCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_174384", "map_id": "CHEBI:58052", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158602", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8941725", "map_id": "CHEBI:133667", "name": "GCTN4OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10677038", "map_id": "none", "name": "Homologues of UGT1A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55FY0", "map_id": "Q55FY0", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268544", "map_id": "DDB_G0268544", "name": "UGT1A6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IL5", "map_id": "Q54IL5", "name": "ugt52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288655", "map_id": "DDB_G0288655", "name": "ugt52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX8", "map_id": "Q55FX8", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FB2", "map_id": "Q55FB2", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698339", "map_id": "none", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_199207", "map_id": "CHEBI:15956", "name": "Btn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10698337", "map_id": "none", "name": "ACACA:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54J08", "map_id": "Q54J08", "name": "phospho-accA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674851", "map_id": "none", "name": "Btn-ACACA:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698291", "map_id": "Q54IF5", "name": "HLCS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288791", "map_id": "DDB_G0288791", "name": "HLCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726109", "map_id": "none", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10719211", "map_id": "none", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869365", "map_id": "CHEBI:58527", "name": "NAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10719208", "map_id": "none", "name": "Homologues of NMRK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GNF0", "map_id": "Q9GNF0", "name": "udkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271146", "map_id": "DDB_G0271146", "name": "udkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EL3", "map_id": "Q55EL3", "name": "udkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269034", "map_id": "DDB_G0269034", "name": "udkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723061", "map_id": "none", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10723058", "map_id": "none", "name": "ME2:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10671715", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671712", "map_id": "Q54CJ3", "name": "pgl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292898", "map_id": "DDB_G0292898", "name": "pgl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686653", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686650", "map_id": "none", "name": "CTPS2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671318", "map_id": "none", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70851", "map_id": "CHEBI:15479", "name": "ISB-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10671315", "map_id": "none", "name": "ACAD8 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IM8", "map_id": "Q54IM8", "name": "acad8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288647", "map_id": "DDB_G0288647", "name": "acad8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693615", "map_id": "none", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629756", "map_id": "CHEBI:4170", "name": "Glc6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10693612", "map_id": "none", "name": "ISYNA1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N49", "map_id": "Q54N49", "name": "ino1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285505", "map_id": "DDB_G0285505", "name": "ino1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688232", "map_id": "none", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965053", "map_id": "CHEBI:16709", "name": "PDX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_964952", "map_id": "CHEBI:28803", "name": "PDXP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10698532", "map_id": "none", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698527", "map_id": "Q86KB5", "name": "MMACHC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274205", "map_id": "DDB_G0274205", "name": "MMACHC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10698529", "map_id": "none", "name": "MMACHC:cob(II)alamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KB5", "map_id": "Q86KB5", "name": "MMACHC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723981", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671400", "map_id": "none", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29444", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30176", "map_id": "CHEBI:16927", "name": "SACN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671397", "map_id": "none", "name": "AASS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NG9", "map_id": "Q54NG9", "name": "sdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285267", "map_id": "DDB_G0285267", "name": "sdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682460", "map_id": "none", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10671191", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671188", "map_id": "Q54UF3", "name": "odc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10698522", "map_id": "none", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3076887", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_199238", "map_id": "CHEBI:15956", "name": "Btn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351991", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10698519", "map_id": "Q54WG1", "name": "BTD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10697451", "map_id": "none", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357707", "map_id": "CHEBI:30021", "name": "SeMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357652", "map_id": "CHEBI:9066", "name": "AdoSeMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10678906", "map_id": "none", "name": "MAT1A multimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10696223", "map_id": "none", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142718", "map_id": "CHEBI:15628", "name": "15S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10696220", "map_id": "none", "name": "ALOX15/15B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10700265", "map_id": "none", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3065953", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29582", "map_id": "CHEBI:15956", "name": "Btn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10700262", "map_id": "Q54WG1", "name": "BTD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10693640", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024002", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024016", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10710309", "map_id": "none", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10710306", "map_id": "none", "name": "ADPGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54K22", "map_id": "Q54K22", "name": "ADPGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287631", "map_id": "DDB_G0287631", "name": "ADPGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673698", "map_id": "none", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111628", "map_id": "CHEBI:32814", "name": "N-carb-L-Asp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76630", "map_id": "CHEBI:30864", "name": "(S)-DHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10700271", "map_id": "none", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10700269", "map_id": "none", "name": "ACACB:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10680480", "map_id": "none", "name": "Btn-ACACB:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10723954", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023702", "map_id": "CHEBI:132908", "name": "5(S)-Hp-18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10720818", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680482", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10698619", "map_id": "none", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200665", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10678890", "map_id": "none", "name": "MTRR:MTR(cob(I)alamin)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3159260", "map_id": "CHEBI:15982", "name": "cob(I)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10682098", "map_id": "none", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_213162", "map_id": "CHEBI:9171", "name": "MIND", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_213163", "map_id": "CHEBI:63905", "name": "3MEIN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682088", "map_id": "none", "name": "Cytochrome P450 (CYP2B6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10682458", "map_id": "none", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209937", "map_id": "CHEBI:18332", "name": "T4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_209785", "map_id": "CHEBI:16382", "name": "I-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10682455", "map_id": "Q552Y2", "name": "dio3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0275741", "map_id": "DDB_G0275741", "name": "dio3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680568", "map_id": "none", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10680551", "map_id": "Q86I81", "name": "mcfI", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0271922", "map_id": "DDB_G0271922", "name": "mcfI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679324", "map_id": "none", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189411", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189480", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189478", "map_id": "CHEBI:15435", "name": "PPGEN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10679321", "map_id": "none", "name": "2xCPO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54IA7", "map_id": "Q54IA7", "name": "cpox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288893", "map_id": "DDB_G0288893", "name": "cpox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691612", "map_id": "none", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10696267", "map_id": "none", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162256", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162214", "map_id": "CHEBI:61011", "name": "all-E-10PrP2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10696264", "map_id": "none", "name": "PDSS1/2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VJ9", "map_id": "Q54VJ9", "name": "coq1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280293", "map_id": "DDB_G0280293", "name": "coq1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682136", "map_id": "none", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_159154", "map_id": "CHEBI:41774", "name": "TAM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_217269", "map_id": "CHEBI:63825", "name": "TAMO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682133", "map_id": "none", "name": "FMO1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10680561", "map_id": "none", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_200679", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10680558", "map_id": "Q54CY5", "name": "folC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0292632", "map_id": "DDB_G0292632", "name": "folC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724013", "map_id": "none", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026047", "map_id": "CHEBI:140226", "name": "17(S)-Hp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026034", "map_id": "CHEBI:140248", "name": "7,17-diHp-DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10695777", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065269", "map_id": "CHEBI:63516", "name": "ChEBI:63516 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10684878", "map_id": "none", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10686902", "map_id": "none", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_158471", "map_id": "CHEBI:58339", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686899", "map_id": "Q55DM5", "name": "slc35b2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0269602", "map_id": "DDB_G0269602", "name": "slc35b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671498", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671495", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q8T2T5", "map_id": "Q8T2T5", "name": "sdhC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275115", "map_id": "DDB_G0275115", "name": "sdhC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3X4", "map_id": "Q9U3X4", "name": "sdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280535", "map_id": "DDB_G0280535", "name": "sdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YN1", "map_id": "Q54YN1", "name": "sdhD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278157", "map_id": "DDB_G0278157", "name": "sdhD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CC2", "map_id": "Q55CC2", "name": "sdhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270120", "map_id": "DDB_G0270120", "name": "sdhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696163", "map_id": "none", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162031", "map_id": "none", "name": "HXA3/B3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34784", "map_id": "CHEBI:34784", "name": "CHEBI:34784", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10672066", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10672063", "map_id": "none", "name": "PFKFB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q551Y6", "map_id": "Q551Y6", "name": "PFKFB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276253", "map_id": "DDB_G0276253", "name": "PFKFB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SI2", "map_id": "Q54SI2", "name": "phospho-p-S33-PFKFB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282759", "map_id": "DDB_G0282759", "name": "phospho-p-S33-PFKFB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671912", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671909", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671745", "map_id": "none", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10672030", "map_id": "none", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70958", "map_id": "CHEBI:57292", "name": "SUCC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10672027", "map_id": "none", "name": "SUCLG1:SUCLG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P36967", "map_id": "P36967", "name": "scsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289325", "map_id": "DDB_G0289325", "name": "scsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869S7", "map_id": "Q869S7", "name": "scsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274449", "map_id": "DDB_G0274449", "name": "scsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682478", "map_id": "none", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353113", "map_id": "CHEBI:15625", "name": "dc-AdoMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682475", "map_id": "Q9XY92", "name": "spsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268630", "map_id": "DDB_G0268630", "name": "spsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692500", "map_id": "none", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104997", "map_id": "CHEBI:63850", "name": "Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104995", "map_id": "CHEBI:63851", "name": "GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10675875", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:57566", "map_id": "CHEBI:57566", "name": "CHEBI:57566", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675872", "map_id": "none", "name": "AK5,7,8,9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CT8", "map_id": "Q54CT8", "name": "adkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292730", "map_id": "DDB_G0292730", "name": "adkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QJ9", "map_id": "Q54QJ9", "name": "adkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677058", "map_id": "none", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_159151", "map_id": "CHEBI:16990", "name": "BIL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159160", "map_id": "CHEBI:16427", "name": "BMG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10677053", "map_id": "none", "name": "Homologues of UGT1A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10714825", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6801458", "map_id": "CHEBI:15638", "name": "5,10-methenyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5389850", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10714817", "map_id": "none", "name": "MTHFD2, D2L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10674952", "map_id": "none", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674947", "map_id": "Q54VT8", "name": "gk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280371", "map_id": "DDB_G0280371", "name": "gk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686709", "map_id": "none", "name": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70951", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671421", "map_id": "none", "name": "AADAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54K00", "map_id": "Q54K00", "name": "PXLP-AADAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287711", "map_id": "DDB_G0287711", "name": "PXLP-AADAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722779", "map_id": "none", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787326", "map_id": "CHEBI:11563", "name": "dR1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787328", "map_id": "CHEBI:16132", "name": "dR5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10697437", "map_id": "none", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10697433", "map_id": "none", "name": "FDXR:FAD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KG7", "map_id": "Q54KG7", "name": "fdxr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287353", "map_id": "DDB_G0287353", "name": "fdxr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697431", "map_id": "none", "name": "FDXR:FADH2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10718732", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8866574", "map_id": "CHEBI:61560", "name": "dNTP(4-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866608", "map_id": "CHEBI:18274", "name": "2'-deoxynucleoside", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866567", "map_id": "CHEBI:18036", "name": "PPPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_9668967", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10718729", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B0G107", "map_id": "B0G107", "name": "SAMHD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272484", "map_id": "DDB_G0272484", "name": "SAMHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678919", "map_id": "none", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10678916", "map_id": "none", "name": "GSS:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54E83", "map_id": "Q54E83", "name": "gshB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291756", "map_id": "DDB_G0291756", "name": "gshB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693477", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693474", "map_id": "none", "name": "ITPKA/B/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TI0", "map_id": "Q54TI0", "name": "ITPKB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680035", "map_id": "none", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680032", "map_id": "none", "name": "NADSYN1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ML1", "map_id": "Q54ML1", "name": "nadsyn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285877", "map_id": "DDB_G0285877", "name": "nadsyn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674320", "map_id": "none", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500224", "map_id": "none", "name": "dA, dG, dI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500222", "map_id": "none", "name": "dAMP, dGMP, dIMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:57673", "map_id": "CHEBI:57673", "name": "CHEBI:57673", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9731659", "map_id": "CHEBI:61194", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10674317", "map_id": "none", "name": "DGUOK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54YL2", "map_id": "Q54YL2", "name": "dak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278191", "map_id": "DDB_G0278191", "name": "dak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10695691", "map_id": "none", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046056", "map_id": "CHEBI:27432", "name": "ALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046062", "map_id": "CHEBI:51985", "name": "ALA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10724428", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605595", "map_id": "CHEBI:140917", "name": "Type 1 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605615", "map_id": "CHEBI:140914", "name": "sLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10684911", "map_id": "none", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684908", "map_id": "Q54RV9", "name": "sglA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282819", "map_id": "DDB_G0282819", "name": "sglA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680200", "map_id": "none", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198852", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_198827", "map_id": "CHEBI:58539", "name": "DeHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680197", "map_id": "none", "name": "SLC2A1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54CM5", "map_id": "Q54CM5", "name": "symA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292814", "map_id": "DDB_G0292814", "name": "symA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z55", "map_id": "Q54Z55", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277773", "map_id": "DDB_G0277773", "name": "SLC2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693588", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10693585", "map_id": "Q54J22", "name": "IPPK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10723989", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024765", "map_id": "CHEBI:138642", "name": "7(S)-Hp-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10676821", "map_id": "none", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500606", "map_id": "CHEBI:15760", "name": "TYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500608", "map_id": "CHEBI:15621", "name": "HPHAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676816", "map_id": "none", "name": "MAOB:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10710344", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10710341", "map_id": "none", "name": "ALDH1B1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10723965", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10676025", "map_id": "none", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673723", "map_id": "none", "name": "PRPS1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721370", "map_id": "none", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8936443", "map_id": "CHEBI:47823", "name": "NOHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721367", "map_id": "none", "name": "MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q8MYE6", "map_id": "Q8MYE6", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288165", "map_id": "DDB_G0288165", "name": "MARC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YY9", "map_id": "Q54YY9", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:21437", "map_id": "CHEBI:21437", "name": "CHEBI:21437", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D22", "map_id": "Q55D22", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JB6", "map_id": "Q54JB6", "name": "MARC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674006", "map_id": "none", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674004", "map_id": "none", "name": "IMPDH tetramers:IMPDH inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6832", "map_id": "LigandDisplayForward?ligandId=6832", "name": "LigandDisplayForward?ligandId=6832", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6845", "map_id": "LigandDisplayForward?ligandId=6845", "name": "LigandDisplayForward?ligandId=6845", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6842", "map_id": "LigandDisplayForward?ligandId=6842", "name": "LigandDisplayForward?ligandId=6842", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670908", "map_id": "none", "name": "GALK1 phosphorylates Gal to Gal1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29590", "map_id": "CHEBI:17118", "name": "Gal", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30170", "map_id": "CHEBI:17973", "name": "Gal1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670905", "map_id": "Q54B24", "name": "GALK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0293982", "map_id": "DDB_G0293982", "name": "GALK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693763", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023907", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10724764", "map_id": "none", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724761", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23919", "map_id": "Q23919", "name": "pgmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288483", "map_id": "DDB_G0288483", "name": "pgmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710906", "map_id": "none", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693325", "map_id": "CHEBI:30913", "name": "PPCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6783877", "map_id": "CHEBI:58769", "name": "P6C", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10710903", "map_id": "Q54US8", "name": "PIPOX", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0280851", "map_id": "DDB_G0280851", "name": "PIPOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680546", "map_id": "none", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174404", "map_id": "CHEBI:63907", "name": "5-methyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680543", "map_id": "none", "name": "MTHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X84", "map_id": "Q54X84", "name": "MTHFR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279137", "map_id": "DDB_G0279137", "name": "MTHFR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677056", "map_id": "none", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_159149", "map_id": "CHEBI:18392", "name": "BDG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10688530", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_977329", "map_id": "CHEBI:30933", "name": "3POPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688527", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CQ6", "map_id": "Q55CQ6", "name": "serC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269950", "map_id": "DDB_G0269950", "name": "serC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676802", "map_id": "none", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_30373", "map_id": "CHEBI:18139", "name": "TMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140963", "map_id": "CHEBI:15724", "name": "TMAO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10676799", "map_id": "none", "name": "FMO3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10671798", "map_id": "none", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671558", "map_id": "none", "name": "lipo-aKGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q869Y7", "map_id": "Q869Y7", "name": "odhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275029", "map_id": "DDB_G0275029", "name": "odhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17460", "map_id": "CHEBI:17460", "name": "CHEBI:17460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE4", "map_id": "Q54JE4", "name": "ogdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288127", "map_id": "DDB_G0288127", "name": "ogdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680053", "map_id": "none", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73604", "map_id": "CHEBI:57451", "name": "DHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680048", "map_id": "Q54LA0", "name": "DHFR2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0286755", "map_id": "DDB_G0286755", "name": "DHFR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10715958", "map_id": "none", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809801", "map_id": "CHEBI:85939", "name": "3Z-octenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809800", "map_id": "CHEBI:27537", "name": "2E-octenoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10715955", "map_id": "none", "name": "ECI2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10679114", "map_id": "none", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158466", "map_id": "CHEBI:58343", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679111", "map_id": "Q869K3", "name": "bpnt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10682726", "map_id": "none", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113577", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682723", "map_id": "Q55GE2", "name": "mcfT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0267704", "map_id": "DDB_G0267704", "name": "mcfT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711203", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10711200", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QI7", "map_id": "Q54QI7", "name": "hmgL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283813", "map_id": "DDB_G0283813", "name": "hmgL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704741", "map_id": "none", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162232", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10704738", "map_id": "none", "name": "MIOX:2xFe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GH4", "map_id": "Q54GH4", "name": "miox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290161", "map_id": "DDB_G0290161", "name": "miox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10672020", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10672017", "map_id": "Q54Z60", "name": "acsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277815", "map_id": "DDB_G0277815", "name": "acsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688136", "map_id": "none", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10688120", "map_id": "none", "name": "MOCS3:Zn2+ (red.)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FS0", "map_id": "Q55FS0", "name": "mocs3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267980", "map_id": "DDB_G0267980", "name": "mocs3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10688125", "map_id": "none", "name": "MOCS3-S-S(1-):Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688133", "map_id": "none", "name": "PXLP-K258-NFS1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X04", "map_id": "Q54X04", "name": "nfs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279287", "map_id": "DDB_G0279287", "name": "nfs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709886", "map_id": "none", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693723", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194712", "map_id": "CHEBI:30751", "name": "formate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10709883", "map_id": "none", "name": "ESD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54RL8", "map_id": "Q54RL8", "name": "ESD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283037", "map_id": "DDB_G0283037", "name": "ESD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670844", "map_id": "none", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670841", "map_id": "none", "name": "phosphoPFKFB1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10672002", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10673770", "map_id": "none", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500828", "map_id": "none", "name": "(d)CMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673767", "map_id": "none", "name": "DCK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684957", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10684897", "map_id": "Q55A00", "name": "sppA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0272260", "map_id": "DDB_G0272260", "name": "sppA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722590", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959486", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959490", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10722587", "map_id": "Q54B63", "name": "SAMD8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10676096", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866401", "map_id": "CHEBI:57930", "name": "NDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8866399", "map_id": "CHEBI:73316", "name": "dNDP(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676093", "map_id": "none", "name": "RNR (M1M2B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:29034", "map_id": "CHEBI:29034", "name": "CHEBI:29034", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q71", "map_id": "Q54Q71", "name": "rnrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284071", "map_id": "DDB_G0284071", "name": "rnrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42521", "map_id": "P42521", "name": "rnrB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272616", "map_id": "DDB_G0272616", "name": "rnrB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692454", "map_id": "none", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614518", "map_id": "CHEBI:17482", "name": "L-Cystathionine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10692451", "map_id": "none", "name": "PXLP-CBS tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46794", "map_id": "P46794", "name": "cysB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267386", "map_id": "DDB_G0267386", "name": "cysB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10715520", "map_id": "none", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6808499", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10715517", "map_id": "none", "name": "ADH1L2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10693661", "map_id": "none", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10686703", "map_id": "none", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29896", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70744", "map_id": "CHEBI:15486", "name": "bMC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671265", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KE6", "map_id": "Q54KE6", "name": "mccA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287377", "map_id": "DDB_G0287377", "name": "mccA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2J9", "map_id": "Q8T2J9", "name": "mccb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271960", "map_id": "DDB_G0271960", "name": "mccb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723975", "map_id": "none", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024522", "map_id": "CHEBI:138590", "name": "17(R)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024893", "map_id": "CHEBI:140192", "name": "17R(16)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680223", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680209", "map_id": "none", "name": "CYB5A:heme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q86L22", "map_id": "Q86L22", "name": "cyb5B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277079", "map_id": "DDB_G0277079", "name": "cyb5B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680207", "map_id": "none", "name": "CYB5A:ferriheme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "CHEBI:36144", "map_id": "CHEBI:36144", "name": "CHEBI:36144", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10717979", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10717976", "map_id": "Q552S3", "name": "MANBA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0275917", "map_id": "DDB_G0275917", "name": "MANBA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675545", "map_id": "none", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40795", "map_id": "CHEBI:5615", "name": "HALO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76473", "map_id": "CHEBI:29138", "name": "TFAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76474", "map_id": "CHEBI:47266", "name": "HBr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10724271", "map_id": "none", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10724258", "map_id": "none", "name": "glycogen-GYG1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10724262", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10724268", "map_id": "none", "name": "GAA (70, 76 kDa)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q55D50", "map_id": "Q55D50", "name": "GAA (204-?)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269790", "map_id": "DDB_G0269790", "name": "GAA (204-?)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720745", "map_id": "none", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8876775", "map_id": "CHEBI:18323", "name": "Anserine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10720742", "map_id": "Q54ST2", "name": "CARNMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282239", "map_id": "DDB_G0282239", "name": "CARNMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10692480", "map_id": "none", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10674980", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674977", "map_id": "none", "name": "DGAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10722463", "map_id": "none", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955759", "map_id": "CHEBI:18148", "name": "G1,6BP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670855", "map_id": "none", "name": "PGM2L1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671252", "map_id": "none", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70715", "map_id": "CHEBI:15487", "name": "ISV-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10671249", "map_id": "none", "name": "IVD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W88", "map_id": "Q54W88", "name": "ivdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279827", "map_id": "DDB_G0279827", "name": "ivdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710331", "map_id": "none", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428663", "map_id": "CHEBI:17600", "name": "HXAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710328", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10679372", "map_id": "none", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189466", "map_id": "CHEBI:356416", "name": "dALA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10679369", "map_id": "none", "name": "ALAS1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54UX3", "map_id": "Q54UX3", "name": "hemA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280763", "map_id": "DDB_G0280763", "name": "hemA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10673780", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673777", "map_id": "none", "name": "UCK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T154", "map_id": "Q8T154", "name": "udkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274559", "map_id": "DDB_G0274559", "name": "udkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676863", "map_id": "none", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423605", "map_id": "CHEBI:2504", "name": "AFB1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_159211", "map_id": "CHEBI:30725", "name": "AFXBO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10675474", "map_id": "none", "name": "Homologues of CYP2A6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10673691", "map_id": "none", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76632", "map_id": "CHEBI:30839", "name": "ORO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111629", "map_id": "CHEBI:57538", "name": "OMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10673685", "map_id": "none", "name": "UMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P09556", "map_id": "P09556", "name": "pyr56", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280041", "map_id": "DDB_G0280041", "name": "pyr56", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721497", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10682084", "map_id": "none", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215062", "map_id": "none", "name": "cis-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_2142739", "map_id": "CHEBI:34450", "name": "5,6-EET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682081", "map_id": "none", "name": "Cytochrome P450 (CYP2J2 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10671096", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29514", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671093", "map_id": "none", "name": "ARG1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HV8", "map_id": "Q54HV8", "name": "ARG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289195", "map_id": "DDB_G0289195", "name": "ARG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671707", "map_id": "none", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30487", "map_id": "CHEBI:15793", "name": "3HAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_36027", "map_id": "CHEBI:29044", "name": "ACS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671704", "map_id": "none", "name": "HAAO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S02", "map_id": "Q54S02", "name": "haao", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282743", "map_id": "DDB_G0282743", "name": "haao", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680536", "map_id": "none", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10688230", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964945", "map_id": "CHEBI:16410", "name": "PXA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_965146", "map_id": "CHEBI:18335", "name": "PXAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10696171", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10675538", "map_id": "none", "name": "Homologues of CYP2J2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10711236", "map_id": "none", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788802", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_6788801", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10711233", "map_id": "Q54CT8", "name": "adkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10723036", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10723033", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86I22", "map_id": "Q86I22", "name": "fahd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275071", "map_id": "DDB_G0275071", "name": "fahd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699305", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699303", "map_id": "none", "name": "hCBXs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T131", "map_id": "Q8T131", "name": "PCCB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276341", "map_id": "DDB_G0276341", "name": "PCCB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553S7", "map_id": "Q553S7", "name": "pccA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275355", "map_id": "DDB_G0275355", "name": "pccA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698514", "map_id": "none", "name": "hCBXs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10695735", "map_id": "none", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193514", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_353123", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066765", "map_id": "CHEBI:65132", "name": "DHA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683747", "map_id": "Q86IY4", "name": "ACAA1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0274339", "map_id": "DDB_G0274339", "name": "ACAA1(1-424)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671459", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671456", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q553V1", "map_id": "Q553V1", "name": "cs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275311", "map_id": "DDB_G0275311", "name": "cs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722403", "map_id": "none", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722400", "map_id": "Q55EL3", "name": "udkA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10686147", "map_id": "none", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671446", "map_id": "Q54XS2", "name": "aco2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0278779", "map_id": "DDB_G0278779", "name": "aco2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683581", "map_id": "none", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683578", "map_id": "none", "name": "ALDH3A2-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54DG1", "map_id": "Q54DG1", "name": "comG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724011", "map_id": "none", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026050", "map_id": "CHEBI:140234", "name": "7,8-epoxy,17-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10724015", "map_id": "none", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026046", "map_id": "CHEBI:140224", "name": "16(S),17(S)-epoxy-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10690348", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10690324", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54FN9", "map_id": "Q54FN9", "name": "lyrm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290725", "map_id": "DDB_G0290725", "name": "lyrm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C45", "map_id": "Q54C45", "name": "fxn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293246", "map_id": "DDB_G0293246", "name": "fxn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RP2", "map_id": "Q54RP2", "name": "ISCU-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283003", "map_id": "DDB_G0283003", "name": "ISCU-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690337", "map_id": "none", "name": "FDX1,FDX2 (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GW1", "map_id": "Q55GW1", "name": "FDX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267486", "map_id": "DDB_G0267486", "name": "FDX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690345", "map_id": "none", "name": "FDX1,FDX2 (oxidized)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690339", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10693736", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693733", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10721406", "map_id": "none", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938276", "map_id": "CHEBI:133202", "name": "(ADP-D-ribosyl)(n)-acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8938282", "map_id": "CHEBI:133203", "name": "(ADP-D-ribosyl)(n+1)-acceptor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721403", "map_id": "none", "name": "PARPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JP6", "map_id": "Q54JP6", "name": "PARP16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287911", "map_id": "DDB_G0287911", "name": "PARP16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725648", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10678991", "map_id": "none", "name": "Homologues of GSTA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725644", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693623", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023922", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10693523", "map_id": "none", "name": "IP6K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10696160", "map_id": "none", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9032038", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161856", "map_id": "none", "name": "LXA4/B4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:6498", "map_id": "CHEBI:6498", "name": "CHEBI:6498", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6499", "map_id": "CHEBI:6499", "name": "CHEBI:6499", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10715539", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10715536", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671308", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10682018", "map_id": "none", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211906", "map_id": "CHEBI:45863", "name": "PTXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211894", "map_id": "CHEBI:63859", "name": "HPTXL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10693580", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693577", "map_id": "none", "name": "INPP5(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10688160", "map_id": "none", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947703", "map_id": "CHEBI:17319", "name": "dADE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947537", "map_id": "CHEBI:59648", "name": "Precursor Z", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688157", "map_id": "none", "name": "holo-MOCS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NM6", "map_id": "Q54NM6", "name": "mocs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285137", "map_id": "DDB_G0285137", "name": "mocs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710887", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710884", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MR1", "map_id": "Q54MR1", "name": "hagh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285717", "map_id": "DDB_G0285717", "name": "hagh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724005", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024989", "map_id": "CHEBI:140196", "name": "7(S),14(S)-diHp-DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675640", "map_id": "none", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77313", "map_id": "CHEBI:15473", "name": "Crotonoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77251", "map_id": "CHEBI:15453", "name": "3HB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10687061", "map_id": "none", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10687058", "map_id": "Q54GJ7", "name": "adhfe1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0290111", "map_id": "DDB_G0290111", "name": "adhfe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685398", "map_id": "none", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685395", "map_id": "none", "name": "Homologues of 4xPalmC-CD36", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10676087", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676084", "map_id": "none", "name": "RNR (M1M2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684832", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684819", "map_id": "Q54S87", "name": "crsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282607", "map_id": "DDB_G0282607", "name": "crsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680564", "map_id": "none", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671362", "map_id": "none", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30721", "map_id": "CHEBI:30817", "name": "UCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671359", "map_id": "Q556V9", "name": "HAL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0273081", "map_id": "DDB_G0273081", "name": "HAL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673986", "map_id": "none", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500071", "map_id": "none", "name": "(d)GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500077", "map_id": "none", "name": "(d)GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674020", "map_id": "none", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111409", "map_id": "CHEBI:58475", "name": "AICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_419151", "map_id": "CHEBI:57454", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10671380", "map_id": "none", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34979", "map_id": "CHEBI:27384", "name": "4I-5PROA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671377", "map_id": "Q55CY3", "name": "amdhd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269854", "map_id": "DDB_G0269854", "name": "amdhd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716922", "map_id": "none", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10716918", "map_id": "Q54GC8", "name": "acbd6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290237", "map_id": "DDB_G0290237", "name": "acbd6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716920", "map_id": "none", "name": "ACBD6:LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GC8", "map_id": "Q54GC8", "name": "acbd6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674856", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674853", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10710920", "map_id": "none", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35305", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113538", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710917", "map_id": "none", "name": "PYCRL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IL7", "map_id": "Q54IL7", "name": "pycr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288671", "map_id": "DDB_G0288671", "name": "pycr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671686", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671683", "map_id": "Q54RE8", "name": "kmo", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283173", "map_id": "DDB_G0283173", "name": "kmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724728", "map_id": "none", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10724725", "map_id": "none", "name": "UGT1A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10671619", "map_id": "none", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671616", "map_id": "none", "name": "TAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K95", "map_id": "Q54K95", "name": "tat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287515", "map_id": "DDB_G0287515", "name": "tat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714942", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714939", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671106", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10693575", "map_id": "none", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10711211", "map_id": "none", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788606", "map_id": "CHEBI:60175", "name": "5HLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696409", "map_id": "CHEBI:16752", "name": "5PHL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10711208", "map_id": "C7G071", "name": "HYKK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0295739", "map_id": "DDB_G0295739", "name": "HYKK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671608", "map_id": "none", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71129", "map_id": "CHEBI:20680", "name": "qDHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671605", "map_id": "none", "name": "PCBD1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XF6", "map_id": "Q54XF6", "name": "PCBD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278993", "map_id": "DDB_G0278993", "name": "PCBD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RY8", "map_id": "Q54RY8", "name": "pcbd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282831", "map_id": "DDB_G0282831", "name": "pcbd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674301", "map_id": "none", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10674298", "map_id": "none", "name": "OXCT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54JD9", "map_id": "Q54JD9", "name": "oxct1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288105", "map_id": "DDB_G0288105", "name": "oxct1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693708", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10693705", "map_id": "none", "name": "INPP5(3)/ITPK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679054", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34718", "map_id": "CHEBI:34718", "name": "CHEBI:34718", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9753685", "map_id": "CHEBI:32639", "name": "APAP-SG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:8927", "map_id": "CHEBI:8927", "name": "CHEBI:8927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679051", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JU2", "map_id": "Q54JU2", "name": "GSTT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293122", "map_id": "DDB_G0293122", "name": "GSTT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C73", "map_id": "Q54C73", "name": "GSTT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671539", "map_id": "none", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671536", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10680025", "map_id": "none", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197238", "map_id": "CHEBI:29959", "name": "QUIN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680022", "map_id": "Q75JX0", "name": "qprt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272462", "map_id": "DDB_G0272462", "name": "qprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683763", "map_id": "none", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10685044", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10685041", "map_id": "Q54B63", "name": "2xPalmC-SGMS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10725886", "map_id": "none", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684851", "map_id": "none", "name": "Homologues of SPHK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725884", "map_id": "none", "name": "SPHK2:SPHK2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6625", "map_id": "LigandDisplayForward?ligandId=6625", "name": "LigandDisplayForward?ligandId=6625", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10641", "map_id": "LigandDisplayForward?ligandId=10641", "name": "LigandDisplayForward?ligandId=10641", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10219", "map_id": "LigandDisplayForward?ligandId=10219", "name": "LigandDisplayForward?ligandId=10219", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6624", "map_id": "LigandDisplayForward?ligandId=6624", "name": "LigandDisplayForward?ligandId=6624", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687082", "map_id": "none", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_893607", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_893617", "map_id": "CHEBI:17442", "name": "APDBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10725836", "map_id": "none", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678719", "map_id": "none", "name": "IMPDH inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686178", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_374061", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10686175", "map_id": "none", "name": "ARG2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10676068", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:57567", "name": "ADS", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676065", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P21900", "map_id": "P21900", "name": "purA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285429", "map_id": "DDB_G0285429", "name": "purA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697789", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:61382", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10710603", "map_id": "none", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6801451", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10710600", "map_id": "none", "name": "MTHFD1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10679344", "map_id": "none", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189407", "map_id": "CHEBI:15437", "name": "URO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189455", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679938", "map_id": "none", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196786", "map_id": "CHEBI:15905", "name": "PPanK", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679935", "map_id": "none", "name": "2xPPCS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S85", "map_id": "Q54S85", "name": "PPCS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282611", "map_id": "DDB_G0282611", "name": "PPCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724017", "map_id": "none", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10686496", "map_id": "none", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_482625", "map_id": "none", "name": "(d)NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_482627", "map_id": "none", "name": "(d)NDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674365", "map_id": "none", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10674362", "map_id": "none", "name": "GDA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AW9", "map_id": "Q86AW9", "name": "guaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277743", "map_id": "DDB_G0277743", "name": "guaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696240", "map_id": "none", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162212", "map_id": "CHEBI:64182", "name": "DeMQ10H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162198", "map_id": "CHEBI:64183", "name": "Q10H2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10696237", "map_id": "Q54XD0", "name": "coq3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0279037", "map_id": "DDB_G0279037", "name": "coq3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723961", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024574", "map_id": "none", "name": "AT-RvD1, AT-RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138179", "map_id": "CHEBI:138179", "name": "CHEBI:138179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138614", "map_id": "CHEBI:138614", "name": "CHEBI:138614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680508", "map_id": "none", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_200492", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_200499", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10680505", "map_id": "none", "name": "6xNMNAT1:6xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10671648", "map_id": "none", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671645", "map_id": "none", "name": "HGD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QI4", "map_id": "Q54QI4", "name": "hgd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283765", "map_id": "DDB_G0283765", "name": "hgd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687814", "map_id": "none", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10687811", "map_id": "none", "name": "ABCG2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86HQ2", "map_id": "Q86HQ2", "name": "abcG8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274117", "map_id": "DDB_G0274117", "name": "abcG8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T685", "map_id": "Q8T685", "name": "abcG12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274115", "map_id": "DDB_G0274115", "name": "abcG12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T689", "map_id": "Q8T689", "name": "abcG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289657", "map_id": "DDB_G0289657", "name": "abcG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DA0", "map_id": "Q55DA0", "name": "abcG22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270826", "map_id": "DDB_G0270826", "name": "abcG22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T686", "map_id": "Q8T686", "name": "abcG7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289655", "map_id": "DDB_G0289655", "name": "abcG7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723987", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024576", "map_id": "CHEBI:138601", "name": "4(S)-Hp-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675483", "map_id": "none", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_31711", "map_id": "CHEBI:16716", "name": "C6H6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29630", "map_id": "CHEBI:15882", "name": "PhOH", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10696181", "map_id": "none", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682252", "map_id": "none", "name": "ALOX5:ALOX5AP:LTC4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10698333", "map_id": "none", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698327", "map_id": "none", "name": "6xMCCC1:6xMCCC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698331", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693566", "map_id": "none", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024008", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024012", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10688246", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10688241", "map_id": "none", "name": "2xPNPO:2xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YS6", "map_id": "Q54YS6", "name": "pnpo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278107", "map_id": "DDB_G0278107", "name": "pnpo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690084", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10690081", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM6", "map_id": "Q55FM6", "name": "enoph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268036", "map_id": "DDB_G0268036", "name": "enoph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675840", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10675837", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680494", "map_id": "none", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680489", "map_id": "none", "name": "Btn-p-S79-ACACB:2Mn2+ polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10680491", "map_id": "none", "name": "AMPK heterotrimer (active)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671278", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70784", "map_id": "CHEBI:43074", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671275", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54HG7", "map_id": "Q54HG7", "name": "auh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289471", "map_id": "DDB_G0289471", "name": "auh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671403", "map_id": "none", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10696251", "map_id": "none", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162209", "map_id": "CHEBI:50775", "name": "DHDB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162215", "map_id": "CHEBI:50776", "name": "MHDB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10684875", "map_id": "none", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3632878", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428237", "map_id": "CHEBI:46961", "name": "phytosphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10684872", "map_id": "Q6TMJ1", "name": "dcd3A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0288359", "map_id": "DDB_G0288359", "name": "dcd3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675569", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10675566", "map_id": "none", "name": "AMPD tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DD0", "map_id": "Q54DD0", "name": "amdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292266", "map_id": "DDB_G0292266", "name": "amdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680928", "map_id": "none", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680924", "map_id": "Q55DU4", "name": "nosip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10714820", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10714931", "map_id": "none", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_6806891", "map_id": "CHEBI:28869", "name": "menadione", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806657", "map_id": "CHEBI:57533", "name": "GGPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806656", "map_id": "CHEBI:33019", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806362", "map_id": "CHEBI:78277", "name": "MK4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10714928", "map_id": "Q54K99", "name": "ubiad1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0287509", "map_id": "DDB_G0287509", "name": "ubiad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675642", "map_id": "none", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77324", "map_id": "CHEBI:28706", "name": "trans-Hex-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77322", "map_id": "CHEBI:28276", "name": "(S)-Hydroxyhexanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10678909", "map_id": "none", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10695699", "map_id": "none", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046065", "map_id": "CHEBI:63543", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10671354", "map_id": "none", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671351", "map_id": "Q54I10", "name": "mmsdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0289085", "map_id": "DDB_G0289085", "name": "mmsdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673701", "map_id": "none", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10673688", "map_id": "none", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680051", "map_id": "none", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197965", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10722428", "map_id": "none", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8954466", "map_id": "CHEBI:21547", "name": "NAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10722425", "map_id": "none", "name": "Homologues of NAT8L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54BP5", "map_id": "Q54BP5", "name": "NAT8L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293514", "map_id": "DDB_G0293514", "name": "NAT8L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IG0", "map_id": "Q54IG0", "name": "NAT8L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687093", "map_id": "none", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29502", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_893599", "map_id": "CHEBI:29750", "name": "3IN-PYRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687090", "map_id": "none", "name": "PXLP-KYAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KM6", "map_id": "Q54KM6", "name": "ccbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287269", "map_id": "DDB_G0287269", "name": "ccbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725642", "map_id": "none", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5679042", "map_id": "none", "name": "BMG,BDG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5679034", "map_id": "none", "name": "BMG,BDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10680501", "map_id": "none", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8938083", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938090", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10680498", "map_id": "none", "name": "4xNMNAT3:4xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10698629", "map_id": "none", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159297", "map_id": "CHEBI:18408", "name": "AdoCbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3159274", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10698626", "map_id": "none", "name": "3xMMAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W51", "map_id": "Q54W51", "name": "MMAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279905", "map_id": "DDB_G0279905", "name": "MMAB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696138", "map_id": "none", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2160466", "map_id": "CHEBI:18005", "name": "kPPV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10696135", "map_id": "none", "name": "IL4I1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54EW2", "map_id": "Q54EW2", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293662", "map_id": "DDB_G0293662", "name": "IL4I1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BE7", "map_id": "Q54BE7", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55B17", "map_id": "Q55B17", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55B19", "map_id": "Q55B19", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723979", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024570", "map_id": "none", "name": "AT-RvD3, AT-RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138616", "map_id": "CHEBI:138616", "name": "CHEBI:138616", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138615", "map_id": "CHEBI:138615", "name": "CHEBI:138615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679334", "map_id": "none", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189463", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10679331", "map_id": "none", "name": "2xPPOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54DT8", "map_id": "Q54DT8", "name": "ppox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292040", "map_id": "DDB_G0292040", "name": "ppox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671581", "map_id": "none", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671578", "map_id": "none", "name": "PAH:Fe2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10690353", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10690351", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10690098", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10690095", "map_id": "none", "name": "CNDP2:2Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X02", "map_id": "Q54X02", "name": "CNDP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279291", "map_id": "DDB_G0279291", "name": "CNDP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693526", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10711146", "map_id": "none", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6787810", "map_id": "CHEBI:65101", "name": "2OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6787814", "map_id": "CHEBI:86988", "name": "2oxo-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10711143", "map_id": "none", "name": "HAO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10699208", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699203", "map_id": "none", "name": "GYG1:GYS1-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10709111", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:59554", "map_id": "CHEBI:59554", "name": "CHEBI:59554", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10709108", "map_id": "none", "name": "ACOT2,9, THEM4,5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54LP9", "map_id": "Q54LP9", "name": "ACOT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286507", "map_id": "DDB_G0286507", "name": "ACOT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703158", "map_id": "none", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10703155", "map_id": "none", "name": "SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10712054", "map_id": "none", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6798162", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10712051", "map_id": "none", "name": "Homologues of SLC44A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10693739", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693673", "map_id": "none", "name": "Homologues of INPP5B(321-993)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54PV1", "map_id": "Q54PV1", "name": "Dd5P2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284187", "map_id": "DDB_G0284187", "name": "Dd5P2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693417", "map_id": "none", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104993", "map_id": "CHEBI:63868", "name": "CHEBI:63868 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10699242", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699240", "map_id": "none", "name": "glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10699218", "map_id": "Q555Q9", "name": "glgB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274105", "map_id": "DDB_G0274105", "name": "glgB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704832", "map_id": "none", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10691218", "map_id": "none", "name": "Homologues of ABCC2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724243", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671571", "map_id": "none", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70955", "map_id": "CHEBI:15524", "name": "GL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71045", "map_id": "CHEBI:15473", "name": "crotonyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671568", "map_id": "none", "name": "GCDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54R47", "map_id": "Q54R47", "name": "gcdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283411", "map_id": "DDB_G0283411", "name": "gcdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684954", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684951", "map_id": "none", "name": "PPAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MXL9", "map_id": "Q8MXL9", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284367", "map_id": "DDB_G0284367", "name": "PPAP2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AF0", "map_id": "Q86AF0", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PR7", "map_id": "Q54PR7", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679354", "map_id": "none", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189489", "map_id": "CHEBI:356416", "name": "dALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189464", "map_id": "CHEBI:58126", "name": "PBG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679351", "map_id": "none", "name": "8x(ALAD:Zn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55E06", "map_id": "Q55E06", "name": "alad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269444", "map_id": "DDB_G0269444", "name": "alad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698535", "map_id": "none", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000125", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10682318", "map_id": "none", "name": "Homologues of ABCC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10687096", "map_id": "none", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893615", "map_id": "CHEBI:17442", "name": "AP-DOBu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8939576", "map_id": "none", "name": "I3LACT, I3PROPA", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:55528", "map_id": "CHEBI:55528", "name": "CHEBI:55528", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:43580", "map_id": "CHEBI:43580", "name": "CHEBI:43580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724430", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605649", "map_id": "CHEBI:140919", "name": "Type 1 DSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605651", "map_id": "CHEBI:140915", "name": "dsLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10671336", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671333", "map_id": "Q55GS6", "name": "hibch", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0267536", "map_id": "DDB_G0267536", "name": "hibch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682091", "map_id": "none", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211977", "map_id": "CHEBI:4026", "name": "CPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211967", "map_id": "CHEBI:1864", "name": "HCPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10681868", "map_id": "none", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10681865", "map_id": "none", "name": "DIO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q552Y2", "map_id": "Q552Y2", "name": "dio3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688113", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688110", "map_id": "Q559G8", "name": "mocos", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272935", "map_id": "DDB_G0272935", "name": "mocos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690074", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10690071", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ER6", "map_id": "Q54ER6", "name": "adi1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291376", "map_id": "DDB_G0291376", "name": "adi1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671127", "map_id": "none", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29642", "map_id": "CHEBI:58048", "name": "L-Asn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671124", "map_id": "none", "name": "ASNS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MB4", "map_id": "Q54MB4", "name": "asns", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286059", "map_id": "DDB_G0286059", "name": "asns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699238", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699235", "map_id": "none", "name": "GYG2:GYS2-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703431", "map_id": "none", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662708", "map_id": "none", "name": "DHI, DHICA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "CHEBI:27404", "map_id": "CHEBI:27404", "name": "CHEBI:27404", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5662678", "map_id": "none", "name": "Eumelanin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "species_5668568", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "reaction_10671796", "map_id": "none", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671793", "map_id": "none", "name": "lipo-PDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54C70", "map_id": "Q54C70", "name": "pdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292994", "map_id": "DDB_G0292994", "name": "pdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AD5", "map_id": "Q86AD5", "name": "pdhX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271564", "map_id": "DDB_G0271564", "name": "pdhX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HX0", "map_id": "Q86HX0", "name": "pdhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276417", "map_id": "DDB_G0276417", "name": "pdhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36413", "map_id": "P36413", "name": "pdhC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277847", "map_id": "DDB_G0277847", "name": "pdhC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674059", "map_id": "none", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73917", "map_id": "CHEBI:15467", "name": "HMG CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10674056", "map_id": "none", "name": "Homologues of HMGCS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P54872", "map_id": "P54872", "name": "hgsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288461", "map_id": "DDB_G0288461", "name": "hgsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HL5", "map_id": "Q86HL5", "name": "hgsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709082", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10709079", "map_id": "none", "name": "ACOT13 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C7G041", "map_id": "C7G041", "name": "ACOT13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295733", "map_id": "DDB_G0295733", "name": "ACOT13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686145", "map_id": "none", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5462", "compartment_display": "mitochondrion" }, { "id": "species_10686142", "map_id": "none", "name": "NNT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q55F30", "map_id": "Q55F30", "name": "NNT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269046", "map_id": "DDB_G0269046", "name": "NNT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722332", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8953493", "map_id": "CHEBI:456215", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10722329", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10671932", "map_id": "none", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671929", "map_id": "none", "name": "pyruvate kinase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RF5", "map_id": "Q54RF5", "name": "pyk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283247", "map_id": "DDB_G0283247", "name": "pyk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680528", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10682074", "map_id": "none", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211993", "map_id": "CHEBI:34665", "name": "DSQ", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_211952", "map_id": "CHEBI:63800", "name": "HDBQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10671151", "map_id": "none", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113567", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671148", "map_id": "none", "name": "Homologues of SLC25A15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54FE6", "map_id": "Q54FE6", "name": "mcfS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290913", "map_id": "DDB_G0290913", "name": "mcfS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HN8", "map_id": "Q86HN8", "name": "mcfY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274501", "map_id": "DDB_G0274501", "name": "mcfY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E85", "map_id": "Q55E85", "name": "mcfD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269352", "map_id": "DDB_G0269352", "name": "mcfD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676819", "map_id": "none", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500605", "map_id": "CHEBI:18397", "name": "PEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500607", "map_id": "CHEBI:16424", "name": "Phenylacetaldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10710913", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10710910", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10724046", "map_id": "none", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9028274", "map_id": "CHEBI:72623", "name": "7-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10678893", "map_id": "none", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10724009", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025960", "map_id": "CHEBI:140218", "name": "14(S)-HDPAn-6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10683603", "map_id": "none", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389615", "map_id": "CHEBI:15538", "name": "Phytanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389594", "map_id": "CHEBI:15475", "name": "3S2HPhy-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389583", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683600", "map_id": "none", "name": "PHYH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54SF6", "map_id": "Q54SF6", "name": "PHYH(1-338)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282495", "map_id": "DDB_G0282495", "name": "PHYH(1-338)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703429", "map_id": "none", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "reaction_10684902", "map_id": "none", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428694", "map_id": "CHEBI:16566", "name": "SPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10674338", "map_id": "none", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671372", "map_id": "none", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671369", "map_id": "none", "name": "UROC1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AX3", "map_id": "Q86AX3", "name": "uroc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277727", "map_id": "DDB_G0277727", "name": "uroc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723950", "map_id": "none", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10671172", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671169", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10682291", "map_id": "none", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_266010", "map_id": "CHEBI:15632", "name": "5S-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673806", "map_id": "none", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83928", "map_id": "CHEBI:17748", "name": "Thy-dRib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:63528", "name": "TMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10673803", "map_id": "none", "name": "TK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27564", "map_id": "Q27564", "name": "thyB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289179", "map_id": "DDB_G0289179", "name": "thyB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671561", "map_id": "none", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10720454", "map_id": "none", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720450", "map_id": "none", "name": "TTPA:alpha-TOH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_8874708", "map_id": "CHEBI:18145", "name": "alpha-TOH", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q54YX3", "map_id": "Q54YX3", "name": "RLBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278031", "map_id": "DDB_G0278031", "name": "RLBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10720452", "map_id": "none", "name": "TTPA:alpha-TOH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10721392", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721389", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693651", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023940", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10699221", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699213", "map_id": "none", "name": "glycogen-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674042", "map_id": "none", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:58681", "name": "PRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111338", "map_id": "CHEBI:143788", "name": "PRGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674025", "map_id": "Q54GJ2", "name": "purD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290121", "map_id": "DDB_G0290121", "name": "purD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697435", "map_id": "none", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10701681", "map_id": "none", "name": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000239", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10701678", "map_id": "none", "name": "ABCD4:LMBRD1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54W20", "map_id": "Q54W20", "name": "abcD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279919", "map_id": "DDB_G0279919", "name": "abcD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KD1", "map_id": "Q54KD1", "name": "lmbrd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287405", "map_id": "DDB_G0287405", "name": "lmbrd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714347", "map_id": "none", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6799577", "map_id": "CHEBI:91279", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10714344", "map_id": "none", "name": "MAN2B2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q1ZXI8", "map_id": "Q1ZXI8", "name": "manE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278651", "map_id": "DDB_G0278651", "name": "manE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ER0", "map_id": "Q55ER0", "name": "manC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268994", "map_id": "DDB_G0268994", "name": "manC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KN4", "map_id": "Q54KN4", "name": "manF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287231", "map_id": "DDB_G0287231", "name": "manF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YF7", "map_id": "Q54YF7", "name": "manB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278259", "map_id": "DDB_G0278259", "name": "manB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YC4", "map_id": "Q54YC4", "name": "manD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278653", "map_id": "DDB_G0278653", "name": "manD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34098", "map_id": "P34098", "name": "manA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292206", "map_id": "DDB_G0292206", "name": "manA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724753", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10682086", "map_id": "none", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211855", "map_id": "CHEBI:27999", "name": "TBM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211937", "map_id": "CHEBI:63799", "name": "HTOLB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10671697", "map_id": "none", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671694", "map_id": "none", "name": "KYNU dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Q04", "map_id": "Q54Q04", "name": "kynu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284203", "map_id": "DDB_G0284203", "name": "kynu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679394", "map_id": "none", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190173", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10679392", "map_id": "none", "name": "8xALAD:Pb2+:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699256", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699253", "map_id": "none", "name": "GYG1:GYS1-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10696176", "map_id": "none", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10696173", "map_id": "none", "name": "CYP(5)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10724757", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2105012", "map_id": "CHEBI:63852", "name": "GlcNAc-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105010", "map_id": "CHEBI:63853", "name": "Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10724423", "map_id": "none", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9033790", "map_id": "CHEBI:139350", "name": "Type 2 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605593", "map_id": "CHEBI:140911", "name": "LeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10724420", "map_id": "none", "name": "FUT4,5,9(10,11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10675485", "map_id": "none", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40887", "map_id": "CHEBI:27385", "name": "CCl4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76433", "map_id": "none", "name": "Trichloromethyl radical", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29572", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10671513", "map_id": "none", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671510", "map_id": "none", "name": "SUCLA2:SUCLG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55AI5", "map_id": "Q55AI5", "name": "scsC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271842", "map_id": "DDB_G0271842", "name": "scsC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710932", "map_id": "none", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784236", "map_id": "CHEBI:32812", "name": "4-OH-L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10696197", "map_id": "none", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10696194", "map_id": "none", "name": "ALOX12B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678954", "map_id": "none", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_174932", "map_id": "none", "name": "N-centre functional group substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:17688", "map_id": "CHEBI:17688", "name": "CHEBI:17688", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_174918", "map_id": "none", "name": "N-glucuronide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:32663", "map_id": "CHEBI:32663", "name": "CHEBI:32663", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63860", "map_id": "CHEBI:63860", "name": "CHEBI:63860", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678951", "map_id": "none", "name": "UGT1A3,A4,A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10714406", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10714399", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10684913", "map_id": "none", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10709894", "map_id": "none", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5693768", "map_id": "CHEBI:85781", "name": "2HCERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10709891", "map_id": "Q55CT7", "name": "FA2H", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269908", "map_id": "DDB_G0269908", "name": "FA2H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671086", "map_id": "none", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29676", "map_id": "CHEBI:58228", "name": "CAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671083", "map_id": "P20054", "name": "pyr1-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10716029", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10716026", "map_id": "Q54GC2", "name": "NUDT19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0290277", "map_id": "DDB_G0290277", "name": "NUDT19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674970", "map_id": "none", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674967", "map_id": "none", "name": "LPIN1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10685912", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10685909", "map_id": "Q54Z60", "name": "acsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10690108", "map_id": "none", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10690105", "map_id": "none", "name": "OPLAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NW6", "map_id": "Q54NW6", "name": "oplah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284953", "map_id": "DDB_G0284953", "name": "oplah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682289", "map_id": "none", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_266066", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680220", "map_id": "none", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680217", "map_id": "none", "name": "CYB5R3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10682255", "map_id": "none", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10712062", "map_id": "none", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9757044", "map_id": "CHEBI:13193", "name": "hydrogen acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9757039", "map_id": "CHEBI:17499", "name": "hydrogen donor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10712059", "map_id": "B0G160", "name": "chdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0287229", "map_id": "DDB_G0287229", "name": "chdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687099", "map_id": "none", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893598", "map_id": "CHEBI:30882", "name": "2OGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673790", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673787", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I82", "map_id": "Q54I82", "name": "cda", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288933", "map_id": "DDB_G0288933", "name": "cda", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10706110", "map_id": "none", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5689006", "map_id": "CHEBI:8050", "name": "PHEN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5688995", "map_id": "CHEBI:85505", "name": "4-ethoxyaniline", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5689001", "map_id": "CHEBI:40574", "name": "acetyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10706107", "map_id": "Q54QI3", "name": "AADAC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0283819", "map_id": "DDB_G0283819", "name": "NCEH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693680", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10693677", "map_id": "none", "name": "Inositol polyphosphate 5-phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10692503", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10682468", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682465", "map_id": "Q54W72", "name": "SAT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279851", "map_id": "DDB_G0279851", "name": "SAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724731", "map_id": "none", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10677009", "map_id": "Q54IL5", "name": "ugt52", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10671242", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508190", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_508181", "map_id": "none", "name": "KIC, KMVA, KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10671239", "map_id": "none", "name": "BCAT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10683593", "map_id": "none", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389578", "map_id": "CHEBI:15522", "name": "FOR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683590", "map_id": "none", "name": "HACL1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54DA9", "map_id": "Q54DA9", "name": "hacl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292402", "map_id": "DDB_G0292402", "name": "hacl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693745", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023941", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10671995", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671992", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10671638", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671635", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q76NV5", "map_id": "Q76NV5", "name": "hpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277511", "map_id": "DDB_G0277511", "name": "hpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557J8", "map_id": "Q557J8", "name": "hpdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273429", "map_id": "DDB_G0273429", "name": "hpdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698616", "map_id": "none", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3149505", "map_id": "CHEBI:17439", "name": "CNCbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1130611", "map_id": "CHEBI:18407", "name": "HCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10702271", "map_id": "none", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423629", "map_id": "CHEBI:78576", "name": "AFM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5423657", "map_id": "CHEBI:78577", "name": "AFM1E", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10719223", "map_id": "none", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869377", "map_id": "CHEBI:15927", "name": "NR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10719217", "map_id": "none", "name": "Homologues of NMRK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10714960", "map_id": "none", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10714957", "map_id": "Q54FJ9", "name": "CARKD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0290799", "map_id": "DDB_G0290799", "name": "CARKD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10675877", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10687069", "map_id": "none", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10687066", "map_id": "Q55E52", "name": "D2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0270500", "map_id": "DDB_G0270500", "name": "D2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_880069", "map_id": "CHEBI:27638", "name": "Co2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113527", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880067", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10724039", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10724036", "map_id": "none", "name": "CYP1A2,2C8,2C9,2D6,2E1,3A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10696186", "map_id": "none", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142745", "map_id": "CHEBI:34151", "name": "12-oxoETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10688519", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10688516", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ES3", "map_id": "Q54ES3", "name": "serB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291368", "map_id": "DDB_G0291368", "name": "serB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674355", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674352", "map_id": "none", "name": "NT5C2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JY6", "map_id": "Q54JY6", "name": "NT5C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287735", "map_id": "DDB_G0287735", "name": "NT5C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XC1", "map_id": "Q54XC1", "name": "nt5c2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279053", "map_id": "DDB_G0279053", "name": "nt5c2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674782", "map_id": "none", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10673675", "map_id": "P20425", "name": "pyrK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287495", "map_id": "DDB_G0287495", "name": "pyrK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724032", "map_id": "none", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026761", "map_id": "CHEBI:138202", "name": "MCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10688148", "map_id": "none", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947496", "map_id": "CHEBI:58698", "name": "MPT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947561", "map_id": "CHEBI:36264", "name": "MoO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10688145", "map_id": "none", "name": "3xGPHN:3xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54KM0", "map_id": "Q54KM0", "name": "gphn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287261", "map_id": "DDB_G0287261", "name": "gphn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723969", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024879", "map_id": "CHEBI:140202", "name": "AT-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10696146", "map_id": "none", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142726", "map_id": "CHEBI:63984", "name": "EXC4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10671969", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680345", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680342", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q559K0", "map_id": "Q559K0", "name": "SLC19A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272544", "map_id": "DDB_G0272544", "name": "SLC19A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697786", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:61314", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10687079", "map_id": "none", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_880013", "map_id": "CHEBI:32797", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10687076", "map_id": "Q55GI5", "name": "l2hgdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0267656", "map_id": "DDB_G0267656", "name": "l2hgdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683622", "map_id": "none", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389664", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389680", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10683619", "map_id": "none", "name": "AGXT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54GT6", "map_id": "Q54GT6", "name": "agxt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289923", "map_id": "DDB_G0289923", "name": "agxt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673846", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_500742", "map_id": "CHEBI:246422", "name": "dUMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10673843", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BW5", "map_id": "Q54BW5", "name": "dut", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293374", "map_id": "DDB_G0293374", "name": "dut", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698355", "map_id": "none", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995348", "map_id": "CHEBI:24479", "name": "heme A", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10698352", "map_id": "O76740", "name": "coxA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0281549", "map_id": "DDB_G0281549", "name": "coxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712045", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10671408", "map_id": "P83401", "name": "ALDH7A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10679382", "map_id": "none", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189487", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10679379", "map_id": "none", "name": "2x(FECH:2Fe-2S cluster)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IA8", "map_id": "Q54IA8", "name": "hemH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288891", "map_id": "DDB_G0288891", "name": "hemH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391232", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10723088", "map_id": "none", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9012375", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10701265", "map_id": "Q01501", "name": "porA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0271848", "map_id": "DDB_G0271848", "name": "porA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725646", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10723945", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020602", "map_id": "CHEBI:132802", "name": "5(S)-Hp-18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10678931", "map_id": "none", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678928", "map_id": "none", "name": "AHCY:NAD+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P10819", "map_id": "P10819", "name": "sahA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267418", "map_id": "DDB_G0267418", "name": "sahA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698646", "map_id": "none", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698608", "map_id": "none", "name": "MTRR:MTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674028", "map_id": "none", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111369", "map_id": "CHEBI:147287", "name": "FGAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111370", "map_id": "CHEBI:137981", "name": "AIR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680269", "map_id": "none", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10680266", "map_id": "none", "name": "Homologues of SLC25A16", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q551X6", "map_id": "Q551X6", "name": "mcfV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276261", "map_id": "DDB_G0276261", "name": "mcfV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EV4", "map_id": "Q54EV4", "name": "mcfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291312", "map_id": "DDB_G0291312", "name": "mcfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DU1", "map_id": "Q54DU1", "name": "mcfP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292034", "map_id": "DDB_G0292034", "name": "mcfP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QI8", "map_id": "Q54QI8", "name": "mcfR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283811", "map_id": "DDB_G0283811", "name": "mcfR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MZ4", "map_id": "Q54MZ4", "name": "mcfB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285599", "map_id": "DDB_G0285599", "name": "mcfB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10719220", "map_id": "none", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10693757", "map_id": "none", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023948", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10722474", "map_id": "none", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955853", "map_id": "CHEBI:47013", "name": "D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10722471", "map_id": "Q54UQ4", "name": "rbsk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280893", "map_id": "DDB_G0280893", "name": "rbsk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724048", "map_id": "none", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2026977", "map_id": "CHEBI:28364", "name": "EPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9028283", "map_id": "CHEBI:72801", "name": "5-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10671678", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671675", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DB4", "map_id": "Q55DB4", "name": "tdo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269714", "map_id": "DDB_G0269714", "name": "tdo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682013", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76328", "map_id": "CHEBI:28794", "name": "COUM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76452", "map_id": "CHEBI:27510", "name": "HCOU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682010", "map_id": "none", "name": "Cytochrome P450 (CYP2A13 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10723991", "map_id": "none", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022679", "map_id": "CHEBI:138477", "name": "18(S)-RvE3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10702273", "map_id": "none", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423723", "map_id": "none", "name": "AFXBO,AFNBO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78586", "map_id": "CHEBI:78586", "name": "CHEBI:78586", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5423730", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78587", "map_id": "CHEBI:78587", "name": "CHEBI:78587", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78581", "map_id": "CHEBI:78581", "name": "CHEBI:78581", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679061", "map_id": "none", "name": "MGST2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10675822", "map_id": "none", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500822", "map_id": "none", "name": "dC, Thy-dRib, dU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_500823", "map_id": "none", "name": "dCMP, TMP, dUMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10675819", "map_id": "Q54YL2", "name": "dak", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10719226", "map_id": "none", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10721331", "map_id": "none", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_977314", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10721320", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10721323", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10721328", "map_id": "Q55DQ6", "name": "MCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0270558", "map_id": "DDB_G0270558", "name": "MCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682331", "map_id": "none", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_266056", "map_id": "CHEBI:15647", "name": "LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10711938", "map_id": "none", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10711922", "map_id": "none", "name": "DHs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VG0", "map_id": "Q54VG0", "name": "odhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280353", "map_id": "DDB_G0280353", "name": "odhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FN7", "map_id": "Q55FN7", "name": "bkdB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268020", "map_id": "DDB_G0268020", "name": "bkdB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M22", "map_id": "Q54M22", "name": "bkdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286335", "map_id": "DDB_G0286335", "name": "bkdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711930", "map_id": "none", "name": "lipoylated DHs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10711935", "map_id": "Q54KY1", "name": "LIPT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0287107", "map_id": "DDB_G0287107", "name": "LIPT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671117", "map_id": "none", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10725639", "map_id": "none", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9661418", "map_id": "CHEBI:16990", "name": "BIL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10703403", "map_id": "none", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662665", "map_id": "CHEBI:49108", "name": "Dopachrome", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10703400", "map_id": "none", "name": "DCT:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10696248", "map_id": "none", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2162213", "map_id": "CHEBI:30763", "name": "PHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162207", "map_id": "CHEBI:64136", "name": "DHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10696245", "map_id": "Q54U71", "name": "coq2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0281241", "map_id": "DDB_G0281241", "name": "coq2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725998", "map_id": "none", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725995", "map_id": "none", "name": "DHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LA0", "map_id": "Q54LA0", "name": "DHFR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714822", "map_id": "none", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10684864", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674036", "map_id": "none", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111354", "map_id": "CHEBI:147286", "name": "N-Formyl-GAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674033", "map_id": "Q54JC8", "name": "purL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288145", "map_id": "DDB_G0288145", "name": "purL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698347", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10698344", "map_id": "Q54JB3", "name": "cox10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0288169", "map_id": "DDB_G0288169", "name": "cox10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696168", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10696165", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10682321", "map_id": "none", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266013", "map_id": "CHEBI:16978", "name": "LTC4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10675770", "map_id": "none", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500201", "map_id": "none", "name": "dA, dG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500199", "map_id": "none", "name": "dAMP, dGMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684070", "map_id": "none", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684067", "map_id": "none", "name": "PLC beta1,2,3:G-alpha(q):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10723505", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10683783", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683481", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q8T8P3", "map_id": "Q8T8P3", "name": "abcD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679390", "map_id": "none", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189449", "map_id": "CHEBI:57845", "name": "HMBL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10679387", "map_id": "Q54NS4", "name": "hemD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285009", "map_id": "DDB_G0285009", "name": "hemD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699265", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699263", "map_id": "none", "name": "glycogen-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678959", "map_id": "none", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_174911", "map_id": "none", "name": "O-centre functional group substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:16580", "map_id": "CHEBI:16580", "name": "CHEBI:16580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_174914", "map_id": "none", "name": "O-glucuronide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:32649", "map_id": "CHEBI:32649", "name": "CHEBI:32649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_158604", "map_id": "CHEBI:132962", "name": "APAP-GlcA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:65137", "map_id": "CHEBI:65137", "name": "CHEBI:65137", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:176976", "map_id": "CHEBI:176976", "name": "CHEBI:176976", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:64681", "map_id": "CHEBI:64681", "name": "CHEBI:64681", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10678956", "map_id": "none", "name": "UGTs (O-GlcA forming)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10671668", "map_id": "none", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29586", "map_id": "CHEBI:29806", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671665", "map_id": "none", "name": "FAH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXQ1", "map_id": "Q1ZXQ1", "name": "fah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271094", "map_id": "DDB_G0271094", "name": "fah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721317", "map_id": "none", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932979", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10721306", "map_id": "Q54UF8", "name": "serinc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0281099", "map_id": "DDB_G0281099", "name": "serinc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714397", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806829", "map_id": "CHEBI:17826", "name": "MMAIII", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6800127", "map_id": "CHEBI:48765", "name": "DMAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10715501", "map_id": "none", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_6808468", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_2453691", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10715498", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "reaction_10711244", "map_id": "none", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6788813", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6788807", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10711241", "map_id": "Q54Y03", "name": "AK6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0278493", "map_id": "DDB_G0278493", "name": "AK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671068", "map_id": "none", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671065", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10720456", "map_id": "none", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720448", "map_id": "Q54YX3", "name": "TTPA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10691374", "map_id": "none", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691371", "map_id": "none", "name": "GCH1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94465", "map_id": "Q94465", "name": "gchA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288481", "map_id": "DDB_G0288481", "name": "gchA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724050", "map_id": "none", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9028240", "map_id": "CHEBI:140250", "name": "7-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10723943", "map_id": "none", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10670918", "map_id": "none", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29452", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670915", "map_id": "none", "name": "GALE:NAD+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q553X7", "map_id": "Q553X7", "name": "galE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275295", "map_id": "DDB_G0275295", "name": "galE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709876", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10709873", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10679064", "map_id": "none", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_176065", "map_id": "none", "name": "electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:27561", "map_id": "CHEBI:27561", "name": "CHEBI:27561", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176048", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:2505", "map_id": "CHEBI:2505", "name": "CHEBI:2505", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:35896", "map_id": "CHEBI:35896", "name": "CHEBI:35896", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709696", "map_id": "none", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10709693", "map_id": "none", "name": "ALDH3A2-1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10714952", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10714949", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55CV0", "map_id": "Q55CV0", "name": "APOA1BP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269890", "map_id": "DDB_G0269890", "name": "APOA1BP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688509", "map_id": "none", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_977323", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10688506", "map_id": "Q54GK8", "name": "MLYCD(40-493)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0290089", "map_id": "DDB_G0290089", "name": "MLYCD(40-493)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10693760", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10674382", "map_id": "none", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10688244", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680007", "map_id": "none", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680004", "map_id": "none", "name": "NADK:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D76", "map_id": "Q54D76", "name": "NADK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292442", "map_id": "DDB_G0292442", "name": "NADK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698644", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10698641", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10693548", "map_id": "none", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629741", "map_id": "CHEBI:62918", "name": "I(3,4,6)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10715863", "map_id": "none", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809289", "map_id": "CHEBI:74452", "name": "NMNH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10715860", "map_id": "Q55A74", "name": "NUDT12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0272048", "map_id": "DDB_G0272048", "name": "NUDT12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684933", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_428662", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10684930", "map_id": "none", "name": "Homologues of PPAP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10693569", "map_id": "none", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10720464", "map_id": "none", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10720461", "map_id": "Q554Z5", "name": "aslB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0274939", "map_id": "DDB_G0274939", "name": "aslB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684725", "map_id": "none", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10684722", "map_id": "none", "name": "SLC26A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55FK8", "map_id": "Q55FK8", "name": "SLC26A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286611", "map_id": "DDB_G0286611", "name": "SLC26A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G157", "map_id": "B0G157", "name": "SLC26A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686646", "map_id": "none", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10686643", "map_id": "none", "name": "GLUT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10675490", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10675487", "map_id": "none", "name": "Cytochrome P450 (CYP2A3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10674039", "map_id": "none", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680570", "map_id": "none", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680556", "map_id": "none", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680040", "map_id": "Q54CY5", "name": "folC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10693664", "map_id": "none", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10680533", "map_id": "none", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200709", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10680530", "map_id": "Q559K0", "name": "SLC19A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10680239", "map_id": "none", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680231", "map_id": "none", "name": "Homologues of FASN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680236", "map_id": "Q54MI2", "name": "AASDHPPT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285927", "map_id": "DDB_G0285927", "name": "AASDHPPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696179", "map_id": "none", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142738", "map_id": "CHEBI:63989", "name": "15R-HETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161609", "map_id": "none", "name": "15epi-LXA4/B4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:63991", "map_id": "CHEBI:63991", "name": "CHEBI:63991", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63990", "map_id": "CHEBI:63990", "name": "CHEBI:63990", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670982", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670979", "map_id": "none", "name": "PFK tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P90521", "map_id": "P90521", "name": "pfkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274111", "map_id": "DDB_G0274111", "name": "pfkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680043", "map_id": "none", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675644", "map_id": "none", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77332", "map_id": "CHEBI:27537", "name": "trans-Oct-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77330", "map_id": "CHEBI:28632", "name": "(S)-Hydroxyoctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10674311", "map_id": "none", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10674308", "map_id": "none", "name": "HMGCL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10682486", "map_id": "none", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682483", "map_id": "Q8T1E3", "name": "amd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275567", "map_id": "DDB_G0275567", "name": "amd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670870", "map_id": "none", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670867", "map_id": "none", "name": "8xUGP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YZ0", "map_id": "Q54YZ0", "name": "ugpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277879", "map_id": "DDB_G0277879", "name": "ugpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671223", "map_id": "none", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508261", "map_id": "none", "name": "BCAA-CoAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10671220", "map_id": "none", "name": "lipo-BCKDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10691385", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691382", "map_id": "none", "name": "p-PTPS hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXI0", "map_id": "Q1ZXI0", "name": "phospho-ptsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279095", "map_id": "DDB_G0279095", "name": "phospho-ptsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671441", "map_id": "none", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10671438", "map_id": "none", "name": "IDH3 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54B68", "map_id": "Q54B68", "name": "idhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293872", "map_id": "DDB_G0293872", "name": "idhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BI2", "map_id": "Q55BI2", "name": "idhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271344", "map_id": "DDB_G0271344", "name": "idhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702283", "map_id": "none", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5490236", "map_id": "none", "name": "AFXBO-NAC,AFNBO-NAC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78585", "map_id": "CHEBI:78585", "name": "CHEBI:78585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78580", "map_id": "CHEBI:78580", "name": "CHEBI:78580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5490231", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78578", "map_id": "CHEBI:78578", "name": "CHEBI:78578", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78583", "map_id": "CHEBI:78583", "name": "CHEBI:78583", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702280", "map_id": "none", "name": "ACY1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DP8", "map_id": "Q55DP8", "name": "acy1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270562", "map_id": "DDB_G0270562", "name": "acy1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10723959", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10683750", "map_id": "none", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390246", "map_id": "CHEBI:52974", "name": "tetracosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10723973", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10682096", "map_id": "none", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211939", "map_id": "CHEBI:8107", "name": "Phenytoin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211927", "map_id": "CHEBI:63804", "name": "HPHT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10682093", "map_id": "none", "name": "Cytochrome P450 (CYP2C18 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10717974", "map_id": "none", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853396", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10717971", "map_id": "none", "name": "MAN2B1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10698294", "map_id": "none", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698280", "map_id": "none", "name": "6x(PCCA:PCCB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698286", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679956", "map_id": "none", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679953", "map_id": "none", "name": "2xTPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GR8", "map_id": "Q55GR8", "name": "TPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267546", "map_id": "DDB_G0267546", "name": "TPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724025", "map_id": "none", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026400", "map_id": "CHEBI:91274", "name": "13(R)-HDPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026394", "map_id": "none", "name": "RvT1-4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137019", "map_id": "CHEBI:137019", "name": "CHEBI:137019", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137020", "map_id": "CHEBI:137020", "name": "CHEBI:137020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137018", "map_id": "CHEBI:137018", "name": "CHEBI:137018", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137011", "map_id": "CHEBI:137011", "name": "CHEBI:137011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683754", "map_id": "none", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10724044", "map_id": "none", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027324", "map_id": "none", "name": "14(R),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137368", "map_id": "CHEBI:137368", "name": "CHEBI:137368", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137361", "map_id": "CHEBI:137361", "name": "CHEBI:137361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10671591", "map_id": "none", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10671588", "map_id": "none", "name": "QDPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86A17", "map_id": "Q86A17", "name": "qdpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272684", "map_id": "DDB_G0272684", "name": "qdpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682470", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10699535", "map_id": "none", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699495", "map_id": "none", "name": "HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UC1", "map_id": "Q54UC1", "name": "phospho-p-S303-HSF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281165", "map_id": "DDB_G0281165", "name": "phospho-p-S303-HSF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699531", "map_id": "none", "name": "HSBP1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q556J3", "map_id": "Q556J3", "name": "HSBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272620", "map_id": "DDB_G0272620", "name": "HSBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699533", "map_id": "none", "name": "HSBP1:HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10685442", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685439", "map_id": "Q54T06", "name": "SLC30A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0282067", "map_id": "DDB_G0282067", "name": "SLC30A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685527", "map_id": "none", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674709", "map_id": "none", "name": "YWHAQ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684045", "map_id": "none", "name": "Homologues of RAF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10685525", "map_id": "none", "name": "14-3-3-zeta:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685468", "map_id": "none", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683907", "map_id": "none", "name": "PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674822", "map_id": "none", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10674810", "map_id": "none", "name": "phospho(T286)-Cyclin D1:Cdk4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674820", "map_id": "none", "name": "phospho(T286)-Cyclin D1:Cdk4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674828", "map_id": "none", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674826", "map_id": "none", "name": "multi-ubiquitinated phospho-(T286) Cyclin D1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10674824", "map_id": "none", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10674806", "map_id": "none", "name": "Homologues of p-T286-CCND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674816", "map_id": "none", "name": "Homologues of p-T286-CCND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10720815", "map_id": "none", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10720749", "map_id": "none", "name": "GGC-RAB21:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM7", "map_id": "Q55FM7", "name": "GDI2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268034", "map_id": "DDB_G0268034", "name": "GDI2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10720472", "map_id": "none", "name": "GDIs,CHMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720753", "map_id": "none", "name": "GGC-RAB21:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10720812", "map_id": "none", "name": "RAB21 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PZ6", "map_id": "Q54PZ6", "name": "ANKRD27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284213", "map_id": "DDB_G0284213", "name": "ANKRD27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721139", "map_id": "none", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10721116", "map_id": "none", "name": "RAB32,RAB38:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721124", "map_id": "none", "name": "RAB32,RAB38:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10721136", "map_id": "none", "name": "HPS1:HPS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FG6", "map_id": "Q55FG6", "name": "HPS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268126", "map_id": "DDB_G0268126", "name": "HPS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M79", "map_id": "Q54M79", "name": "HPS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286137", "map_id": "DDB_G0286137", "name": "HPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720997", "map_id": "none", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10720948", "map_id": "none", "name": "GGC-RAB7:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720978", "map_id": "none", "name": "GGC-RAB7:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10720994", "map_id": "none", "name": "MON1:CCZ1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IQ5", "map_id": "Q54IQ5", "name": "CCZ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288589", "map_id": "DDB_G0288589", "name": "CCZ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TG0", "map_id": "Q54TG0", "name": "MON1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281773", "map_id": "DDB_G0281773", "name": "MON1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720737", "map_id": "none", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720721", "map_id": "none", "name": "GGC-RAB14:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720725", "map_id": "none", "name": "GGC-RAB14:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10720734", "map_id": "none", "name": "DENND6A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VA9", "map_id": "Q54VA9", "name": "DENND6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280481", "map_id": "DDB_G0280481", "name": "DENND6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721062", "map_id": "none", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane" }, { "id": "species_10721005", "map_id": "none", "name": "GGC-RAB1:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721035", "map_id": "none", "name": "GGC-RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "species_10721059", "map_id": "none", "name": "TRAPPCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CV2", "map_id": "Q54CV2", "name": "TRAPPC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292682", "map_id": "DDB_G0292682", "name": "TRAPPC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KR2", "map_id": "Q54KR2", "name": "TRAPPC11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287157", "map_id": "DDB_G0287157", "name": "TRAPPC11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U24", "map_id": "Q54U24", "name": "TRAPPC12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281351", "map_id": "DDB_G0281351", "name": "TRAPPC12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EX6", "map_id": "Q55EX6", "name": "TRAPPC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269062", "map_id": "DDB_G0269062", "name": "TRAPPC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720645", "map_id": "none", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10720638", "map_id": "none", "name": "GGC-RAB6:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720642", "map_id": "none", "name": "GGC-RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10720634", "map_id": "none", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10720551", "map_id": "none", "name": "GGC-RAB9:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720603", "map_id": "none", "name": "GGC-RAB9:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10720631", "map_id": "none", "name": "RAB9 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DD7", "map_id": "Q55DD7", "name": "DENND2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270918", "map_id": "DDB_G0270918", "name": "DENND2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JA6", "map_id": "Q54JA6", "name": "DENND2C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288237", "map_id": "DDB_G0288237", "name": "DENND2C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10720942", "map_id": "none", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10720880", "map_id": "none", "name": "GGC-RAB31:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10720884", "map_id": "none", "name": "GGC-RAB31:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10720939", "map_id": "none", "name": "RAB31 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HF9", "map_id": "Q54HF9", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291115", "map_id": "DDB_G0291115", "name": "RIN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W41", "map_id": "Q54W41", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F48", "map_id": "Q54F48", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VS5", "map_id": "Q54VS5", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AA6", "map_id": "Q55AA6", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NU1", "map_id": "Q54NU1", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AI4", "map_id": "Q55AI4", "name": "RIN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721156", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10721143", "map_id": "none", "name": "GGC-RAB18:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721147", "map_id": "none", "name": "GGC-RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10721153", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722918", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10722910", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54QH7", "map_id": "Q54QH7", "name": "NDUFB8(1-28)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283889", "map_id": "DDB_G0283889", "name": "NDUFB8(1-28)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BQ4", "map_id": "Q55BQ4", "name": "Q55BQ4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270806", "map_id": "DDB_G0270806", "name": "Q55BQ4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CS9", "map_id": "Q55CS9", "name": "atp5f1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269916", "map_id": "DDB_G0269916", "name": "atp5f1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U71", "map_id": "Q54U71", "name": "coq2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q37315", "map_id": "Q37315", "name": "atp9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294016", "map_id": "DDB_G0294016", "name": "atp9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722915", "map_id": "Q8MP58", "name": "PITRM1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0271506", "map_id": "DDB_G0271506", "name": "PITRM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679142", "map_id": "none", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679123", "map_id": "Q54HR6", "name": "gins1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289271", "map_id": "DDB_G0289271", "name": "gins1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679128", "map_id": "Q54BL9", "name": "gins2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293564", "map_id": "DDB_G0293564", "name": "gins2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679133", "map_id": "Q54EH6", "name": "gins3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291506", "map_id": "DDB_G0291506", "name": "gins3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679138", "map_id": "Q55EA2", "name": "gins4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269324", "map_id": "DDB_G0269324", "name": "gins4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10679140", "map_id": "none", "name": "GINS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55EA2", "map_id": "Q55EA2", "name": "gins4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BL9", "map_id": "Q54BL9", "name": "gins2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HR6", "map_id": "Q54HR6", "name": "gins1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EH6", "map_id": "Q54EH6", "name": "gins3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670519", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669631", "map_id": "none", "name": "MCM2-7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CP4", "map_id": "Q54CP4", "name": "mcm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292958", "map_id": "DDB_G0292958", "name": "mcm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VI9", "map_id": "Q54VI9", "name": "MCM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280309", "map_id": "DDB_G0280309", "name": "MCM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LI2", "map_id": "Q54LI2", "name": "MCM2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286623", "map_id": "DDB_G0286623", "name": "MCM2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B14", "map_id": "Q86B14", "name": "mcm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272760", "map_id": "DDB_G0272760", "name": "mcm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IF1", "map_id": "Q86IF1", "name": "MCM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275623", "map_id": "DDB_G0275623", "name": "MCM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RU0", "map_id": "Q54RU0", "name": "MCM7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282933", "map_id": "DDB_G0282933", "name": "MCM7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669627", "map_id": "Q54CP4", "name": "mcm5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669598", "map_id": "Q54LI2", "name": "MCM2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669622", "map_id": "Q54VI9", "name": "MCM3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669615", "map_id": "none", "name": "MCM4:MCM6:MCM7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10726207", "map_id": "none", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669617", "map_id": "none", "name": "MCM2:MCM4:MCM6:MCM7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669566", "map_id": "none", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669561", "map_id": "none", "name": "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RD4", "map_id": "Q54RD4", "name": "pole", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283189", "map_id": "DDB_G0283189", "name": "pole", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y85", "map_id": "Q54Y85", "name": "pole2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278367", "map_id": "DDB_G0278367", "name": "pole2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWN0", "map_id": "Q7KWN0", "name": "POLE4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272740", "map_id": "DDB_G0272740", "name": "POLE4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JQ9", "map_id": "Q75JQ9", "name": "pole3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272222", "map_id": "DDB_G0272222", "name": "pole3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669563", "map_id": "none", "name": "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10669557", "map_id": "none", "name": "DNA polymerase epsilon", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670517", "map_id": "none", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670400", "map_id": "none", "name": "ubiquitinated Cdc6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q552L8", "map_id": "Q552L8", "name": "CDC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275983", "map_id": "DDB_G0275983", "name": "CDC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726203", "map_id": "none", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669629", "map_id": "none", "name": "MCM3:MCM5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669568", "map_id": "none", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669559", "map_id": "none", "name": "DNA polymerase epsilon:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10669535", "map_id": "none", "name": "DNA polymerase alpha:primase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669647", "map_id": "none", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669573", "map_id": "Q55GA4", "name": "cdc45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0267748", "map_id": "DDB_G0267748", "name": "cdc45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669643", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54DK3", "map_id": "Q54DK3", "name": "cdc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292152", "map_id": "DDB_G0292152", "name": "cdc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RN8", "map_id": "Q54RN8", "name": "MCM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283009", "map_id": "DDB_G0283009", "name": "MCM8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10669645", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex:CDC45", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GA4", "map_id": "Q55GA4", "name": "cdc45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670368", "map_id": "none", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68419", "map_id": "none", "name": "origin of replication", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10670392", "map_id": "none", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669499", "map_id": "Q552L8", "name": "CDC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670371", "map_id": "Q552L8", "name": "phospho-p-CDC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670389", "map_id": "none", "name": "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10726144", "map_id": "none", "name": "MCM8 binds CDC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669506", "map_id": "Q54RN8", "name": "MCM8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669508", "map_id": "none", "name": "CDC6:MCM8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669949", "map_id": "none", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669659", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669920", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669946", "map_id": "none", "name": "SCF (SKP2) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10669510", "map_id": "none", "name": "CDC6 association with ORC(1-6) at replication origins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669501", "map_id": "none", "name": "ORC(1-6):CDC6:origin of replication", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670515", "map_id": "none", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670394", "map_id": "Q552L8", "name": "phospho-p-CDC6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10670359", "map_id": "none", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10669951", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10726205", "map_id": "none", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669603", "map_id": "Q86IF1", "name": "MCM4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669613", "map_id": "Q54RU0", "name": "MCM7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10669608", "map_id": "Q86B14", "name": "mcm6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10669953", "map_id": "none", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10670364", "map_id": "none", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29604", "map_id": "CHEBI:61404", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10726146", "map_id": "none", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10669687", "map_id": "none", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10669653", "map_id": "none", "name": "pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10669663", "map_id": "none", "name": "pre-replicative complex (Orc1-minus)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670396", "map_id": "none", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10682559", "map_id": "none", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10682537", "map_id": "none", "name": "Homologues of STK24(1-313)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QI2", "map_id": "Q54QI2", "name": "STK24(1-313)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293184", "map_id": "DDB_G0293184", "name": "STK24(1-313)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61122", "map_id": "O61122", "name": "svkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286359", "map_id": "DDB_G0286359", "name": "svkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DC8", "map_id": "Q54DC8", "name": "STK24(1-313)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C77", "map_id": "Q54C77", "name": "STK24(1-313)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682557", "map_id": "none", "name": "Homologues of STK24(1-313)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10682346", "map_id": "none", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29428", "map_id": "none", "name": "DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10682344", "map_id": "none", "name": "HMGB1/HMGB2- bound chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10682565", "map_id": "none", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682561", "map_id": "Q94464", "name": "dymA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10682563", "map_id": "Q94464", "name": "dymA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10682513", "map_id": "Q54K74", "name": "BCAP31(2-164)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0287543", "map_id": "DDB_G0287543", "name": "BCAP31(2-164)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697851", "map_id": "none", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10697839", "map_id": "none", "name": "CK2 Phosphorylated Condensin I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WY1", "map_id": "Q54WY1", "name": "NCAPG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279329", "map_id": "DDB_G0279329", "name": "NCAPG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B17", "map_id": "Q54B17", "name": "NCAPD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293984", "map_id": "DDB_G0293984", "name": "NCAPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DR4", "map_id": "Q54DR4", "name": "NCAPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292066", "map_id": "DDB_G0292066", "name": "NCAPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697849", "map_id": "none", "name": "Condensin I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2529006", "map_id": "none", "name": "Unknown Phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10697883", "map_id": "none", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10702356", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10702353", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10726153", "map_id": "none", "name": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9750012", "map_id": "CHEBI:58044", "name": "2,5-DHBA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9749985", "map_id": "CHEBI:90176", "name": "2,5-DHB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10726183", "map_id": "none", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753466", "map_id": "CHEBI:173517", "name": "NAPQI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10726180", "map_id": "none", "name": "GSTM1,P1,T1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10726191", "map_id": "none", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753629", "map_id": "none", "name": "APAP-Cys,APAP-Mer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:133438", "map_id": "CHEBI:133438", "name": "CHEBI:133438", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9753653", "map_id": "CHEBI:133067", "name": "APAP-Cys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9753624", "map_id": "none", "name": "APAP-Cys,APAP-Mer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:133066", "map_id": "CHEBI:133066", "name": "CHEBI:133066", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:133435", "map_id": "CHEBI:133435", "name": "CHEBI:133435", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10726188", "map_id": "none", "name": "ABCC1,4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10726193", "map_id": "none", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_9677362", "map_id": "LigandDisplayForward?ligandId=5239", "name": "APAP", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9753674", "map_id": "pubchem.compound:3767", "name": "isoniazid", "type": "catalyst", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10726151", "map_id": "none", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9749795", "map_id": "CHEBI:13719", "name": "ASA- (hepatocyte)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749588", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749790", "map_id": "CHEBI:30762", "name": "ST (hepatocyte)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10726156", "map_id": "none", "name": "UGT1A6 glucuronates ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9749997", "map_id": "CHEBI:176960", "name": "SAAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677028", "map_id": "none", "name": "Homologues of UGT1A6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10726178", "map_id": "none", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753559", "map_id": "none", "name": "APAP-GlcA, APAP-SO3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:32635", "map_id": "CHEBI:32635", "name": "CHEBI:32635", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9753562", "map_id": "none", "name": "APAP-GlcA, APAP-SO3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:32636", "map_id": "CHEBI:32636", "name": "CHEBI:32636", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10726175", "map_id": "none", "name": "ABCC2, ABCG2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10726168", "map_id": "none", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9750692", "map_id": "none", "name": "salicylate metabolites", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:9008", "map_id": "CHEBI:9008", "name": "CHEBI:9008", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:88742", "map_id": "CHEBI:88742", "name": "CHEBI:88742", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9750011", "map_id": "CHEBI:36654", "name": "2,3-DHBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9750678", "map_id": "none", "name": "salicylate metabolites", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10726165", "map_id": "none", "name": "ABCC2, ABCC3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54NL1", "map_id": "Q54NL1", "name": "abcC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726158", "map_id": "none", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10726160", "map_id": "none", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9750014", "map_id": "CHEBI:58044", "name": "2,5-DHBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10726149", "map_id": "none", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_9749582", "map_id": "CHEBI:13719", "name": "ASA- (GI cell)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_9749593", "map_id": "CHEBI:30762", "name": "ST (GI cell)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10709871", "map_id": "none", "name": "Homologues of CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10726197", "map_id": "none", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753926", "map_id": "CHEBI:78236", "name": "NAC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9717939", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10696232", "map_id": "none", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161185", "map_id": "LigandDisplayForward?ligandId=11152", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2162081", "map_id": "CHEBI:64192", "name": "abacavir 5'-carboxylic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10671976", "map_id": "none", "name": "ADH1A:2Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677043", "map_id": "none", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158601", "map_id": "CHEBI:58052", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677040", "map_id": "none", "name": "UGTs (APAP substrate)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10726186", "map_id": "none", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10696229", "map_id": "none", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161514", "map_id": "pubchem.compound:135403630", "name": "carbovir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161176", "map_id": "pubchem.compound:135565291", "name": "carbovir monophosphate", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10726195", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9753680", "map_id": "CHEBI:180460", "name": "APAP-CysGly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10673891", "map_id": "none", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10673887", "map_id": "Q54HB0", "name": "RRN3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289587", "map_id": "DDB_G0289587", "name": "RRN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673882", "map_id": "none", "name": "RNA Polymerase I Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54YF5", "map_id": "Q54YF5", "name": "rpa12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278263", "map_id": "DDB_G0278263", "name": "rpa12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FA4", "map_id": "Q55FA4", "name": "rpa43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268198", "map_id": "DDB_G0268198", "name": "rpa43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FE8", "map_id": "Q54FE8", "name": "polr1e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290909", "map_id": "DDB_G0290909", "name": "polr1e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H36", "map_id": "Q86H36", "name": "polr1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275759", "map_id": "DDB_G0275759", "name": "polr1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BM1", "map_id": "Q54BM1", "name": "polr1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293560", "map_id": "DDB_G0293560", "name": "polr1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SN4", "map_id": "Q54SN4", "name": "polr1c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282339", "map_id": "DDB_G0282339", "name": "polr1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10673889", "map_id": "none", "name": "Active RNA Polymerase I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HB0", "map_id": "Q54HB0", "name": "RRN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674680", "map_id": "none", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_350", "compartment_display": "nucleolus" }, { "id": "species_74985", "map_id": "none", "name": "elongating pre-rRNA transcript", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10673976", "map_id": "none", "name": "RNA Polymerase I promoter escape complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q554V6", "map_id": "Q554V6", "name": "Ac-TAF1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274953", "map_id": "DDB_G0274953", "name": "Ac-TAF1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674678", "map_id": "none", "name": "Chromatin (H3K9me2):CBX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RQ4", "map_id": "Q54RQ4", "name": "CBX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282987", "map_id": "DDB_G0282987", "name": "CBX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C69", "map_id": "Q55C69", "name": "hcpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270198", "map_id": "DDB_G0270198", "name": "hcpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RN0", "map_id": "Q54RN0", "name": "CBX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283023", "map_id": "DDB_G0283023", "name": "CBX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10673978", "map_id": "none", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10673972", "map_id": "none", "name": "RNA Polymerase I Transcription Initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10683664", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683658", "map_id": "none", "name": "PAK1,2,3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10683660", "map_id": "none", "name": "PAK1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10683662", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10705971", "map_id": "none", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10705850", "map_id": "none", "name": "Homologues of ub-MAPK6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10705961", "map_id": "none", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10705931", "map_id": "none", "name": "MAPK4,6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10705959", "map_id": "none", "name": "MAPK4,6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709756", "map_id": "none", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705955", "map_id": "none", "name": "Homologues of MAPK6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670747", "map_id": "none", "name": "Homologues of CCND3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709754", "map_id": "none", "name": "MAPK6:CCND3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705903", "map_id": "none", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10705864", "map_id": "none", "name": "MAPK6,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10705900", "map_id": "none", "name": "p-S MAPK6,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10705968", "map_id": "none", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705966", "map_id": "Q54EV7", "name": "xpo1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291306", "map_id": "DDB_G0291306", "name": "xpo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685265", "map_id": "none", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685262", "map_id": "none", "name": "p-S256-AQP2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685272", "map_id": "none", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685269", "map_id": "none", "name": "AQP4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685247", "map_id": "none", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10685249", "map_id": "none", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10674798", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674686", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10724052", "map_id": "none", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10705346", "map_id": "none", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705342", "map_id": "Q54MH0", "name": "phospho-fhkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10705344", "map_id": "none", "name": "p-T68-CHEK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MH0", "map_id": "Q54MH0", "name": "phospho-fhkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10705349", "map_id": "none", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674688", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10702591", "map_id": "none", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10702588", "map_id": "none", "name": "p21 RAS:GTP:RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702566", "map_id": "none", "name": "p21 RAS:GTP:p-S338-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10698157", "map_id": "none", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10695461", "map_id": "none", "name": "Calcineurin (CaN)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55G87", "map_id": "Q55G87", "name": "cnbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267446", "map_id": "DDB_G0267446", "name": "cnbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YSW8", "map_id": "Q7YSW8", "name": "canA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276883", "map_id": "DDB_G0276883", "name": "canA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698131", "map_id": "none", "name": "Calcineurin:Calmodulin (CaN:CaM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10698155", "map_id": "none", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698135", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698153", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702593", "map_id": "none", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10702481", "map_id": "none", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702478", "map_id": "none", "name": "acetylated microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701954", "map_id": "Q54X15", "name": "hdaD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10706065", "map_id": "none", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_5688282", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10706055", "map_id": "Q869N1", "name": "cytC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5688340", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5688281", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10706062", "map_id": "none", "name": "SIRT5:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q55DB0", "map_id": "Q55DB0", "name": "sir2E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270928", "map_id": "DDB_G0270928", "name": "sir2E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722767", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722762", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10722748", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10676269", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10676262", "map_id": "Q86H13", "name": "Pde4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0289121", "map_id": "DDB_G0289121", "name": "Pde4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678297", "map_id": "none", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678285", "map_id": "none", "name": "G alpha-olf:GTP:Adenylate cyclase (active) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10678304", "map_id": "none", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678299", "map_id": "none", "name": "G alpha-olf:GDP:Adenylate cyclase (active) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722750", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722746", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682978", "map_id": "none", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10682971", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682975", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10678288", "map_id": "none", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10678301", "map_id": "none", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10677642", "map_id": "none", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10676139", "map_id": "none", "name": "G-protein alpha (q/11/14/15)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722764", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678270", "map_id": "none", "name": "G alpha (i): GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724973", "map_id": "none", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679149", "map_id": "Q86H13", "name": "phospho-Pde4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10697954", "map_id": "none", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10697951", "map_id": "none", "name": "Slo3 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86I16", "map_id": "Q86I16", "name": "KCNU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275169", "map_id": "DDB_G0275169", "name": "KCNU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SN1", "map_id": "Q54SN1", "name": "potA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282291", "map_id": "DDB_G0282291", "name": "potA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CU6", "map_id": "Q55CU6", "name": "KCNU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676383", "map_id": "none", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676338", "map_id": "Q75JA4", "name": "CTDP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672161", "map_id": "none", "name": "capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676376", "map_id": "none", "name": "RNA Pol II (hypophosphorylated):capped pre-mRNA complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676458", "map_id": "none", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676454", "map_id": "none", "name": "Elongation complex prior to separation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q555G9", "map_id": "Q555G9", "name": "cdc73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274885", "map_id": "DDB_G0274885", "name": "cdc73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A81", "map_id": "Q86A81", "name": "IWS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274327", "map_id": "DDB_G0274327", "name": "IWS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y92", "map_id": "Q54Y92", "name": "DG1071", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277841", "map_id": "DDB_G0277841", "name": "DG1071", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AD4", "map_id": "Q55AD4", "name": "MLLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271948", "map_id": "DDB_G0271948", "name": "MLLT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP1", "map_id": "Q54LP1", "name": "RTF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286523", "map_id": "DDB_G0286523", "name": "RTF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E33", "map_id": "Q55E33", "name": "PAF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269412", "map_id": "DDB_G0269412", "name": "PAF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A48", "map_id": "Q55A48", "name": "SUPT6H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272354", "map_id": "DDB_G0272354", "name": "SUPT6H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB8", "map_id": "Q54MB8", "name": "leo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286051", "map_id": "DDB_G0286051", "name": "leo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676456", "map_id": "none", "name": "Elongation complex with separated and uncleaved transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676444", "map_id": "none", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676440", "map_id": "none", "name": "Elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676442", "map_id": "none", "name": "Processive elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676466", "map_id": "none", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676333", "map_id": "none", "name": "DSIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676378", "map_id": "none", "name": "RNA Pol II (hypophosphorylated) complex bound to DSIF protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676472", "map_id": "none", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10697522", "map_id": "none", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473617", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674488", "map_id": "Q54YX3", "name": "RLBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10697520", "map_id": "none", "name": "RLBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5623649", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10697518", "map_id": "none", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674490", "map_id": "none", "name": "RLBP1:11cROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_30927", "map_id": "CHEBI:16302", "name": "11cROL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10697513", "map_id": "none", "name": "RLBP1:11cRPALM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16254", "map_id": "CHEBI:16254", "name": "CHEBI:16254", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10676906", "map_id": "none", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676900", "map_id": "Q54M64", "name": "nudc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286159", "map_id": "DDB_G0286159", "name": "phospho-nudc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676904", "map_id": "Q54M64", "name": "phospho-nudc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676892", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10697578", "map_id": "none", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10697563", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10697575", "map_id": "none", "name": "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10678756", "map_id": "Q86HN7", "name": "PLK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675117", "map_id": "none", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675113", "map_id": "none", "name": "RNA Polymerase III Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86JI9", "map_id": "Q86JI9", "name": "rpc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271514", "map_id": "DDB_G0271514", "name": "rpc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AQ5", "map_id": "Q86AQ5", "name": "polr3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277199", "map_id": "DDB_G0277199", "name": "polr3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IM0", "map_id": "Q54IM0", "name": "POLR3GL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288665", "map_id": "DDB_G0288665", "name": "POLR3GL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557J3", "map_id": "Q557J3", "name": "polr3h-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273425", "map_id": "DDB_G0273425", "name": "polr3h-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JM3", "map_id": "Q86JM3", "name": "polr3f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272022", "map_id": "DDB_G0272022", "name": "polr3f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FJ5", "map_id": "Q55FJ5", "name": "polr3c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268080", "map_id": "DDB_G0268080", "name": "polr3c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T1V7", "map_id": "Q8T1V7", "name": "polr3d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277671", "map_id": "DDB_G0277671", "name": "polr3d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP2", "map_id": "Q54LP2", "name": "rpc9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286521", "map_id": "DDB_G0286521", "name": "rpc9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IZ9", "map_id": "Q54IZ9", "name": "polr3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288449", "map_id": "DDB_G0288449", "name": "polr3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K02", "map_id": "Q54K02", "name": "rpc11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287707", "map_id": "DDB_G0287707", "name": "rpc11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675051", "map_id": "none", "name": "TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54GS8", "map_id": "Q54GS8", "name": "gtf3c5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289935", "map_id": "DDB_G0289935", "name": "gtf3c5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WL4", "map_id": "Q54WL4", "name": "GTF3C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279565", "map_id": "DDB_G0279565", "name": "GTF3C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FU1", "map_id": "Q54FU1", "name": "GTF3C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290591", "map_id": "DDB_G0290591", "name": "GTF3C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YB5", "map_id": "Q54YB5", "name": "TFIIIC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278321", "map_id": "DDB_G0278321", "name": "TFIIIC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U85", "map_id": "Q54U85", "name": "TFIIIB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281215", "map_id": "DDB_G0281215", "name": "TFIIIB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T1F9", "map_id": "Q8T1F9", "name": "GTF3C6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275127", "map_id": "DDB_G0275127", "name": "GTF3C6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R53", "map_id": "Q54R53", "name": "TFIIIB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283405", "map_id": "DDB_G0283405", "name": "TFIIIB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675115", "map_id": "none", "name": "RNA polymerase III:TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10725407", "map_id": "none", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657567", "map_id": "none", "name": "dual mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "pubchem.compound:16719221", "map_id": "pubchem.compound:16719221", "name": "pubchem.compound:16719221", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9909", "map_id": "LigandDisplayForward?ligandId=9909", "name": "LigandDisplayForward?ligandId=9909", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6495", "map_id": "LigandDisplayForward?ligandId=6495", "name": "LigandDisplayForward?ligandId=6495", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704197", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q75JK0", "map_id": "Q75JK0", "name": "phospho-zakA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276025", "map_id": "DDB_G0276025", "name": "phospho-zakA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DF2", "map_id": "Q54DF2", "name": "mrkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292304", "map_id": "DDB_G0292304", "name": "mrkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VU4", "map_id": "Q54VU4", "name": "MARK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280133", "map_id": "DDB_G0280133", "name": "MARK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552C6", "map_id": "Q552C6", "name": "phospho-zak2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276187", "map_id": "DDB_G0276187", "name": "phospho-zak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FV4", "map_id": "Q55FV4", "name": "fnkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267934", "map_id": "DDB_G0267934", "name": "fnkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18160", "map_id": "P18160", "name": "phospho-splA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283385", "map_id": "DDB_G0283385", "name": "phospho-splA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704199", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10704211", "map_id": "none", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704188", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10704209", "map_id": "none", "name": "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=8943", "map_id": "LigandDisplayForward?ligandId=8943", "name": "LigandDisplayForward?ligandId=8943", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10387", "map_id": "LigandDisplayForward?ligandId=10387", "name": "LigandDisplayForward?ligandId=10387", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9977", "map_id": "LigandDisplayForward?ligandId=9977", "name": "LigandDisplayForward?ligandId=9977", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725409", "map_id": "none", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657570", "map_id": "none", "name": "dual mechanism MAPK inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=8056", "map_id": "LigandDisplayForward?ligandId=8056", "name": "LigandDisplayForward?ligandId=8056", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9974", "map_id": "LigandDisplayForward?ligandId=9974", "name": "LigandDisplayForward?ligandId=9974", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704201", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725415", "map_id": "none", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657577", "map_id": "none", "name": "single mechanism MAPK inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=9210", "map_id": "LigandDisplayForward?ligandId=9210", "name": "LigandDisplayForward?ligandId=9210", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9375", "map_id": "LigandDisplayForward?ligandId=9375", "name": "LigandDisplayForward?ligandId=9375", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9229", "map_id": "LigandDisplayForward?ligandId=9229", "name": "LigandDisplayForward?ligandId=9229", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704192", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10725413", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725411", "map_id": "none", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657574", "map_id": "none", "name": "single mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7626", "map_id": "LigandDisplayForward?ligandId=7626", "name": "LigandDisplayForward?ligandId=7626", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7872", "map_id": "LigandDisplayForward?ligandId=7872", "name": "LigandDisplayForward?ligandId=7872", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7935", "map_id": "LigandDisplayForward?ligandId=7935", "name": "LigandDisplayForward?ligandId=7935", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5665", "map_id": "LigandDisplayForward?ligandId=5665", "name": "LigandDisplayForward?ligandId=5665", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7942", "map_id": "LigandDisplayForward?ligandId=7942", "name": "LigandDisplayForward?ligandId=7942", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5676", "map_id": "LigandDisplayForward?ligandId=5676", "name": "LigandDisplayForward?ligandId=5676", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7921", "map_id": "LigandDisplayForward?ligandId=7921", "name": "LigandDisplayForward?ligandId=7921", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704195", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10704203", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10704251", "map_id": "none", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10704247", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54H44", "map_id": "Q54H44", "name": "morg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289711", "map_id": "DDB_G0289711", "name": "morg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704249", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10700856", "map_id": "none", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696623", "map_id": "none", "name": "H3K4me2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698653", "map_id": "none", "name": "MeK5-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700853", "map_id": "none", "name": "KDM5A-D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55ER4", "map_id": "Q55ER4", "name": "KDM5D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268778", "map_id": "DDB_G0268778", "name": "KDM5D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699170", "map_id": "none", "name": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698655", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113560", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2485002", "map_id": "CHEBI:57287", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699149", "map_id": "none", "name": "AcK15-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10699167", "map_id": "none", "name": "KAT6:ING5:MEAF6:BRPF1,(2,3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10701877", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696628", "map_id": "none", "name": "H3K4me3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701874", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55AQ4", "map_id": "Q55AQ4", "name": "ASH2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271754", "map_id": "DDB_G0271754", "name": "ASH2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IV4", "map_id": "Q54IV4", "name": "SMYD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288495", "map_id": "DDB_G0288495", "name": "SMYD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HS3", "map_id": "Q54HS3", "name": "set1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289257", "map_id": "DDB_G0289257", "name": "set1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701399", "map_id": "none", "name": "Me2aR3-histone H3, MeR3-histone H3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703003", "map_id": "none", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702990", "map_id": "none", "name": "MeK80-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10702995", "map_id": "none", "name": "Me2K80-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10703000", "map_id": "Q55AX2", "name": "dotA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271626", "map_id": "DDB_G0271626", "name": "dotA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701096", "map_id": "none", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701093", "map_id": "none", "name": "SETD3, SETD7, WHSC1L1, Core MLL complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55FP6", "map_id": "Q55FP6", "name": "SETD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287857", "map_id": "DDB_G0287857", "name": "SETD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JW6", "map_id": "Q54JW6", "name": "SETD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A13", "map_id": "Q86A13", "name": "SETD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FF7", "map_id": "Q55FF7", "name": "WHSC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268132", "map_id": "DDB_G0268132", "name": "WHSC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J80", "map_id": "Q54J80", "name": "SETD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288227", "map_id": "DDB_G0288227", "name": "SETD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703010", "map_id": "none", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703008", "map_id": "none", "name": "Me3K80-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700971", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700828", "map_id": "none", "name": "MeK37-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700968", "map_id": "none", "name": "WHSC1, NSD1, SMYD2, ASH1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ZX8", "map_id": "Q54ZX8", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294629", "map_id": "DDB_G0294629", "name": "SMYD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D67", "map_id": "Q54D67", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX4", "map_id": "Q55FX4", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557F7", "map_id": "Q557F7", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XN6", "map_id": "Q54XN6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GG3", "map_id": "Q54GG3", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL6", "map_id": "Q54DL6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R14", "map_id": "Q54R14", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G064", "map_id": "C7G064", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DC8", "map_id": "Q55DC8", "name": "bopA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270830", "map_id": "DDB_G0270830", "name": "bopA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G196", "map_id": "B0G196", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557F6", "map_id": "Q557F6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701276", "map_id": "none", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698791", "map_id": "none", "name": "MeR9-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698692", "map_id": "none", "name": "CCND1:CDK4:PRMT5:pT5-WDR77", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KI3", "map_id": "Q54KI3", "name": "prmt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287327", "map_id": "DDB_G0287327", "name": "prmt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701274", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54NM0", "map_id": "Q54NM0", "name": "SMARCA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WV6", "map_id": "Q54WV6", "name": "SMARCB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279373", "map_id": "DDB_G0279373", "name": "SMARCB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Z0", "map_id": "Q556Z0", "name": "snf12-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273203", "map_id": "DDB_G0273203", "name": "snf12-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UQ7", "map_id": "Q54UQ7", "name": "ACTL6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280887", "map_id": "DDB_G0280887", "name": "ACTL6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550R6", "map_id": "Q550R6", "name": "SMARCC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277033", "map_id": "DDB_G0277033", "name": "SMARCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703386", "map_id": "none", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701268", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10703384", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698675", "map_id": "Q54EF2", "name": "prmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10703018", "map_id": "none", "name": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700861", "map_id": "none", "name": "Me2K28-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10703016", "map_id": "none", "name": "Me3K28-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10702954", "map_id": "none", "name": "WHSC1, WHSC1L1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703368", "map_id": "none", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10702952", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702945", "map_id": "none", "name": "Me2K37-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698670", "map_id": "none", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698667", "map_id": "none", "name": "Homologues of KDM1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q556K4", "map_id": "Q556K4", "name": "maoC-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272584", "map_id": "DDB_G0272584", "name": "maoC-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556K3", "map_id": "Q556K3", "name": "maoB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272582", "map_id": "DDB_G0272582", "name": "maoB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699592", "map_id": "none", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699570", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699589", "map_id": "none", "name": "HAT1:RBBP7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86J12", "map_id": "Q86J12", "name": "HAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274269", "map_id": "DDB_G0274269", "name": "HAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725840", "map_id": "none", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699922", "map_id": "none", "name": "Sin3A complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54NX4", "map_id": "Q54NX4", "name": "SAP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285057", "map_id": "DDB_G0285057", "name": "SAP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QG3", "map_id": "Q54QG3", "name": "SAP30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283845", "map_id": "DDB_G0283845", "name": "SAP30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9679795", "map_id": "none", "name": "HDAC2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7489", "map_id": "LigandDisplayForward?ligandId=7489", "name": "LigandDisplayForward?ligandId=7489", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7009", "map_id": "LigandDisplayForward?ligandId=7009", "name": "LigandDisplayForward?ligandId=7009", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7006", "map_id": "LigandDisplayForward?ligandId=7006", "name": "LigandDisplayForward?ligandId=7006", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6852", "map_id": "LigandDisplayForward?ligandId=6852", "name": "LigandDisplayForward?ligandId=6852", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7496", "map_id": "LigandDisplayForward?ligandId=7496", "name": "LigandDisplayForward?ligandId=7496", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10699925", "map_id": "none", "name": "HDAC1:2-containing complex:HDAC2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10701685", "map_id": "none", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701663", "map_id": "none", "name": "Me2sR3-histone H3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701077", "map_id": "Q54KL5", "name": "wdr5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10701683", "map_id": "none", "name": "WDR5:Me2sR3-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10701512", "map_id": "none", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701458", "map_id": "none", "name": "MeR12-histone H2A, Histone H2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701510", "map_id": "none", "name": "Me2aR12-histone H2A, MeR12-histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10701271", "map_id": "none", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10703381", "map_id": "none", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10702931", "map_id": "none", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702928", "map_id": "none", "name": "WHSC1L1, Core MLL complex, SMYD3, SETD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703014", "map_id": "none", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10700840", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700830", "map_id": "none", "name": "Me2K10-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700832", "map_id": "none", "name": "MeK10-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700837", "map_id": "Q54K96", "name": "jcdg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287513", "map_id": "DDB_G0287513", "name": "jcdg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701689", "map_id": "none", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699587", "map_id": "none", "name": "Homologues of RBBP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701687", "map_id": "none", "name": "RBBP7:Replicative histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703379", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700868", "map_id": "O77033", "name": "trfA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269194", "map_id": "DDB_G0269194", "name": "trfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10700873", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700866", "map_id": "none", "name": "MeK28-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10699111", "map_id": "none", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696626", "map_id": "O15819", "name": "H3a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699070", "map_id": "O15819", "name": "H3a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699108", "map_id": "none", "name": "KAT7:ING4,5 dimers:MEAF6:PHF17,(15,16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698695", "map_id": "none", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698686", "map_id": "none", "name": "CCND1:CDK4:PRMT5:WDR77", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700892", "map_id": "none", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700884", "map_id": "none", "name": "Me3K10-histone H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700889", "map_id": "Q54HS3", "name": "set1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10703012", "map_id": "none", "name": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10703377", "map_id": "none", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10703375", "map_id": "none", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703373", "map_id": "none", "name": "Me2sR9-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10699927", "map_id": "none", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699878", "map_id": "none", "name": "Acetylated core histone octamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10699884", "map_id": "none", "name": "Core histone octamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10702957", "map_id": "none", "name": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10699946", "map_id": "none", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699943", "map_id": "none", "name": "Homologues of HDAC10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10682182", "map_id": "none", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_194276", "map_id": "CHEBI:16110", "name": "phosphatidylcholines", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171149", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_194236", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171076", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10682179", "map_id": "Q54XE3", "name": "LCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10682338", "map_id": "none", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682335", "map_id": "none", "name": "ABCG1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54T02", "map_id": "Q54T02", "name": "abcG24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282103", "map_id": "DDB_G0282103", "name": "abcG24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701034", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701011", "map_id": "none", "name": "p-S326-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701031", "map_id": "none", "name": "mTORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10701013", "map_id": "none", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700995", "map_id": "none", "name": "HSF1 trimer:target gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701001", "map_id": "none", "name": "Heat shock inducible proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701006", "map_id": "none", "name": "p-S230-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10684049", "map_id": "none", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684047", "map_id": "none", "name": "Rap1-GTP:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10687177", "map_id": "none", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674711", "map_id": "P54632", "name": "fttB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683990", "map_id": "none", "name": "Homologues of RAP1GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54SS8", "map_id": "Q54SS8", "name": "rapgapB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282247", "map_id": "DDB_G0282247", "name": "rapgapB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869V0", "map_id": "Q869V0", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291510", "map_id": "DDB_G0291510", "name": "SIPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AN8", "map_id": "Q55AN8", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EH3", "map_id": "Q54EH3", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RS9", "map_id": "Q54RS9", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RT1", "map_id": "Q54RT1", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q75", "map_id": "Q54Q75", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75J96", "map_id": "Q75J96", "name": "rapgap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271734", "map_id": "DDB_G0271734", "name": "rapgap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683995", "map_id": "none", "name": "RAP1GAP2:14-3-3beta, zeta", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687175", "map_id": "none", "name": "Homologues of p-S7-RAP1GAP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684035", "map_id": "none", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684033", "map_id": "none", "name": "Rap1 cAMP-GEFs:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10683997", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683992", "map_id": "none", "name": "Rap1 GTPase-activating proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10675956", "map_id": "none", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675951", "map_id": "none", "name": "OGG1:(8oxoG:Cyt)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110242", "map_id": "CHEBI:44605", "name": "8oxoG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10675977", "map_id": "none", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675972", "map_id": "none", "name": "MUTYH:(8oxoG:Ade)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXP7", "map_id": "Q1ZXP7", "name": "MYH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270764", "map_id": "DDB_G0270764", "name": "MYH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675974", "map_id": "none", "name": "MUTYH:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5635947", "map_id": "CHEBI:16708", "name": "Ade", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10711308", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10711305", "map_id": "none", "name": "keratinocyte LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10685610", "map_id": "none", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685607", "map_id": "none", "name": "pPAK1:Rac1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10687031", "map_id": "none", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10687023", "map_id": "Q54JR7", "name": "AGER", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10687027", "map_id": "none", "name": "AGER ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:53014", "map_id": "CHEBI:53014", "name": "CHEBI:53014", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60125", "map_id": "CHEBI:60125", "name": "CHEBI:60125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687029", "map_id": "none", "name": "AGER ligands:AGER", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10716012", "map_id": "none", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10716000", "map_id": "none", "name": "RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54B89", "map_id": "Q54B89", "name": "SNAPC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293830", "map_id": "DDB_G0293830", "name": "SNAPC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716009", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676885", "map_id": "none", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676872", "map_id": "Q6S000", "name": "kif12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268258", "map_id": "DDB_G0268258", "name": "phospho-kif12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676876", "map_id": "Q6S000", "name": "phospho-kif12", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10676923", "map_id": "none", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676918", "map_id": "Q6S000", "name": "kif12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10676921", "map_id": "Q6S000", "name": "phospho-kif12", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10726046", "map_id": "none", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721285", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9714134", "map_id": "none", "name": "NFE2L2 inducers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7045", "map_id": "LigandDisplayForward?ligandId=7045", "name": "LigandDisplayForward?ligandId=7045", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5786", "map_id": "LigandDisplayForward?ligandId=5786", "name": "LigandDisplayForward?ligandId=5786", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=6569", "map_id": "LigandDisplayForward?ligandId=6569", "name": "LigandDisplayForward?ligandId=6569", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10726044", "map_id": "none", "name": "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10682925", "map_id": "none", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8954997", "map_id": "CHEBI:1582", "name": "3MT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9677992", "map_id": "CHEBI:545959", "name": "HVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10682923", "map_id": "none", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9677997", "map_id": "CHEBI:41941", "name": "DOPAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10683515", "map_id": "none", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10683513", "map_id": "none", "name": "PEX19:ABCD1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q555I0", "map_id": "Q555I0", "name": "pex19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274873", "map_id": "DDB_G0274873", "name": "pex19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683495", "map_id": "Q54U86", "name": "pex3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0281213", "map_id": "DDB_G0281213", "name": "pex3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683511", "map_id": "Q555I0", "name": "pex19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10683487", "map_id": "none", "name": "ABCD1-3 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10691278", "map_id": "none", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10691275", "map_id": "none", "name": "ABCG4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10704829", "map_id": "none", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_382539", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10704826", "map_id": "none", "name": "Homologues of ABCB4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10691271", "map_id": "none", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1454930", "map_id": "CHEBI:25696", "name": "organic anion", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1454919", "map_id": "CHEBI:25696", "name": "organic anion", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10691268", "map_id": "none", "name": "ABCCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10716905", "map_id": "none", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10716902", "map_id": "none", "name": "Homologues of ABCA5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q8T6J2", "map_id": "Q8T6J2", "name": "abcA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274119", "map_id": "DDB_G0274119", "name": "abcA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BT5", "map_id": "Q54BT5", "name": "abcA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293436", "map_id": "DDB_G0293436", "name": "abcA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6J5", "map_id": "Q8T6J5", "name": "abcA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267438", "map_id": "DDB_G0267438", "name": "abcA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555Z5", "map_id": "Q555Z5", "name": "abcA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274121", "map_id": "DDB_G0274121", "name": "abcA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6J1", "map_id": "Q8T6J1", "name": "abcA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291245", "map_id": "DDB_G0291245", "name": "abcA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R52", "map_id": "Q54R52", "name": "abcA10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283387", "map_id": "DDB_G0283387", "name": "abcA10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T5Z7", "map_id": "Q8T5Z7", "name": "abcA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BC0", "map_id": "Q55BC0", "name": "abcA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271138", "map_id": "DDB_G0271138", "name": "abcA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10705130", "map_id": "none", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5682283", "map_id": "CHEBI:18059", "name": "lipids", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5229279", "map_id": "CHEBI:18059", "name": "lipids", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10705127", "map_id": "none", "name": "Homologues of ABCA12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682286", "map_id": "none", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_265784", "map_id": "none", "name": "sterols", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:26125", "map_id": "CHEBI:26125", "name": "CHEBI:26125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265781", "map_id": "none", "name": "sterols", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10682283", "map_id": "none", "name": "ABCG5:ABCG8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55DW4", "map_id": "Q55DW4", "name": "abcG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269214", "map_id": "DDB_G0269214", "name": "abcG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10691341", "map_id": "none", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1131652", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1467459", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10691338", "map_id": "none", "name": "ABCA8/B1/B5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10683474", "map_id": "none", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10683471", "map_id": "none", "name": "Heme transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q8T9W2", "map_id": "Q8T9W2", "name": "abcB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292554", "map_id": "DDB_G0292554", "name": "abcB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701720", "map_id": "none", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701716", "map_id": "Q8T6B4", "name": "abcF4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267436", "map_id": "DDB_G0267436", "name": "abcF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701718", "map_id": "none", "name": "ABCF1:EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T6B4", "map_id": "Q8T6B4", "name": "abcF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690498", "map_id": "none", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10690495", "map_id": "none", "name": "ABCA cholesterol transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10690500", "map_id": "none", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10691362", "map_id": "none", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74000", "compartment_display": "photoreceptor outer segment membrane" }, { "id": "species_2466098", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10691359", "map_id": "none", "name": "Homologues of ABCA4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10683490", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10677433", "map_id": "none", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677430", "map_id": "Q54VB2", "name": "phospho-p-S939,S1130,T1462-TSC2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10722655", "map_id": "none", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722652", "map_id": "none", "name": "p21 RAS:GTP:RASA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722657", "map_id": "none", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10716950", "map_id": "none", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10716947", "map_id": "none", "name": "p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GR7", "map_id": "Q55GR7", "name": "elmoF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267548", "map_id": "DDB_G0267548", "name": "elmoF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WH5", "map_id": "Q54WH5", "name": "elmoE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279657", "map_id": "DDB_G0279657", "name": "elmoE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RS7", "map_id": "Q54RS7", "name": "elmoC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282949", "map_id": "DDB_G0282949", "name": "elmoC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YW1", "map_id": "Q54YW1", "name": "elmoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278051", "map_id": "DDB_G0278051", "name": "elmoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW4", "map_id": "Q54NW4", "name": "phospho-limB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284863", "map_id": "DDB_G0284863", "name": "phospho-limB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716247", "map_id": "none", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716238", "map_id": "none", "name": "RAB6:GDP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10716244", "map_id": "none", "name": "RAB6:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716664", "map_id": "none", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716608", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10716662", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716705", "map_id": "none", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716701", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10716703", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716764", "map_id": "none", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716751", "map_id": "none", "name": "RAB43:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10716762", "map_id": "Q54YL8", "name": "USP6NL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278181", "map_id": "DDB_G0278181", "name": "USP6NL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716753", "map_id": "none", "name": "RAB43:GTP:USP6NL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q54YL8", "map_id": "Q54YL8", "name": "USP6NL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10716760", "map_id": "none", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716757", "map_id": "none", "name": "RAB43:GDP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716424", "map_id": "none", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716420", "map_id": "none", "name": "TMF1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556B3", "map_id": "Q556B3", "name": "TMF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274785", "map_id": "DDB_G0274785", "name": "TMF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716405", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q55E69", "map_id": "Q55E69", "name": "sys1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269368", "map_id": "DDB_G0269368", "name": "sys1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JB7", "map_id": "Q54JB7", "name": "arl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288163", "map_id": "DDB_G0288163", "name": "arl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QU7", "map_id": "Q54QU7", "name": "arlD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283631", "map_id": "DDB_G0283631", "name": "arlD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716422", "map_id": "none", "name": "AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716667", "map_id": "none", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716530", "map_id": "Q54PW2", "name": "syn6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10716540", "map_id": "none", "name": "Homologues of VTI1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10716596", "map_id": "Q54GB3", "name": "sybB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10716532", "map_id": "Q551H5", "name": "STX16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "reaction_10716407", "map_id": "none", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716399", "map_id": "none", "name": "MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716391", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716240", "map_id": "none", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716220", "map_id": "none", "name": "RAB6:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716232", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10716413", "map_id": "none", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10716411", "map_id": "none", "name": "AcM-ARFRP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10716381", "map_id": "Q55E69", "name": "sys1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "reaction_10721886", "map_id": "none", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_8949232", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8949220", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10721883", "map_id": "none", "name": "MCU complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54LT0", "map_id": "Q54LT0", "name": "MCUB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286429", "map_id": "DDB_G0286429", "name": "MCUB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JS1", "map_id": "Q54JS1", "name": "MICU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287825", "map_id": "DDB_G0287825", "name": "MICU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685511", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685508", "map_id": "none", "name": "SLC39A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55EA1", "map_id": "Q55EA1", "name": "zntD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269326", "map_id": "DDB_G0269326", "name": "zntD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB9", "map_id": "Q54MB9", "name": "zntC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286049", "map_id": "DDB_G0286049", "name": "zntC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697358", "map_id": "none", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697356", "map_id": "none", "name": "Collagen type I fibril with hydroxyallysines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10676611", "map_id": "none", "name": "Collagen type I fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697305", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10696943", "map_id": "none", "name": "Collagen IX is cross-linked to the surface of collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10696939", "map_id": "none", "name": "Collagen type IX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10691415", "map_id": "none", "name": "Collagen type II fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10696941", "map_id": "none", "name": "Collagen type II fibril:Collagen type IX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10698054", "map_id": "none", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10692249", "map_id": "none", "name": "Collagen IV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10698047", "map_id": "none", "name": "Collagen type IV networks with sulfilimine cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10698051", "map_id": "none", "name": "PXDN:Br-", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q6TMK4", "map_id": "Q6TMK4", "name": "poxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:15858", "map_id": "CHEBI:15858", "name": "CHEBI:15858", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10697211", "map_id": "none", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697183", "map_id": "none", "name": "Collagen type I fibrils with lysino-5-ketonorleucine cross-links", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697099", "map_id": "none", "name": "Collagen type I fibrils with deH-HLNL cross-links", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697209", "map_id": "none", "name": "Collagen type I fibrils with lysyl-pyrrole cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10696855", "map_id": "none", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10696849", "map_id": "none", "name": "Network forming tropocollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10696853", "map_id": "none", "name": "Collagen networks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697334", "map_id": "none", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10694584", "map_id": "none", "name": "Collagen type I fibril with allysines", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697103", "map_id": "none", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697101", "map_id": "none", "name": "Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10696859", "map_id": "none", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10696851", "map_id": "none", "name": "Collagen type X network", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10696857", "map_id": "none", "name": "Collagen type X:type II fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697360", "map_id": "none", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10697250", "map_id": "none", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10691593", "map_id": "none", "name": "Collagen type XI fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697248", "map_id": "none", "name": "Collagen type XI fibril:Collagen type II fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697332", "map_id": "none", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697330", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697414", "map_id": "none", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697412", "map_id": "none", "name": "Collagen type I fibrils with hydroxylysyl-pyrrole cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697166", "map_id": "none", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697164", "map_id": "none", "name": "Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10697387", "map_id": "none", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697385", "map_id": "none", "name": "Collagen type I fibrils with lysyl-pyridinoline cross-links", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10696823", "map_id": "none", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10691599", "map_id": "none", "name": "Collagen fibrils", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10696821", "map_id": "none", "name": "Collagen fibres", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10691601", "map_id": "none", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10691589", "map_id": "none", "name": "Tropocollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10676916", "map_id": "none", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670658", "map_id": "none", "name": "Homologues of WEE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ZN3", "map_id": "Q54ZN3", "name": "WEE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282417", "map_id": "DDB_G0282417", "name": "WEE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SK3", "map_id": "Q54SK3", "name": "WEE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10676914", "map_id": "none", "name": "Homologues of p-S53-WEE1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676895", "map_id": "none", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676887", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10676890", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10677114", "map_id": "none", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10677109", "map_id": "Q54E34", "name": "PKMYT1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291842", "map_id": "DDB_G0291842", "name": "phospho-p-PKMYT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677112", "map_id": "Q54E34", "name": "phospho-p-PKMYT1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10697270", "map_id": "none", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697266", "map_id": "none", "name": "LTBPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54YP0", "map_id": "Q54YP0", "name": "LTBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278613", "map_id": "DDB_G0278613", "name": "LTBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697268", "map_id": "none", "name": "LTBPs:Fibrillin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10695849", "map_id": "none", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10695819", "map_id": "none", "name": "Fibrillin peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10695847", "map_id": "none", "name": "Fibrillin 1,2,(3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10724643", "map_id": "none", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724639", "map_id": "P25323", "name": "mlkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279925", "map_id": "DDB_G0279925", "name": "mlkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724641", "map_id": "none", "name": "CAMK1:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P25323", "map_id": "P25323", "name": "mlkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724634", "map_id": "none", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724627", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724631", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10726201", "map_id": "none", "name": "CDK4 inhibitors bind CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9754127", "map_id": "none", "name": "CDK4 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=7938", "map_id": "LigandDisplayForward?ligandId=7938", "name": "LigandDisplayForward?ligandId=7938", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5950", "map_id": "LigandDisplayForward?ligandId=5950", "name": "LigandDisplayForward?ligandId=5950", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9923", "map_id": "LigandDisplayForward?ligandId=9923", "name": "LigandDisplayForward?ligandId=9923", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=11189", "map_id": "LigandDisplayForward?ligandId=11189", "name": "LigandDisplayForward?ligandId=11189", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7380", "map_id": "LigandDisplayForward?ligandId=7380", "name": "LigandDisplayForward?ligandId=7380", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5969", "map_id": "LigandDisplayForward?ligandId=5969", "name": "LigandDisplayForward?ligandId=5969", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7379", "map_id": "LigandDisplayForward?ligandId=7379", "name": "LigandDisplayForward?ligandId=7379", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10313", "map_id": "LigandDisplayForward?ligandId=10313", "name": "LigandDisplayForward?ligandId=10313", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=10426", "map_id": "LigandDisplayForward?ligandId=10426", "name": "LigandDisplayForward?ligandId=10426", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5707", "map_id": "LigandDisplayForward?ligandId=5707", "name": "LigandDisplayForward?ligandId=5707", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7744", "map_id": "LigandDisplayForward?ligandId=7744", "name": "LigandDisplayForward?ligandId=7744", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=9626", "map_id": "LigandDisplayForward?ligandId=9626", "name": "LigandDisplayForward?ligandId=9626", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7383", "map_id": "LigandDisplayForward?ligandId=7383", "name": "LigandDisplayForward?ligandId=7383", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7382", "map_id": "LigandDisplayForward?ligandId=7382", "name": "LigandDisplayForward?ligandId=7382", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:9933545", "map_id": "pubchem.compound:9933545", "name": "pubchem.compound:9933545", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8203", "map_id": "LigandDisplayForward?ligandId=8203", "name": "LigandDisplayForward?ligandId=8203", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=7934", "map_id": "LigandDisplayForward?ligandId=7934", "name": "LigandDisplayForward?ligandId=7934", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5680", "map_id": "LigandDisplayForward?ligandId=5680", "name": "LigandDisplayForward?ligandId=5680", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10670762", "map_id": "none", "name": "p-T172-CDK4:CCND", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670773", "map_id": "none", "name": "p-T172-CDK4:CCND:CDK4 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10723600", "map_id": "none", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698648", "map_id": "none", "name": "E2F1,E2F2,E2F3:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10723598", "map_id": "none", "name": "RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2:", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670387", "map_id": "none", "name": "Cyclin E:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670764", "map_id": "none", "name": "p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10721692", "map_id": "none", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721688", "map_id": "none", "name": "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10673933", "map_id": "none", "name": "CAK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670637", "map_id": "none", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10670633", "map_id": "none", "name": "CCNE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10670619", "map_id": "P34112", "name": "cdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10670635", "map_id": "none", "name": "CCNE:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10690366", "map_id": "none", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690027", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10690363", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54W95", "map_id": "Q54W95", "name": "PPP2R3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279813", "map_id": "DDB_G0279813", "name": "PPP2R3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q99", "map_id": "Q54Q99", "name": "phr2aB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283905", "map_id": "DDB_G0283905", "name": "phr2aB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BX1", "map_id": "Q54BX1", "name": "PPP2R2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293386", "map_id": "DDB_G0293386", "name": "PPP2R2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678594", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678224", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678592", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10676508", "map_id": "none", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676480", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113656", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10676482", "map_id": "none", "name": "RB1:RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676505", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10670666", "map_id": "none", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670641", "map_id": "none", "name": "CCNE:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670646", "map_id": "none", "name": "Cyclin E:p-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10670664", "map_id": "C7FZZ4", "name": "CABLES1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0302543", "map_id": "DDB_G0302543", "name": "CABLES1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721690", "map_id": "none", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10721670", "map_id": "none", "name": "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10678230", "map_id": "none", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10678226", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10678228", "map_id": "Q54QM6", "name": "cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10670783", "map_id": "none", "name": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670683", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10670781", "map_id": "none", "name": "p-T177-CDK6:CCND:CDK6 inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10698510", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10678242", "map_id": "none", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10678238", "map_id": "none", "name": "CDC25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10678240", "map_id": "none", "name": "CDC25", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679206", "map_id": "none", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679202", "map_id": "none", "name": "E2F1/E2F3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10679204", "map_id": "none", "name": "CCNA:p-T160-CDK2:E2F1/E2F3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10717991", "map_id": "none", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717986", "map_id": "none", "name": "SCF-FBXL7:PolyUb-AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717891", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10718380", "map_id": "none", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10718364", "map_id": "none", "name": "MeL-PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_8857797", "map_id": "CHEBI:17790", "name": "methanol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10718377", "map_id": "Q54TN3", "name": "ppme1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281651", "map_id": "DDB_G0281651", "name": "ppme1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696428", "map_id": "none", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10696414", "map_id": "Q54QV9", "name": "ARPP19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283571", "map_id": "DDB_G0283571", "name": "ARPP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10696417", "map_id": "Q54QV9", "name": "phospho-p-S62-ARPP19", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10696425", "map_id": "Q552E9", "name": "phospho-pkgA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0276157", "map_id": "DDB_G0276157", "name": "phospho-pkgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10678234", "map_id": "none", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10678232", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10697660", "map_id": "none", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10697640", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10697648", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10697657", "map_id": "none", "name": "ESCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54W25", "map_id": "Q54W25", "name": "ESCO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279959", "map_id": "DDB_G0279959", "name": "ESCO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690017", "map_id": "none", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690015", "map_id": "none", "name": "E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10690013", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10726199", "map_id": "none", "name": "CDK6 inhibitors bind CDK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10670751", "map_id": "none", "name": "p-T177-CDK6:CCND", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_9754132", "map_id": "none", "name": "CDK6 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10717895", "map_id": "none", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10678761", "map_id": "Q54WX4", "name": "aurK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10717893", "map_id": "none", "name": "SCF-FBXL7:AURKA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679247", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10677004", "map_id": "none", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10717989", "map_id": "none", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10690392", "map_id": "none", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679187", "map_id": "none", "name": "CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B0G102", "map_id": "B0G102", "name": "cks1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271642", "map_id": "DDB_G0271642", "name": "cks1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10690390", "map_id": "none", "name": "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10690031", "map_id": "none", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690029", "map_id": "none", "name": "E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679253", "map_id": "none", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679251", "map_id": "none", "name": "CCNE:p-T160-CDK2:hypophosphorylated RB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679256", "map_id": "none", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10697703", "map_id": "none", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10697699", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Centromere", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10697701", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Centromere", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697598", "map_id": "none", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10697587", "map_id": "Q54G81", "name": "ESPL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290325", "map_id": "DDB_G0290325", "name": "ESPL1(1-1506)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697595", "map_id": "none", "name": "ESPL1 Autocleaved", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54G81", "map_id": "Q54G81", "name": "ESPL1(1-1506)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10670675", "map_id": "none", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10725467", "map_id": "none", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725465", "map_id": "Q54FX2", "name": "rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10679227", "map_id": "none", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679224", "map_id": "none", "name": "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678793", "map_id": "none", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10678789", "map_id": "none", "name": "CCNA:p-Y15-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10678791", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697034", "map_id": "none", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10697026", "map_id": "none", "name": "p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10697031", "map_id": "none", "name": "p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10697509", "map_id": "none", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10697504", "map_id": "Q54QV9", "name": "ENSA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10697507", "map_id": "Q54QV9", "name": "phospho-p-S67-ENSA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10721628", "map_id": "none", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674818", "map_id": "P34112", "name": "cdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721624", "map_id": "none", "name": "Cyclin D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721626", "map_id": "none", "name": "CDK4,CDK6:CCND", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10718372", "map_id": "none", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10718369", "map_id": "Q54J74", "name": "LCMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0288271", "map_id": "DDB_G0288271", "name": "LCMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10690397", "map_id": "none", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690394", "map_id": "none", "name": "Ub-p-T401,S672,1035-RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676510", "map_id": "none", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10679215", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10679212", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679208", "map_id": "none", "name": "FZR1,p-S795-RB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10679210", "map_id": "none", "name": "p-FZR1,p-RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679193", "map_id": "none", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10679191", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10678870", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10690368", "map_id": "none", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10678849", "map_id": "none", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10697448", "map_id": "none", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697444", "map_id": "none", "name": "Transthyretin tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54LD6", "map_id": "Q54LD6", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286691", "map_id": "DDB_G0286691", "name": "TTR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10697446", "map_id": "none", "name": "HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10721829", "map_id": "none", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10692649", "map_id": "none", "name": "4-Hyp collagen propeptides:P4HB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54UW6", "map_id": "Q54UW6", "name": "P4HB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280773", "map_id": "DDB_G0280773", "name": "P4HB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10692647", "map_id": "none", "name": "4-Hyp collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10692513", "map_id": "Q54UW6", "name": "P4HB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10721764", "map_id": "none", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695220", "map_id": "Q54QY4", "name": "GalHyl-COL22A1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10695222", "map_id": "none", "name": "C-linked procollagen type XXI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721774", "map_id": "none", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694722", "map_id": "none", "name": "Alpha-2(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694792", "map_id": "none", "name": "Alpha-3(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694768", "map_id": "none", "name": "Alpha-6(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694746", "map_id": "none", "name": "Alpha-5(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694814", "map_id": "none", "name": "Alpha-4(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694700", "map_id": "none", "name": "Alpha-1(IV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694818", "map_id": "none", "name": "C-linked procollagen type IV trimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10694524", "map_id": "none", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10692579", "map_id": "none", "name": "Collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10692581", "map_id": "none", "name": "P4HB:Collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721748", "map_id": "none", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694886", "map_id": "none", "name": "Alpha-3(V) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694840", "map_id": "none", "name": "Alpha-1(V) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694862", "map_id": "none", "name": "Alpha-2(V) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694892", "map_id": "none", "name": "C-linked procollagen type V trimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721766", "map_id": "none", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695286", "map_id": "none", "name": "Alpha-1(XXIV) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695288", "map_id": "none", "name": "C-linked procollagen type XXIV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721776", "map_id": "none", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695072", "map_id": "none", "name": "Alpha-2(XI) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694652", "map_id": "none", "name": "Alpha-1(II) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695050", "map_id": "none", "name": "Alpha-1(XI) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695074", "map_id": "none", "name": "C-linked procollagen type XI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721742", "map_id": "none", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694914", "map_id": "none", "name": "Alpha-1(VIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694936", "map_id": "none", "name": "Alpha-2(VIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694938", "map_id": "none", "name": "C-linked procollagen type VIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721738", "map_id": "none", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694606", "map_id": "none", "name": "Alpha-1(I) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694628", "map_id": "none", "name": "Alpha-2(I) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694630", "map_id": "none", "name": "C-linked procollagen type I trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721772", "map_id": "none", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694654", "map_id": "none", "name": "C-linked procollagen type II trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10697502", "map_id": "none", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10697498", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens 1,2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697500", "map_id": "none", "name": "Laminins with gamma-1, gamma-3:Nidogens:Collagen type IV network", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10721768", "map_id": "none", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695096", "map_id": "none", "name": "Alpha-1(XIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695098", "map_id": "none", "name": "C-linked procollagen type XIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721750", "map_id": "none", "name": "Association of procollagen type XVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695168", "map_id": "none", "name": "Alpha-1(XVII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695170", "map_id": "none", "name": "C-linked procollagen type XVII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721752", "map_id": "none", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695240", "map_id": "none", "name": "Alpha-1(XXII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695242", "map_id": "none", "name": "C-linked procollagen type XXII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10700154", "map_id": "none", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10700150", "map_id": "none", "name": "Endostatin dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10697474", "map_id": "none", "name": "Laminin-111", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10700152", "map_id": "none", "name": "Laminin-111:Endostatin dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10693910", "map_id": "none", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10693906", "map_id": "none", "name": "Alpha-1(XXVIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10693908", "map_id": "none", "name": "C-linked procollagen type XXVIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721746", "map_id": "none", "name": "Association of procollagen type XXIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695262", "map_id": "none", "name": "Alpha-1(XXIII) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695264", "map_id": "none", "name": "C-linked procollagen type XXIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10694522", "map_id": "none", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10694218", "map_id": "none", "name": "Fibrillar procollagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10694510", "map_id": "none", "name": "Fibrillar procollagens -N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10694515", "map_id": "O15916", "name": "rsc22", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0279795", "map_id": "DDB_G0279795", "name": "rsc22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696111", "map_id": "none", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10696025", "map_id": "none", "name": "Transmembrane collagens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10696109", "map_id": "none", "name": "Transmembrane collagens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10721762", "map_id": "none", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695310", "map_id": "none", "name": "Alpha-1(XXVII) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695312", "map_id": "none", "name": "C-linked procollagen type XXVII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10700148", "map_id": "none", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10700144", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10700146", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5:HSPG2(22-4391)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10721760", "map_id": "none", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10694676", "map_id": "none", "name": "Alpha-1(III) propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10694678", "map_id": "none", "name": "C-linked procollagen type III trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721770", "map_id": "none", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695026", "map_id": "none", "name": "Alpha-1(X) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695028", "map_id": "none", "name": "C-linked procollagen type X trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10721740", "map_id": "none", "name": "Association of procollagen type XV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695120", "map_id": "none", "name": "Alpha-1(XV) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695122", "map_id": "none", "name": "C-linked procollagen type XV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10692690", "map_id": "none", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_1650779", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_1650769", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10692687", "map_id": "none", "name": "Prolyl 4-hydroxylases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:29073", "map_id": "CHEBI:29073", "name": "CHEBI:29073", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553P3", "map_id": "Q553P3", "name": "P4HA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292888", "map_id": "DDB_G0292888", "name": "P4HA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N51", "map_id": "Q54N51", "name": "P4HA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TF2", "map_id": "Q54TF2", "name": "P4HA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CK1", "map_id": "Q54CK1", "name": "P4HA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721744", "map_id": "none", "name": "Association of procollagen type XVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10695144", "map_id": "none", "name": "Alpha-1(XVI) chains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10695146", "map_id": "none", "name": "C-linked procollagen type XVI trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10724718", "map_id": "none", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10675991", "map_id": "none", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675987", "map_id": "Q54S00", "name": "mad2l2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0282747", "map_id": "DDB_G0282747", "name": "mad2l2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675982", "map_id": "Q55AZ3", "name": "REV3L", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271608", "map_id": "DDB_G0271608", "name": "REV3L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675989", "map_id": "none", "name": "POLZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54S00", "map_id": "Q54S00", "name": "mad2l2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AZ3", "map_id": "Q55AZ3", "name": "REV3L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703141", "map_id": "none", "name": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703137", "map_id": "none", "name": "DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KS3", "map_id": "Q54KS3", "name": "POLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287149", "map_id": "DDB_G0287149", "name": "POLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703104", "map_id": "O96612", "name": "ubpB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10703139", "map_id": "none", "name": "USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675750", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10675745", "map_id": "none", "name": "SLC29A1-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10677294", "map_id": "none", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10677291", "map_id": "none", "name": "SLC25A5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O97470", "map_id": "O97470", "name": "ancA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267454", "map_id": "DDB_G0267454", "name": "ancA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686888", "map_id": "none", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727737", "map_id": "none", "name": "ligands of SLC29A4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_209789", "map_id": "CHEBI:18357", "name": "NAd", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:28918", "map_id": "CHEBI:28918", "name": "CHEBI:28918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_727774", "map_id": "none", "name": "ligands of SLC29A4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10686862", "map_id": "none", "name": "Homologues of SLC29A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10686865", "map_id": "none", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675741", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179747", "map_id": "none", "name": "ligands of SLC29A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:16040", "map_id": "CHEBI:16040", "name": "CHEBI:16040", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179742", "map_id": "none", "name": "ligands of SLC29A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10675738", "map_id": "none", "name": "SLC29A2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10686918", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10686915", "map_id": "Q869W7", "name": "slc35b4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0275061", "map_id": "DDB_G0275061", "name": "slc35b4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686876", "map_id": "none", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727782", "map_id": "none", "name": "nucleosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_727746", "map_id": "none", "name": "nucleosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686873", "map_id": "none", "name": "Homologues of SLC29A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10686884", "map_id": "none", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727753", "map_id": "CHEBI:57288", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10686881", "map_id": "Q1ZXJ4", "name": "SLC33A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0278059", "map_id": "DDB_G0278059", "name": "SLC33A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687053", "map_id": "none", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879603", "map_id": "none", "name": "T3,T4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_879628", "map_id": "none", "name": "T3,T4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687050", "map_id": "none", "name": "SLC16A2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q555W6", "map_id": "Q555W6", "name": "SLC16A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274807", "map_id": "DDB_G0274807", "name": "SLC16A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Y5", "map_id": "Q556Y5", "name": "SLC16A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686921", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742353", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10675743", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675748", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10682847", "map_id": "none", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375765", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375781", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10682818", "map_id": "none", "name": "Homologues of SLC7A2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54KK3", "map_id": "Q54KK3", "name": "SLC7A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0346922", "map_id": "DDB_G0346922", "name": "SLC7A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W03", "map_id": "Q54W03", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279983", "map_id": "DDB_G0279983", "name": "SLC7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK2", "map_id": "Q54KK2", "name": "SLC7A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F04", "map_id": "Q54F04", "name": "SLC7A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK4", "map_id": "Q54KK4", "name": "SLC7A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK5", "map_id": "Q54KK5", "name": "SLC7A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EJ9", "map_id": "Q54EJ9", "name": "ctrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291227", "map_id": "DDB_G0291227", "name": "ctrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682581", "map_id": "none", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352161", "map_id": "none", "name": "ligands of SLC16A10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352139", "map_id": "none", "name": "ligands of SLC16A10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10682578", "map_id": "none", "name": "Homologues of SLC16A10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682845", "map_id": "none", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682842", "map_id": "Q54W03", "name": "SLC7A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10682821", "map_id": "none", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10682840", "map_id": "none", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682837", "map_id": "none", "name": "Homologues of SLC7A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722317", "map_id": "none", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722313", "map_id": "Q54Q23", "name": "E2F6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10690002", "map_id": "Q7KWP1", "name": "TFDP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10722315", "map_id": "none", "name": "E2F6:TFDP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722398", "map_id": "none", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722394", "map_id": "Q54JZ0", "name": "EPC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287727", "map_id": "DDB_G0287727", "name": "EPC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10722396", "map_id": "none", "name": "E2F6:TFDP1:EPC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54JZ0", "map_id": "Q54JZ0", "name": "EPC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722387", "map_id": "none", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10690004", "map_id": "Q7KWP1", "name": "TFDP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10722385", "map_id": "none", "name": "E2F6:TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722987", "map_id": "none", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10722985", "map_id": "Q54Q23", "name": "phospho-p-S12-E2F6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10688476", "map_id": "none", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10688251", "map_id": "Q54MF7", "name": "TRIM28", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10688256", "map_id": "Q54UG9", "name": "TFIIIA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10688474", "map_id": "none", "name": "KRAB-ZNF / KAP Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UG9", "map_id": "Q54UG9", "name": "TFIIIA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10709807", "map_id": "none", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10704976", "map_id": "none", "name": "DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709804", "map_id": "none", "name": "DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703096", "map_id": "none", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703089", "map_id": "none", "name": "LIG1:POLB:SSB(3'poly-dNMP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q869E1", "map_id": "Q869E1", "name": "lig1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703093", "map_id": "none", "name": "LIG1:POLB:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709844", "map_id": "none", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709797", "map_id": "none", "name": "MDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705273", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709799", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702975", "map_id": "none", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702970", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86H44", "map_id": "Q86H44", "name": "XRCC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275653", "map_id": "DDB_G0275653", "name": "XRCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM4", "map_id": "Q54QM4", "name": "lig3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283857", "map_id": "DDB_G0283857", "name": "lig3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U78", "map_id": "Q54U78", "name": "PNKP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281229", "map_id": "DDB_G0281229", "name": "PNKP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702972", "map_id": "none", "name": "NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705284", "map_id": "none", "name": "WHSC1 binds DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700897", "map_id": "Q55FF7", "name": "WHSC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10705275", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705282", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676006", "map_id": "none", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675996", "map_id": "P51173", "name": "apeA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0277701", "map_id": "DDB_G0277701", "name": "apeA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675968", "map_id": "Q1ZXP7", "name": "MYH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10675998", "map_id": "none", "name": "APEX1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P51173", "map_id": "P51173", "name": "apeA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703099", "map_id": "none", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703074", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10703028", "map_id": "none", "name": "PARP1,PARP2 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5651834", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10703035", "map_id": "Q54Z28", "name": "PARG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0277943", "map_id": "DDB_G0277943", "name": "PARG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10711334", "map_id": "none", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709581", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q869L7", "map_id": "Q869L7", "name": "RAD23B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279421", "map_id": "DDB_G0279421", "name": "RAD23B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU9", "map_id": "Q54WU9", "name": "RAD23B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LV1", "map_id": "Q54LV1", "name": "rcbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286357", "map_id": "DDB_G0286357", "name": "rcbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10711318", "map_id": "none", "name": "SUMO1,2,3:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10711329", "map_id": "none", "name": "Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10711331", "map_id": "none", "name": "PIAS1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710378", "map_id": "none", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710373", "map_id": "none", "name": "Ub:ERCC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GG6", "map_id": "Q55GG6", "name": "ercc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267682", "map_id": "DDB_G0267682", "name": "ercc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675845", "map_id": "Q55GG6", "name": "ercc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10710375", "map_id": "Q86KB3", "name": "USP45", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10725845", "map_id": "none", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710820", "map_id": "none", "name": "TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710831", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674796", "map_id": "none", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674787", "map_id": "Q54CS9", "name": "rad50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10674792", "map_id": "Q54BN2", "name": "MRE11A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10674794", "map_id": "none", "name": "RAD50:MRE11A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710837", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710833", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54AQ1", "map_id": "Q54AQ1", "name": "ERCC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294290", "map_id": "DDB_G0294290", "name": "ERCC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10675852", "map_id": "none", "name": "ERCC1:ERCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PN5", "map_id": "Q54PN5", "name": "ercc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284419", "map_id": "DDB_G0284419", "name": "ercc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10710835", "map_id": "none", "name": "TC-NER incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709584", "map_id": "none", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709577", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710592", "map_id": "none", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710586", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710588", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674087", "map_id": "none", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674080", "map_id": "none", "name": "LIG3:XRCC1:POLB:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674084", "map_id": "none", "name": "LIG3:XRCC1:POLB:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705287", "map_id": "none", "name": "ATM phosphorylates WHSC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705277", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709814", "map_id": "none", "name": "TP53BP1 associates with H4K20Me2 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705317", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705325", "map_id": "none", "name": "DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676004", "map_id": "none", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675947", "map_id": "Q54CZ3", "name": "OGG1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10705333", "map_id": "none", "name": "ATM phosphorylates TP53BP1 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705323", "map_id": "none", "name": "DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710857", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710853", "map_id": "none", "name": "PCNA homotrimer,MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710851", "map_id": "none", "name": "POLD,POLE,POLK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710839", "map_id": "none", "name": "TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710855", "map_id": "none", "name": "TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709802", "map_id": "none", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676017", "map_id": "none", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676010", "map_id": "none", "name": "APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10674064", "map_id": "Q1ZXF2", "name": "polB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10676015", "map_id": "none", "name": "POLB:APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703020", "map_id": "none", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676029", "map_id": "none", "name": "APEX1:SSB(5'-ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676031", "map_id": "none", "name": "POLB:APEX1:SSB(5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676000", "map_id": "none", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675896", "map_id": "P53766", "name": "uglA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10703083", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703076", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54NU0", "map_id": "Q54NU0", "name": "repG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703081", "map_id": "none", "name": "FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709648", "map_id": "none", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709644", "map_id": "none", "name": "UV-DDB:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709590", "map_id": "none", "name": "XPC:RAD23:CETN2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10709646", "map_id": "none", "name": "XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710842", "map_id": "none", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676020", "map_id": "none", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674091", "map_id": "none", "name": "POLB:SSB-gap-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30977", "map_id": "CHEBI:33447", "name": "SUGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10705280", "map_id": "none", "name": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705231", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675854", "map_id": "none", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675850", "map_id": "Q54PN5", "name": "ercc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10703037", "map_id": "none", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676035", "map_id": "none", "name": "POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10703030", "map_id": "none", "name": "PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10725405", "map_id": "none", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725401", "map_id": "Q54CZ3", "name": "OGG1beta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10725403", "map_id": "Q54CZ3", "name": "OGG1beta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10709812", "map_id": "none", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709809", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705388", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703045", "map_id": "none", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703042", "map_id": "none", "name": "PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676013", "map_id": "none", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10702985", "map_id": "none", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702977", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10702982", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705330", "map_id": "none", "name": "PPP5C dephosphorylates TP53BP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705327", "map_id": "Q54RH6", "name": "PPP5C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283157", "map_id": "DDB_G0283157", "name": "PPP5C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702980", "map_id": "none", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10703079", "map_id": "none", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10710590", "map_id": "none", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709573", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10705265", "map_id": "none", "name": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705253", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10705263", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709592", "map_id": "none", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709562", "map_id": "none", "name": "RAD23", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10700558", "map_id": "none", "name": "Homologues of CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10709847", "map_id": "none", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705206", "map_id": "none", "name": "DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703207", "map_id": "none", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703190", "map_id": "none", "name": "USP1:WDR48", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10703202", "map_id": "Q54G37", "name": "usp12", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10703204", "map_id": "Q54G37", "name": "usp12", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10703188", "map_id": "Q54ZP5", "name": "WDR48", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10676002", "map_id": "none", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675889", "map_id": "Q86K43", "name": "NTH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10703022", "map_id": "none", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676038", "map_id": "none", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10709851", "map_id": "none", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10705374", "map_id": "none", "name": "p-Y142-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674096", "map_id": "none", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674093", "map_id": "none", "name": "LIG3:XRCC1:POLB:SSB-gap-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710877", "map_id": "none", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10704979", "map_id": "none", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10704974", "map_id": "none", "name": "DNA DSBs:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703091", "map_id": "none", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10703087", "map_id": "none", "name": "POLB:SSB(3'poly-dNMP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710823", "map_id": "none", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10709588", "map_id": "none", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10709586", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676022", "map_id": "none", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674078", "map_id": "none", "name": "LIG3:XRCC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10710849", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10710844", "map_id": "none", "name": "TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10710846", "map_id": "none", "name": "TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10682781", "map_id": "none", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5279533", "map_id": "CHEBI:27852", "name": "3,4-dihydroxyphenylglycolaldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "reaction_10681988", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10681985", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54W37", "map_id": "Q54W37", "name": "SLC17A3(1-498)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UX4", "map_id": "Q54UX4", "name": "SLC17A3(1-498)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681963", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10687261", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10687258", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55FI1", "map_id": "Q55FI1", "name": "gabT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268104", "map_id": "DDB_G0268104", "name": "gabT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10724738", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10724723", "map_id": "none", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724720", "map_id": "Q23917", "name": "regA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10725941", "map_id": "none", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725938", "map_id": "Q23917", "name": "regA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10684216", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684051", "map_id": "none", "name": "G-protein alpha (12/13):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10684213", "map_id": "none", "name": "G-protein alpha (12/13):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10712040", "map_id": "none", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10712037", "map_id": "none", "name": "Homologues of LPPR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10683869", "map_id": "none", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10683865", "map_id": "none", "name": "G-protein alpha (z):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10683867", "map_id": "none", "name": "G-protein alpha (z):GTP:Adenylate cyclase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725991", "map_id": "none", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10722710", "map_id": "none", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722706", "map_id": "none", "name": "RGS16,17,20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10722708", "map_id": "none", "name": "G alpha (z):GTP:RGS16,17,20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684207", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10684204", "map_id": "none", "name": "cAMP PDEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86H13", "map_id": "Q86H13", "name": "Pde4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683912", "map_id": "none", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683909", "map_id": "none", "name": "G-protein beta-gamma:PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724275", "map_id": "none", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724273", "map_id": "none", "name": "PDK1:AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722760", "map_id": "none", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10722758", "map_id": "none", "name": "G alpha (z):GDP:RGS16,17,20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10686923", "map_id": "none", "name": "G-protein alpha (z):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722770", "map_id": "none", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10698635", "map_id": "none", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_874088", "map_id": "CHEBI:16991", "name": "Double-stranded DNA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10698631", "map_id": "Q54BN2", "name": "MRE11A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10698633", "map_id": "none", "name": "MRE11:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10723428", "map_id": "none", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698604", "map_id": "Q54KG1", "name": "ddx41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287361", "map_id": "DDB_G0287361", "name": "ddx41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8982080", "map_id": "none", "name": "c-di-AMP, c-di-GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49537", "map_id": "CHEBI:49537", "name": "CHEBI:49537", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47037", "map_id": "CHEBI:47037", "name": "CHEBI:47037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10723426", "map_id": "none", "name": "DDX41:c-di-AMP, c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KG1", "map_id": "Q54KG1", "name": "ddx41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10682899", "map_id": "none", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682853", "map_id": "none", "name": "Homologues of SNAP23", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682888", "map_id": "none", "name": "Homologues of VAMP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10682894", "map_id": "none", "name": "Homologues of VAMP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682896", "map_id": "none", "name": "Vamp8:SNAP23:Syn4 Secretory granule docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702014", "map_id": "none", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_5334668", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10702010", "map_id": "none", "name": "CLAT:AP1:CLVS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "B0G185", "map_id": "B0G185", "name": "ap1s2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295711", "map_id": "DDB_G0295711", "name": "ap1s2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WW3", "map_id": "Q54WW3", "name": "ap1s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279359", "map_id": "DDB_G0279359", "name": "ap1s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HS9", "map_id": "Q54HS9", "name": "apm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289247", "map_id": "DDB_G0289247", "name": "apm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I8U2", "map_id": "Q8I8U2", "name": "ap1g1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281957", "map_id": "DDB_G0281957", "name": "ap1g1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702012", "map_id": "none", "name": "CLAT:AP1:CLVS:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10682916", "map_id": "none", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10682905", "map_id": "none", "name": "Homologues of VAMP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10682911", "map_id": "none", "name": "Homologues of VAMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682913", "map_id": "none", "name": "Vamp2:SNAP23:Syn4 Secretory granule docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10682453", "map_id": "none", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682429", "map_id": "none", "name": "Arf1-GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10682433", "map_id": "none", "name": "Arf1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10682882", "map_id": "none", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10682871", "map_id": "none", "name": "Homologues of VAMP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q86AQ7", "map_id": "Q86AQ7", "name": "vamp7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277173", "map_id": "DDB_G0277173", "name": "vamp7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW7", "map_id": "Q54NW7", "name": "vamp7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284951", "map_id": "DDB_G0284951", "name": "vamp7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682877", "map_id": "none", "name": "Homologues of VAMP7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10682879", "map_id": "none", "name": "Vamp7:SNAP23:Syn4 Plasma membrane vesicle docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10701766", "map_id": "none", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171907", "compartment_display": "endosome lumen" }, { "id": "species_10701749", "map_id": "none", "name": "AP4:APP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q54VE0", "map_id": "Q54VE0", "name": "ap4e1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280427", "map_id": "DDB_G0280427", "name": "ap4e1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPF0", "map_id": "Q9GPF0", "name": "apm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276945", "map_id": "DDB_G0276945", "name": "apm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NZ4", "map_id": "Q54NZ4", "name": "ap4s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284905", "map_id": "DDB_G0284905", "name": "ap4s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R84", "map_id": "Q54R84", "name": "ap4b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283319", "map_id": "DDB_G0283319", "name": "ap4b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701763", "map_id": "none", "name": "AP4:APP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "true" }, { "id": "reaction_10679542", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10679285", "map_id": "none", "name": "MGAM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10679281", "map_id": "none", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188980", "map_id": "CHEBI:17992", "name": "Suc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10679275", "map_id": "none", "name": "sucrase-isomaltase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722325", "map_id": "none", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8953397", "map_id": "CHEBI:16243", "name": "quercetin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8953383", "map_id": "CHEBI:16068", "name": "2PCPGCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8953399", "map_id": "CHEBI:17245", "name": "CO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10722322", "map_id": "Q557H8", "name": "PIR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0273413", "map_id": "DDB_G0273413", "name": "PIR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10679278", "map_id": "none", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10679538", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10679540", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10703366", "map_id": "none", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5659875", "map_id": "CHEBI:28189", "name": "iMal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10679288", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10695627", "map_id": "none", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10695624", "map_id": "none", "name": "PLD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10695602", "map_id": "none", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10695599", "map_id": "none", "name": "Phosphatidate phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718995", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10692772", "map_id": "none", "name": "Homologues of PIP5K1C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10718847", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718843", "map_id": "none", "name": "PICALMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Y50", "map_id": "Q54Y50", "name": "SNAP91", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278685", "map_id": "DDB_G0278685", "name": "SNAP91", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718837", "map_id": "none", "name": "VAMP2,3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10718845", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10720418", "map_id": "none", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718263", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684438", "map_id": "none", "name": "Clathrin Triskelion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10718325", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718711", "map_id": "none", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10718707", "map_id": "none", "name": "EPS15,EPN1,EPN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54EH1", "map_id": "Q54EH1", "name": "epnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291512", "map_id": "DDB_G0291512", "name": "epnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718699", "map_id": "Q9NIF3", "name": "ubqln", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267452", "map_id": "DDB_G0267452", "name": "ubqln", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718709", "map_id": "none", "name": "UNQLNs:UIM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NIF3", "map_id": "Q9NIF3", "name": "ubqln", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718568", "map_id": "none", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10718544", "map_id": "none", "name": "TOR1 hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10718532", "map_id": "P54672", "name": "apm2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718566", "map_id": "none", "name": "NEDD8-STONs:TOR1 hexamer:COP9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10718522", "map_id": "none", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718315", "map_id": "none", "name": "FCHO1,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75JD4", "map_id": "Q75JD4", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274695", "map_id": "DDB_G0274695", "name": "PACSIN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AN3", "map_id": "Q55AN3", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555L8", "map_id": "Q555L8", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GD0", "map_id": "Q54GD0", "name": "mgp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290233", "map_id": "DDB_G0290233", "name": "mgp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10681832", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718335", "map_id": "none", "name": "Homologues of SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10718319", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718317", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718337", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718577", "map_id": "none", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10709499", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10718570", "map_id": "P54672", "name": "apm2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10718347", "map_id": "none", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718343", "map_id": "none", "name": "NECAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54U74", "map_id": "Q54U74", "name": "NECAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281235", "map_id": "DDB_G0281235", "name": "NECAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718275", "map_id": "none", "name": "Homologues of AAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VV7", "map_id": "Q54VV7", "name": "AAK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280111", "map_id": "DDB_G0280111", "name": "AAK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HW6", "map_id": "Q86HW6", "name": "AAK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718345", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10719091", "map_id": "none", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10719089", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q54IA6", "map_id": "Q54IA6", "name": "AMPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288895", "map_id": "DDB_G0288895", "name": "AMPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NT2", "map_id": "Q54NT2", "name": "BIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284997", "map_id": "DDB_G0284997", "name": "BIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UC8", "map_id": "Q54UC8", "name": "SLC2A8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281155", "map_id": "DDB_G0281155", "name": "SLC2A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE9", "map_id": "Q1ZXE9", "name": "hipA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285703", "map_id": "DDB_G0285703", "name": "hipA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T867", "map_id": "Q8T867", "name": "GAK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276447", "map_id": "DDB_G0276447", "name": "GAK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10719055", "map_id": "none", "name": "HSPA8:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10719087", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10718357", "map_id": "none", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718354", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718998", "map_id": "none", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718914", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718721", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718715", "map_id": "none", "name": "AP-2 dileucine-containing cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10718717", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10718719", "map_id": "none", "name": "AP2:chlorpromazine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9648300", "map_id": "LigandDisplayForward?ligandId=83", "name": "chlorpromazine", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10718575", "map_id": "none", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10725842", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10698195", "map_id": "none", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352022", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10698192", "map_id": "Q54G87", "name": "TTYH1-3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0290313", "map_id": "DDB_G0290313", "name": "TTYH1-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698213", "map_id": "none", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2892454", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10698210", "map_id": "none", "name": "Homologues of SLC17A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10698117", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698114", "map_id": "none", "name": "ANOs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55GA1", "map_id": "Q55GA1", "name": "ANO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293626", "map_id": "DDB_G0293626", "name": "ANO3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BH1", "map_id": "Q54BH1", "name": "ANO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698178", "map_id": "none", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698175", "map_id": "none", "name": "CLCN1/2/KA/KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54C67", "map_id": "Q54C67", "name": "clcF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293130", "map_id": "DDB_G0293130", "name": "clcF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LQ4", "map_id": "Q54LQ4", "name": "clcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286491", "map_id": "DDB_G0286491", "name": "clcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698125", "map_id": "none", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2731008", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10698122", "map_id": "Q1ZXJ0", "name": "clcD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "DDB_G0278639", "map_id": "DDB_G0278639", "name": "clcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698190", "map_id": "none", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698187", "map_id": "none", "name": "TTYH2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54G87", "map_id": "Q54G87", "name": "TTYH1-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698982", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698913", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54EY0", "map_id": "Q54EY0", "name": "MCOLN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291275", "map_id": "DDB_G0291275", "name": "MCOLN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698980", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RB7", "map_id": "Q54RB7", "name": "phospho-shkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283267", "map_id": "DDB_G0283267", "name": "phospho-shkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U31", "map_id": "Q54U31", "name": "phospho-shkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281343", "map_id": "DDB_G0281343", "name": "phospho-shkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N73", "map_id": "Q54N73", "name": "phospho-7tmk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285463", "map_id": "DDB_G0285463", "name": "phospho-7tmk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y55", "map_id": "Q54Y55", "name": "phospho-shkC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278409", "map_id": "DDB_G0278409", "name": "phospho-shkC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IP4", "map_id": "Q54IP4", "name": "phospho-shkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288617", "map_id": "DDB_G0288617", "name": "phospho-shkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G43", "map_id": "Q54G43", "name": "phospho-shkE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290451", "map_id": "DDB_G0290451", "name": "phospho-shkE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725463", "map_id": "none", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698070", "map_id": "none", "name": "Homologues of ANO1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10698204", "map_id": "none", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10698201", "map_id": "none", "name": "Homologues of SLC17A3(1-498)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685792", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685551", "map_id": "none", "name": "Homologues of RHCG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685018", "map_id": "none", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429130", "map_id": "CHEBI:17268", "name": "Ins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685015", "map_id": "Q54YF6", "name": "SLC2A13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0278261", "map_id": "DDB_G0278261", "name": "SLC2A13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685539", "map_id": "none", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_432019", "map_id": "CHEBI:16199", "name": "Urea", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685536", "map_id": "none", "name": "Urea transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86AP4", "map_id": "Q86AP4", "name": "SLC14A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277263", "map_id": "DDB_G0277263", "name": "SLC14A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685554", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10685476", "map_id": "none", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_437295", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10685473", "map_id": "Q54N27", "name": "SLC31A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285545", "map_id": "DDB_G0285545", "name": "SLC31A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685794", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685565", "map_id": "Q8I0L6", "name": "rhgB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10722613", "map_id": "none", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_266099", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10722610", "map_id": "Q54T06", "name": "SLC30A10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10685568", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10685434", "map_id": "none", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10685431", "map_id": "Q869V1", "name": "nramp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0276973", "map_id": "DDB_G0276973", "name": "nramp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685563", "map_id": "none", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10685429", "map_id": "none", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_445829", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_445832", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_10685426", "map_id": "Q869V1", "name": "nramp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10685421", "map_id": "none", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_446589", "map_id": "none", "name": "MATE substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=1231", "map_id": "LigandDisplayForward?ligandId=1231", "name": "LigandDisplayForward?ligandId=1231", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_446597", "map_id": "none", "name": "MATE substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10685418", "map_id": "none", "name": "MATE1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54YM8", "map_id": "Q54YM8", "name": "SLC47A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292132", "map_id": "DDB_G0292132", "name": "SLC47A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM2", "map_id": "Q54DM2", "name": "SLC47A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687849", "map_id": "none", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687845", "map_id": "none", "name": "Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687819", "map_id": "Q54I89", "name": "upf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288923", "map_id": "DDB_G0288923", "name": "phospho-upf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687847", "map_id": "none", "name": "UPF1:eRF3 Complex on Translated mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I89", "map_id": "Q54I89", "name": "phospho-upf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687927", "map_id": "none", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687922", "map_id": "none", "name": "SMG1:UPF1:EJC:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TQ1", "map_id": "Q54TQ1", "name": "UPF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281623", "map_id": "DDB_G0281623", "name": "UPF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R12", "map_id": "Q54R12", "name": "SMG9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283447", "map_id": "DDB_G0283447", "name": "SMG9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JP6", "map_id": "Q75JP6", "name": "SMG8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272470", "map_id": "DDB_G0272470", "name": "SMG8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687924", "map_id": "none", "name": "SMG1:Phosphorylated UPF1:EJC:Translated mRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10675713", "map_id": "none", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675707", "map_id": "none", "name": "TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675016", "map_id": "none", "name": "TFIIIB-Type 1 and 2 Promoter Selective Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675711", "map_id": "none", "name": "TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675717", "map_id": "none", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675715", "map_id": "none", "name": "RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675709", "map_id": "none", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_83747", "map_id": "none", "name": "DNA with RNA Polymerase III Type 2 Closed Promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10675045", "map_id": "none", "name": "TFIIIC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10679857", "map_id": "none", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10679855", "map_id": "none", "name": "Homologues of p-T,Y-MAPK8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10681841", "map_id": "none", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10681837", "map_id": "none", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10681382", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10681834", "map_id": "none", "name": "GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10704220", "map_id": "none", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704091", "map_id": "Q55C68", "name": "BRAP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270200", "map_id": "DDB_G0270200", "name": "Q55C68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704218", "map_id": "none", "name": "p21 RAS:GTP:BRAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55C68", "map_id": "Q55C68", "name": "Q55C68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704343", "map_id": "none", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704339", "map_id": "Q54QK0", "name": "PEBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283803", "map_id": "DDB_G0283803", "name": "PEBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704334", "map_id": "none", "name": "p21RAS:GTP:activated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10704341", "map_id": "none", "name": "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54QK0", "map_id": "Q54QK0", "name": "PEBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704230", "map_id": "none", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704227", "map_id": "none", "name": "p21 RAS:GTP:ub-BRAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703817", "map_id": "none", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703808", "map_id": "none", "name": "'activator' RAF:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10703810", "map_id": "none", "name": "p21 RAS:GTP:'activator' RAF:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10703815", "map_id": "Q54GI9", "name": "phbA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290123", "map_id": "DDB_G0290123", "name": "phbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725190", "map_id": "none", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725136", "map_id": "none", "name": "pro-RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2530486", "map_id": "CHEBI:50277", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10725178", "map_id": "none", "name": "S-Farn-proRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10725185", "map_id": "none", "name": "FNTA:FNTB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RT9", "map_id": "Q54RT9", "name": "fntA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283053", "map_id": "DDB_G0283053", "name": "fntA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D51", "map_id": "Q55D51", "name": "fntB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270948", "map_id": "DDB_G0270948", "name": "fntB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725188", "map_id": "none", "name": "FNTA:FNTB:FTase inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=6531", "map_id": "LigandDisplayForward?ligandId=6531", "name": "LigandDisplayForward?ligandId=6531", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8025", "map_id": "LigandDisplayForward?ligandId=8025", "name": "LigandDisplayForward?ligandId=8025", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8024", "map_id": "LigandDisplayForward?ligandId=8024", "name": "LigandDisplayForward?ligandId=8024", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "pubchem.compound:216453", "map_id": "pubchem.compound:216453", "name": "pubchem.compound:216453", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8028", "map_id": "LigandDisplayForward?ligandId=8028", "name": "LigandDisplayForward?ligandId=8028", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8026", "map_id": "LigandDisplayForward?ligandId=8026", "name": "LigandDisplayForward?ligandId=8026", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=8030", "map_id": "LigandDisplayForward?ligandId=8030", "name": "LigandDisplayForward?ligandId=8030", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704105", "map_id": "none", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704084", "map_id": "none", "name": "dephosphorylated \"receiver\" RAF/KSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704086", "map_id": "none", "name": "p21 RAS:GTP:homo/heterodimerized RAF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10704103", "map_id": "none", "name": "Homologues of MAP3K11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704093", "map_id": "none", "name": "BRAP:KSR1:MARK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725346", "map_id": "none", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678450", "map_id": "none", "name": "Homologues of S-Farn-Me KRAS4B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10725344", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10725342", "map_id": "none", "name": "Homologues of pS181-S-Farn-Me KRAS4B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725393", "map_id": "none", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10725391", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703913", "map_id": "none", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703911", "map_id": "none", "name": "dephosphorylated inactive RAFS:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10674713", "map_id": "none", "name": "YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10703909", "map_id": "none", "name": "dephosphorylated inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703705", "map_id": "none", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703686", "map_id": "none", "name": "KSR1:MARK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10703702", "map_id": "none", "name": "p-S311,S406 KSR1:MARK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10704378", "map_id": "none", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704355", "map_id": "none", "name": "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10704375", "map_id": "Q54RH6", "name": "PPP5C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10725283", "map_id": "none", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9653479", "map_id": "none", "name": "FNTB inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703885", "map_id": "none", "name": "PP2A dephosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703868", "map_id": "none", "name": "p-S311,S406 KSR1:MARK3:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10703882", "map_id": "none", "name": "p-S311 KSR1:MARK3:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703358", "map_id": "none", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703324", "map_id": "none", "name": "SPRED dimer:NF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54WD0", "map_id": "Q54WD0", "name": "ub-NF1(2-2839)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284177", "map_id": "DDB_G0284177", "name": "ub-NF1(2-2839)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q13", "map_id": "Q54Q13", "name": "ub-NF1(2-2839)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RT3", "map_id": "Q54RT3", "name": "ub-NF1(2-2839)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JJ7", "map_id": "Q86JJ7", "name": "ub-NF1(2-2839)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AR6", "map_id": "Q55AR6", "name": "nfaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271750", "map_id": "DDB_G0271750", "name": "nfaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5TJ65", "map_id": "Q5TJ65", "name": "vasp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289541", "map_id": "DDB_G0289541", "name": "vasp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703353", "map_id": "none", "name": "SPRED dimer:ub-NF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10703355", "map_id": "none", "name": "KBTBD7:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725301", "map_id": "none", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10725255", "map_id": "none", "name": "S-Farn-Me-PalmS KRAS4A, HRAS, NRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_8848337", "map_id": "CHEBI:7896", "name": "PALM(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10725294", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54F01", "map_id": "Q54F01", "name": "ABHD17C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291205", "map_id": "DDB_G0291205", "name": "ABHD17C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725296", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9647934", "map_id": "pubchem.compound:45100481", "name": "Palmostatin B", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10725093", "map_id": "none", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10725069", "map_id": "none", "name": "S-Farn-RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10725089", "map_id": "none", "name": "Homologues of S-Farn-Me HRAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10725091", "map_id": "none", "name": "ICMT:Zn2+:Cysmethynil", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "pubchem.compound:6918831", "map_id": "pubchem.compound:6918831", "name": "pubchem.compound:6918831", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10725304", "map_id": "none", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10703887", "map_id": "none", "name": "YWHAB dimer dissociates from KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10703880", "map_id": "none", "name": "p-S311 KSR1:MARK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725460", "map_id": "none", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703864", "map_id": "none", "name": "inactive RAFs:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725457", "map_id": "none", "name": "S-GCC MRAS:GTP:SHOC2:PP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O15757", "map_id": "O15757", "name": "pppB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275619", "map_id": "DDB_G0275619", "name": "pppB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HA8", "map_id": "Q54HA8", "name": "SHOC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289585", "map_id": "DDB_G0289585", "name": "SHOC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10704222", "map_id": "none", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10703915", "map_id": "none", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10704272", "map_id": "none", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10703862", "map_id": "none", "name": "inactive RAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10704268", "map_id": "none", "name": "Homologues of PAQR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54B86", "map_id": "Q54B86", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293838", "map_id": "DDB_G0293838", "name": "PAQR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FT1", "map_id": "Q54FT1", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CB4", "map_id": "Q54CB4", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10704270", "map_id": "none", "name": "PAQR3:inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10725637", "map_id": "none", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10725633", "map_id": "none", "name": "S-Farn-Me-2xPalmS HRAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10725631", "map_id": "none", "name": "RAL GDS proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725635", "map_id": "none", "name": "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10725306", "map_id": "none", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10678452", "map_id": "none", "name": "mature p21 RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703364", "map_id": "none", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703308", "map_id": "none", "name": "SPRED dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10703322", "map_id": "none", "name": "Homologues of NF1(2-2839)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725369", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10725367", "map_id": "none", "name": "Homologues of pS181-S-Farn-Me KRAS4B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10725313", "map_id": "none", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657579", "map_id": "none", "name": "RAF dimer inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725257", "map_id": "none", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10725253", "map_id": "none", "name": "S-Farn-Me PalmS KRAS4A,HRAS, NRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10725298", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10704082", "map_id": "none", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704079", "map_id": "none", "name": "RAS GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725281", "map_id": "none", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10725278", "map_id": "none", "name": "ZDHHC9:GOLGA7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54PF0", "map_id": "Q54PF0", "name": "ZDHHC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284603", "map_id": "DDB_G0284603", "name": "ZDHHC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557H5", "map_id": "Q557H5", "name": "ZDHHC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550I3", "map_id": "Q550I3", "name": "GOLGA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277093", "map_id": "DDB_G0277093", "name": "GOLGA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550R7", "map_id": "Q550R7", "name": "ZDHHC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703362", "map_id": "none", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10703326", "map_id": "none", "name": "RAS GAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Y08", "map_id": "Q54Y08", "name": "ngap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278483", "map_id": "DDB_G0278483", "name": "ngap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10703328", "map_id": "none", "name": "p21 RAS:GTP:RAS GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10704369", "map_id": "none", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10704367", "map_id": "none", "name": "p21RAS:GTP:p-S621 RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10704306", "map_id": "none", "name": "Homologues of hyperphosphorylated RAF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703360", "map_id": "none", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10703870", "map_id": "none", "name": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10703866", "map_id": "none", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10703331", "map_id": "none", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10725311", "map_id": "none", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10725308", "map_id": "none", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10676462", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676308", "map_id": "none", "name": "CCNT1,CCNT2,CCNK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10676297", "map_id": "Q556Z2", "name": "CDK9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10676310", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676470", "map_id": "none", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676446", "map_id": "none", "name": "Paused processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676448", "map_id": "none", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676452", "map_id": "none", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676450", "map_id": "none", "name": "Aborted elongation complex after arrest", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10674872", "map_id": "none", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674197", "map_id": "none", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109877", "map_id": "none", "name": "template DNA with first transcript dinucleotide, opened to +8 position", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10676460", "map_id": "none", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676365", "map_id": "Q54G78", "name": "ssrp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10676370", "map_id": "Q54S43", "name": "spt16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10676464", "map_id": "none", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676331", "map_id": "Q54NF2", "name": "spt4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10674956", "map_id": "none", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674954", "map_id": "none", "name": "pol II transcription complex containing 4-9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_75897", "map_id": "none", "name": "template DNA:4-9 nucleotide transcript hybrid", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10676468", "map_id": "none", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10676380", "map_id": "none", "name": "DSIF:NELF:early elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10676474", "map_id": "none", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10676476", "map_id": "none", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10674860", "map_id": "none", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10674858", "map_id": "none", "name": "Pol II Promoter Escape Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110068", "map_id": "none", "name": "DNA containing Pol II promoter with transcript with 2 or 3 nucleotides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10724807", "map_id": "none", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724800", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724804", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10724921", "map_id": "none", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724896", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724898", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724919", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54UN5", "map_id": "Q54UN5", "name": "NPRL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280947", "map_id": "DDB_G0280947", "name": "NPRL3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JS5", "map_id": "Q54JS5", "name": "wdr24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287817", "map_id": "DDB_G0287817", "name": "wdr24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551B5", "map_id": "Q551B5", "name": "mios", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276673", "map_id": "DDB_G0276673", "name": "mios", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BD9", "map_id": "Q55BD9", "name": "NPRL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271288", "map_id": "DDB_G0271288", "name": "NPRL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y15", "map_id": "Q54Y15", "name": "C12orf66", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278475", "map_id": "DDB_G0278475", "name": "C12orf66", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IH5", "map_id": "Q86IH5", "name": "SZT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272696", "map_id": "DDB_G0272696", "name": "SZT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K39", "map_id": "Q86K39", "name": "SEH1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277257", "map_id": "DDB_G0277257", "name": "SEH1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW3", "map_id": "Q54NW3", "name": "KPTN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284957", "map_id": "DDB_G0284957", "name": "KPTN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DE8", "map_id": "Q55DE8", "name": "ITFG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269680", "map_id": "DDB_G0269680", "name": "ITFG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS4", "map_id": "Q54DS4", "name": "WDR59", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292056", "map_id": "DDB_G0292056", "name": "WDR59", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA2", "map_id": "Q54XA2", "name": "DEPDC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279099", "map_id": "DDB_G0279099", "name": "DEPDC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724909", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724875", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:SESN1,2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724913", "map_id": "none", "name": "KICSTOR:GATOR1:BMT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724877", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10724997", "map_id": "none", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724894", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677442", "map_id": "none", "name": "RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10724995", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724887", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677461", "map_id": "none", "name": "mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724881", "map_id": "none", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724879", "map_id": "none", "name": "SESN1,2:L-Leu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724892", "map_id": "none", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724885", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10724889", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10724992", "map_id": "none", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10724990", "map_id": "none", "name": "FLCN:FNIP1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HT9", "map_id": "Q54HT9", "name": "FNIP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289243", "map_id": "DDB_G0289243", "name": "FNIP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UF2", "map_id": "Q54UF2", "name": "FLCN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281111", "map_id": "DDB_G0281111", "name": "FLCN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726077", "map_id": "none", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683360", "map_id": "none", "name": "IP3-gated Ca-channel type 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10683368", "map_id": "none", "name": "IP3-gated Ca-channel type 3 (open)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10726080", "map_id": "none", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_111875", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10702919", "map_id": "none", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702917", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q559B8", "map_id": "Q559B8", "name": "SPOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292428", "map_id": "DDB_G0292428", "name": "SPOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E93", "map_id": "Q55E93", "name": "bzpE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269338", "map_id": "DDB_G0269338", "name": "bzpE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D90", "map_id": "Q54D90", "name": "SPOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU7", "map_id": "Q54WU7", "name": "SPOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10702915", "map_id": "none", "name": "SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10702926", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10702923", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10687980", "map_id": "none", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687976", "map_id": "none", "name": "ISG15:UBEIL/UbcH8:CEB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10687978", "map_id": "none", "name": "ISG15:DDX58 conjugate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686695", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10686692", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54WT8", "map_id": "Q54WT8", "name": "aqpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279443", "map_id": "DDB_G0279443", "name": "aqpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686697", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10680301", "map_id": "none", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680289", "map_id": "none", "name": "p-T-AKT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10680298", "map_id": "none", "name": "PHLPP (Mn2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54AX5", "map_id": "Q54AX5", "name": "lrrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294094", "map_id": "DDB_G0294094", "name": "lrrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10680303", "map_id": "none", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10680166", "map_id": "Q556W3", "name": "THEM4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10718529", "map_id": "none", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10718524", "map_id": "none", "name": "LYZ:PGN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54XV8", "map_id": "Q54XV8", "name": "LYZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278563", "map_id": "DDB_G0278563", "name": "LYZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6789198", "map_id": "CHEBI:55424", "name": "GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6788991", "map_id": "none", "name": "MurNAc:Peptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:21615", "map_id": "CHEBI:21615", "name": "CHEBI:21615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788982", "map_id": "CHEBI:28009", "name": "betaGlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "reaction_10715120", "map_id": "none", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10715118", "map_id": "none", "name": "BPI:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10718526", "map_id": "none", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10712951", "map_id": "Q54XV8", "name": "LYZ", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10700306", "map_id": "none", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10700290", "map_id": "none", "name": "pT298-NLK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10700304", "map_id": "none", "name": "pT298-NLK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700369", "map_id": "none", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10700363", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10700367", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700238", "map_id": "none", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10700235", "map_id": "none", "name": "GNAT2:PDE6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702112", "map_id": "none", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5673778", "map_id": "CHEBI:16283", "name": "CySS-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_379444", "map_id": "CHEBI:16283", "name": "CySS-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702109", "map_id": "Q54WT7", "name": "ctns", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0279445", "map_id": "DDB_G0279445", "name": "ctns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684759", "map_id": "none", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10684756", "map_id": "none", "name": "SLC26A3,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684628", "map_id": "none", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_425969", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_425958", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10684625", "map_id": "Q54TB5", "name": "nhe2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0281877", "map_id": "DDB_G0281877", "name": "nhe2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722684", "map_id": "none", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722681", "map_id": "none", "name": "GLUT4 / SLC2A4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10720523", "map_id": "none", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720520", "map_id": "none", "name": "Homologues of SLC45A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10720514", "map_id": "none", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720511", "map_id": "Q551C0", "name": "SLC26A11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0276663", "map_id": "DDB_G0276663", "name": "SLC26A11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684806", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10684803", "map_id": "none", "name": "SLC17A6,7,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "true" }, { "id": "reaction_10684991", "map_id": "none", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429078", "map_id": "none", "name": "Fru,Glc,urate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429148", "map_id": "none", "name": "Fru,Glc,urate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684988", "map_id": "none", "name": "Homologues of SLC2A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684892", "map_id": "none", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684889", "map_id": "none", "name": "Homologues of SLC17A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722668", "map_id": "none", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722665", "map_id": "none", "name": "GLUT14 / SLC2A14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10684623", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684620", "map_id": "none", "name": "SLC9A1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q552S0", "map_id": "Q552S0", "name": "nhe1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275711", "map_id": "DDB_G0275711", "name": "nhe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TB5", "map_id": "Q54TB5", "name": "nhe2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685930", "map_id": "none", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10679311", "map_id": "none", "name": "GLUT2 / SLC2A2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10722673", "map_id": "none", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10722670", "map_id": "none", "name": "GLUT3 / SLC2A3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702091", "map_id": "none", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685921", "map_id": "none", "name": "GLUT1 / SLC2A1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10720498", "map_id": "none", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720493", "map_id": "Q86AV5", "name": "mcfX", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0276933", "map_id": "DDB_G0276933", "name": "mcfX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685010", "map_id": "none", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10685007", "map_id": "none", "name": "SLC2A6,8,10,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54M69", "map_id": "Q54M69", "name": "SLC2A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286151", "map_id": "DDB_G0286151", "name": "SLC2A6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10722686", "map_id": "none", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10720653", "map_id": "none", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10720650", "map_id": "Q54JW5", "name": "slc50a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0287763", "map_id": "DDB_G0287763", "name": "slc50a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10684972", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10684969", "map_id": "none", "name": "GLUT7/11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685927", "map_id": "none", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685923", "map_id": "none", "name": "GLUT1:ATP tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10702698", "map_id": "none", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702695", "map_id": "none", "name": "Homologues of SLC26A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10685925", "map_id": "none", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10684742", "map_id": "none", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10684739", "map_id": "none", "name": "SLC26 chloride transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10715026", "map_id": "none", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10715020", "map_id": "none", "name": "Homologues of PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10715023", "map_id": "none", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10715006", "map_id": "none", "name": "Homologues of MonoUb-K13,K289-PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698755", "map_id": "Q869U4", "name": "USP7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10721791", "map_id": "none", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721783", "map_id": "Q54Y76", "name": "maf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278673", "map_id": "DDB_G0278673", "name": "phospho-maf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721788", "map_id": "Q54Y76", "name": "phospho-maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10717104", "map_id": "none", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717102", "map_id": "none", "name": "Homologues of p-3S,2T-PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10715008", "map_id": "none", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10714984", "map_id": "none", "name": "Homologues of MonoUb-K13,K289-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721861", "map_id": "none", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10721849", "map_id": "none", "name": "Homologues of RibC-E40,E150,D326-PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10721858", "map_id": "none", "name": "TNKS1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86J21", "map_id": "Q86J21", "name": "TNKS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274293", "map_id": "DDB_G0274293", "name": "TNKS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10721834", "map_id": "none", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689058", "map_id": "Q54TM9", "name": "MKRN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10721832", "map_id": "Q54TM9", "name": "phospho-p-S109-MKRN1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10721837", "map_id": "none", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715071", "map_id": "none", "name": "Homologues of K48polyUb-K289-PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10715083", "map_id": "none", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715073", "map_id": "none", "name": "PolyUb-PTEN,K48polyUb-K289-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715080", "map_id": "none", "name": "USP13,OTUD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FY4", "map_id": "Q55FY4", "name": "OTUD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10717150", "map_id": "none", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10717148", "map_id": "none", "name": "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10721793", "map_id": "none", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10721781", "map_id": "Q54Y76", "name": "maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10715054", "map_id": "none", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10715043", "map_id": "none", "name": "Homologues of PolyUb-PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10715051", "map_id": "none", "name": "NEDD4,STUB1,WWP2 and XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686632", "map_id": "none", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686100", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MG5", "map_id": "Q54MG5", "name": "phospho-p-S60,S186-ZFP36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285973", "map_id": "DDB_G0285973", "name": "phospho-p-S60,S186-ZFP36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686630", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686107", "map_id": "none", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686094", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686046", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686113", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686092", "map_id": "Q54MG5", "name": "ZFP36L1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10686104", "map_id": "none", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685103", "map_id": "Q54KM1", "name": "DCP1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287243", "map_id": "DDB_G0287243", "name": "DCP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686055", "map_id": "Q54GU2", "name": "XRN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0289921", "map_id": "DDB_G0289921", "name": "XRN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685110", "map_id": "Q54R87", "name": "dcp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283315", "map_id": "DDB_G0283315", "name": "dcp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685181", "map_id": "none", "name": "Exosome Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10686102", "map_id": "none", "name": "BRF1:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GU2", "map_id": "Q54GU2", "name": "XRN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R87", "map_id": "Q54R87", "name": "dcp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KM1", "map_id": "Q54KM1", "name": "DCP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10686050", "map_id": "none", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686048", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10679303", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10679300", "map_id": "none", "name": "Homologues of SLC2A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10679314", "map_id": "none", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189246", "map_id": "none", "name": "Fru, Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_189219", "map_id": "none", "name": "Fru, Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10725864", "map_id": "none", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701655", "map_id": "none", "name": "(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725862", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10725860", "map_id": "none", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701649", "map_id": "none", "name": "(RIPK1:RIPK3)oligomer:4xMLKL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10725858", "map_id": "none", "name": "(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10709720", "map_id": "none", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692450", "map_id": "CHEBI:36916", "name": "cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692484", "map_id": "CHEBI:36916", "name": "cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10709717", "map_id": "none", "name": "Homologues of ATP13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54X63", "map_id": "Q54X63", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284955", "map_id": "DDB_G0284955", "name": "ATP13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P22", "map_id": "Q54P22", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW5", "map_id": "Q54NW5", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687988", "map_id": "none", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10687985", "map_id": "Q54Q77", "name": "ATP7B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0284141", "map_id": "DDB_G0284141", "name": "ATP7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10688162", "map_id": "none", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_10688101", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54L55", "map_id": "Q54L55", "name": "ATP10D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286891", "map_id": "DDB_G0286891", "name": "ATP10D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553A4", "map_id": "Q553A4", "name": "ATP11C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281401", "map_id": "DDB_G0281401", "name": "ATP11C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E09", "map_id": "Q55E09", "name": "ATP9A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270870", "map_id": "DDB_G0270870", "name": "ATP9A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U08", "map_id": "Q54U08", "name": "ATP11C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H52", "map_id": "Q86H52", "name": "ATP11C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551T0", "map_id": "Q551T0", "name": "ATP11C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E61", "map_id": "Q55E61", "name": "ATP10D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701952", "map_id": "none", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5252122", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5252016", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10701949", "map_id": "none", "name": "ATP13A4, 5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10709709", "map_id": "none", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1981162", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10709706", "map_id": "Q54CD1", "name": "ctaA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293004", "map_id": "DDB_G0293004", "name": "ctaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10696020", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10696017", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10702333", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702330", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10710970", "map_id": "none", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10710940", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10710968", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane", "complex": "true" }, { "id": "reaction_10716374", "map_id": "none", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10716371", "map_id": "Q54QI3", "name": "NCEH1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10720699", "map_id": "none", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10720695", "map_id": "Q9TVK6", "name": "npcA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0269158", "map_id": "DDB_G0269158", "name": "npcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10720691", "map_id": "none", "name": "NPC2:CHOL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54SW2", "map_id": "Q54SW2", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287185", "map_id": "DDB_G0287185", "name": "NPC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BL4", "map_id": "Q55BL4", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SZ8", "map_id": "Q54SZ8", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SW1", "map_id": "Q54SW1", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV4", "map_id": "Q54MV4", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TL9", "map_id": "Q54TL9", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SZ9", "map_id": "Q54SZ9", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YD2", "map_id": "Q54YD2", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KP7", "map_id": "Q54KP7", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10720689", "map_id": "none", "name": "Homologues of NPC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10720697", "map_id": "none", "name": "NPC1:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q9TVK6", "map_id": "Q9TVK6", "name": "npcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10710972", "map_id": "none", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10710966", "map_id": "none", "name": "Clathrin:AP2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10720693", "map_id": "none", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10720701", "map_id": "none", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10705109", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10705051", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10705071", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10718240", "map_id": "none", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10718230", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10718238", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10718758", "map_id": "none", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10718738", "map_id": "none", "name": "Homologues of OPA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10718750", "map_id": "none", "name": "Homologues of OPA1(88-194)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10718744", "map_id": "none", "name": "Homologues of OPA1(195-960)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10718755", "map_id": "Q54HN7", "name": "OMA1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0289335", "map_id": "DDB_G0289335", "name": "OMA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10677317", "map_id": "none", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10677313", "map_id": "none", "name": "POLRMT:TFB2M complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54M56", "map_id": "Q54M56", "name": "TFB2M", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286199", "map_id": "DDB_G0286199", "name": "TFB2M", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95NZ8", "map_id": "Q95NZ8", "name": "rpmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267416", "map_id": "DDB_G0267416", "name": "rpmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677301", "map_id": "none", "name": "TFAM:mitochondrial promoter complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10677315", "map_id": "none", "name": "POLRMT:TFB2M:TFAM:mitochondrial promoter complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10677319", "map_id": "none", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_163305", "map_id": "none", "name": "mitochondrial DNA promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10677299", "map_id": "Q55C24", "name": "nhp6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10701526", "map_id": "none", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701518", "map_id": "none", "name": "p-S-RIPK1:RIPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10698937", "map_id": "none", "name": "p-S166-RIPK1:p-S199,227-RIPK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701516", "map_id": "none", "name": "RIPK1:RIPK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701521", "map_id": "none", "name": "RIPK1:RIPK3:sorafenib, ponatinib, pazopanib", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "LigandDisplayForward?ligandId=5711", "map_id": "LigandDisplayForward?ligandId=5711", "name": "LigandDisplayForward?ligandId=5711", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5698", "map_id": "LigandDisplayForward?ligandId=5698", "name": "LigandDisplayForward?ligandId=5698", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LigandDisplayForward?ligandId=5890", "map_id": "LigandDisplayForward?ligandId=5890", "name": "LigandDisplayForward?ligandId=5890", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701523", "map_id": "none", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10701651", "map_id": "none", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10698939", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701647", "map_id": "none", "name": "Homologues of MLKL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10702537", "map_id": "none", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5620974", "map_id": "none", "name": "PI4P,PI(4,5)P2,PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702526", "map_id": "none", "name": "RIP1:RIP3:MLKL oligomer:PIPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10702535", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T7K0", "map_id": "Q8T7K0", "name": "alxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275451", "map_id": "DDB_G0275451", "name": "alxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701658", "map_id": "none", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10701653", "map_id": "none", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10697256", "map_id": "none", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10724239", "map_id": "none", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10724169", "map_id": "Q54XC3", "name": "TYSND1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0279049", "map_id": "DDB_G0279049", "name": "TYSND1(111-566)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724234", "map_id": "Q54XC3", "name": "TYSND1(1-110)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10724236", "map_id": "Q54XC3", "name": "TYSND1(111-566)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10683109", "map_id": "none", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680440", "map_id": "none", "name": "p-AMPK heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10683111", "map_id": "none", "name": "LKB1 forms a trimeric complex with STRAD and MO25", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680445", "map_id": "Q55CW1", "name": "samkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10680470", "map_id": "none", "name": "STRAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q551H4", "map_id": "Q551H4", "name": "fray2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276577", "map_id": "DDB_G0276577", "name": "fray2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XL6", "map_id": "Q54XL6", "name": "fray1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278863", "map_id": "DDB_G0278863", "name": "fray1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680454", "map_id": "none", "name": "MO25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C7G028", "map_id": "C7G028", "name": "CAB39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284307", "map_id": "DDB_G0284307", "name": "CAB39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10680472", "map_id": "none", "name": "LKB1:STRAD:MO25", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10680475", "map_id": "none", "name": "Activation of cytosolic AMPK by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10680420", "map_id": "none", "name": "AMPK heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685835", "map_id": "none", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10703641", "map_id": "none", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677539", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-T246-AKT1S1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677541", "map_id": "none", "name": "mTORC1:p-T246-AKT1S1:YWHAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10677561", "map_id": "none", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677534", "map_id": "none", "name": "eIF4E:4E-BP1-P", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677559", "map_id": "none", "name": "FKBP1A:sirolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9678687", "map_id": "LigandDisplayForward?ligandId=6031", "name": "sirolimus", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677545", "map_id": "none", "name": "mTORC1:RHEB:GTP:AKT1S1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10702256", "map_id": "none", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702253", "map_id": "none", "name": "ALDH1A1,2,3 tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677608", "map_id": "none", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677603", "map_id": "Q54SF9", "name": "mhkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282489", "map_id": "DDB_G0282489", "name": "phospho-mhkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677606", "map_id": "Q54SF9", "name": "phospho-mhkD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677575", "map_id": "P34102", "name": "phospho-pkgC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10682921", "map_id": "none", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10680774", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10703164", "map_id": "none", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677522", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677524", "map_id": "none", "name": "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10702550", "map_id": "none", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_5623648", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623650", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10702547", "map_id": "Q54I93", "name": "RDH13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0288917", "map_id": "DDB_G0288917", "name": "RDH13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10726000", "map_id": "none", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1254400", "map_id": "CHEBI:50114", "name": "ESTG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10721488", "map_id": "none", "name": "ESR2:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54WQ9", "map_id": "Q54WQ9", "name": "PPID", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279491", "map_id": "DDB_G0279491", "name": "PPID", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FM3", "map_id": "Q55FM3", "name": "PTGES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RH6", "map_id": "Q54RH6", "name": "PPP5C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10721490", "map_id": "none", "name": "ESTG:ESR2:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10677587", "map_id": "none", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677571", "map_id": "P34102", "name": "pkgC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10677598", "map_id": "none", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10673172", "map_id": "Q54UU3", "name": "rps6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10677595", "map_id": "Q54UU3", "name": "phospho-rps6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10702269", "map_id": "none", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10702266", "map_id": "Q54BI7", "name": "RDH14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293604", "map_id": "DDB_G0293604", "name": "RDH14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10703166", "map_id": "none", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677518", "map_id": "none", "name": "RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677490", "map_id": "none", "name": "Ragulator", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10677520", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10710352", "map_id": "none", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5362565", "map_id": "CHEBI:78273", "name": "9cRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5362520", "map_id": "CHEBI:50648", "name": "9cRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10710349", "map_id": "Q54QC5", "name": "ALDH8A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283943", "map_id": "DDB_G0283943", "name": "ALDH8A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702261", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702258", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10703160", "map_id": "none", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677478", "map_id": "Q86J23", "name": "LAMTOR3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10677473", "map_id": "Q54F59", "name": "mapbpip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10677488", "map_id": "Q54QW5", "name": "LAMTOR5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10677468", "map_id": "Q1ZXA8", "name": "LAMTOR1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10677483", "map_id": "Q54DY3", "name": "LAMTOR4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10703650", "map_id": "none", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10703647", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10677566", "map_id": "none", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677532", "map_id": "Q54DU8", "name": "phospho-febA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10697038", "map_id": "none", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10697036", "map_id": "none", "name": "PDPK1:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10721494", "map_id": "none", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10721482", "map_id": "none", "name": "ESR1:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10721484", "map_id": "none", "name": "ESTG:ESR1:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10677528", "map_id": "none", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10692083", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10692076", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10692080", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10722291", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10725838", "map_id": "none", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10698857", "map_id": "none", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10698851", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q54C24", "map_id": "Q54C24", "name": "vps35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293218", "map_id": "DDB_G0293218", "name": "vps35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IF7", "map_id": "Q54IF7", "name": "vps29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288787", "map_id": "DDB_G0288787", "name": "vps29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA0", "map_id": "Q55CA0", "name": "vps26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269168", "map_id": "DDB_G0269168", "name": "vps26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10698855", "map_id": "none", "name": "WLS:retromer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10723074", "map_id": "none", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10723069", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10723071", "map_id": "none", "name": "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10703162", "map_id": "none", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677503", "map_id": "none", "name": "RRAGA, RRAGB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677516", "map_id": "none", "name": "RRAGC,RRAGD:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10677615", "map_id": "none", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677613", "map_id": "Q553R3", "name": "phospho-eif4g", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10677444", "map_id": "none", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10677440", "map_id": "none", "name": "RHEB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10692085", "map_id": "none", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10692072", "map_id": "none", "name": "CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689651", "map_id": "none", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689645", "map_id": "none", "name": "DOCK-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689647", "map_id": "none", "name": "RAC1, CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689649", "map_id": "none", "name": "DOCK-GEFs:RAC1, CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10689421", "map_id": "none", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689367", "map_id": "Q6RZZ9", "name": "kif13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288361", "map_id": "DDB_G0288361", "name": "kif13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689369", "map_id": "none", "name": "Kinesin-5 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6RZZ9", "map_id": "Q6RZZ9", "name": "kif13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10689432", "map_id": "none", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10689428", "map_id": "O15819", "name": "H3a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10689425", "map_id": "Q54RN0", "name": "CBX5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10689430", "map_id": "none", "name": "HP1alpha:Histone H3 methylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697214", "map_id": "none", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689437", "map_id": "Q55D87", "name": "ITPK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10689440", "map_id": "none", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10689423", "map_id": "none", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10689374", "map_id": "Q54NP8", "name": "kif4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285101", "map_id": "DDB_G0285101", "name": "kif4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689376", "map_id": "none", "name": "CENP-E dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NP8", "map_id": "Q54NP8", "name": "kif4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10689514", "map_id": "none", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10689511", "map_id": "Q54CT8", "name": "adkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10684256", "map_id": "none", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10676753", "map_id": "none", "name": "P2RX receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_114570", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10689443", "map_id": "none", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10689499", "map_id": "none", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687040", "map_id": "none", "name": "F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10689495", "map_id": "none", "name": "Homologues of LRRC16A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NS2", "map_id": "Q54NS2", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293920", "map_id": "DDB_G0293920", "name": "LRRC16A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B76", "map_id": "Q54B76", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B43", "map_id": "Q54B43", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YK2", "map_id": "Q54YK2", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G18", "map_id": "Q54G18", "name": "gacW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290439", "map_id": "DDB_G0290439", "name": "gacW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LE3", "map_id": "Q54LE3", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SR9", "map_id": "Q54SR9", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWW4", "map_id": "Q7KWW4", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95VZ3", "map_id": "Q95VZ3", "name": "carmil", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292386", "map_id": "DDB_G0292386", "name": "carmil", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MF0", "map_id": "Q54MF0", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10689497", "map_id": "none", "name": "LRRC16A:F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10687042", "map_id": "none", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687038", "map_id": "P13021", "name": "acpA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687033", "map_id": "P13022", "name": "acpB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10680829", "map_id": "none", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202277", "map_id": "none", "name": "PIP3, PI(3,4)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10680827", "map_id": "none", "name": "PDK1:PIP2,PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10724241", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724179", "map_id": "none", "name": "PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54WA3", "map_id": "Q54WA3", "name": "pex7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279801", "map_id": "DDB_G0279801", "name": "pex7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724181", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10724072", "map_id": "none", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724057", "map_id": "Q54WA3", "name": "pex7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10724068", "map_id": "none", "name": "Cargo proteins containing PTS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96759", "map_id": "O96759", "name": "eapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286183", "map_id": "DDB_G0286183", "name": "eapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IY4", "map_id": "Q86IY4", "name": "ACAA1(1-424)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724070", "map_id": "none", "name": "PEX7:Cargo proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724186", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724183", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10724348", "map_id": "none", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724328", "map_id": "none", "name": "PEX3:PEX19:class I PMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q55FL0", "map_id": "Q55FL0", "name": "PXMP4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268564", "map_id": "DDB_G0268564", "name": "PXMP4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXK7", "map_id": "Q1ZXK7", "name": "ATAD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276169", "map_id": "DDB_G0276169", "name": "ATAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZX5", "map_id": "Q54ZX5", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277335", "map_id": "DDB_G0277335", "name": "PXMP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550G0", "map_id": "Q550G0", "name": "pex16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277113", "map_id": "DDB_G0277113", "name": "pex16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H86", "map_id": "Q54H86", "name": "pex11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289623", "map_id": "DDB_G0289623", "name": "pex11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX0", "map_id": "Q54VX0", "name": "FIS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280367", "map_id": "DDB_G0280367", "name": "FIS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AC7", "map_id": "Q86AC7", "name": "PEX11B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276913", "map_id": "DDB_G0276913", "name": "PEX11B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76P23", "map_id": "Q76P23", "name": "mcfQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U86", "map_id": "Q54U86", "name": "pex3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724346", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10724616", "map_id": "none", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724470", "map_id": "none", "name": "SGTA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VG4", "map_id": "Q54VG4", "name": "sgt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280345", "map_id": "DDB_G0280345", "name": "sgt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724612", "map_id": "none", "name": "Mislocalized membrane protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724614", "map_id": "none", "name": "Mislocalized membrane protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724509", "map_id": "none", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724505", "map_id": "none", "name": "Tail-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XS7", "map_id": "Q54XS7", "name": "VAPA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278773", "map_id": "DDB_G0278773", "name": "VAPA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JV6", "map_id": "Q54JV6", "name": "sec61g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287777", "map_id": "DDB_G0287777", "name": "sec61g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553P6", "map_id": "Q553P6", "name": "serp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275381", "map_id": "DDB_G0275381", "name": "serp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YR4", "map_id": "Q54YR4", "name": "sec61b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278117", "map_id": "DDB_G0278117", "name": "sec61b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724507", "map_id": "none", "name": "Tail-anchored protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724173", "map_id": "none", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724151", "map_id": "none", "name": "PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q7KWR0", "map_id": "Q7KWR0", "name": "NUDT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276281", "map_id": "DDB_G0276281", "name": "NUDT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XC3", "map_id": "Q54XC3", "name": "TYSND1(111-566)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GK8", "map_id": "Q54GK8", "name": "MLYCD(40-493)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC2", "map_id": "Q54GC2", "name": "NUDT19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54US8", "map_id": "Q54US8", "name": "PIPOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XX9", "map_id": "Q54XX9", "name": "MPV17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278529", "map_id": "DDB_G0278529", "name": "MPV17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JQ2", "map_id": "Q54JQ2", "name": "IDE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287851", "map_id": "DDB_G0287851", "name": "IDE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SS0", "map_id": "Q54SS0", "name": "ech1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282261", "map_id": "DDB_G0282261", "name": "ech1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10724171", "map_id": "none", "name": "Cargo proteins containing PTS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10724195", "map_id": "none", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724192", "map_id": "none", "name": "USP9X:Ub:PEX5L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10717909", "map_id": "none", "name": "Homologues of USP9X", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724232", "map_id": "none", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724222", "map_id": "none", "name": "PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10724230", "map_id": "none", "name": "Cargo proteins containing PTS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10724352", "map_id": "none", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724324", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724326", "map_id": "none", "name": "PEX19:class I PMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724218", "map_id": "none", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10724190", "map_id": "none", "name": "Ub:PEX5L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10724175", "map_id": "none", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10724147", "map_id": "none", "name": "PEX5S,L:Cargo protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10724149", "map_id": "none", "name": "PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10724350", "map_id": "none", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10701703", "map_id": "none", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701699", "map_id": "Q54WT5", "name": "DMTN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279449", "map_id": "DDB_G0279449", "name": "DMTN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701694", "map_id": "none", "name": "ADD1:ADD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T47", "map_id": "Q54T47", "name": "ADD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282009", "map_id": "DDB_G0282009", "name": "ADD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10701701", "map_id": "none", "name": "ADD1:ADD2:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WT5", "map_id": "Q54WT5", "name": "DMTN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702088", "map_id": "none", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702085", "map_id": "Q553K8", "name": "MRS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0275813", "map_id": "DDB_G0275813", "name": "MRS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702104", "map_id": "none", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_114632", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10702101", "map_id": "Q54N33", "name": "ost3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285537", "map_id": "DDB_G0285537", "name": "ost3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10702099", "map_id": "none", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10702096", "map_id": "Q54N33", "name": "ost3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10721599", "map_id": "none", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8941540", "map_id": "none", "name": "I-, Cl-", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8941541", "map_id": "none", "name": "I-, Cl-", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10721596", "map_id": "none", "name": "VRAC heteromer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10701711", "map_id": "none", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10701707", "map_id": "none", "name": "ADD1:ADD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701709", "map_id": "none", "name": "ADD1:ADD3:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10675618", "map_id": "none", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113571", "map_id": "CHEBI:37565", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10675608", "map_id": "none", "name": "Capping complex (hydrolyzed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675615", "map_id": "none", "name": "Capping complex (intermediate)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675632", "map_id": "none", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675625", "map_id": "none", "name": "Capping complex (with freed 5'- GMP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10672159", "map_id": "none", "name": "RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675629", "map_id": "none", "name": "mRNA capping factors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675623", "map_id": "none", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675620", "map_id": "none", "name": "Capping complex (GpppN..)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675606", "map_id": "none", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_72084", "map_id": "none", "name": "nascent pre-mRNA transcript", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10675604", "map_id": "none", "name": "Capping complex (initial)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675634", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672073", "map_id": "Q54KR9", "name": "ncbp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672078", "map_id": "Q55D17", "name": "ncbp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672080", "map_id": "none", "name": "Cap Binding Complex (CBC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675611", "map_id": "none", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10675627", "map_id": "none", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10675636", "map_id": "none", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10711945", "map_id": "none", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10711942", "map_id": "none", "name": "Shortened telomere:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10704963", "map_id": "none", "name": "Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10722637", "map_id": "none", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698776", "map_id": "O77033", "name": "trfA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10698778", "map_id": "none", "name": "KDM6B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O77033", "map_id": "O77033", "name": "trfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10698781", "map_id": "none", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10698769", "map_id": "none", "name": "CDKN2A Gene:H3K27Me3-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10698771", "map_id": "none", "name": "CDKN2A Gene:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10704968", "map_id": "none", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10704965", "map_id": "none", "name": "Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10718247", "map_id": "none", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855492", "map_id": "CHEBI:18022", "name": "SCN(-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855489", "map_id": "CHEBI:133907", "name": "OSCN-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10718244", "map_id": "none", "name": "LPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:55376", "map_id": "CHEBI:55376", "name": "CHEBI:55376", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10712967", "map_id": "none", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen" }, { "id": "species_10712871", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen", "complex": "true" }, { "id": "Q65YR8", "map_id": "Q65YR8", "name": "cpiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291834", "map_id": "DDB_G0291834", "name": "cpiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RX2", "map_id": "Q54RX2", "name": "CNN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282859", "map_id": "DDB_G0282859", "name": "CNN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FR5", "map_id": "Q55FR5", "name": "ypel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267990", "map_id": "DDB_G0267990", "name": "ypel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FS4", "map_id": "Q55FS4", "name": "CNN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JM9", "map_id": "Q54JM9", "name": "nit2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287939", "map_id": "DDB_G0287939", "name": "nit2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B14", "map_id": "Q54B14", "name": "qpct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293986", "map_id": "DDB_G0293986", "name": "qpct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL4", "map_id": "Q54HL4", "name": "gghB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289365", "map_id": "DDB_G0289365", "name": "gghB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5R1U3", "map_id": "Q5R1U3", "name": "cpiC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277001", "map_id": "DDB_G0277001", "name": "cpiC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D97", "map_id": "Q55D97", "name": "armc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270626", "map_id": "DDB_G0270626", "name": "armc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q65YR7", "map_id": "Q65YR7", "name": "cpiB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280439", "map_id": "DDB_G0280439", "name": "cpiB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GV9", "map_id": "Q55GV9", "name": "ChLim", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267490", "map_id": "DDB_G0267490", "name": "ChLim", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712965", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10711257", "map_id": "none", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_6788973", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222719", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6789150", "map_id": "CHEBI:24757", "name": "HOCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222475", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10711254", "map_id": "none", "name": "MPO:ferriheme:bacterial cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10714086", "map_id": "none", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen" }, { "id": "species_10713952", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen", "complex": "true" }, { "id": "B0G108", "map_id": "B0G108", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289251", "map_id": "DDB_G0289251", "name": "PLAC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FU1", "map_id": "Q55FU1", "name": "TXNDC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267952", "map_id": "DDB_G0267952", "name": "TXNDC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CG6", "map_id": "Q55CG6", "name": "UNC13D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279583", "map_id": "DDB_G0279583", "name": "UNC13D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554H6", "map_id": "Q554H6", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VE2", "map_id": "Q54VE2", "name": "FAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291259", "map_id": "DDB_G0291259", "name": "FAF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F06", "map_id": "Q55F06", "name": "UNC13D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EZ0", "map_id": "Q54EZ0", "name": "FAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A73", "map_id": "Q86A73", "name": "FAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H23", "map_id": "Q54H23", "name": "PRCP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289749", "map_id": "DDB_G0289749", "name": "PRCP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P50", "map_id": "Q54P50", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HT4", "map_id": "Q54HT4", "name": "DPP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289231", "map_id": "DDB_G0289231", "name": "DPP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG4", "map_id": "Q1ZXG4", "name": "prlA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282361", "map_id": "DDB_G0282361", "name": "prlA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7FZY2", "map_id": "C7FZY2", "name": "RNASET2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295845", "map_id": "DDB_G0295845", "name": "RNASET2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GE1", "map_id": "Q54GE1", "name": "glb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WK5", "map_id": "Q54WK5", "name": "UNC13D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HS6", "map_id": "Q54HS6", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JY8", "map_id": "Q54JY8", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54654", "map_id": "P54654", "name": "cap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288769", "map_id": "DDB_G0288769", "name": "cap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714084", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10714758", "map_id": "none", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10714736", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800405", "compartment_display": "ficolin-1-rich granule lumen", "complex": "true" }, { "id": "O96923", "map_id": "O96923", "name": "gnrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291125", "map_id": "DDB_G0291125", "name": "gnrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34118", "map_id": "P34118", "name": "mvpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269156", "map_id": "DDB_G0269156", "name": "mvpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG1", "map_id": "Q54PG1", "name": "dlcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284589", "map_id": "DDB_G0284589", "name": "dlcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EF8", "map_id": "Q54EF8", "name": "GSN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291536", "map_id": "DDB_G0291536", "name": "GSN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10733", "map_id": "P10733", "name": "sevA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289327", "map_id": "DDB_G0289327", "name": "sevA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S93", "map_id": "Q54S93", "name": "gmfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282595", "map_id": "DDB_G0282595", "name": "gmfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA9", "map_id": "Q55GA9", "name": "APEH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXP5", "map_id": "Q1ZXP5", "name": "vilC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271058", "map_id": "DDB_G0271058", "name": "vilC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S11", "map_id": "Q54S11", "name": "GSN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QS2", "map_id": "Q54QS2", "name": "PPIA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283663", "map_id": "DDB_G0283663", "name": "PPIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SM3", "map_id": "Q54SM3", "name": "ppiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282359", "map_id": "DDB_G0282359", "name": "ppiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551I6", "map_id": "Q551I6", "name": "GSN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G198", "map_id": "B0G198", "name": "COTL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295683", "map_id": "DDB_G0295683", "name": "COTL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QS3", "map_id": "Q54QS3", "name": "ddx3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283661", "map_id": "DDB_G0283661", "name": "ddx3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MUF9", "map_id": "Q8MUF9", "name": "cplA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269200", "map_id": "DDB_G0269200", "name": "cplA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556U5", "map_id": "Q556U5", "name": "PDAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273095", "map_id": "DDB_G0273095", "name": "PDAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36418", "map_id": "P36418", "name": "vilB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276453", "map_id": "DDB_G0276453", "name": "vilB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K94", "map_id": "Q54K94", "name": "AGL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UA41", "map_id": "Q9UA41", "name": "cypD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280401", "map_id": "DDB_G0280401", "name": "cypD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WQ85", "map_id": "Q8WQ85", "name": "vilA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288557", "map_id": "DDB_G0288557", "name": "vilA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714756", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10712473", "map_id": "none", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6798757", "compartment_display": "azurophil granule membrane" }, { "id": "species_10712371", "map_id": "none", "name": "Azurophil granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6798757", "compartment_display": "azurophil granule membrane", "complex": "true" }, { "id": "Q54R04", "map_id": "Q54R04", "name": "arl8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283525", "map_id": "DDB_G0283525", "name": "arl8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P72", "map_id": "Q54P72", "name": "ACPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P71", "map_id": "Q54P71", "name": "ACPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET2", "map_id": "Q54ET2", "name": "psenA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291352", "map_id": "DDB_G0291352", "name": "psenA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N33", "map_id": "Q54N33", "name": "ost3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JT7", "map_id": "Q54JT7", "name": "ncstn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287801", "map_id": "DDB_G0287801", "name": "ncstn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552S3", "map_id": "Q552S3", "name": "MANBA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551J1", "map_id": "Q551J1", "name": "TMEM30A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276567", "map_id": "DDB_G0276567", "name": "TMEM30A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E62", "map_id": "Q54E62", "name": "ddost", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291780", "map_id": "DDB_G0291780", "name": "ddost", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PR9", "map_id": "Q54PR9", "name": "cf60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284363", "map_id": "DDB_G0284363", "name": "cf60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DE8", "map_id": "Q54DE8", "name": "psenB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292310", "map_id": "DDB_G0292310", "name": "psenB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LZ3", "map_id": "Q54LZ3", "name": "DNAJC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286293", "map_id": "DDB_G0286293", "name": "DNAJC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10712471", "map_id": "none", "name": "Azurophil granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10686832", "map_id": "none", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677800", "map_id": "none", "name": "NOD1:iE-DAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_622271", "map_id": "CHEBI:59271", "name": "iE-DAP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55BX4", "map_id": "Q55BX4", "name": "NOD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280575", "map_id": "DDB_G0280575", "name": "NOD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WP6", "map_id": "Q54WP6", "name": "NOD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V73", "map_id": "Q54V73", "name": "NOD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14195", "map_id": "P14195", "name": "AAC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291860", "map_id": "DDB_G0291860", "name": "AAC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10677804", "map_id": "none", "name": "NOD1:iE-DAP oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686854", "map_id": "none", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677816", "map_id": "none", "name": "MDP:NOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_708341", "map_id": "CHEBI:59414", "name": "MDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10677818", "map_id": "none", "name": "MDP:NOD2 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10711262", "map_id": "none", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10711252", "map_id": "none", "name": "MPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10721333", "map_id": "none", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_6789221", "map_id": "CHEBI:16301", "name": "nitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_8933637", "map_id": "CHEBI:33101", "name": "NO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10677802", "map_id": "none", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677798", "map_id": "none", "name": "Homologues of NOD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10713614", "map_id": "none", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_10713428", "map_id": "none", "name": "Secretory granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "species_10713612", "map_id": "none", "name": "Secretory granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10711260", "map_id": "none", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "reaction_10677848", "map_id": "none", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677814", "map_id": "none", "name": "Homologues of NOD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10713716", "map_id": "none", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799371", "compartment_display": "specific granule lumen" }, { "id": "species_10713682", "map_id": "none", "name": "Specific granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799371", "compartment_display": "specific granule lumen", "complex": "true" }, { "id": "species_10713714", "map_id": "none", "name": "Specific granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10714477", "map_id": "none", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane" }, { "id": "species_10714461", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane", "complex": "true" }, { "id": "Q55E78", "map_id": "Q55E78", "name": "TBC1D10A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275421", "map_id": "DDB_G0275421", "name": "TBC1D10A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553U1", "map_id": "Q553U1", "name": "TBC1D10A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U95", "map_id": "Q54U95", "name": "ATP6AP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281325", "map_id": "DDB_G0281325", "name": "ATP6AP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557H3", "map_id": "Q557H3", "name": "C16orf62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273473", "map_id": "DDB_G0273473", "name": "C16orf62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869V1", "map_id": "Q869V1", "name": "nramp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714475", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10689989", "map_id": "none", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_10689986", "map_id": "none", "name": "V-ATPase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10725834", "map_id": "none", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10725772", "map_id": "Q55E90", "name": "AAMP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269344", "map_id": "DDB_G0269344", "name": "AAMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10725832", "map_id": "none", "name": "AAMP:NOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55E90", "map_id": "Q55E90", "name": "AAMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10714292", "map_id": "none", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane" }, { "id": "species_10714270", "map_id": "none", "name": "Specific granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane", "complex": "true" }, { "id": "Q54S39", "map_id": "Q54S39", "name": "PGRMC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282683", "map_id": "DDB_G0282683", "name": "PGRMC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GC2", "map_id": "Q55GC2", "name": "dst2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267730", "map_id": "DDB_G0267730", "name": "dst2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02465", "map_id": "Q02465", "name": "spiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289075", "map_id": "DDB_G0289075", "name": "spiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D94", "map_id": "Q55D94", "name": "DEGS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34138", "map_id": "P34138", "name": "ptpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277865", "map_id": "DDB_G0277865", "name": "ptpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10714290", "map_id": "none", "name": "Specific granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10677846", "map_id": "none", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10677842", "map_id": "none", "name": "Homologues of RIPK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677820", "map_id": "none", "name": "PAMP:NOD oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10677844", "map_id": "none", "name": "PAMP:NOD oligomer:RIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10712733", "map_id": "none", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10712651", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10712731", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10713133", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10713083", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "species_10713131", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10686034", "map_id": "none", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686030", "map_id": "none", "name": "Phosphorylated TTP:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CQ7", "map_id": "Q55CQ7", "name": "tnpo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269948", "map_id": "DDB_G0269948", "name": "tnpo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10686032", "map_id": "none", "name": "Phosphorylated TTP:mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686715", "map_id": "none", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_450605", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318.", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10686131", "map_id": "none", "name": "Homologues of p-S158,S221-ELAVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10686713", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine158:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10686719", "map_id": "none", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10686123", "map_id": "none", "name": "Homologues of p-S221,S318-ELAVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_517622", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10686717", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine318:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10686111", "map_id": "none", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_450613", "map_id": "none", "name": "mRNA Transcript Targeted by HuR with Unknown Phosphorylation", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10672405", "map_id": "none", "name": "Homologues of ELAVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10686109", "map_id": "none", "name": "HuR with Unknown Phosphorylation: mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10686040", "map_id": "none", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686021", "map_id": "Q55CQ7", "name": "tnpo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686036", "map_id": "Q54MG5", "name": "ZFP36", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450597", "map_id": "none", "name": "mRNA Transcript Targeted by Tristetraproline", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10686038", "map_id": "none", "name": "TTP:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10686059", "map_id": "none", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10686057", "map_id": "none", "name": "TTP:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699437", "map_id": "none", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699426", "map_id": "Q54UC1", "name": "HSF1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10699429", "map_id": "Q54UC1", "name": "phospho-p-S303-HSF1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10699434", "map_id": "P51136", "name": "gskA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272110", "map_id": "DDB_G0272110", "name": "gskA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10699539", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699537", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699547", "map_id": "none", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10699491", "map_id": "none", "name": "HSF1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699508", "map_id": "none", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10684694", "map_id": "Q54GV7", "name": "sir2D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699504", "map_id": "Q86A78", "name": "phospho-DG1124", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699506", "map_id": "none", "name": "p-T454-DBC1:SIRT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10700882", "map_id": "none", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10700878", "map_id": "Q54UC1", "name": "phospho-p-S303,307-HSF1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674717", "map_id": "none", "name": "YWHAE dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10700880", "map_id": "none", "name": "p-S303,307-HSF1:YWHAE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10701046", "map_id": "none", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10701044", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701042", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10701017", "map_id": "Q54UC1", "name": "HSF1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10701036", "map_id": "Q55FM3", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10701966", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5324631", "map_id": "none", "name": "Ub-protein aggregates", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10701961", "map_id": "none", "name": "HSF1:HSP90:HDAC6:VCP:PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10701963", "map_id": "none", "name": "HDAC6:VCP:protein aggregates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10699522", "map_id": "none", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10699510", "map_id": "Q86A78", "name": "DG1124", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10699519", "map_id": "none", "name": "ATM/ATR kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ER4", "map_id": "Q54ER4", "name": "atr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291380", "map_id": "DDB_G0291380", "name": "atr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10701019", "map_id": "none", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10699497", "map_id": "none", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10675699", "map_id": "none", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10675693", "map_id": "none", "name": "CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10672837", "map_id": "none", "name": "CstF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675697", "map_id": "none", "name": "CstF:CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10675695", "map_id": "none", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10672816", "map_id": "none", "name": "CPSF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10675691", "map_id": "none", "name": "capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10697903", "map_id": "none", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10697893", "map_id": "none", "name": "Homologues of GNAT1 (Met removed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2534019", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674265", "map_id": "none", "name": "Homologues of N-(C14:0)-GNAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10697898", "map_id": "Q553B6", "name": "nmt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275863", "map_id": "DDB_G0275863", "name": "nmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10674540", "map_id": "none", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10674512", "map_id": "none", "name": "GUCYs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q553Y7", "map_id": "Q553Y7", "name": "gca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275009", "map_id": "DDB_G0275009", "name": "gca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03101", "map_id": "Q03101", "name": "acgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274569", "map_id": "DDB_G0274569", "name": "acgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674532", "map_id": "Q75K28", "name": "ncsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275931", "map_id": "DDB_G0275931", "name": "ncsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674534", "map_id": "Q75K28", "name": "ncsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10674536", "map_id": "none", "name": "GCAP1:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75K28", "map_id": "Q75K28", "name": "ncsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10674530", "map_id": "none", "name": "GUCA:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10674538", "map_id": "none", "name": "GCAP2:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10698058", "map_id": "none", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10674518", "map_id": "Q75K28", "name": "ncsA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "reaction_10697932", "map_id": "none", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10697913", "map_id": "none", "name": "Homologues of GNAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10697929", "map_id": "none", "name": "METAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55C21", "map_id": "Q55C21", "name": "metap2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270264", "map_id": "DDB_G0270264", "name": "metap2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU3", "map_id": "Q54WU3", "name": "metap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279433", "map_id": "DDB_G0279433", "name": "metap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10685127", "map_id": "none", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685092", "map_id": "none", "name": "Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55F60", "map_id": "Q55F60", "name": "PATL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268244", "map_id": "DDB_G0268244", "name": "PATL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W83", "map_id": "Q54W83", "name": "lsm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279837", "map_id": "DDB_G0279837", "name": "lsm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10685094", "map_id": "none", "name": "Deadenylated mRNA:Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10685125", "map_id": "none", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10685096", "map_id": "none", "name": "Decapped mRNA:LSM1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_430004", "map_id": "CHEBI:20794", "name": "7-MeGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10685122", "map_id": "none", "name": "DCP1-DCP2 Decapping Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54J96", "map_id": "Q54J96", "name": "EDC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288241", "map_id": "DDB_G0288241", "name": "EDC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E49", "map_id": "Q54E49", "name": "ddx6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291804", "map_id": "DDB_G0291804", "name": "ddx6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683236", "map_id": "none", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683208", "map_id": "none", "name": "IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55GJ2", "map_id": "Q55GJ2", "name": "phospho-ireA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267650", "map_id": "DDB_G0267650", "name": "phospho-ireA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DJ9", "map_id": "Q55DJ9", "name": "phospho-irlD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269632", "map_id": "DDB_G0269632", "name": "phospho-irlD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559A2", "map_id": "Q559A2", "name": "phospho-irlA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272987", "map_id": "DDB_G0272987", "name": "phospho-irlA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557G1", "map_id": "Q557G1", "name": "phospho-irlB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273333", "map_id": "DDB_G0273333", "name": "phospho-irlB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DJ8", "map_id": "Q55DJ8", "name": "phospho-irlC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270894", "map_id": "DDB_G0270894", "name": "phospho-irlC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Q3", "map_id": "Q556Q3", "name": "phospho-irlF-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273171", "map_id": "DDB_G0273171", "name": "phospho-irlF-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IE8", "map_id": "Q54IE8", "name": "phospho-irlE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288803", "map_id": "DDB_G0288803", "name": "phospho-irlE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683233", "map_id": "none", "name": "p-S724-IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10683169", "map_id": "none", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683158", "map_id": "none", "name": "Homologues of EIF2AK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10683167", "map_id": "none", "name": "PERK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10683136", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683128", "map_id": "none", "name": "Homologues of ATF6(1-380)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Q90", "map_id": "Q54Q90", "name": "bzpL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284023", "map_id": "DDB_G0284023", "name": "bzpL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU0", "map_id": "Q54WU0", "name": "bzpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279439", "map_id": "DDB_G0279439", "name": "bzpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10683134", "map_id": "none", "name": "Homologues of ATF6(1-380)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10683288", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683284", "map_id": "none", "name": "Homologues of ATF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10683258", "map_id": "none", "name": "Homologues of ATF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10683246", "map_id": "none", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10683243", "map_id": "none", "name": "p-S52-EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10684272", "map_id": "none", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10683264", "map_id": "none", "name": "Homologues of ATF6(1-419)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10684264", "map_id": "none", "name": "Homologues of ATF6(380-419)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10684269", "map_id": "Q552N4", "name": "MBTPS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0275939", "map_id": "DDB_G0275939", "name": "MBTPS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683278", "map_id": "none", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10683270", "map_id": "none", "name": "Homologues of ATF6(420-670)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10683275", "map_id": "Q55C28", "name": "MBTPS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0270252", "map_id": "DDB_G0270252", "name": "MBTPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10683238", "map_id": "none", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10683206", "map_id": "none", "name": "Homologues of ERN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10682271", "map_id": "none", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_265479", "map_id": "LigandDisplayForward?ligandId=6816", "name": "ezetimibe", "type": "complex_component", "sub_type": "other", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10682267", "map_id": "none", "name": "Homologues of NPC1L1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q551C5", "map_id": "Q551C5", "name": "NPC1L1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276657", "map_id": "DDB_G0276657", "name": "NPC1L1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10682269", "map_id": "none", "name": "NPC1L1:ezetimibe", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10687765", "map_id": "none", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10687761", "map_id": "none", "name": "ESCRT-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RC4", "map_id": "Q54RC4", "name": "snf8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283203", "map_id": "DDB_G0283203", "name": "snf8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T18", "map_id": "Q54T18", "name": "vps36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282045", "map_id": "DDB_G0282045", "name": "vps36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GD9", "map_id": "Q55GD9", "name": "vps25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267708", "map_id": "DDB_G0267708", "name": "vps25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687744", "map_id": "none", "name": "ESCRT-I/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54LJ3", "map_id": "Q54LJ3", "name": "tsg101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286797", "map_id": "DDB_G0286797", "name": "tsg101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NF1", "map_id": "Q54NF1", "name": "vps28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285295", "map_id": "DDB_G0285295", "name": "vps28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DV8", "map_id": "Q55DV8", "name": "vps37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269510", "map_id": "DDB_G0269510", "name": "vps37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10687763", "map_id": "none", "name": "ESCRT-II/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10687742", "map_id": "none", "name": "ESCRT-I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10718224", "map_id": "none", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10718207", "map_id": "P36412", "name": "rab11A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "false" }, { "id": "species_10718220", "map_id": "O96904", "name": "phgA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "DDB_G0269130", "map_id": "DDB_G0269130", "name": "phgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718215", "map_id": "none", "name": "Homologues of ULK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "true" }, { "id": "species_10718222", "map_id": "none", "name": "TBC1D14:RAB11:ULK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "O96904", "map_id": "O96904", "name": "phgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718103", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10718076", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10718078", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10718101", "map_id": "none", "name": "Homologues of TBC1D2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WP7", "map_id": "Q54WP7", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295717", "map_id": "DDB_G0295717", "name": "TBC1D2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JG4", "map_id": "Q75JG4", "name": "cnrF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276119", "map_id": "DDB_G0276119", "name": "cnrF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G032", "map_id": "C7G032", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553Q2", "map_id": "Q553Q2", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718045", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10718015", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10718017", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10718043", "map_id": "none", "name": "RAB35 specific TBC RabGAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55F14", "map_id": "Q55F14", "name": "TBC1D13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269052", "map_id": "DDB_G0269052", "name": "TBC1D13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718182", "map_id": "none", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10718176", "map_id": "none", "name": "ATG8 homologues", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10718178", "map_id": "Q54IE1", "name": "TBC1D25", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5683636", "compartment_display": "autophagosome", "complex": "false" }, { "id": "DDB_G0288811", "map_id": "DDB_G0288811", "name": "TBC1D15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10718180", "map_id": "none", "name": "TBC1D25:ATG8 homoogues", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "Q54IE1", "map_id": "Q54IE1", "name": "TBC1D15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10718193", "map_id": "none", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10718188", "map_id": "none", "name": "GGC-RAB4A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10718190", "map_id": "none", "name": "GGC-RAB4A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10718058", "map_id": "none", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_19363", "compartment_display": "microvillus" }, { "id": "species_10718048", "map_id": "Q54RR0", "name": "JFC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172780", "compartment_display": "microvillus membrane", "complex": "false" }, { "id": "species_10718054", "map_id": "none", "name": "Homologues of TBC1D10A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_19363", "compartment_display": "microvillus", "complex": "true" }, { "id": "species_10718056", "map_id": "none", "name": "TBC1D10A:JFC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_172780", "compartment_display": "microvillus membrane", "complex": "true" }, { "id": "reaction_10718135", "map_id": "none", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10718131", "map_id": "none", "name": "Homologues of RABGAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54H32", "map_id": "Q54H32", "name": "RABGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289735", "map_id": "DDB_G0289735", "name": "RABGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KE5", "map_id": "Q54KE5", "name": "RABGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550W0", "map_id": "Q550W0", "name": "AF310892_3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276961", "map_id": "DDB_G0276961", "name": "AF310892_3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IZ7", "map_id": "Q54IZ7", "name": "RABGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10716961", "map_id": "none", "name": "RAB6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10718133", "map_id": "none", "name": "RABGAP1:RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10687717", "map_id": "none", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10687496", "map_id": "none", "name": "ESCRT-III/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10687276", "map_id": "Q86H98", "name": "chmp4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687698", "map_id": "none", "name": "Ubiquinated and PIP3 Endosmal Membrane Bound Cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "species_10687290", "map_id": "Q54JK4", "name": "chmp5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687285", "map_id": "Q54KZ4", "name": "chmp6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687266", "map_id": "Q54GK9", "name": "chmp2a1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687271", "map_id": "Q54P63", "name": "chmp3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10687714", "map_id": "none", "name": "Vps/Vta1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55B11", "map_id": "Q55B11", "name": "vta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271488", "map_id": "DDB_G0271488", "name": "vta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10687767", "map_id": "none", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10718204", "map_id": "none", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10718199", "map_id": "none", "name": "RAB33:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10718201", "map_id": "none", "name": "RAB33:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10718173", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10718163", "map_id": "none", "name": "RAB7:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10718165", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10718171", "map_id": "Q54IE1", "name": "TBC1D15", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10722615", "map_id": "none", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674916" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10677345": { "compartment": "compartment_7660", "id": "reaction_10677345", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674902" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10677349": { "compartment": "compartment_7660", "id": "reaction_10677349", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10677347" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10696321": { "compartment": "compartment_876", "id": "reaction_10696321", "reactome": "R-DDI-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696053" ], "products": [ "species_10696319", "species_10696293" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696409": { "compartment": "compartment_984", "id": "reaction_10696409", "reactome": "R-DDI-2168038", "name": "Collagen type XV restin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696351" ], "products": [ "species_10696407", "species_10696403" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697814": { "compartment": "compartment_984", "id": "reaction_10697814", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695841" ], "products": [ "species_10697743" ], "modifiers": [ [ "species_10697811", "catalyst" ] ], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696557": { "compartment": "compartment_984", "id": "reaction_10696557", "reactome": "R-DDI-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696458" ], "products": [ "species_10696464", "species_10696490" ], "modifiers": [ [ "species_10696554", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696587": { "compartment": "compartment_984", "id": "reaction_10696587", "reactome": "R-DDI-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696585" ], "products": [], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585" ] }, "reaction_10697697": { "compartment": "compartment_984", "id": "reaction_10697697", "reactome": "R-DDI-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696490" ], "products": [], "modifiers": [ [ "species_10697694", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10700000": { "compartment": "compartment_984", "id": "reaction_10700000", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692323" ], "products": [ "species_10699995", "species_10699997" ], "modifiers": [ [ "species_10696532", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10677776": { "compartment": "compartment_70101", "id": "reaction_10677776", "reactome": "R-DDI-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677695" ], "products": [ "species_10677763", "species_29370" ], "modifiers": [ [ "species_10677773", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54HS0", "DDB_G0289277" ] }, "reaction_10721800": { "compartment": "compartment_70101", "id": "reaction_10721800", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685829" ], "products": [ "species_10680841", "species_10721798" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10710974": { "compartment": "compartment_70101", "id": "reaction_10710974", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689687" ], "products": [ "species_10689719" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722948": { "compartment": "compartment_70101", "id": "reaction_10722948", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722934" ], "products": [ "species_10722946" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711315": { "compartment": "compartment_17957", "id": "reaction_10711315", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10711313" ], "modifiers": [ [ "species_10689719", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721951": { "compartment": "compartment_70101", "id": "reaction_10721951", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721937" ], "products": [ "species_10721949" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711217": { "compartment": "compartment_70101", "id": "reaction_10711217", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711213" ], "products": [ "species_10711215" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689919": { "compartment": "compartment_70101", "id": "reaction_10689919", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689914", "species_10689903" ], "products": [ "species_10689901", "species_10687967", "species_111294", "species_76577", "species_10689916" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54FR5", "DDB_G0290629", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10722886": { "compartment": "compartment_70101", "id": "reaction_10722886", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722870" ], "products": [ "species_10722884" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689924": { "compartment": "compartment_70101", "id": "reaction_10689924", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689905", "species_10687967" ], "products": [ "species_10689897", "species_10687972" ], "modifiers": [ [ "species_10687967", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10723442": { "compartment": "compartment_984", "id": "reaction_10723442", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10682859" ], "products": [ "species_10723440" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10722811": { "compartment": "compartment_70101", "id": "reaction_10722811", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722797" ], "products": [ "species_10722809" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689723": { "compartment": "compartment_70101", "id": "reaction_10689723", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689691" ], "products": [ "species_10689721" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10687013": { "compartment": "compartment_7660", "id": "reaction_10687013", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687009", "species_10686997", "species_10686965" ], "products": [ "species_10687011" ], "modifiers": [], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q8N0B4", "DDB_G0286189", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q555X5", "DDB_G0274743", "O00910", "DDB_G0281381", "Q55FZ7", "DDB_G0267886", "Q54BD4", "DDB_G0293532", "Q54V57", "DDB_G0280603" ] }, "reaction_10721796": { "compartment": "compartment_70101", "id": "reaction_10721796", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685818", "species_10685820" ], "products": [ "species_10685822" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722845": { "compartment": "compartment_70101", "id": "reaction_10722845", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722809" ], "products": [ "species_10722843" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685968": { "compartment": "compartment_70101", "id": "reaction_10685968", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685956", "species_113592" ], "products": [ "species_29370", "species_10677773" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10726042": { "compartment": "compartment_70101", "id": "reaction_10726042", "reactome": "R-DDI-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726002", "species_10687129" ], "products": [ "species_10726040" ], "modifiers": [], "additional_components": [ "DDB_G0273149", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q557F4", "DDB_G0273149" ] }, "reaction_10710976": { "compartment": "compartment_70101", "id": "reaction_10710976", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683" ], "products": [ "species_10689687" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721987": { "compartment": "compartment_70101", "id": "reaction_10721987", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721983" ], "products": [ "species_10721985" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721981": { "compartment": "compartment_70101", "id": "reaction_10721981", "reactome": "R-DDI-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721977" ], "products": [ "species_10721979" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685976": { "compartment": "compartment_70101", "id": "reaction_10685976", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685974" ], "products": [ "species_29370", "species_10685942" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10689693": { "compartment": "compartment_70101", "id": "reaction_10689693", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689685" ], "products": [ "species_10689691" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685950": { "compartment": "compartment_70101", "id": "reaction_10685950", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685942" ], "products": [ "species_10685948" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10722868": { "compartment": "compartment_70101", "id": "reaction_10722868", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722797" ], "products": [ "species_10722866" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722872": { "compartment": "compartment_70101", "id": "reaction_10722872", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722860" ], "products": [ "species_10722870" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721989": { "compartment": "compartment_70101", "id": "reaction_10721989", "reactome": "R-DDI-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689689" ], "products": [ "species_10689717" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686004": { "compartment": "compartment_70101", "id": "reaction_10686004", "reactome": "R-DDI-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677763" ], "products": [ "species_10686002" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10718623": { "compartment": "compartment_7660", "id": "reaction_10718623", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718594", "species_10718601" ], "products": [ "species_10718621" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0267402", "Q54MP8", "DDB_G0285837", "O15819", "DDB_G0267402" ] }, "reaction_10685884": { "compartment": "compartment_984", "id": "reaction_10685884", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10685874" ], "products": [ "species_10685876" ], "modifiers": [ [ "species_10685882", "inhibitor" ] ], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231", "Q54YE6", "DDB_G0284903", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q54QC8", "DDB_G0283937", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10693415": { "compartment": "compartment_70101", "id": "reaction_10693415", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693390", "species_10689903" ], "products": [ "species_10693392" ], "modifiers": [], "additional_components": [ "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979" ] }, "reaction_10685832": { "compartment": "compartment_70101", "id": "reaction_10685832", "reactome": "R-DDI-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685822" ], "products": [ "species_10685829" ], "modifiers": [ [ "species_10685822", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722864": { "compartment": "compartment_70101", "id": "reaction_10722864", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722860" ], "products": [ "species_10722862" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10693413": { "compartment": "compartment_70101", "id": "reaction_10693413", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693409", "species_10693392" ], "products": [ "species_10693411", "species_10693407" ], "modifiers": [], "additional_components": [ "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406" ] }, "reaction_10686967": { "compartment": "compartment_13231", "id": "reaction_10686967", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686953" ], "products": [ "species_10686965" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722952": { "compartment": "compartment_70101", "id": "reaction_10722952", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722932" ], "products": [ "species_10722934" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685932": { "compartment": "compartment_70101", "id": "reaction_10685932", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685816", "species_10685814" ], "products": [ "species_10685818" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10680392": { "compartment": "compartment_7660", "id": "reaction_10680392", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10680389", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10718598": { "compartment": "compartment_7660", "id": "reaction_10718598", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698721", "species_10718594" ], "products": [ "species_10718596" ], "modifiers": [], "additional_components": [ "DDB_G0285205", "DDB_G0285837", "Q54MP8", "DDB_G0285837", "Q55C32", "DDB_G0285205" ] }, "reaction_10689908": { "compartment": "compartment_70101", "id": "reaction_10689908", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687972", "species_10687957", "species_113592" ], "products": [ "species_10689905", "species_111294", "species_76577" ], "modifiers": [ [ "species_10687972", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10721991": { "compartment": "compartment_70101", "id": "reaction_10721991", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721935" ], "products": [ "species_10721937" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686171": { "compartment": "compartment_70101", "id": "reaction_10686171", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686160" ], "products": [ "species_10686168" ], "modifiers": [ [ "species_10686160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10722999": { "compartment": "compartment_70101", "id": "reaction_10722999", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683071", "species_113592" ], "products": [ "species_10722807", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711221": { "compartment": "compartment_70101", "id": "reaction_10711221", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711215" ], "products": [ "species_10711219" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721993": { "compartment": "compartment_70101", "id": "reaction_10721993", "reactome": "R-DDI-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10721935" ], "products": [ "species_10721983" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722966": { "compartment": "compartment_70101", "id": "reaction_10722966", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722920" ], "products": [ "species_10722964" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711033": { "compartment": "compartment_70101", "id": "reaction_10711033", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711027" ], "products": [ "species_10711031" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721995": { "compartment": "compartment_70101", "id": "reaction_10721995", "reactome": "R-DDI-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10687127" ], "products": [ "species_10689689" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722989": { "compartment": "compartment_984", "id": "reaction_10722989", "reactome": "R-DDI-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10689912": { "compartment": "compartment_70101", "id": "reaction_10689912", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687957", "species_10688804" ], "products": [ "species_10689910" ], "modifiers": [], "additional_components": [ "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063", "Q54CI1", "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10689954": { "compartment": "compartment_70101", "id": "reaction_10689954", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689950", "species_10689903" ], "products": [ "species_10689901", "species_10689952", "species_10687967", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10693385": { "compartment": "compartment_70101", "id": "reaction_10693385", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689952" ], "products": [ "species_141681", "species_10689950" ], "modifiers": [ [ "species_10693382", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q54H96", "DDB_G0289611" ] }, "reaction_10711065": { "compartment": "compartment_70101", "id": "reaction_10711065", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711031" ], "products": [ "species_10711063" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10723438": { "compartment": "compartment_984", "id": "reaction_10723438", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10723434" ], "products": [ "species_10723436" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10689921": { "compartment": "compartment_70101", "id": "reaction_10689921", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689901", "species_10689897" ], "products": [ "species_10689903" ], "modifiers": [], "additional_components": [ "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10681044": { "compartment": "compartment_7660", "id": "reaction_10681044", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10681041", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54CK7", "DDB_G0292880", "Q55CS8", "DDB_G0270688", "Q55CS7", "DDB_G0269918", "Q8T813", "DDB_G0292880", "Q54N84", "DDB_G0292880", "Q55BI8", "DDB_G0292880", "Q556Y8", "DDB_G0292880" ] }, "reaction_10722922": { "compartment": "compartment_70101", "id": "reaction_10722922", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721965" ], "products": [ "species_10722920" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10700120": { "compartment": "compartment_70101", "id": "reaction_10700120", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10700111" ], "products": [ "species_29370", "species_10700117" ], "modifiers": [ [ "species_10700111", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10700113": { "compartment": "compartment_876", "id": "reaction_10700113", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681384", "species_10683631" ], "products": [ "species_10700111" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10680511": { "compartment": "compartment_70101", "id": "reaction_10680511", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674849", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10686784": { "compartment": "compartment_70101", "id": "reaction_10686784", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10686781", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10686779": { "compartment": "compartment_70101", "id": "reaction_10686779", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548794", "species_29508" ], "products": [ "species_76194", "species_113528", "species_548829" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10680602": { "compartment": "compartment_70101", "id": "reaction_10680602", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10680599", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10718402": { "compartment": "compartment_5460", "id": "reaction_10718402", "reactome": "R-DDI-8862152", "name": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8862377", "species_113600", "species_113529" ], "products": [ "species_113563", "species_8862371" ], "modifiers": [ [ "species_10718399", "catalyst" ] ], "additional_components": [ "Q75JT8", "DDB_G0272154", "Q55E82", "DDB_G0269356" ] }, "reaction_10710291": { "compartment": "compartment_70101", "id": "reaction_10710291", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_5695985", "species_113592" ], "products": [ "species_5695971", "species_111294", "species_76577" ], "modifiers": [ [ "species_10710288", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10686794": { "compartment": "compartment_70101", "id": "reaction_10686794", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10686789", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10674838": { "compartment": "compartment_70101", "id": "reaction_10674838", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10674835", "catalyst" ] ], "additional_components": [ "Q54YA0", "DDB_G0278345" ] }, "reaction_10677353": { "compartment": "compartment_70101", "id": "reaction_10677353", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674902" ], "products": [ "species_10674904" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10709494": { "compartment": "compartment_161320", "id": "reaction_10709494", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10709491", "catalyst" ] ], "additional_components": [ "species_6785219", "species_400452", "DDB_G0288807" ] }, "reaction_10710299": { "compartment": "compartment_5460", "id": "reaction_10710299", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_5696003", "species_159450" ], "modifiers": [ [ "species_10710296", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10686768": { "compartment": "compartment_70101", "id": "reaction_10686768", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10674907": { "compartment": "compartment_70101", "id": "reaction_10674907", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10674904", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10686777": { "compartment": "compartment_70101", "id": "reaction_10686777", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10709097": { "compartment": "compartment_161320", "id": "reaction_10709097", "reactome": "R-DDI-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10709094", "catalyst" ] ], "additional_components": [ "Q54N35", "DDB_G0288807", "Q54IE5", "DDB_G0288807" ] }, "reaction_10722585": { "compartment": "compartment_5460", "id": "reaction_10722585", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10722582", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10704723": { "compartment": "compartment_12045", "id": "reaction_10704723", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10704720", "catalyst" ] ], "additional_components": [ "Q54YR9", "DDB_G0278113", "Q54Y54", "DDB_G0278683" ] }, "reaction_10723486": { "compartment": "compartment_70101", "id": "reaction_10723486", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_9014643", "species_29356" ], "modifiers": [ [ "species_10723483", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10723494": { "compartment": "compartment_70101", "id": "reaction_10723494", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10723491", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10724544": { "compartment": "compartment_74700", "id": "reaction_10724544", "reactome": "R-DDI-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724541", "species_113592" ], "products": [ "species_29370", "species_10724523" ], "modifiers": [ [ "species_10724541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10680187": { "compartment": "compartment_7660", "id": "reaction_10680187", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680183" ], "products": [ "species_10680185" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10724539": { "compartment": "compartment_70101", "id": "reaction_10724539", "reactome": "R-DDI-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724527", "species_113592" ], "products": [ "species_29370", "species_10724536" ], "modifiers": [ [ "species_10724527", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10678590": { "compartment": "compartment_876", "id": "reaction_10678590", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678586", "species_10678454" ], "products": [ "species_10678588" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54VD5", "DDB_G0280437", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "species_29438", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724534": { "compartment": "compartment_74700", "id": "reaction_10724534", "reactome": "R-DDI-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10724525" ], "products": [ "species_10724527", "species_29370" ], "modifiers": [ [ "species_10724525", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10724561": { "compartment": "compartment_7660", "id": "reaction_10724561", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10724549" ], "products": [ "species_113582", "species_10724552" ], "modifiers": [ [ "species_10724558", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10724023": { "compartment": "compartment_70101", "id": "reaction_10724023", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9026307" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10724019": { "compartment": "compartment_70101", "id": "reaction_10724019", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026293" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724021": { "compartment": "compartment_70101", "id": "reaction_10724021", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10692055": { "compartment": "compartment_70101", "id": "reaction_10692055", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680794", "species_1497857" ], "products": [ "species_29870", "species_10692053" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680817": { "compartment": "compartment_70101", "id": "reaction_10680817", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680768", "species_10680089" ], "products": [ "species_10680776" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680970": { "compartment": "compartment_20699", "id": "reaction_10680970", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680934" ], "products": [ "species_10680751" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680960": { "compartment": "compartment_876", "id": "reaction_10680960", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751" ], "products": [ "species_76168", "species_10680805" ], "modifiers": [ [ "species_10680957", "catalyst" ] ], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "Q54T49", "DDB_G0282005" ] }, "reaction_10692058": { "compartment": "compartment_70101", "id": "reaction_10692058", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10692053", "catalyst" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680792": { "compartment": "compartment_70101", "id": "reaction_10680792", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680776" ], "products": [ "species_29370", "species_10680790" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10692064": { "compartment": "compartment_70101", "id": "reaction_10692064", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_1497811" ], "products": [ "species_29366", "species_1497857" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10680815": { "compartment": "compartment_20699", "id": "reaction_10680815", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680805" ], "products": [ "species_10680813" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680942": { "compartment": "compartment_20699", "id": "reaction_10680942", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680803", "species_200993" ], "products": [ "species_10680934" ], "modifiers": [ [ "species_10680939", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "DDB_G0278239" ] }, "reaction_10692051": { "compartment": "compartment_70101", "id": "reaction_10692051", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10680790" ], "products": [ "species_10680794" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680797": { "compartment": "compartment_70101", "id": "reaction_10680797", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10680794", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680950": { "compartment": "compartment_70101", "id": "reaction_10680950", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10680948" ], "products": [ "species_10680803" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10685205": { "compartment": "compartment_70101", "id": "reaction_10685205", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10685202", "catalyst" ] ], "additional_components": [ "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769", "Q54HV0", "DDB_G0289175", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q86K90", "DDB_G0277211", "Q54EV5", "DDB_G0291310", "Q54S59", "DDB_G0282793", "Q54VM4", "DDB_G0280251" ] }, "reaction_10690044": { "compartment": "compartment_7660", "id": "reaction_10690044", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690036", "species_10690021" ], "products": [ "species_10690042" ], "modifiers": [], "additional_components": [ "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690384": { "compartment": "compartment_7660", "id": "reaction_10690384", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690021" ], "products": [ "species_10690382" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690040": { "compartment": "compartment_7660", "id": "reaction_10690040", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690036" ], "products": [ "species_10690038" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690376": { "compartment": "compartment_7660", "id": "reaction_10690376", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690372" ], "products": [ "species_10690374" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690388": { "compartment": "compartment_7660", "id": "reaction_10690388", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690019" ], "products": [ "species_10690386" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690380": { "compartment": "compartment_7660", "id": "reaction_10690380", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10689991" ], "products": [ "species_10690378" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679987": { "compartment": "compartment_70101", "id": "reaction_10679987", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10679984", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10679977": { "compartment": "compartment_70101", "id": "reaction_10679977", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10679974", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10701666": { "compartment": "compartment_13231", "id": "reaction_10701666", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10700336", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10699545": { "compartment": "compartment_70101", "id": "reaction_10699545", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699541", "species_10699543" ], "products": [ "species_10699415" ], "modifiers": [], "additional_components": [ "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_113592", "P36415", "DDB_G0269144", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568" ] }, "reaction_10702418": { "compartment": "compartment_70101", "id": "reaction_10702418", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699485" ], "products": [ "species_10702412" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "species_113592", "Q54DA8", "DDB_G0292404", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400" ] }, "reaction_10699420": { "compartment": "compartment_70101", "id": "reaction_10699420", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699415" ], "products": [ "species_10699417", "species_29372" ], "modifiers": [ [ "species_10699415", "catalyst" ], [ "species_10699413", "catalyst" ] ], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10699487": { "compartment": "compartment_70101", "id": "reaction_10699487", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699417", "species_10699479", "species_10699473" ], "products": [ "species_10699413", "species_10699485" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "DDB_G0292404", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400" ] }, "reaction_10678193": { "compartment": "compartment_5460", "id": "reaction_10678193", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678182", "species_73663" ], "products": [ "species_76633", "species_10678180" ], "modifiers": [ [ "species_10678190", "catalyst" ] ], "additional_components": [ "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10677420": { "compartment": "compartment_70616", "id": "reaction_10677420", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_76633", "species_113529", "species_73663" ], "products": [ "species_10677282", "species_76633", "species_163953", "species_73663" ], "modifiers": [ [ "species_10677417", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q54M82", "DDB_G0286171", "Q4W6B5", "DDB_G0288777", "Q86A84", "DDB_G0274809", "Q54D07", "DDB_G0292594", "Q37311", "DDB_G0294078", "Q1ZXP3", "DDB_G0271774", "Q54QR8", "DDB_G0283669", "Q54F93", "DDB_G0290997" ] }, "reaction_10709072": { "compartment": "compartment_5460", "id": "reaction_10709072", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10709068" ], "products": [ "species_10709070" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10714760": { "compartment": "compartment_5460", "id": "reaction_10714760", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714105", "species_10711174", "species_10714098", "species_10714110", "species_10711176" ], "products": [ "species_10714112" ], "modifiers": [], "additional_components": [ "Q559Z0", "DDB_G0272266", "species_113596", "Q54NI6", "DDB_G0285239", "Q54S83", "DDB_G0282615", "Q23883", "DDB_G0294030", "DDB_G0294032", "Q86K57", "DDB_G0277231", "P22237", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "species_113596" ] }, "reaction_10678185": { "compartment": "compartment_5460", "id": "reaction_10678185", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678180", "species_31649" ], "products": [ "species_113596", "species_10678182" ], "modifiers": [ [ "species_10678180", "catalyst" ] ], "additional_components": [ "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10711196": { "compartment": "compartment_5460", "id": "reaction_10711196", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711190", "species_10711185", "species_10709070", "species_76629" ], "products": [ "species_10711194", "species_10711192", "species_10709068" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "Q54F10", "DDB_G0291173", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193" ] }, "reaction_10711180": { "compartment": "compartment_5460", "id": "reaction_10711180", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709070", "species_10711168" ], "products": [ "species_10711178", "species_10709068" ], "modifiers": [], "additional_components": [ "Q54F15", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "DDB_G0291193" ] }, "reaction_10716369": { "compartment": "compartment_7660", "id": "reaction_10716369", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10716366", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10714921": { "compartment": "compartment_7660", "id": "reaction_10714921", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10714909" ], "products": [ "species_113582", "species_10714919" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721110": { "compartment": "compartment_7660", "id": "reaction_10721110", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721103", "species_10687932" ], "products": [ "species_10721108" ], "modifiers": [], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0268618", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q55EZ0", "DDB_G0268618", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10721106": { "compartment": "compartment_7660", "id": "reaction_10721106", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721092", "species_29358" ], "products": [ "species_113582", "species_10721103" ], "modifiers": [ [ "species_10685946", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10716021": { "compartment": "compartment_7660", "id": "reaction_10716021", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700208", "species_6810408" ], "products": [ "species_10716019" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "species_6810408", "Q54PN9", "DDB_G0284411" ] }, "reaction_10671182": { "compartment": "compartment_5460", "id": "reaction_10671182", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10671179", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10722466": { "compartment": "compartment_5460", "id": "reaction_10722466", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10710922", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10690088": { "compartment": "compartment_70101", "id": "reaction_10690088", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10690056": { "compartment": "compartment_70101", "id": "reaction_10690056", "reactome": "R-DDI-1237069", "name": "RHAG transports CO2 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237009" ], "products": [ "species_113528" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10702542": { "compartment": "compartment_70101", "id": "reaction_10702542", "reactome": "R-DDI-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10702540" ], "products": [ "species_10702524", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "species_29438", "Q54V41", "DDB_G0280633", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10723639": { "compartment": "compartment_70101", "id": "reaction_10723639", "reactome": "R-DDI-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723634" ], "products": [ "species_29372", "species_10723636" ], "modifiers": [ [ "species_10723261", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723645": { "compartment": "compartment_70101", "id": "reaction_10723645", "reactome": "R-DDI-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723641", "species_10723634" ], "products": [ "species_10723643" ], "modifiers": [], "additional_components": [ "Q54ND2", "DDB_G0285391", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q55GN5", "DDB_G0267590", "Q54XT6", "DDB_G0278755", "O00899", "DDB_G0269140", "Q54FF4", "DDB_G0290891", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "Q1ZXA8", "DDB_G0292160", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q1ZXJ6", "DDB_G0278011", "Q55GN5", "DDB_G0267590", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "P34145", "DDB_G0268622", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q54XT6", "DDB_G0278755", "species_29438", "O00899", "DDB_G0269140", "Q9GPR7", "DDB_G0269240", "Q54FF4", "DDB_G0290891", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q869N2", "DDB_G0276459" ] }, "reaction_10723650": { "compartment": "compartment_876", "id": "reaction_10723650", "reactome": "R-DDI-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723636" ], "products": [ "species_29420", "species_10723634" ], "modifiers": [ [ "species_10723647", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54PK2", "DDB_G0291085", "Q54F64", "DDB_G0291085", "Q54J11", "DDB_G0288383", "Q54MM3", "DDB_G0285859", "Q54B37", "DDB_G0293978", "Q54KI4", "DDB_G0287325", "Q1ZXN6", "DDB_G0272372" ] }, "reaction_10723940": { "compartment": "compartment_876", "id": "reaction_10723940", "reactome": "R-DDI-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723634" ], "products": [ "species_10723938" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10705788": { "compartment": "compartment_7660", "id": "reaction_10705788", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705770", "species_10705784" ], "products": [ "species_10705786" ], "modifiers": [], "additional_components": [ "Q557E6", "DDB_G0273139", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q1ZXF0", "DDB_G0285287", "Q557E6", "DDB_G0273139", "Q54ED2", "DDB_G0291570", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q54DM3", "DDB_G0292130", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q8T2T7", "DDB_G0275257", "Q1ZXF0", "DDB_G0285287", "Q86IV6", "DDB_G0274777" ] }, "reaction_10705715": { "compartment": "compartment_7660", "id": "reaction_10705715", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705710" ], "products": [ "species_113582", "species_10705713" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10705801": { "compartment": "compartment_7660", "id": "reaction_10705801", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705796" ], "products": [ "species_30555", "species_10705798" ], "modifiers": [ [ "species_10705796", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546" ] }, "reaction_10674992": { "compartment": "compartment_7660", "id": "reaction_10674992", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988" ], "products": [ "species_10674990" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10710990": { "compartment": "compartment_7660", "id": "reaction_10710990", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710986", "species_10710981" ], "products": [ "species_10710988" ], "modifiers": [], "additional_components": [ "DDB_G0293476", "DDB_G0268216", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10722017": { "compartment": "compartment_70101", "id": "reaction_10722017", "reactome": "R-DDI-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722004", "species_113592", "species_10709503" ], "products": [ "species_10722014", "species_111294", "species_76577" ], "modifiers": [ [ "species_10722004", "catalyst" ] ], "additional_components": [ "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722037": { "compartment": "compartment_70101", "id": "reaction_10722037", "reactome": "R-DDI-8951661", "name": "Transfer of NEDD8 to AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722026" ], "products": [ "species_10722034", "species_10722014" ], "modifiers": [ [ "species_10722026", "catalyst" ] ], "additional_components": [ "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722288": { "compartment": "compartment_7660", "id": "reaction_10722288", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722257", "species_10722191", "species_10722245" ], "products": [ "species_10722259" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10709510": { "compartment": "compartment_70101", "id": "reaction_10709510", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709501", "species_29356" ], "products": [ "species_10709507", "species_10709505" ], "modifiers": [ [ "species_10709501", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10722444": { "compartment": "compartment_70101", "id": "reaction_10722444", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10722440" ], "products": [ "species_10722442" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436" ] }, "reaction_10722556": { "compartment": "compartment_7660", "id": "reaction_10722556", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722283" ], "products": [ "species_10722553", "species_10722551" ], "modifiers": [ [ "species_10709642", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q550I8", "DDB_G0277089", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0278711", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10722452": { "compartment": "compartment_7660", "id": "reaction_10722452", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722448", "species_10722243" ], "products": [ "species_10722245", "species_10722446" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "DDB_G0274167" ] }, "reaction_10722571": { "compartment": "compartment_70101", "id": "reaction_10722571", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722567", "species_10722562" ], "products": [ "species_10722569" ], "modifiers": [], "additional_components": [ "DDB_G0270358", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q55BU7", "DDB_G0270358", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201" ] }, "reaction_10722039": { "compartment": "compartment_70101", "id": "reaction_10722039", "reactome": "R-DDI-8951751", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722024", "species_10722019" ], "products": [ "species_10722026" ], "modifiers": [], "additional_components": [ "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722021": { "compartment": "compartment_70101", "id": "reaction_10722021", "reactome": "R-DDI-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10722014", "species_10709503" ], "products": [ "species_111294", "species_76577", "species_10722019" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722450": { "compartment": "compartment_7660", "id": "reaction_10722450", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722219", "species_10722446" ], "products": [ "species_10722448" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "DDB_G0274167", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565" ] }, "reaction_10722460": { "compartment": "compartment_70101", "id": "reaction_10722460", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722118", "species_10722442" ], "products": [ "species_10722458", "species_10709665" ], "modifiers": [], "additional_components": [ "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0274167" ] }, "reaction_10722577": { "compartment": "compartment_876", "id": "reaction_10722577", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722160", "species_10722178" ], "products": [ "species_10722180" ], "modifiers": [], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "DDB_G0290025", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722182": { "compartment": "compartment_70101", "id": "reaction_10722182", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722162" ], "products": [ "species_10722174", "species_10722024" ], "modifiers": [ [ "species_10722162", "catalyst" ], [ "species_10722180", "inhibitor" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722185": { "compartment": "compartment_70101", "id": "reaction_10722185", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722143", "species_10722034", "species_10722160" ], "products": [ "species_10722162" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722286": { "compartment": "compartment_7660", "id": "reaction_10722286", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722259" ], "products": [ "species_10722283", "species_10722261" ], "modifiers": [ [ "species_10722259", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722549": { "compartment": "compartment_70101", "id": "reaction_10722549", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722536" ], "products": [ "species_10722546", "species_10709503" ], "modifiers": [ [ "species_10718564", "catalyst" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q8T2F2", "DDB_G0277439", "Q54DR0", "DDB_G0292074", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0278711", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10721997": { "compartment": "compartment_70101", "id": "reaction_10721997", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709505" ], "products": [ "species_10709192", "species_10709503" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0282007", "DDB_G0278711" ] }, "reaction_10678743": { "compartment": "compartment_70101", "id": "reaction_10678743", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670505", "species_10670510" ], "products": [ "species_10670512" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678860": { "compartment": "compartment_70101", "id": "reaction_10678860", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678797" ], "products": [ "species_10676841", "species_10670505" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0285601", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10680376": { "compartment": "compartment_7660", "id": "reaction_10680376", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10680349" ], "products": [ "species_113582", "species_10680353" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10699967": { "compartment": "compartment_7660", "id": "reaction_10699967", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699958", "species_10669917" ], "products": [ "species_10699964" ], "modifiers": [ [ "species_10699958", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699948": { "compartment": "compartment_7660", "id": "reaction_10699948", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699950": { "compartment": "compartment_7660", "id": "reaction_10699950", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10691859": { "compartment": "compartment_12045", "id": "reaction_10691859", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10691856", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10692020": { "compartment": "compartment_12045", "id": "reaction_10692020", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10692017", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10692009": { "compartment": "compartment_12045", "id": "reaction_10692009", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10692006", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10692047": { "compartment": "compartment_70101", "id": "reaction_10692047", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10692044", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10676812": { "compartment": "compartment_70101", "id": "reaction_10676812", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29356", "species_209914" ], "products": [ "species_29408", "species_29382", "species_500604" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683049": { "compartment": "compartment_5460", "id": "reaction_10683049", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10676257": { "compartment": "compartment_70101", "id": "reaction_10676257", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676252" ], "products": [ "species_10676252" ], "modifiers": [ [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q23917", "DDB_G0284331", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10676146": { "compartment": "compartment_70101", "id": "reaction_10676146", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10676255": { "compartment": "compartment_70101", "id": "reaction_10676255", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676252", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331" ] }, "reaction_10676273": { "compartment": "compartment_70101", "id": "reaction_10676273", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676143", "species_29356" ], "products": [ "species_10676101", "species_29372", "species_10676271" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "DDB_G0292736", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10676198": { "compartment": "compartment_7660", "id": "reaction_10676198", "reactome": "R-DDI-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676189" ], "products": [ "species_113582", "species_10676195" ], "modifiers": [ [ "species_10676189", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831" ] }, "reaction_10676157": { "compartment": "compartment_70101", "id": "reaction_10676157", "reactome": "R-DDI-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_74016", "species_10676153" ], "products": [ "species_10676155" ], "modifiers": [], "additional_components": [ "DDB_G0292858", "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676160": { "compartment": "compartment_12045", "id": "reaction_10676160", "reactome": "R-DDI-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10676155", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676234": { "compartment": "compartment_876", "id": "reaction_10676234", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10676221", "catalyst" ], [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10685523": { "compartment": "compartment_70101", "id": "reaction_10685523", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10685515" ], "products": [ "species_113582", "species_10685520" ], "modifiers": [ [ "species_10685515", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10671131": { "compartment": "compartment_5460", "id": "reaction_10671131", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10682718": { "compartment": "compartment_70101", "id": "reaction_10682718", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10682713", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10671817": { "compartment": "compartment_70101", "id": "reaction_10671817", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10671014": { "compartment": "compartment_70101", "id": "reaction_10671014", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29800" ], "products": [ "species_29578", "species_29360", "species_29372" ], "modifiers": [ [ "species_10670947", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10682769": { "compartment": "compartment_5460", "id": "reaction_10682769", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10682766", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10682774": { "compartment": "compartment_70101", "id": "reaction_10682774", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10670994": { "compartment": "compartment_70101", "id": "reaction_10670994", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670989", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10671814": { "compartment": "compartment_70101", "id": "reaction_10671814", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10671811", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10671030": { "compartment": "compartment_70101", "id": "reaction_10671030", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10671027", "catalyst" ] ], "additional_components": [ "Q9GPM4", "DDB_G0287595", "species_29926" ] }, "reaction_10680112": { "compartment": "compartment_70101", "id": "reaction_10680112", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10682918": { "compartment": "compartment_70101", "id": "reaction_10682918", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10671010": { "compartment": "compartment_70101", "id": "reaction_10671010", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10671007", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10670833": { "compartment": "compartment_70101", "id": "reaction_10670833", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10670830", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10680122": { "compartment": "compartment_70101", "id": "reaction_10680122", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10680119", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10671057": { "compartment": "compartment_70101", "id": "reaction_10671057", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29492", "species_29356" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10671054", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "species_29926", "Q55F83", "DDB_G0268214" ] }, "reaction_10671012": { "compartment": "compartment_70101", "id": "reaction_10671012", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10670957", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10698893": { "compartment": "compartment_70101", "id": "reaction_10698893", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698875" ], "products": [ "species_10698877" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698891": { "compartment": "compartment_70101", "id": "reaction_10698891", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698877" ], "products": [ "species_10698889" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698905": { "compartment": "compartment_70101", "id": "reaction_10698905", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10698903" ], "products": [ "species_10698875", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10690190": { "compartment": "compartment_876", "id": "reaction_10690190", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690187", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10691628": { "compartment": "compartment_12045", "id": "reaction_10691628", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691786": { "compartment": "compartment_12045", "id": "reaction_10691786", "reactome": "R-DDI-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691783": { "compartment": "compartment_12045", "id": "reaction_10691783", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691780", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691768": { "compartment": "compartment_12045", "id": "reaction_10691768", "reactome": "R-DDI-1482827", "name": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691760": { "compartment": "compartment_12045", "id": "reaction_10691760", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691757", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858", "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691643": { "compartment": "compartment_12045", "id": "reaction_10691643", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10720446": { "compartment": "compartment_12045", "id": "reaction_10720446", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10720443", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "DDB_G0275665" ] }, "reaction_10676046": { "compartment": "compartment_7660", "id": "reaction_10676046", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676042" ], "products": [ "species_10676044", "species_10675681" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10676048": { "compartment": "compartment_7660", "id": "reaction_10676048", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675681" ], "products": [ "species_10676042" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10725757": { "compartment": "compartment_7660", "id": "reaction_10725757", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725753", "species_10677256" ], "products": [ "species_10725755" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10697242": { "compartment": "compartment_7660", "id": "reaction_10697242", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697226", "species_29358" ], "products": [ "species_113582", "species_10697239" ], "modifiers": [ [ "species_10697226", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10696648": { "compartment": "compartment_7660", "id": "reaction_10696648", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696641", "species_113685" ], "products": [ "species_10696645", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10696641", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10696618": { "compartment": "compartment_7660", "id": "reaction_10696618", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696614", "species_10670680" ], "products": [ "species_10696616" ], "modifiers": [], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "DDB_G0290551", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697218": { "compartment": "compartment_7660", "id": "reaction_10697218", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696635", "species_10696614" ], "products": [ "species_10697216" ], "modifiers": [ [ "species_10696616", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697246": { "compartment": "compartment_7660", "id": "reaction_10697246", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676882", "species_10697244" ], "products": [ "species_10697226" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10688018": { "compartment": "compartment_70101", "id": "reaction_10688018", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10684031", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10682708": { "compartment": "compartment_70101", "id": "reaction_10682708", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10682705", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "species_74016", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10695705": { "compartment": "compartment_17957", "id": "reaction_10695705", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046048" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695686": { "compartment": "compartment_12045", "id": "reaction_10695686", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695701": { "compartment": "compartment_12045", "id": "reaction_10695701", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10695703": { "compartment": "compartment_17957", "id": "reaction_10695703", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695707": { "compartment": "compartment_12045", "id": "reaction_10695707", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10695771": { "compartment": "compartment_161320", "id": "reaction_10695771", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10693345": { "compartment": "compartment_17938", "id": "reaction_10693345", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_76194", "species_2090069" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10693855": { "compartment": "compartment_20699", "id": "reaction_10693855", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10693824" ], "products": [ "species_205687", "species_10693831" ], "modifiers": [ [ "species_10693852", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269900", "Q55DR5", "DDB_G0269900", "Q55CU3", "DDB_G0269900" ] }, "reaction_10693373": { "compartment": "compartment_161320", "id": "reaction_10693373", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10695363": { "compartment": "compartment_20699", "id": "reaction_10695363", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695342", "species_741440" ], "products": [ "species_10695349", "species_742343" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695757": { "compartment": "compartment_20699", "id": "reaction_10695757", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695744", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695773": { "compartment": "compartment_161320", "id": "reaction_10695773", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10693365": { "compartment": "compartment_161320", "id": "reaction_10693365", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090033" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10695445": { "compartment": "compartment_17963", "id": "reaction_10695445", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695411" ], "products": [ "species_10695443" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695373": { "compartment": "compartment_20699", "id": "reaction_10695373", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695370", "species_2022884" ], "products": [ "species_10695342", "species_2022890" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695775": { "compartment": "compartment_17938", "id": "reaction_10695775", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090045", "species_76183" ], "products": [ "species_76194", "species_2090053" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10695742": { "compartment": "compartment_17963", "id": "reaction_10695742", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695737", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695375": { "compartment": "compartment_876", "id": "reaction_10695375", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693351" ], "products": [ "species_10692697" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695769": { "compartment": "compartment_161320", "id": "reaction_10695769", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090055", "species_1605715" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10686016": { "compartment": "compartment_70101", "id": "reaction_10686016", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10686011", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10716925": { "compartment": "compartment_20699", "id": "reaction_10716925", "reactome": "R-DDI-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10684974", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10716046": { "compartment": "compartment_20699", "id": "reaction_10716046", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715737", "species_10715128" ], "products": [ "species_10716031" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716035": { "compartment": "compartment_20699", "id": "reaction_10716035", "reactome": "R-DDI-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716031", "species_10715194" ], "products": [ "species_10716033" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716071": { "compartment": "compartment_20699", "id": "reaction_10716071", "reactome": "R-DDI-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716056" ], "products": [ "species_10715128", "species_10715276", "species_10715194", "species_10716068" ], "modifiers": [ [ "species_10716056", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10717044": { "compartment": "compartment_12045", "id": "reaction_10717044", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717040", "species_10717028" ], "products": [ "species_10717042" ], "modifiers": [], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716044": { "compartment": "compartment_20699", "id": "reaction_10716044", "reactome": "R-DDI-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716033" ], "products": [ "species_10716037", "species_29420" ], "modifiers": [ [ "species_10716033", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716093": { "compartment": "compartment_12045", "id": "reaction_10716093", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716090", "species_113592" ], "products": [ "species_10716076", "species_10716081", "species_10681096", "species_10710119", "species_10716086", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10716090", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111", "DDB_G0267646", "DDB_G0281429", "DDB_G0269942", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716214": { "compartment": "compartment_12045", "id": "reaction_10716214", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716212", "species_10710119", "species_10710110" ], "products": [ "species_10716090" ], "modifiers": [], "additional_components": [ "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716058": { "compartment": "compartment_20699", "id": "reaction_10716058", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715775", "species_10715276", "species_10716054", "species_10716039", "species_10716048" ], "products": [ "species_10716056" ], "modifiers": [], "additional_components": [ "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "DDB_G0269942", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716041": { "compartment": "compartment_20699", "id": "reaction_10716041", "reactome": "R-DDI-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716037", "species_10715256" ], "products": [ "species_10716039" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716957": { "compartment": "compartment_20699", "id": "reaction_10716957", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848483", "species_548819" ], "products": [ "species_76194", "species_429785" ], "modifiers": [ [ "species_10716954", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10717053": { "compartment": "compartment_12045", "id": "reaction_10717053", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10717042" ], "products": [ "species_10717050", "species_29420" ], "modifiers": [ [ "species_10717042", "catalyst" ] ], "additional_components": [ "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "species_29438", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716216": { "compartment": "compartment_12045", "id": "reaction_10716216", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716210" ], "products": [ "species_10716168", "species_10716208", "species_10716212", "species_10715256", "species_10710015" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q55CJ0", "DDB_G0270040", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54TZ2", "DDB_G0281429", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q54YZ1", "DDB_G0277997", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q55CA1", "DDB_G0270150", "Q23924", "DDB_G0284735", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10682380": { "compartment": "compartment_70101", "id": "reaction_10682380", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10682377", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10684029": { "compartment": "compartment_17940", "id": "reaction_10684029", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684027" ], "products": [ "species_10684027" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10709972": { "compartment": "compartment_5460", "id": "reaction_10709972", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_159549" ], "products": [ "species_10709961", "species_29376" ], "modifiers": [ [ "species_10709969", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:14949", "Q54JV8", "DDB_G0287773", "Q54KM7", "DDB_G0287255" ] }, "reaction_10709982": { "compartment": "compartment_5460", "id": "reaction_10709982", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709961", "species_200671" ], "products": [ "species_5693984", "species_10709974", "species_5693978" ], "modifiers": [ [ "species_10709979", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q54JV8", "DDB_G0287773", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10709987": { "compartment": "compartment_5460", "id": "reaction_10709987", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709974", "species_113526" ], "products": [ "species_10709957", "species_29362", "species_113529" ], "modifiers": [ [ "species_10709984", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10684177": { "compartment": "compartment_70101", "id": "reaction_10684177", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10684174", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10684192": { "compartment": "compartment_70101", "id": "reaction_10684192", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10684189", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10716937": { "compartment": "compartment_12045", "id": "reaction_10716937", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683793": { "compartment": "compartment_17951", "id": "reaction_10683793", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10716935": { "compartment": "compartment_12045", "id": "reaction_10716935", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10710365": { "compartment": "compartment_12045", "id": "reaction_10710365", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10710362", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683791": { "compartment": "compartment_17951", "id": "reaction_10683791", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10681884": { "compartment": "compartment_70101", "id": "reaction_10681884", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209793", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209934" ], "modifiers": [ [ "species_10681881", "catalyst" ] ], "additional_components": [ "DDB_G0289329" ] }, "reaction_10681900": { "compartment": "compartment_70101", "id": "reaction_10681900", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10681897", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10703615": { "compartment": "compartment_17938", "id": "reaction_10703615", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703600", "species_113592" ], "products": [ "species_29370", "species_10703612" ], "modifiers": [ [ "species_10703600", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725704": { "compartment": "compartment_17947", "id": "reaction_10725704", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725700" ], "products": [ "species_10725702" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704870": { "compartment": "compartment_70101", "id": "reaction_10704870", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704868" ], "products": [ "species_10704836" ], "modifiers": [], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10724968": { "compartment": "compartment_70101", "id": "reaction_10724968", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724940" ], "products": [ "species_10724966" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10722608": { "compartment": "compartment_70101", "id": "reaction_10722608", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722600", "species_10721824" ], "products": [ "species_10722602" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0277699", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699" ] }, "reaction_10704860": { "compartment": "compartment_70101", "id": "reaction_10704860", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10704857", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721818": { "compartment": "compartment_17906", "id": "reaction_10721818", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703459" ], "products": [ "species_10721816" ], "modifiers": [], "additional_components": [ "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10722606": { "compartment": "compartment_21994", "id": "reaction_10722606", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722602", "species_10701260" ], "products": [ "species_10722604" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q75K07", "DDB_G0277699" ] }, "reaction_10721827": { "compartment": "compartment_17906", "id": "reaction_10721827", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_29370", "species_10721824" ], "modifiers": [ [ "species_10721816", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10703635": { "compartment": "compartment_17938", "id": "reaction_10703635", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10724956": { "compartment": "compartment_70101", "id": "reaction_10724956", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724954" ], "products": [ "species_10724952", "species_10724944" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725708": { "compartment": "compartment_70101", "id": "reaction_10725708", "reactome": "R-DDI-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725652" ], "products": [ "species_10725677" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10725712": { "compartment": "compartment_70101", "id": "reaction_10725712", "reactome": "R-DDI-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725659", "species_10725669" ], "products": [ "species_10725671" ], "modifiers": [], "additional_components": [ "DDB_G0270098", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10724932": { "compartment": "compartment_70101", "id": "reaction_10724932", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689017", "species_10724928" ], "products": [ "species_10724930" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704855": { "compartment": "compartment_70101", "id": "reaction_10704855", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704836" ], "products": [ "species_29370", "species_10703627" ], "modifiers": [ [ "species_10704852", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10703630": { "compartment": "compartment_12045", "id": "reaction_10703630", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10703627", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10704806": { "compartment": "compartment_70101", "id": "reaction_10704806", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704781", "species_5681998" ], "products": [ "species_10704783", "species_10704785" ], "modifiers": [ [ "species_10704803", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "DDB_G0277319", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10725698": { "compartment": "compartment_17947", "id": "reaction_10725698", "reactome": "R-DDI-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725661", "species_10725677" ], "products": [ "species_10725679" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703598": { "compartment": "compartment_70101", "id": "reaction_10703598", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703495" ], "products": [ "species_29370", "species_10703595" ], "modifiers": [ [ "species_10703495", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704672": { "compartment": "compartment_74700", "id": "reaction_10704672", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704214" ], "products": [ "species_10677585", "species_10703610" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10703639": { "compartment": "compartment_70101", "id": "reaction_10703639", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_10703473" ], "products": [ "species_10703600" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725696": { "compartment": "compartment_17947", "id": "reaction_10725696", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725692" ], "products": [ "species_10725694" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0284133", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q86CR8", "DDB_G0286191" ] }, "reaction_10721810": { "compartment": "compartment_70101", "id": "reaction_10721810", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_10721808", "species_29370" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10704947": { "compartment": "compartment_70101", "id": "reaction_10704947", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704916" ], "products": [ "species_10704773" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10725687": { "compartment": "compartment_17947", "id": "reaction_10725687", "reactome": "R-DDI-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725679" ], "products": [ "species_10725685" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705356": { "compartment": "compartment_70101", "id": "reaction_10705356", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703610" ], "products": [ "species_10703473", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10704862": { "compartment": "compartment_70101", "id": "reaction_10704862", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704681" ], "products": [ "species_10704852" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10723993": { "compartment": "compartment_70101", "id": "reaction_10723993", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704874" ], "products": [ "species_10705267" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10724970": { "compartment": "compartment_70101", "id": "reaction_10724970", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724966" ], "products": [ "species_10724954" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704216": { "compartment": "compartment_70101", "id": "reaction_10704216", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703612" ], "products": [ "species_29370", "species_10704214" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10704876": { "compartment": "compartment_70101", "id": "reaction_10704876", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704792" ], "products": [ "species_10704874" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10705132": { "compartment": "compartment_70101", "id": "reaction_10705132", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10704773", "species_5681998" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10704949": { "compartment": "compartment_70101", "id": "reaction_10704949", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704773" ], "products": [ "species_10704883" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191" ] }, "reaction_10725706": { "compartment": "compartment_17947", "id": "reaction_10725706", "reactome": "R-DDI-9664881", "name": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725671", "species_10725692" ], "products": [ "species_10725700" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "DDB_G0284133", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704704": { "compartment": "compartment_70101", "id": "reaction_10704704", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704700", "species_5693050" ], "products": [ "species_10704702" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54SA0", "DDB_G0282581", "Q54NA2", "DDB_G0285375", "species_1806159", "Q54SA0", "DDB_G0282581" ] }, "reaction_10705183": { "compartment": "compartment_5683628", "id": "reaction_10705183", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10705174" ], "modifiers": [ [ "species_10705181", "catalyst" ], [ "species_10687292", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "P54676", "DDB_G0289601", "Q54JC5", "DDB_G0288175", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087" ] }, "reaction_10704864": { "compartment": "compartment_70101", "id": "reaction_10704864", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704801", "species_10704799" ], "products": [ "species_10704803" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10705335": { "compartment": "compartment_70101", "id": "reaction_10705335", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704887" ], "products": [ "species_10704872", "species_10704781" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10725710": { "compartment": "compartment_17947", "id": "reaction_10725710", "reactome": "R-DDI-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725685" ], "products": [ "species_10725669" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703498": { "compartment": "compartment_70101", "id": "reaction_10703498", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703475", "species_113592" ], "products": [ "species_29370", "species_10703495" ], "modifiers": [ [ "species_10703475", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10725654": { "compartment": "compartment_70101", "id": "reaction_10725654", "reactome": "R-DDI-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724145", "species_10725650" ], "products": [ "species_10725652" ], "modifiers": [], "additional_components": [ "DDB_G0286033", "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705269": { "compartment": "compartment_70101", "id": "reaction_10705269", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704883", "species_10704785" ], "products": [ "species_10704885" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10724942": { "compartment": "compartment_70101", "id": "reaction_10724942", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724938", "species_10724930" ], "products": [ "species_10724940" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725675": { "compartment": "compartment_17947", "id": "reaction_10725675", "reactome": "R-DDI-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725671" ], "products": [ "species_10725673" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10705145": { "compartment": "compartment_12045", "id": "reaction_10705145", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703627" ], "products": [ "species_10705136" ], "modifiers": [ [ "species_10705141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "DDB_G0285323" ] }, "reaction_10703617": { "compartment": "compartment_70101", "id": "reaction_10703617", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703473", "species_10683107" ], "products": [ "species_10703475" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704890": { "compartment": "compartment_70101", "id": "reaction_10704890", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704885" ], "products": [ "species_10704887" ], "modifiers": [ [ "species_10704885", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10704684": { "compartment": "compartment_70101", "id": "reaction_10704684", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703595" ], "products": [ "species_29370", "species_10704681" ], "modifiers": [ [ "species_10703595", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10714394": { "compartment": "compartment_70101", "id": "reaction_10714394", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10714372" ], "products": [ "species_71285", "species_10714379" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10709680": { "compartment": "compartment_70101", "id": "reaction_10709680", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10709677", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10725743": { "compartment": "compartment_70101", "id": "reaction_10725743", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683047", "species_113592", "species_29356" ], "products": [ "species_10683043", "species_29370", "species_29372" ], "modifiers": [ [ "species_10725732", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725738": { "compartment": "compartment_13231", "id": "reaction_10725738", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725728", "species_10725722" ], "products": [ "species_10725730" ], "modifiers": [], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "DDB_G0283793", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725736": { "compartment": "compartment_70101", "id": "reaction_10725736", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687703", "species_10725732" ], "products": [ "species_10725734" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54PT2", "DDB_G0284347", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724709": { "compartment": "compartment_1598585", "id": "reaction_10724709", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681066" ], "products": [ "species_10724701", "species_29420" ], "modifiers": [ [ "species_10724706", "catalyst" ] ], "additional_components": [ "species_29420", "P33519", "DDB_G0291235", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10698508": { "compartment": "compartment_13231", "id": "reaction_10698508", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698490" ], "products": [ "species_10698305", "species_10698505" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54N16", "DDB_G0285563", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10724716": { "compartment": "compartment_70101", "id": "reaction_10724716", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724711", "species_29356" ], "products": [ "species_10681066", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10698505", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "species_29420", "P33519", "DDB_G0291235", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10725740": { "compartment": "compartment_70101", "id": "reaction_10725740", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725717", "species_10725730" ], "products": [ "species_10725732" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724713": { "compartment": "compartment_70101", "id": "reaction_10724713", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10724701" ], "products": [ "species_10724711" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10670890": { "compartment": "compartment_70101", "id": "reaction_10670890", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10670880": { "compartment": "compartment_70101", "id": "reaction_10670880", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10670877", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10716376": { "compartment": "compartment_70101", "id": "reaction_10716376", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10670900": { "compartment": "compartment_70101", "id": "reaction_10670900", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10670897", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10702192": { "compartment": "compartment_7660", "id": "reaction_10702192", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_10702188", "species_10702174" ], "products": [ "species_10702190" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702289": { "compartment": "compartment_7660", "id": "reaction_10702289", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702167", "species_10702172" ], "products": [ "species_10702174" ], "modifiers": [], "additional_components": [ "DDB_G0287393", "DDB_G0283981", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393" ] }, "reaction_10702208": { "compartment": "compartment_7660", "id": "reaction_10702208", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702190" ], "products": [ "species_10702205" ], "modifiers": [ [ "species_10702190", "catalyst" ] ], "additional_components": [ "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702287": { "compartment": "compartment_7660", "id": "reaction_10702287", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702184" ], "products": [ "species_10702210" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0268614", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702227": { "compartment": "compartment_7660", "id": "reaction_10702227", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702212", "species_29358" ], "products": [ "species_113582", "species_10702188" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702285": { "compartment": "compartment_7660", "id": "reaction_10702285", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702197" ], "products": [ "species_10702199" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0281683", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702203": { "compartment": "compartment_7660", "id": "reaction_10702203", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10702199" ], "products": [ "species_10702201" ], "modifiers": [], "additional_components": [ "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702216": { "compartment": "compartment_7660", "id": "reaction_10702216", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10702214": { "compartment": "compartment_7660", "id": "reaction_10702214", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702210", "species_5358514" ], "products": [ "species_10702212" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702225": { "compartment": "compartment_7660", "id": "reaction_10702225", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702221", "species_10702205" ], "products": [ "species_10702223" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10675582": { "compartment": "compartment_7660", "id": "reaction_10675582", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675580", "species_10675574" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0289199", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10675587": { "compartment": "compartment_7660", "id": "reaction_10675587", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10675584" ], "products": [ "species_113582", "species_10675580" ], "modifiers": [ [ "species_10675584", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10676478": { "compartment": "compartment_7660", "id": "reaction_10676478", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675584" ], "products": [ "species_10675584" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10675602": { "compartment": "compartment_7660", "id": "reaction_10675602", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675592", "species_10675576", "species_10675598" ], "products": [ "species_10675600" ], "modifiers": [], "additional_components": [ "DDB_G0278479", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0287661", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675578": { "compartment": "compartment_7660", "id": "reaction_10675578", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675576" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10670593": { "compartment": "compartment_7660", "id": "reaction_10670593", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670586" ], "products": [ "species_10670590" ], "modifiers": [ [ "species_10670584", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609" ] }, "reaction_10670597": { "compartment": "compartment_7660", "id": "reaction_10670597", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670590" ], "products": [ "species_10670595" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670617": { "compartment": "compartment_7660", "id": "reaction_10670617", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10670609": { "compartment": "compartment_7660", "id": "reaction_10670609", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670599" ], "products": [ "species_10670601" ], "modifiers": [ [ "species_10670606", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "DDB_G0284987" ] }, "reaction_10688208": { "compartment": "compartment_20699", "id": "reaction_10688208", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688218": { "compartment": "compartment_20699", "id": "reaction_10688218", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688220": { "compartment": "compartment_20699", "id": "reaction_10688220", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688216": { "compartment": "compartment_20699", "id": "reaction_10688216", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10688213", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10686090": { "compartment": "compartment_70101", "id": "reaction_10686090", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686088" ], "products": [], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0275027", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10686077": { "compartment": "compartment_70101", "id": "reaction_10686077", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686071", "species_450444" ], "products": [ "species_10686075" ], "modifiers": [], "additional_components": [ "Q86I71", "DDB_G0275027", "Q86I71", "DDB_G0275027" ] }, "reaction_10686313": { "compartment": "compartment_876", "id": "reaction_10686313", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686265" ], "products": [ "species_10686311" ], "modifiers": [], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758" ] }, "reaction_10686448": { "compartment": "compartment_876", "id": "reaction_10686448", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686424" ], "products": [ "species_10686446" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569" ] }, "reaction_10682506": { "compartment": "compartment_161320", "id": "reaction_10682506", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682498" ], "products": [ "species_10682504" ], "modifiers": [], "additional_components": [ "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417", "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417" ] }, "reaction_10686372": { "compartment": "compartment_876", "id": "reaction_10686372", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686352" ], "products": [ "species_10686370" ], "modifiers": [], "additional_components": [ "P04988", "DDB_G0290957", "species_74016", "species_29370", "CHEBI:15996", "species_111349", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436", "P04988", "DDB_G0290957", "species_74016", "species_29370", "species_29438", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29420", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436" ] }, "reaction_10686484": { "compartment": "compartment_876", "id": "reaction_10686484", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686472" ], "products": [ "species_10686482" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10686628": { "compartment": "compartment_70101", "id": "reaction_10686628", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686552" ], "products": [ "species_10686626" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507" ] }, "reaction_10701635": { "compartment": "compartment_70101", "id": "reaction_10701635", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701632", "species_113592" ], "products": [ "species_10679174", "species_29370", "species_10678454", "species_5218688" ], "modifiers": [ [ "species_10701626", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_428193", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0284545" ] }, "reaction_10725915": { "compartment": "compartment_70101", "id": "reaction_10725915", "reactome": "R-DDI-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725899" ], "products": [ "species_10725913" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10725936": { "compartment": "compartment_7660", "id": "reaction_10725936", "reactome": "R-DDI-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10725931" ], "products": [ "species_10725913", "species_427486" ], "modifiers": [ [ "species_10725933", "catalyst" ] ], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q55FN5", "DDB_G0268024", "Q55BW2", "DDB_G0270338" ] }, "reaction_10677104": { "compartment": "compartment_70101", "id": "reaction_10677104", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10677101", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10675817": { "compartment": "compartment_70101", "id": "reaction_10675817", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10675791" ], "products": [ "species_29370", "species_10675814" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10680170": { "compartment": "compartment_70101", "id": "reaction_10680170", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680149" ], "products": [ "species_29370", "species_10680079" ], "modifiers": [ [ "species_10680163", "catalyst" ], [ "species_10680168", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10697254": { "compartment": "compartment_876", "id": "reaction_10697254", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680079", "species_10675800" ], "products": [ "species_10680081" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10697252": { "compartment": "compartment_70101", "id": "reaction_10697252", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10725901": { "compartment": "compartment_70101", "id": "reaction_10725901", "reactome": "R-DDI-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725897" ], "products": [ "species_10725899" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10674483": { "compartment": "compartment_17940", "id": "reaction_10674483", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10690303": { "compartment": "compartment_70101", "id": "reaction_10690303", "reactome": "R-DDI-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10690293" ], "products": [ "species_29370", "species_10690301" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10680102": { "compartment": "compartment_70101", "id": "reaction_10680102", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680081", "species_113592" ], "products": [ "species_29370", "species_10680099", "species_10675800" ], "modifiers": [ [ "species_10680081", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10675793": { "compartment": "compartment_876", "id": "reaction_10675793", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675789" ], "products": [ "species_10675775", "species_10675791" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10714853": { "compartment": "compartment_7660", "id": "reaction_10714853", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672464", "species_10672420", "species_10714849" ], "products": [ "species_10714851" ], "modifiers": [], "additional_components": [ "DDB_G0284321", "DDB_G0280393", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54PW8", "DDB_G0284321", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54VI2", "DDB_G0280393" ] }, "reaction_10675802": { "compartment": "compartment_876", "id": "reaction_10675802", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675798" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10693751": { "compartment": "compartment_70101", "id": "reaction_10693751", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693634": { "compartment": "compartment_70101", "id": "reaction_10693634", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693551": { "compartment": "compartment_70101", "id": "reaction_10693551", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693631": { "compartment": "compartment_70101", "id": "reaction_10693631", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693543": { "compartment": "compartment_70101", "id": "reaction_10693543", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693711": { "compartment": "compartment_70101", "id": "reaction_10693711", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_994149", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693620": { "compartment": "compartment_70101", "id": "reaction_10693620", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10693617", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10693742": { "compartment": "compartment_70101", "id": "reaction_10693742", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10690279": { "compartment": "compartment_876", "id": "reaction_10690279", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690276", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690258": { "compartment": "compartment_876", "id": "reaction_10690258", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690255", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690146": { "compartment": "compartment_876", "id": "reaction_10690146", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690143", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10690247": { "compartment": "compartment_876", "id": "reaction_10690247", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690244", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690159": { "compartment": "compartment_876", "id": "reaction_10690159", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690156", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10690197": { "compartment": "compartment_876", "id": "reaction_10690197", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690194", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255" ] }, "reaction_10690226": { "compartment": "compartment_876", "id": "reaction_10690226", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690223", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10678283": { "compartment": "compartment_876", "id": "reaction_10678283", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678272", "species_10678254" ], "products": [ "species_10678274" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10684258": { "compartment": "compartment_876", "id": "reaction_10684258", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682952", "species_352003" ], "products": [ "species_10682954" ], "modifiers": [], "additional_components": [ "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_916850", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356" ] }, "reaction_10678281": { "compartment": "compartment_876", "id": "reaction_10678281", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_10678278", "species_29372" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678307": { "compartment": "compartment_876", "id": "reaction_10678307", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_29372", "species_10678292" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678294": { "compartment": "compartment_876", "id": "reaction_10678294", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678292" ], "products": [ "species_10676221", "species_10678276", "species_10678290" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10672907": { "compartment": "compartment_7660", "id": "reaction_10672907", "reactome": "R-DDI-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672894", "species_10672779", "species_10672899", "species_10672884", "species_10672879", "species_10672889", "species_10672874" ], "products": [ "species_10672755", "species_10672287", "species_10672241", "species_10672598", "species_10672340", "species_10672335", "species_10672760", "species_10672345", "species_10672905" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q54WN2", "DDB_G0279535", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54HF6", "DDB_G0289499", "Q55FQ0", "DDB_G0268004", "Q9NI62", "DDB_G0269216", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54BG2", "DDB_G0293636", "Q55EC6", "DDB_G0269300", "Q54R72", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672931", "species_10676865" ], "products": [ "species_10672949" ], "modifiers": [], "additional_components": [ "Q55E21", "DDB_G0270866", "Q54ME8", "DDB_G0286007", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54WZ0", "DDB_G0279311", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q1ZXF6", "DDB_G0284555", "Q54DH7", "DDB_G0292244", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "Q55E21", "DDB_G0270866", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q54WZ0", "DDB_G0279311", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q55AR8", "DDB_G0271788", "Q54J75", "DDB_G0288257", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54NJ4", "DDB_G0285213", "Q54CT3", "DDB_G0292778", "P35084", "DDB_G0279193", "Q54WP9", "DDB_G0279507", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54ME8", "DDB_G0286007", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q86A14", "DDB_G0272676", "Q54ZS8", "DDB_G0277371", "Q55BL6", "DDB_G0270450", "Q54CN1", "DDB_G0292846", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54GS9", "DDB_G0289933", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q54R66", "DDB_G0283365", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "C7G084", "DDB_G0295793", "Q54PX3", "DDB_G0291966", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10672912": { "compartment": "compartment_7660", "id": "reaction_10672912", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672905" ], "products": [ "species_10672909", "species_10672899" ], "modifiers": [ [ "species_10672905", "catalyst" ] ], "additional_components": [ "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "DDB_G0268358", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10683372": { "compartment": "compartment_12045", "id": "reaction_10683372", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683362" ], "products": [ "species_10683370" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10683430": { "compartment": "compartment_876", "id": "reaction_10683430", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683426", "species_30389" ], "products": [ "species_10683428" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683348": { "compartment": "compartment_876", "id": "reaction_10683348", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10683344" ], "products": [ "species_10683346" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683434": { "compartment": "compartment_70101", "id": "reaction_10683434", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10683432" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10683428", "catalyst" ], [ "species_10683346", "catalyst" ] ], "additional_components": [ "species_111349", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10679921": { "compartment": "compartment_12045", "id": "reaction_10679921", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10725767": { "compartment": "compartment_984", "id": "reaction_10725767", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9673044", "species_109276" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10725765": { "compartment": "compartment_984", "id": "reaction_10725765", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_9673044", "species_109276" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10686978": { "compartment": "compartment_70101", "id": "reaction_10686978", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686974", "species_10686972" ], "products": [ "species_10686976" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10686985": { "compartment": "compartment_876", "id": "reaction_10686985", "reactome": "R-DDI-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10686982", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10690134": { "compartment": "compartment_70101", "id": "reaction_10690134", "reactome": "R-DDI-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690130", "species_10673826" ], "products": [ "species_10690132" ], "modifiers": [], "additional_components": [ "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "Q86KB1", "DDB_G0274395", "Q54HT7", "DDB_G0289229", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "P29447", "DDB_G0294489", "Q86KB1", "DDB_G0274395", "Q1ZXE0", "DDB_G0287849", "Q54HT7", "DDB_G0289229" ] }, "reaction_10690136": { "compartment": "compartment_70101", "id": "reaction_10690136", "reactome": "R-DDI-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673826", "species_1250243" ], "products": [ "species_10673820" ], "modifiers": [], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849" ] }, "reaction_10684160": { "compartment": "compartment_876", "id": "reaction_10684160", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10684157", "catalyst" ] ], "additional_components": [ "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473" ] }, "reaction_10711700": { "compartment": "compartment_7660", "id": "reaction_10711700", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711648" ], "products": [ "species_10711656" ], "modifiers": [ [ "species_10711697", "catalyst" ], [ "species_10711680", "catalyst" ], [ "species_10711695", "catalyst" ], [ "species_10711661", "catalyst" ] ], "additional_components": [ "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q86IE2", "DDB_G0275633", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55AW0", "DDB_G0271572", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54ZS3", "DDB_G0277279", "Q54N99", "DDB_G0285377", "DDB_G0284053", "DDB_G0275633", "DDB_G0271572" ] }, "reaction_10711868": { "compartment": "compartment_70101", "id": "reaction_10711868", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711840", "species_10711842" ], "products": [ "species_10711850", "species_10711856", "species_10711854", "species_10673208", "species_10711848", "species_10711846", "species_10711860", "species_10711852", "species_10711844", "species_10711842", "species_10711858" ], "modifiers": [ [ "species_10711848", "catalyst" ], [ "species_10711860", "catalyst" ], [ "species_10711866", "catalyst" ], [ "species_10711858", "catalyst" ] ], "additional_components": [ "Q54K66", "DDB_G0287557", "Q54GC0", "DDB_G0290281", "Q76P36", "DDB_G0272308", "Q54W91", "DDB_G0279821", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q54T05", "DDB_G0282099", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q8T1D4", "DDB_G0275601", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q3ZE13", "DDB_G0269980", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54IS0", "DDB_G0288565", "P46793", "DDB_G0276457", "Q556Y4", "DDB_G0273059", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "Q54U04", "DDB_G0281409", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54VD8", "DDB_G0280431", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "O77082", "DDB_G0286117", "Q54YA7", "DDB_G0278331", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54W23", "DDB_G0279961", "Q54I41", "DDB_G0289025", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0280431", "DDB_G0287557", "DDB_G0280431", "DDB_G0278331", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0282099", "DDB_G0288565", "DDB_G0280431", "DDB_G0273059", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10711424": { "compartment": "compartment_7660", "id": "reaction_10711424", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711408" ], "products": [ "species_10711387" ], "modifiers": [ [ "species_10711383", "catalyst" ], [ "species_10711406", "catalyst" ], [ "species_10711378", "catalyst" ], [ "species_10711422", "catalyst" ] ], "additional_components": [ "Q54TD8", "DDB_G0281839", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54W52", "DDB_G0279903", "Q54IM3", "DDB_G0288659", "Q54HJ2", "DDB_G0289415", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54IM3", "DDB_G0288659", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "DDB_G0277945", "Q54TD8", "DDB_G0281839", "Q54W52", "DDB_G0279903", "Q54HJ2", "DDB_G0289415", "DDB_G0272176", "Q54P34", "DDB_G0284817", "Q54KS4", "DDB_G0287147", "Q54HJ2", "DDB_G0289415" ] }, "reaction_10683571": { "compartment": "compartment_17951", "id": "reaction_10683571", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10683568", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10716318": { "compartment": "compartment_70101", "id": "reaction_10716318", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680089", "species_29356" ], "products": [ "species_10683769", "species_29372" ], "modifiers": [ [ "species_10716315", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10692828": { "compartment": "compartment_876", "id": "reaction_10692828", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692825", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693245": { "compartment": "compartment_876", "id": "reaction_10693245", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10725879": { "compartment": "compartment_876", "id": "reaction_10725879", "reactome": "R-DDI-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530" ], "products": [ "species_10725877" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10723407": { "compartment": "compartment_876", "id": "reaction_10723407", "reactome": "R-DDI-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723395" ], "products": [ "species_10723405" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049" ] }, "reaction_10723412": { "compartment": "compartment_876", "id": "reaction_10723412", "reactome": "R-DDI-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723395" ], "products": [ "species_10683530", "species_29420" ], "modifiers": [ [ "species_10723409", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "Q54F64", "DDB_G0291085", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q54B37", "DDB_G0293978", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10723417": { "compartment": "compartment_876", "id": "reaction_10723417", "reactome": "R-DDI-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530", "species_29356" ], "products": [ "species_10723395", "species_29372" ], "modifiers": [ [ "species_10723414", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10709853": { "compartment": "compartment_7660", "id": "reaction_10709853", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709849", "species_10709820" ], "products": [ "species_10709824" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709818": { "compartment": "compartment_7660", "id": "reaction_10709818", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706016", "species_10706025", "species_10706023", "species_10709816" ], "products": [ "species_10706029" ], "modifiers": [], "additional_components": [ "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709827": { "compartment": "compartment_7660", "id": "reaction_10709827", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709824" ], "products": [ "species_113582", "species_10705998" ], "modifiers": [ [ "species_10709824", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10706007": { "compartment": "compartment_7660", "id": "reaction_10706007", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10706000" ], "products": [ "species_113582", "species_10706004" ], "modifiers": [ [ "species_10706000", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709842": { "compartment": "compartment_7660", "id": "reaction_10709842", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709792" ], "products": [ "species_10709816" ], "modifiers": [ [ "species_10709839", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q556S0", "DDB_G0273125", "Q55DD6", "DDB_G0269692" ] }, "reaction_10706034": { "compartment": "compartment_7660", "id": "reaction_10706034", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10706029" ], "products": [ "species_113541", "species_10706031" ], "modifiers": [ [ "species_10706029", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709795": { "compartment": "compartment_7660", "id": "reaction_10709795", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706004" ], "products": [ "species_10709792" ], "modifiers": [ [ "species_10706004", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10695511": { "compartment": "compartment_70101", "id": "reaction_10695511", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10695509" ], "products": [ "species_29370", "species_10683624", "species_10685605" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10695587": { "compartment": "compartment_70101", "id": "reaction_10695587", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693765", "species_10695583" ], "products": [ "species_10695585" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102" ] }, "reaction_10696677": { "compartment": "compartment_70101", "id": "reaction_10696677", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695585" ], "products": [ "species_10695631", "species_10695581" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "species_179838", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519" ] }, "reaction_10695513": { "compartment": "compartment_70101", "id": "reaction_10695513", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683631" ], "products": [ "species_10683629", "species_10695509" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10695633": { "compartment": "compartment_70101", "id": "reaction_10695633", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680919", "species_10695631" ], "products": [ "species_10693810" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q553U6", "DDB_G0275023", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102" ] }, "reaction_10721256": { "compartment": "compartment_70101", "id": "reaction_10721256", "reactome": "R-DDI-8932243", "name": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676998", "species_71284" ], "products": [ "species_71285", "species_10721248" ], "modifiers": [ [ "species_10721253", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0277003" ] }, "reaction_10721245": { "compartment": "compartment_7660", "id": "reaction_10721245", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10672551" ], "products": [ "species_10721237", "species_77502" ], "modifiers": [ [ "species_10721242", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10721301": { "compartment": "compartment_70101", "id": "reaction_10721301", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_10721293", "species_71285" ], "modifiers": [ [ "species_10721298", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0278427" ] }, "reaction_10721279": { "compartment": "compartment_70101", "id": "reaction_10721279", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_71284" ], "products": [ "species_10721267", "species_71285" ], "modifiers": [ [ "species_10721276", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10721214": { "compartment": "compartment_70101", "id": "reaction_10721214", "reactome": "R-DDI-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10673088" ], "products": [ "species_71285", "species_10721209" ], "modifiers": [ [ "species_10721211", "catalyst" ] ], "additional_components": [ "DDB_G0293742", "DDB_G0293742", "DDB_G0291556" ] }, "reaction_10721234": { "compartment": "compartment_70101", "id": "reaction_10721234", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_71285", "species_10721226" ], "modifiers": [ [ "species_10721231", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10679876": { "compartment": "compartment_70101", "id": "reaction_10679876", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644", "species_29368" ], "products": [ "species_29366", "species_194735", "species_29356" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679891": { "compartment": "compartment_13231", "id": "reaction_10679891", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194688", "species_194725" ], "products": [ "species_194704", "species_194668" ], "modifiers": [ [ "species_10679888", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10679622": { "compartment": "compartment_70101", "id": "reaction_10679622", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_191265", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679843": { "compartment": "compartment_17951", "id": "reaction_10679843", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10725944": { "compartment": "compartment_70101", "id": "reaction_10725944", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10718908": { "compartment": "compartment_70101", "id": "reaction_10718908", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10718905", "catalyst" ] ], "additional_components": [ "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q54QP6", "DDB_G0283709", "Q54ID7", "DDB_G0288817", "Q86HV4", "DDB_G0276427" ] }, "reaction_10679883": { "compartment": "compartment_70101", "id": "reaction_10679883", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194723", "species_29368" ], "products": [ "species_29366", "species_29356", "species_194657" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679552": { "compartment": "compartment_70101", "id": "reaction_10679552", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191269", "species_29368" ], "products": [ "species_29366", "species_191309", "species_29356" ], "modifiers": [ [ "species_10679549", "catalyst" ] ], "additional_components": [ "Q54BK7", "DDB_G0293584", "species_113596" ] }, "reaction_10679863": { "compartment": "compartment_70101", "id": "reaction_10679863", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679729": { "compartment": "compartment_70101", "id": "reaction_10679729", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192114", "species_29360" ], "products": [ "species_70106", "species_73473", "species_192136" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679632": { "compartment": "compartment_70101", "id": "reaction_10679632", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10679629", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10679834": { "compartment": "compartment_876", "id": "reaction_10679834", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193416", "species_113592", "species_29356" ], "products": [ "species_29370", "species_193479", "species_29372" ], "modifiers": [ [ "species_10679831", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10714962": { "compartment": "compartment_12045", "id": "reaction_10714962", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10679836": { "compartment": "compartment_17951", "id": "reaction_10679836", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679590": { "compartment": "compartment_70101", "id": "reaction_10679590", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10679587", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10679881": { "compartment": "compartment_70101", "id": "reaction_10679881", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_73473", "species_113528", "species_194667" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679839": { "compartment": "compartment_17951", "id": "reaction_10679839", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10679600": { "compartment": "compartment_70101", "id": "reaction_10679600", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10679597", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10679620": { "compartment": "compartment_70101", "id": "reaction_10679620", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_191265", "species_29364" ], "products": [ "species_29366", "species_191269", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679749": { "compartment": "compartment_17951", "id": "reaction_10679749", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679714": { "compartment": "compartment_70101", "id": "reaction_10679714", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10679711", "catalyst" ] ], "additional_components": [ "Q55D54", "DDB_G0279611", "Q55D52", "DDB_G0279611", "species_71067", "Q54WK0", "DDB_G0279611" ] }, "reaction_10681907": { "compartment": "compartment_70101", "id": "reaction_10681907", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10681904", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10679564": { "compartment": "compartment_70101", "id": "reaction_10679564", "reactome": "R-DDI-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679913": { "compartment": "compartment_70101", "id": "reaction_10679913", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_194657" ], "products": [ "species_73473", "species_70106", "species_194661", "species_113528" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679784": { "compartment": "compartment_70101", "id": "reaction_10679784", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_176626" ], "products": [ "species_70106", "species_73473", "species_193079" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679582": { "compartment": "compartment_70101", "id": "reaction_10679582", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10679579", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10686933": { "compartment": "compartment_70101", "id": "reaction_10686933", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193066" ], "products": [ "species_29366", "species_193132" ], "modifiers": [ [ "species_10686930", "catalyst" ] ], "additional_components": [ "Q54WA9", "DDB_G0279783" ] }, "reaction_10679739": { "compartment": "compartment_17951", "id": "reaction_10679739", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10701893": { "compartment": "compartment_17957", "id": "reaction_10701893", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10701890", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10679567": { "compartment": "compartment_70101", "id": "reaction_10679567", "reactome": "R-DDI-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679871": { "compartment": "compartment_876", "id": "reaction_10679871", "reactome": "R-DDI-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "DDB_G0285165" ] }, "reaction_10679770": { "compartment": "compartment_70101", "id": "reaction_10679770", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10726092": { "compartment": "compartment_70101", "id": "reaction_10726092", "reactome": "R-DDI-9717830", "name": "GGPS1 hexamer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679782": { "compartment": "compartment_70101", "id": "reaction_10679782", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10679779", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10679928": { "compartment": "compartment_70101", "id": "reaction_10679928", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196366" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679841": { "compartment": "compartment_17951", "id": "reaction_10679841", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10726095": { "compartment": "compartment_70101", "id": "reaction_10726095", "reactome": "R-DDI-9717834", "name": "GGPS1 hexamer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679861": { "compartment": "compartment_70101", "id": "reaction_10679861", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192194", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193835" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679911": { "compartment": "compartment_70101", "id": "reaction_10679911", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644" ], "products": [ "species_29366", "species_194633" ], "modifiers": [ [ "species_10679908", "catalyst" ] ], "additional_components": [ "Q54PP1", "DDB_G0284407", "Q55GJ9", "DDB_G0267448" ] }, "reaction_10679572": { "compartment": "compartment_70101", "id": "reaction_10679572", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10679569", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10679610": { "compartment": "compartment_70101", "id": "reaction_10679610", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10679607", "catalyst" ] ], "additional_components": [ "species_29926", "Q9NH02", "DDB_G0290011" ] }, "reaction_10679899": { "compartment": "compartment_70101", "id": "reaction_10679899", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634", "species_29368" ], "products": [ "species_29366", "species_194644", "species_29460", "species_29356" ], "modifiers": [ [ "species_10679896", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10722153": { "compartment": "compartment_70101", "id": "reaction_10722153", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10722150", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10679926": { "compartment": "compartment_70101", "id": "reaction_10679926", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196344" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679859": { "compartment": "compartment_70101", "id": "reaction_10679859", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193724" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10673670": { "compartment": "compartment_70101", "id": "reaction_10673670", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673388" ], "products": [ "species_10673296", "species_10673386", "species_29420" ], "modifiers": [ [ "species_10673386", "catalyst" ] ], "additional_components": [ "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961" ] }, "reaction_10673390": { "compartment": "compartment_70101", "id": "reaction_10673390", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673338", "species_10673386" ], "products": [ "species_10673388" ], "modifiers": [], "additional_components": [ "species_29420", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862" ] }, "reaction_10712164": { "compartment": "compartment_7660", "id": "reaction_10712164", "reactome": "R-DDI-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712158" ], "products": [ "species_113582", "species_10712162" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0293750", "DDB_G0293750", "DDB_G0275845" ] }, "reaction_10714907": { "compartment": "compartment_7660", "id": "reaction_10714907", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714903", "species_10676372" ], "products": [ "species_10714905" ], "modifiers": [], "additional_components": [ "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54G78", "DDB_G0290331" ] }, "reaction_10700599": { "compartment": "compartment_7660", "id": "reaction_10700599", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698368", "species_10700571" ], "products": [ "species_10698305", "species_10700596" ], "modifiers": [ [ "species_10698368", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0268098", "DDB_G0287693", "DDB_G0268098", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700587": { "compartment": "compartment_7660", "id": "reaction_10700587", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700571" ], "products": [ "species_10698305", "species_10700585" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268098", "DDB_G0287693", "Q55FI4", "DDB_G0268098", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676662": { "compartment": "compartment_114521", "id": "reaction_10676662", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676659", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10676758": { "compartment": "compartment_876", "id": "reaction_10676758", "reactome": "R-DDI-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676755", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10692427": { "compartment": "compartment_161320", "id": "reaction_10692427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692508": { "compartment": "compartment_876", "id": "reaction_10692508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10692505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10692400": { "compartment": "compartment_161320", "id": "reaction_10692400", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10692397", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10693818": { "compartment": "compartment_876", "id": "reaction_10693818", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10693815", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10692360": { "compartment": "compartment_161320", "id": "reaction_10692360", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692425": { "compartment": "compartment_161320", "id": "reaction_10692425", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10692422", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10692437": { "compartment": "compartment_876", "id": "reaction_10692437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29356" ], "products": [ "species_1861754", "species_1606609" ], "modifiers": [ [ "species_10692434", "catalyst" ] ], "additional_components": [ "Q54BK2", "DDB_G0293538" ] }, "reaction_10692417": { "compartment": "compartment_161320", "id": "reaction_10692417", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10692414", "catalyst" ] ], "additional_components": [ "Q55B10", "DDB_G0271490", "Q54EG4", "DDB_G0291524" ] }, "reaction_10702402": { "compartment": "compartment_876", "id": "reaction_10702402", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684166", "species_10684155" ], "products": [ "species_10702400" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q55CT1", "DDB_G0269912", "Q54PE8", "DDB_G0289473", "Q54L96", "DDB_G0286763" ] }, "reaction_10688485": { "compartment": "compartment_74700", "id": "reaction_10688485", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688478", "species_10685814" ], "products": [ "species_10688480" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688006": { "compartment": "compartment_70101", "id": "reaction_10688006", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687994", "species_10685814" ], "products": [ "species_10687996" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688483": { "compartment": "compartment_74700", "id": "reaction_10688483", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10688480" ], "products": [ "species_10686011" ], "modifiers": [ [ "species_10688480", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10678168": { "compartment": "compartment_984", "id": "reaction_10678168", "reactome": "R-DDI-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678162", "species_168948" ], "products": [ "species_10678166" ], "modifiers": [], "additional_components": [ "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628", "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628" ] }, "reaction_10719248": { "compartment": "compartment_984", "id": "reaction_10719248", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10677632" ], "products": [ "species_10719246" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_2186967" ] }, "reaction_10688009": { "compartment": "compartment_70101", "id": "reaction_10688009", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10688001", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10677638": { "compartment": "compartment_984", "id": "reaction_10677638", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677632", "species_166005" ], "products": [ "species_10677634" ], "modifiers": [ [ "species_10677636", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_6803081", "DDB_G0271242" ] }, "reaction_10714923": { "compartment": "compartment_984", "id": "reaction_10714923", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340" ], "products": [ "species_10714865" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10688004": { "compartment": "compartment_876", "id": "reaction_10688004", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10687996" ], "products": [ "species_10688001" ], "modifiers": [ [ "species_10687996", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10714873": { "compartment": "compartment_984", "id": "reaction_10714873", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_166005" ], "products": [ "species_10714871" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_6803081" ] }, "reaction_10714869": { "compartment": "compartment_984", "id": "reaction_10714869", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_181015" ], "products": [ "species_10714867" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10704731": { "compartment": "compartment_70101", "id": "reaction_10704731", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10704728", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10726173": { "compartment": "compartment_70101", "id": "reaction_10726173", "reactome": "R-DDI-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10726170", "catalyst" ] ], "additional_components": [ "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10726136": { "compartment": "compartment_70101", "id": "reaction_10726136", "reactome": "R-DDI-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726125": { "compartment": "compartment_70101", "id": "reaction_10726125", "reactome": "R-DDI-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10726122", "catalyst" ] ], "additional_components": [ "P32073", "DDB_G0281551" ] }, "reaction_10726134": { "compartment": "compartment_70101", "id": "reaction_10726134", "reactome": "R-DDI-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10678993", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10726163": { "compartment": "compartment_70101", "id": "reaction_10726163", "reactome": "R-DDI-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726129": { "compartment": "compartment_70101", "id": "reaction_10726129", "reactome": "R-DDI-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726118": { "compartment": "compartment_70101", "id": "reaction_10726118", "reactome": "R-DDI-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10674001", "catalyst" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701" ] }, "reaction_10726127": { "compartment": "compartment_70101", "id": "reaction_10726127", "reactome": "R-DDI-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10726131": { "compartment": "compartment_70101", "id": "reaction_10726131", "reactome": "R-DDI-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10726120": { "compartment": "compartment_70101", "id": "reaction_10726120", "reactome": "R-DDI-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10678801": { "compartment": "compartment_7660", "id": "reaction_10678801", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647" ], "products": [ "species_10678645", "species_10678597" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259" ] }, "reaction_10678652": { "compartment": "compartment_7660", "id": "reaction_10678652", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647", "species_10669917" ], "products": [ "species_10678649" ], "modifiers": [ [ "species_10678647", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678780": { "compartment": "compartment_70101", "id": "reaction_10678780", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678775" ], "products": [ "species_10678777" ], "modifiers": [ [ "species_10676850", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q8T2F2", "DDB_G0277439", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678754": { "compartment": "compartment_7660", "id": "reaction_10678754", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678741": { "compartment": "compartment_7660", "id": "reaction_10678741", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678649" ], "products": [ "species_10678645", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678784": { "compartment": "compartment_70101", "id": "reaction_10678784", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678782" ], "products": [ "species_10670153", "species_10670512" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679249": { "compartment": "compartment_7660", "id": "reaction_10679249", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10679167": { "compartment": "compartment_70101", "id": "reaction_10679167", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10679160" ], "products": [ "species_10679164" ], "modifiers": [ [ "species_10679160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676858": { "compartment": "compartment_70101", "id": "reaction_10676858", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676836", "species_10676831", "species_10676841", "species_10676846" ], "products": [ "species_10676848" ], "modifiers": [], "additional_components": [ "DDB_G0292134", "DDB_G0292676", "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10679169": { "compartment": "compartment_70101", "id": "reaction_10679169", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679164" ], "products": [ "species_10670153", "species_10676850" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678858": { "compartment": "compartment_70101", "id": "reaction_10678858", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678844" ], "products": [ "species_10678856", "species_10670153", "species_10678838" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54MZ3", "DDB_G0285601", "Q54KM3", "DDB_G0287259", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678769": { "compartment": "compartment_70101", "id": "reaction_10678769", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670512", "species_10678765" ], "products": [ "species_10678767" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q86HN7", "DDB_G0274503", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678852": { "compartment": "compartment_70101", "id": "reaction_10678852", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678767" ], "products": [ "species_10678782" ], "modifiers": [ [ "species_10678767", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678854": { "compartment": "compartment_70101", "id": "reaction_10678854", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678809" ], "products": [ "species_10670153", "species_10678797" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679162": { "compartment": "compartment_70101", "id": "reaction_10679162", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850", "species_10679158" ], "products": [ "species_10679160" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0270814", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676852": { "compartment": "compartment_70101", "id": "reaction_10676852", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676848", "species_10670505" ], "products": [ "species_10676850" ], "modifiers": [], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678862": { "compartment": "compartment_70101", "id": "reaction_10678862", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679243" ], "products": [ "species_10678747", "species_10670680", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0290551", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678812": { "compartment": "compartment_70101", "id": "reaction_10678812", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678805" ], "products": [ "species_10678809" ], "modifiers": [ [ "species_10678797", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676856": { "compartment": "compartment_70101", "id": "reaction_10676856", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676841", "species_10676846" ], "products": [ "species_10676854" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201" ] }, "reaction_10678868": { "compartment": "compartment_70101", "id": "reaction_10678868", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850" ], "products": [ "species_10678797", "species_10678866" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10725854": { "compartment": "compartment_7660", "id": "reaction_10725854", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725851", "species_10669917" ], "products": [ "species_10679243" ], "modifiers": [ [ "species_10725851", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678795": { "compartment": "compartment_7660", "id": "reaction_10678795", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678645" ], "products": [ "species_10678645" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0274503" ] }, "reaction_10678847": { "compartment": "compartment_70101", "id": "reaction_10678847", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678842" ], "products": [ "species_10678844" ], "modifiers": [ [ "species_10678838", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10693242": { "compartment": "compartment_172574", "id": "reaction_10693242", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691994": { "compartment": "compartment_12045", "id": "reaction_10691994", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10691991", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54WR4", "DDB_G0279483" ] }, "reaction_10691844": { "compartment": "compartment_12045", "id": "reaction_10691844", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10691841", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691704": { "compartment": "compartment_12045", "id": "reaction_10691704", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10716710": { "compartment": "compartment_876", "id": "reaction_10716710", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10716707", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10691923": { "compartment": "compartment_12045", "id": "reaction_10691923", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10691920", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10691709": { "compartment": "compartment_12045", "id": "reaction_10691709", "reactome": "R-DDI-1482696", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691773": { "compartment": "compartment_12045", "id": "reaction_10691773", "reactome": "R-DDI-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691770", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693140": { "compartment": "compartment_876", "id": "reaction_10693140", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10710251": { "compartment": "compartment_876", "id": "reaction_10710251", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10710248", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10693123": { "compartment": "compartment_171062", "id": "reaction_10693123", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693332": { "compartment": "compartment_20699", "id": "reaction_10693332", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10693329", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10693135": { "compartment": "compartment_876", "id": "reaction_10693135", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10693132", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927" ] }, "reaction_10691817": { "compartment": "compartment_12045", "id": "reaction_10691817", "reactome": "R-DDI-1482920", "name": "PG is hydrolyzed to 2-acyl LPG by PLA2[14]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498730", "species_1524021" ], "modifiers": [ [ "species_10691814", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691802": { "compartment": "compartment_12045", "id": "reaction_10691802", "reactome": "R-DDI-1482892", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691812": { "compartment": "compartment_12045", "id": "reaction_10691812", "reactome": "R-DDI-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498740", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691805": { "compartment": "compartment_70616", "id": "reaction_10691805", "reactome": "R-DDI-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1498773", "species_1524083" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691683": { "compartment": "compartment_12045", "id": "reaction_10691683", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10691907": { "compartment": "compartment_70101", "id": "reaction_10691907", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10691904", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10693310": { "compartment": "compartment_20699", "id": "reaction_10693310", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10693137": { "compartment": "compartment_20699", "id": "reaction_10693137", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693277": { "compartment": "compartment_20699", "id": "reaction_10693277", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10717024": { "compartment": "compartment_70101", "id": "reaction_10717024", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10717021", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_1806205", "species_6810408", "species_1806159", "Q54FY6", "DDB_G0290653", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630" ] }, "reaction_10716932": { "compartment": "compartment_12045", "id": "reaction_10716932", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10716927", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10691872": { "compartment": "compartment_20699", "id": "reaction_10691872", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10691869", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691789": { "compartment": "compartment_12045", "id": "reaction_10691789", "reactome": "R-DDI-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693250": { "compartment": "compartment_171062", "id": "reaction_10693250", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10710279": { "compartment": "compartment_70101", "id": "reaction_10710279", "reactome": "R-DDI-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10710276", "catalyst" ] ], "additional_components": [ "Q54QE7", "DDB_G0291476", "Q54EK1", "DDB_G0291476" ] }, "reaction_10691810": { "compartment": "compartment_12045", "id": "reaction_10691810", "reactome": "R-DDI-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10691807", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691822": { "compartment": "compartment_12045", "id": "reaction_10691822", "reactome": "R-DDI-1482932", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498737", "species_1524021" ], "modifiers": [ [ "species_10691819", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10674942": { "compartment": "compartment_12045", "id": "reaction_10674942", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10674939", "catalyst" ] ], "additional_components": [ "Q54EU4", "DDB_G0291332", "Q54IG1", "DDB_G0288863", "Q554U0", "DDB_G0274969", "Q54IT8", "DDB_G0288523" ] }, "reaction_10691795": { "compartment": "compartment_12045", "id": "reaction_10691795", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691755", "catalyst" ] ], "additional_components": [ "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691697": { "compartment": "compartment_12045", "id": "reaction_10691697", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691999": { "compartment": "compartment_12045", "id": "reaction_10691999", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10691996", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10715867": { "compartment": "compartment_70101", "id": "reaction_10715867", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693218", "species_10715851" ], "products": [ "species_10715865" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693285": { "compartment": "compartment_20699", "id": "reaction_10693285", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10692026": { "compartment": "compartment_20699", "id": "reaction_10692026", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691932" ], "products": [ "species_10692024" ], "modifiers": [], "additional_components": [ "species_426925", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10691650": { "compartment": "compartment_12045", "id": "reaction_10691650", "reactome": "R-DDI-1482571", "name": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693112": { "compartment": "compartment_20699", "id": "reaction_10693112", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10693109", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10691800": { "compartment": "compartment_12045", "id": "reaction_10691800", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10691797", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10693081": { "compartment": "compartment_20699", "id": "reaction_10693081", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10693078", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691743": { "compartment": "compartment_70616", "id": "reaction_10691743", "reactome": "R-DDI-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524079", "species_1524072" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691957": { "compartment": "compartment_70616", "id": "reaction_10691957", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10691954", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10692991": { "compartment": "compartment_20699", "id": "reaction_10692991", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10692988", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10691692": { "compartment": "compartment_12045", "id": "reaction_10691692", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692777": { "compartment": "compartment_876", "id": "reaction_10692777", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691648": { "compartment": "compartment_17906", "id": "reaction_10691648", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10691645", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10691934": { "compartment": "compartment_20699", "id": "reaction_10691934", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10691930" ], "products": [ "species_1524146", "species_10691932" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10686815": { "compartment": "compartment_12045", "id": "reaction_10686815", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10674935", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10693288": { "compartment": "compartment_876", "id": "reaction_10693288", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691685": { "compartment": "compartment_12045", "id": "reaction_10691685", "reactome": "R-DDI-1482629", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715945": { "compartment": "compartment_70101", "id": "reaction_10715945", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693303": { "compartment": "compartment_20699", "id": "reaction_10693303", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693076", "species_10693301" ], "products": [ "species_10693078" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "DDB_G0286479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691776": { "compartment": "compartment_70616", "id": "reaction_10691776", "reactome": "R-DDI-1482847", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524047" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691707": { "compartment": "compartment_12045", "id": "reaction_10691707", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10718992": { "compartment": "compartment_12045", "id": "reaction_10718992", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10718989", "catalyst" ] ], "additional_components": [ "Q54RM1", "DDB_G0283035", "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q86HV4", "DDB_G0276427" ] }, "reaction_10691655": { "compartment": "compartment_12045", "id": "reaction_10691655", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10722413": { "compartment": "compartment_17906", "id": "reaction_10722413", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10722410", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10691666": { "compartment": "compartment_17906", "id": "reaction_10691666", "reactome": "R-DDI-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590", "species_29356" ], "products": [ "species_1524103", "species_1500580" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715912": { "compartment": "compartment_171062", "id": "reaction_10715912", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10715903", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691680": { "compartment": "compartment_12045", "id": "reaction_10691680", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715948": { "compartment": "compartment_70101", "id": "reaction_10715948", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691792": { "compartment": "compartment_12045", "id": "reaction_10691792", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710324": { "compartment": "compartment_17906", "id": "reaction_10710324", "reactome": "R-DDI-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10710321", "catalyst" ] ], "additional_components": [ "species_6797635", "species_6814795", "species_1602448", "species_417891", "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "species_29926", "Q54HN2", "DDB_G0289343" ] }, "reaction_10692978": { "compartment": "compartment_876", "id": "reaction_10692978", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10715905": { "compartment": "compartment_70101", "id": "reaction_10715905", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692890", "species_10715901" ], "products": [ "species_10715903" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721170": { "compartment": "compartment_5460", "id": "reaction_10721170", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10721167", "catalyst" ] ], "additional_components": [ "DDB_G0284755" ] }, "reaction_10691765": { "compartment": "compartment_12045", "id": "reaction_10691765", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691762", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710368": { "compartment": "compartment_12045", "id": "reaction_10710368", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680333": { "compartment": "compartment_70101", "id": "reaction_10680333", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691952": { "compartment": "compartment_12045", "id": "reaction_10691952", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10691949", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10691882": { "compartment": "compartment_12045", "id": "reaction_10691882", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10691879", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29418", "species_29926" ] }, "reaction_10685601": { "compartment": "compartment_984", "id": "reaction_10685601", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10685598", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10711099": { "compartment": "compartment_70101", "id": "reaction_10711099", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10711096", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q55DN9", "DDB_G0276935" ] }, "reaction_10691727": { "compartment": "compartment_70616", "id": "reaction_10691727", "reactome": "R-DDI-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1524085", "species_1498753" ], "modifiers": [ [ "species_10691724", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693335": { "compartment": "compartment_171062", "id": "reaction_10693335", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10693095", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693308": { "compartment": "compartment_876", "id": "reaction_10693308", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10693305", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10693296": { "compartment": "compartment_876", "id": "reaction_10693296", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693293", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693282": { "compartment": "compartment_12045", "id": "reaction_10693282", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10693279", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10693291": { "compartment": "compartment_171062", "id": "reaction_10693291", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691965": { "compartment": "compartment_12045", "id": "reaction_10691965", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_71284" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10691962", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10722158": { "compartment": "compartment_984", "id": "reaction_10722158", "reactome": "R-DDI-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10722155", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10693313": { "compartment": "compartment_876", "id": "reaction_10693313", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691699": { "compartment": "compartment_70101", "id": "reaction_10691699", "reactome": "R-DDI-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691732": { "compartment": "compartment_12045", "id": "reaction_10691732", "reactome": "R-DDI-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498724", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10720416": { "compartment": "compartment_876", "id": "reaction_10720416", "reactome": "R-DDI-8870489", "name": "PLEKHA4,(5,6) bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720412", "species_1806276" ], "products": [ "species_10720414" ], "modifiers": [], "additional_components": [ "Q54Z52", "DDB_G0277777", "Q54Z52", "DDB_G0277777", "species_1806159" ] }, "reaction_10693003": { "compartment": "compartment_876", "id": "reaction_10693003", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10719120": { "compartment": "compartment_70101", "id": "reaction_10719120", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10719117", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q55DN9", "DDB_G0276935" ] }, "reaction_10693228": { "compartment": "compartment_876", "id": "reaction_10693228", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691640": { "compartment": "compartment_12045", "id": "reaction_10691640", "reactome": "R-DDI-1482545", "name": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715942": { "compartment": "compartment_70101", "id": "reaction_10715942", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715938" ], "products": [ "species_10715940" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10682763": { "compartment": "compartment_984", "id": "reaction_10682763", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10682758", "catalyst" ], [ "species_10682761", "inhibitor" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10693239": { "compartment": "compartment_876", "id": "reaction_10693239", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10693236", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10702080": { "compartment": "compartment_876", "id": "reaction_10702080", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702076", "species_171142" ], "products": [ "species_10702078" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q86K21", "DDB_G0272875", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791", "Q86K21", "DDB_G0272875", "species_171142", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791" ] }, "reaction_10715875": { "compartment": "compartment_876", "id": "reaction_10715875", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10715909": { "compartment": "compartment_70101", "id": "reaction_10715909", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715901" ], "products": [ "species_10715907" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693299": { "compartment": "compartment_876", "id": "reaction_10693299", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691942": { "compartment": "compartment_12045", "id": "reaction_10691942", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_200736" ], "products": [ "species_1500646", "species_1498751" ], "modifiers": [ [ "species_10691939", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10692973": { "compartment": "compartment_172574", "id": "reaction_10692973", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691720": { "compartment": "compartment_70616", "id": "reaction_10691720", "reactome": "R-DDI-1482745", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524027" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10715855": { "compartment": "compartment_70101", "id": "reaction_10715855", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715851", "species_10715825" ], "products": [ "species_10715853" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691635": { "compartment": "compartment_12045", "id": "reaction_10691635", "reactome": "R-DDI-1482543", "name": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_29356" ], "products": [ "species_76116", "species_1500593" ], "modifiers": [ [ "species_10691632", "catalyst" ] ], "additional_components": [ "Q55EQ3", "DDB_G0269086" ] }, "reaction_10721177": { "compartment": "compartment_984", "id": "reaction_10721177", "reactome": "R-DDI-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878780", "species_109276" ], "products": [ "species_109277", "species_8878776" ], "modifiers": [ [ "species_10721174", "catalyst" ] ], "additional_components": [ "species_29426", "species_74016", "Q54Y02", "DDB_G0278495" ] }, "reaction_10691702": { "compartment": "compartment_12045", "id": "reaction_10691702", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692986": { "compartment": "compartment_12045", "id": "reaction_10692986", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10692049": { "compartment": "compartment_12045", "id": "reaction_10692049", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692028" ], "products": [ "species_10691930" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10693269": { "compartment": "compartment_876", "id": "reaction_10693269", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693266", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "species_29418", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10715872": { "compartment": "compartment_876", "id": "reaction_10715872", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693230": { "compartment": "compartment_172574", "id": "reaction_10693230", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10718631": { "compartment": "compartment_984", "id": "reaction_10718631", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_83910", "species_8865629" ], "modifiers": [ [ "species_10718628", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10679264": { "compartment": "compartment_5460", "id": "reaction_10679264", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10679261", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10697686": { "compartment": "compartment_1598585", "id": "reaction_10697686", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10697678", "species_10697638" ], "products": [ "species_10697684" ], "modifiers": [], "additional_components": [ "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54S35", "DDB_G0282689", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q54RK7", "DDB_G0283099", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101" ] }, "reaction_10724623": { "compartment": "compartment_984", "id": "reaction_10724623", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10709857", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q54ET7", "DDB_G0291344" ] }, "reaction_10675685": { "compartment": "compartment_7660", "id": "reaction_10675685", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675681", "species_10675662" ], "products": [ "species_10675683" ], "modifiers": [], "additional_components": [ "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10675664": { "compartment": "compartment_7660", "id": "reaction_10675664", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675660" ], "products": [ "species_10675662" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10675689": { "compartment": "compartment_7660", "id": "reaction_10675689", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675683" ], "products": [ "species_10675681", "species_10675687" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10682234": { "compartment": "compartment_70101", "id": "reaction_10682234", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10682231", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10696143": { "compartment": "compartment_70101", "id": "reaction_10696143", "reactome": "R-DDI-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10696140", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "species_29450" ] }, "reaction_10679144": { "compartment": "compartment_5460", "id": "reaction_10679144", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_177153", "species_113593" ], "products": [ "species_159448", "species_177137", "species_159450" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677098": { "compartment": "compartment_5460", "id": "reaction_10677098", "reactome": "R-DDI-159567", "name": "ACSM2B-like proteins transform ST to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159559", "species_113593" ], "products": [ "species_159448", "species_159557", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677081": { "compartment": "compartment_5460", "id": "reaction_10677081", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159446", "species_113593" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10723456": { "compartment": "compartment_70101", "id": "reaction_10723456", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723452", "species_10676533" ], "products": [ "species_10723454" ], "modifiers": [], "additional_components": [ "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q869N2", "DDB_G0276459" ] }, "reaction_10703564": { "compartment": "compartment_876", "id": "reaction_10703564", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703557" ], "products": [ "species_10703559" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10726069": { "compartment": "compartment_876", "id": "reaction_10726069", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726067" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10726063": { "compartment": "compartment_876", "id": "reaction_10726063", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726050" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10703562": { "compartment": "compartment_70101", "id": "reaction_10703562", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703559", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10723450": { "compartment": "compartment_70101", "id": "reaction_10723450", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723366", "species_10723444" ], "products": [ "species_10723448" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723813": { "compartment": "compartment_876", "id": "reaction_10723813", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723796", "species_10723809" ], "products": [ "species_10723811" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q55CB3", "DDB_G0290593", "Q86KL1", "DDB_G0274241", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q54LT3", "DDB_G0286425", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q54FU0", "DDB_G0290593", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q54B82", "DDB_G0293844", "P34144", "DDB_G0277869", "P34146", "DDB_G0282365", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q86KL1", "DDB_G0274241", "species_29438", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "Q54HL6", "DDB_G0289361", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593" ] }, "reaction_10723162": { "compartment": "compartment_876", "id": "reaction_10723162", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10723159", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54PB7", "DDB_G0292004", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54DS6", "DDB_G0291974", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q55BQ8", "DDB_G0292004", "Q54S15", "DDB_G0293396", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q54DW1", "DDB_G0292004", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10725982": { "compartment": "compartment_263163", "id": "reaction_10725982", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725978", "species_10725976" ], "products": [ "species_10725980" ], "modifiers": [], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q8T2F2", "DDB_G0277439", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "P36411", "DDB_G0269236", "Q1ZXI1", "DDB_G0279085", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54NZ5", "DDB_G0284903", "Q54FK7", "DDB_G0290779", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "Q54FK8", "DDB_G0290829", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q1ZXB9", "DDB_G0290831", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "P34145", "DDB_G0268622", "Q1ZXI1", "DDB_G0279085", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P34146", "DDB_G0282365", "Q8T2F2", "DDB_G0277439", "Q54K69", "DDB_G0287553", "Q9GPR7", "DDB_G0269240", "Q54FK2", "DDB_G0290793", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q54FK5", "DDB_G0290789", "species_113592", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975" ] }, "reaction_10723744": { "compartment": "compartment_876", "id": "reaction_10723744", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723740", "species_10723682" ], "products": [ "species_10723742" ], "modifiers": [], "additional_components": [ "Q55CB2", "DDB_G0290593", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q54P92", "DDB_G0284699", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "Q54TA6", "DDB_G0281889", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q54P92", "DDB_G0284699", "P34150", "DDB_G0291976", "Q8MPQ7", "DDB_G0280053", "Q54N82", "DDB_G0285453", "Q86HL8", "DDB_G0274517", "P34145", "DDB_G0268622", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "P34146", "DDB_G0282365", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q54TA6", "DDB_G0281889", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "P34149", "DDB_G0293526", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459" ] }, "reaction_10723589": { "compartment": "compartment_876", "id": "reaction_10723589", "reactome": "R-DDI-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723581" ], "products": [ "species_10723579", "species_29420" ], "modifiers": [ [ "species_10689591", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084" ] }, "reaction_10702646": { "compartment": "compartment_876", "id": "reaction_10702646", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10680761" ], "products": [ "species_10702641" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10725989": { "compartment": "compartment_263163", "id": "reaction_10725989", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725976", "species_29356" ], "products": [ "species_10725986", "species_29372" ], "modifiers": [ [ "species_10725976", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "species_29370", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10726061": { "compartment": "compartment_17906", "id": "reaction_10726061", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726050", "species_10726057" ], "products": [ "species_10726059" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55DS3", "DDB_G0269550", "Q55DS3", "DDB_G0269550", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10702637": { "compartment": "compartment_70101", "id": "reaction_10702637", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10702633" ], "products": [ "species_10702635" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723890": { "compartment": "compartment_876", "id": "reaction_10723890", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723880" ], "products": [ "species_10723878", "species_29372" ], "modifiers": [ [ "species_10723887", "catalyst" ] ], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "species_29420", "P34147", "DDB_G0286555", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q8I7P3", "DDB_G0267462", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10723688": { "compartment": "compartment_876", "id": "reaction_10723688", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723680", "species_29438" ], "products": [ "species_10723682" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723759": { "compartment": "compartment_876", "id": "reaction_10723759", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723748", "species_10723755" ], "products": [ "species_10723757" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "species_29438", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10712144": { "compartment": "compartment_1222693", "id": "reaction_10712144", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10712141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10722712": { "compartment": "compartment_70101", "id": "reaction_10722712", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683656" ], "products": [ "species_10683654", "species_10702660" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10726075": { "compartment": "compartment_876", "id": "reaction_10726075", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723880" ], "products": [ "species_10726073" ], "modifiers": [], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10723466": { "compartment": "compartment_70101", "id": "reaction_10723466", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723444" ], "products": [ "species_10676533", "species_29420" ], "modifiers": [ [ "species_10723463", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084", "Q54LN3", "DDB_G0286543", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10674723": { "compartment": "compartment_70101", "id": "reaction_10674723", "reactome": "R-DDI-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674719", "species_10674690" ], "products": [ "species_10674721" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "DDB_G0283617", "P54632", "DDB_G0269138", "Q54QM6", "DDB_G0283617" ] }, "reaction_10723374": { "compartment": "compartment_876", "id": "reaction_10723374", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723370", "species_10695507" ], "products": [ "species_10723372" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "P34144", "DDB_G0277869", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34144", "DDB_G0277869" ] }, "reaction_10723874": { "compartment": "compartment_876", "id": "reaction_10723874", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723872" ], "products": [ "species_10723864", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10703581": { "compartment": "compartment_70101", "id": "reaction_10703581", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703572" ], "products": [ "species_29370", "species_10703578" ], "modifiers": [ [ "species_10702680", "catalyst" ] ], "additional_components": [ "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10703534": { "compartment": "compartment_876", "id": "reaction_10703534", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703530" ], "products": [ "species_10703532" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10725984": { "compartment": "compartment_263163", "id": "reaction_10725984", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10725974" ], "products": [ "species_10725976" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10723906": { "compartment": "compartment_876", "id": "reaction_10723906", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723902", "species_10723880" ], "products": [ "species_10723904" ], "modifiers": [], "additional_components": [ "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "P34147", "DDB_G0286555", "species_29438", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "P34147", "DDB_G0286555", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "species_29438", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10723586": { "compartment": "compartment_876", "id": "reaction_10723586", "reactome": "R-DDI-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723579", "species_29356" ], "products": [ "species_10723581", "species_29372" ], "modifiers": [ [ "species_10723583", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q8I7P3", "DDB_G0267462", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10726106": { "compartment": "compartment_876", "id": "reaction_10726106", "reactome": "R-DDI-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726100" ], "products": [ "species_10726104" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723461": { "compartment": "compartment_70101", "id": "reaction_10723461", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533", "species_29356" ], "products": [ "species_10723444", "species_29372" ], "modifiers": [ [ "species_10723458", "catalyst" ] ], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q9GPQ8", "DDB_G0292816", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723354": { "compartment": "compartment_876", "id": "reaction_10723354", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10723350" ], "products": [ "species_10723352" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "species_29438", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10702689": { "compartment": "compartment_70101", "id": "reaction_10702689", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702662", "species_113592" ], "products": [ "species_29370", "species_10683624", "species_10702686" ], "modifiers": [ [ "species_10702662", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723870": { "compartment": "compartment_876", "id": "reaction_10723870", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723864", "species_10723866" ], "products": [ "species_10723868" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "species_29438", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459" ] }, "reaction_10702643": { "compartment": "compartment_70101", "id": "reaction_10702643", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10693765" ], "products": [ "species_10702639" ], "modifiers": [ [ "species_10702641", "inhibitor" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q54K32", "DDB_G0287585", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "species_29438", "O00899", "DDB_G0269140", "Q54HF1", "DDB_G0289505", "Q9GPS0", "DDB_G0269178", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "P34144", "DDB_G0277869", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723898": { "compartment": "compartment_876", "id": "reaction_10723898", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_10723892" ], "products": [ "species_10723896" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "Q95UQ1", "DDB_G0291077", "species_29420", "Q95UQ1", "DDB_G0291077", "P34147", "DDB_G0286555" ] }, "reaction_10723798": { "compartment": "compartment_74700", "id": "reaction_10723798", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723794" ], "products": [ "species_10723796" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10703537": { "compartment": "compartment_70101", "id": "reaction_10703537", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703532", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10723885": { "compartment": "compartment_876", "id": "reaction_10723885", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_29438" ], "products": [ "species_10723880", "species_29420" ], "modifiers": [ [ "species_10723882", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084" ] }, "reaction_10723290": { "compartment": "compartment_876", "id": "reaction_10723290", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_29356" ], "products": [ "species_29372", "species_10695507" ], "modifiers": [ [ "species_10723287", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54FG5", "DDB_G0290873", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10725875": { "compartment": "compartment_876", "id": "reaction_10725875", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526" ], "products": [ "species_10725873" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10722714": { "compartment": "compartment_70101", "id": "reaction_10722714", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683652" ], "products": [ "species_10683650", "species_10702658" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723764": { "compartment": "compartment_876", "id": "reaction_10723764", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723761" ], "products": [ "species_10723748", "species_29420" ], "modifiers": [ [ "species_10723761", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723468": { "compartment": "compartment_876", "id": "reaction_10723468", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10703511" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723686": { "compartment": "compartment_876", "id": "reaction_10723686", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723682" ], "products": [ "species_10723684" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q95UQ1", "DDB_G0291077", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "Q95UP9", "DDB_G0280049", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723860": { "compartment": "compartment_74700", "id": "reaction_10723860", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723845", "species_10723856" ], "products": [ "species_10723858" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54Y26", "DDB_G0278457", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q869T1", "DDB_G0274437", "Q54HF1", "DDB_G0289505", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P34146", "DDB_G0282365", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q869T1", "DDB_G0274437", "P34148", "DDB_G0279605", "Q54HF1", "DDB_G0289505", "P34149", "DDB_G0293526", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530" ] }, "reaction_10682167": { "compartment": "compartment_13231", "id": "reaction_10682167", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682163" ], "products": [ "species_10682165" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10682358": { "compartment": "compartment_7660", "id": "reaction_10682358", "reactome": "R-DDI-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10682348" ], "products": [ "species_113582", "species_10682163" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0288453", "DDB_G0288453", "DDB_G0275845" ] }, "reaction_10682172": { "compartment": "compartment_70101", "id": "reaction_10682172", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10682165" ], "products": [ "species_10682169" ], "modifiers": [ [ "species_10682165", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453" ] }, "reaction_10682174": { "compartment": "compartment_70101", "id": "reaction_10682174", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682169" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10684699": { "compartment": "compartment_7660", "id": "reaction_10684699", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684682", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10682100" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10684702": { "compartment": "compartment_7660", "id": "reaction_10684702", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10682100" ], "products": [ "species_10674676", "species_77502" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10689258": { "compartment": "compartment_70101", "id": "reaction_10689258", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689251" ], "products": [ "species_10689255", "species_10689247", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689128", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54YW2", "DDB_G0278049", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q54FX4", "DDB_G0290547", "Q550Z9", "DDB_G0276695", "Q54LZ6", "DDB_G0286289", "Q94490", "DDB_G0284865", "Q55EJ5", "DDB_G0270000", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54XF1", "DDB_G0279003", "Q54L05", "DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", 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"DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q557I6", "DDB_G0273399", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q75JS0", "DDB_G0272202", "Q557E7", "DDB_G0273141", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249" ] }, "reaction_10689274": { "compartment": "compartment_70101", "id": "reaction_10689274", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10670153", "species_983032", "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689362": { "compartment": "compartment_70101", "id": "reaction_10689362", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10689359", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10721580": { "compartment": "compartment_70101", "id": "reaction_10721580", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10721577", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10681335": { "compartment": "compartment_12045", "id": "reaction_10681335", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681331" ], "products": [ "species_10681333" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29438", "Q559R0", "DDB_G0272296" ] }, "reaction_10689306": { "compartment": "compartment_70101", "id": "reaction_10689306", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_29926", "species_10689298" ], "products": [ "species_10689300", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10689298", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047" ] }, "reaction_10689303": { "compartment": "compartment_70101", "id": "reaction_10689303", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689300", "species_10689247" ], "products": [ "species_10689249", "species_10689298" ], "modifiers": [ [ "species_10689247", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345" ] }, "reaction_10689341": { "compartment": "compartment_17957", "id": "reaction_10689341", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10689338", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10689309": { "compartment": "compartment_70101", "id": "reaction_10689309", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689255", "species_113592" ], "products": [ "species_10689247", "species_10689270", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689255", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689128", "species_983035" ], "products": [ "species_10689251" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", 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"DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54E43", "DDB_G0291812", "Q54TE1", "DDB_G0290629", "Q54JT8", "DDB_G0292128", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q55C16", "DDB_G0270272", "Q557I6", "DDB_G0273399", "Q54D06", "DDB_G0292596", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "P0CG80", "DDB_G0291928", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "Q75JS0", "DDB_G0272202", "P14794", "DDB_G0280755", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q553F3", "DDB_G0275787", "Q557Q0", "DDB_G0291812", "Q75JE1", "DDB_G0288345", "Q54XF7", "DDB_G0278991", "Q54TL7", "DDB_G0281679", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54JV0", "DDB_G0292128", "Q54I43", "DDB_G0289021", "Q54I29", "DDB_G0292642", "Q54IK3", "DDB_G0290547", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54RP0", "DDB_G0283005", "Q54VG3", "DDB_G0280347", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q54VW9", "DDB_G0280091", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "P0CG79", "DDB_G0282369", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54U33", "DDB_G0281369", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "P0CG77", "DDB_G0286907", "Q55EY8", "DDB_G0268938", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q54TK0", "DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q555G0", "DDB_G0274897", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q54J27", "DDB_G0288345" ] }, "reaction_10689272": { "compartment": "compartment_70101", "id": "reaction_10689272", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689270" ], "products": [ "species_983123", "species_10689128" ], "modifiers": [], "additional_components": [ "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10722775": { "compartment": "compartment_876", "id": "reaction_10722775", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722754" ], "products": [ "species_10722772", "species_29372" ], "modifiers": [ [ "species_10722754", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684253": { "compartment": "compartment_876", "id": "reaction_10684253", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141" ], "products": [ "species_10684218" ], "modifiers": [ [ "species_10676141", "catalyst" ], [ "species_10684251", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10676760": { "compartment": "compartment_70101", "id": "reaction_10676760", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676657", "species_114520" ], "products": [ "species_10676659" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10684674": { "compartment": "compartment_70101", "id": "reaction_10684674", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10684665", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10722756": { "compartment": "compartment_876", "id": "reaction_10722756", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_10722752" ], "products": [ "species_10722754" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684660": { "compartment": "compartment_70101", "id": "reaction_10684660", "reactome": "R-DDI-426043", "name": "2-AG hydrolysis to arachidonate by MAGL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426030", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10684657", "catalyst" ] ], "additional_components": [ "DDB_G0269086" ] }, "reaction_10722777": { "compartment": "compartment_876", "id": "reaction_10722777", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722772" ], "products": [ "species_10722752", "species_10684218" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10684652": { "compartment": "compartment_876", "id": "reaction_10684652", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10684649", "catalyst" ] ], "additional_components": [ "Q54YL1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54ET1", "DDB_G0291354" ] }, "reaction_10676646": { "compartment": "compartment_876", "id": "reaction_10676646", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676641" ], "products": [ "species_10676643" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "species_179856", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_114520", "P34044", "DDB_G0283151", "species_6797635", "species_29438", "Q02158", "DDB_G0292736", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10673792": { "compartment": "compartment_70101", "id": "reaction_10673792", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673796": { "compartment": "compartment_70101", "id": "reaction_10673796", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10674384": { "compartment": "compartment_70101", "id": "reaction_10674384", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q54PM8", "DDB_G0284431" ] }, "reaction_10673794": { "compartment": "compartment_70101", "id": "reaction_10673794", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10673760": { "compartment": "compartment_70101", "id": "reaction_10673760", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10673740": { "compartment": "compartment_70101", "id": "reaction_10673740", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673750": { "compartment": "compartment_70101", "id": "reaction_10673750", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10675646": { "compartment": "compartment_5460", "id": "reaction_10675646", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10722311": { "compartment": "compartment_5460", "id": "reaction_10722311", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10722308", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10679923": { "compartment": "compartment_876", "id": "reaction_10679923", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679514", "species_10679534" ], "products": [ "species_10679536" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q94464", "DDB_G0277849", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487" ] }, "reaction_10669451": { "compartment": "compartment_7660", "id": "reaction_10669451", "reactome": "R-DDI-68595", "name": "ORC2 binds ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669447", "species_10669442" ], "products": [ "species_10669449" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10669460": { "compartment": "compartment_7660", "id": "reaction_10669460", "reactome": "R-DDI-68603", "name": "ORC5 binds ORC2:ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669449", "species_10669456" ], "products": [ "species_10669458" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078" ] }, "reaction_10726116": { "compartment": "compartment_70101", "id": "reaction_10726116", "reactome": "R-DDI-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726114" ], "products": [ "species_10669474" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10669494": { "compartment": "compartment_7660", "id": "reaction_10669494", "reactome": "R-DDI-68615", "name": "Formation of ORC(1-6) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669482", "species_10669490" ], "products": [ "species_10669492" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "DDB_G0284771", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10726142": { "compartment": "compartment_7660", "id": "reaction_10726142", "reactome": "R-DDI-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669474", "species_10726138" ], "products": [ "species_10726140" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54RM2", "DDB_G0283073", "Q76NW2", "DDB_G0276863" ] }, "reaction_10669469": { "compartment": "compartment_7660", "id": "reaction_10669469", "reactome": "R-DDI-68610", "name": "Formation of ORC(2-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669458", "species_10669465" ], "products": [ "species_10669467" ], "modifiers": [ [ "species_29358", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562" ] }, "reaction_10669484": { "compartment": "compartment_7660", "id": "reaction_10669484", "reactome": "R-DDI-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669467", "species_10669478" ], "products": [ "species_10669482" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10696023": { "compartment": "compartment_876", "id": "reaction_10696023", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10709790": { "compartment": "compartment_984", "id": "reaction_10709790", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_2160848", "species_5693343" ], "modifiers": [ [ "species_10709787", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10702727": { "compartment": "compartment_70101", "id": "reaction_10702727", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10683107" ], "products": [ "species_10702725" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54WU6", "DDB_G0279427", "Q54MV2", "DDB_G0285643" ] }, "reaction_10714788": { "compartment": "compartment_70101", "id": "reaction_10714788", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714777", "species_10714784" ], "products": [ "species_10714786" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10711995": { "compartment": "compartment_7660", "id": "reaction_10711995", "reactome": "R-DDI-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676302", "species_10711991" ], "products": [ "species_10711993" ], "modifiers": [], "additional_components": [ "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10714779": { "compartment": "compartment_876", "id": "reaction_10714779", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714775", "species_10714770" ], "products": [ "species_10714777" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10683116": { "compartment": "compartment_70101", "id": "reaction_10683116", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113", "species_29372" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10711979": { "compartment": "compartment_70101", "id": "reaction_10711979", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711969", "species_113592" ], "products": [ "species_29370", "species_10711977" ], "modifiers": [ [ "species_10680163", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10714366": { "compartment": "compartment_70101", "id": "reaction_10714366", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6799725" ], "products": [ "species_29366", "species_6799726" ], "modifiers": [ [ "species_10714301", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10714807": { "compartment": "compartment_17906", "id": "reaction_10714807", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10714802", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10712027": { "compartment": "compartment_7660", "id": "reaction_10712027", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712011" ], "products": [ "species_113582", "species_10712024" ], "modifiers": [ [ "species_10712011", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714862": { "compartment": "compartment_70101", "id": "reaction_10714862", "reactome": "R-DDI-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674703" ], "products": [ "species_10674705" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "P54632", "DDB_G0269138" ] }, "reaction_10671942": { "compartment": "compartment_70101", "id": "reaction_10671942", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10671939", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10670932": { "compartment": "compartment_70101", "id": "reaction_10670932", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10670929", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10712135": { "compartment": "compartment_70101", "id": "reaction_10712135", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712067", "species_10712131" ], "products": [ "species_10712133" ], "modifiers": [], "additional_components": [ "DDB_G0285069", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NU5", "DDB_G0285069", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029" ] }, "reaction_10714804": { "compartment": "compartment_17927", "id": "reaction_10714804", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714798", "species_10714793" ], "products": [ "species_10714802" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10714845": { "compartment": "compartment_7660", "id": "reaction_10714845", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10714828" ], "modifiers": [ [ "species_10714842", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q55G55", "DDB_G0267810", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10711989": { "compartment": "compartment_70101", "id": "reaction_10711989", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711977", "species_113592" ], "products": [ "species_29370", "species_10711987" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10712001": { "compartment": "compartment_7660", "id": "reaction_10712001", "reactome": "R-DDI-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711997", "species_10676302" ], "products": [ "species_10711999" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10702731": { "compartment": "compartment_70101", "id": "reaction_10702731", "reactome": "R-DDI-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680124", "species_10674719" ], "products": [ "species_10702729" ], "modifiers": [], "additional_components": [ "DDB_G0280527", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54VB2", "DDB_G0280527" ] }, "reaction_10712029": { "compartment": "compartment_7660", "id": "reaction_10712029", "reactome": "R-DDI-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711993", "species_10712009" ], "products": [ "species_10712011" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q556Z2", "DDB_G0273207", "Q54I13", "DDB_G0289079", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714303": { "compartment": "compartment_70101", "id": "reaction_10714303", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714299" ], "products": [ "species_10714301" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10699328": { "compartment": "compartment_70101", "id": "reaction_10699328", "reactome": "R-DDI-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10673826" ], "products": [ "species_10673820", "species_29356" ], "modifiers": [ [ "species_10699325", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q54N76", "DDB_G0285741", "Q555L5", "DDB_G0274859" ] }, "reaction_10714091": { "compartment": "compartment_7660", "id": "reaction_10714091", "reactome": "R-DDI-6799097", "name": "ATM phosphorylates ZNF420", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10688366" ], "products": [ "species_113582", "species_10714089" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0281085", "DDB_G0281085", "DDB_G0275845" ] }, "reaction_10702706": { "compartment": "compartment_70101", "id": "reaction_10702706", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10699317" ], "products": [ "species_29356", "species_10702703" ], "modifiers": [ [ "species_10699317", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10680127": { "compartment": "compartment_70101", "id": "reaction_10680127", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10680124" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10702723": { "compartment": "compartment_70101", "id": "reaction_10702723", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10702703" ], "products": [ "species_10702721" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10723422": { "compartment": "compartment_5460", "id": "reaction_10723422", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10723420": { "compartment": "compartment_5460", "id": "reaction_10723420", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692485": { "compartment": "compartment_70101", "id": "reaction_10692485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10724254": { "compartment": "compartment_5460", "id": "reaction_10724254", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724250" ], "products": [ "species_10723093", "species_1655881", "species_10699273" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10716446": { "compartment": "compartment_70101", "id": "reaction_10716446", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10716443", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10724248": { "compartment": "compartment_5460", "id": "reaction_10724248", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723093", "species_9012592" ], "products": [ "species_113557", "species_10724246" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10724252": { "compartment": "compartment_5460", "id": "reaction_10724252", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699270", "species_10724246" ], "products": [ "species_10724250" ], "modifiers": [], "additional_components": [ "DDB_G0284939", "DDB_G0291816", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10692483": { "compartment": "compartment_70101", "id": "reaction_10692483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692466": { "compartment": "compartment_70616", "id": "reaction_10692466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10723096": { "compartment": "compartment_5460", "id": "reaction_10723096", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692464": { "compartment": "compartment_5460", "id": "reaction_10692464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10692461", "catalyst" ] ], "additional_components": [ "species_947539", "Q54XJ8", "DDB_G0278893" ] }, "reaction_10692498": { "compartment": "compartment_70101", "id": "reaction_10692498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10692495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10723424": { "compartment": "compartment_5460", "id": "reaction_10723424", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692477": { "compartment": "compartment_70101", "id": "reaction_10692477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692488": { "compartment": "compartment_70101", "id": "reaction_10692488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10723006": { "compartment": "compartment_5460", "id": "reaction_10723006", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10723003", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_158543", "Q54YN2", "DDB_G0278155" ] }, "reaction_10677142": { "compartment": "compartment_12045", "id": "reaction_10677142", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_162681", "species_29420" ], "modifiers": [ [ "species_10677139", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q54LP3", "DDB_G0286519", "Q76NT6", "DDB_G0277435" ] }, "reaction_10681323": { "compartment": "compartment_70101", "id": "reaction_10681323", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681315" ], "products": [ "species_10681143", "species_29420" ], "modifiers": [ [ "species_10681320", "catalyst" ] ], "additional_components": [ "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "Q559R0", "DDB_G0272296", "DDB_G0286167" ] }, "reaction_10710261": { "compartment": "compartment_12045", "id": "reaction_10710261", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681221", "species_10681331" ], "products": [ "species_10681223" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710091": { "compartment": "compartment_12045", "id": "reaction_10710091", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681096", "species_10681325" ], "products": [ "species_10710089" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0269942", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255" ] }, "reaction_10715624": { "compartment": "compartment_432051", "id": "reaction_10715624", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715620", "species_10715492" ], "products": [ "species_10715622" ], "modifiers": [], "additional_components": [ "Q54I79", "DDB_G0288937", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "Q54VS0", "DDB_G0280175", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "P13022", "DDB_G0272104", "species_29438", "Q54XU5", "DDB_G0278579", "Q54N50", "DDB_G0285503", "P54703", "DDB_G0280849", "Q54TA6", "DDB_G0281889", "Q54VD6", "DDB_G0280435", "species_29420", "Q86A88", "DDB_G0274815", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "Q54ZI7", "DDB_G0277561", "P34036", "DDB_G0276355", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YD8", "DDB_G0278285", "Q54I79", "DDB_G0288937", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54VS0", "DDB_G0280175", "Q54NU2", "DDB_G0284985", "P54703", "DDB_G0280849", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "P34141", "DDB_G0291233", "P34036", "DDB_G0276355", "Q55FU2", "DDB_G0267950", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54N50", "DDB_G0285503", "Q54TA6", "DDB_G0281889", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54Q34", "DDB_G0349530", "Q54V78", "DDB_G0349530", "P13022", "DDB_G0272104", "Q54XU5", "DDB_G0278579", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q54VD6", "DDB_G0280435", "species_29420", "Q1ZXJ2", "DDB_G0294557", "Q54ZI7", "DDB_G0277561", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q86A88", "DDB_G0274815", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735" ] }, "reaction_10715495": { "compartment": "compartment_6791047", "id": "reaction_10715495", "reactome": "R-DDI-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715384" ], "products": [ "species_10715128", "species_10715276", "species_10715492", "species_10715194" ], "modifiers": [ [ "species_10715384", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716722": { "compartment": "compartment_6791047", "id": "reaction_10716722", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716717" ], "products": [ "species_10710015", "species_10716715" ], "modifiers": [ [ "species_10716717", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710154": { "compartment": "compartment_6791047", "id": "reaction_10710154", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710119", "species_10710150", "species_10710110" ], "products": [ "species_10710152" ], "modifiers": [], "additional_components": [ "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710161": { "compartment": "compartment_13959", "id": "reaction_10710161", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710064", "species_10710015", "species_10681311" ], "products": [ "species_10710066" ], "modifiers": [], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q55CT5", "DDB_G0270992", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10710218": { "compartment": "compartment_6791047", "id": "reaction_10710218", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10710176" ], "products": [ "species_29370", "species_10681091", "species_10710180", "species_10710182", "species_10710064", "species_10710103", "species_10710210" ], "modifiers": [ [ "species_10710215", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q553R1", "DDB_G0275331", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q54BK5", "DDB_G0293712", "Q553R1", "DDB_G0275331", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "DDB_G0273059" ] }, "reaction_10715198": { "compartment": "compartment_6791047", "id": "reaction_10715198", "reactome": "R-DDI-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715134", "species_10715194" ], "products": [ "species_10715196" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715136": { "compartment": "compartment_6791047", "id": "reaction_10715136", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715128", "species_10715132", "species_10710210" ], "products": [ "species_10715134" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716719": { "compartment": "compartment_6791047", "id": "reaction_10716719", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716715", "species_10710210" ], "products": [ "species_10716717" ], "modifiers": [], "additional_components": [ "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710157": { "compartment": "compartment_6791047", "id": "reaction_10710157", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710152", "species_113592" ], "products": [ "species_10710126", "species_10710131", "species_10710140", "species_10710124", "species_10710119", "species_10710148", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10710152", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0288719", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710264": { "compartment": "compartment_70101", "id": "reaction_10710264", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681223" ], "products": [ "species_10681221", "species_10681331", "species_29372", "species_10681315" ], "modifiers": [ [ "species_10681223", "catalyst" ] ], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29420", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10715205": { "compartment": "compartment_6791047", "id": "reaction_10715205", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10715196" ], "products": [ "species_10715202", "species_29370" ], "modifiers": [ [ "species_10715196", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715260": { "compartment": "compartment_6791047", "id": "reaction_10715260", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715202", "species_10715256" ], "products": [ "species_10715258" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10715820": { "compartment": "compartment_20699", "id": "reaction_10715820", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715816", "species_10710119", "species_10710110" ], "products": [ "species_10715818" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710087": { "compartment": "compartment_12045", "id": "reaction_10710087", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681157", "species_10681155" ], "products": [ "species_10681163" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0277797", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q55FD0", "DDB_G0268452" ] }, "reaction_10681337": { "compartment": "compartment_12045", "id": "reaction_10681337", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681229", "species_10681091", "species_10681104" ], "products": [ "species_10681231" ], "modifiers": [], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q55BR0", "DDB_G0269198", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q54T59", "DDB_G0281985", "Q55CT5", "DDB_G0270992", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "species_29438", "Q55BR0", "DDB_G0269198", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296" ] }, "reaction_10710159": { "compartment": "compartment_12045", "id": "reaction_10710159", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681217", "species_10681211" ], "products": [ "species_10681219" ], "modifiers": [], "additional_components": [ "DDB_G0280187", "Q8T2J5", "DDB_G0271968", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139" ] }, "reaction_10710073": { "compartment": "compartment_13959", "id": "reaction_10710073", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10710066" ], "products": [ "species_10710070", "species_29420" ], "modifiers": [ [ "species_10710066", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10715814": { "compartment": "compartment_20699", "id": "reaction_10715814", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715791", "species_10715810" ], "products": [ "species_10715812" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q55FD0", "DDB_G0268452", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "Q54QH2", "DDB_G0283831", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10715823": { "compartment": "compartment_20699", "id": "reaction_10715823", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715818", "species_113592" ], "products": [ "species_10715804", "species_10715796", "species_29372", "species_10715800", "species_10715779", "species_10715679", "species_10715798" ], "modifiers": [ [ "species_10715818", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0283831", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10725871": { "compartment": "compartment_70101", "id": "reaction_10725871", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10677557" ], "products": [ "species_10725869" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678991" ] }, "reaction_10689890": { "compartment": "compartment_876", "id": "reaction_10689890", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10689887", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724463": { "compartment": "compartment_876", "id": "reaction_10724463", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724456", "species_179838", "species_113592" ], "products": [ "species_29370", "species_10724461" ], "modifiers": [], "additional_components": [ "DDB_G0281265", "Q54U56", "DDB_G0281265", "species_179838" ] }, "reaction_10676519": { "compartment": "compartment_17906", "id": "reaction_10676519", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676517" ], "products": [ "species_10676515" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10675766": { "compartment": "compartment_7660", "id": "reaction_10675766", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672167", "species_10674774" ], "products": [ "species_10674776" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675764": { "compartment": "compartment_7660", "id": "reaction_10675764", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674115", "species_10674110", "species_10674772" ], "products": [ "species_10674774" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675762": { "compartment": "compartment_7660", "id": "reaction_10675762", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10674181" ], "products": [ "species_10674772" ], "modifiers": [], "additional_components": [ "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675768": { "compartment": "compartment_7660", "id": "reaction_10675768", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10674778" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674780": { "compartment": "compartment_7660", "id": "reaction_10674780", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674193", "species_10674776" ], "products": [ "species_10674778" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675912": { "compartment": "compartment_7660", "id": "reaction_10675912", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675909" ], "products": [ "species_10675902", "species_110216" ], "modifiers": [ [ "species_10675909", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675921": { "compartment": "compartment_7660", "id": "reaction_10675921", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675916" ], "products": [ "species_110223", "species_10675918" ], "modifiers": [ [ "species_10675916", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675942": { "compartment": "compartment_7660", "id": "reaction_10675942", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675939" ], "products": [ "species_10675918", "species_5637659" ], "modifiers": [ [ "species_10675939", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675905": { "compartment": "compartment_7660", "id": "reaction_10675905", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675898" ], "products": [ "species_10675902", "species_29554" ], "modifiers": [ [ "species_10675898", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675961": { "compartment": "compartment_7660", "id": "reaction_10675961", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675958" ], "products": [ "species_10675953", "species_5636006" ], "modifiers": [ [ "species_10675958", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675935": { "compartment": "compartment_7660", "id": "reaction_10675935", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675932" ], "products": [ "species_30140", "species_10675918" ], "modifiers": [ [ "species_10675932", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675928": { "compartment": "compartment_7660", "id": "reaction_10675928", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675925" ], "products": [ "species_10675918", "species_110225" ], "modifiers": [ [ "species_10675925", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10699054": { "compartment": "compartment_984", "id": "reaction_10699054", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10699051", "catalyst" ] ], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699338": { "compartment": "compartment_70101", "id": "reaction_10699338", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10699335", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54SE2", "DDB_G0282517", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10699064": { "compartment": "compartment_70101", "id": "reaction_10699064", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10699061", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10675004": { "compartment": "compartment_17951", "id": "reaction_10675004", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10675001", "catalyst" ] ], "additional_components": [ "O77229", "DDB_G0274595", "species_71185", "species_5623644" ] }, "reaction_10699781": { "compartment": "compartment_70101", "id": "reaction_10699781", "reactome": "R-DDI-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222481", "species_10673826" ], "products": [ "species_10673820", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10699323", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "DDB_G0285741" ] }, "reaction_10699292": { "compartment": "compartment_5460", "id": "reaction_10699292", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10699270" ], "products": [ "species_113521", "species_10699273" ], "modifiers": [ [ "species_10699289", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54N76", "DDB_G0285741", "Q54W09", "DDB_G0279973" ] }, "reaction_10699784": { "compartment": "compartment_5460", "id": "reaction_10699784", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3697881", "species_10699270" ], "products": [ "species_113521", "species_3697842", "species_10699273" ], "modifiers": [ [ "species_10699287", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10715116": { "compartment": "compartment_12045", "id": "reaction_10715116", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_70106", "species_29366", "species_1222424" ], "modifiers": [ [ "species_10715113", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10699307": { "compartment": "compartment_70616", "id": "reaction_10699307", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_3341308" ], "products": [ "species_10677282", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10699937": { "compartment": "compartment_17927", "id": "reaction_10699937", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10699934", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10698995": { "compartment": "compartment_5460", "id": "reaction_10698995", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10698992", "catalyst" ] ], "additional_components": [ "species_29418", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10700993": { "compartment": "compartment_17963", "id": "reaction_10700993", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700991" ], "products": [ "species_10699051" ], "modifiers": [], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420", "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699301": { "compartment": "compartment_5460", "id": "reaction_10699301", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10699298", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10697280": { "compartment": "compartment_70101", "id": "reaction_10697280", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10697277", "catalyst" ] ], "additional_components": [ "Q54S89", "DDB_G0282603", "species_29926" ] }, "reaction_10670550": { "compartment": "compartment_7660", "id": "reaction_10670550", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670546", "species_10670361" ], "products": [ "species_10670548" ], "modifiers": [], "additional_components": [ "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702" ] }, "reaction_10670588": { "compartment": "compartment_7660", "id": "reaction_10670588", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670563", "species_10670584" ], "products": [ "species_10670586" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670565": { "compartment": "compartment_7660", "id": "reaction_10670565", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670559" ], "products": [ "species_10670546", "species_10670563" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607" ] }, "reaction_10670561": { "compartment": "compartment_7660", "id": "reaction_10670561", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_29358", "species_10670548" ], "products": [ "species_113582", "species_10670559" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702" ] }, "reaction_10716868": { "compartment": "compartment_20699", "id": "reaction_10716868", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716859" ], "products": [ "species_10716865" ], "modifiers": [ [ "species_10716859", "catalyst" ] ], "additional_components": [ "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771", "species_29420", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10717007": { "compartment": "compartment_20699", "id": "reaction_10717007", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717003", "species_10715666" ], "products": [ "species_10717005" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716805": { "compartment": "compartment_20699", "id": "reaction_10716805", "reactome": "R-DDI-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716801" ], "products": [ "species_10716803" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "O00909", "DDB_G0289173", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "CHEBI:15996" ] }, "reaction_10716884": { "compartment": "compartment_20699", "id": "reaction_10716884", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716880", "species_10716874" ], "products": [ "species_10716882" ], "modifiers": [], "additional_components": [ "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716861": { "compartment": "compartment_20699", "id": "reaction_10716861", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716831" ], "products": [ "species_10716859" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10716313": { "compartment": "compartment_20699", "id": "reaction_10716313", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716309", "species_10715666" ], "products": [ "species_10716311" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q551H5", "DDB_G0276575", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q55FD0", "DDB_G0268452", "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q551H5", "DDB_G0276575", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716784": { "compartment": "compartment_20699", "id": "reaction_10716784", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716780", "species_10710119", "species_10710110" ], "products": [ "species_10716782" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10716787": { "compartment": "compartment_20699", "id": "reaction_10716787", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716782" ], "products": [ "species_29370", "species_10715796", "species_10710119", "species_10715800", "species_10715679", "species_10710110", "species_10715798" ], "modifiers": [ [ "species_10716782", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0277565", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10709489": { "compartment": "compartment_70101", "id": "reaction_10709489", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709484", "species_29356" ], "products": [ "species_1131871", "species_10709486" ], "modifiers": [ [ "species_10709484", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10703500": { "compartment": "compartment_70101", "id": "reaction_10703500", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703441", "species_10670356" ], "products": [ "species_10703443" ], "modifiers": [], "additional_components": [ "DDB_G0272624", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703447": { "compartment": "compartment_70101", "id": "reaction_10703447", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703443", "species_10703436" ], "products": [ "species_10703445" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "DDB_G0285527", "Q54N38", "DDB_G0285527", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10717861": { "compartment": "compartment_70101", "id": "reaction_10717861", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717713" ], "products": [ "species_76577", "species_10717709" ], "modifiers": [ [ "species_10717713", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10702140": { "compartment": "compartment_70101", "id": "reaction_10702140", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702129" ], "products": [ "species_10702132", "species_71285" ], "modifiers": [ [ "species_10702137", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10700403": { "compartment": "compartment_7660", "id": "reaction_10700403", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10696675" ], "products": [ "species_10698305", "species_10700401" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10673665": { "compartment": "compartment_70101", "id": "reaction_10673665", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673661", "species_10673298" ], "products": [ "species_10673300" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10687107": { "compartment": "compartment_17957", "id": "reaction_10687107", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686806", "species_10687103" ], "products": [ "species_10687105" ], "modifiers": [], "additional_components": [ "Q54BW3", "DDB_G0293378", "Q54EN4", "DDB_G0291434", "Q23858", "DDB_G0283539", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "Q54BW3", "DDB_G0293378", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q54EN4", "DDB_G0291434" ] }, "reaction_10700206": { "compartment": "compartment_7660", "id": "reaction_10700206", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684083", "species_10698318" ], "products": [ "species_10698305", "species_10700198" ], "modifiers": [ [ "species_10700203", "catalyst" ] ], "additional_components": [ "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54UJ3", "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "DDB_G0281183" ] }, "reaction_10700515": { "compartment": "compartment_7660", "id": "reaction_10700515", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700491" ], "products": [ "species_10700504", "species_10698305" ], "modifiers": [ [ "species_10700512", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0278203", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10705691": { "compartment": "compartment_3828046", "id": "reaction_10705691", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705524", "species_5685882" ], "products": [ "species_10705620", "species_10705588", "species_10705556" ], "modifiers": [ [ "species_10705688", "catalyst" ] ], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10683855": { "compartment": "compartment_70101", "id": "reaction_10683855", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683798", "species_10683851" ], "products": [ "species_10683853" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q6B516", "DDB_G0284545", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741" ] }, "reaction_10673340": { "compartment": "compartment_70101", "id": "reaction_10673340", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673329" ], "products": [ "species_29370", "species_10673329", "species_29372" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10684883": { "compartment": "compartment_17938", "id": "reaction_10684883", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10684880", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10685907": { "compartment": "compartment_70101", "id": "reaction_10685907", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10685904", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10709063": { "compartment": "compartment_7660", "id": "reaction_10709063", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10707630" ], "products": [ "species_10709060", "species_10707644" ], "modifiers": [ [ "species_10707630", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10685919": { "compartment": "compartment_5460", "id": "reaction_10685919", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10685916", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10676992": { "compartment": "compartment_70101", "id": "reaction_10676992", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676983", "species_10676987" ], "products": [ "species_10676969", "species_10676989" ], "modifiers": [ [ "species_10676983", "catalyst" ] ], "additional_components": [ "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10724695": { "compartment": "compartment_12045", "id": "reaction_10724695", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724693" ], "products": [ "species_10705524" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10682226": { "compartment": "compartment_876", "id": "reaction_10682226", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682212", "species_10682207", "species_10682222", "species_10682192", "species_10682187", "species_10682217", "species_10682197", "species_10682202" ], "products": [ "species_10682224" ], "modifiers": [], "additional_components": [ "DDB_G0285067", "DDB_G0279991", "DDB_G0272991", "DDB_G0280081", "DDB_G0284833", "DDB_G0293520", "DDB_G0287881", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54VX5", "DDB_G0280081", "Q558Z9", "DDB_G0272991", "Q54VZ8", "DDB_G0279991", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54P76", "DDB_G0284833", "Q54B27", "DDB_G0293936" ] }, "reaction_10710630": { "compartment": "compartment_7660", "id": "reaction_10710630", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710625" ], "products": [ "species_10709060", "species_10710627" ], "modifiers": [ [ "species_10710625", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10698407": { "compartment": "compartment_7660", "id": "reaction_10698407", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698318" ], "products": [ "species_10698305", "species_10698405" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54C05", "DDB_G0293300", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710874": { "compartment": "compartment_7660", "id": "reaction_10710874", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710869" ], "products": [ "species_10708452", "species_10710871" ], "modifiers": [ [ "species_10710869", "catalyst" ] ], "additional_components": [ "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827" ] }, "reaction_10686727": { "compartment": "compartment_70101", "id": "reaction_10686727", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10686724", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10711136": { "compartment": "compartment_70101", "id": "reaction_10711136", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10711133", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10722373": { "compartment": "compartment_17947", "id": "reaction_10722373", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722365", "species_10722369" ], "products": [ "species_10722371" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10711128": { "compartment": "compartment_70101", "id": "reaction_10711128", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10687947": { "compartment": "compartment_70101", "id": "reaction_10687947", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687940" ], "products": [ "species_10670153", "species_10687942" ], "modifiers": [ [ "species_10687944", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10673351": { "compartment": "compartment_70101", "id": "reaction_10673351", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673316", "species_10673311", "species_10673321" ], "products": [ "species_10673323" ], "modifiers": [], "additional_components": [ "DDB_G0268574", "P90529", "DDB_G0269146", "DDB_G0275395", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574" ] }, "reaction_10702162": { "compartment": "compartment_70101", "id": "reaction_10702162", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702142" ], "products": [ "species_353106", "species_10702129" ], "modifiers": [ [ "species_10702159", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "B0G132", "DDB_G0295687", "Q54PW5", "DDB_G0284257", "Q7KWL8", "DDB_G0277061" ] }, "reaction_10673659": { "compartment": "compartment_70101", "id": "reaction_10673659", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673640" ], "products": [ "species_10673277", "species_10673638", "species_10673208" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0278205", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10709775": { "compartment": "compartment_984", "id": "reaction_10709775", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_109276" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10709772", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10722383": { "compartment": "compartment_17947", "id": "reaction_10722383", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722371" ], "products": [ "species_10690046", "species_10722380" ], "modifiers": [ [ "species_10722371", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10673655": { "compartment": "compartment_70101", "id": "reaction_10673655", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673649" ], "products": [ "species_10673651", "species_29372", "species_10673653" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", 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"Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "species_29420", "Q54XP6", "DDB_G0278815", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10677197": { "compartment": "compartment_12045", "id": "reaction_10677197", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10677194", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10681359": { "compartment": "compartment_70101", "id": "reaction_10681359", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_204628", "species_10681343" ], "products": [ "species_29360", "species_204635", "species_10681347" ], "modifiers": [ [ "species_10681356", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10688493": { "compartment": "compartment_17963", "id": "reaction_10688493", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10688490", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10717967": { "compartment": "compartment_70101", "id": "reaction_10717967", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717965" ], "products": [ "species_10669997", "species_10669975", "species_10670019" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10702126": { "compartment": "compartment_70101", "id": "reaction_10702126", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_31633", "species_10702118" ], "products": [ "species_10676998", "species_111294", "species_76577" ], "modifiers": [ [ "species_10702123", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10698428": { "compartment": "compartment_7660", "id": "reaction_10698428", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698412", "species_10698318" ], "products": [ "species_10698305", "species_10698425" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54LN0", "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10716428": { "compartment": "compartment_70101", "id": "reaction_10716428", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682961", "species_10683851" ], "products": [ "species_10716426" ], "modifiers": [], "additional_components": [ "DDB_G0277143", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10721435": { "compartment": "compartment_70101", "id": "reaction_10721435", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721415", "species_10721431", "species_10721429" ], "products": [ "species_10721433" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10677189": { "compartment": "compartment_12045", "id": "reaction_10677189", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10677186", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10721463": { "compartment": "compartment_70101", "id": "reaction_10721463", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721452", "species_10721450" ], "products": [ "species_10721443", "species_10721460", "species_10680834" ], "modifiers": [ [ "species_10721452", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0277267", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10700718": { "compartment": "compartment_7660", "id": "reaction_10700718", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670555", "species_10698318" ], "products": [ "species_10698305", "species_10700716" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10721734": { "compartment": "compartment_7660", "id": "reaction_10721734", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721712", "species_10721731" ], "products": [ "species_10721719", "species_10705259", "species_10721729", "species_10721706" ], "modifiers": [ [ "species_10721731", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082", "Q54K47", "DDB_G0287607", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "DDB_G0272082", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10700659": { "compartment": "compartment_7660", "id": "reaction_10700659", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700639" ], "products": [ "species_10698305", "species_10700657" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0272690", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685756": { "compartment": "compartment_70101", "id": "reaction_10685756", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10685753", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10685711": { "compartment": "compartment_17957", "id": "reaction_10685711", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10685708", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10719651": { "compartment": "compartment_70101", "id": "reaction_10719651", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719273", "species_10719647" ], "products": [ "species_10719649" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10711110": { "compartment": "compartment_70101", "id": "reaction_10711110", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10711107", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10700169": { "compartment": "compartment_7660", "id": "reaction_10700169", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698318" ], "products": [ "species_10698305", "species_10700167" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10707595": { "compartment": "compartment_70101", "id": "reaction_10707595", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707592", "species_10689017" ], "products": [ "species_10706130" ], "modifiers": [ [ "species_10689017", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10711231": { "compartment": "compartment_12045", "id": "reaction_10711231", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ] ], "additional_components": [ "species_29426", "Q558K8", "DDB_G0272799" ] }, "reaction_10717943": { "compartment": "compartment_70101", "id": "reaction_10717943", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717940" ], "products": [ "species_10670107", "species_10669997", "species_10670151", "species_10670085", "species_10670063", "species_10669975", "species_10670041", "species_10670019", "species_10670129" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10672012": { "compartment": "compartment_70101", "id": "reaction_10672012", "reactome": "R-DDI-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10672009", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10717761": { "compartment": "compartment_70101", "id": "reaction_10717761", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717711", "species_10717707" ], "products": [ "species_10717759", "species_10717713" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q75JE1", "DDB_G0288345", "O76542", "DDB_G0284009", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10685772": { "compartment": "compartment_12045", "id": "reaction_10685772", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10685769", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10685897": { "compartment": "compartment_70101", "id": "reaction_10685897", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10685894", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10687188": { "compartment": "compartment_17963", "id": "reaction_10687188", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_205687", "species_10687186" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700814": { "compartment": "compartment_7660", "id": "reaction_10700814", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700799", "species_10698318" ], "products": [ "species_10698305", "species_10700812" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54RC3", "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717887": { "compartment": "compartment_70101", "id": "reaction_10717887", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689659", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10717884", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628", "species_6799543", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10716434": { "compartment": "compartment_70101", "id": "reaction_10716434", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716432" ], "products": [ "species_10716426", "species_29372" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10677122": { "compartment": "compartment_17957", "id": "reaction_10677122", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10677119", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10711139": { "compartment": "compartment_70101", "id": "reaction_10711139", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10673349": { "compartment": "compartment_70101", "id": "reaction_10673349", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347" ], "products": [ "species_10673345", "species_10673316" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10685719": { "compartment": "compartment_12045", "id": "reaction_10685719", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449744", "species_29356" ], "products": [ "species_449299", "species_29372" ], "modifiers": [ [ "species_10685716", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10698470": { "compartment": "compartment_7660", "id": "reaction_10698470", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698438" ], "products": [ "species_10698305", "species_10698453" ], "modifiers": [ [ "species_10698467", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0285989", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54MF7", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10711352": { "compartment": "compartment_3828046", "id": "reaction_10711352", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705556" ], "products": [ "species_10705693" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10677228": { "compartment": "compartment_12045", "id": "reaction_10677228", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855665", "species_449229" ], "products": [ "species_162872", "species_8855659" ], "modifiers": [ [ "species_10677225", "catalyst" ] ], "additional_components": [ "Q54IA4", "DDB_G0288899", "Q54QP2", "DDB_G0283717" ] }, "reaction_10717705": { "compartment": "compartment_7660", "id": "reaction_10717705", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717501", "species_29358", "species_10669917" ], "products": [ "species_10717703", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721722": { "compartment": "compartment_7660", "id": "reaction_10721722", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721714", "species_10721712" ], "products": [ "species_10721719", "species_10721697", "species_10705259", "species_10721706" ], "modifiers": [ [ "species_10721714", "catalyst" ] ], "additional_components": [ "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10721724": { "compartment": "compartment_7660", "id": "reaction_10721724", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721697", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721714" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10719266": { "compartment": "compartment_70101", "id": "reaction_10719266", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719256", "species_10719262" ], "products": [ "species_10719264" ], "modifiers": [ [ "species_10719258", "inhibitor" ] ], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10718520": { "compartment": "compartment_7660", "id": "reaction_10718520", "reactome": "R-DDI-8862184", "name": "USP48 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718471" ], "products": [ "species_10718517", "species_10708452" ], "modifiers": [ [ "species_10718471", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961" ] }, "reaction_10700592": { "compartment": "compartment_7660", "id": "reaction_10700592", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10674568" ], "products": [ "species_10698305", "species_10700590" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0276863", "DDB_G0287693", "DDB_G0276863", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10707609": { "compartment": "compartment_70101", "id": "reaction_10707609", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707605", "species_10703443" ], "products": [ "species_10707607" ], "modifiers": [], "additional_components": [ "DDB_G0271264", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q55BC4", "DDB_G0271264", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10719260": { "compartment": "compartment_70101", "id": "reaction_10719260", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719254", "species_10719256" ], "products": [ "species_10719258" ], "modifiers": [], "additional_components": [ "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10700140": { "compartment": "compartment_7660", "id": "reaction_10700140", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698387", "species_10698318" ], "products": [ "species_10698305", "species_10700138" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676985": { "compartment": "compartment_70101", "id": "reaction_10676985", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676976", "species_10676974", "species_10676981" ], "products": [ "species_10676983" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0284035", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10717858": { "compartment": "compartment_70101", "id": "reaction_10717858", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10717709" ], "products": [ "species_10717711", "species_111294" ], "modifiers": [ [ "species_10717709", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10720438": { "compartment": "compartment_70101", "id": "reaction_10720438", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720435" ], "products": [ "species_10680330" ], "modifiers": [ [ "species_10715078", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0267906" ] }, "reaction_10700761": { "compartment": "compartment_7660", "id": "reaction_10700761", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700746" ], "products": [ "species_10698305", "species_10700759" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0270418", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717853": { "compartment": "compartment_7660", "id": "reaction_10717853", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717765", "species_10717800" ], "products": [ "species_10717851", "species_10717703" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721441": { "compartment": "compartment_70101", "id": "reaction_10721441", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721433", "species_10721431" ], "products": [ "species_10689176", "species_10721438", "species_10721429" ], "modifiers": [ [ "species_10721433", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0281167", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10676955": { "compartment": "compartment_70101", "id": "reaction_10676955", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673638" ], "products": [ "species_10673430", "species_10676953" ], "modifiers": [], "additional_components": [ "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0275881", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10710713": { "compartment": "compartment_70101", "id": "reaction_10710713", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710704", "species_29356" ], "products": [ "species_10678140", "species_10710710" ], "modifiers": [ [ "species_10710704", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021" ] }, "reaction_10685790": { "compartment": "compartment_12045", "id": "reaction_10685790", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10685787", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10685738": { "compartment": "compartment_70101", "id": "reaction_10685738", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10685735", "catalyst" ] ], "additional_components": [ "Q86B09", "DDB_G0272781", "Q54X03", "DDB_G0279289" ] }, "reaction_10700634": { "compartment": "compartment_7660", "id": "reaction_10700634", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700619" ], "products": [ "species_10698305", "species_10700632" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0292296", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10689669": { "compartment": "compartment_20699", "id": "reaction_10689669", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10689666", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10685695": { "compartment": "compartment_12045", "id": "reaction_10685695", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10685692", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10705340": { "compartment": "compartment_2133233", "id": "reaction_10705340", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10705337", "catalyst" ] ], "additional_components": [ "species_1524042", "species_426925", "species_1524042", "species_426925", "DDB_G0291994" ] }, "reaction_10677244": { "compartment": "compartment_12045", "id": "reaction_10677244", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10677241", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10717918": { "compartment": "compartment_70101", "id": "reaction_10717918", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717916" ], "products": [ "species_10669973", "species_10673551" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "DDB_G0281703", "DDB_G0281703", "DDB_G0281703", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10718833": { "compartment": "compartment_70101", "id": "reaction_10718833", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_10683047", "species_113592" ], "products": [ "species_29370", "species_10718821", "species_29372" ], "modifiers": [ [ "species_10718830", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54TU1", "DDB_G0281541" ] }, "reaction_10677174": { "compartment": "compartment_70101", "id": "reaction_10677174", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_110096", "species_8855657" ], "modifiers": [ [ "species_10677171", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q86K35", "DDB_G0277289", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515", "Q54QB2", "DDB_G0283965", "Q86JM6", "DDB_G0272006" ] }, "reaction_10693457": { "compartment": "compartment_70101", "id": "reaction_10693457", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693453", "species_10693451" ], "products": [ "species_10693455" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q75K18", "DDB_G0275455", "Q554G7", "DDB_G0275211", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q1ZXE8", "DDB_G0285821", "Q55GL2", "DDB_G0267622", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q556L1", "DDB_G0272590", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q1ZXE8", "DDB_G0285821", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54EP7", "DDB_G0291412", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q554G7", "DDB_G0275211", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q75K18", "DDB_G0275455", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q55GL2", "DDB_G0267622", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700486": { "compartment": "compartment_7660", "id": "reaction_10700486", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10696675" ], "products": [ "species_10698305", "species_10700484" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10709672": { "compartment": "compartment_70101", "id": "reaction_10709672", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10670158", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0272566" ] }, "reaction_10717499": { "compartment": "compartment_70101", "id": "reaction_10717499", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717444", "species_10717446" ], "products": [ "species_10717448", "species_10717497" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q555G0", "DDB_G0274897", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721736": { "compartment": "compartment_7660", "id": "reaction_10721736", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721729", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721731" ], "modifiers": [], "additional_components": [ "DDB_G0272082", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10721572": { "compartment": "compartment_984", "id": "reaction_10721572", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10721532" ], "products": [ "species_2197633", "species_10721564" ], "modifiers": [ [ "species_10721569", "catalyst" ] ], "additional_components": [ "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "DDB_G0276919" ] }, "reaction_10685457": { "compartment": "compartment_1462052", "id": "reaction_10685457", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685454", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10685780": { "compartment": "compartment_17957", "id": "reaction_10685780", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10716436": { "compartment": "compartment_70101", "id": "reaction_10716436", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716426" ], "products": [ "species_10716432", "species_29370" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10698263": { "compartment": "compartment_7660", "id": "reaction_10698263", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698249" ], "products": [ "species_10687009" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685703": { "compartment": "compartment_12045", "id": "reaction_10685703", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449221", "species_110614" ], "products": [ "species_449299", "species_110094" ], "modifiers": [ [ "species_10685700", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10710774": { "compartment": "compartment_70101", "id": "reaction_10710774", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_10710770" ], "products": [ "species_10710772" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "P90532", "DDB_G0288065", "Q55BI3", "DDB_G0271346" ] }, "reaction_10717864": { "compartment": "compartment_70101", "id": "reaction_10717864", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10689276" ], "products": [ "species_111294", "species_10717713" ], "modifiers": [ [ "species_10689276", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272" ] }, "reaction_10709185": { "compartment": "compartment_7660", "id": "reaction_10709185", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10709180" ], "products": [ "species_10709182", "species_10669917" ], "modifiers": [ [ "species_10709180", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207" ] }, "reaction_10685465": { "compartment": "compartment_20699", "id": "reaction_10685465", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685462", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10700068": { "compartment": "compartment_7660", "id": "reaction_10700068", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700053" ], "products": [ "species_10698305", "species_10700066" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0293168", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685746": { "compartment": "compartment_17957", "id": "reaction_10685746", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10685743", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10709951": { "compartment": "compartment_17963", "id": "reaction_10709951", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10687208": { "compartment": "compartment_17963", "id": "reaction_10687208", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_10687206", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700701": { "compartment": "compartment_7660", "id": "reaction_10700701", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10690036" ], "products": [ "species_10698305", "species_10700699" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700091": { "compartment": "compartment_7660", "id": "reaction_10700091", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698318" ], "products": [ "species_10698305", "species_10700089" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700359": { "compartment": "compartment_12045", "id": "reaction_10700359", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10709911": { "compartment": "compartment_161320", "id": "reaction_10709911", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10709908", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10700546": { "compartment": "compartment_7660", "id": "reaction_10700546", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700537", "species_10698378" ], "products": [ "species_10698305", "species_10700543" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700462": { "compartment": "compartment_7660", "id": "reaction_10700462", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700203" ], "products": [ "species_10698305", "species_10700460" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0281183", "DDB_G0287693", "Q54UA7", "DDB_G0281183", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10719275": { "compartment": "compartment_70101", "id": "reaction_10719275", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719271", "species_10719264", "species_1131164" ], "products": [ "species_10719273" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10700644": { "compartment": "compartment_7660", "id": "reaction_10700644", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700639" ], "products": [ "species_10698305", "species_10700642" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0272690", "DDB_G0287693", "DDB_G0272690", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10673657": { "compartment": "compartment_70101", "id": "reaction_10673657", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673336", "species_10673638", "species_10673647" ], "products": [ "species_10673649" ], "modifiers": [], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54XP6", "DDB_G0278815", "species_29438", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "species_29438", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700794": { "compartment": "compartment_7660", "id": "reaction_10700794", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700746" ], "products": [ "species_10698305", "species_10700792" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0270418", "DDB_G0287693", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10700185": { "compartment": "compartment_7660", "id": "reaction_10700185", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698750" ], "products": [ "species_10698305", "species_10700183" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0279509", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10710812": { "compartment": "compartment_70101", "id": "reaction_10710812", "reactome": "R-DDI-6782106", "name": "USP10 deubiquitinates SNX3, CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710805", "species_29356" ], "products": [ "species_10707592", "species_10710809" ], "modifiers": [ [ "species_10710805", "catalyst" ] ], "additional_components": [ "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021" ] }, "reaction_10689661": { "compartment": "compartment_70101", "id": "reaction_10689661", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689657" ], "products": [ "species_10689659" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628" ] }, "reaction_10698392": { "compartment": "compartment_7660", "id": "reaction_10698392", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698378" ], "products": [ "species_10698305", "species_10698381" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10698599": { "compartment": "compartment_7660", "id": "reaction_10698599", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10697630" ], "products": [ "species_10698305", "species_10698563" ], "modifiers": [ [ "species_10698596", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0287693", "Q54QR0", "DDB_G0283681", "Q8N0B4", "DDB_G0286189", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q55FZ7", "DDB_G0267886", "Q552D9", "DDB_G0276101", "Q54FE3", "DDB_G0290919", "Q54X37", "DDB_G0279231", "Q54T56", "DDB_G0281991", "Q54I56", "DDB_G0288993", "Q54PA3", "DDB_G0284679", "Q54HN3", "DDB_G0289341" ] }, "reaction_10698300": { "compartment": "compartment_7660", "id": "reaction_10698300", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698296" ], "products": [ "species_10698298" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10677213": { "compartment": "compartment_12045", "id": "reaction_10677213", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10677210", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10710428": { "compartment": "compartment_70101", "id": "reaction_10710428", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710419", "species_29356" ], "products": [ "species_10707592", "species_10710425" ], "modifiers": [ [ "species_10710419", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617" ] }, "reaction_10710452": { "compartment": "compartment_7660", "id": "reaction_10710452", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710445", "species_113518" ], "products": [ "species_10709060", "species_10710449" ], "modifiers": [ [ "species_10710445", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10719196": { "compartment": "compartment_70101", "id": "reaction_10719196", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10719191" ], "products": [ "species_10707592", "species_10719193" ], "modifiers": [ [ "species_10710400", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "B0G199", "DDB_G0293770", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "DDB_G0293770" ] }, "reaction_10710405": { "compartment": "compartment_70101", "id": "reaction_10710405", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710396", "species_29356" ], "products": [ "species_10707592", "species_10710398" ], "modifiers": [ [ "species_10710396", "catalyst" ] ], "additional_components": [ "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407" ] }, "reaction_10673667": { "compartment": "compartment_70101", "id": "reaction_10673667", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "products": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753" ] }, "reaction_10700260": { "compartment": "compartment_7660", "id": "reaction_10700260", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700245" ], "products": [ "species_10698305", "species_10700258" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0283605", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673359": { "compartment": "compartment_70101", "id": "reaction_10673359", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673296", "species_72393" ], "products": [ "species_10673298" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10698243": { "compartment": "compartment_7660", "id": "reaction_10698243", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698225", "species_10687009", "species_29358" ], "products": [ "species_10698240", "species_164121", "species_113541" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10698321": { "compartment": "compartment_7660", "id": "reaction_10698321", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698240" ], "products": [ "species_10698225", "species_10698318" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10717914": { "compartment": "compartment_70101", "id": "reaction_10717914", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669975" ], "products": [ "species_10673140", "species_10669975" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10677002": { "compartment": "compartment_70101", "id": "reaction_10677002", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676998" ], "products": [ "species_10677000" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10676951": { "compartment": "compartment_70101", "id": "reaction_10676951", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676926", "species_10676947" ], "products": [ "species_10676949" ], "modifiers": [], "additional_components": [ "DDB_G0275881", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10706098": { "compartment": "compartment_70101", "id": "reaction_10706098", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140", "species_29356" ], "products": [ "species_10678140", "species_10678138" ], "modifiers": [ [ "species_10706095", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DI9", "DDB_G0269646" ] }, "reaction_10698483": { "compartment": "compartment_7660", "id": "reaction_10698483", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10698438" ], "products": [ "species_10698305", "species_10698480" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0285989", "DDB_G0287693", "DDB_G0285989", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10717855": { "compartment": "compartment_7660", "id": "reaction_10717855", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10717763", "species_10669917" ], "products": [ "species_10717765", "species_113541" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10710584": { "compartment": "compartment_70101", "id": "reaction_10710584", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710535", "species_29356" ], "products": [ "species_10710581", "species_10678140" ], "modifiers": [ [ "species_10710535", "catalyst" ] ], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202" ] }, "reaction_10700105": { "compartment": "compartment_7660", "id": "reaction_10700105", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698368" ], "products": [ "species_10698305", "species_10700102" ], "modifiers": [ [ "species_10686997", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10717866": { "compartment": "compartment_7660", "id": "reaction_10717866", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717703" ], "products": [ "species_10717763", "species_164121" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10686910": { "compartment": "compartment_20699", "id": "reaction_10686910", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10686907", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10700741": { "compartment": "compartment_7660", "id": "reaction_10700741", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10699886" ], "products": [ "species_10698305", "species_10700739" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700532": { "compartment": "compartment_7660", "id": "reaction_10700532", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988", "species_10698318" ], "products": [ "species_10698305", "species_10700530" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0269406", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677205": { "compartment": "compartment_12045", "id": "reaction_10677205", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10677202", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10709123": { "compartment": "compartment_70101", "id": "reaction_10709123", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709118", "species_29356" ], "products": [ "species_10670153", "species_10709120" ], "modifiers": [ [ "species_10709118", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239" ] }, "reaction_10699567": { "compartment": "compartment_7660", "id": "reaction_10699567", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10699553" ], "products": [ "species_10698305", "species_10699556" ], "modifiers": [ [ "species_10699564", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0293468", "DDB_G0287693", "DDB_G0293468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710662": { "compartment": "compartment_7660", "id": "reaction_10710662", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710657" ], "products": [ "species_10669917", "species_10710659" ], "modifiers": [ [ "species_10710657", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273" ] }, "reaction_10700223": { "compartment": "compartment_7660", "id": "reaction_10700223", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700208" ], "products": [ "species_10698305", "species_10700221" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0284411", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677236": { "compartment": "compartment_70101", "id": "reaction_10677236", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10677233", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10710615": { "compartment": "compartment_7660", "id": "reaction_10710615", "reactome": "R-DDI-5696947", "name": "USP47 deubiquitinates POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710610", "species_113518" ], "products": [ "species_10709060", "species_10710612" ], "modifiers": [ [ "species_10710610", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611" ] }, "reaction_10685782": { "compartment": "compartment_17957", "id": "reaction_10685782", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10673663": { "compartment": "compartment_70101", "id": "reaction_10673663", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673208", "species_10673272" ], "products": [ "species_10673661" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54X97", "DDB_G0279109", "Q54CC5", "DDB_G0293052", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "Q54EQ1", "DDB_G0291404", "Q54UD0", "DDB_G0281153", "Q54MT0", "DDB_G0285683", "Q86B20", "DDB_G0272078", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q554U9", "DDB_G0274627", "Q54KZ8", "DDB_G0287005", "Q54C49", "DDB_G0293254", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10700351": { "compartment": "compartment_12045", "id": "reaction_10700351", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10700348", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10685687": { "compartment": "compartment_17957", "id": "reaction_10685687", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10685684", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10687242": { "compartment": "compartment_17963", "id": "reaction_10687242", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10687149" ], "products": [ "species_205687", "species_10687240" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700789": { "compartment": "compartment_7660", "id": "reaction_10700789", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700770" ], "products": [ "species_10698305", "species_10700787" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "P90520", "DDB_G0279737", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10698272": { "compartment": "compartment_7660", "id": "reaction_10698272", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698268" ], "products": [ "species_10698270" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685678": { "compartment": "compartment_17957", "id": "reaction_10685678", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10685670", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10687198": { "compartment": "compartment_17963", "id": "reaction_10687198", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10687149" ], "products": [ "species_205687", "species_10687196" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10710692": { "compartment": "compartment_7660", "id": "reaction_10710692", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710685" ], "products": [ "species_10709060", "species_10710689" ], "modifiers": [ [ "species_10710685", "catalyst" ] ], "additional_components": [ "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453" ] }, "reaction_10700614": { "compartment": "compartment_7660", "id": "reaction_10700614", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10674568" ], "products": [ "species_10698305", "species_10700612" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0276863", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q76NW2", "DDB_G0276863", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673357": { "compartment": "compartment_70101", "id": "reaction_10673357", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673294" ], "products": [ "species_10673296" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10711118": { "compartment": "compartment_70101", "id": "reaction_10711118", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10711115", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10710386": { "compartment": "compartment_70101", "id": "reaction_10710386", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10710383", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0284037" ] }, "reaction_10720401": { "compartment": "compartment_70101", "id": "reaction_10720401", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719649", "species_1131164" ], "products": [ "species_111294", "species_10720396", "species_10720398" ], "modifiers": [ [ "species_10719649", "catalyst" ] ], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10681376": { "compartment": "compartment_70101", "id": "reaction_10681376", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10681343", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10681364" ], "modifiers": [ [ "species_10681373", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "species_71067", "Q556G4", "DDB_G0272634" ] }, "reaction_10685764": { "compartment": "compartment_12045", "id": "reaction_10685764", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10685761", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10721465": { "compartment": "compartment_70101", "id": "reaction_10721465", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721443", "species_10721445", "species_10721450" ], "products": [ "species_10721452" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10670813": { "compartment": "compartment_7660", "id": "reaction_10670813", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10670825": { "compartment": "compartment_7660", "id": "reaction_10670825", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10670792": { "compartment": "compartment_70101", "id": "reaction_10670792", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670790" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10696253": { "compartment": "compartment_161320", "id": "reaction_10696253", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10724755": { "compartment": "compartment_161320", "id": "reaction_10724755", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10710763": { "compartment": "compartment_7660", "id": "reaction_10710763", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710740", "species_10669917" ], "products": [ "species_10710760" ], "modifiers": [ [ "species_10710740", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710800": { "compartment": "compartment_7660", "id": "reaction_10710800", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710791", "species_113518" ], "products": [ "species_10710797", "species_10669917" ], "modifiers": [ [ "species_10710791", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10710717": { "compartment": "compartment_7660", "id": "reaction_10710717", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10672165", "species_5688114" ], "products": [ "species_10710715" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54R66", "DDB_G0283365", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710742": { "compartment": "compartment_7660", "id": "reaction_10710742", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710738", "species_10710729" ], "products": [ "species_10709642", "species_10710740" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q551N8", "DDB_G0276481", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710744": { "compartment": "compartment_7660", "id": "reaction_10710744", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710727", "species_10710719" ], "products": [ "species_10710729" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710722": { "compartment": "compartment_7660", "id": "reaction_10710722", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10710715" ], "products": [ "species_10710719", "species_113541" ], "modifiers": [ [ "species_10710715", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10683780": { "compartment": "compartment_70101", "id": "reaction_10683780", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_29372", "species_10683777" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10722650": { "compartment": "compartment_984", "id": "reaction_10722650", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10722647", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10684783": { "compartment": "compartment_876", "id": "reaction_10684783", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10684780", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "Q559N7", "DDB_G0272550", "Q559I6", "DDB_G0272550", "Q55G06", "DDB_G0272550" ] }, "reaction_10724565": { "compartment": "compartment_7660", "id": "reaction_10724565", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10724563": { "compartment": "compartment_7660", "id": "reaction_10724563", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674840" ], "products": [ "species_10674840", "species_164121", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10675549": { "compartment": "compartment_7660", "id": "reaction_10675549", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674909" ], "products": [ "species_10675547", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674983": { "compartment": "compartment_7660", "id": "reaction_10674983", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674840", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674868": { "compartment": "compartment_7660", "id": "reaction_10674868", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674862" ], "products": [ "species_10674866" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674878": { "compartment": "compartment_7660", "id": "reaction_10674878", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674866" ], "products": [ "species_10674874" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10676040": { "compartment": "compartment_7660", "id": "reaction_10676040", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10675547" ], "products": [ "species_113541", "species_10675584" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674911": { "compartment": "compartment_7660", "id": "reaction_10674911", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674880" ], "products": [ "species_10674193", "species_10674181", "species_113541", "species_10674110", "species_10674909" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674876": { "compartment": "compartment_7660", "id": "reaction_10674876", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674874" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10683703": { "compartment": "compartment_17951", "id": "reaction_10683703", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683700", "catalyst" ] ], "additional_components": [ "Q55CT6", "DDB_G0288735", "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10683737": { "compartment": "compartment_17951", "id": "reaction_10683737", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683734", "catalyst" ] ], "additional_components": [ "B0G110", "DDB_G0288735", "Q54II1", "DDB_G0288735", "Q54RB0", "DDB_G0283261", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q75JL8", "DDB_G0288735", "species_113596" ] }, "reaction_10683740": { "compartment": "compartment_17951", "id": "reaction_10683740", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683742": { "compartment": "compartment_17951", "id": "reaction_10683742", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10693605": { "compartment": "compartment_70101", "id": "reaction_10693605", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693602", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10680017": { "compartment": "compartment_70101", "id": "reaction_10680017", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10671897": { "compartment": "compartment_70101", "id": "reaction_10671897", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671894", "species_29372" ], "products": [ "species_10671858", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10682008": { "compartment": "compartment_17960", "id": "reaction_10682008", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10675426", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671298": { "compartment": "compartment_5460", "id": "reaction_10671298", "reactome": "R-DDI-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671295", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10723508": { "compartment": "compartment_70101", "id": "reaction_10723508", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10673704": { "compartment": "compartment_70101", "id": "reaction_10673704", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_111627", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_29372", "species_111647" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10723971": { "compartment": "compartment_70101", "id": "reaction_10723971", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10712153": { "compartment": "compartment_70101", "id": "reaction_10712153", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10712150", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10684856": { "compartment": "compartment_70101", "id": "reaction_10684856", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10684853", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343" ] }, "reaction_10682020": { "compartment": "compartment_12045", "id": "reaction_10682020", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686707": { "compartment": "compartment_5460", "id": "reaction_10686707", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_30004" ], "products": [ "species_573404", "species_113526" ], "modifiers": [ [ "species_10671343", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10671725": { "compartment": "compartment_70101", "id": "reaction_10671725", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10671722", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10674017": { "compartment": "compartment_70101", "id": "reaction_10674017", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10698613": { "compartment": "compartment_70101", "id": "reaction_10698613", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698610", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10678886" ], "modifiers": [ [ "species_10698610", "catalyst" ] ], "additional_components": [ "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10711102": { "compartment": "compartment_70101", "id": "reaction_10711102", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671129": { "compartment": "compartment_5460", "id": "reaction_10671129", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10699261": { "compartment": "compartment_70101", "id": "reaction_10699261", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699205" ], "products": [ "species_110096", "species_10699258" ], "modifiers": [ [ "species_10699205", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10724003": { "compartment": "compartment_70101", "id": "reaction_10724003", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10673836": { "compartment": "compartment_70101", "id": "reaction_10673836", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10673833", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671521": { "compartment": "compartment_5460", "id": "reaction_10671521", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10671518", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10723948": { "compartment": "compartment_70101", "id": "reaction_10723948", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693658": { "compartment": "compartment_70101", "id": "reaction_10693658", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629739", "species_29356" ], "products": [ "species_1629753", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10723952": { "compartment": "compartment_70101", "id": "reaction_10723952", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679959": { "compartment": "compartment_70101", "id": "reaction_10679959", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_76194", "species_29370" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10677355": { "compartment": "compartment_70101", "id": "reaction_10677355", "reactome": "R-DDI-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10671760", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10693645": { "compartment": "compartment_70101", "id": "reaction_10693645", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10693642", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "species_29926", "Q54CH3", "DDB_G0292920" ] }, "reaction_10724042": { "compartment": "compartment_70101", "id": "reaction_10724042", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723997": { "compartment": "compartment_70101", "id": "reaction_10723997", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024012", "species_29368" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10693628": { "compartment": "compartment_7660", "id": "reaction_10693628", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10697783": { "compartment": "compartment_70101", "id": "reaction_10697783", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10696210": { "compartment": "compartment_70101", "id": "reaction_10696210", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10696207", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671658": { "compartment": "compartment_70101", "id": "reaction_10671658", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10671655", "catalyst" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10683688": { "compartment": "compartment_17951", "id": "reaction_10683688", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693703": { "compartment": "compartment_12045", "id": "reaction_10693703", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10693700", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "species_74016", "Q54K50", "DDB_G0287649", "Q02158", "DDB_G0292736" ] }, "reaction_10724425": { "compartment": "compartment_17963", "id": "reaction_10724425", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10716913": { "compartment": "compartment_17957", "id": "reaction_10716913", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10716907" ], "products": [ "species_10716911" ], "modifiers": [], "additional_components": [ "species_164991", "CHEBI:61907", "DDB_G0270658", "species_164991", "CHEBI:61907", "Q5FXM5", "DDB_G0270658" ] }, "reaction_10682071": { "compartment": "compartment_17960", "id": "reaction_10682071", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10699251": { "compartment": "compartment_70101", "id": "reaction_10699251", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699246" ], "products": [ "species_110096", "species_10699248" ], "modifiers": [ [ "species_10699246", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10723985": { "compartment": "compartment_70101", "id": "reaction_10723985", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10711963": { "compartment": "compartment_5460", "id": "reaction_10711963", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709959", "species_10711952" ], "products": [ "species_10711955", "species_10711950" ], "modifiers": [ [ "species_10711960", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10674313": { "compartment": "compartment_5460", "id": "reaction_10674313", "reactome": "R-DDI-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10671390": { "compartment": "compartment_70101", "id": "reaction_10671390", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10671387", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10714313": { "compartment": "compartment_70101", "id": "reaction_10714313", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799540", "species_29356" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10714310", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10722598": { "compartment": "compartment_70101", "id": "reaction_10722598", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10722595", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10675543": { "compartment": "compartment_12045", "id": "reaction_10675543", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686661": { "compartment": "compartment_5460", "id": "reaction_10686661", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113557" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10686658", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10709689": { "compartment": "compartment_70101", "id": "reaction_10709689", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10709686", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10721205": { "compartment": "compartment_5460", "id": "reaction_10721205", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721196", "species_10721184" ], "products": [ "species_10721182", "species_10721198" ], "modifiers": [ [ "species_10721203", "catalyst" ] ], "additional_components": [ "Q54P40", "DDB_G0284809", "Q54VS1", "DDB_G0280173", "CHEBI:33739", "Q555C8", "DDB_G0274657", "DDB_G0274657", "Q54P40", "DDB_G0284809", "CHEBI:49883", "Q54VS1", "DDB_G0280173", "DDB_G0280889" ] }, "reaction_10721413": { "compartment": "compartment_70101", "id": "reaction_10721413", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10721410", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10673730": { "compartment": "compartment_70101", "id": "reaction_10673730", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10673727", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10675882": { "compartment": "compartment_70101", "id": "reaction_10675882", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10675879", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10715965": { "compartment": "compartment_17951", "id": "reaction_10715965", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10715962", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10671413": { "compartment": "compartment_5460", "id": "reaction_10671413", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671410", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10724451": { "compartment": "compartment_17963", "id": "reaction_10724451", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10724448", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671288": { "compartment": "compartment_5460", "id": "reaction_10671288", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10671285", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10679946": { "compartment": "compartment_70101", "id": "reaction_10679946", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_196778", "species_111294" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10674328": { "compartment": "compartment_70101", "id": "reaction_10674328", "reactome": "R-DDI-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10674325", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10679969": { "compartment": "compartment_70101", "id": "reaction_10679969", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10679966", "catalyst" ] ], "additional_components": [ "Q54Y51", "DDB_G0278413", "species_76629" ] }, "reaction_10699233": { "compartment": "compartment_70101", "id": "reaction_10699233", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699228" ], "products": [ "species_110096", "species_10699230" ], "modifiers": [ [ "species_10699228", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10710929": { "compartment": "compartment_5460", "id": "reaction_10710929", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10710926", "catalyst" ] ], "additional_components": [ "species_113596", "Q86H28", "DDB_G0275669" ] }, "reaction_10686182": { "compartment": "compartment_70101", "id": "reaction_10686182", "reactome": "R-DDI-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686180" ], "products": [ "species_76577", "species_10671835" ], "modifiers": [], "additional_components": [ "species_76577", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123" ] }, "reaction_10693497": { "compartment": "compartment_70101", "id": "reaction_10693497", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10683752": { "compartment": "compartment_17951", "id": "reaction_10683752", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10714363": { "compartment": "compartment_70101", "id": "reaction_10714363", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10714360", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10680566": { "compartment": "compartment_70101", "id": "reaction_10680566", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10675479": { "compartment": "compartment_17960", "id": "reaction_10675479", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723977": { "compartment": "compartment_70101", "id": "reaction_10723977", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724007": { "compartment": "compartment_70101", "id": "reaction_10724007", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10721165": { "compartment": "compartment_5668575", "id": "reaction_10721165", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10721162", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10693637": { "compartment": "compartment_70101", "id": "reaction_10693637", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10684814": { "compartment": "compartment_70101", "id": "reaction_10684814", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10684811", "catalyst" ] ], "additional_components": [ "DDB_G0272883" ] }, "reaction_10693748": { "compartment": "compartment_17957", "id": "reaction_10693748", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_2564836", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10671078": { "compartment": "compartment_5460", "id": "reaction_10671078", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113559" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10671075", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10685049": { "compartment": "compartment_20699", "id": "reaction_10685049", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10685046", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10703426": { "compartment": "compartment_5668575", "id": "reaction_10703426", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ], [ "species_10703424", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901", "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10680347": { "compartment": "compartment_70101", "id": "reaction_10680347", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10671753": { "compartment": "compartment_70101", "id": "reaction_10671753", "reactome": "R-DDI-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10671750", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10726112": { "compartment": "compartment_70101", "id": "reaction_10726112", "reactome": "R-DDI-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671880": { "compartment": "compartment_70101", "id": "reaction_10671880", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671860" ], "products": [ "species_10671872" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10686823": { "compartment": "compartment_70101", "id": "reaction_10686823", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10686820", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680968": { "compartment": "compartment_876", "id": "reaction_10680968", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680926" ], "products": [ "species_10680966" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "Q55DU4", "DDB_G0270882", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10693648": { "compartment": "compartment_7660", "id": "reaction_10693648", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10675760": { "compartment": "compartment_70101", "id": "reaction_10675760", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10675757", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10671328": { "compartment": "compartment_5460", "id": "reaction_10671328", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10670934": { "compartment": "compartment_70101", "id": "reaction_10670934", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670857", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10673994": { "compartment": "compartment_70101", "id": "reaction_10673994", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10673991", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10709701": { "compartment": "compartment_70101", "id": "reaction_10709701", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10709698", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10695694": { "compartment": "compartment_17957", "id": "reaction_10695694", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10720506": { "compartment": "compartment_17927", "id": "reaction_10720506", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10720503", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10696226": { "compartment": "compartment_70101", "id": "reaction_10696226", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10696205", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10686641": { "compartment": "compartment_5460", "id": "reaction_10686641", "reactome": "R-DDI-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10686636", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10675638": { "compartment": "compartment_5460", "id": "reaction_10675638", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10681876": { "compartment": "compartment_984", "id": "reaction_10681876", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682157": { "compartment": "compartment_17960", "id": "reaction_10682157", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10682154", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_29926", "species_113596" ] }, "reaction_10721652": { "compartment": "compartment_70101", "id": "reaction_10721652", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10721649", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10684867": { "compartment": "compartment_70101", "id": "reaction_10684867", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10695696": { "compartment": "compartment_17957", "id": "reaction_10695696", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10723999": { "compartment": "compartment_70101", "id": "reaction_10723999", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10723957": { "compartment": "compartment_70101", "id": "reaction_10723957", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10695732": { "compartment": "compartment_17951", "id": "reaction_10695732", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10723050": { "compartment": "compartment_70101", "id": "reaction_10723050", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10723047", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671234": { "compartment": "compartment_70101", "id": "reaction_10671234", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_508182", "species_29406" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10671231", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10699196": { "compartment": "compartment_70101", "id": "reaction_10699196", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699191", "species_29410" ], "products": [ "species_110096", "species_10699193" ], "modifiers": [ [ "species_10699191", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10674368": { "compartment": "compartment_70101", "id": "reaction_10674368", "reactome": "R-DDI-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10724001": { "compartment": "compartment_70101", "id": "reaction_10724001", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10671162": { "compartment": "compartment_5460", "id": "reaction_10671162", "reactome": "R-DDI-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10671159", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10686188": { "compartment": "compartment_70101", "id": "reaction_10686188", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671907", "species_29372" ], "products": [ "species_10686186", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10679997": { "compartment": "compartment_70101", "id": "reaction_10679997", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10679994", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10723963": { "compartment": "compartment_70101", "id": "reaction_10723963", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693754": { "compartment": "compartment_7660", "id": "reaction_10693754", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10723967": { "compartment": "compartment_70101", "id": "reaction_10723967", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10677343": { "compartment": "compartment_7660", "id": "reaction_10677343", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10677337" ], "products": [ "species_10677341" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "species_76577", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683676": { "compartment": "compartment_17951", "id": "reaction_10683676", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10683673", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10686149": { "compartment": "compartment_5460", "id": "reaction_10686149", "reactome": "R-DDI-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113521", "species_113588" ], "modifiers": [ [ "species_10671466", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10690281": { "compartment": "compartment_70101", "id": "reaction_10690281", "reactome": "R-DDI-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10690061", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10711007": { "compartment": "compartment_70101", "id": "reaction_10711007", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247904", "species_1247942" ], "modifiers": [ [ "species_10711004", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10681902": { "compartment": "compartment_984", "id": "reaction_10681902", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10695730": { "compartment": "compartment_17951", "id": "reaction_10695730", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683611": { "compartment": "compartment_17947", "id": "reaction_10683611", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_76577", "species_389573" ], "modifiers": [ [ "species_10683608", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10695728": { "compartment": "compartment_17951", "id": "reaction_10695728", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10676860": { "compartment": "compartment_17957", "id": "reaction_10676860", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10688234": { "compartment": "compartment_70101", "id": "reaction_10688234", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10702349": { "compartment": "compartment_70101", "id": "reaction_10702349", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10702346", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "Q54VU3", "DDB_G0280135", "species_74126", "species_29926" ] }, "reaction_10675481": { "compartment": "compartment_17957", "id": "reaction_10675481", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10683691": { "compartment": "compartment_17951", "id": "reaction_10683691", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693572": { "compartment": "compartment_70101", "id": "reaction_10693572", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10710360": { "compartment": "compartment_12045", "id": "reaction_10710360", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10710357", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10695709": { "compartment": "compartment_12045", "id": "reaction_10695709", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046059", "species_2046066", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046057" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10679396": { "compartment": "compartment_70101", "id": "reaction_10679396", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10681911": { "compartment": "compartment_984", "id": "reaction_10681911", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682079": { "compartment": "compartment_17960", "id": "reaction_10682079", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10682076", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723983": { "compartment": "compartment_70101", "id": "reaction_10723983", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10724034": { "compartment": "compartment_70101", "id": "reaction_10724034", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10681891": { "compartment": "compartment_70101", "id": "reaction_10681891", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10681888", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10681909": { "compartment": "compartment_984", "id": "reaction_10681909", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10696183": { "compartment": "compartment_12045", "id": "reaction_10696183", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723085": { "compartment": "compartment_5460", "id": "reaction_10723085", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723082", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10721602": { "compartment": "compartment_12045", "id": "reaction_10721602", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10677038", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10698339": { "compartment": "compartment_70101", "id": "reaction_10698339", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698337" ], "products": [ "species_111294", "species_10674851", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10726109": { "compartment": "compartment_70101", "id": "reaction_10726109", "reactome": "R-DDI-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10719211": { "compartment": "compartment_70101", "id": "reaction_10719211", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10723061": { "compartment": "compartment_5460", "id": "reaction_10723061", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29376", "species_29362", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723058", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671715": { "compartment": "compartment_70101", "id": "reaction_10671715", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10671712", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10686653": { "compartment": "compartment_70101", "id": "reaction_10686653", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10686650", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671318": { "compartment": "compartment_5460", "id": "reaction_10671318", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10671315", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10693615": { "compartment": "compartment_70101", "id": "reaction_10693615", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10693612", "catalyst" ] ], "additional_components": [ "Q54N49", "DDB_G0285505", "species_29360" ] }, "reaction_10688232": { "compartment": "compartment_70101", "id": "reaction_10688232", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10698532": { "compartment": "compartment_70101", "id": "reaction_10698532", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3000241" ], "products": [ "species_29366", "species_10698529" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10723981": { "compartment": "compartment_70101", "id": "reaction_10723981", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671400": { "compartment": "compartment_5460", "id": "reaction_10671400", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10682460": { "compartment": "compartment_984", "id": "reaction_10682460", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10671191": { "compartment": "compartment_70101", "id": "reaction_10671191", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10671188", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10698522": { "compartment": "compartment_984", "id": "reaction_10698522", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10698519", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10697451": { "compartment": "compartment_70101", "id": "reaction_10697451", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357707", "species_29356" ], "products": [ "species_5357652", "species_111294", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10696223": { "compartment": "compartment_70101", "id": "reaction_10696223", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10696220", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10700265": { "compartment": "compartment_5460", "id": "reaction_10700265", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29444", "species_29582" ], "modifiers": [ [ "species_10700262", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10693640": { "compartment": "compartment_17957", "id": "reaction_10693640", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2024002", "species_113519" ], "products": [ "species_2024016", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10710309": { "compartment": "compartment_12045", "id": "reaction_10710309", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10710306", "catalyst" ] ], "additional_components": [ "Q54K22", "DDB_G0287631", "species_29926" ] }, "reaction_10673698": { "compartment": "compartment_70101", "id": "reaction_10673698", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111628" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10700271": { "compartment": "compartment_70101", "id": "reaction_10700271", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10700269" ], "products": [ "species_111294", "species_76577", "species_10680480" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10723954": { "compartment": "compartment_70101", "id": "reaction_10723954", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10720818": { "compartment": "compartment_70101", "id": "reaction_10720818", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10680482", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10698619": { "compartment": "compartment_70101", "id": "reaction_10698619", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10678890" ], "products": [ "species_111355", "species_10678886" ], "modifiers": [ [ "species_10678890", "catalyst" ] ], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260" ] }, "reaction_10682098": { "compartment": "compartment_12045", "id": "reaction_10682098", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682458": { "compartment": "compartment_70101", "id": "reaction_10682458", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10682455", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10680568": { "compartment": "compartment_70616", "id": "reaction_10680568", "reactome": "R-DDI-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10680551", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10679324": { "compartment": "compartment_17927", "id": "reaction_10679324", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189411", "species_189461" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10679321", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10691612": { "compartment": "compartment_70101", "id": "reaction_10691612", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_1474179" ], "products": [ "species_29366", "species_29870" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10696267": { "compartment": "compartment_5460", "id": "reaction_10696267", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162256", "species_2162257" ], "products": [ "species_2162214", "species_159450" ], "modifiers": [ [ "species_10696264", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10682136": { "compartment": "compartment_17960", "id": "reaction_10682136", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10682133", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10680561": { "compartment": "compartment_5460", "id": "reaction_10680561", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10680558", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10724013": { "compartment": "compartment_70101", "id": "reaction_10724013", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10695777": { "compartment": "compartment_161320", "id": "reaction_10695777", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10684878": { "compartment": "compartment_70101", "id": "reaction_10684878", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10686902": { "compartment": "compartment_20699", "id": "reaction_10686902", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10686899", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10671498": { "compartment": "compartment_5460", "id": "reaction_10671498", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10671495", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120", "species_113596" ] }, "reaction_10696163": { "compartment": "compartment_70101", "id": "reaction_10696163", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:34784", "species_8942209", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10672066": { "compartment": "compartment_70101", "id": "reaction_10672066", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10672063", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q551Y6", "DDB_G0276253", "Q54SI2", "DDB_G0282759" ] }, "reaction_10671912": { "compartment": "compartment_70101", "id": "reaction_10671912", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671872" ], "products": [ "species_10671909", "species_70113" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10671745": { "compartment": "compartment_70101", "id": "reaction_10671745", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10672030": { "compartment": "compartment_5460", "id": "reaction_10672030", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10672027", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10682478": { "compartment": "compartment_70101", "id": "reaction_10682478", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10682475", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10692500": { "compartment": "compartment_161320", "id": "reaction_10692500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10675875": { "compartment": "compartment_70101", "id": "reaction_10675875", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "species_109395", "species_76577", "CHEBI:57566", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10677058": { "compartment": "compartment_17957", "id": "reaction_10677058", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714825": { "compartment": "compartment_5460", "id": "reaction_10714825", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10674952": { "compartment": "compartment_70101", "id": "reaction_10674952", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10674947", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10686709": { "compartment": "compartment_5460", "id": "reaction_10686709", "reactome": "R-DDI-508561", "name": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_70951" ], "products": [ "species_113594", "species_508531" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10722779": { "compartment": "compartment_70101", "id": "reaction_10722779", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10697437": { "compartment": "compartment_5460", "id": "reaction_10697437", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697433", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10697431" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "Q54KG7", "DDB_G0287353", "species_31649" ] }, "reaction_10718732": { "compartment": "compartment_7660", "id": "reaction_10718732", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10718729", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_29426", "B0G107", "DDB_G0272484" ] }, "reaction_10678919": { "compartment": "compartment_70101", "id": "reaction_10678919", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10678916", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_29926", "Q54E83", "DDB_G0291756" ] }, "reaction_10693477": { "compartment": "compartment_70101", "id": "reaction_10693477", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693474", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q54TI0", "DDB_G0281737", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10680035": { "compartment": "compartment_70101", "id": "reaction_10680035", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10680032", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10674320": { "compartment": "compartment_5460", "id": "reaction_10674320", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500224", "species_113593" ], "products": [ "species_500222", "species_113581" ], "modifiers": [ [ "species_10674317", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_9731659", "species_109386", "Q54YL2", "DDB_G0278191" ] }, "reaction_10695691": { "compartment": "compartment_12045", "id": "reaction_10695691", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10724428": { "compartment": "compartment_17963", "id": "reaction_10724428", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10684911": { "compartment": "compartment_70101", "id": "reaction_10684911", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10680200": { "compartment": "compartment_876", "id": "reaction_10680200", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10680197", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10693588": { "compartment": "compartment_7660", "id": "reaction_10693588", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10693585", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10723989": { "compartment": "compartment_70101", "id": "reaction_10723989", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676821": { "compartment": "compartment_70101", "id": "reaction_10676821", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500606", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500608" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710344": { "compartment": "compartment_5460", "id": "reaction_10710344", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10710341", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10723965": { "compartment": "compartment_70101", "id": "reaction_10723965", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_29364", "species_9024768" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676025": { "compartment": "compartment_70101", "id": "reaction_10676025", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10673723", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10721370": { "compartment": "compartment_70101", "id": "reaction_10721370", "reactome": "R-DDI-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73473", "species_70106", "species_8936443" ], "products": [ "species_29360", "species_29468", "species_29356" ], "modifiers": [ [ "species_10721367", "catalyst" ] ], "additional_components": [ "Q8MYE6", "DDB_G0288165", "Q54YY9", "DDB_G0288165", "CHEBI:21437", "Q55D22", "DDB_G0288165", "Q54NC1", "DDB_G0285399", "Q54JB6", "DDB_G0288165" ] }, "reaction_10674006": { "compartment": "compartment_70101", "id": "reaction_10674006", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10674001", "catalyst" ], [ "species_10674004", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10670908": { "compartment": "compartment_70101", "id": "reaction_10670908", "reactome": "R-DDI-70355", "name": "GALK1 phosphorylates Gal to Gal1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29590" ], "products": [ "species_29370", "species_30170" ], "modifiers": [ [ "species_10670905", "catalyst" ] ], "additional_components": [ "DDB_G0293982" ] }, "reaction_10693763": { "compartment": "compartment_7660", "id": "reaction_10693763", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10724764": { "compartment": "compartment_70101", "id": "reaction_10724764", "reactome": "R-DDI-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10724761", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10710906": { "compartment": "compartment_17951", "id": "reaction_10710906", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10710903", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10680546": { "compartment": "compartment_70101", "id": "reaction_10680546", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10680543", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10677056": { "compartment": "compartment_17957", "id": "reaction_10677056", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10688530": { "compartment": "compartment_70101", "id": "reaction_10688530", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10688527", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10676802": { "compartment": "compartment_17957", "id": "reaction_10676802", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10676799", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10671798": { "compartment": "compartment_5460", "id": "reaction_10671798", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10680053": { "compartment": "compartment_70101", "id": "reaction_10680053", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10715958": { "compartment": "compartment_17951", "id": "reaction_10715958", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10715955", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10679114": { "compartment": "compartment_70101", "id": "reaction_10679114", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10679111", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10682726": { "compartment": "compartment_5460", "id": "reaction_10682726", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10682723", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10711203": { "compartment": "compartment_70101", "id": "reaction_10711203", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10711200", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10704741": { "compartment": "compartment_70101", "id": "reaction_10704741", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10704738", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10672020": { "compartment": "compartment_70101", "id": "reaction_10672020", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10672017", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10688136": { "compartment": "compartment_70101", "id": "reaction_10688136", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688120", "species_111707" ], "products": [ "species_10688125", "species_29432" ], "modifiers": [ [ "species_10688133", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "species_29426", "Q55FS0", "DDB_G0267980", "Q54X04", "DDB_G0279287" ] }, "reaction_10709886": { "compartment": "compartment_17957", "id": "reaction_10709886", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10709883", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10670844": { "compartment": "compartment_70101", "id": "reaction_10670844", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10670841", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759" ] }, "reaction_10672002": { "compartment": "compartment_5460", "id": "reaction_10672002", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10673770": { "compartment": "compartment_70101", "id": "reaction_10673770", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_29370", "species_500828" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "species_109395", "CHEBI:57566", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684957": { "compartment": "compartment_70101", "id": "reaction_10684957", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10722590": { "compartment": "compartment_12045", "id": "reaction_10722590", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10722587", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10676096": { "compartment": "compartment_70101", "id": "reaction_10676096", "reactome": "R-DDI-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676093", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10692454": { "compartment": "compartment_70101", "id": "reaction_10692454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10692451", "catalyst" ] ], "additional_components": [ "species_71185", "P46794", "DDB_G0267386" ] }, "reaction_10715520": { "compartment": "compartment_5460", "id": "reaction_10715520", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10715517", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10693661": { "compartment": "compartment_70101", "id": "reaction_10693661", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10686703": { "compartment": "compartment_5460", "id": "reaction_10686703", "reactome": "R-DDI-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10671265", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10723975": { "compartment": "compartment_70101", "id": "reaction_10723975", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10680223": { "compartment": "compartment_70101", "id": "reaction_10680223", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10680209" ], "products": [ "species_10680207", "species_198816" ], "modifiers": [ [ "species_10680209", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "species_71185", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185" ] }, "reaction_10717979": { "compartment": "compartment_161320", "id": "reaction_10717979", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10717976", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10675545": { "compartment": "compartment_17960", "id": "reaction_10675545", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724271": { "compartment": "compartment_161320", "id": "reaction_10724271", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724258", "species_1605715" ], "products": [ "species_10724262", "species_1605745" ], "modifiers": [ [ "species_10724268", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q55D50", "DDB_G0269790" ] }, "reaction_10720745": { "compartment": "compartment_70101", "id": "reaction_10720745", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10720742", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10692480": { "compartment": "compartment_70101", "id": "reaction_10692480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10674980": { "compartment": "compartment_70101", "id": "reaction_10674980", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10674977", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10722463": { "compartment": "compartment_70101", "id": "reaction_10722463", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10670855", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671252": { "compartment": "compartment_5460", "id": "reaction_10671252", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10671249", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10710331": { "compartment": "compartment_876", "id": "reaction_10710331", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10710328", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10679372": { "compartment": "compartment_5460", "id": "reaction_10679372", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_159549", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10679369", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10673780": { "compartment": "compartment_70101", "id": "reaction_10673780", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10673777", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10676863": { "compartment": "compartment_70101", "id": "reaction_10676863", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10673691": { "compartment": "compartment_70101", "id": "reaction_10673691", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10721497": { "compartment": "compartment_70101", "id": "reaction_10721497", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10682084": { "compartment": "compartment_17960", "id": "reaction_10682084", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10682081", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671096": { "compartment": "compartment_70101", "id": "reaction_10671096", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10671093", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10671707": { "compartment": "compartment_70101", "id": "reaction_10671707", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10671704", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10680536": { "compartment": "compartment_70101", "id": "reaction_10680536", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10688230": { "compartment": "compartment_70101", "id": "reaction_10688230", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10696171": { "compartment": "compartment_12045", "id": "reaction_10696171", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10675538", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10711236": { "compartment": "compartment_5460", "id": "reaction_10711236", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10711233", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0292730" ] }, "reaction_10723036": { "compartment": "compartment_5460", "id": "reaction_10723036", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10723033", "catalyst" ] ], "additional_components": [ "Q86I22", "DDB_G0275071", "species_29926" ] }, "reaction_10699305": { "compartment": "compartment_70101", "id": "reaction_10699305", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699303" ], "products": [ "species_10698514" ], "modifiers": [], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10695735": { "compartment": "compartment_17951", "id": "reaction_10695735", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10671459": { "compartment": "compartment_5460", "id": "reaction_10671459", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10671456", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10722403": { "compartment": "compartment_70101", "id": "reaction_10722403", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10722400", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "DDB_G0269034" ] }, "reaction_10686147": { "compartment": "compartment_5460", "id": "reaction_10686147", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10671446", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10683581": { "compartment": "compartment_17951", "id": "reaction_10683581", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10683578", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10724011": { "compartment": "compartment_70101", "id": "reaction_10724011", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026034" ], "products": [ "species_29364", "species_9026050" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724015": { "compartment": "compartment_70101", "id": "reaction_10724015", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_29364", "species_9026046" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10690348": { "compartment": "compartment_5460", "id": "reaction_10690348", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10690324", "species_10690337" ], "products": [ "species_10690345", "species_379697", "species_10690339" ], "modifiers": [ [ "species_10690324", "catalyst" ], [ "species_10690337", "catalyst" ] ], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "CHEBI:33739", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10693736": { "compartment": "compartment_876", "id": "reaction_10693736", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693733", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10721406": { "compartment": "compartment_70101", "id": "reaction_10721406", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_8938276" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10721403", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10725648": { "compartment": "compartment_70101", "id": "reaction_10725648", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10678991" ], "products": [ "species_10725644" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10693623": { "compartment": "compartment_7660", "id": "reaction_10693623", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10696160": { "compartment": "compartment_70101", "id": "reaction_10696160", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9032038" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10715539": { "compartment": "compartment_70101", "id": "reaction_10715539", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10715536", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10671308": { "compartment": "compartment_5460", "id": "reaction_10671308", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10682018": { "compartment": "compartment_12045", "id": "reaction_10682018", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10693580": { "compartment": "compartment_70101", "id": "reaction_10693580", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693577", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10688160": { "compartment": "compartment_70101", "id": "reaction_10688160", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10688157", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q54NM6", "DDB_G0285137" ] }, "reaction_10710887": { "compartment": "compartment_70101", "id": "reaction_10710887", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10710884", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10724005": { "compartment": "compartment_70101", "id": "reaction_10724005", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675640": { "compartment": "compartment_5460", "id": "reaction_10675640", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10687061": { "compartment": "compartment_5460", "id": "reaction_10687061", "reactome": "R-DDI-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10687058", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10685398": { "compartment": "compartment_876", "id": "reaction_10685398", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10685395", "catalyst" ] ], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10676087": { "compartment": "compartment_70101", "id": "reaction_10676087", "reactome": "R-DDI-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676084", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10684832": { "compartment": "compartment_70101", "id": "reaction_10684832", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10684819", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10680564": { "compartment": "compartment_70101", "id": "reaction_10680564", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10671362": { "compartment": "compartment_70101", "id": "reaction_10671362", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10671359", "catalyst" ] ], "additional_components": [ "DDB_G0273081" ] }, "reaction_10673986": { "compartment": "compartment_70101", "id": "reaction_10673986", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500071", "species_113592" ], "products": [ "species_500077", "species_29370" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "CHEBI:57673", "species_113578", "species_29420", "CHEBI:58595", "DDB_G0279001" ] }, "reaction_10674020": { "compartment": "compartment_70101", "id": "reaction_10674020", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10671380": { "compartment": "compartment_70101", "id": "reaction_10671380", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10671377", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10716922": { "compartment": "compartment_70101", "id": "reaction_10716922", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716918", "species_164991" ], "products": [ "species_10716920" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "species_164991", "Q54GC8", "DDB_G0290237" ] }, "reaction_10674856": { "compartment": "compartment_70101", "id": "reaction_10674856", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674853", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10710920": { "compartment": "compartment_70101", "id": "reaction_10710920", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10710917", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10671686": { "compartment": "compartment_70101", "id": "reaction_10671686", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10671683", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10724728": { "compartment": "compartment_17957", "id": "reaction_10724728", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10724725", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10671619": { "compartment": "compartment_70101", "id": "reaction_10671619", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10671616", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10714942": { "compartment": "compartment_70101", "id": "reaction_10714942", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10714939", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10671106": { "compartment": "compartment_5460", "id": "reaction_10671106", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "Q54KB7", "DDB_G0287469" ] }, "reaction_10693575": { "compartment": "compartment_70101", "id": "reaction_10693575", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10711211": { "compartment": "compartment_5460", "id": "reaction_10711211", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_6788606" ], "products": [ "species_113525", "species_5696409" ], "modifiers": [ [ "species_10711208", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10671608": { "compartment": "compartment_70101", "id": "reaction_10671608", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10671605", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10674301": { "compartment": "compartment_5460", "id": "reaction_10674301", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10674298", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10693708": { "compartment": "compartment_70101", "id": "reaction_10693708", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693705", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "species_29926" ] }, "reaction_10679054": { "compartment": "compartment_70101", "id": "reaction_10679054", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10679051", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:34479", "species_9753685", "CHEBI:8927", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54YN2", "DDB_G0278155", "Q54C73", "DDB_G0293122" ] }, "reaction_10671539": { "compartment": "compartment_5460", "id": "reaction_10671539", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10671536", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355" ] }, "reaction_10680025": { "compartment": "compartment_70101", "id": "reaction_10680025", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197238" ], "products": [ "species_113528", "species_111294", "species_197220" ], "modifiers": [ [ "species_10680022", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10683763": { "compartment": "compartment_17951", "id": "reaction_10683763", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10685044": { "compartment": "compartment_876", "id": "reaction_10685044", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10685041", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10725886": { "compartment": "compartment_70101", "id": "reaction_10725886", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10684851", "catalyst" ], [ "species_10725884", "inhibitor" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "LigandDisplayForward?ligandId=6625", "Q75JX1", "DDB_G0272350", "LigandDisplayForward?ligandId=10641", "Q86KF9", "DDB_G0272522", "LigandDisplayForward?ligandId=10219", "Q54HN2", "DDB_G0289343", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10687082": { "compartment": "compartment_5460", "id": "reaction_10687082", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_113552", "species_893617" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10725836": { "compartment": "compartment_70101", "id": "reaction_10725836", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674001", "species_9678719" ], "products": [ "species_10674004" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10686178": { "compartment": "compartment_5460", "id": "reaction_10686178", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10686175", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10676068": { "compartment": "compartment_70101", "id": "reaction_10676068", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10676065", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P21900", "DDB_G0285429", "species_29926" ] }, "reaction_10697789": { "compartment": "compartment_70101", "id": "reaction_10697789", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10710603": { "compartment": "compartment_5460", "id": "reaction_10710603", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10679344": { "compartment": "compartment_70101", "id": "reaction_10679344", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_113528", "species_189455" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10679938": { "compartment": "compartment_70101", "id": "reaction_10679938", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10679935", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10724017": { "compartment": "compartment_70101", "id": "reaction_10724017", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10686496": { "compartment": "compartment_70101", "id": "reaction_10686496", "reactome": "R-DDI-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_482627", "species_113592" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10674365": { "compartment": "compartment_70101", "id": "reaction_10674365", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_83956" ], "products": [ "species_30064", "species_31633" ], "modifiers": [ [ "species_10674362", "catalyst" ] ], "additional_components": [ "species_29426", "Q86AW9", "DDB_G0277743" ] }, "reaction_10696240": { "compartment": "compartment_5460", "id": "reaction_10696240", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10723961": { "compartment": "compartment_70101", "id": "reaction_10723961", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10680508": { "compartment": "compartment_7660", "id": "reaction_10680508", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10680505", "catalyst" ] ], "additional_components": [ "species_29426", "Q54IH4", "DDB_G0288757" ] }, "reaction_10671648": { "compartment": "compartment_70101", "id": "reaction_10671648", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10671645", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10687814": { "compartment": "compartment_876", "id": "reaction_10687814", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_71185", "species_29356" ], "products": [ "species_29370", "species_917877", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10723987": { "compartment": "compartment_70101", "id": "reaction_10723987", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024576" ], "products": [ "species_29364", "species_9024577" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675483": { "compartment": "compartment_17960", "id": "reaction_10675483", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696181": { "compartment": "compartment_70101", "id": "reaction_10696181", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142718" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10698333": { "compartment": "compartment_70101", "id": "reaction_10698333", "reactome": "R-DDI-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10698327", "species_113592" ], "products": [ "species_10698331", "species_111294", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "DDB_G0288791" ] }, "reaction_10693566": { "compartment": "compartment_17957", "id": "reaction_10693566", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10688246": { "compartment": "compartment_70101", "id": "reaction_10688246", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10690084": { "compartment": "compartment_70101", "id": "reaction_10690084", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10690081", "catalyst" ] ], "additional_components": [ "Q55FM6", "DDB_G0268036", "species_29926" ] }, "reaction_10675840": { "compartment": "compartment_70101", "id": "reaction_10675840", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10675837", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10680494": { "compartment": "compartment_70101", "id": "reaction_10680494", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680482", "species_113592" ], "products": [ "species_29370", "species_10680489" ], "modifiers": [ [ "species_10680491", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10671278": { "compartment": "compartment_5460", "id": "reaction_10671278", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10671275", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10671403": { "compartment": "compartment_5460", "id": "reaction_10671403", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10696251": { "compartment": "compartment_5460", "id": "reaction_10696251", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10684875": { "compartment": "compartment_70101", "id": "reaction_10684875", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025544", "species_29356" ], "products": [ "species_3632878", "species_428237" ], "modifiers": [ [ "species_10684872", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10675569": { "compartment": "compartment_70101", "id": "reaction_10675569", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10675566", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10680928": { "compartment": "compartment_70101", "id": "reaction_10680928", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751", "species_10680924" ], "products": [ "species_10680926" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10714820": { "compartment": "compartment_5460", "id": "reaction_10714820", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693984", "species_113526" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10714931": { "compartment": "compartment_17957", "id": "reaction_10714931", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806656", "species_6806362" ], "modifiers": [ [ "species_10714928", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10675642": { "compartment": "compartment_5460", "id": "reaction_10675642", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10678909": { "compartment": "compartment_70101", "id": "reaction_10678909", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10695699": { "compartment": "compartment_17957", "id": "reaction_10695699", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_162743", "species_2046065", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10671354": { "compartment": "compartment_5460", "id": "reaction_10671354", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671351", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10673701": { "compartment": "compartment_70101", "id": "reaction_10673701", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_111647" ], "products": [ "species_70106", "species_29372", "species_111628" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10673688": { "compartment": "compartment_70101", "id": "reaction_10673688", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10680051": { "compartment": "compartment_70101", "id": "reaction_10680051", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10722428": { "compartment": "compartment_5460", "id": "reaction_10722428", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113553", "species_113559" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10722425", "catalyst" ] ], "additional_components": [ "Q54BP5", "DDB_G0293514", "Q54IG0", "DDB_G0293514" ] }, "reaction_10687093": { "compartment": "compartment_70101", "id": "reaction_10687093", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10725642": { "compartment": "compartment_70101", "id": "reaction_10725642", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10680501": { "compartment": "compartment_5460", "id": "reaction_10680501", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10680498", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10698629": { "compartment": "compartment_5460", "id": "reaction_10698629", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10698626", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10696138": { "compartment": "compartment_984", "id": "reaction_10696138", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_352327", "species_109276" ], "products": [ "species_2160466", "species_2022135", "species_351629" ], "modifiers": [ [ "species_10696135", "catalyst" ] ], "additional_components": [ "Q54EW2", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B17", "DDB_G0293662", "species_113596", "Q55B19", "DDB_G0293662" ] }, "reaction_10723979": { "compartment": "compartment_70101", "id": "reaction_10723979", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679334": { "compartment": "compartment_17927", "id": "reaction_10679334", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10679331", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10671581": { "compartment": "compartment_70101", "id": "reaction_10671581", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10671578", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10690353": { "compartment": "compartment_5460", "id": "reaction_10690353", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690351", "species_113531" ], "products": [ "species_10690324" ], "modifiers": [], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003" ] }, "reaction_10690098": { "compartment": "compartment_70101", "id": "reaction_10690098", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10693526": { "compartment": "compartment_7660", "id": "reaction_10693526", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10711146": { "compartment": "compartment_17951", "id": "reaction_10711146", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10711143", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10699208": { "compartment": "compartment_70101", "id": "reaction_10699208", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699203", "species_29410" ], "products": [ "species_110096", "species_10699205" ], "modifiers": [ [ "species_10699203", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10709111": { "compartment": "compartment_5460", "id": "reaction_10709111", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10709108", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10703158": { "compartment": "compartment_17963", "id": "reaction_10703158", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10703155", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10712054": { "compartment": "compartment_70101", "id": "reaction_10712054", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10712051", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10693739": { "compartment": "compartment_876", "id": "reaction_10693739", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693673", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10693417": { "compartment": "compartment_161320", "id": "reaction_10693417", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105025", "species_1605715" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10699242": { "compartment": "compartment_70101", "id": "reaction_10699242", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699230" ], "products": [ "species_10699240" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10704832": { "compartment": "compartment_70101", "id": "reaction_10704832", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10691218", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10724243": { "compartment": "compartment_70101", "id": "reaction_10724243", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10671571": { "compartment": "compartment_5460", "id": "reaction_10671571", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10671568", "catalyst" ] ], "additional_components": [ "species_113596", "Q54R47", "DDB_G0283411" ] }, "reaction_10684954": { "compartment": "compartment_70101", "id": "reaction_10684954", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684951", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10679354": { "compartment": "compartment_70101", "id": "reaction_10679354", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_70106", "species_189464", "species_29356" ], "modifiers": [ [ "species_10679351", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10698535": { "compartment": "compartment_70101", "id": "reaction_10698535", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10687096": { "compartment": "compartment_70101", "id": "reaction_10687096", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10724430": { "compartment": "compartment_17963", "id": "reaction_10724430", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671336": { "compartment": "compartment_5460", "id": "reaction_10671336", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10671333", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10682091": { "compartment": "compartment_12045", "id": "reaction_10682091", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10681868": { "compartment": "compartment_70101", "id": "reaction_10681868", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10681865", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10688113": { "compartment": "compartment_70101", "id": "reaction_10688113", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10688110", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10690074": { "compartment": "compartment_70101", "id": "reaction_10690074", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10690071", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10671127": { "compartment": "compartment_70101", "id": "reaction_10671127", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10671124", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10699238": { "compartment": "compartment_70101", "id": "reaction_10699238", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699235" ], "products": [ "species_110096", "species_10699228" ], "modifiers": [ [ "species_10699235", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10703431": { "compartment": "compartment_5668572", "id": "reaction_10703431", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10671796": { "compartment": "compartment_5460", "id": "reaction_10671796", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10671793", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q54C70", "DDB_G0292994", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "P36413", "DDB_G0277847", "species_113596" ] }, "reaction_10674059": { "compartment": "compartment_5460", "id": "reaction_10674059", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10674056", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10709082": { "compartment": "compartment_70101", "id": "reaction_10709082", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10709079", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "C7G041", "DDB_G0295733" ] }, "reaction_10686145": { "compartment": "compartment_5462", "id": "reaction_10686145", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10686142", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10722332": { "compartment": "compartment_17963", "id": "reaction_10722332", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10722329", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10671932": { "compartment": "compartment_70101", "id": "reaction_10671932", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10671929", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_74126", "species_29926" ] }, "reaction_10680528": { "compartment": "compartment_70101", "id": "reaction_10680528", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10682074": { "compartment": "compartment_12045", "id": "reaction_10682074", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671151": { "compartment": "compartment_70101", "id": "reaction_10671151", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10671148", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q86HN8", "DDB_G0274501", "Q55E85", "DDB_G0269352" ] }, "reaction_10676819": { "compartment": "compartment_70101", "id": "reaction_10676819", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500605", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500607" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710913": { "compartment": "compartment_5460", "id": "reaction_10710913", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10710910", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10724046": { "compartment": "compartment_70101", "id": "reaction_10724046", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678893": { "compartment": "compartment_70101", "id": "reaction_10678893", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10678886" ], "products": [ "species_174390", "species_10678890" ], "modifiers": [ [ "species_10678886", "catalyst" ] ], "additional_components": [ "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10724009": { "compartment": "compartment_70101", "id": "reaction_10724009", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10683603": { "compartment": "compartment_17951", "id": "reaction_10683603", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10683600", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10703429": { "compartment": "compartment_5668572", "id": "reaction_10703429", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10684902": { "compartment": "compartment_70101", "id": "reaction_10684902", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275", "species_29356" ], "products": [ "species_428694", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10674338": { "compartment": "compartment_70101", "id": "reaction_10674338", "reactome": "R-DDI-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671372": { "compartment": "compartment_70101", "id": "reaction_10671372", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10671369", "catalyst" ] ], "additional_components": [ "Q86AX3", "DDB_G0277727", "species_29360" ] }, "reaction_10723950": { "compartment": "compartment_70101", "id": "reaction_10723950", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671172": { "compartment": "compartment_5460", "id": "reaction_10671172", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10671169", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10682291": { "compartment": "compartment_70101", "id": "reaction_10682291", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_265281", "species_29356" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10673806": { "compartment": "compartment_70101", "id": "reaction_10673806", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10673803", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10671561": { "compartment": "compartment_5460", "id": "reaction_10671561", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10720454": { "compartment": "compartment_70101", "id": "reaction_10720454", "reactome": "R-DDI-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720450" ], "products": [ "species_10720452" ], "modifiers": [], "additional_components": [ "species_8874708", "Q54YX3", "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10721392": { "compartment": "compartment_70101", "id": "reaction_10721392", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10721389", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10693651": { "compartment": "compartment_7660", "id": "reaction_10693651", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10699221": { "compartment": "compartment_70101", "id": "reaction_10699221", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699193" ], "products": [ "species_10699213" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10674042": { "compartment": "compartment_70101", "id": "reaction_10674042", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_113592", "species_111292" ], "products": [ "species_70106", "species_29370", "species_111338", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10697435": { "compartment": "compartment_5460", "id": "reaction_10697435", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690345", "species_10697431" ], "products": [ "species_10697433", "species_10690337", "species_113529" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54KG7", "DDB_G0287353", "species_31649", "Q54KG7", "DDB_G0287353", "species_113596", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10701681": { "compartment": "compartment_70101", "id": "reaction_10701681", "reactome": "R-DDI-5223313", "name": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239", "species_113592", "species_29356" ], "products": [ "species_29370", "species_3000241", "species_29372" ], "modifiers": [ [ "species_10701678", "catalyst" ] ], "additional_components": [ "Q54W20", "DDB_G0279919", "Q54KD1", "DDB_G0287405" ] }, "reaction_10714347": { "compartment": "compartment_161320", "id": "reaction_10714347", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10714344", "catalyst" ] ], "additional_components": [ "Q1ZXI8", "DDB_G0278651", "species_29426", "Q55ER0", "DDB_G0268994", "Q54KN4", "DDB_G0287231", "Q54YF7", "DDB_G0278259", "Q54YC4", "DDB_G0278653", "P34098", "DDB_G0292206" ] }, "reaction_10724753": { "compartment": "compartment_161320", "id": "reaction_10724753", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10682086": { "compartment": "compartment_12045", "id": "reaction_10682086", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671697": { "compartment": "compartment_70101", "id": "reaction_10671697", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10671694", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10679394": { "compartment": "compartment_70101", "id": "reaction_10679394", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10679351" ], "products": [ "species_29426", "species_10679392" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_190173" ] }, "reaction_10699256": { "compartment": "compartment_70101", "id": "reaction_10699256", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699253" ], "products": [ "species_10699191", "species_110096" ], "modifiers": [ [ "species_10699253", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10696176": { "compartment": "compartment_12045", "id": "reaction_10696176", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10696173", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724757": { "compartment": "compartment_161320", "id": "reaction_10724757", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10724423": { "compartment": "compartment_17963", "id": "reaction_10724423", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10724420", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10675485": { "compartment": "compartment_17960", "id": "reaction_10675485", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671513": { "compartment": "compartment_5460", "id": "reaction_10671513", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10671510", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10710932": { "compartment": "compartment_5460", "id": "reaction_10710932", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10696197": { "compartment": "compartment_70101", "id": "reaction_10696197", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10696194", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10678954": { "compartment": "compartment_17957", "id": "reaction_10678954", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174932" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10678951", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:32663", "CHEBI:63860", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714406": { "compartment": "compartment_12045", "id": "reaction_10714406", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10714399", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10684913": { "compartment": "compartment_70101", "id": "reaction_10684913", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10709894": { "compartment": "compartment_12045", "id": "reaction_10709894", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10709891", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10671086": { "compartment": "compartment_5460", "id": "reaction_10671086", "reactome": "R-DDI-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10671083", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "DDB_G0276335" ] }, "reaction_10716029": { "compartment": "compartment_17951", "id": "reaction_10716029", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10716026", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10674970": { "compartment": "compartment_70101", "id": "reaction_10674970", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10674967", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10685912": { "compartment": "compartment_5460", "id": "reaction_10685912", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10685909", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10690108": { "compartment": "compartment_70101", "id": "reaction_10690108", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10690105", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10682289": { "compartment": "compartment_70101", "id": "reaction_10682289", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10680220": { "compartment": "compartment_70101", "id": "reaction_10680220", "reactome": "R-DDI-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10680207" ], "products": [ "species_29360", "species_10680209" ], "modifiers": [ [ "species_10680217", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185", "Q54NC1", "DDB_G0285399", "species_113596" ] }, "reaction_10682255": { "compartment": "compartment_70101", "id": "reaction_10682255", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10712062": { "compartment": "compartment_5460", "id": "reaction_10712062", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10712059", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10687099": { "compartment": "compartment_70101", "id": "reaction_10687099", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10673790": { "compartment": "compartment_70101", "id": "reaction_10673790", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10673787", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10706110": { "compartment": "compartment_12045", "id": "reaction_10706110", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10706107", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10693680": { "compartment": "compartment_876", "id": "reaction_10693680", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693677", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10692503": { "compartment": "compartment_161320", "id": "reaction_10692503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10682468": { "compartment": "compartment_70101", "id": "reaction_10682468", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10724731": { "compartment": "compartment_17957", "id": "reaction_10724731", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677009", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10671242": { "compartment": "compartment_5460", "id": "reaction_10671242", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10671239", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10683593": { "compartment": "compartment_17951", "id": "reaction_10683593", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10683590", "catalyst" ] ], "additional_components": [ "species_29480", "Q54DA9", "DDB_G0292402", "species_29926" ] }, "reaction_10693745": { "compartment": "compartment_7660", "id": "reaction_10693745", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10671995": { "compartment": "compartment_70101", "id": "reaction_10671995", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10671992", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10671638": { "compartment": "compartment_70101", "id": "reaction_10671638", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10671635", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "species_71067", "species_198816", "Q557J8", "DDB_G0273429" ] }, "reaction_10698616": { "compartment": "compartment_70101", "id": "reaction_10698616", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3149505" ], "products": [ "species_29366", "species_10698529", "species_1130611" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10702271": { "compartment": "compartment_70101", "id": "reaction_10702271", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10719223": { "compartment": "compartment_70101", "id": "reaction_10719223", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10714960": { "compartment": "compartment_5460", "id": "reaction_10714960", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10714957", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10675877": { "compartment": "compartment_70101", "id": "reaction_10675877", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10687069": { "compartment": "compartment_5460", "id": "reaction_10687069", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687066", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10724039": { "compartment": "compartment_70101", "id": "reaction_10724039", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696186": { "compartment": "compartment_70101", "id": "reaction_10696186", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10688519": { "compartment": "compartment_70101", "id": "reaction_10688519", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10688516", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10674355": { "compartment": "compartment_70101", "id": "reaction_10674355", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83921", "CHEBI:17172", "CHEBI:16750", "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10674782": { "compartment": "compartment_70101", "id": "reaction_10674782", "reactome": "R-DDI-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10673675", "catalyst" ] ], "additional_components": [ "species_110096", "species_110094", "CHEBI:58593", "species_109395", "CHEBI:57566", "species_109402", "DDB_G0287495" ] }, "reaction_10724032": { "compartment": "compartment_70101", "id": "reaction_10724032", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10688148": { "compartment": "compartment_70101", "id": "reaction_10688148", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10688145", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10723969": { "compartment": "compartment_70101", "id": "reaction_10723969", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10696146": { "compartment": "compartment_70101", "id": "reaction_10696146", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10671969": { "compartment": "compartment_70101", "id": "reaction_10671969", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10680345": { "compartment": "compartment_876", "id": "reaction_10680345", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10680342", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10697786": { "compartment": "compartment_70101", "id": "reaction_10697786", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10687079": { "compartment": "compartment_70616", "id": "reaction_10687079", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687076", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10683622": { "compartment": "compartment_17951", "id": "reaction_10683622", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10683619", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10673846": { "compartment": "compartment_7660", "id": "reaction_10673846", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10673843", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10698355": { "compartment": "compartment_5460", "id": "reaction_10698355", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10698352", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10712045": { "compartment": "compartment_5460", "id": "reaction_10712045", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10671408", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10679382": { "compartment": "compartment_5460", "id": "reaction_10679382", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10679379", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10723088": { "compartment": "compartment_70101", "id": "reaction_10723088", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10701265", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10725646": { "compartment": "compartment_70101", "id": "reaction_10725646", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725644" ], "products": [ "species_189386", "species_10678991" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10723945": { "compartment": "compartment_70101", "id": "reaction_10723945", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020602", "species_29368" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678931": { "compartment": "compartment_70101", "id": "reaction_10678931", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10678928", "catalyst" ] ], "additional_components": [ "P10819", "DDB_G0267418", "species_29360" ] }, "reaction_10698646": { "compartment": "compartment_70101", "id": "reaction_10698646", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698608", "species_3149479" ], "products": [ "species_10698610" ], "modifiers": [], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10674028": { "compartment": "compartment_70101", "id": "reaction_10674028", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_70106", "species_29370", "species_111370", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680269": { "compartment": "compartment_70616", "id": "reaction_10680269", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10680266", "catalyst" ] ], "additional_components": [ "Q551X6", "DDB_G0276261", "Q54EV4", "DDB_G0291312", "Q54DU1", "DDB_G0292034", "Q54QI8", "DDB_G0283811", "Q54MZ4", "DDB_G0285599" ] }, "reaction_10719220": { "compartment": "compartment_70101", "id": "reaction_10719220", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10693757": { "compartment": "compartment_7660", "id": "reaction_10693757", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10722474": { "compartment": "compartment_70101", "id": "reaction_10722474", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10722471", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10724048": { "compartment": "compartment_70101", "id": "reaction_10724048", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671678": { "compartment": "compartment_70101", "id": "reaction_10671678", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10671675", "catalyst" ] ], "additional_components": [ "Q55DB4", "DDB_G0269714", "species_71185" ] }, "reaction_10682013": { "compartment": "compartment_12045", "id": "reaction_10682013", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10682010", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723991": { "compartment": "compartment_70101", "id": "reaction_10723991", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10702273": { "compartment": "compartment_70101", "id": "reaction_10702273", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78587", "CHEBI:78581", "Q54GA9", "DDB_G0290291" ] }, "reaction_10675822": { "compartment": "compartment_5460", "id": "reaction_10675822", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500822", "species_113593" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10675819", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_500742", "species_109366", "CHEBI:57566", "DDB_G0278191" ] }, "reaction_10719226": { "compartment": "compartment_70101", "id": "reaction_10719226", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10721331": { "compartment": "compartment_70616", "id": "reaction_10721331", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10721320" ], "products": [ "species_29374", "species_10721323" ], "modifiers": [ [ "species_10721328", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10682331": { "compartment": "compartment_70101", "id": "reaction_10682331", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10711938": { "compartment": "compartment_5460", "id": "reaction_10711938", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_10711922" ], "products": [ "species_10709959", "species_10711930" ], "modifiers": [ [ "species_10711935", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287107" ] }, "reaction_10671117": { "compartment": "compartment_5460", "id": "reaction_10671117", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10725639": { "compartment": "compartment_70101", "id": "reaction_10725639", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10703403": { "compartment": "compartment_5668572", "id": "reaction_10703403", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10703400", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10696248": { "compartment": "compartment_70616", "id": "reaction_10696248", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10696245", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10725998": { "compartment": "compartment_70101", "id": "reaction_10725998", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10725995", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10714822": { "compartment": "compartment_5460", "id": "reaction_10714822", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10684864": { "compartment": "compartment_70101", "id": "reaction_10684864", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "DDB_G0269738" ] }, "reaction_10674036": { "compartment": "compartment_70101", "id": "reaction_10674036", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10674033", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10698347": { "compartment": "compartment_5460", "id": "reaction_10698347", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10698344", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10696168": { "compartment": "compartment_12045", "id": "reaction_10696168", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10696165", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682321": { "compartment": "compartment_876", "id": "reaction_10682321", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10675770": { "compartment": "compartment_70101", "id": "reaction_10675770", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500201" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_109386", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684070": { "compartment": "compartment_876", "id": "reaction_10684070", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10684067", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10723505": { "compartment": "compartment_70101", "id": "reaction_10723505", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10683783": { "compartment": "compartment_17947", "id": "reaction_10683783", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10683481", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10679390": { "compartment": "compartment_70101", "id": "reaction_10679390", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10679387", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10699265": { "compartment": "compartment_70101", "id": "reaction_10699265", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699258" ], "products": [ "species_10699263" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10678959": { "compartment": "compartment_17957", "id": "reaction_10678959", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174911" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10678956", "catalyst" ] ], "additional_components": [ "CHEBI:16580", "species_211993", "species_29630", "species_159559", "species_39427", "CHEBI:32649", "species_158604", "CHEBI:65137", "CHEBI:176976", "CHEBI:64681", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10671668": { "compartment": "compartment_70101", "id": "reaction_10671668", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10671665", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10721317": { "compartment": "compartment_70101", "id": "reaction_10721317", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10721306", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10714397": { "compartment": "compartment_70101", "id": "reaction_10714397", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10715501": { "compartment": "compartment_13977", "id": "reaction_10715501", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10715498", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10711244": { "compartment": "compartment_7660", "id": "reaction_10711244", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10711241", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0278493" ] }, "reaction_10671068": { "compartment": "compartment_70101", "id": "reaction_10671068", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10671065", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10720456": { "compartment": "compartment_70101", "id": "reaction_10720456", "reactome": "R-DDI-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874708", "species_10720448" ], "products": [ "species_10720450" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10691374": { "compartment": "compartment_70101", "id": "reaction_10691374", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10691371", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10724050": { "compartment": "compartment_70101", "id": "reaction_10724050", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10723943": { "compartment": "compartment_70101", "id": "reaction_10723943", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10670918": { "compartment": "compartment_70101", "id": "reaction_10670918", "reactome": "R-DDI-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10670915", "catalyst" ] ], "additional_components": [ "Q553X7", "DDB_G0275295", "species_29360" ] }, "reaction_10709876": { "compartment": "compartment_17957", "id": "reaction_10709876", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10679064": { "compartment": "compartment_17957", "id": "reaction_10679064", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:27561", "species_159211", "CHEBI:2505", "species_9753685", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10709696": { "compartment": "compartment_12045", "id": "reaction_10709696", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10709693", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10714952": { "compartment": "compartment_5460", "id": "reaction_10714952", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10714949", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10688509": { "compartment": "compartment_17951", "id": "reaction_10688509", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10688506", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10693760": { "compartment": "compartment_70101", "id": "reaction_10693760", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_1629746", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10674382": { "compartment": "compartment_70101", "id": "reaction_10674382", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q54PM8", "DDB_G0284431" ] }, "reaction_10688244": { "compartment": "compartment_70101", "id": "reaction_10688244", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10680007": { "compartment": "compartment_70101", "id": "reaction_10680007", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10680004", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10698644": { "compartment": "compartment_70101", "id": "reaction_10698644", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10698641", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "Q54FB7", "DDB_G0291047", "species_113596" ] }, "reaction_10693548": { "compartment": "compartment_70101", "id": "reaction_10693548", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_1629741", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10715863": { "compartment": "compartment_17951", "id": "reaction_10715863", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10715860", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10684933": { "compartment": "compartment_984", "id": "reaction_10684933", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10684930", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10693569": { "compartment": "compartment_70101", "id": "reaction_10693569", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10720464": { "compartment": "compartment_5460", "id": "reaction_10720464", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10720461", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10684725": { "compartment": "compartment_876", "id": "reaction_10684725", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10684722", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10686646": { "compartment": "compartment_876", "id": "reaction_10686646", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10686643", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10675490": { "compartment": "compartment_12045", "id": "reaction_10675490", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10675487", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10674039": { "compartment": "compartment_70101", "id": "reaction_10674039", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_70106", "species_111354", "species_111355" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680570": { "compartment": "compartment_70101", "id": "reaction_10680570", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10680556": { "compartment": "compartment_70101", "id": "reaction_10680556", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10693664": { "compartment": "compartment_70101", "id": "reaction_10693664", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10680533": { "compartment": "compartment_876", "id": "reaction_10680533", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10680530", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10680239": { "compartment": "compartment_70101", "id": "reaction_10680239", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10680231" ], "products": [ "species_10674902", "species_158466" ], "modifiers": [ [ "species_10680236", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "DDB_G0285927" ] }, "reaction_10696179": { "compartment": "compartment_70101", "id": "reaction_10696179", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142738", "species_29368" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10670982": { "compartment": "compartment_70101", "id": "reaction_10670982", "reactome": "R-DDI-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10670979", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "P90521", "DDB_G0274111" ] }, "reaction_10680043": { "compartment": "compartment_70101", "id": "reaction_10680043", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10675644": { "compartment": "compartment_5460", "id": "reaction_10675644", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10674311": { "compartment": "compartment_5460", "id": "reaction_10674311", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10674308", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10682486": { "compartment": "compartment_70101", "id": "reaction_10682486", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10682483", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10670870": { "compartment": "compartment_70101", "id": "reaction_10670870", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10670867", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10671223": { "compartment": "compartment_5460", "id": "reaction_10671223", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10671220", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_29480", "Q54EW8", "DDB_G0291648", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_113596", "Q54M22", "DDB_G0286335" ] }, "reaction_10691385": { "compartment": "compartment_70101", "id": "reaction_10691385", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10691382", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10671441": { "compartment": "compartment_5460", "id": "reaction_10671441", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671438", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q54B68", "DDB_G0293872", "Q55BI2", "DDB_G0271344", "species_29418" ] }, "reaction_10702283": { "compartment": "compartment_70101", "id": "reaction_10702283", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10723959": { "compartment": "compartment_70101", "id": "reaction_10723959", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10683750": { "compartment": "compartment_17951", "id": "reaction_10683750", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10723973": { "compartment": "compartment_70101", "id": "reaction_10723973", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10682096": { "compartment": "compartment_12045", "id": "reaction_10682096", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682093", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10717974": { "compartment": "compartment_161320", "id": "reaction_10717974", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10717971", "catalyst" ] ], "additional_components": [ "species_29426", "P34098", "DDB_G0292206" ] }, "reaction_10698294": { "compartment": "compartment_70101", "id": "reaction_10698294", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698280" ], "products": [ "species_111294", "species_10698286", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10679956": { "compartment": "compartment_70101", "id": "reaction_10679956", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10679953", "catalyst" ] ], "additional_components": [ "Q55GR8", "DDB_G0267546", "species_29926" ] }, "reaction_10724025": { "compartment": "compartment_70101", "id": "reaction_10724025", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "CHEBI:137019", "CHEBI:137020", "CHEBI:137018", "CHEBI:137011", "DDB_G0279909" ] }, "reaction_10683754": { "compartment": "compartment_17951", "id": "reaction_10683754", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724044": { "compartment": "compartment_70101", "id": "reaction_10724044", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671591": { "compartment": "compartment_70101", "id": "reaction_10671591", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10671588", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10682470": { "compartment": "compartment_70101", "id": "reaction_10682470", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10699535": { "compartment": "compartment_7660", "id": "reaction_10699535", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_10699531" ], "products": [ "species_10699533" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10685442": { "compartment": "compartment_876", "id": "reaction_10685442", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10685439", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685527": { "compartment": "compartment_70101", "id": "reaction_10685527", "reactome": "R-DDI-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674709", "species_10684045" ], "products": [ "species_10685525" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10685468": { "compartment": "compartment_70101", "id": "reaction_10685468", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683907", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10674822": { "compartment": "compartment_13231", "id": "reaction_10674822", "reactome": "R-DDI-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674810" ], "products": [ "species_10674820" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10674828": { "compartment": "compartment_70101", "id": "reaction_10674828", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674826" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10674824": { "compartment": "compartment_13231", "id": "reaction_10674824", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674806" ], "products": [ "species_10674816" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10720815": { "compartment": "compartment_171062", "id": "reaction_10720815", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720749" ], "products": [ "species_10720472", "species_10720753", "species_29420" ], "modifiers": [ [ "species_10720812", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P34142", "DDB_G0286553", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PZ6", "DDB_G0284213", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721139": { "compartment": "compartment_5668575", "id": "reaction_10721139", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721116", "species_29438" ], "products": [ "species_10720472", "species_10721124", "species_29420" ], "modifiers": [ [ "species_10721136", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MXQ2", "DDB_G0275675", "Q55FM7", "DDB_G0268034", "Q54QR3", "DDB_G0283603", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "species_29438", "Q54QR3", "DDB_G0283603", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10720997": { "compartment": "compartment_17938", "id": "reaction_10720997", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720948" ], "products": [ "species_10720472", "species_10720978", "species_29420" ], "modifiers": [ [ "species_10720994", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q54IQ5", "DDB_G0288589", "Q54TG0", "DDB_G0281773" ] }, "reaction_10720737": { "compartment": "compartment_70101", "id": "reaction_10720737", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720721" ], "products": [ "species_10720472", "species_10720725", "species_29420" ], "modifiers": [ [ "species_10720734", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P36410", "DDB_G0281337", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10721062": { "compartment": "compartment_13946", "id": "reaction_10721062", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721005" ], "products": [ "species_10720472", "species_10721035", "species_29420" ], "modifiers": [ [ "species_10721059", "catalyst" ] ], "additional_components": [ "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q55FM7", "DDB_G0268034", "species_29420", "Q54VT9", "DDB_G0280143", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q54CV2", "DDB_G0292682", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q557G3", "DDB_G0273467", "Q54U24", "DDB_G0281351", "Q54RV6", "DDB_G0282887", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135" ] }, "reaction_10720645": { "compartment": "compartment_263163", "id": "reaction_10720645", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720638", "species_29438" ], "products": [ "species_10720642", "species_10720472", "species_29420" ], "modifiers": [ [ "species_10716880", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q55FK2", "DDB_G0268068", "Q55FM7", "DDB_G0268034", "Q55FK2", "DDB_G0268068", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10720634": { "compartment": "compartment_263163", "id": "reaction_10720634", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720551" ], "products": [ "species_10720472", "species_10720603", "species_29420" ], "modifiers": [ [ "species_10720631", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "species_29420", "P36411", "DDB_G0269236", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q55DD7", "DDB_G0270918", "Q54JA6", "DDB_G0288237" ] }, "reaction_10720942": { "compartment": "compartment_171062", "id": "reaction_10720942", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720880" ], "products": [ "species_10720472", "species_10720884", "species_29420" ], "modifiers": [ [ "species_10720939", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MYF2", "DDB_G0277441", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q8MYF2", "DDB_G0277441", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115" ] }, "reaction_10721156": { "compartment": "compartment_12045", "id": "reaction_10721156", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721143" ], "products": [ "species_10720472", "species_29420", "species_10721147" ], "modifiers": [ [ "species_10721153", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q54GY8", "DDB_G0289827", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10722918": { "compartment": "compartment_5460", "id": "reaction_10722918", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722910" ], "products": [], "modifiers": [ [ "species_10722915", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "Q55BQ4", "DDB_G0270806", "Q55CS9", "DDB_G0269916", "Q54U71", "DDB_G0281241", "Q37315", "DDB_G0294016", "DDB_G0271506" ] }, "reaction_10679142": { "compartment": "compartment_7660", "id": "reaction_10679142", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679123", "species_10679128", "species_10679133", "species_10679138" ], "products": [ "species_10679140" ], "modifiers": [], "additional_components": [ "DDB_G0289271", "DDB_G0293564", "DDB_G0291506", "DDB_G0269324", "Q55EA2", "DDB_G0269324", "Q54BL9", "DDB_G0293564", "Q54HR6", "DDB_G0289271", "Q54EH6", "DDB_G0291506" ] }, "reaction_10670519": { "compartment": "compartment_7660", "id": "reaction_10670519", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669631" ], "products": [ "species_10669627", "species_10669598", "species_10669622", "species_10669615" ], "modifiers": [], "additional_components": [ "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "DDB_G0292958", "DDB_G0286623", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10726207": { "compartment": "compartment_7660", "id": "reaction_10726207", "reactome": "R-DDI-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669598", "species_10669615" ], "products": [ "species_10669617" ], "modifiers": [], "additional_components": [ "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669566": { "compartment": "compartment_7660", "id": "reaction_10669566", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10669561" ], "products": [ "species_10669563", "species_10669557" ], "modifiers": [ [ "species_10669561", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670517": { "compartment": "compartment_70101", "id": "reaction_10670517", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670400" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726203": { "compartment": "compartment_7660", "id": "reaction_10726203", "reactome": "R-DDI-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669627", "species_10669622" ], "products": [ "species_10669629" ], "modifiers": [], "additional_components": [ "DDB_G0292958", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309" ] }, "reaction_10669568": { "compartment": "compartment_7660", "id": "reaction_10669568", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669559", "species_10669535" ], "products": [ "species_10669561" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10669647": { "compartment": "compartment_7660", "id": "reaction_10669647", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669573", "species_10669643" ], "products": [ "species_10669645" ], "modifiers": [], "additional_components": [ "DDB_G0267748", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q55GA4", "DDB_G0267748", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933" ] }, "reaction_10670368": { "compartment": "compartment_7660", "id": "reaction_10670368", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10669557" ], "products": [ "species_10669559" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670392": { "compartment": "compartment_7660", "id": "reaction_10670392", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669499" ], "products": [ "species_113582", "species_10670371" ], "modifiers": [ [ "species_10670389", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726144": { "compartment": "compartment_7660", "id": "reaction_10726144", "reactome": "R-DDI-9749215", "name": "MCM8 binds CDC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669506", "species_10669499" ], "products": [ "species_10669508" ], "modifiers": [], "additional_components": [ "DDB_G0283009", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10669949": { "compartment": "compartment_7660", "id": "reaction_10669949", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669659", "species_10669917" ], "products": [ "species_10669920" ], "modifiers": [ [ "species_10669946", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0283073", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629" ] }, "reaction_10669510": { "compartment": "compartment_7660", "id": "reaction_10669510", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC(1-6) at replication origins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669499", "species_10669492" ], "products": [ "species_10669501" ], "modifiers": [ [ "species_10669508", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q552L8", "DDB_G0275983", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10670515": { "compartment": "compartment_70101", "id": "reaction_10670515", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10670394", "species_113592" ], "products": [ "species_10670400" ], "modifiers": [ [ "species_10670512", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275983", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10670359": { "compartment": "compartment_70101", "id": "reaction_10670359", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669951" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726205": { "compartment": "compartment_7660", "id": "reaction_10726205", "reactome": "R-DDI-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669603", "species_10669613", "species_10669608" ], "products": [ "species_10669615" ], "modifiers": [], "additional_components": [ "DDB_G0275623", "DDB_G0282933", "DDB_G0272760", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669953": { "compartment": "compartment_7660", "id": "reaction_10669953", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669920" ], "products": [ "species_10669951" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10670364": { "compartment": "compartment_7660", "id": "reaction_10670364", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10669563", "species_29604", "species_29892" ], "products": [ "species_10670361" ], "modifiers": [ [ "species_10669535", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10726146": { "compartment": "compartment_7660", "id": "reaction_10726146", "reactome": "R-DDI-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669617", "species_10669629" ], "products": [ "species_10669631" ], "modifiers": [], "additional_components": [ "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669687": { "compartment": "compartment_7660", "id": "reaction_10669687", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669653" ], "products": [ "species_113582", "species_10669659", "species_10669663" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q54RU0", "DDB_G0282933", "Q54RN8", "DDB_G0283009", "DDB_G0283073", "Q54CP4", "DDB_G0292958", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10670396": { "compartment": "compartment_7660", "id": "reaction_10670396", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670371" ], "products": [ "species_10670394" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10682559": { "compartment": "compartment_13231", "id": "reaction_10682559", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682537" ], "products": [ "species_10682557" ], "modifiers": [], "additional_components": [ "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184", "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184" ] }, "reaction_10682346": { "compartment": "compartment_7660", "id": "reaction_10682346", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340", "species_29428" ], "products": [ "species_10682344" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10682565": { "compartment": "compartment_70101", "id": "reaction_10682565", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682561" ], "products": [ "species_10682563" ], "modifiers": [ [ "species_10682513", "catalyst" ] ], "additional_components": [ "DDB_G0277849", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10697851": { "compartment": "compartment_70101", "id": "reaction_10697851", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697839", "species_29356" ], "products": [ "species_10697849", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066" ] }, "reaction_10697883": { "compartment": "compartment_70101", "id": "reaction_10697883", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697849" ], "products": [ "species_29370", "species_10697839" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10702356": { "compartment": "compartment_876", "id": "reaction_10702356", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10702353", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10726153": { "compartment": "compartment_5460", "id": "reaction_10726153", "reactome": "R-DDI-9749971", "name": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_9750012", "species_113593" ], "products": [ "species_159448", "species_9749985", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10726183": { "compartment": "compartment_70101", "id": "reaction_10726183", "reactome": "R-DDI-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10726180", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54C73", "DDB_G0293122" ] }, "reaction_10726191": { "compartment": "compartment_70101", "id": "reaction_10726191", "reactome": "R-DDI-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10726188", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726193": { "compartment": "compartment_12045", "id": "reaction_10726193", "reactome": "R-DDI-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726151": { "compartment": "compartment_17957", "id": "reaction_10726151", "reactome": "R-DDI-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726156": { "compartment": "compartment_17957", "id": "reaction_10726156", "reactome": "R-DDI-9749977", "name": "UGT1A6 glucuronates ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_174384" ], "products": [ "species_158602", "species_9749997" ], "modifiers": [ [ "species_10677028", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726178": { "compartment": "compartment_70101", "id": "reaction_10726178", "reactome": "R-DDI-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10726175", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "Q86HQ2", "DDB_G0274117", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q54JR2", "DDB_G0287691", "Q8T686", "DDB_G0289655" ] }, "reaction_10726168": { "compartment": "compartment_70101", "id": "reaction_10726168", "reactome": "R-DDI-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10726165", "catalyst" ] ], "additional_components": [ "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726158": { "compartment": "compartment_17957", "id": "reaction_10726158", "reactome": "R-DDI-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726160": { "compartment": "compartment_17957", "id": "reaction_10726160", "reactome": "R-DDI-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726149": { "compartment": "compartment_17957", "id": "reaction_10726149", "reactome": "R-DDI-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10709871", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726197": { "compartment": "compartment_70101", "id": "reaction_10726197", "reactome": "R-DDI-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10696232": { "compartment": "compartment_70101", "id": "reaction_10696232", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10671976", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10677043": { "compartment": "compartment_70101", "id": "reaction_10677043", "reactome": "R-DDI-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10677040", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726186": { "compartment": "compartment_70101", "id": "reaction_10726186", "reactome": "R-DDI-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "DDB_G0285165" ] }, "reaction_10696229": { "compartment": "compartment_70101", "id": "reaction_10696229", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10726195": { "compartment": "compartment_70101", "id": "reaction_10726195", "reactome": "R-DDI-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10673891": { "compartment": "compartment_7660", "id": "reaction_10673891", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673887", "species_10673882" ], "products": [ "species_10673889" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q54HB0", "DDB_G0289587", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339" ] }, "reaction_10674680": { "compartment": "compartment_350", "id": "reaction_10674680", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10673976", "catalyst" ], [ "species_10674678", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54RQ4", "DDB_G0282987", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10673978": { "compartment": "compartment_7660", "id": "reaction_10673978", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673972" ], "products": [ "species_10673887", "species_10673976" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q54HB0", "DDB_G0289587", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "DDB_G0289587", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339" ] }, "reaction_10683664": { "compartment": "compartment_70101", "id": "reaction_10683664", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683658" ], "products": [ "species_10683660", "species_10683662" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705971": { "compartment": "compartment_70101", "id": "reaction_10705971", "reactome": "R-DDI-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705850" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10705961": { "compartment": "compartment_70101", "id": "reaction_10705961", "reactome": "R-DDI-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705931" ], "products": [ "species_10705959" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10709756": { "compartment": "compartment_7660", "id": "reaction_10709756", "reactome": "R-DDI-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705955", "species_10670747" ], "products": [ "species_10709754" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10705903": { "compartment": "compartment_70101", "id": "reaction_10705903", "reactome": "R-DDI-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705864", "species_113592" ], "products": [ "species_29370", "species_10705900" ], "modifiers": [ [ "species_10702686", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705968": { "compartment": "compartment_7660", "id": "reaction_10705968", "reactome": "R-DDI-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705959" ], "products": [ "species_10705931" ], "modifiers": [ [ "species_10705966", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "DDB_G0291306" ] }, "reaction_10685265": { "compartment": "compartment_876", "id": "reaction_10685265", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685262", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685272": { "compartment": "compartment_876", "id": "reaction_10685272", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685269", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685247": { "compartment": "compartment_876", "id": "reaction_10685247", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685249": { "compartment": "compartment_876", "id": "reaction_10685249", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10674798": { "compartment": "compartment_7660", "id": "reaction_10674798", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10724052": { "compartment": "compartment_70101", "id": "reaction_10724052", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674686" ], "products": [ "species_10674690" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10705346": { "compartment": "compartment_7660", "id": "reaction_10705346", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705342" ], "products": [ "species_10705344" ], "modifiers": [], "additional_components": [ "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10705349": { "compartment": "compartment_7660", "id": "reaction_10705349", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705344" ], "products": [ "species_113582", "species_10670822" ], "modifiers": [ [ "species_10705344", "catalyst" ] ], "additional_components": [ "Q54MH0", "DDB_G0285963", "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10674688": { "compartment": "compartment_7660", "id": "reaction_10674688", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10702591": { "compartment": "compartment_876", "id": "reaction_10702591", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10702588" ], "products": [ "species_29370", "species_10702566" ], "modifiers": [ [ "species_10683660", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10698157": { "compartment": "compartment_70101", "id": "reaction_10698157", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10676232", "species_10695461" ], "products": [ "species_10698131" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034" ] }, "reaction_10698155": { "compartment": "compartment_70101", "id": "reaction_10698155", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698135" ], "products": [ "species_10698153" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10702593": { "compartment": "compartment_876", "id": "reaction_10702593", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10678454" ], "products": [ "species_10702588" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996" ] }, "reaction_10702481": { "compartment": "compartment_70101", "id": "reaction_10702481", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10702478" ], "products": [ "species_10683047", "species_76183" ], "modifiers": [ [ "species_10701954", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "DDB_G0279267" ] }, "reaction_10706065": { "compartment": "compartment_17927", "id": "reaction_10706065", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10706055" ], "products": [ "species_5688340", "species_5688281", "species_10676517" ], "modifiers": [ [ "species_10706062", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10722767": { "compartment": "compartment_876", "id": "reaction_10722767", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722762" ], "products": [ "species_10722748", "species_29372" ], "modifiers": [ [ "species_10722762", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10676269": { "compartment": "compartment_70101", "id": "reaction_10676269", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10678297": { "compartment": "compartment_876", "id": "reaction_10678297", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678304": { "compartment": "compartment_876", "id": "reaction_10678304", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678285" ], "products": [ "species_29372", "species_10678299" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10722750": { "compartment": "compartment_876", "id": "reaction_10722750", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722748" ], "products": [ "species_10678290", "species_10722746" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10682978": { "compartment": "compartment_947587", "id": "reaction_10682978", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682971" ], "products": [ "species_29420", "species_10682975" ], "modifiers": [ [ "species_10682971", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_29438", "P36408", "DDB_G0277143", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349" ] }, "reaction_10678288": { "compartment": "compartment_876", "id": "reaction_10678288", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10678254" ], "products": [ "species_10678285" ], "modifiers": [ [ "species_10676221", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10678301": { "compartment": "compartment_876", "id": "reaction_10678301", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678299" ], "products": [ "species_10676221", "species_10678276" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10677642": { "compartment": "compartment_947587", "id": "reaction_10677642", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_29420" ], "products": [ "species_29438", "species_10676271" ], "modifiers": [ [ "species_10676139", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10722764": { "compartment": "compartment_876", "id": "reaction_10722764", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678270", "species_10722746" ], "products": [ "species_10722762" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10724973": { "compartment": "compartment_70101", "id": "reaction_10724973", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10679149", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10697954": { "compartment": "compartment_876", "id": "reaction_10697954", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10697951", "catalyst" ] ], "additional_components": [ "Q86I16", "DDB_G0275169", "Q54SN1", "DDB_G0282291", "Q55CU6", "DDB_G0275169" ] }, "reaction_10676383": { "compartment": "compartment_7660", "id": "reaction_10676383", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10676338", "species_10672161" ], "products": [ "species_10673970", "species_10676376" ], "modifiers": [ [ "species_10676338", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "DDB_G0271690", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0271690" ] }, "reaction_10676458": { "compartment": "compartment_7660", "id": "reaction_10676458", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676454" ], "products": [ "species_10676456" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676444": { "compartment": "compartment_7660", "id": "reaction_10676444", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676440" ], "products": [ "species_10673970", "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K42", "DDB_G0287661", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676466": { "compartment": "compartment_7660", "id": "reaction_10676466", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676376", "species_10676333" ], "products": [ "species_10676378" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676472": { "compartment": "compartment_7660", "id": "reaction_10676472", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676442" ], "products": [ "species_9757634", "species_10676454" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10697522": { "compartment": "compartment_70101", "id": "reaction_10697522", "reactome": "R-DDI-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473617", "species_10674488" ], "products": [ "species_10697520" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_5623649", "Q54YX3", "DDB_G0278031" ] }, "reaction_10697518": { "compartment": "compartment_70101", "id": "reaction_10697518", "reactome": "R-DDI-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674490", "species_200993" ], "products": [ "species_76194", "species_10697513" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "species_30927", "Q54YX3", "DDB_G0278031", "CHEBI:16254", "Q54YX3", "DDB_G0278031", "DDB_G0290279" ] }, "reaction_10676906": { "compartment": "compartment_7660", "id": "reaction_10676906", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676900" ], "products": [ "species_29370", "species_10676904" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10697578": { "compartment": "compartment_1598585", "id": "reaction_10697578", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697563" ], "products": [ "species_29370", "species_10697575" ], "modifiers": [ [ "species_10678756", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0274503" ] }, "reaction_10675117": { "compartment": "compartment_7660", "id": "reaction_10675117", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675051" ], "products": [ "species_10675115" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10725407": { "compartment": "compartment_876", "id": "reaction_10725407", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10704197" ], "products": [ "species_10704199" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10704211": { "compartment": "compartment_876", "id": "reaction_10704211", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704197" ], "products": [ "species_29370", "species_10704188" ], "modifiers": [ [ "species_10704197", "catalyst" ], [ "species_10704209", "inhibitor" ], [ "species_10704199", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10725409": { "compartment": "compartment_876", "id": "reaction_10725409", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657570" ], "products": [ "species_10704201" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385" ] }, "reaction_10725415": { "compartment": "compartment_876", "id": "reaction_10725415", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10704192" ], "products": [ "species_10725413" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9229", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P18160", "DDB_G0283385" ] }, "reaction_10725411": { "compartment": "compartment_876", "id": "reaction_10725411", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657574" ], "products": [ "species_10704195" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704203": { "compartment": "compartment_876", "id": "reaction_10704203", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704188" ], "products": [ "species_29370", "species_10704192" ], "modifiers": [ [ "species_10704188", "catalyst" ], [ "species_10704199", "inhibitor" ], [ "species_10704201", "inhibitor" ], [ "species_10704195", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704251": { "compartment": "compartment_74700", "id": "reaction_10704251", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704247" ], "products": [ "species_29370", "species_10704249" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833" ] }, "reaction_10700856": { "compartment": "compartment_7660", "id": "reaction_10700856", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_113671", "species_113685" ], "products": [ "species_10698653", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10699170": { "compartment": "compartment_7660", "id": "reaction_10699170", "reactome": "R-DDI-3318486", "name": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_113560" ], "products": [ "species_2485002", "species_10699149" ], "modifiers": [ [ "species_10699167", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10701877": { "compartment": "compartment_7660", "id": "reaction_10701877", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_77087" ], "products": [ "species_10696628", "species_77502" ], "modifiers": [ [ "species_10701874", "catalyst" ], [ "species_10701399", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q54MH6", "DDB_G0285847", "Q54IV4", "DDB_G0288495", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "O15819", "DDB_G0267402" ] }, "reaction_10703003": { "compartment": "compartment_7660", "id": "reaction_10703003", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702990", "species_77087" ], "products": [ "species_10702995", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10701096": { "compartment": "compartment_7660", "id": "reaction_10701096", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698653", "species_77502" ], "modifiers": [ [ "species_10701093", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q86A13", "DDB_G0287857", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132", "Q54J80", "DDB_G0288227" ] }, "reaction_10703010": { "compartment": "compartment_7660", "id": "reaction_10703010", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702995", "species_77087" ], "products": [ "species_10703008", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700971": { "compartment": "compartment_7660", "id": "reaction_10700971", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700828", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10701276": { "compartment": "compartment_7660", "id": "reaction_10701276", "reactome": "R-DDI-5205799", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698791", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ], [ "species_10701274", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "Q54NM0", "DDB_G0285205", "Q54WV6", "DDB_G0279373", "Q556Z0", "DDB_G0273203", "Q55C32", "DDB_G0285205", "Q54UQ7", "DDB_G0280887", "Q54KI3", "DDB_G0287327", "Q550R6", "DDB_G0277033" ] }, "reaction_10703386": { "compartment": "compartment_7660", "id": "reaction_10703386", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701268", "species_77087" ], "products": [ "species_10703384", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703018": { "compartment": "compartment_7660", "id": "reaction_10703018", "reactome": "R-DDI-5649802", "name": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10700861" ], "products": [ "species_77502", "species_10703016" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703368": { "compartment": "compartment_7660", "id": "reaction_10703368", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696628", "species_113685" ], "products": [ "species_159942", "species_10696623", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10702952": { "compartment": "compartment_7660", "id": "reaction_10702952", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700828", "species_77087" ], "products": [ "species_10702945", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10698670": { "compartment": "compartment_7660", "id": "reaction_10698670", "reactome": "R-DDI-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653" ], "products": [ "species_10698655", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10699592": { "compartment": "compartment_7660", "id": "reaction_10699592", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_113560" ], "products": [ "species_2485002", "species_10699570" ], "modifiers": [ [ "species_10699589", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q86J12", "DDB_G0274269", "Q54QW6", "DDB_G0283565" ] }, "reaction_10725840": { "compartment": "compartment_7660", "id": "reaction_10725840", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699922", "species_9679795" ], "products": [ "species_10699925" ], "modifiers": [], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "LigandDisplayForward?ligandId=7489", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10701685": { "compartment": "compartment_7660", "id": "reaction_10701685", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701663", "species_10701077" ], "products": [ "species_10701683" ], "modifiers": [], "additional_components": [ "O15819", "DDB_G0267402", "DDB_G0287273", "Q54KL5", "DDB_G0287273", "O15819", "DDB_G0267402" ] }, "reaction_10701512": { "compartment": "compartment_7660", "id": "reaction_10701512", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10701458" ], "products": [ "species_10701510", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "DDB_G0291556" ] }, "reaction_10701271": { "compartment": "compartment_7660", "id": "reaction_10701271", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_77087" ], "products": [ "species_10701268", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703381": { "compartment": "compartment_7660", "id": "reaction_10703381", "reactome": "R-DDI-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623" ], "products": [ "species_10698653", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10702931": { "compartment": "compartment_7660", "id": "reaction_10702931", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653", "species_77087" ], "products": [ "species_10696623", "species_77502" ], "modifiers": [ [ "species_10702928", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54IV4", "DDB_G0288495", "Q86A13", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703014": { "compartment": "compartment_7660", "id": "reaction_10703014", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10702990", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700840": { "compartment": "compartment_7660", "id": "reaction_10700840", "reactome": "R-DDI-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_113671", "species_113685" ], "products": [ "species_10700832", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10701689": { "compartment": "compartment_7660", "id": "reaction_10701689", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_10699587" ], "products": [ "species_10701687" ], "modifiers": [ [ "species_10701663", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "O15819", "DDB_G0267402", "Q54QW6", "DDB_G0283565", "O15819", "DDB_G0267402" ] }, "reaction_10703379": { "compartment": "compartment_7660", "id": "reaction_10703379", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10703016", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10700861" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10700873": { "compartment": "compartment_7660", "id": "reaction_10700873", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10700861", "species_113685" ], "products": [ "species_10700866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10699111": { "compartment": "compartment_7660", "id": "reaction_10699111", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696626", "species_113560" ], "products": [ "species_2485002", "species_10699070" ], "modifiers": [ [ "species_10699108", "catalyst" ] ], "additional_components": [ "DDB_G0267402", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10698695": { "compartment": "compartment_7660", "id": "reaction_10698695", "reactome": "R-DDI-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698686" ], "products": [ "species_10698692" ], "modifiers": [ [ "species_10698686", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10700892": { "compartment": "compartment_7660", "id": "reaction_10700892", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_77087" ], "products": [ "species_77502", "species_10700884" ], "modifiers": [ [ "species_10700889", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0289257" ] }, "reaction_10703012": { "compartment": "compartment_7660", "id": "reaction_10703012", "reactome": "R-DDI-5649800", "name": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700866", "species_77087" ], "products": [ "species_77502", "species_10700861" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703377": { "compartment": "compartment_7660", "id": "reaction_10703377", "reactome": "R-DDI-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10700884" ], "products": [ "species_10700830", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10703375": { "compartment": "compartment_7660", "id": "reaction_10703375", "reactome": "R-DDI-5661117", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698791", "species_77087" ], "products": [ "species_10703373", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10699927": { "compartment": "compartment_7660", "id": "reaction_10699927", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699922", "catalyst" ], [ "species_10699925", "inhibitor" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10702957": { "compartment": "compartment_7660", "id": "reaction_10702957", "reactome": "R-DDI-5638333", "name": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700866", "species_77502" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10699946": { "compartment": "compartment_7660", "id": "reaction_10699946", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699943", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10682182": { "compartment": "compartment_984", "id": "reaction_10682182", "reactome": "R-DDI-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10682179", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10682338": { "compartment": "compartment_876", "id": "reaction_10682338", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216762", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171095", "species_29372" ], "modifiers": [ [ "species_10682335", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10701034": { "compartment": "compartment_7660", "id": "reaction_10701034", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_29358" ], "products": [ "species_113582", "species_10701011" ], "modifiers": [ [ "species_10701031", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569" ] }, "reaction_10701013": { "compartment": "compartment_7660", "id": "reaction_10701013", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700995" ], "products": [ "species_10701001" ], "modifiers": [ [ "species_10701006", "catalyst" ], [ "species_10701011", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10684049": { "compartment": "compartment_70101", "id": "reaction_10684049", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10682591" ], "products": [ "species_10684047" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10687177": { "compartment": "compartment_70101", "id": "reaction_10687177", "reactome": "R-DDI-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10683990" ], "products": [ "species_10683995" ], "modifiers": [ [ "species_10687175", "inhibitor" ] ], "additional_components": [ "DDB_G0269138", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10684035": { "compartment": "compartment_70101", "id": "reaction_10684035", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10684031" ], "products": [ "species_10684033" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683997": { "compartment": "compartment_70101", "id": "reaction_10683997", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682591" ], "products": [ "species_10682593", "species_111294" ], "modifiers": [ [ "species_10683992", "catalyst" ], [ "species_10683995", "inhibitor" ] ], "additional_components": [ "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10675956": { "compartment": "compartment_7660", "id": "reaction_10675956", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675951" ], "products": [ "species_10675953", "species_110242" ], "modifiers": [ [ "species_10675951", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675977": { "compartment": "compartment_7660", "id": "reaction_10675977", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675972" ], "products": [ "species_10675974", "species_5635947" ], "modifiers": [ [ "species_10675972", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10711308": { "compartment": "compartment_984", "id": "reaction_10711308", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10711305", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10685610": { "compartment": "compartment_70101", "id": "reaction_10685610", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683631", "species_113592", "species_10676526" ], "products": [ "species_29370", "species_10683629", "species_10685607" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10687031": { "compartment": "compartment_876", "id": "reaction_10687031", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687023", "species_10687027" ], "products": [ "species_10687029" ], "modifiers": [], "additional_components": [ "DDB_G0287833", "species_1236719", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125", "species_1236719", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125" ] }, "reaction_10716012": { "compartment": "compartment_7660", "id": "reaction_10716012", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10716000" ], "products": [ "species_113582", "species_10716009" ], "modifiers": [ [ "species_10716000", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54FD6", "DDB_G0290929", "Q54KJ8", "DDB_G0287307", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131" ] }, "reaction_10676885": { "compartment": "compartment_7660", "id": "reaction_10676885", "reactome": "R-DDI-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676872" ], "products": [ "species_113582", "species_10676876" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10676923": { "compartment": "compartment_7660", "id": "reaction_10676923", "reactome": "R-DDI-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676918" ], "products": [ "species_113582", "species_10676921" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10726046": { "compartment": "compartment_70101", "id": "reaction_10726046", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721285", "species_9714134" ], "products": [ "species_10726044" ], "modifiers": [], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "Q54NZ5", "DDB_G0284903", "LigandDisplayForward?ligandId=6569", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10682925": { "compartment": "compartment_70101", "id": "reaction_10682925", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_9677992" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10682923": { "compartment": "compartment_70101", "id": "reaction_10682923", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362", "species_29368", "species_29356" ], "products": [ "species_29408", "species_9677997", "species_29382" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683515": { "compartment": "compartment_17947", "id": "reaction_10683515", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683513", "species_10683495" ], "products": [ "species_10683511", "species_10683487", "species_10683495" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213" ] }, "reaction_10691278": { "compartment": "compartment_70101", "id": "reaction_10691278", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10691275", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10704829": { "compartment": "compartment_984", "id": "reaction_10704829", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429802", "species_29356" ], "products": [ "species_29370", "species_382539", "species_29372" ], "modifiers": [ [ "species_10704826", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10691271": { "compartment": "compartment_70101", "id": "reaction_10691271", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10691268", "catalyst" ] ], "additional_components": [ "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10716905": { "compartment": "compartment_70101", "id": "reaction_10716905", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_113592", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10716902", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10705130": { "compartment": "compartment_70101", "id": "reaction_10705130", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10705127", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10682286": { "compartment": "compartment_876", "id": "reaction_10682286", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265784", "species_113592", "species_29356" ], "products": [ "species_29370", "species_265781", "species_29372" ], "modifiers": [ [ "species_10682283", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q55DW4", "DDB_G0269214" ] }, "reaction_10691341": { "compartment": "compartment_876", "id": "reaction_10691341", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131652", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1467459" ], "modifiers": [ [ "species_10691338", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54BU4", "DDB_G0293416", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T9W4", "DDB_G0291714", "Q8T9W1", "DDB_G0286123", "Q54RU1", "DDB_G0282931", "Q8T6J5", "DDB_G0267438", "Q54W24", "DDB_G0279915", "Q54R52", "DDB_G0283387", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438" ] }, "reaction_10683474": { "compartment": "compartment_70616", "id": "reaction_10683474", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10683471", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W2", "DDB_G0292554", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10701720": { "compartment": "compartment_70101", "id": "reaction_10701720", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10701716" ], "products": [ "species_10701718" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436", "Q869N9", "DDB_G0271862" ] }, "reaction_10690498": { "compartment": "compartment_876", "id": "reaction_10690498", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10690500": { "compartment": "compartment_876", "id": "reaction_10690500", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_171149", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10691362": { "compartment": "compartment_74000", "id": "reaction_10691362", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_2466098" ], "products": [ "species_29370", "species_975622", "species_29372" ], "modifiers": [ [ "species_10691359", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10683490": { "compartment": "compartment_17947", "id": "reaction_10683490", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10683487", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10677433": { "compartment": "compartment_70101", "id": "reaction_10677433", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10677430" ], "modifiers": [ [ "species_10675814", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10722655": { "compartment": "compartment_876", "id": "reaction_10722655", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722652" ], "products": [ "species_10679174", "species_10679153" ], "modifiers": [ [ "species_10722652", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10722657": { "compartment": "compartment_876", "id": "reaction_10722657", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679174", "species_10678454" ], "products": [ "species_10722652" ], "modifiers": [], "additional_components": [ "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10716950": { "compartment": "compartment_876", "id": "reaction_10716950", "reactome": "R-DDI-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10716947", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q55GR7", "DDB_G0267548", "Q54WH5", "DDB_G0279657", "Q54RS7", "DDB_G0282949", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54YW1", "DDB_G0278051", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54NW4", "DDB_G0284863" ] }, "reaction_10716247": { "compartment": "compartment_263163", "id": "reaction_10716247", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716238" ], "products": [ "species_10716244", "species_29420" ], "modifiers": [ [ "species_10716238", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716664": { "compartment": "compartment_263163", "id": "reaction_10716664", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716608", "species_10710119", "species_10710110" ], "products": [ "species_10716662" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716705": { "compartment": "compartment_263163", "id": "reaction_10716705", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716701", "species_10710119", "species_10710110" ], "products": [ "species_10716703" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716764": { "compartment": "compartment_263163", "id": "reaction_10716764", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716751", "species_10716762" ], "products": [ "species_10716753" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0278181", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716760": { "compartment": "compartment_263163", "id": "reaction_10716760", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716753" ], "products": [ "species_10716757" ], "modifiers": [ [ "species_10716753", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716424": { "compartment": "compartment_263163", "id": "reaction_10716424", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716420", "species_10716405" ], "products": [ "species_10716422" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716667": { "compartment": "compartment_263163", "id": "reaction_10716667", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716662", "species_113592" ], "products": [ "species_29370", "species_10716530", "species_10716540", "species_10710119", "species_10716596", "species_10710110", "species_10716532" ], "modifiers": [ [ "species_10716662", "catalyst" ] ], "additional_components": [ "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575", "DDB_G0284185", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0290363", "Q75JI3", "DDB_G0276153", "DDB_G0276575", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716407": { "compartment": "compartment_263163", "id": "reaction_10716407", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716399", "species_10716391" ], "products": [ "species_10716405" ], "modifiers": [], "additional_components": [ "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716240": { "compartment": "compartment_263163", "id": "reaction_10716240", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716220", "species_10716232" ], "products": [ "species_10716238" ], "modifiers": [], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716413": { "compartment": "compartment_263163", "id": "reaction_10716413", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716411", "species_10716381" ], "products": [ "species_10716391" ], "modifiers": [], "additional_components": [ "species_29438", "Q54QU7", "DDB_G0283631", "DDB_G0269368", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10721886": { "compartment": "compartment_70616", "id": "reaction_10721886", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10721883", "catalyst" ] ], "additional_components": [ "Q54LT0", "DDB_G0286429", "Q54JS1", "DDB_G0287825" ] }, "reaction_10685511": { "compartment": "compartment_876", "id": "reaction_10685511", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10685508", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10697358": { "compartment": "compartment_984", "id": "reaction_10697358", "reactome": "R-DDI-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697305" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696943": { "compartment": "compartment_984", "id": "reaction_10696943", "reactome": "R-DDI-2213210", "name": "Collagen IX is cross-linked to the surface of collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696939", "species_10691415" ], "products": [ "species_10696941" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10698054": { "compartment": "compartment_984", "id": "reaction_10698054", "reactome": "R-DDI-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_351629" ], "products": [ "species_10698047" ], "modifiers": [ [ "species_10698051", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q6TMK4", "DDB_G0277275", "CHEBI:15858" ] }, "reaction_10697211": { "compartment": "compartment_984", "id": "reaction_10697211", "reactome": "R-DDI-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697099" ], "products": [ "species_10697209" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696855": { "compartment": "compartment_984", "id": "reaction_10696855", "reactome": "R-DDI-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696849" ], "products": [ "species_10696853" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697334": { "compartment": "compartment_984", "id": "reaction_10697334", "reactome": "R-DDI-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10694584" ], "products": [ "species_10697099" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697103": { "compartment": "compartment_984", "id": "reaction_10697103", "reactome": "R-DDI-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10697099" ], "products": [ "species_10697101" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696859": { "compartment": "compartment_984", "id": "reaction_10696859", "reactome": "R-DDI-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696851", "species_10691415" ], "products": [ "species_10696857" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697360": { "compartment": "compartment_984", "id": "reaction_10697360", "reactome": "R-DDI-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697183" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697250": { "compartment": "compartment_984", "id": "reaction_10697250", "reactome": "R-DDI-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691593", "species_10691415" ], "products": [ "species_10697248" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697332": { "compartment": "compartment_984", "id": "reaction_10697332", "reactome": "R-DDI-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305" ], "products": [ "species_10697330" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697414": { "compartment": "compartment_984", "id": "reaction_10697414", "reactome": "R-DDI-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305", "species_10697099" ], "products": [ "species_10697412" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697166": { "compartment": "compartment_984", "id": "reaction_10697166", "reactome": "R-DDI-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694584", "species_10676611" ], "products": [ "species_10697164" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697387": { "compartment": "compartment_984", "id": "reaction_10697387", "reactome": "R-DDI-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697305" ], "products": [ "species_10697385" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696823": { "compartment": "compartment_984", "id": "reaction_10696823", "reactome": "R-DDI-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691599" ], "products": [ "species_10696821" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10691601": { "compartment": "compartment_984", "id": "reaction_10691601", "reactome": "R-DDI-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691589" ], "products": [ "species_10691599" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10676916": { "compartment": "compartment_7660", "id": "reaction_10676916", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670658" ], "products": [ "species_113582", "species_10676914" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0274503" ] }, "reaction_10676895": { "compartment": "compartment_7660", "id": "reaction_10676895", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676887" ], "products": [ "species_29370", "species_10676890" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10677114": { "compartment": "compartment_7660", "id": "reaction_10677114", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10677109" ], "products": [ "species_113582", "species_10677112" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0291842", "DDB_G0291842", "DDB_G0274503" ] }, "reaction_10697270": { "compartment": "compartment_984", "id": "reaction_10697270", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697266", "species_10695841" ], "products": [ "species_10697268" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485" ] }, "reaction_10695849": { "compartment": "compartment_984", "id": "reaction_10695849", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695819" ], "products": [ "species_10695847" ], "modifiers": [], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485" ] }, "reaction_10724643": { "compartment": "compartment_70101", "id": "reaction_10724643", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724639", "species_10676232" ], "products": [ "species_10724641" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10724634": { "compartment": "compartment_70101", "id": "reaction_10724634", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724627", "species_113592" ], "products": [ "species_29370", "species_10724631" ], "modifiers": [ [ "species_10724627", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10726201": { "compartment": "compartment_7660", "id": "reaction_10726201", "reactome": "R-DDI-9754130", "name": "CDK4 inhibitors bind CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9754127", "species_10670762" ], "products": [ "species_10670773" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680" ] }, "reaction_10723600": { "compartment": "compartment_7660", "id": "reaction_10723600", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698648", "species_10670680" ], "products": [ "species_10723598" ], "modifiers": [ [ "species_10670387", "inhibitor" ], [ "species_10670764", "inhibitor" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10721692": { "compartment": "compartment_7660", "id": "reaction_10721692", "reactome": "R-DDI-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10721688" ], "products": [ "species_113582", "species_10670764" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10670637": { "compartment": "compartment_70101", "id": "reaction_10670637", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670633", "species_10670619" ], "products": [ "species_10670635" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690366": { "compartment": "compartment_7660", "id": "reaction_10690366", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690027" ], "products": [ "species_113550", "species_10690019" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678594": { "compartment": "compartment_70101", "id": "reaction_10678594", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678224", "species_10670619" ], "products": [ "species_10678592" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10676508": { "compartment": "compartment_7660", "id": "reaction_10676508", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10676480", "species_113656" ], "products": [ "species_113550", "species_10676482" ], "modifiers": [ [ "species_10676505", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10670666": { "compartment": "compartment_7660", "id": "reaction_10670666", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_113582", "species_10670646" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10721690": { "compartment": "compartment_13231", "id": "reaction_10721690", "reactome": "R-DDI-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721670" ], "products": [ "species_10721688" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10678230": { "compartment": "compartment_13231", "id": "reaction_10678230", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678226" ], "products": [ "species_10678228" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10670783": { "compartment": "compartment_7660", "id": "reaction_10670783", "reactome": "R-DDI-69227", "name": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670680" ], "products": [ "species_113582", "species_10670683" ], "modifiers": [ [ "species_10670764", "catalyst" ], [ "species_10670773", "inhibitor" ], [ "species_10670781", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10698510": { "compartment": "compartment_70101", "id": "reaction_10698510", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676892" ], "products": [ "species_10676882" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10678242": { "compartment": "compartment_13231", "id": "reaction_10678242", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678238" ], "products": [ "species_10678240" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10679206": { "compartment": "compartment_7660", "id": "reaction_10679206", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679202", "species_10669684" ], "products": [ "species_10679204" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10717991": { "compartment": "compartment_70101", "id": "reaction_10717991", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717986" ], "products": [ "species_10670153", "species_10717891" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10718380": { "compartment": "compartment_7660", "id": "reaction_10718380", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718364" ], "products": [ "species_10690363", "species_8857797" ], "modifiers": [ [ "species_10718377", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0281651" ] }, "reaction_10696428": { "compartment": "compartment_7660", "id": "reaction_10696428", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696414", "species_29358" ], "products": [ "species_113582", "species_10696417" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10678234": { "compartment": "compartment_13231", "id": "reaction_10678234", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676890" ], "products": [ "species_10678232" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10697660": { "compartment": "compartment_7660", "id": "reaction_10697660", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697640", "species_113560" ], "products": [ "species_2485002", "species_10697648" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10690017": { "compartment": "compartment_7660", "id": "reaction_10690017", "reactome": "R-DDI-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_29358" ], "products": [ "species_113582", "species_10690015", "species_10690013" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726199": { "compartment": "compartment_7660", "id": "reaction_10726199", "reactome": "R-DDI-9754129", "name": "CDK6 inhibitors bind CDK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670751", "species_9754132" ], "products": [ "species_10670781" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10717895": { "compartment": "compartment_70101", "id": "reaction_10717895", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678761", "species_10717891" ], "products": [ "species_10717893" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10679247": { "compartment": "compartment_7660", "id": "reaction_10679247", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_10670387", "species_113582" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10677004": { "compartment": "compartment_13231", "id": "reaction_10677004", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670635" ], "products": [ "species_10670641" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10717989": { "compartment": "compartment_70101", "id": "reaction_10717989", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10717893" ], "products": [ "species_10717986" ], "modifiers": [ [ "species_10717893", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10690392": { "compartment": "compartment_7660", "id": "reaction_10690392", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679187", "species_10690013" ], "products": [ "species_10690390" ], "modifiers": [], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "DDB_G0290551", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10690031": { "compartment": "compartment_7660", "id": "reaction_10690031", "reactome": "R-DDI-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10690021" ], "products": [ "species_113582", "species_10690027", "species_10690029" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679253": { "compartment": "compartment_7660", "id": "reaction_10679253", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670387", "species_10670683" ], "products": [ "species_10679251" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679256": { "compartment": "compartment_7660", "id": "reaction_10679256", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679251" ], "products": [ "species_113582", "species_10670387", "species_10676480" ], "modifiers": [ [ "species_10679251", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10697703": { "compartment": "compartment_7660", "id": "reaction_10697703", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697699", "species_113560" ], "products": [ "species_2485002", "species_10697701" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10697598": { "compartment": "compartment_70101", "id": "reaction_10697598", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697587" ], "products": [ "species_10697595" ], "modifiers": [ [ "species_10697587", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10670675": { "compartment": "compartment_7660", "id": "reaction_10670675", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10670646" ], "products": [ "species_113550", "species_10670641" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10725467": { "compartment": "compartment_70101", "id": "reaction_10725467", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725465" ], "products": [ "species_10670680" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10679227": { "compartment": "compartment_7660", "id": "reaction_10679227", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679204", "species_29358" ], "products": [ "species_113582", "species_10679224" ], "modifiers": [ [ "species_10679204", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10678793": { "compartment": "compartment_7660", "id": "reaction_10678793", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678789", "species_113518" ], "products": [ "species_113550", "species_10678791" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10697034": { "compartment": "compartment_20699", "id": "reaction_10697034", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697026", "species_113592" ], "products": [ "species_29370", "species_10697031" ], "modifiers": [ [ "species_10697026", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248" ] }, "reaction_10697509": { "compartment": "compartment_7660", "id": "reaction_10697509", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697504", "species_29358" ], "products": [ "species_113582", "species_10697507" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10721628": { "compartment": "compartment_70101", "id": "reaction_10721628", "reactome": "R-DDI-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674818", "species_10721624" ], "products": [ "species_10721626" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10718372": { "compartment": "compartment_7660", "id": "reaction_10718372", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690363", "species_77087" ], "products": [ "species_10718364", "species_77502" ], "modifiers": [ [ "species_10718369", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0288271" ] }, "reaction_10690397": { "compartment": "compartment_7660", "id": "reaction_10690397", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690390", "species_10669917" ], "products": [ "species_10679187", "species_10690394" ], "modifiers": [ [ "species_10690390", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q54FX2", "DDB_G0290551", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10676510": { "compartment": "compartment_7660", "id": "reaction_10676510", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670361" ], "products": [ "species_10669535", "species_113656" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10679215": { "compartment": "compartment_7660", "id": "reaction_10679215", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10669684" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10679212": { "compartment": "compartment_7660", "id": "reaction_10679212", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679208" ], "products": [ "species_113582", "species_10679210" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679193": { "compartment": "compartment_7660", "id": "reaction_10679193", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679191" ], "products": [ "species_10679187", "species_10670389", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P34112", "DDB_G0272813", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "B0G102", "DDB_G0271642", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678870": { "compartment": "compartment_13231", "id": "reaction_10678870", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678592" ], "products": [ "species_10678791" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690368": { "compartment": "compartment_7660", "id": "reaction_10690368", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690013" ], "products": [ "species_113550", "species_10689991" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678849": { "compartment": "compartment_7660", "id": "reaction_10678849", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10678789" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10697448": { "compartment": "compartment_984", "id": "reaction_10697448", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697444", "species_10692323" ], "products": [ "species_10697446" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q54LD6", "DDB_G0286691", "Q55E77", "DDB_G0270488" ] }, "reaction_10721829": { "compartment": "compartment_17957", "id": "reaction_10721829", "reactome": "R-DDI-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692649" ], "products": [ "species_10692647", "species_10692513" ], "modifiers": [], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0280773" ] }, "reaction_10721764": { "compartment": "compartment_17957", "id": "reaction_10721764", "reactome": "R-DDI-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695220" ], "products": [ "species_10695222" ], "modifiers": [], "additional_components": [ "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721774": { "compartment": "compartment_17957", "id": "reaction_10721774", "reactome": "R-DDI-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694722", "species_10694792", "species_10694768", "species_10694746", "species_10694814", "species_10694700" ], "products": [ "species_10694818" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694524": { "compartment": "compartment_17957", "id": "reaction_10694524", "reactome": "R-DDI-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692579", "species_10692513" ], "products": [ "species_10692581" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "DDB_G0280773", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721748": { "compartment": "compartment_17957", "id": "reaction_10721748", "reactome": "R-DDI-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694886", "species_10694840", "species_10694862" ], "products": [ "species_10694892" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721766": { "compartment": "compartment_17957", "id": "reaction_10721766", "reactome": "R-DDI-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695286" ], "products": [ "species_10695288" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721776": { "compartment": "compartment_17957", "id": "reaction_10721776", "reactome": "R-DDI-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695072", "species_10694652", "species_10695050" ], "products": [ "species_10695074" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721742": { "compartment": "compartment_17957", "id": "reaction_10721742", "reactome": "R-DDI-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694914", "species_10694936" ], "products": [ "species_10694938" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721738": { "compartment": "compartment_17957", "id": "reaction_10721738", "reactome": "R-DDI-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694606", "species_10694628" ], "products": [ "species_10694630" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721772": { "compartment": "compartment_17957", "id": "reaction_10721772", "reactome": "R-DDI-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694652" ], "products": [ "species_10694654" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697502": { "compartment": "compartment_984", "id": "reaction_10697502", "reactome": "R-DDI-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_10697498" ], "products": [ "species_10697500" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10721768": { "compartment": "compartment_17957", "id": "reaction_10721768", "reactome": "R-DDI-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695096" ], "products": [ "species_10695098" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721750": { "compartment": "compartment_17957", "id": "reaction_10721750", "reactome": "R-DDI-8944225", "name": "Association of procollagen type XVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695168" ], "products": [ "species_10695170" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721752": { "compartment": "compartment_17957", "id": "reaction_10721752", "reactome": "R-DDI-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695240" ], "products": [ "species_10695242" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700154": { "compartment": "compartment_984", "id": "reaction_10700154", "reactome": "R-DDI-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700150", "species_10697474" ], "products": [ "species_10700152" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10693910": { "compartment": "compartment_17957", "id": "reaction_10693910", "reactome": "R-DDI-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693906" ], "products": [ "species_10693908" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721746": { "compartment": "compartment_17957", "id": "reaction_10721746", "reactome": "R-DDI-8944220", "name": "Association of procollagen type XXIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695262" ], "products": [ "species_10695264" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694522": { "compartment": "compartment_984", "id": "reaction_10694522", "reactome": "R-DDI-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694218" ], "products": [ "species_10694510" ], "modifiers": [ [ "species_10694515", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0279795" ] }, "reaction_10696111": { "compartment": "compartment_17957", "id": "reaction_10696111", "reactome": "R-DDI-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696025" ], "products": [ "species_10696109" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721762": { "compartment": "compartment_17957", "id": "reaction_10721762", "reactome": "R-DDI-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695310" ], "products": [ "species_10695312" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700148": { "compartment": "compartment_984", "id": "reaction_10700148", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700144", "species_10692323" ], "products": [ "species_10700146" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10721760": { "compartment": "compartment_17957", "id": "reaction_10721760", "reactome": "R-DDI-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694676" ], "products": [ "species_10694678" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721770": { "compartment": "compartment_17957", "id": "reaction_10721770", "reactome": "R-DDI-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695026" ], "products": [ "species_10695028" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721740": { "compartment": "compartment_17957", "id": "reaction_10721740", "reactome": "R-DDI-8944216", "name": "Association of procollagen type XV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695120" ], "products": [ "species_10695122" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10692690": { "compartment": "compartment_17957", "id": "reaction_10692690", "reactome": "R-DDI-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10692581" ], "products": [ "species_159751", "species_1650769", "species_10692649" ], "modifiers": [ [ "species_10692687", "catalyst" ] ], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "CHEBI:29073", "Q553P3", "DDB_G0292888", "Q54N51", "DDB_G0292888", "species_71067", "Q54TF2", "DDB_G0292888", "Q54CK1", "DDB_G0292888" ] }, "reaction_10721744": { "compartment": "compartment_17957", "id": "reaction_10721744", "reactome": "R-DDI-8944219", "name": "Association of procollagen type XVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695144" ], "products": [ "species_10695146" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10724718": { "compartment": "compartment_876", "id": "reaction_10724718", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10675991": { "compartment": "compartment_7660", "id": "reaction_10675991", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675987", "species_10675982" ], "products": [ "species_10675989" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q54S00", "DDB_G0282747", "Q55AZ3", "DDB_G0271608" ] }, "reaction_10703141": { "compartment": "compartment_7660", "id": "reaction_10703141", "reactome": "R-DDI-5653766", "name": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703137", "species_10703104" ], "products": [ "species_10703139" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "O96612", "DDB_G0275021", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10675750": { "compartment": "compartment_70101", "id": "reaction_10675750", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10677294": { "compartment": "compartment_70616", "id": "reaction_10677294", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10677291", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10686888": { "compartment": "compartment_70101", "id": "reaction_10686888", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686865": { "compartment": "compartment_70101", "id": "reaction_10686865", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675741": { "compartment": "compartment_70101", "id": "reaction_10675741", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686918": { "compartment": "compartment_20699", "id": "reaction_10686918", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10686876": { "compartment": "compartment_70101", "id": "reaction_10686876", "reactome": "R-DDI-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10686873", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686884": { "compartment": "compartment_20699", "id": "reaction_10686884", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10686881", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10687053": { "compartment": "compartment_876", "id": "reaction_10687053", "reactome": "R-DDI-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10687050", "catalyst" ] ], "additional_components": [ "species_209937", "species_176667", "species_209937", "species_176667", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10686921": { "compartment": "compartment_20699", "id": "reaction_10686921", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10675743": { "compartment": "compartment_70101", "id": "reaction_10675743", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675748": { "compartment": "compartment_70101", "id": "reaction_10675748", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10682847": { "compartment": "compartment_876", "id": "reaction_10682847", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682581": { "compartment": "compartment_876", "id": "reaction_10682581", "reactome": "R-DDI-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10682578", "catalyst" ] ], "additional_components": [ "species_351993", "species_29500", "species_352030", "species_351993", "species_29500", "species_352030", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10682845": { "compartment": "compartment_876", "id": "reaction_10682845", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682842", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "DDB_G0279983" ] }, "reaction_10682821": { "compartment": "compartment_876", "id": "reaction_10682821", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682840": { "compartment": "compartment_876", "id": "reaction_10682840", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682837", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10722317": { "compartment": "compartment_7660", "id": "reaction_10722317", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690002" ], "products": [ "species_10722315" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722398": { "compartment": "compartment_7660", "id": "reaction_10722398", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722315", "species_10722394" ], "products": [ "species_10722396" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54JZ0", "DDB_G0287727", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722387": { "compartment": "compartment_7660", "id": "reaction_10722387", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690004" ], "products": [ "species_10722385" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722987": { "compartment": "compartment_7660", "id": "reaction_10722987", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10722313" ], "products": [ "species_113582", "species_10722985" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10688476": { "compartment": "compartment_7660", "id": "reaction_10688476", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688251", "species_10688256" ], "products": [ "species_10688474" ], "modifiers": [], "additional_components": [ "DDB_G0285989", "DDB_G0281085", "Q54UG9", "DDB_G0281085", "Q54MF7", "DDB_G0285989" ] }, "reaction_10709807": { "compartment": "compartment_7660", "id": "reaction_10709807", "reactome": "R-DDI-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704976", "species_29358" ], "products": [ "species_113582", "species_10709804", "species_10682355" ], "modifiers": [ [ "species_10704976", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703096": { "compartment": "compartment_7660", "id": "reaction_10703096", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703089" ], "products": [ "species_10703093" ], "modifiers": [ [ "species_10703089", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10709844": { "compartment": "compartment_7660", "id": "reaction_10709844", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709797", "species_10705273" ], "products": [ "species_10709799" ], "modifiers": [], "additional_components": [ "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10702975": { "compartment": "compartment_7660", "id": "reaction_10702975", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10702970" ], "products": [ "species_10702972", "species_113550" ], "modifiers": [ [ "species_10702970", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705284": { "compartment": "compartment_7660", "id": "reaction_10705284", "reactome": "R-DDI-5682967", "name": "WHSC1 binds DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700897", "species_10705275" ], "products": [ "species_10705282" ], "modifiers": [], "additional_components": [ "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676006": { "compartment": "compartment_7660", "id": "reaction_10676006", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675974", "species_10675996" ], "products": [ "species_10675968", "species_10675998" ], "modifiers": [], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "DDB_G0277701", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10703099": { "compartment": "compartment_7660", "id": "reaction_10703099", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10703074" ], "products": [ "species_10703028", "species_5651834" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10711334": { "compartment": "compartment_7660", "id": "reaction_10711334", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709581", "species_10711318" ], "products": [ "species_10698305", "species_10711329" ], "modifiers": [ [ "species_10711331", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q869L7", "DDB_G0279421", "Q54TK0", "DDB_G0281703", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54SX2", "DDB_G0282161", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710378": { "compartment": "compartment_7660", "id": "reaction_10710378", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710373", "species_113518" ], "products": [ "species_10675845", "species_10669917" ], "modifiers": [ [ "species_10710375", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0267682", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0274207" ] }, "reaction_10725845": { "compartment": "compartment_7660", "id": "reaction_10725845", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710820", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10710831" ], "modifiers": [ [ "species_10710820", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10674796": { "compartment": "compartment_7660", "id": "reaction_10674796", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674787", "species_10674792" ], "products": [ "species_10674794" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54BN2", "DDB_G0293546" ] }, "reaction_10710837": { "compartment": "compartment_7660", "id": "reaction_10710837", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710833", "species_10675852" ], "products": [ "species_10710835" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709584": { "compartment": "compartment_7660", "id": "reaction_10709584", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709577", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10709581" ], "modifiers": [ [ "species_10709577", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10710592": { "compartment": "compartment_7660", "id": "reaction_10710592", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710586", "species_10703028" ], "products": [ "species_10710588" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10674087": { "compartment": "compartment_7660", "id": "reaction_10674087", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674080" ], "products": [ "species_10674084" ], "modifiers": [ [ "species_10674080", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10705287": { "compartment": "compartment_7660", "id": "reaction_10705287", "reactome": "R-DDI-5682983", "name": "ATM phosphorylates WHSC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705282" ], "products": [ "species_113582", "species_10705277" ], "modifiers": [ [ "species_10705282", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709814": { "compartment": "compartment_7660", "id": "reaction_10709814", "reactome": "R-DDI-5693566", "name": "TP53BP1 associates with H4K20Me2 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705317", "species_10698412" ], "products": [ "species_10705325" ], "modifiers": [], "additional_components": [ "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0286539", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676004": { "compartment": "compartment_7660", "id": "reaction_10676004", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675996", "species_10675953" ], "products": [ "species_10675947", "species_10675998" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10705333": { "compartment": "compartment_7660", "id": "reaction_10705333", "reactome": "R-DDI-5683425", "name": "ATM phosphorylates TP53BP1 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705325", "species_29358" ], "products": [ "species_113582", "species_10705323" ], "modifiers": [ [ "species_10705325", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10710857": { "compartment": "compartment_7660", "id": "reaction_10710857", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710853", "species_10710851", "species_10670546", "species_10710839" ], "products": [ "species_10710855" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54RD4", "DDB_G0283189", "Q54KS3", "DDB_G0287149", "Q54Y85", "DDB_G0278367", "Q54TN8", "DDB_G0281641", "Q7KWN0", "DDB_G0272740", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q75JQ9", "DDB_G0272222", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q54N41", "DDB_G0285521", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54BN3", "DDB_G0293702", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q54Y85", "DDB_G0278367", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54RD4", "DDB_G0283189", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54ST4", "DDB_G0282235", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10709802": { "compartment": "compartment_7660", "id": "reaction_10709802", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709799" ], "products": [ "species_113582", "species_10705275" ], "modifiers": [ [ "species_10709799", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10676017": { "compartment": "compartment_7660", "id": "reaction_10676017", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010", "species_10674064" ], "products": [ "species_10676015" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10703020": { "compartment": "compartment_7660", "id": "reaction_10703020", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676029", "species_10674064" ], "products": [ "species_10676031" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10676000": { "compartment": "compartment_7660", "id": "reaction_10676000", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675902", "species_10675996" ], "products": [ "species_10675896", "species_10675998" ], "modifiers": [], "additional_components": [ "P53766", "DDB_G0277877", "DDB_G0277701", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10703083": { "compartment": "compartment_7660", "id": "reaction_10703083", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703076" ], "products": [ "species_10703074", "species_10703081" ], "modifiers": [], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10709648": { "compartment": "compartment_7660", "id": "reaction_10709648", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10709644", "species_10709590" ], "products": [ "species_10709646", "species_10709642" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10710842": { "compartment": "compartment_7660", "id": "reaction_10710842", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710835" ], "products": [ "species_10710839" ], "modifiers": [ [ "species_10710835", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10676020": { "compartment": "compartment_7660", "id": "reaction_10676020", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676015" ], "products": [ "species_10675996", "species_10674091", "species_30977" ], "modifiers": [ [ "species_10676015", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10705280": { "compartment": "compartment_7660", "id": "reaction_10705280", "reactome": "R-DDI-5682965", "name": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705277", "species_77087" ], "products": [ "species_10705231", "species_77502" ], "modifiers": [ [ "species_10705277", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10675854": { "compartment": "compartment_7660", "id": "reaction_10675854", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675845", "species_10675850" ], "products": [ "species_10675852" ], "modifiers": [], "additional_components": [ "DDB_G0267682", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10703037": { "compartment": "compartment_7660", "id": "reaction_10703037", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676035", "species_10703028", "species_10670606" ], "products": [ "species_10703030", "species_10675996" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0284987", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "DDB_G0277701", "DDB_G0277943" ] }, "reaction_10725405": { "compartment": "compartment_70101", "id": "reaction_10725405", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725401" ], "products": [ "species_10725403" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10709812": { "compartment": "compartment_7660", "id": "reaction_10709812", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709809" ], "products": [ "species_113582", "species_10705388" ], "modifiers": [ [ "species_10709809", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10703045": { "compartment": "compartment_7660", "id": "reaction_10703045", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10703030" ], "products": [ "species_10703042", "species_113541" ], "modifiers": [ [ "species_10703030", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10676013": { "compartment": "compartment_7660", "id": "reaction_10676013", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675998" ], "products": [ "species_10676010" ], "modifiers": [ [ "species_10675998", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10702985": { "compartment": "compartment_7660", "id": "reaction_10702985", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702977" ], "products": [ "species_10702982" ], "modifiers": [ [ "species_10702977", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705330": { "compartment": "compartment_7660", "id": "reaction_10705330", "reactome": "R-DDI-5683405", "name": "PPP5C dephosphorylates TP53BP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705323" ], "products": [ "species_10705325", "species_113550" ], "modifiers": [ [ "species_10705327", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0283157" ] }, "reaction_10702980": { "compartment": "compartment_7660", "id": "reaction_10702980", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702972", "species_30555" ], "products": [ "species_113541", "species_10702977" ], "modifiers": [ [ "species_10702972", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10703079": { "compartment": "compartment_7660", "id": "reaction_10703079", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10703042" ], "products": [ "species_10703076", "species_427497" ], "modifiers": [ [ "species_10703042", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10710590": { "compartment": "compartment_7660", "id": "reaction_10710590", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710588", "species_427523" ], "products": [ "species_427497", "species_10709573" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10705265": { "compartment": "compartment_7660", "id": "reaction_10705265", "reactome": "R-DDI-5682629", "name": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705253", "species_10705259" ], "products": [ "species_10705263" ], "modifiers": [], "additional_components": [ "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54D06", "DDB_G0292596", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709592": { "compartment": "compartment_7660", "id": "reaction_10709592", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709562", "species_10700619", "species_10700558" ], "products": [ "species_10709590" ], "modifiers": [], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54WU9", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10709847": { "compartment": "compartment_7660", "id": "reaction_10709847", "reactome": "R-DDI-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709804", "species_29358" ], "products": [ "species_113582", "species_10705206" ], "modifiers": [ [ "species_10709804", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703207": { "compartment": "compartment_7660", "id": "reaction_10703207", "reactome": "R-DDI-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703190" ], "products": [ "species_10703202", "species_10703204", "species_10703188" ], "modifiers": [ [ "species_10703190", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "DDB_G0290453", "DDB_G0290453", "DDB_G0277533", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453" ] }, "reaction_10676002": { "compartment": "compartment_7660", "id": "reaction_10676002", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675918", "species_10675996" ], "products": [ "species_10675889", "species_10675998" ], "modifiers": [], "additional_components": [ "Q86K43", "DDB_G0277247", "DDB_G0277701", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10703022": { "compartment": "compartment_7660", "id": "reaction_10703022", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010" ], "products": [ "species_10676029" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10676038": { "compartment": "compartment_7660", "id": "reaction_10676038", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676031", "species_30555" ], "products": [ "species_10676035", "species_113541" ], "modifiers": [ [ "species_10676031", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10709851": { "compartment": "compartment_7660", "id": "reaction_10709851", "reactome": "R-DDI-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705374", "species_10705206" ], "products": [ "species_10709809" ], "modifiers": [], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10674096": { "compartment": "compartment_7660", "id": "reaction_10674096", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10674093" ], "products": [ "species_113541", "species_10674080" ], "modifiers": [ [ "species_10674093", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710877": { "compartment": "compartment_7660", "id": "reaction_10710877", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709646", "species_10669917" ], "products": [ "species_10710586" ], "modifiers": [ [ "species_10709646", "catalyst" ] ], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357" ] }, "reaction_10704979": { "compartment": "compartment_7660", "id": "reaction_10704979", "reactome": "R-DDI-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704974", "species_113560" ], "products": [ "species_2485002", "species_10704976" ], "modifiers": [ [ "species_10704974", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703091": { "compartment": "compartment_7660", "id": "reaction_10703091", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703087", "species_10670614" ], "products": [ "species_10703089" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10710823": { "compartment": "compartment_7660", "id": "reaction_10710823", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10710797" ], "products": [ "species_113582", "species_10710820", "species_113550" ], "modifiers": [ [ "species_10710797", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709588": { "compartment": "compartment_7660", "id": "reaction_10709588", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10709573" ], "products": [ "species_10709586" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10676022": { "compartment": "compartment_7660", "id": "reaction_10676022", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674078", "species_10674091" ], "products": [ "species_10674093" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710849": { "compartment": "compartment_7660", "id": "reaction_10710849", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10710844" ], "products": [ "species_10710846", "species_113541" ], "modifiers": [ [ "species_10710844", "catalyst" ] ], "additional_components": [ "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10682781": { "compartment": "compartment_70101", "id": "reaction_10682781", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_5279533" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10681988": { "compartment": "compartment_70101", "id": "reaction_10681988", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10681985" ], "products": [ "species_10681963" ], "modifiers": [ [ "species_10681985", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "species_113552", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043" ] }, "reaction_10687261": { "compartment": "compartment_5460", "id": "reaction_10687261", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10687258", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q55FI1", "DDB_G0268104" ] }, "reaction_10724738": { "compartment": "compartment_876", "id": "reaction_10724738", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10682758" ], "products": [ "species_10682761" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10724723": { "compartment": "compartment_70101", "id": "reaction_10724723", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10724720", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10725941": { "compartment": "compartment_70101", "id": "reaction_10725941", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10725938", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10684216": { "compartment": "compartment_876", "id": "reaction_10684216", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684051" ], "products": [ "species_10684213" ], "modifiers": [ [ "species_10684051", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438" ] }, "reaction_10712040": { "compartment": "compartment_876", "id": "reaction_10712040", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10712037", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10683869": { "compartment": "compartment_876", "id": "reaction_10683869", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10683865" ], "products": [ "species_10683867" ], "modifiers": [], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10725991": { "compartment": "compartment_70101", "id": "reaction_10725991", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10722710": { "compartment": "compartment_876", "id": "reaction_10722710", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722706", "species_10683865" ], "products": [ "species_10722708" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684207": { "compartment": "compartment_70101", "id": "reaction_10684207", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10684204", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10683912": { "compartment": "compartment_70101", "id": "reaction_10683912", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683909", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P36408", "DDB_G0277143", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10724275": { "compartment": "compartment_70101", "id": "reaction_10724275", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825", "species_10683777" ], "products": [ "species_10724273" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10722760": { "compartment": "compartment_876", "id": "reaction_10722760", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722758" ], "products": [ "species_10722706", "species_10686923" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10722770": { "compartment": "compartment_876", "id": "reaction_10722770", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722708" ], "products": [ "species_10722758", "species_29372" ], "modifiers": [ [ "species_10722708", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10698635": { "compartment": "compartment_70101", "id": "reaction_10698635", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10698631" ], "products": [ "species_10698633" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "species_874088", "Q54BN2", "DDB_G0293546" ] }, "reaction_10723428": { "compartment": "compartment_70101", "id": "reaction_10723428", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698604", "species_8982080" ], "products": [ "species_10723426" ], "modifiers": [], "additional_components": [ "DDB_G0287361", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q54KG1", "DDB_G0287361" ] }, "reaction_10682899": { "compartment": "compartment_70101", "id": "reaction_10682899", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682888", "species_10682859" ], "products": [ "species_10682853", "species_10682894", "species_10682859" ], "modifiers": [ [ "species_10682896", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q55GN5", "DDB_G0267590", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10702014": { "compartment": "compartment_263163", "id": "reaction_10702014", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10702010" ], "products": [ "species_10702012" ], "modifiers": [], "additional_components": [ "B0G185", "DDB_G0295711", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031", "B0G185", "DDB_G0295711", "species_1806205", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031" ] }, "reaction_10682916": { "compartment": "compartment_876", "id": "reaction_10682916", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682905", "species_10682853", "species_10682859" ], "products": [ "species_10682911", "species_10682853", "species_10682859" ], "modifiers": [ [ "species_10682913", "catalyst" ] ], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10682453": { "compartment": "compartment_70101", "id": "reaction_10682453", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682429", "species_29438" ], "products": [ "species_10682433", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "species_29420", "O00909", "DDB_G0289173", "O00909", "DDB_G0289173", "species_29438", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10682882": { "compartment": "compartment_70101", "id": "reaction_10682882", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682871", "species_10682859" ], "products": [ "species_10682853", "species_10682859", "species_10682877" ], "modifiers": [ [ "species_10682879", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951" ] }, "reaction_10701766": { "compartment": "compartment_171907", "id": "reaction_10701766", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701749" ], "products": [ "species_10701763" ], "modifiers": [ [ "species_10701749", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10679542": { "compartment": "compartment_984", "id": "reaction_10679542", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679281": { "compartment": "compartment_984", "id": "reaction_10679281", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10722325": { "compartment": "compartment_7660", "id": "reaction_10722325", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953383", "species_8953399" ], "modifiers": [ [ "species_10722322", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10679278": { "compartment": "compartment_984", "id": "reaction_10679278", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679538": { "compartment": "compartment_984", "id": "reaction_10679538", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679540": { "compartment": "compartment_984", "id": "reaction_10679540", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10703366": { "compartment": "compartment_984", "id": "reaction_10703366", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679288": { "compartment": "compartment_984", "id": "reaction_10679288", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10695627": { "compartment": "compartment_876", "id": "reaction_10695627", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10695624", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "Q54WR4", "DDB_G0279483" ] }, "reaction_10695602": { "compartment": "compartment_876", "id": "reaction_10695602", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10695599", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10718995": { "compartment": "compartment_876", "id": "reaction_10718995", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692772", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10718847": { "compartment": "compartment_876", "id": "reaction_10718847", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718843", "species_10718837" ], "products": [ "species_10718845" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10720418": { "compartment": "compartment_876", "id": "reaction_10720418", "reactome": "R-DDI-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_179856" ], "products": [ "species_10718325" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718711": { "compartment": "compartment_70101", "id": "reaction_10718711", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718707", "species_10718699" ], "products": [ "species_10718709" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10718568": { "compartment": "compartment_70101", "id": "reaction_10718568", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718564", "species_10718544", "species_10718532" ], "products": [ "species_10718566" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10718522": { "compartment": "compartment_876", "id": "reaction_10718522", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718315", "species_10681832", "species_10718335", "species_10718319", "species_10718325", "species_10718317" ], "products": [ "species_10718337" ], "modifiers": [], "additional_components": [ "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718577": { "compartment": "compartment_70101", "id": "reaction_10718577", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709499", "species_10718570" ], "products": [ "species_10718532" ], "modifiers": [], "additional_components": [ "DDB_G0278711", "DDB_G0277139", "DDB_G0277139" ] }, "reaction_10718347": { "compartment": "compartment_876", "id": "reaction_10718347", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_10718337", "species_10718343", "species_10718275" ], "products": [ "species_10718345" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10719091": { "compartment": "compartment_24339", "id": "reaction_10719091", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719089", "species_10719055" ], "products": [ "species_10719087" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102", "species_113592", "P36415", "DDB_G0269144", "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "P36415", "DDB_G0269144", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102" ] }, "reaction_10718357": { "compartment": "compartment_876", "id": "reaction_10718357", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718345", "species_113592" ], "products": [ "species_29370", "species_10718354" ], "modifiers": [ [ "species_10718345", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718998": { "compartment": "compartment_876", "id": "reaction_10718998", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10718914", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q54S78", "DDB_G0282625", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "P54673", "DDB_G0278727", "Q75JD4", "DDB_G0274695", "P54675", "DDB_G0275011", "Q54U74", "DDB_G0281235", "Q9BKJ9", "DDB_G0287035", "Q54VV7", "DDB_G0280111", "Q54GB3", "DDB_G0290363", "P25870", "DDB_G0277221", "Q54Y50", "DDB_G0278685", "Q54X82", "DDB_G0279141", "Q6TMJ9", "DDB_G0280061", "Q54UC8", "DDB_G0281155", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718721": { "compartment": "compartment_876", "id": "reaction_10718721", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10718715" ], "products": [ "species_10718717" ], "modifiers": [ [ "species_10718719", "inhibitor" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q9BKJ9", "DDB_G0287035", "Q54UC8", "DDB_G0281155", "Q9BKJ9", "DDB_G0287035", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54UC8", "DDB_G0281155", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10718575": { "compartment": "compartment_70101", "id": "reaction_10718575", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718566" ], "products": [ "species_10718564", "species_10718544", "species_10709499", "species_10718570" ], "modifiers": [ [ "species_10718566", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0278711", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10725842": { "compartment": "compartment_70101", "id": "reaction_10725842", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_9648300" ], "products": [ "species_10718719" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10698195": { "compartment": "compartment_70101", "id": "reaction_10698195", "reactome": "R-DDI-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698192", "catalyst" ] ], "additional_components": [ "DDB_G0290313" ] }, "reaction_10698213": { "compartment": "compartment_70101", "id": "reaction_10698213", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_29372" ], "products": [ "species_2892454", "species_113551" ], "modifiers": [ [ "species_10698210", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10698117": { "compartment": "compartment_70101", "id": "reaction_10698117", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698114", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698178": { "compartment": "compartment_70101", "id": "reaction_10698178", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698175", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10698125": { "compartment": "compartment_70101", "id": "reaction_10698125", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10698122", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10698190": { "compartment": "compartment_70101", "id": "reaction_10698190", "reactome": "R-DDI-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698187", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54G87", "DDB_G0290313" ] }, "reaction_10698982": { "compartment": "compartment_70101", "id": "reaction_10698982", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10698913", "catalyst" ], [ "species_10698980", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10725463": { "compartment": "compartment_70101", "id": "reaction_10725463", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698070", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698204": { "compartment": "compartment_70101", "id": "reaction_10698204", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10698201", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10685792": { "compartment": "compartment_876", "id": "reaction_10685792", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685018": { "compartment": "compartment_876", "id": "reaction_10685018", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10685015", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10685539": { "compartment": "compartment_876", "id": "reaction_10685539", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10685536", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10685554": { "compartment": "compartment_876", "id": "reaction_10685554", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685476": { "compartment": "compartment_876", "id": "reaction_10685476", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10685473", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10685794": { "compartment": "compartment_876", "id": "reaction_10685794", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10722613": { "compartment": "compartment_70101", "id": "reaction_10722613", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10722610", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685568": { "compartment": "compartment_876", "id": "reaction_10685568", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10685434": { "compartment": "compartment_876", "id": "reaction_10685434", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10685431", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10685563": { "compartment": "compartment_876", "id": "reaction_10685563", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685429": { "compartment": "compartment_172574", "id": "reaction_10685429", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10685426", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_29418", "species_29426", "species_71067", "species_29418", "DDB_G0276973" ] }, "reaction_10685421": { "compartment": "compartment_876", "id": "reaction_10685421", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_446589", "species_351626" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10685418", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10687849": { "compartment": "compartment_70101", "id": "reaction_10687849", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"DDB_G0277907", "Q54MZ5", "DDB_G0285597", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "Q55E21", "DDB_G0270866", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q54G90", "DDB_G0290307", "Q55BS9", "DDB_G0270380", "species_29420", "Q55D61", "DDB_G0269192", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X51", "DDB_G0279207", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54NG2", "DDB_G0285277", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q9BMX0", "DDB_G0288613", "Q55A46", "DDB_G0272108", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54ME8", "DDB_G0286007", "Q54J50", "DDB_G0288295", "Q7YZN9", "DDB_G0277919", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q75JP6", "DDB_G0272470", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q54KR9", "DDB_G0287197", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "Q54I89", "DDB_G0288923", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q55BN7", "DDB_G0270424", "Q54DH9", "DDB_G0292240", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "Q55D17", "DDB_G0269814", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q1ZXC2", "DDB_G0290745", "P22683", "DDB_G0283393", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984" ] }, "reaction_10675713": { "compartment": "compartment_7660", "id": "reaction_10675713", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675707", "species_10675016" ], "products": [ "species_10675711" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405" ] }, "reaction_10675717": { "compartment": "compartment_7660", "id": "reaction_10675717", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675711" ], "products": [ "species_10675715" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10675709": { "compartment": "compartment_7660", "id": "reaction_10675709", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83747", "species_10675045" ], "products": [ "species_10675707" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127" ] }, "reaction_10679857": { "compartment": "compartment_13231", "id": "reaction_10679857", "reactome": "R-DDI-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677717" ], "products": [ "species_10679855" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10681841": { "compartment": "compartment_70101", "id": "reaction_10681841", "reactome": "R-DDI-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [ [ "species_10681384", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10681837": { "compartment": "compartment_70101", "id": "reaction_10681837", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681382" ], "products": [ "species_10681384", "species_29420" ], "modifiers": [ [ "species_10681834", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_111349", "P34144", "DDB_G0277869", "species_29438", "Q54F64", "DDB_G0291085", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q86HN1", "DDB_G0293396", "Q8IS12", "DDB_G0275703", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "Q54DW4", "DDB_G0291978", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q54B37", "DDB_G0293978", "Q8IS16", "DDB_G0276963", "Q55G61", "DDB_G0268354", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q1ZX99", "DDB_G0293928", "Q55FD8", "DDB_G0268578", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10704220": { "compartment": "compartment_876", "id": "reaction_10704220", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704091", "species_10678454" ], "products": [ "species_10704218" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704343": { "compartment": "compartment_876", "id": "reaction_10704343", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704339", "species_10704334" ], "products": [ "species_10704341" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q54QK0", "DDB_G0283803", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10704230": { "compartment": "compartment_876", "id": "reaction_10704230", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10704218" ], "products": [ "species_10704227" ], "modifiers": [ [ "species_10704218", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703817": { "compartment": "compartment_876", "id": "reaction_10703817", "reactome": "R-DDI-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703808", "species_10678454" ], "products": [ "species_10703810" ], "modifiers": [ [ "species_10703815", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0290123" ] }, "reaction_10725190": { "compartment": "compartment_70101", "id": "reaction_10725190", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725136", "species_2530486" ], "products": [ "species_10725178", "species_111294" ], "modifiers": [ [ "species_10725185", "catalyst" ], [ "species_10725188", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10704105": { "compartment": "compartment_876", "id": "reaction_10704105", "reactome": "R-DDI-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703810", "species_10704084" ], "products": [ "species_10704086" ], "modifiers": [ [ "species_10704103", "catalyst" ], [ "species_10704093", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10725346": { "compartment": "compartment_876", "id": "reaction_10725346", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678450", "species_10676232" ], "products": [ "species_10725344" ], "modifiers": [ [ "species_10725342", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725393": { "compartment": "compartment_876", "id": "reaction_10725393", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725344" ], "products": [ "species_10725391" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "species_74016", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "Q7Z2B8", "DDB_G0277917", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703913": { "compartment": "compartment_70101", "id": "reaction_10703913", "reactome": "R-DDI-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703911" ], "products": [ "species_10674713", "species_10703909" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703705": { "compartment": "compartment_70101", "id": "reaction_10703705", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_113592" ], "products": [ "species_29370", "species_10703702" ], "modifiers": [ [ "species_10703686", "catalyst" ] ], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10704378": { "compartment": "compartment_876", "id": "reaction_10704378", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10704334" ], "products": [ "species_10704355", "species_29372" ], "modifiers": [ [ "species_10704375", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0283157" ] }, "reaction_10725283": { "compartment": "compartment_70101", "id": "reaction_10725283", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725185", "species_9653479" ], "products": [ "species_10725188" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10703885": { "compartment": "compartment_70101", "id": "reaction_10703885", "reactome": "R-DDI-5672957", "name": "PP2A dephosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703868", "species_29356" ], "products": [ "species_10703882", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10703358": { "compartment": "compartment_70101", "id": "reaction_10703358", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10703324" ], "products": [ "species_10703353" ], "modifiers": [ [ "species_10703355", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10725301": { "compartment": "compartment_876", "id": "reaction_10725301", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725255", "species_29356" ], "products": [ "species_10678450", "species_8848337" ], "modifiers": [ [ "species_10725294", "catalyst" ], [ "species_10725296", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10725093": { "compartment": "compartment_12045", "id": "reaction_10725093", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725069", "species_71284" ], "products": [ "species_10725089", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ], [ "species_10725091", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "species_29426", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "pubchem.compound:6918831" ] }, "reaction_10725304": { "compartment": "compartment_12045", "id": "reaction_10725304", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089" ], "products": [ "species_10678450" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703887": { "compartment": "compartment_70101", "id": "reaction_10703887", "reactome": "R-DDI-5672958", "name": "YWHAB dimer dissociates from KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703882" ], "products": [ "species_10703880", "species_10674713" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138" ] }, "reaction_10725460": { "compartment": "compartment_876", "id": "reaction_10725460", "reactome": "R-DDI-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10725457", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "O15757", "DDB_G0275619", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54HA8", "DDB_G0289585", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704222": { "compartment": "compartment_70101", "id": "reaction_10704222", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_10704091" ], "products": [ "species_10704093" ], "modifiers": [], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "DDB_G0270200", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703915": { "compartment": "compartment_70101", "id": "reaction_10703915", "reactome": "R-DDI-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10704272": { "compartment": "compartment_20699", "id": "reaction_10704272", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10704268" ], "products": [ "species_10704270" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54B86", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54HC6", "DDB_G0289555", "Q54B86", "DDB_G0293838", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54XX5", "DDB_G0278535", "Q54CB4", "DDB_G0293838" ] }, "reaction_10725637": { "compartment": "compartment_876", "id": "reaction_10725637", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725633", "species_10725631" ], "products": [ "species_10725635" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54VD5", "DDB_G0280437", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "species_29438", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725306": { "compartment": "compartment_876", "id": "reaction_10725306", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678452", "species_29420" ], "products": [ "species_10679153" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703364": { "compartment": "compartment_876", "id": "reaction_10703364", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703308", "species_10703322" ], "products": [ "species_10703324" ], "modifiers": [], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10725369": { "compartment": "compartment_17906", "id": "reaction_10725369", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725342" ], "products": [ "species_10725367" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725313": { "compartment": "compartment_876", "id": "reaction_10725313", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10704086" ], "products": [ "species_10704209" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10725257": { "compartment": "compartment_876", "id": "reaction_10725257", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725253" ], "products": [ "species_10725255" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725298": { "compartment": "compartment_876", "id": "reaction_10725298", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10725294" ], "products": [ "species_10725296" ], "modifiers": [], "additional_components": [ "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10704082": { "compartment": "compartment_876", "id": "reaction_10704082", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10704079", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725281": { "compartment": "compartment_20699", "id": "reaction_10725281", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089", "species_200993" ], "products": [ "species_76194", "species_10725253" ], "modifiers": [ [ "species_10725278", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54PF0", "DDB_G0284603", "Q557H5", "DDB_G0284603", "Q550I3", "DDB_G0277093", "Q550R7", "DDB_G0284603" ] }, "reaction_10703362": { "compartment": "compartment_876", "id": "reaction_10703362", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703326", "species_10678454" ], "products": [ "species_10703328" ], "modifiers": [], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10704369": { "compartment": "compartment_876", "id": "reaction_10704369", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704355", "species_29356" ], "products": [ "species_10704367", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ], [ "species_10704306", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703360": { "compartment": "compartment_70101", "id": "reaction_10703360", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703353" ], "products": [ "species_10703308" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703870": { "compartment": "compartment_70101", "id": "reaction_10703870", "reactome": "R-DDI-5672954", "name": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674713", "species_10703702" ], "products": [ "species_10703868" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703866": { "compartment": "compartment_70101", "id": "reaction_10703866", "reactome": "R-DDI-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10674713" ], "products": [ "species_10703864" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703331": { "compartment": "compartment_876", "id": "reaction_10703331", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703328" ], "products": [ "species_10703326", "species_10679153" ], "modifiers": [ [ "species_10703328", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10725311": { "compartment": "compartment_876", "id": "reaction_10725311", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678454" ], "products": [ "species_10679153" ], "modifiers": [ [ "species_10678454", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725308": { "compartment": "compartment_876", "id": "reaction_10725308", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10676462": { "compartment": "compartment_7660", "id": "reaction_10676462", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676308", "species_10676297" ], "products": [ "species_10676310" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10676470": { "compartment": "compartment_7660", "id": "reaction_10676470", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676446" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676448": { "compartment": "compartment_7660", "id": "reaction_10676448", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676446" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676452": { "compartment": "compartment_7660", "id": "reaction_10676452", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676450" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674872": { "compartment": "compartment_7660", "id": "reaction_10674872", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674862" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674197": { "compartment": "compartment_7660", "id": "reaction_10674197", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674195" ], "products": [ "species_10674193", "species_109877", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10676460": { "compartment": "compartment_7660", "id": "reaction_10676460", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676365", "species_10676370" ], "products": [ "species_10676372" ], "modifiers": [], "additional_components": [ "DDB_G0290331", "DDB_G0282677", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331" ] }, "reaction_10676464": { "compartment": "compartment_7660", "id": "reaction_10676464", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676331", "species_10675598" ], "products": [ "species_10676333" ], "modifiers": [], "additional_components": [ "DDB_G0285293", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10674956": { "compartment": "compartment_7660", "id": "reaction_10674956", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674954" ], "products": [ "species_10674193", "species_10673970", "species_75897", "species_10672167" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676468": { "compartment": "compartment_7660", "id": "reaction_10676468", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676380" ], "products": [ "species_10676380" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676474": { "compartment": "compartment_7660", "id": "reaction_10676474", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676476": { "compartment": "compartment_7660", "id": "reaction_10676476", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674860": { "compartment": "compartment_7660", "id": "reaction_10674860", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674858" ], "products": [ "species_10674193", "species_110068", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10724807": { "compartment": "compartment_17938", "id": "reaction_10724807", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724887", "species_10677461" ], "products": [ "species_10724894" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "Q54D08", "DDB_G0292592", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091" ] }, "reaction_10724881": { "compartment": "compartment_17938", "id": "reaction_10724881", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_10724875" ], "products": [ "species_10724877", "species_10724879" ], "modifiers": [], "additional_components": [ "Q54UN5", "DDB_G0280947", "Q54WU6", "DDB_G0279427", "Q54JS5", "DDB_G0287817", "Q55BD9", "DDB_G0271288", "Q551B5", "DDB_G0276673", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54XA2", "DDB_G0279099", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54UN5", "DDB_G0280947", "Q54JS5", "DDB_G0287817", "Q551B5", "DDB_G0276673", "Q55BD9", "DDB_G0271288", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q86K39", "DDB_G0277257", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54XA2", "DDB_G0279099", "Q54WU6", "DDB_G0279427", "species_29588" ] }, "reaction_10724892": { "compartment": "compartment_17938", "id": "reaction_10724892", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10724885" ], "products": [ "species_10724889", "species_29420" ], "modifiers": [ [ "species_10724885", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701" ] }, "reaction_10724992": { "compartment": "compartment_17938", "id": "reaction_10724992", "reactome": "R-DDI-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724800" ], "products": [ "species_10724804", "species_29372" ], "modifiers": [ [ "species_10724800", "catalyst" ], [ "species_10724990", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54HT9", "DDB_G0289243", "Q54UF2", "DDB_G0281111" ] }, "reaction_10726077": { "compartment": "compartment_12045", "id": "reaction_10726077", "reactome": "R-DDI-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10683360" ], "products": [ "species_10683368" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10726080": { "compartment": "compartment_12045", "id": "reaction_10726080", "reactome": "R-DDI-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10683368", "catalyst" ] ], "additional_components": [ "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10702919": { "compartment": "compartment_7660", "id": "reaction_10702919", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702917" ], "products": [ "species_10669917", "species_10702915" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10702926": { "compartment": "compartment_7660", "id": "reaction_10702926", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702923", "species_10669917" ], "products": [ "species_10702917" ], "modifiers": [ [ "species_10702923", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428" ] }, "reaction_10687980": { "compartment": "compartment_70101", "id": "reaction_10687980", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687942", "species_10687976" ], "products": [ "species_10687978" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q86L44", "DDB_G0294407", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10686695": { "compartment": "compartment_876", "id": "reaction_10686695", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10686697": { "compartment": "compartment_876", "id": "reaction_10686697", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10680301": { "compartment": "compartment_70101", "id": "reaction_10680301", "reactome": "R-DDI-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_10680289", "species_29372" ], "modifiers": [ [ "species_10680298", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54AX5", "DDB_G0294094", "species_29418" ] }, "reaction_10680303": { "compartment": "compartment_876", "id": "reaction_10680303", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680166", "species_10680149" ], "products": [ "species_10680168" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10718529": { "compartment": "compartment_984", "id": "reaction_10718529", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718524", "species_109276" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10718524", "catalyst" ] ], "additional_components": [ "Q54XV8", "DDB_G0278563", "species_6789198", "species_1236719", "CHEBI:21615", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10715120": { "compartment": "compartment_984", "id": "reaction_10715120", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677636", "species_6803081" ], "products": [ "species_10715118" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_6803081" ] }, "reaction_10718526": { "compartment": "compartment_984", "id": "reaction_10718526", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712951", "species_6789198" ], "products": [ "species_10718524" ], "modifiers": [], "additional_components": [ "DDB_G0278563", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10700306": { "compartment": "compartment_7660", "id": "reaction_10700306", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700290" ], "products": [ "species_10700304" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10700369": { "compartment": "compartment_70101", "id": "reaction_10700369", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700363" ], "products": [ "species_10700367" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10700238": { "compartment": "compartment_70101", "id": "reaction_10700238", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10700235", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "B0G0Y8", "DDB_G0268634", "species_29438" ] }, "reaction_10702112": { "compartment": "compartment_70101", "id": "reaction_10702112", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10702109", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10684759": { "compartment": "compartment_876", "id": "reaction_10684759", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10684756", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10684628": { "compartment": "compartment_20699", "id": "reaction_10684628", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10684625", "catalyst" ] ], "additional_components": [ "DDB_G0281877" ] }, "reaction_10722684": { "compartment": "compartment_70101", "id": "reaction_10722684", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722681", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720523": { "compartment": "compartment_70101", "id": "reaction_10720523", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10720520", "catalyst" ] ], "additional_components": [ "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10720514": { "compartment": "compartment_70101", "id": "reaction_10720514", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10720511", "catalyst" ] ], "additional_components": [ "DDB_G0276663" ] }, "reaction_10684806": { "compartment": "compartment_201753", "id": "reaction_10684806", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10684803", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10684991": { "compartment": "compartment_876", "id": "reaction_10684991", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10684988", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684892": { "compartment": "compartment_876", "id": "reaction_10684892", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10684889", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10722668": { "compartment": "compartment_70101", "id": "reaction_10722668", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722665", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684623": { "compartment": "compartment_876", "id": "reaction_10684623", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10684620", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10685930": { "compartment": "compartment_70101", "id": "reaction_10685930", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10722673": { "compartment": "compartment_70101", "id": "reaction_10722673", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722670", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10702091": { "compartment": "compartment_70101", "id": "reaction_10702091", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685921", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720498": { "compartment": "compartment_70101", "id": "reaction_10720498", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10720493", "catalyst" ] ], "additional_components": [ "DDB_G0276933" ] }, "reaction_10685010": { "compartment": "compartment_876", "id": "reaction_10685010", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685007", "catalyst" ] ], "additional_components": [ "Q54UC8", "DDB_G0281155", "Q54M69", "DDB_G0286151" ] }, "reaction_10722686": { "compartment": "compartment_70101", "id": "reaction_10722686", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720653": { "compartment": "compartment_70101", "id": "reaction_10720653", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10720650", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10684972": { "compartment": "compartment_876", "id": "reaction_10684972", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10684969", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10685927": { "compartment": "compartment_70101", "id": "reaction_10685927", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685923" ], "products": [ "species_113592", "species_10685921" ], "modifiers": [], "additional_components": [ "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10702698": { "compartment": "compartment_70101", "id": "reaction_10702698", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10702695", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10685925": { "compartment": "compartment_70101", "id": "reaction_10685925", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685921" ], "products": [ "species_10685923" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684742": { "compartment": "compartment_876", "id": "reaction_10684742", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10684739", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10715026": { "compartment": "compartment_7660", "id": "reaction_10715026", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715020" ], "products": [ "species_10680330" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10715023": { "compartment": "compartment_7660", "id": "reaction_10715023", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715006", "species_113518" ], "products": [ "species_10715020", "species_10669917" ], "modifiers": [ [ "species_10698755", "catalyst" ], [ "species_10698438", "inhibitor" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10721791": { "compartment": "compartment_70101", "id": "reaction_10721791", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10721783" ], "products": [ "species_29370", "species_10721788" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10717104": { "compartment": "compartment_70101", "id": "reaction_10717104", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680330" ], "products": [ "species_29370", "species_10717102" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10715008": { "compartment": "compartment_70101", "id": "reaction_10715008", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714984" ], "products": [ "species_10715006" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10721861": { "compartment": "compartment_70101", "id": "reaction_10721861", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_10680330" ], "products": [ "species_10721849", "species_197277" ], "modifiers": [ [ "species_10721858", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q86J21", "DDB_G0274293" ] }, "reaction_10721834": { "compartment": "compartment_70101", "id": "reaction_10721834", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689058", "species_113592" ], "products": [ "species_29370", "species_10721832" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721837": { "compartment": "compartment_70101", "id": "reaction_10721837", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715071" ], "modifiers": [ [ "species_10721832", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0281657" ] }, "reaction_10715083": { "compartment": "compartment_70101", "id": "reaction_10715083", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715073", "species_29356" ], "products": [ "species_10670153", "species_10680330" ], "modifiers": [ [ "species_10715080", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10717150": { "compartment": "compartment_70101", "id": "reaction_10717150", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717148" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10721793": { "compartment": "compartment_13231", "id": "reaction_10721793", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721783" ], "products": [ "species_10721781" ], "modifiers": [ [ "species_10677526", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10715054": { "compartment": "compartment_70101", "id": "reaction_10715054", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715043" ], "modifiers": [ [ "species_10715051", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10686632": { "compartment": "compartment_70101", "id": "reaction_10686632", "reactome": "R-DDI-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686100" ], "products": [ "species_10686630" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10686107": { "compartment": "compartment_70101", "id": "reaction_10686107", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10686094" ], "products": [ "species_29370", "species_10686046" ], "modifiers": [ [ "species_10680089", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10686113": { "compartment": "compartment_70101", "id": "reaction_10686113", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686092", "species_450523" ], "products": [ "species_10686094" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10686104": { "compartment": "compartment_70101", "id": "reaction_10686104", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10686094", "species_10685110", "species_10685181" ], "products": [ "species_10686102" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "Q54MG5", "DDB_G0285973", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251" ] }, "reaction_10686050": { "compartment": "compartment_70101", "id": "reaction_10686050", "reactome": "R-DDI-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686046" ], "products": [ "species_10686048" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10679303": { "compartment": "compartment_876", "id": "reaction_10679303", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10679300", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10679314": { "compartment": "compartment_876", "id": "reaction_10679314", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_29590", "species_70113", "species_29532", "species_29590", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10725864": { "compartment": "compartment_70101", "id": "reaction_10725864", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_10701655", "species_994146", "species_994141" ], "products": [ "species_10725862" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994146", "species_1629770", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994141" ] }, "reaction_10725860": { "compartment": "compartment_70101", "id": "reaction_10725860", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_10725858" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "species_113592", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10709720": { "compartment": "compartment_70101", "id": "reaction_10709720", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10709717", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10687988": { "compartment": "compartment_20699", "id": "reaction_10687988", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10687985", "catalyst" ] ], "additional_components": [ "DDB_G0284141" ] }, "reaction_10688162": { "compartment": "compartment_70101", "id": "reaction_10688162", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_947588", "species_29356" ], "products": [ "species_29370", "species_947594", "species_29372" ], "modifiers": [ [ "species_10688101", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500646", "species_1500581", "Q54L55", "DDB_G0286891", "Q553A4", "DDB_G0281401", "Q55E09", "DDB_G0270870", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0281401", "Q551T0", "DDB_G0281401", "Q55E61", "DDB_G0286891" ] }, "reaction_10701952": { "compartment": "compartment_70101", "id": "reaction_10701952", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10701949", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10709709": { "compartment": "compartment_70101", "id": "reaction_10709709", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10709706", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10696020": { "compartment": "compartment_161320", "id": "reaction_10696020", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10696017", "catalyst" ] ], "additional_components": [ "P54639", "DDB_G0278721", "Q559Q3", "DDB_G0291191", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10702333": { "compartment": "compartment_70101", "id": "reaction_10702333", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10702330", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10710970": { "compartment": "compartment_1660541", "id": "reaction_10710970", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710940" ], "products": [ "species_10710968" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10716374": { "compartment": "compartment_70101", "id": "reaction_10716374", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10716371", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10720699": { "compartment": "compartment_161320", "id": "reaction_10720699", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720695", "species_10720691" ], "products": [ "species_10720689", "species_10720697" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q9TVK6", "DDB_G0269158", "species_216762" ] }, "reaction_10710972": { "compartment": "compartment_1660541", "id": "reaction_10710972", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710968" ], "products": [ "species_10710966" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10720693": { "compartment": "compartment_161320", "id": "reaction_10720693", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10720689" ], "products": [ "species_10720691" ], "modifiers": [], "additional_components": [ "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185" ] }, "reaction_10720701": { "compartment": "compartment_12045", "id": "reaction_10720701", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720697" ], "products": [ "species_193384", "species_10720695" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10705109": { "compartment": "compartment_12045", "id": "reaction_10705109", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705051" ], "products": [ "species_10705071" ], "modifiers": [], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10718240": { "compartment": "compartment_876", "id": "reaction_10718240", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718230" ], "products": [ "species_10718238" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10718758": { "compartment": "compartment_70616", "id": "reaction_10718758", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_10718738" ], "products": [ "species_10718750", "species_10718744" ], "modifiers": [ [ "species_10718755", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10677317": { "compartment": "compartment_5460", "id": "reaction_10677317", "reactome": "R-DDI-163296", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677313", "species_10677301" ], "products": [ "species_10677315" ], "modifiers": [], "additional_components": [ "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260", "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260" ] }, "reaction_10677319": { "compartment": "compartment_5460", "id": "reaction_10677319", "reactome": "R-DDI-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10677299" ], "products": [ "species_10677301" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10701526": { "compartment": "compartment_70101", "id": "reaction_10701526", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701518", "species_113592" ], "products": [ "species_29370", "species_10698937" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701523": { "compartment": "compartment_70101", "id": "reaction_10701523", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701516" ], "products": [ "species_10701518", "species_29370" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701651": { "compartment": "compartment_70101", "id": "reaction_10701651", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698939", "species_10701647" ], "products": [ "species_10701649" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10702537": { "compartment": "compartment_876", "id": "reaction_10702537", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698980", "species_5620974" ], "products": [ "species_10702526" ], "modifiers": [ [ "species_10702535", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_1806180", "species_179838", "species_179856", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "species_1806180", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "species_179838", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_179856", "Q54HC6", "DDB_G0289555", "Q8T7K0", "DDB_G0275451", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10701658": { "compartment": "compartment_70101", "id": "reaction_10701658", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_29370", "species_10701655" ], "modifiers": [ [ "species_10701649", "catalyst" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10701653": { "compartment": "compartment_70101", "id": "reaction_10701653", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698937" ], "products": [ "species_10698939" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535" ] }, "reaction_10697256": { "compartment": "compartment_70101", "id": "reaction_10697256", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10683777" ], "products": [ "species_10680149" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10724239": { "compartment": "compartment_17951", "id": "reaction_10724239", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10724169" ], "products": [ "species_10724234", "species_10724236" ], "modifiers": [ [ "species_10724169", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10683109": { "compartment": "compartment_70101", "id": "reaction_10683109", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680440", "species_76577" ], "products": [ "species_10683107" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683111": { "compartment": "compartment_70101", "id": "reaction_10683111", "reactome": "R-DDI-380942", "name": "LKB1 forms a trimeric complex with STRAD and MO25", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680445", "species_10680470", "species_10680454" ], "products": [ "species_10680472" ], "modifiers": [], "additional_components": [ "DDB_G0270680", "Q551H4", "DDB_G0276577", "Q54XL6", "DDB_G0278863", "C7G028", "DDB_G0284307", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10680475": { "compartment": "compartment_70101", "id": "reaction_10680475", "reactome": "R-DDI-200421", "name": "Activation of cytosolic AMPK by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680420", "species_113592" ], "products": [ "species_29370", "species_10680440" ], "modifiers": [ [ "species_10680472", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10685835": { "compartment": "compartment_876", "id": "reaction_10685835", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_113592" ], "products": [ "species_10677585", "species_29370" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10703641": { "compartment": "compartment_17938", "id": "reaction_10703641", "reactome": "R-DDI-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10677539" ], "products": [ "species_10677541" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677561": { "compartment": "compartment_17938", "id": "reaction_10677561", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347", "species_113592" ], "products": [ "species_29370", "species_10677534" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677545", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10702256": { "compartment": "compartment_70101", "id": "reaction_10702256", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10702253", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10677608": { "compartment": "compartment_70101", "id": "reaction_10677608", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677603" ], "products": [ "species_29370", "species_10677606" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "DDB_G0286125" ] }, "reaction_10682921": { "compartment": "compartment_17938", "id": "reaction_10682921", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677545" ], "products": [ "species_29370", "species_10677539" ], "modifiers": [ [ "species_10680774", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10703164": { "compartment": "compartment_17938", "id": "reaction_10703164", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677522", "species_10677461" ], "products": [ "species_10677524" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833" ] }, "reaction_10702550": { "compartment": "compartment_70616", "id": "reaction_10702550", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10702547", "catalyst" ] ], "additional_components": [ "DDB_G0288917" ] }, "reaction_10726000": { "compartment": "compartment_7660", "id": "reaction_10726000", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10721488" ], "products": [ "species_10721490" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677587": { "compartment": "compartment_17938", "id": "reaction_10677587", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677571", "species_113592" ], "products": [ "species_29370", "species_10677575" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677585", "inhibitor" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677598": { "compartment": "compartment_70101", "id": "reaction_10677598", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673172" ], "products": [ "species_29370", "species_10677595" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "DDB_G0286125" ] }, "reaction_10702269": { "compartment": "compartment_70101", "id": "reaction_10702269", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10702266", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10703166": { "compartment": "compartment_70101", "id": "reaction_10703166", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677518", "species_10677490" ], "products": [ "species_10677520" ], "modifiers": [], "additional_components": [ "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10710352": { "compartment": "compartment_70101", "id": "reaction_10710352", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10710349", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10702261": { "compartment": "compartment_70101", "id": "reaction_10702261", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10702258", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10703160": { "compartment": "compartment_17938", "id": "reaction_10703160", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677478", "species_10677473", "species_10677488", "species_10677468", "species_10677483" ], "products": [ "species_10677490" ], "modifiers": [], "additional_components": [ "DDB_G0274833", "DDB_G0291091", "DDB_G0283567", "DDB_G0292160", "DDB_G0291948", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10703650": { "compartment": "compartment_17938", "id": "reaction_10703650", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677541" ], "products": [ "species_29370", "species_10703647" ], "modifiers": [ [ "species_10677541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "P54632", "DDB_G0269138", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677566": { "compartment": "compartment_70101", "id": "reaction_10677566", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677534" ], "products": [ "species_10673316", "species_10677532" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0268574", "DDB_G0291990" ] }, "reaction_10697038": { "compartment": "compartment_70101", "id": "reaction_10697038", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_179856" ], "products": [ "species_10697036" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179856" ] }, "reaction_10721494": { "compartment": "compartment_7660", "id": "reaction_10721494", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721482", "species_1254400" ], "products": [ "species_10721484" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677528": { "compartment": "compartment_70101", "id": "reaction_10677528", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677524", "species_10677442" ], "products": [ "species_10677526" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q550Q4", "DDB_G0277041", "species_29438", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10692083": { "compartment": "compartment_70101", "id": "reaction_10692083", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10692076" ], "products": [ "species_10692080" ], "modifiers": [ [ "species_10692076", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10722291": { "compartment": "compartment_70101", "id": "reaction_10722291", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10677522", "catalyst" ] ], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10725838": { "compartment": "compartment_70101", "id": "reaction_10725838", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677557", "species_9678687" ], "products": [ "species_10677559" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227" ] }, "reaction_10698857": { "compartment": "compartment_20699", "id": "reaction_10698857", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698851" ], "products": [ "species_10698855" ], "modifiers": [], "additional_components": [ "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168" ] }, "reaction_10723074": { "compartment": "compartment_7660", "id": "reaction_10723074", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10723069" ], "products": [ "species_113582", "species_10723071" ], "modifiers": [ [ "species_10723069", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10703162": { "compartment": "compartment_70101", "id": "reaction_10703162", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677503", "species_10677516" ], "products": [ "species_10677518" ], "modifiers": [], "additional_components": [ "species_29438", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701" ] }, "reaction_10677615": { "compartment": "compartment_70101", "id": "reaction_10677615", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673321" ], "products": [ "species_29370", "species_10677613" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "DDB_G0286125" ] }, "reaction_10677444": { "compartment": "compartment_17938", "id": "reaction_10677444", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10677440" ], "products": [ "species_10677442", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q550Q4", "DDB_G0277041", "Q550Q4", "DDB_G0277041", "species_29438" ] }, "reaction_10692085": { "compartment": "compartment_70101", "id": "reaction_10692085", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692080" ], "products": [ "species_10670153", "species_10692072" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689651": { "compartment": "compartment_70101", "id": "reaction_10689651", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689645", "species_10689647" ], "products": [ "species_10689649" ], "modifiers": [], "additional_components": [ "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q9GPS0", "DDB_G0269178", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "P34144", "DDB_G0277869", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10689421": { "compartment": "compartment_70101", "id": "reaction_10689421", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689367" ], "products": [ "species_10689369" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10689432": { "compartment": "compartment_7660", "id": "reaction_10689432", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689428", "species_10689425" ], "products": [ "species_10689430" ], "modifiers": [], "additional_components": [ "DDB_G0267402", "DDB_G0283023", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402" ] }, "reaction_10697214": { "compartment": "compartment_70101", "id": "reaction_10697214", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689440": { "compartment": "compartment_70101", "id": "reaction_10689440", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689423": { "compartment": "compartment_70101", "id": "reaction_10689423", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689374" ], "products": [ "species_10689376" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10689514": { "compartment": "compartment_5460", "id": "reaction_10689514", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10689511", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10684256": { "compartment": "compartment_984", "id": "reaction_10684256", "reactome": "R-DDI-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676753", "species_114570" ], "products": [ "species_10676755" ], "modifiers": [], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335", "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10689443": { "compartment": "compartment_70101", "id": "reaction_10689443", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689499": { "compartment": "compartment_70101", "id": "reaction_10689499", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687040", "species_10689495" ], "products": [ "species_10689497" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920" ] }, "reaction_10687042": { "compartment": "compartment_70101", "id": "reaction_10687042", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687038", "species_10687033" ], "products": [ "species_10687040" ], "modifiers": [], "additional_components": [ "DDB_G0267374", "DDB_G0272104", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10680829": { "compartment": "compartment_70101", "id": "reaction_10680829", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_202277" ], "products": [ "species_10680827" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_202247", "species_179838", "species_202247", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10724241": { "compartment": "compartment_17947", "id": "reaction_10724241", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722369", "species_10724179" ], "products": [ "species_10724181" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724072": { "compartment": "compartment_70101", "id": "reaction_10724072", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724057", "species_10724068" ], "products": [ "species_10724070" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724186": { "compartment": "compartment_17947", "id": "reaction_10724186", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724181" ], "products": [ "species_10690046", "species_10724183" ], "modifiers": [ [ "species_10724181", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724348": { "compartment": "compartment_17947", "id": "reaction_10724348", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724328" ], "products": [ "species_10683511", "species_10724346", "species_10683495" ], "modifiers": [], "additional_components": [ "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "DDB_G0281213" ] }, "reaction_10724616": { "compartment": "compartment_70101", "id": "reaction_10724616", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724612" ], "products": [ "species_10724614" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724509": { "compartment": "compartment_70101", "id": "reaction_10724509", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724505" ], "products": [ "species_10724507" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724173": { "compartment": "compartment_17947", "id": "reaction_10724173", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724151" ], "products": [ "species_10722365", "species_10724171" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724195": { "compartment": "compartment_70101", "id": "reaction_10724195", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724192", "species_29356" ], "products": [ "species_10670153", "species_10724145", "species_10717909" ], "modifiers": [ [ "species_10724192", "catalyst" ] ], "additional_components": [ "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286033", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724232": { "compartment": "compartment_17947", "id": "reaction_10724232", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724222" ], "products": [ "species_10724179", "species_10724230" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "O96759", "DDB_G0286183", "Q54N40", "DDB_G0285523", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724352": { "compartment": "compartment_70101", "id": "reaction_10724352", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683511", "species_10724324" ], "products": [ "species_10724326" ], "modifiers": [], "additional_components": [ "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10724218": { "compartment": "compartment_70101", "id": "reaction_10724218", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724190", "species_10717909" ], "products": [ "species_10724192" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724175": { "compartment": "compartment_17947", "id": "reaction_10724175", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724147", "species_10724149" ], "products": [ "species_10724151" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724350": { "compartment": "compartment_17947", "id": "reaction_10724350", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683495", "species_10724326" ], "products": [ "species_10724328" ], "modifiers": [], "additional_components": [ "DDB_G0281213", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10701703": { "compartment": "compartment_70101", "id": "reaction_10701703", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701694" ], "products": [ "species_10701701" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10702088": { "compartment": "compartment_70101", "id": "reaction_10702088", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10702085", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10702104": { "compartment": "compartment_70101", "id": "reaction_10702104", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702101", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10702099": { "compartment": "compartment_70101", "id": "reaction_10702099", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702096", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10721599": { "compartment": "compartment_70101", "id": "reaction_10721599", "reactome": "R-DDI-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10721596", "catalyst" ] ], "additional_components": [ "species_188972", "species_209818", "species_188972", "species_209818", "Q54PM1", "DDB_G0284461" ] }, "reaction_10701711": { "compartment": "compartment_70101", "id": "reaction_10701711", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701707" ], "products": [ "species_10701709" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10675618": { "compartment": "compartment_7660", "id": "reaction_10675618", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10675608" ], "products": [ "species_10675615", "species_111349" ], "modifiers": [ [ "species_10675608", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675632": { "compartment": "compartment_7660", "id": "reaction_10675632", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675625", "species_77087" ], "products": [ "species_10673970", "species_10672159", "species_10675598", "species_10675629", "species_77502" ], "modifiers": [ [ "species_10675625", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0287661", "Q54Y13", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675623": { "compartment": "compartment_7660", "id": "reaction_10675623", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675615" ], "products": [ "species_10675620" ], "modifiers": [ [ "species_10675615", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675606": { "compartment": "compartment_7660", "id": "reaction_10675606", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_10675600", "species_29428" ], "products": [ "species_10675604" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675634": { "compartment": "compartment_7660", "id": "reaction_10675634", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672073", "species_10672078" ], "products": [ "species_10672080" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10675611": { "compartment": "compartment_7660", "id": "reaction_10675611", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675604" ], "products": [ "species_113550", "species_10675608" ], "modifiers": [ [ "species_10675604", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675627": { "compartment": "compartment_7660", "id": "reaction_10675627", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675620" ], "products": [ "species_10675625" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675636": { "compartment": "compartment_7660", "id": "reaction_10675636", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672080", "species_10672159" ], "products": [ "species_10672161" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10711945": { "compartment": "compartment_7660", "id": "reaction_10711945", "reactome": "R-DDI-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10711942" ], "products": [ "species_2485002", "species_10704963" ], "modifiers": [ [ "species_10711942", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10722637": { "compartment": "compartment_7660", "id": "reaction_10722637", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10698776" ], "products": [ "species_10698778" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10698781": { "compartment": "compartment_7660", "id": "reaction_10698781", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10698769" ], "products": [ "species_159939", "species_10698771" ], "modifiers": [ [ "species_10698778", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10704968": { "compartment": "compartment_7660", "id": "reaction_10704968", "reactome": "R-DDI-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10704963" ], "products": [ "species_113582", "species_10704965", "species_10682355" ], "modifiers": [ [ "species_10704963", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10718247": { "compartment": "compartment_984", "id": "reaction_10718247", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10718244", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10712967": { "compartment": "compartment_6800173", "id": "reaction_10712967", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712871" ], "products": [ "species_10712965" ], "modifiers": [], "additional_components": [ "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q65YR8", "DDB_G0291834", "Q54V78", "DDB_G0349530", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q65YR7", "DDB_G0280439", "Q54RQ2", "DDB_G0282991", "Q54Q34", "DDB_G0349530", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490", "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q54V78", "DDB_G0349530", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q54RQ2", "DDB_G0282991", "Q65YR7", "DDB_G0280439", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490" ] }, "reaction_10711257": { "compartment": "compartment_21994", "id": "reaction_10711257", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711254", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10714086": { "compartment": "compartment_1470028", "id": "reaction_10714086", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713952" ], "products": [ "species_10714084" ], "modifiers": [], "additional_components": [ "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179", "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179" ] }, "reaction_10714758": { "compartment": "compartment_984", "id": "reaction_10714758", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714736" ], "products": [ "species_10714756" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10712473": { "compartment": "compartment_6798757", "id": "reaction_10712473", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712371" ], "products": [ "species_10712471" ], "modifiers": [], "additional_components": [ "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791" ] }, "reaction_10686832": { "compartment": "compartment_70101", "id": "reaction_10686832", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677800" ], "products": [ "species_10677804" ], "modifiers": [], "additional_components": [ "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10686854": { "compartment": "compartment_70101", "id": "reaction_10686854", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677816" ], "products": [ "species_10677818" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10711262": { "compartment": "compartment_21994", "id": "reaction_10711262", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10711252" ], "products": [ "species_10711254" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10721333": { "compartment": "compartment_1222282", "id": "reaction_10721333", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677802": { "compartment": "compartment_70101", "id": "reaction_10677802", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677798", "species_622271" ], "products": [ "species_10677800" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10713614": { "compartment": "compartment_1462052", "id": "reaction_10713614", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713428" ], "products": [ "species_10713612" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10711260": { "compartment": "compartment_1222282", "id": "reaction_10711260", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677848": { "compartment": "compartment_70101", "id": "reaction_10677848", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10677814" ], "products": [ "species_10677816" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10713716": { "compartment": "compartment_6799371", "id": "reaction_10713716", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713682" ], "products": [ "species_10713714" ], "modifiers": [], "additional_components": [ "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54V78", "DDB_G0349530", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q55BA2", "DDB_G0271242", "Q6UK63", "DDB_G0287855", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54B14", "DDB_G0293986", "Q556T3", "DDB_G0273107", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490", "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q54V78", "DDB_G0349530", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q6UK63", "DDB_G0287855", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490" ] }, "reaction_10714477": { "compartment": "compartment_6800424", "id": "reaction_10714477", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714461" ], "products": [ "species_10714475" ], "modifiers": [], "additional_components": [ "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735", "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735" ] }, "reaction_10689989": { "compartment": "compartment_1222693", "id": "reaction_10689989", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10689986", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10725834": { "compartment": "compartment_70101", "id": "reaction_10725834", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725772", "species_10677814" ], "products": [ "species_10725832" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55E90", "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10714292": { "compartment": "compartment_6799351", "id": "reaction_10714292", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714270" ], "products": [ "species_10714290" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013", "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013" ] }, "reaction_10677846": { "compartment": "compartment_70101", "id": "reaction_10677846", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677842", "species_10677820" ], "products": [ "species_10677844" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54HC6", "DDB_G0289555", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54XX5", "DDB_G0278535" ] }, "reaction_10712733": { "compartment": "compartment_876", "id": "reaction_10712733", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712651" ], "products": [ "species_10712731" ], "modifiers": [], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735", "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735" ] }, "reaction_10713133": { "compartment": "compartment_6799713", "id": "reaction_10713133", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713083" ], "products": [ "species_10713131" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "Q54F59", "DDB_G0291091", "P03967", "DDB_G0292996", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q86A88", "DDB_G0274815", "Q54YE6", "DDB_G0284903", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "Q86A88", "DDB_G0274815", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735" ] }, "reaction_10686034": { "compartment": "compartment_70101", "id": "reaction_10686034", "reactome": "R-DDI-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686030" ], "products": [ "species_10686032" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686715": { "compartment": "compartment_7660", "id": "reaction_10686715", "reactome": "R-DDI-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10686131" ], "products": [ "species_10686713" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686719": { "compartment": "compartment_7660", "id": "reaction_10686719", "reactome": "R-DDI-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686123", "species_517622" ], "products": [ "species_10686717" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686111": { "compartment": "compartment_7660", "id": "reaction_10686111", "reactome": "R-DDI-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450613", "species_10672405" ], "products": [ "species_10686109" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686040": { "compartment": "compartment_70101", "id": "reaction_10686040", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686021", "species_10686036", "species_450597" ], "products": [ "species_10686038" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686059": { "compartment": "compartment_70101", "id": "reaction_10686059", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10685110", "species_10685181", "species_10686038" ], "products": [ "species_10686057" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10699437": { "compartment": "compartment_70101", "id": "reaction_10699437", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699426" ], "products": [ "species_29370", "species_10699429" ], "modifiers": [ [ "species_10699434", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10699539": { "compartment": "compartment_70101", "id": "reaction_10699539", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699537" ], "products": [ "species_10699479", "species_10699426", "species_10682231" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10699547": { "compartment": "compartment_70101", "id": "reaction_10699547", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699426" ], "products": [ "species_10699491" ], "modifiers": [ [ "species_10676967", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10699508": { "compartment": "compartment_7660", "id": "reaction_10699508", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684694", "species_10699504" ], "products": [ "species_10699506" ], "modifiers": [], "additional_components": [ "DDB_G0289967", "DDB_G0274577", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10700882": { "compartment": "compartment_70101", "id": "reaction_10700882", "reactome": "R-DDI-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700878", "species_10674717" ], "products": [ "species_10700880" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54UC1", "DDB_G0281165" ] }, "reaction_10701046": { "compartment": "compartment_7660", "id": "reaction_10701046", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701044" ], "products": [ "species_10701042", "species_10701017", "species_10701036" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10701966": { "compartment": "compartment_70101", "id": "reaction_10701966", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10701961" ], "products": [ "species_10699479", "species_10699426", "species_10682231", "species_10701963" ], "modifiers": [ [ "species_10701961", "catalyst" ] ], "additional_components": [ "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042", "P90532", "DDB_G0288065", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699522": { "compartment": "compartment_7660", "id": "reaction_10699522", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10699510" ], "products": [ "species_113582", "species_10699504" ], "modifiers": [ [ "species_10699519", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "Q553E9", "DDB_G0275845", "Q54ER4", "DDB_G0291380" ] }, "reaction_10701019": { "compartment": "compartment_7660", "id": "reaction_10701019", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701017" ], "products": [ "species_10699495" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699497": { "compartment": "compartment_70101", "id": "reaction_10699497", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699491" ], "products": [ "species_10699495" ], "modifiers": [ [ "species_10674717", "inhibitor" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P54632", "DDB_G0269138" ] }, "reaction_10675699": { "compartment": "compartment_7660", "id": "reaction_10675699", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675693", "species_10672837" ], "products": [ "species_10675697" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q54LG7", "DDB_G0286645", "Q54XS9", "DDB_G0278769", "Q54V94", "DDB_G0280529", "Q54LG7", "DDB_G0286645", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54XS9", "DDB_G0278769", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q54V94", "DDB_G0280529", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10675695": { "compartment": "compartment_7660", "id": "reaction_10675695", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672816", "species_10675691" ], "products": [ "species_10675693" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q54TS6", "DDB_G0281585", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10697903": { "compartment": "compartment_70101", "id": "reaction_10697903", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697893", "species_2534019" ], "products": [ "species_76194", "species_10674265" ], "modifiers": [ [ "species_10697898", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "DDB_G0275863" ] }, "reaction_10674540": { "compartment": "compartment_2514888", "id": "reaction_10674540", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10674512", "catalyst" ], [ "species_10674532", "catalyst" ], [ "species_10674534", "catalyst" ], [ "species_10674536", "inhibitor" ], [ "species_10674530", "inhibitor" ], [ "species_10674538", "inhibitor" ] ], "additional_components": [ "Q553Y7", "DDB_G0275009", "Q03101", "DDB_G0274569", "DDB_G0275931", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10698058": { "compartment": "compartment_70101", "id": "reaction_10698058", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10674518" ], "products": [ "species_10674530" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10697932": { "compartment": "compartment_70101", "id": "reaction_10697932", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697913" ], "products": [ "species_10697893", "species_174390" ], "modifiers": [ [ "species_10697929", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10685127": { "compartment": "compartment_70101", "id": "reaction_10685127", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685092", "species_429974" ], "products": [ "species_10685094" ], "modifiers": [], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453" ] }, "reaction_10685125": { "compartment": "compartment_70101", "id": "reaction_10685125", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685094", "species_29356" ], "products": [ "species_10685096", "species_430004" ], "modifiers": [ [ "species_10685122", "catalyst" ] ], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q54R87", "DDB_G0283315", "Q54KM1", "DDB_G0287243", "Q54J96", "DDB_G0288241", "Q54E49", "DDB_G0291804" ] }, "reaction_10683236": { "compartment": "compartment_12045", "id": "reaction_10683236", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683208", "species_113592" ], "products": [ "species_29370", "species_10683233" ], "modifiers": [ [ "species_10683208", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10683169": { "compartment": "compartment_12045", "id": "reaction_10683169", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683158" ], "products": [ "species_10683167" ], "modifiers": [], "additional_components": [ "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10683136": { "compartment": "compartment_70101", "id": "reaction_10683136", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683128" ], "products": [ "species_10683134" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683288": { "compartment": "compartment_12045", "id": "reaction_10683288", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683284" ], "products": [ "species_10683258" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683246": { "compartment": "compartment_70101", "id": "reaction_10683246", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_113592" ], "products": [ "species_29370", "species_10683243" ], "modifiers": [ [ "species_10683167", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10684272": { "compartment": "compartment_20699", "id": "reaction_10684272", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683264" ], "products": [ "species_10684264", "species_10683128" ], "modifiers": [ [ "species_10684269", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10683278": { "compartment": "compartment_20699", "id": "reaction_10683278", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683258" ], "products": [ "species_10683264", "species_10683270" ], "modifiers": [ [ "species_10683275", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0270252" ] }, "reaction_10683238": { "compartment": "compartment_12045", "id": "reaction_10683238", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683206" ], "products": [ "species_10683208" ], "modifiers": [], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10682271": { "compartment": "compartment_984", "id": "reaction_10682271", "reactome": "R-DDI-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10682267" ], "products": [ "species_10682269" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657", "species_265479", "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657" ] }, "reaction_10687765": { "compartment": "compartment_70101", "id": "reaction_10687765", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687761", "species_10687744" ], "products": [ "species_10687763", "species_10687742" ], "modifiers": [], "additional_components": [ "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55DV8", "DDB_G0269510", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DV8", "DDB_G0269510", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295" ] }, "reaction_10718224": { "compartment": "compartment_262783", "id": "reaction_10718224", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718207", "species_10718220", "species_10718215" ], "products": [ "species_10718222" ], "modifiers": [], "additional_components": [ "DDB_G0269238", "DDB_G0269130", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "P36412", "DDB_G0269238", "O96904", "DDB_G0269130", "Q54R95", "DDB_G0283337" ] }, "reaction_10718103": { "compartment": "compartment_17938", "id": "reaction_10718103", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718076", "species_29356" ], "products": [ "species_10718078", "species_29372" ], "modifiers": [ [ "species_10718076", "catalyst" ], [ "species_10718101", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "CHEBI:15996", "species_29420", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "CHEBI:15996", "Q54WP7", "DDB_G0295717", "Q75JG4", "DDB_G0276119", "C7G032", "DDB_G0295717", "Q553Q2", "DDB_G0295717" ] }, "reaction_10718045": { "compartment": "compartment_24339", "id": "reaction_10718045", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718015" ], "products": [ "species_10718017", "species_29372" ], "modifiers": [ [ "species_10718015", "catalyst" ], [ "species_10718043", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "species_29420", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q55F14", "DDB_G0269052", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421" ] }, "reaction_10718182": { "compartment": "compartment_5683628", "id": "reaction_10718182", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718176", "species_10718178" ], "products": [ "species_10718180" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q54IE1", "DDB_G0288811", "Q86CR8", "DDB_G0286191" ] }, "reaction_10718193": { "compartment": "compartment_437051", "id": "reaction_10718193", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718188", "species_29356" ], "products": [ "species_29372", "species_10718190" ], "modifiers": [ [ "species_10718188", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "CHEBI:15996", "Q54DA7", "DDB_G0292406", "species_111349", "Q54DA7", "DDB_G0292406", "CHEBI:15996" ] }, "reaction_10718058": { "compartment": "compartment_19363", "id": "reaction_10718058", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718048", "species_10718054" ], "products": [ "species_10718056" ], "modifiers": [], "additional_components": [ "DDB_G0282977", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q54RR0", "DDB_G0282977" ] }, "reaction_10718135": { "compartment": "compartment_20699", "id": "reaction_10718135", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718131", "species_10716961" ], "products": [ "species_10718133" ], "modifiers": [], "additional_components": [ "Q54H32", "DDB_G0289735", "Q54KE5", "DDB_G0289735", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "species_29438", "Q54H32", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "Q54KE5", "DDB_G0289735", "species_29438", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735" ] }, "reaction_10687717": { "compartment": "compartment_74700", "id": "reaction_10687717", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687496", "species_113592" ], "products": [ "species_29370", "species_10687276", "species_10687698", "species_10687290", "species_10687285", "species_29372", "species_10687266", "species_10687271" ], "modifiers": [ [ "species_10687714", "catalyst" ] ], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "DDB_G0275573", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "species_179838", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0287993", "DDB_G0287021", "DDB_G0290087", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q54PT2", "DDB_G0284347", "Q55B11", "DDB_G0271488" ] }, "reaction_10687767": { "compartment": "compartment_70101", "id": "reaction_10687767", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687763", "species_10687292" ], "products": [ "species_10687496", "species_10687761" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708" ] }, "reaction_10718204": { "compartment": "compartment_5683628", "id": "reaction_10718204", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718199" ], "products": [ "species_10718201", "species_29372" ], "modifiers": [ [ "species_10718199", "catalyst" ], [ "species_10718178", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "species_29420", "O76173", "DDB_G0269174", "O76173", "DDB_G0269174", "species_29438", "DDB_G0288811" ] }, "reaction_10718173": { "compartment": "compartment_17938", "id": "reaction_10718173", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718163", "species_29356" ], "products": [ "species_10718165", "species_29372" ], "modifiers": [ [ "species_10718163", "catalyst" ], [ "species_10718171", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_111349", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "DDB_G0288811" ] }, "reaction_10722615": { "compartment": "compartment_70101", "id": "reaction_10722615", "reactome": "R-DDI-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674492" ], "products": [ "species_10674488", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q54YX3", "DDB_G0278031", "DDB_G0278031" ] }, "reaction_10697511": { "compartment": "compartment_70101", "id": "reaction_10697511", "reactome": "R-DDI-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674488", "species_30927" ], "products": [ "species_10674490" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_30927", "Q54YX3", "DDB_G0278031" ] }, "reaction_10709524": { "compartment": "compartment_70101", "id": "reaction_10709524", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10709517", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] }, "reaction_10709660": { "compartment": "compartment_70101", "id": "reaction_10709660", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10709521" ], "products": [ "species_10709651" ], "modifiers": [ [ "species_10709657", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0279159", "DDB_G0279159", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10709669": { "compartment": "compartment_70101", "id": "reaction_10709669", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10678831" ], "products": [ "species_10709667" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "DDB_G0267384", "Q86KD1", "DDB_G0274167", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10709519": { "compartment": "compartment_70101", "id": "reaction_10709519", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10709515" ], "products": [ "species_10709517" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10687777": { "compartment": "compartment_74700", "id": "reaction_10687777", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10687774", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10687769": { "compartment": "compartment_74700", "id": "reaction_10687769", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] } }, "collapsed_reaction_dictionary": { "reaction_10677351": { "compartment": "compartment_7660", "id": "reaction_10677351", "reactome": "R-DDI-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674916" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10677345": { "compartment": "compartment_7660", "id": "reaction_10677345", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674902" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10677349": { "compartment": "compartment_7660", "id": "reaction_10677349", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10677347" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10696321": { "compartment": "compartment_876", "id": "reaction_10696321", "reactome": "R-DDI-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696053" ], "products": [ "species_10696319", "species_10696293" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696409": { "compartment": "compartment_984", "id": "reaction_10696409", "reactome": "R-DDI-2168038", "name": "Collagen type XV restin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696351" ], "products": [ "species_10696407", "species_10696403" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697814": { "compartment": "compartment_984", "id": "reaction_10697814", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695841" ], "products": [ "species_10697743" ], "modifiers": [ [ "species_10697811", "catalyst" ] ], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696557": { "compartment": "compartment_984", "id": "reaction_10696557", "reactome": "R-DDI-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696458" ], "products": [ "species_10696464", "species_10696490" ], "modifiers": [ [ "species_10696554", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696587": { "compartment": "compartment_984", "id": "reaction_10696587", "reactome": "R-DDI-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696585" ], "products": [], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585" ] }, "reaction_10697697": { "compartment": "compartment_984", "id": "reaction_10697697", "reactome": "R-DDI-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696490" ], "products": [], "modifiers": [ [ "species_10697694", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10700000": { "compartment": "compartment_984", "id": "reaction_10700000", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692323" ], "products": [ "species_10699995", "species_10699997" ], "modifiers": [ [ "species_10696532", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10677776": { "compartment": "compartment_70101", "id": "reaction_10677776", "reactome": "R-DDI-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677695" ], "products": [ "species_10677763", "species_29370" ], "modifiers": [ [ "species_10677773", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54HS0", "DDB_G0289277" ] }, "reaction_10721800": { "compartment": "compartment_70101", "id": "reaction_10721800", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685829" ], "products": [ "species_10680841", "species_10721798" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10710974": { "compartment": "compartment_70101", "id": "reaction_10710974", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689687" ], "products": [ "species_10689719" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722948": { "compartment": "compartment_70101", "id": "reaction_10722948", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722934" ], "products": [ "species_10722946" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711315": { "compartment": "compartment_17957", "id": "reaction_10711315", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10711313" ], "modifiers": [ [ "species_10689719", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721951": { "compartment": "compartment_70101", "id": "reaction_10721951", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721937" ], "products": [ "species_10721949" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711217": { "compartment": "compartment_70101", "id": "reaction_10711217", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711213" ], "products": [ "species_10711215" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689919": { "compartment": "compartment_70101", "id": "reaction_10689919", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689914", "species_10689903" ], "products": [ "species_10689901", "species_10687967", "species_111294", "species_76577", "species_10689916" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54FR5", "DDB_G0290629", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10722886": { "compartment": "compartment_70101", "id": "reaction_10722886", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722870" ], "products": [ "species_10722884" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689924": { "compartment": "compartment_70101", "id": "reaction_10689924", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689905", "species_10687967" ], "products": [ "species_10689897", "species_10687972" ], "modifiers": [ [ "species_10687967", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10723442": { "compartment": "compartment_984", "id": "reaction_10723442", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10682859" ], "products": [ "species_10723440" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10722811": { "compartment": "compartment_70101", "id": "reaction_10722811", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722797" ], "products": [ "species_10722809" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689723": { "compartment": "compartment_70101", "id": "reaction_10689723", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689691" ], "products": [ "species_10689721" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10687013": { "compartment": "compartment_7660", "id": "reaction_10687013", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687009", "species_10686997", "species_10686965" ], "products": [ "species_10687011" ], "modifiers": [], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q8N0B4", "DDB_G0286189", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q555X5", "DDB_G0274743", "O00910", "DDB_G0281381", "Q55FZ7", "DDB_G0267886", "Q54BD4", "DDB_G0293532", "Q54V57", "DDB_G0280603" ] }, "reaction_10721796": { "compartment": "compartment_70101", "id": "reaction_10721796", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685818", "species_10685820" ], "products": [ "species_10685822" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722845": { "compartment": "compartment_70101", "id": "reaction_10722845", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722809" ], "products": [ "species_10722843" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685968": { "compartment": "compartment_70101", "id": "reaction_10685968", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685956", "species_113592" ], "products": [ "species_29370", "species_10677773" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10726042": { "compartment": "compartment_70101", "id": "reaction_10726042", "reactome": "R-DDI-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726002", "species_10687129" ], "products": [ "species_10726040" ], "modifiers": [], "additional_components": [ "DDB_G0273149", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q557F4", "DDB_G0273149" ] }, "reaction_10710976": { "compartment": "compartment_70101", "id": "reaction_10710976", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683" ], "products": [ "species_10689687" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721987": { "compartment": "compartment_70101", "id": "reaction_10721987", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721983" ], "products": [ "species_10721985" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721981": { "compartment": "compartment_70101", "id": "reaction_10721981", "reactome": "R-DDI-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721977" ], "products": [ "species_10721979" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685976": { "compartment": "compartment_70101", "id": "reaction_10685976", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685974" ], "products": [ "species_29370", "species_10685942" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10689693": { "compartment": "compartment_70101", "id": "reaction_10689693", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689685" ], "products": [ "species_10689691" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685950": { "compartment": "compartment_70101", "id": "reaction_10685950", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685942" ], "products": [ "species_10685948" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10722868": { "compartment": "compartment_70101", "id": "reaction_10722868", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722797" ], "products": [ "species_10722866" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722872": { "compartment": "compartment_70101", "id": "reaction_10722872", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722860" ], "products": [ "species_10722870" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721989": { "compartment": "compartment_70101", "id": "reaction_10721989", "reactome": "R-DDI-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689689" ], "products": [ "species_10689717" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686004": { "compartment": "compartment_70101", "id": "reaction_10686004", "reactome": "R-DDI-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677763" ], "products": [ "species_10686002" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10718623": { "compartment": "compartment_7660", "id": "reaction_10718623", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718594", "species_10718601" ], "products": [ "species_10718621" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0267402", "Q54MP8", "DDB_G0285837", "O15819", "DDB_G0267402" ] }, "reaction_10685884": { "compartment": "compartment_984", "id": "reaction_10685884", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10685874" ], "products": [ "species_10685876" ], "modifiers": [ [ "species_10685882", "inhibitor" ] ], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231", "Q54YE6", "DDB_G0284903", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q54QC8", "DDB_G0283937", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10693415": { "compartment": "compartment_70101", "id": "reaction_10693415", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693390", "species_10689903" ], "products": [ "species_10693392" ], "modifiers": [], "additional_components": [ "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979" ] }, "reaction_10685832": { "compartment": "compartment_70101", "id": "reaction_10685832", "reactome": "R-DDI-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685822" ], "products": [ "species_10685829" ], "modifiers": [ [ "species_10685822", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722864": { "compartment": "compartment_70101", "id": "reaction_10722864", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722860" ], "products": [ "species_10722862" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10693413": { "compartment": "compartment_70101", "id": "reaction_10693413", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693409", "species_10693392" ], "products": [ "species_10693411", "species_10693407" ], "modifiers": [], "additional_components": [ "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406" ] }, "reaction_10686967": { "compartment": "compartment_13231", "id": "reaction_10686967", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686953" ], "products": [ "species_10686965" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722952": { "compartment": "compartment_70101", "id": "reaction_10722952", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722932" ], "products": [ "species_10722934" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685932": { "compartment": "compartment_70101", "id": "reaction_10685932", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685816", "species_10685814" ], "products": [ "species_10685818" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10680392": { "compartment": "compartment_7660", "id": "reaction_10680392", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10680389", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10718598": { "compartment": "compartment_7660", "id": "reaction_10718598", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698721", "species_10718594" ], "products": [ "species_10718596" ], "modifiers": [], "additional_components": [ "DDB_G0285205", "DDB_G0285837", "Q54MP8", "DDB_G0285837", "Q55C32", "DDB_G0285205" ] }, "reaction_10689908": { "compartment": "compartment_70101", "id": "reaction_10689908", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687972", "species_10687957", "species_113592" ], "products": [ "species_10689905", "species_111294", "species_76577" ], "modifiers": [ [ "species_10687972", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10721991": { "compartment": "compartment_70101", "id": "reaction_10721991", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721935" ], "products": [ "species_10721937" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686171": { "compartment": "compartment_70101", "id": "reaction_10686171", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686160" ], "products": [ "species_10686168" ], "modifiers": [ [ "species_10686160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10722999": { "compartment": "compartment_70101", "id": "reaction_10722999", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683071", "species_113592" ], "products": [ "species_10722807", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711221": { "compartment": "compartment_70101", "id": "reaction_10711221", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711215" ], "products": [ "species_10711219" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721993": { "compartment": "compartment_70101", "id": "reaction_10721993", "reactome": "R-DDI-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10721935" ], "products": [ "species_10721983" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722966": { "compartment": "compartment_70101", "id": "reaction_10722966", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722920" ], "products": [ "species_10722964" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711033": { "compartment": "compartment_70101", "id": "reaction_10711033", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711027" ], "products": [ "species_10711031" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721995": { "compartment": "compartment_70101", "id": "reaction_10721995", "reactome": "R-DDI-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10687127" ], "products": [ "species_10689689" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722989": { "compartment": "compartment_984", "id": "reaction_10722989", "reactome": "R-DDI-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10689912": { "compartment": "compartment_70101", "id": "reaction_10689912", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687957", "species_10688804" ], "products": [ "species_10689910" ], "modifiers": [], "additional_components": [ "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063", "Q54CI1", "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10689954": { "compartment": "compartment_70101", "id": "reaction_10689954", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689950", "species_10689903" ], "products": [ "species_10689901", "species_10689952", "species_10687967", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10693385": { "compartment": "compartment_70101", "id": "reaction_10693385", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689952" ], "products": [ "species_141681", "species_10689950" ], "modifiers": [ [ "species_10693382", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q54H96", "DDB_G0289611" ] }, "reaction_10711065": { "compartment": "compartment_70101", "id": "reaction_10711065", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711031" ], "products": [ "species_10711063" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10723438": { "compartment": "compartment_984", "id": "reaction_10723438", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10723434" ], "products": [ "species_10723436" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10689921": { "compartment": "compartment_70101", "id": "reaction_10689921", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689901", "species_10689897" ], "products": [ "species_10689903" ], "modifiers": [], "additional_components": [ "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10681044": { "compartment": "compartment_7660", "id": "reaction_10681044", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10681041", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54CK7", "DDB_G0292880", "Q55CS8", "DDB_G0270688", "Q55CS7", "DDB_G0269918", "Q8T813", "DDB_G0292880", "Q54N84", "DDB_G0292880", "Q55BI8", "DDB_G0292880", "Q556Y8", "DDB_G0292880" ] }, "reaction_10722922": { "compartment": "compartment_70101", "id": "reaction_10722922", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721965" ], "products": [ "species_10722920" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10700120": { "compartment": "compartment_70101", "id": "reaction_10700120", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10700111" ], "products": [ "species_29370", "species_10700117" ], "modifiers": [ [ "species_10700111", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10700113": { "compartment": "compartment_876", "id": "reaction_10700113", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681384", "species_10683631" ], "products": [ "species_10700111" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10680511": { "compartment": "compartment_70101", "id": "reaction_10680511", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674849", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10686784": { "compartment": "compartment_70101", "id": "reaction_10686784", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10686781", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10686779": { "compartment": "compartment_70101", "id": "reaction_10686779", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548794", "species_29508" ], "products": [ "species_76194", "species_113528", "species_548829" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10680602": { "compartment": "compartment_70101", "id": "reaction_10680602", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10680599", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10718402": { "compartment": "compartment_5460", "id": "reaction_10718402", "reactome": "R-DDI-8862152", "name": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8862377", "species_113600", "species_113529" ], "products": [ "species_113563", "species_8862371" ], "modifiers": [ [ "species_10718399", "catalyst" ] ], "additional_components": [ "Q75JT8", "DDB_G0272154", "Q55E82", "DDB_G0269356" ] }, "reaction_10710291": { "compartment": "compartment_70101", "id": "reaction_10710291", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_5695985", "species_113592" ], "products": [ "species_5695971", "species_111294", "species_76577" ], "modifiers": [ [ "species_10710288", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10686794": { "compartment": "compartment_70101", "id": "reaction_10686794", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10686789", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10674838": { "compartment": "compartment_70101", "id": "reaction_10674838", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10674835", "catalyst" ] ], "additional_components": [ "Q54YA0", "DDB_G0278345" ] }, "reaction_10677353": { "compartment": "compartment_70101", "id": "reaction_10677353", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674902" ], "products": [ "species_10674904" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10709494": { "compartment": "compartment_161320", "id": "reaction_10709494", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10709491", "catalyst" ] ], "additional_components": [ "species_6785219", "species_400452", "DDB_G0288807" ] }, "reaction_10710299": { "compartment": "compartment_5460", "id": "reaction_10710299", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_5696003", "species_159450" ], "modifiers": [ [ "species_10710296", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10686768": { "compartment": "compartment_70101", "id": "reaction_10686768", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10674907": { "compartment": "compartment_70101", "id": "reaction_10674907", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10674904", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10686777": { "compartment": "compartment_70101", "id": "reaction_10686777", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10709097": { "compartment": "compartment_161320", "id": "reaction_10709097", "reactome": "R-DDI-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10709094", "catalyst" ] ], "additional_components": [ "Q54N35", "DDB_G0288807", "Q54IE5", "DDB_G0288807" ] }, "reaction_10722585": { "compartment": "compartment_5460", "id": "reaction_10722585", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10722582", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10704723": { "compartment": "compartment_12045", "id": "reaction_10704723", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10704720", "catalyst" ] ], "additional_components": [ "Q54YR9", "DDB_G0278113", "Q54Y54", "DDB_G0278683" ] }, "reaction_10723486": { "compartment": "compartment_70101", "id": "reaction_10723486", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_9014643", "species_29356" ], "modifiers": [ [ "species_10723483", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10723494": { "compartment": "compartment_70101", "id": "reaction_10723494", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10723491", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10724544": { "compartment": "compartment_74700", "id": "reaction_10724544", "reactome": "R-DDI-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724541", "species_113592" ], "products": [ "species_29370", "species_10724523" ], "modifiers": [ [ "species_10724541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10680187": { "compartment": "compartment_7660", "id": "reaction_10680187", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680183" ], "products": [ "species_10680185" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10724539": { "compartment": "compartment_70101", "id": "reaction_10724539", "reactome": "R-DDI-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724527", "species_113592" ], "products": [ "species_29370", "species_10724536" ], "modifiers": [ [ "species_10724527", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10678590": { "compartment": "compartment_876", "id": "reaction_10678590", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678586", "species_10678454" ], "products": [ "species_10678588" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54VD5", "DDB_G0280437", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "species_29438", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724534": { "compartment": "compartment_74700", "id": "reaction_10724534", "reactome": "R-DDI-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10724525" ], "products": [ "species_10724527", "species_29370" ], "modifiers": [ [ "species_10724525", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10724561": { "compartment": "compartment_7660", "id": "reaction_10724561", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10724549" ], "products": [ "species_113582", "species_10724552" ], "modifiers": [ [ "species_10724558", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10724023": { "compartment": "compartment_70101", "id": "reaction_10724023", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9026307" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10724019": { "compartment": "compartment_70101", "id": "reaction_10724019", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026293" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724021": { "compartment": "compartment_70101", "id": "reaction_10724021", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10692055": { "compartment": "compartment_70101", "id": "reaction_10692055", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680794", "species_1497857" ], "products": [ "species_29870", "species_10692053" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680817": { "compartment": "compartment_70101", "id": "reaction_10680817", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680768", "species_10680089" ], "products": [ "species_10680776" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680970": { "compartment": "compartment_20699", "id": "reaction_10680970", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680934" ], "products": [ "species_10680751" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680960": { "compartment": "compartment_876", "id": "reaction_10680960", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751" ], "products": [ "species_76168", "species_10680805" ], "modifiers": [ [ "species_10680957", "catalyst" ] ], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "Q54T49", "DDB_G0282005" ] }, "reaction_10692058": { "compartment": "compartment_70101", "id": "reaction_10692058", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10692053", "catalyst" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680792": { "compartment": "compartment_70101", "id": "reaction_10680792", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680776" ], "products": [ "species_29370", "species_10680790" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10692064": { "compartment": "compartment_70101", "id": "reaction_10692064", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_1497811" ], "products": [ "species_29366", "species_1497857" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10680815": { "compartment": "compartment_20699", "id": "reaction_10680815", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680805" ], "products": [ "species_10680813" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680942": { "compartment": "compartment_20699", "id": "reaction_10680942", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680803", "species_200993" ], "products": [ "species_10680934" ], "modifiers": [ [ "species_10680939", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "DDB_G0278239" ] }, "reaction_10692051": { "compartment": "compartment_70101", "id": "reaction_10692051", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10680790" ], "products": [ "species_10680794" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680797": { "compartment": "compartment_70101", "id": "reaction_10680797", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10680794", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680950": { "compartment": "compartment_70101", "id": "reaction_10680950", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10680948" ], "products": [ "species_10680803" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10685205": { "compartment": "compartment_70101", "id": "reaction_10685205", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10685202", "catalyst" ] ], "additional_components": [ "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769", "Q54HV0", "DDB_G0289175", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q86K90", "DDB_G0277211", "Q54EV5", "DDB_G0291310", "Q54S59", "DDB_G0282793", "Q54VM4", "DDB_G0280251" ] }, "reaction_10690044": { "compartment": "compartment_7660", "id": "reaction_10690044", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690036", "species_10690021" ], "products": [ "species_10690042" ], "modifiers": [], "additional_components": [ "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690384": { "compartment": "compartment_7660", "id": "reaction_10690384", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690021" ], "products": [ "species_10690382" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690040": { "compartment": "compartment_7660", "id": "reaction_10690040", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690036" ], "products": [ "species_10690038" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690376": { "compartment": "compartment_7660", "id": "reaction_10690376", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690372" ], "products": [ "species_10690374" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690388": { "compartment": "compartment_7660", "id": "reaction_10690388", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690019" ], "products": [ "species_10690386" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690380": { "compartment": "compartment_7660", "id": "reaction_10690380", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10689991" ], "products": [ "species_10690378" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679987": { "compartment": "compartment_70101", "id": "reaction_10679987", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10679984", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10679977": { "compartment": "compartment_70101", "id": "reaction_10679977", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10679974", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10701666": { "compartment": "compartment_13231", "id": "reaction_10701666", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10700336", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10699545": { "compartment": "compartment_70101", "id": "reaction_10699545", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699541", "species_10699543" ], "products": [ "species_10699415" ], "modifiers": [], "additional_components": [ "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_113592", "P36415", "DDB_G0269144", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568" ] }, "reaction_10702418": { "compartment": "compartment_70101", "id": "reaction_10702418", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699485" ], "products": [ "species_10702412" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "species_113592", "Q54DA8", "DDB_G0292404", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400" ] }, "reaction_10699420": { "compartment": "compartment_70101", "id": "reaction_10699420", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699415" ], "products": [ "species_10699417", "species_29372" ], "modifiers": [ [ "species_10699415", "catalyst" ], [ "species_10699413", "catalyst" ] ], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10699487": { "compartment": "compartment_70101", "id": "reaction_10699487", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699417", "species_10699479", "species_10699473" ], "products": [ "species_10699413", "species_10699485" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "DDB_G0292404", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400" ] }, "reaction_10678193": { "compartment": "compartment_5460", "id": "reaction_10678193", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678182", "species_73663" ], "products": [ "species_76633", "species_10678180" ], "modifiers": [ [ "species_10678190", "catalyst" ] ], "additional_components": [ "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10677420": { "compartment": "compartment_70616", "id": "reaction_10677420", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_76633", "species_113529", "species_73663" ], "products": [ "species_10677282", "species_76633", "species_163953", "species_73663" ], "modifiers": [ [ "species_10677417", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q54M82", "DDB_G0286171", "Q4W6B5", "DDB_G0288777", "Q86A84", "DDB_G0274809", "Q54D07", "DDB_G0292594", "Q37311", "DDB_G0294078", "Q1ZXP3", "DDB_G0271774", "Q54QR8", "DDB_G0283669", "Q54F93", "DDB_G0290997" ] }, "reaction_10709072": { "compartment": "compartment_5460", "id": "reaction_10709072", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10709068" ], "products": [ "species_10709070" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10714760": { "compartment": "compartment_5460", "id": "reaction_10714760", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714105", "species_10711174", "species_10714098", "species_10714110", "species_10711176" ], "products": [ "species_10714112" ], "modifiers": [], "additional_components": [ "Q559Z0", "DDB_G0272266", "species_113596", "Q54NI6", "DDB_G0285239", "Q54S83", "DDB_G0282615", "Q23883", "DDB_G0294030", "DDB_G0294032", "Q86K57", "DDB_G0277231", "P22237", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "species_113596" ] }, "reaction_10678185": { "compartment": "compartment_5460", "id": "reaction_10678185", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678180", "species_31649" ], "products": [ "species_113596", "species_10678182" ], "modifiers": [ [ "species_10678180", "catalyst" ] ], "additional_components": [ "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10711196": { "compartment": "compartment_5460", "id": "reaction_10711196", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711190", "species_10711185", "species_10709070", "species_76629" ], "products": [ "species_10711194", "species_10711192", "species_10709068" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "Q54F10", "DDB_G0291173", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193" ] }, "reaction_10711180": { "compartment": "compartment_5460", "id": "reaction_10711180", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709070", "species_10711168" ], "products": [ "species_10711178", "species_10709068" ], "modifiers": [], "additional_components": [ "Q54F15", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "DDB_G0291193" ] }, "reaction_10716369": { "compartment": "compartment_7660", "id": "reaction_10716369", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10716366", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10714921": { "compartment": "compartment_7660", "id": "reaction_10714921", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10714909" ], "products": [ "species_113582", "species_10714919" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721110": { "compartment": "compartment_7660", "id": "reaction_10721110", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721103", "species_10687932" ], "products": [ "species_10721108" ], "modifiers": [], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0268618", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q55EZ0", "DDB_G0268618", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10721106": { "compartment": "compartment_7660", "id": "reaction_10721106", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721092", "species_29358" ], "products": [ "species_113582", "species_10721103" ], "modifiers": [ [ "species_10685946", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10716021": { "compartment": "compartment_7660", "id": "reaction_10716021", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700208", "species_6810408" ], "products": [ "species_10716019" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "species_6810408", "Q54PN9", "DDB_G0284411" ] }, "reaction_10671182": { "compartment": "compartment_5460", "id": "reaction_10671182", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10671179", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10722466": { "compartment": "compartment_5460", "id": "reaction_10722466", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10710922", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10690088": { "compartment": "compartment_70101", "id": "reaction_10690088", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10690056": { "compartment": "compartment_70101", "id": "reaction_10690056", "reactome": "R-DDI-1237069", "name": "RHAG transports CO2 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237009" ], "products": [ "species_113528" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10702542": { "compartment": "compartment_70101", "id": "reaction_10702542", "reactome": "R-DDI-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10702540" ], "products": [ "species_10702524", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "species_29438", "Q54V41", "DDB_G0280633", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10723639": { "compartment": "compartment_70101", "id": "reaction_10723639", "reactome": "R-DDI-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723634" ], "products": [ "species_29372", "species_10723636" ], "modifiers": [ [ "species_10723261", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723645": { "compartment": "compartment_70101", "id": "reaction_10723645", "reactome": "R-DDI-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723641", "species_10723634" ], "products": [ "species_10723643" ], "modifiers": [], "additional_components": [ "Q54ND2", "DDB_G0285391", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q55GN5", "DDB_G0267590", "Q54XT6", "DDB_G0278755", "O00899", "DDB_G0269140", "Q54FF4", "DDB_G0290891", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "Q1ZXA8", "DDB_G0292160", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q1ZXJ6", "DDB_G0278011", "Q55GN5", "DDB_G0267590", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "P34145", "DDB_G0268622", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q54XT6", "DDB_G0278755", "species_29438", "O00899", "DDB_G0269140", "Q9GPR7", "DDB_G0269240", "Q54FF4", "DDB_G0290891", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q869N2", "DDB_G0276459" ] }, "reaction_10723650": { "compartment": "compartment_876", "id": "reaction_10723650", "reactome": "R-DDI-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723636" ], "products": [ "species_29420", "species_10723634" ], "modifiers": [ [ "species_10723647", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54PK2", "DDB_G0291085", "Q54F64", "DDB_G0291085", "Q54J11", "DDB_G0288383", "Q54MM3", "DDB_G0285859", "Q54B37", "DDB_G0293978", "Q54KI4", "DDB_G0287325", "Q1ZXN6", "DDB_G0272372" ] }, "reaction_10723940": { "compartment": "compartment_876", "id": "reaction_10723940", "reactome": "R-DDI-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723634" ], "products": [ "species_10723938" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10705788": { "compartment": "compartment_7660", "id": "reaction_10705788", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705770", "species_10705784" ], "products": [ "species_10705786" ], "modifiers": [], "additional_components": [ "Q557E6", "DDB_G0273139", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q1ZXF0", "DDB_G0285287", "Q557E6", "DDB_G0273139", "Q54ED2", "DDB_G0291570", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q54DM3", "DDB_G0292130", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q8T2T7", "DDB_G0275257", "Q1ZXF0", "DDB_G0285287", "Q86IV6", "DDB_G0274777" ] }, "reaction_10705715": { "compartment": "compartment_7660", "id": "reaction_10705715", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705710" ], "products": [ "species_113582", "species_10705713" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10705801": { "compartment": "compartment_7660", "id": "reaction_10705801", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705796" ], "products": [ "species_30555", "species_10705798" ], "modifiers": [ [ "species_10705796", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546" ] }, "reaction_10674992": { "compartment": "compartment_7660", "id": "reaction_10674992", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988" ], "products": [ "species_10674990" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10710990": { "compartment": "compartment_7660", "id": "reaction_10710990", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710986", "species_10710981" ], "products": [ "species_10710988" ], "modifiers": [], "additional_components": [ "DDB_G0293476", "DDB_G0268216", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10722017": { "compartment": "compartment_70101", "id": "reaction_10722017", "reactome": "R-DDI-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722004", "species_113592", "species_10709503" ], "products": [ "species_10722014", "species_111294", "species_76577" ], "modifiers": [ [ "species_10722004", "catalyst" ] ], "additional_components": [ "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722037": { "compartment": "compartment_70101", "id": "reaction_10722037", "reactome": "R-DDI-8951661", "name": "Transfer of NEDD8 to AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722026" ], "products": [ "species_10722034", "species_10722014" ], "modifiers": [ [ "species_10722026", "catalyst" ] ], "additional_components": [ "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722288": { "compartment": "compartment_7660", "id": "reaction_10722288", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722257", "species_10722191", "species_10722245" ], "products": [ "species_10722259" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10709510": { "compartment": "compartment_70101", "id": "reaction_10709510", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709501", "species_29356" ], "products": [ "species_10709507", "species_10709505" ], "modifiers": [ [ "species_10709501", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10722444": { "compartment": "compartment_70101", "id": "reaction_10722444", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10722440" ], "products": [ "species_10722442" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436" ] }, "reaction_10722556": { "compartment": "compartment_7660", "id": "reaction_10722556", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722283" ], "products": [ "species_10722553", "species_10722551" ], "modifiers": [ [ "species_10709642", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q550I8", "DDB_G0277089", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0278711", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10722452": { "compartment": "compartment_7660", "id": "reaction_10722452", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722448", "species_10722243" ], "products": [ "species_10722245", "species_10722446" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "DDB_G0274167" ] }, "reaction_10722571": { "compartment": "compartment_70101", "id": "reaction_10722571", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722567", "species_10722562" ], "products": [ "species_10722569" ], "modifiers": [], "additional_components": [ "DDB_G0270358", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q55BU7", "DDB_G0270358", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201" ] }, "reaction_10722039": { "compartment": "compartment_70101", "id": "reaction_10722039", "reactome": "R-DDI-8951751", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722024", "species_10722019" ], "products": [ "species_10722026" ], "modifiers": [], "additional_components": [ "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722021": { "compartment": "compartment_70101", "id": "reaction_10722021", "reactome": "R-DDI-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10722014", "species_10709503" ], "products": [ "species_111294", "species_76577", "species_10722019" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722450": { "compartment": "compartment_7660", "id": "reaction_10722450", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722219", "species_10722446" ], "products": [ "species_10722448" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "DDB_G0274167", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565" ] }, "reaction_10722460": { "compartment": "compartment_70101", "id": "reaction_10722460", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722118", "species_10722442" ], "products": [ "species_10722458", "species_10709665" ], "modifiers": [], "additional_components": [ "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0274167" ] }, "reaction_10722577": { "compartment": "compartment_876", "id": "reaction_10722577", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722160", "species_10722178" ], "products": [ "species_10722180" ], "modifiers": [], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "DDB_G0290025", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722182": { "compartment": "compartment_70101", "id": "reaction_10722182", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722162" ], "products": [ "species_10722174", "species_10722024" ], "modifiers": [ [ "species_10722162", "catalyst" ], [ "species_10722180", "inhibitor" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722185": { "compartment": "compartment_70101", "id": "reaction_10722185", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722143", "species_10722034", "species_10722160" ], "products": [ "species_10722162" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722286": { "compartment": "compartment_7660", "id": "reaction_10722286", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722259" ], "products": [ "species_10722283", "species_10722261" ], "modifiers": [ [ "species_10722259", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722549": { "compartment": "compartment_70101", "id": "reaction_10722549", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722536" ], "products": [ "species_10722546", "species_10709503" ], "modifiers": [ [ "species_10718564", "catalyst" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q8T2F2", "DDB_G0277439", "Q54DR0", "DDB_G0292074", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0278711", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10721997": { "compartment": "compartment_70101", "id": "reaction_10721997", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709505" ], "products": [ "species_10709192", "species_10709503" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0282007", "DDB_G0278711" ] }, "reaction_10678743": { "compartment": "compartment_70101", "id": "reaction_10678743", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670505", "species_10670510" ], "products": [ "species_10670512" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678860": { "compartment": "compartment_70101", "id": "reaction_10678860", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678797" ], "products": [ "species_10676841", "species_10670505" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0285601", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10680376": { "compartment": "compartment_7660", "id": "reaction_10680376", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10680349" ], "products": [ "species_113582", "species_10680353" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10699967": { "compartment": "compartment_7660", "id": "reaction_10699967", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699958", "species_10669917" ], "products": [ "species_10699964" ], "modifiers": [ [ "species_10699958", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699948": { "compartment": "compartment_7660", "id": "reaction_10699948", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699950": { "compartment": "compartment_7660", "id": "reaction_10699950", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10691859": { "compartment": "compartment_12045", "id": "reaction_10691859", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10691856", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10692020": { "compartment": "compartment_12045", "id": "reaction_10692020", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10692017", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10692009": { "compartment": "compartment_12045", "id": "reaction_10692009", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10692006", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10692047": { "compartment": "compartment_70101", "id": "reaction_10692047", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10692044", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10676812": { "compartment": "compartment_70101", "id": "reaction_10676812", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29356", "species_209914" ], "products": [ "species_29408", "species_29382", "species_500604" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683049": { "compartment": "compartment_5460", "id": "reaction_10683049", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10676257": { "compartment": "compartment_70101", "id": "reaction_10676257", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676252" ], "products": [ "species_10676252" ], "modifiers": [ [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q23917", "DDB_G0284331", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10676146": { "compartment": "compartment_70101", "id": "reaction_10676146", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10676255": { "compartment": "compartment_70101", "id": "reaction_10676255", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676252", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331" ] }, "reaction_10676273": { "compartment": "compartment_70101", "id": "reaction_10676273", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676143", "species_29356" ], "products": [ "species_10676101", "species_29372", "species_10676271" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "DDB_G0292736", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10676198": { "compartment": "compartment_7660", "id": "reaction_10676198", "reactome": "R-DDI-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676189" ], "products": [ "species_113582", "species_10676195" ], "modifiers": [ [ "species_10676189", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831" ] }, "reaction_10676157": { "compartment": "compartment_70101", "id": "reaction_10676157", "reactome": "R-DDI-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_74016", "species_10676153" ], "products": [ "species_10676155" ], "modifiers": [], "additional_components": [ "DDB_G0292858", "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676160": { "compartment": "compartment_12045", "id": "reaction_10676160", "reactome": "R-DDI-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10676155", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676234": { "compartment": "compartment_876", "id": "reaction_10676234", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10676221", "catalyst" ], [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10685523": { "compartment": "compartment_70101", "id": "reaction_10685523", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10685515" ], "products": [ "species_113582", "species_10685520" ], "modifiers": [ [ "species_10685515", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10671131": { "compartment": "compartment_5460", "id": "reaction_10671131", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10682718": { "compartment": "compartment_70101", "id": "reaction_10682718", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10682713", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10671817": { "compartment": "compartment_70101", "id": "reaction_10671817", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10671014": { "compartment": "compartment_70101", "id": "reaction_10671014", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29800" ], "products": [ "species_29578", "species_29360", "species_29372" ], "modifiers": [ [ "species_10670947", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10682769": { "compartment": "compartment_5460", "id": "reaction_10682769", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10682766", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10682774": { "compartment": "compartment_70101", "id": "reaction_10682774", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10670994": { "compartment": "compartment_70101", "id": "reaction_10670994", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670989", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10671814": { "compartment": "compartment_70101", "id": "reaction_10671814", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10671811", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10671030": { "compartment": "compartment_70101", "id": "reaction_10671030", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10671027", "catalyst" ] ], "additional_components": [ "Q9GPM4", "DDB_G0287595", "species_29926" ] }, "reaction_10680112": { "compartment": "compartment_70101", "id": "reaction_10680112", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10682918": { "compartment": "compartment_70101", "id": "reaction_10682918", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10671010": { "compartment": "compartment_70101", "id": "reaction_10671010", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10671007", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10670833": { "compartment": "compartment_70101", "id": "reaction_10670833", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10670830", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10680122": { "compartment": "compartment_70101", "id": "reaction_10680122", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10680119", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10671057": { "compartment": "compartment_70101", "id": "reaction_10671057", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29492", "species_29356" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10671054", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "species_29926", "Q55F83", "DDB_G0268214" ] }, "reaction_10671012": { "compartment": "compartment_70101", "id": "reaction_10671012", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10670957", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10698893": { "compartment": "compartment_70101", "id": "reaction_10698893", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698875" ], "products": [ "species_10698877" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698891": { "compartment": "compartment_70101", "id": "reaction_10698891", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698877" ], "products": [ "species_10698889" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698905": { "compartment": "compartment_70101", "id": "reaction_10698905", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10698903" ], "products": [ "species_10698875", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10690190": { "compartment": "compartment_876", "id": "reaction_10690190", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690187", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10691628": { "compartment": "compartment_12045", "id": "reaction_10691628", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691786": { "compartment": "compartment_12045", "id": "reaction_10691786", "reactome": "R-DDI-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691783": { "compartment": "compartment_12045", "id": "reaction_10691783", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691780", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691768": { "compartment": "compartment_12045", "id": "reaction_10691768", "reactome": "R-DDI-1482827", "name": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691760": { "compartment": "compartment_12045", "id": "reaction_10691760", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691757", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858", "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691643": { "compartment": "compartment_12045", "id": "reaction_10691643", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10720446": { "compartment": "compartment_12045", "id": "reaction_10720446", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10720443", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "DDB_G0275665" ] }, "reaction_10676046": { "compartment": "compartment_7660", "id": "reaction_10676046", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676042" ], "products": [ "species_10676044", "species_10675681" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10676048": { "compartment": "compartment_7660", "id": "reaction_10676048", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675681" ], "products": [ "species_10676042" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10725757": { "compartment": "compartment_7660", "id": "reaction_10725757", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725753", "species_10677256" ], "products": [ "species_10725755" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10697242": { "compartment": "compartment_7660", "id": "reaction_10697242", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697226", "species_29358" ], "products": [ "species_113582", "species_10697239" ], "modifiers": [ [ "species_10697226", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10696648": { "compartment": "compartment_7660", "id": "reaction_10696648", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696641", "species_113685" ], "products": [ "species_10696645", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10696641", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10696618": { "compartment": "compartment_7660", "id": "reaction_10696618", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696614", "species_10670680" ], "products": [ "species_10696616" ], "modifiers": [], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "DDB_G0290551", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697218": { "compartment": "compartment_7660", "id": "reaction_10697218", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696635", "species_10696614" ], "products": [ "species_10697216" ], "modifiers": [ [ "species_10696616", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697246": { "compartment": "compartment_7660", "id": "reaction_10697246", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676882", "species_10697244" ], "products": [ "species_10697226" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10688018": { "compartment": "compartment_70101", "id": "reaction_10688018", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10684031", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10682708": { "compartment": "compartment_70101", "id": "reaction_10682708", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10682705", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "species_74016", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10695705": { "compartment": "compartment_17957", "id": "reaction_10695705", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046048" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695686": { "compartment": "compartment_12045", "id": "reaction_10695686", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695701": { "compartment": "compartment_12045", "id": "reaction_10695701", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10695703": { "compartment": "compartment_17957", "id": "reaction_10695703", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695707": { "compartment": "compartment_12045", "id": "reaction_10695707", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10695771": { "compartment": "compartment_161320", "id": "reaction_10695771", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10693345": { "compartment": "compartment_17938", "id": "reaction_10693345", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_76194", "species_2090069" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10693855": { "compartment": "compartment_20699", "id": "reaction_10693855", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10693824" ], "products": [ "species_205687", "species_10693831" ], "modifiers": [ [ "species_10693852", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269900", "Q55DR5", "DDB_G0269900", "Q55CU3", "DDB_G0269900" ] }, "reaction_10693373": { "compartment": "compartment_161320", "id": "reaction_10693373", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10695363": { "compartment": "compartment_20699", "id": "reaction_10695363", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695342", "species_741440" ], "products": [ "species_10695349", "species_742343" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695757": { "compartment": "compartment_20699", "id": "reaction_10695757", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695744", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695773": { "compartment": "compartment_161320", "id": "reaction_10695773", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10693365": { "compartment": "compartment_161320", "id": "reaction_10693365", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090033" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10695445": { "compartment": "compartment_17963", "id": "reaction_10695445", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695411" ], "products": [ "species_10695443" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695373": { "compartment": "compartment_20699", "id": "reaction_10695373", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695370", "species_2022884" ], "products": [ "species_10695342", "species_2022890" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695775": { "compartment": "compartment_17938", "id": "reaction_10695775", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090045", "species_76183" ], "products": [ "species_76194", "species_2090053" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10695742": { "compartment": "compartment_17963", "id": "reaction_10695742", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695737", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695375": { "compartment": "compartment_876", "id": "reaction_10695375", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693351" ], "products": [ "species_10692697" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695769": { "compartment": "compartment_161320", "id": "reaction_10695769", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090055", "species_1605715" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10686016": { "compartment": "compartment_70101", "id": "reaction_10686016", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10686011", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10716925": { "compartment": "compartment_20699", "id": "reaction_10716925", "reactome": "R-DDI-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10684974", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10716046": { "compartment": "compartment_20699", "id": "reaction_10716046", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715737", "species_10715128" ], "products": [ "species_10716031" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716035": { "compartment": "compartment_20699", "id": "reaction_10716035", "reactome": "R-DDI-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716031", "species_10715194" ], "products": [ "species_10716033" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716071": { "compartment": "compartment_20699", "id": "reaction_10716071", "reactome": "R-DDI-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716056" ], "products": [ "species_10715128", "species_10715276", "species_10715194", "species_10716068" ], "modifiers": [ [ "species_10716056", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10717044": { "compartment": "compartment_12045", "id": "reaction_10717044", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717040", "species_10717028" ], "products": [ "species_10717042" ], "modifiers": [], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716044": { "compartment": "compartment_20699", "id": "reaction_10716044", "reactome": "R-DDI-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716033" ], "products": [ "species_10716037", "species_29420" ], "modifiers": [ [ "species_10716033", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716093": { "compartment": "compartment_12045", "id": "reaction_10716093", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716090", "species_113592" ], "products": [ "species_10716076", "species_10716081", "species_10681096", "species_10710119", "species_10716086", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10716090", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111", "DDB_G0267646", "DDB_G0281429", "DDB_G0269942", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716214": { "compartment": "compartment_12045", "id": "reaction_10716214", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716212", "species_10710119", "species_10710110" ], "products": [ "species_10716090" ], "modifiers": [], "additional_components": [ "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716058": { "compartment": "compartment_20699", "id": "reaction_10716058", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715775", "species_10715276", "species_10716054", "species_10716039", "species_10716048" ], "products": [ "species_10716056" ], "modifiers": [], "additional_components": [ "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "DDB_G0269942", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716041": { "compartment": "compartment_20699", "id": "reaction_10716041", "reactome": "R-DDI-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716037", "species_10715256" ], "products": [ "species_10716039" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716957": { "compartment": "compartment_20699", "id": "reaction_10716957", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848483", "species_548819" ], "products": [ "species_76194", "species_429785" ], "modifiers": [ [ "species_10716954", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10717053": { "compartment": "compartment_12045", "id": "reaction_10717053", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10717042" ], "products": [ "species_10717050", "species_29420" ], "modifiers": [ [ "species_10717042", "catalyst" ] ], "additional_components": [ "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "species_29438", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716216": { "compartment": "compartment_12045", "id": "reaction_10716216", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716210" ], "products": [ "species_10716168", "species_10716208", "species_10716212", "species_10715256", "species_10710015" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q55CJ0", "DDB_G0270040", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54TZ2", "DDB_G0281429", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q54YZ1", "DDB_G0277997", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q55CA1", "DDB_G0270150", "Q23924", "DDB_G0284735", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10682380": { "compartment": "compartment_70101", "id": "reaction_10682380", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10682377", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10684029": { "compartment": "compartment_17940", "id": "reaction_10684029", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684027" ], "products": [ "species_10684027" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10709972": { "compartment": "compartment_5460", "id": "reaction_10709972", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_159549" ], "products": [ "species_10709961", "species_29376" ], "modifiers": [ [ "species_10709969", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:14949", "Q54JV8", "DDB_G0287773", "Q54KM7", "DDB_G0287255" ] }, "reaction_10709982": { "compartment": "compartment_5460", "id": "reaction_10709982", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709961", "species_200671" ], "products": [ "species_5693984", "species_10709974", "species_5693978" ], "modifiers": [ [ "species_10709979", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q54JV8", "DDB_G0287773", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10709987": { "compartment": "compartment_5460", "id": "reaction_10709987", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709974", "species_113526" ], "products": [ "species_10709957", "species_29362", "species_113529" ], "modifiers": [ [ "species_10709984", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10684177": { "compartment": "compartment_70101", "id": "reaction_10684177", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10684174", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10684192": { "compartment": "compartment_70101", "id": "reaction_10684192", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10684189", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10716937": { "compartment": "compartment_12045", "id": "reaction_10716937", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683793": { "compartment": "compartment_17951", "id": "reaction_10683793", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10716935": { "compartment": "compartment_12045", "id": "reaction_10716935", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10710365": { "compartment": "compartment_12045", "id": "reaction_10710365", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10710362", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683791": { "compartment": "compartment_17951", "id": "reaction_10683791", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10681884": { "compartment": "compartment_70101", "id": "reaction_10681884", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209793", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209934" ], "modifiers": [ [ "species_10681881", "catalyst" ] ], "additional_components": [ "DDB_G0289329" ] }, "reaction_10681900": { "compartment": "compartment_70101", "id": "reaction_10681900", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10681897", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10703615": { "compartment": "compartment_17938", "id": "reaction_10703615", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703600", "species_113592" ], "products": [ "species_29370", "species_10703612" ], "modifiers": [ [ "species_10703600", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725704": { "compartment": "compartment_17947", "id": "reaction_10725704", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725700" ], "products": [ "species_10725702" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704870": { "compartment": "compartment_70101", "id": "reaction_10704870", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704868" ], "products": [ "species_10704836" ], "modifiers": [], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10724968": { "compartment": "compartment_70101", "id": "reaction_10724968", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724940" ], "products": [ "species_10724966" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10722608": { "compartment": "compartment_70101", "id": "reaction_10722608", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722600", "species_10721824" ], "products": [ "species_10722602" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0277699", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699" ] }, "reaction_10704860": { "compartment": "compartment_70101", "id": "reaction_10704860", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10704857", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721818": { "compartment": "compartment_17906", "id": "reaction_10721818", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703459" ], "products": [ "species_10721816" ], "modifiers": [], "additional_components": [ "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10722606": { "compartment": "compartment_21994", "id": "reaction_10722606", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722602", "species_10701260" ], "products": [ "species_10722604" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q75K07", "DDB_G0277699" ] }, "reaction_10721827": { "compartment": "compartment_17906", "id": "reaction_10721827", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_29370", "species_10721824" ], "modifiers": [ [ "species_10721816", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10703635": { "compartment": "compartment_17938", "id": "reaction_10703635", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10724956": { "compartment": "compartment_70101", "id": "reaction_10724956", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724954" ], "products": [ "species_10724952", "species_10724944" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725708": { "compartment": "compartment_70101", "id": "reaction_10725708", "reactome": "R-DDI-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725652" ], "products": [ "species_10725677" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10725712": { "compartment": "compartment_70101", "id": "reaction_10725712", "reactome": "R-DDI-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725659", "species_10725669" ], "products": [ "species_10725671" ], "modifiers": [], "additional_components": [ "DDB_G0270098", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10724932": { "compartment": "compartment_70101", "id": "reaction_10724932", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689017", "species_10724928" ], "products": [ "species_10724930" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704855": { "compartment": "compartment_70101", "id": "reaction_10704855", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704836" ], "products": [ "species_29370", "species_10703627" ], "modifiers": [ [ "species_10704852", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10703630": { "compartment": "compartment_12045", "id": "reaction_10703630", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10703627", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10704806": { "compartment": "compartment_70101", "id": "reaction_10704806", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704781", "species_5681998" ], "products": [ "species_10704783", "species_10704785" ], "modifiers": [ [ "species_10704803", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "DDB_G0277319", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10725698": { "compartment": "compartment_17947", "id": "reaction_10725698", "reactome": "R-DDI-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725661", "species_10725677" ], "products": [ "species_10725679" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703598": { "compartment": "compartment_70101", "id": "reaction_10703598", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703495" ], "products": [ "species_29370", "species_10703595" ], "modifiers": [ [ "species_10703495", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704672": { "compartment": "compartment_74700", "id": "reaction_10704672", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704214" ], "products": [ "species_10677585", "species_10703610" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10703639": { "compartment": "compartment_70101", "id": "reaction_10703639", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_10703473" ], "products": [ "species_10703600" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725696": { "compartment": "compartment_17947", "id": "reaction_10725696", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725692" ], "products": [ "species_10725694" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0284133", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q86CR8", "DDB_G0286191" ] }, "reaction_10721810": { "compartment": "compartment_70101", "id": "reaction_10721810", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_10721808", "species_29370" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10704947": { "compartment": "compartment_70101", "id": "reaction_10704947", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704916" ], "products": [ "species_10704773" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10725687": { "compartment": "compartment_17947", "id": "reaction_10725687", "reactome": "R-DDI-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725679" ], "products": [ "species_10725685" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705356": { "compartment": "compartment_70101", "id": "reaction_10705356", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703610" ], "products": [ "species_10703473", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10704862": { "compartment": "compartment_70101", "id": "reaction_10704862", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704681" ], "products": [ "species_10704852" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10723993": { "compartment": "compartment_70101", "id": "reaction_10723993", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704874" ], "products": [ "species_10705267" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10724970": { "compartment": "compartment_70101", "id": "reaction_10724970", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724966" ], "products": [ "species_10724954" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704216": { "compartment": "compartment_70101", "id": "reaction_10704216", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703612" ], "products": [ "species_29370", "species_10704214" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10704876": { "compartment": "compartment_70101", "id": "reaction_10704876", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704792" ], "products": [ "species_10704874" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10705132": { "compartment": "compartment_70101", "id": "reaction_10705132", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10704773", "species_5681998" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10704949": { "compartment": "compartment_70101", "id": "reaction_10704949", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704773" ], "products": [ "species_10704883" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191" ] }, "reaction_10725706": { "compartment": "compartment_17947", "id": "reaction_10725706", "reactome": "R-DDI-9664881", "name": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725671", "species_10725692" ], "products": [ "species_10725700" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "DDB_G0284133", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704704": { "compartment": "compartment_70101", "id": "reaction_10704704", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704700", "species_5693050" ], "products": [ "species_10704702" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54SA0", "DDB_G0282581", "Q54NA2", "DDB_G0285375", "species_1806159", "Q54SA0", "DDB_G0282581" ] }, "reaction_10705183": { "compartment": "compartment_5683628", "id": "reaction_10705183", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10705174" ], "modifiers": [ [ "species_10705181", "catalyst" ], [ "species_10687292", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "P54676", "DDB_G0289601", "Q54JC5", "DDB_G0288175", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087" ] }, "reaction_10704864": { "compartment": "compartment_70101", "id": "reaction_10704864", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704801", "species_10704799" ], "products": [ "species_10704803" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10705335": { "compartment": "compartment_70101", "id": "reaction_10705335", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704887" ], "products": [ "species_10704872", "species_10704781" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10725710": { "compartment": "compartment_17947", "id": "reaction_10725710", "reactome": "R-DDI-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725685" ], "products": [ "species_10725669" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703498": { "compartment": "compartment_70101", "id": "reaction_10703498", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703475", "species_113592" ], "products": [ "species_29370", "species_10703495" ], "modifiers": [ [ "species_10703475", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10725654": { "compartment": "compartment_70101", "id": "reaction_10725654", "reactome": "R-DDI-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724145", "species_10725650" ], "products": [ "species_10725652" ], "modifiers": [], "additional_components": [ "DDB_G0286033", "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705269": { "compartment": "compartment_70101", "id": "reaction_10705269", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704883", "species_10704785" ], "products": [ "species_10704885" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10724942": { "compartment": "compartment_70101", "id": "reaction_10724942", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724938", "species_10724930" ], "products": [ "species_10724940" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725675": { "compartment": "compartment_17947", "id": "reaction_10725675", "reactome": "R-DDI-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725671" ], "products": [ "species_10725673" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10705145": { "compartment": "compartment_12045", "id": "reaction_10705145", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703627" ], "products": [ "species_10705136" ], "modifiers": [ [ "species_10705141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "DDB_G0285323" ] }, "reaction_10703617": { "compartment": "compartment_70101", "id": "reaction_10703617", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703473", "species_10683107" ], "products": [ "species_10703475" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704890": { "compartment": "compartment_70101", "id": "reaction_10704890", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704885" ], "products": [ "species_10704887" ], "modifiers": [ [ "species_10704885", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10704684": { "compartment": "compartment_70101", "id": "reaction_10704684", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703595" ], "products": [ "species_29370", "species_10704681" ], "modifiers": [ [ "species_10703595", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10714394": { "compartment": "compartment_70101", "id": "reaction_10714394", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10714372" ], "products": [ "species_71285", "species_10714379" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10709680": { "compartment": "compartment_70101", "id": "reaction_10709680", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10709677", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10725743": { "compartment": "compartment_70101", "id": "reaction_10725743", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683047", "species_113592", "species_29356" ], "products": [ "species_10683043", "species_29370", "species_29372" ], "modifiers": [ [ "species_10725732", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725738": { "compartment": "compartment_13231", "id": "reaction_10725738", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725728", "species_10725722" ], "products": [ "species_10725730" ], "modifiers": [], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "DDB_G0283793", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725736": { "compartment": "compartment_70101", "id": "reaction_10725736", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687703", "species_10725732" ], "products": [ "species_10725734" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54PT2", "DDB_G0284347", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724709": { "compartment": "compartment_1598585", "id": "reaction_10724709", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681066" ], "products": [ "species_10724701", "species_29420" ], "modifiers": [ [ "species_10724706", "catalyst" ] ], "additional_components": [ "species_29420", "P33519", "DDB_G0291235", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10698508": { "compartment": "compartment_13231", "id": "reaction_10698508", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698490" ], "products": [ "species_10698305", "species_10698505" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54N16", "DDB_G0285563", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10724716": { "compartment": "compartment_70101", "id": "reaction_10724716", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724711", "species_29356" ], "products": [ "species_10681066", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10698505", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "species_29420", "P33519", "DDB_G0291235", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10725740": { "compartment": "compartment_70101", "id": "reaction_10725740", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725717", "species_10725730" ], "products": [ "species_10725732" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724713": { "compartment": "compartment_70101", "id": "reaction_10724713", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10724701" ], "products": [ "species_10724711" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10670890": { "compartment": "compartment_70101", "id": "reaction_10670890", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10670880": { "compartment": "compartment_70101", "id": "reaction_10670880", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10670877", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10716376": { "compartment": "compartment_70101", "id": "reaction_10716376", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10670900": { "compartment": "compartment_70101", "id": "reaction_10670900", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10670897", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10702192": { "compartment": "compartment_7660", "id": "reaction_10702192", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_10702188", "species_10702174" ], "products": [ "species_10702190" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702289": { "compartment": "compartment_7660", "id": "reaction_10702289", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702167", "species_10702172" ], "products": [ "species_10702174" ], "modifiers": [], "additional_components": [ "DDB_G0287393", "DDB_G0283981", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393" ] }, "reaction_10702208": { "compartment": "compartment_7660", "id": "reaction_10702208", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702190" ], "products": [ "species_10702205" ], "modifiers": [ [ "species_10702190", "catalyst" ] ], "additional_components": [ "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702287": { "compartment": "compartment_7660", "id": "reaction_10702287", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702184" ], "products": [ "species_10702210" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0268614", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702227": { "compartment": "compartment_7660", "id": "reaction_10702227", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702212", "species_29358" ], "products": [ "species_113582", "species_10702188" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702285": { "compartment": "compartment_7660", "id": "reaction_10702285", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702197" ], "products": [ "species_10702199" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0281683", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702203": { "compartment": "compartment_7660", "id": "reaction_10702203", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10702199" ], "products": [ "species_10702201" ], "modifiers": [], "additional_components": [ "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702216": { "compartment": "compartment_7660", "id": "reaction_10702216", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10702214": { "compartment": "compartment_7660", "id": "reaction_10702214", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702210", "species_5358514" ], "products": [ "species_10702212" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702225": { "compartment": "compartment_7660", "id": "reaction_10702225", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702221", "species_10702205" ], "products": [ "species_10702223" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10675582": { "compartment": "compartment_7660", "id": "reaction_10675582", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675580", "species_10675574" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0289199", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10675587": { "compartment": "compartment_7660", "id": "reaction_10675587", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10675584" ], "products": [ "species_113582", "species_10675580" ], "modifiers": [ [ "species_10675584", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10676478": { "compartment": "compartment_7660", "id": "reaction_10676478", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675584" ], "products": [ "species_10675584" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10675602": { "compartment": "compartment_7660", "id": "reaction_10675602", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675592", "species_10675576", "species_10675598" ], "products": [ "species_10675600" ], "modifiers": [], "additional_components": [ "DDB_G0278479", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0287661", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675578": { "compartment": "compartment_7660", "id": "reaction_10675578", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675576" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10670593": { "compartment": "compartment_7660", "id": "reaction_10670593", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670586" ], "products": [ "species_10670590" ], "modifiers": [ [ "species_10670584", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609" ] }, "reaction_10670597": { "compartment": "compartment_7660", "id": "reaction_10670597", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670590" ], "products": [ "species_10670595" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670617": { "compartment": "compartment_7660", "id": "reaction_10670617", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10670609": { "compartment": "compartment_7660", "id": "reaction_10670609", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670599" ], "products": [ "species_10670601" ], "modifiers": [ [ "species_10670606", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "DDB_G0284987" ] }, "reaction_10688208": { "compartment": "compartment_20699", "id": "reaction_10688208", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688218": { "compartment": "compartment_20699", "id": "reaction_10688218", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688220": { "compartment": "compartment_20699", "id": "reaction_10688220", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688216": { "compartment": "compartment_20699", "id": "reaction_10688216", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10688213", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10686090": { "compartment": "compartment_70101", "id": "reaction_10686090", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686088" ], "products": [], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0275027", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10686077": { "compartment": "compartment_70101", "id": "reaction_10686077", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686071", "species_450444" ], "products": [ "species_10686075" ], "modifiers": [], "additional_components": [ "Q86I71", "DDB_G0275027", "Q86I71", "DDB_G0275027" ] }, "reaction_10686313": { "compartment": "compartment_876", "id": "reaction_10686313", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686265" ], "products": [ "species_10686311" ], "modifiers": [], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758" ] }, "reaction_10686448": { "compartment": "compartment_876", "id": "reaction_10686448", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686424" ], "products": [ "species_10686446" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569" ] }, "reaction_10682506": { "compartment": "compartment_161320", "id": "reaction_10682506", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682498" ], "products": [ "species_10682504" ], "modifiers": [], "additional_components": [ "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417", "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417" ] }, "reaction_10686372": { "compartment": "compartment_876", "id": "reaction_10686372", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686352" ], "products": [ "species_10686370" ], "modifiers": [], "additional_components": [ "P04988", "DDB_G0290957", "species_74016", "species_29370", "CHEBI:15996", "species_111349", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436", "P04988", "DDB_G0290957", "species_74016", "species_29370", "species_29438", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29420", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436" ] }, "reaction_10686484": { "compartment": "compartment_876", "id": "reaction_10686484", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686472" ], "products": [ "species_10686482" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10686628": { "compartment": "compartment_70101", "id": "reaction_10686628", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686552" ], "products": [ "species_10686626" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507" ] }, "reaction_10701635": { "compartment": "compartment_70101", "id": "reaction_10701635", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701632", "species_113592" ], "products": [ "species_10679174", "species_29370", "species_10678454", "species_5218688" ], "modifiers": [ [ "species_10701626", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_428193", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0284545" ] }, "reaction_10725915": { "compartment": "compartment_70101", "id": "reaction_10725915", "reactome": "R-DDI-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725899" ], "products": [ "species_10725913" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10725936": { "compartment": "compartment_7660", "id": "reaction_10725936", "reactome": "R-DDI-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10725931" ], "products": [ "species_10725913", "species_427486" ], "modifiers": [ [ "species_10725933", "catalyst" ] ], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q55FN5", "DDB_G0268024", "Q55BW2", "DDB_G0270338" ] }, "reaction_10677104": { "compartment": "compartment_70101", "id": "reaction_10677104", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10677101", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10675817": { "compartment": "compartment_70101", "id": "reaction_10675817", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10675791" ], "products": [ "species_29370", "species_10675814" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10680170": { "compartment": "compartment_70101", "id": "reaction_10680170", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680149" ], "products": [ "species_29370", "species_10680079" ], "modifiers": [ [ "species_10680163", "catalyst" ], [ "species_10680168", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10697254": { "compartment": "compartment_876", "id": "reaction_10697254", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680079", "species_10675800" ], "products": [ "species_10680081" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10697252": { "compartment": "compartment_70101", "id": "reaction_10697252", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10725901": { "compartment": "compartment_70101", "id": "reaction_10725901", "reactome": "R-DDI-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725897" ], "products": [ "species_10725899" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10674483": { "compartment": "compartment_17940", "id": "reaction_10674483", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10690303": { "compartment": "compartment_70101", "id": "reaction_10690303", "reactome": "R-DDI-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10690293" ], "products": [ "species_29370", "species_10690301" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10680102": { "compartment": "compartment_70101", "id": "reaction_10680102", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680081", "species_113592" ], "products": [ "species_29370", "species_10680099", "species_10675800" ], "modifiers": [ [ "species_10680081", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10675793": { "compartment": "compartment_876", "id": "reaction_10675793", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675789" ], "products": [ "species_10675775", "species_10675791" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10714853": { "compartment": "compartment_7660", "id": "reaction_10714853", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672464", "species_10672420", "species_10714849" ], "products": [ "species_10714851" ], "modifiers": [], "additional_components": [ "DDB_G0284321", "DDB_G0280393", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54PW8", "DDB_G0284321", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54VI2", "DDB_G0280393" ] }, "reaction_10675802": { "compartment": "compartment_876", "id": "reaction_10675802", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675798" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10693751": { "compartment": "compartment_70101", "id": "reaction_10693751", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693634": { "compartment": "compartment_70101", "id": "reaction_10693634", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693551": { "compartment": "compartment_70101", "id": "reaction_10693551", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693631": { "compartment": "compartment_70101", "id": "reaction_10693631", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693543": { "compartment": "compartment_70101", "id": "reaction_10693543", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693711": { "compartment": "compartment_70101", "id": "reaction_10693711", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_994149", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693620": { "compartment": "compartment_70101", "id": "reaction_10693620", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10693617", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10693742": { "compartment": "compartment_70101", "id": "reaction_10693742", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10690279": { "compartment": "compartment_876", "id": "reaction_10690279", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690276", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690258": { "compartment": "compartment_876", "id": "reaction_10690258", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690255", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690146": { "compartment": "compartment_876", "id": "reaction_10690146", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690143", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10690247": { "compartment": "compartment_876", "id": "reaction_10690247", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690244", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690159": { "compartment": "compartment_876", "id": "reaction_10690159", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690156", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10690197": { "compartment": "compartment_876", "id": "reaction_10690197", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690194", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255" ] }, "reaction_10690226": { "compartment": "compartment_876", "id": "reaction_10690226", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690223", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10678283": { "compartment": "compartment_876", "id": "reaction_10678283", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678272", "species_10678254" ], "products": [ "species_10678274" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10684258": { "compartment": "compartment_876", "id": "reaction_10684258", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682952", "species_352003" ], "products": [ "species_10682954" ], "modifiers": [], "additional_components": [ "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_916850", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356" ] }, "reaction_10678281": { "compartment": "compartment_876", "id": "reaction_10678281", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_10678278", "species_29372" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678307": { "compartment": "compartment_876", "id": "reaction_10678307", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_29372", "species_10678292" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678294": { "compartment": "compartment_876", "id": "reaction_10678294", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678292" ], "products": [ "species_10676221", "species_10678276", "species_10678290" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10672907": { "compartment": "compartment_7660", "id": "reaction_10672907", "reactome": "R-DDI-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672894", "species_10672779", "species_10672899", "species_10672884", "species_10672879", "species_10672889", "species_10672874" ], "products": [ "species_10672755", "species_10672287", "species_10672241", "species_10672598", "species_10672340", "species_10672335", "species_10672760", "species_10672345", "species_10672905" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q54WN2", "DDB_G0279535", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54HF6", "DDB_G0289499", "Q55FQ0", "DDB_G0268004", "Q9NI62", "DDB_G0269216", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54BG2", "DDB_G0293636", "Q55EC6", "DDB_G0269300", "Q54R72", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672931", "species_10676865" ], "products": [ "species_10672949" ], "modifiers": [], "additional_components": [ "Q55E21", "DDB_G0270866", "Q54ME8", "DDB_G0286007", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54WZ0", "DDB_G0279311", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q1ZXF6", "DDB_G0284555", "Q54DH7", "DDB_G0292244", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "Q55E21", "DDB_G0270866", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q54WZ0", "DDB_G0279311", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q55AR8", "DDB_G0271788", "Q54J75", "DDB_G0288257", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54NJ4", "DDB_G0285213", "Q54CT3", "DDB_G0292778", "P35084", "DDB_G0279193", "Q54WP9", "DDB_G0279507", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54ME8", "DDB_G0286007", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q86A14", "DDB_G0272676", "Q54ZS8", "DDB_G0277371", "Q55BL6", "DDB_G0270450", "Q54CN1", "DDB_G0292846", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54GS9", "DDB_G0289933", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q54R66", "DDB_G0283365", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "C7G084", "DDB_G0295793", "Q54PX3", "DDB_G0291966", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10672912": { "compartment": "compartment_7660", "id": "reaction_10672912", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672905" ], "products": [ "species_10672909", "species_10672899" ], "modifiers": [ [ "species_10672905", "catalyst" ] ], "additional_components": [ "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "DDB_G0268358", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10683372": { "compartment": "compartment_12045", "id": "reaction_10683372", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683362" ], "products": [ "species_10683370" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10683430": { "compartment": "compartment_876", "id": "reaction_10683430", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683426", "species_30389" ], "products": [ "species_10683428" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683348": { "compartment": "compartment_876", "id": "reaction_10683348", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10683344" ], "products": [ "species_10683346" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683434": { "compartment": "compartment_70101", "id": "reaction_10683434", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10683432" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10683428", "catalyst" ], [ "species_10683346", "catalyst" ] ], "additional_components": [ "species_111349", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10679921": { "compartment": "compartment_12045", "id": "reaction_10679921", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10725767": { "compartment": "compartment_984", "id": "reaction_10725767", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9673044", "species_109276" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10725765": { "compartment": "compartment_984", "id": "reaction_10725765", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_9673044", "species_109276" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10686978": { "compartment": "compartment_70101", "id": "reaction_10686978", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686974", "species_10686972" ], "products": [ "species_10686976" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10686985": { "compartment": "compartment_876", "id": "reaction_10686985", "reactome": "R-DDI-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10686982", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10690134": { "compartment": "compartment_70101", "id": "reaction_10690134", "reactome": "R-DDI-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690130", "species_10673826" ], "products": [ "species_10690132" ], "modifiers": [], "additional_components": [ "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "Q86KB1", "DDB_G0274395", "Q54HT7", "DDB_G0289229", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "P29447", "DDB_G0294489", "Q86KB1", "DDB_G0274395", "Q1ZXE0", "DDB_G0287849", "Q54HT7", "DDB_G0289229" ] }, "reaction_10690136": { "compartment": "compartment_70101", "id": "reaction_10690136", "reactome": "R-DDI-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673826", "species_1250243" ], "products": [ "species_10673820" ], "modifiers": [], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849" ] }, "reaction_10684160": { "compartment": "compartment_876", "id": "reaction_10684160", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10684157", "catalyst" ] ], "additional_components": [ "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473" ] }, "reaction_10711700": { "compartment": "compartment_7660", "id": "reaction_10711700", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711648" ], "products": [ "species_10711656" ], "modifiers": [ [ "species_10711697", "catalyst" ], [ "species_10711680", "catalyst" ], [ "species_10711695", "catalyst" ], [ "species_10711661", "catalyst" ] ], "additional_components": [ "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q86IE2", "DDB_G0275633", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55AW0", "DDB_G0271572", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54ZS3", "DDB_G0277279", "Q54N99", "DDB_G0285377", "DDB_G0284053", "DDB_G0275633", "DDB_G0271572" ] }, "reaction_10711868": { "compartment": "compartment_70101", "id": "reaction_10711868", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711840", "species_10711842" ], "products": [ "species_10711850", "species_10711856", "species_10711854", "species_10673208", "species_10711848", "species_10711846", "species_10711860", "species_10711852", "species_10711844", "species_10711842", "species_10711858" ], "modifiers": [ [ "species_10711848", "catalyst" ], [ "species_10711860", "catalyst" ], [ "species_10711866", "catalyst" ], [ "species_10711858", "catalyst" ] ], "additional_components": [ "Q54K66", "DDB_G0287557", "Q54GC0", "DDB_G0290281", "Q76P36", "DDB_G0272308", "Q54W91", "DDB_G0279821", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q54T05", "DDB_G0282099", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q8T1D4", "DDB_G0275601", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q3ZE13", "DDB_G0269980", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54IS0", "DDB_G0288565", "P46793", "DDB_G0276457", "Q556Y4", "DDB_G0273059", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "Q54U04", "DDB_G0281409", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54VD8", "DDB_G0280431", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "O77082", "DDB_G0286117", "Q54YA7", "DDB_G0278331", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54W23", "DDB_G0279961", "Q54I41", "DDB_G0289025", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0280431", "DDB_G0287557", "DDB_G0280431", "DDB_G0278331", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0282099", "DDB_G0288565", "DDB_G0280431", "DDB_G0273059", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10711424": { "compartment": "compartment_7660", "id": "reaction_10711424", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711408" ], "products": [ "species_10711387" ], "modifiers": [ [ "species_10711383", "catalyst" ], [ "species_10711406", "catalyst" ], [ "species_10711378", "catalyst" ], [ "species_10711422", "catalyst" ] ], "additional_components": [ "Q54TD8", "DDB_G0281839", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54W52", "DDB_G0279903", "Q54IM3", "DDB_G0288659", "Q54HJ2", "DDB_G0289415", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54IM3", "DDB_G0288659", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "DDB_G0277945", "Q54TD8", "DDB_G0281839", "Q54W52", "DDB_G0279903", "Q54HJ2", "DDB_G0289415", "DDB_G0272176", "Q54P34", "DDB_G0284817", "Q54KS4", "DDB_G0287147", "Q54HJ2", "DDB_G0289415" ] }, "reaction_10683571": { "compartment": "compartment_17951", "id": "reaction_10683571", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10683568", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10716318": { "compartment": "compartment_70101", "id": "reaction_10716318", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680089", "species_29356" ], "products": [ "species_10683769", "species_29372" ], "modifiers": [ [ "species_10716315", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10692828": { "compartment": "compartment_876", "id": "reaction_10692828", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692825", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693245": { "compartment": "compartment_876", "id": "reaction_10693245", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10725879": { "compartment": "compartment_876", "id": "reaction_10725879", "reactome": "R-DDI-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530" ], "products": [ "species_10725877" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10723407": { "compartment": "compartment_876", "id": "reaction_10723407", "reactome": "R-DDI-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723395" ], "products": [ "species_10723405" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049" ] }, "reaction_10723412": { "compartment": "compartment_876", "id": "reaction_10723412", "reactome": "R-DDI-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723395" ], "products": [ "species_10683530", "species_29420" ], "modifiers": [ [ "species_10723409", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "Q54F64", "DDB_G0291085", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q54B37", "DDB_G0293978", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10723417": { "compartment": "compartment_876", "id": "reaction_10723417", "reactome": "R-DDI-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530", "species_29356" ], "products": [ "species_10723395", "species_29372" ], "modifiers": [ [ "species_10723414", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10709853": { "compartment": "compartment_7660", "id": "reaction_10709853", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709849", "species_10709820" ], "products": [ "species_10709824" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709818": { "compartment": "compartment_7660", "id": "reaction_10709818", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706016", "species_10706025", "species_10706023", "species_10709816" ], "products": [ "species_10706029" ], "modifiers": [], "additional_components": [ "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709827": { "compartment": "compartment_7660", "id": "reaction_10709827", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709824" ], "products": [ "species_113582", "species_10705998" ], "modifiers": [ [ "species_10709824", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10706007": { "compartment": "compartment_7660", "id": "reaction_10706007", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10706000" ], "products": [ "species_113582", "species_10706004" ], "modifiers": [ [ "species_10706000", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709842": { "compartment": "compartment_7660", "id": "reaction_10709842", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709792" ], "products": [ "species_10709816" ], "modifiers": [ [ "species_10709839", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q556S0", "DDB_G0273125", "Q55DD6", "DDB_G0269692" ] }, "reaction_10706034": { "compartment": "compartment_7660", "id": "reaction_10706034", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10706029" ], "products": [ "species_113541", "species_10706031" ], "modifiers": [ [ "species_10706029", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709795": { "compartment": "compartment_7660", "id": "reaction_10709795", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706004" ], "products": [ "species_10709792" ], "modifiers": [ [ "species_10706004", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10695511": { "compartment": "compartment_70101", "id": "reaction_10695511", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10695509" ], "products": [ "species_29370", "species_10683624", "species_10685605" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10695587": { "compartment": "compartment_70101", "id": "reaction_10695587", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693765", "species_10695583" ], "products": [ "species_10695585" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102" ] }, "reaction_10696677": { "compartment": "compartment_70101", "id": "reaction_10696677", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695585" ], "products": [ "species_10695631", "species_10695581" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "species_179838", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519" ] }, "reaction_10695513": { "compartment": "compartment_70101", "id": "reaction_10695513", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683631" ], "products": [ "species_10683629", "species_10695509" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10695633": { "compartment": "compartment_70101", "id": "reaction_10695633", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680919", "species_10695631" ], "products": [ "species_10693810" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q553U6", "DDB_G0275023", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102" ] }, "reaction_10721256": { "compartment": "compartment_70101", "id": "reaction_10721256", "reactome": "R-DDI-8932243", "name": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676998", "species_71284" ], "products": [ "species_71285", "species_10721248" ], "modifiers": [ [ "species_10721253", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0277003" ] }, "reaction_10721245": { "compartment": "compartment_7660", "id": "reaction_10721245", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10672551" ], "products": [ "species_10721237", "species_77502" ], "modifiers": [ [ "species_10721242", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10721301": { "compartment": "compartment_70101", "id": "reaction_10721301", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_10721293", "species_71285" ], "modifiers": [ [ "species_10721298", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0278427" ] }, "reaction_10721279": { "compartment": "compartment_70101", "id": "reaction_10721279", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_71284" ], "products": [ "species_10721267", "species_71285" ], "modifiers": [ [ "species_10721276", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10721214": { "compartment": "compartment_70101", "id": "reaction_10721214", "reactome": "R-DDI-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10673088" ], "products": [ "species_71285", "species_10721209" ], "modifiers": [ [ "species_10721211", "catalyst" ] ], "additional_components": [ "DDB_G0293742", "DDB_G0293742", "DDB_G0291556" ] }, "reaction_10721234": { "compartment": "compartment_70101", "id": "reaction_10721234", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_71285", "species_10721226" ], "modifiers": [ [ "species_10721231", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10679876": { "compartment": "compartment_70101", "id": "reaction_10679876", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644", "species_29368" ], "products": [ "species_29366", "species_194735", "species_29356" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679891": { "compartment": "compartment_13231", "id": "reaction_10679891", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194688", "species_194725" ], "products": [ "species_194704", "species_194668" ], "modifiers": [ [ "species_10679888", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10679622": { "compartment": "compartment_70101", "id": "reaction_10679622", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_191265", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679843": { "compartment": "compartment_17951", "id": "reaction_10679843", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10725944": { "compartment": "compartment_70101", "id": "reaction_10725944", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10718908": { "compartment": "compartment_70101", "id": "reaction_10718908", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10718905", "catalyst" ] ], "additional_components": [ "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q54QP6", "DDB_G0283709", "Q54ID7", "DDB_G0288817", "Q86HV4", "DDB_G0276427" ] }, "reaction_10679883": { "compartment": "compartment_70101", "id": "reaction_10679883", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194723", "species_29368" ], "products": [ "species_29366", "species_29356", "species_194657" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679552": { "compartment": "compartment_70101", "id": "reaction_10679552", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191269", "species_29368" ], "products": [ "species_29366", "species_191309", "species_29356" ], "modifiers": [ [ "species_10679549", "catalyst" ] ], "additional_components": [ "Q54BK7", "DDB_G0293584", "species_113596" ] }, "reaction_10679863": { "compartment": "compartment_70101", "id": "reaction_10679863", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679729": { "compartment": "compartment_70101", "id": "reaction_10679729", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192114", "species_29360" ], "products": [ "species_70106", "species_73473", "species_192136" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679632": { "compartment": "compartment_70101", "id": "reaction_10679632", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10679629", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10679834": { "compartment": "compartment_876", "id": "reaction_10679834", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193416", "species_113592", "species_29356" ], "products": [ "species_29370", "species_193479", "species_29372" ], "modifiers": [ [ "species_10679831", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10714962": { "compartment": "compartment_12045", "id": "reaction_10714962", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10679836": { "compartment": "compartment_17951", "id": "reaction_10679836", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679590": { "compartment": "compartment_70101", "id": "reaction_10679590", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10679587", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10679881": { "compartment": "compartment_70101", "id": "reaction_10679881", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_73473", "species_113528", "species_194667" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679839": { "compartment": "compartment_17951", "id": "reaction_10679839", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10679600": { "compartment": "compartment_70101", "id": "reaction_10679600", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10679597", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10679620": { "compartment": "compartment_70101", "id": "reaction_10679620", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_191265", "species_29364" ], "products": [ "species_29366", "species_191269", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679749": { "compartment": "compartment_17951", "id": "reaction_10679749", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679714": { "compartment": "compartment_70101", "id": "reaction_10679714", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10679711", "catalyst" ] ], "additional_components": [ "Q55D54", "DDB_G0279611", "Q55D52", "DDB_G0279611", "species_71067", "Q54WK0", "DDB_G0279611" ] }, "reaction_10681907": { "compartment": "compartment_70101", "id": "reaction_10681907", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10681904", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10679564": { "compartment": "compartment_70101", "id": "reaction_10679564", "reactome": "R-DDI-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679913": { "compartment": "compartment_70101", "id": "reaction_10679913", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_194657" ], "products": [ "species_73473", "species_70106", "species_194661", "species_113528" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679784": { "compartment": "compartment_70101", "id": "reaction_10679784", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_176626" ], "products": [ "species_70106", "species_73473", "species_193079" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679582": { "compartment": "compartment_70101", "id": "reaction_10679582", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10679579", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10686933": { "compartment": "compartment_70101", "id": "reaction_10686933", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193066" ], "products": [ "species_29366", "species_193132" ], "modifiers": [ [ "species_10686930", "catalyst" ] ], "additional_components": [ "Q54WA9", "DDB_G0279783" ] }, "reaction_10679739": { "compartment": "compartment_17951", "id": "reaction_10679739", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10701893": { "compartment": "compartment_17957", "id": "reaction_10701893", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10701890", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10679567": { "compartment": "compartment_70101", "id": "reaction_10679567", "reactome": "R-DDI-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679871": { "compartment": "compartment_876", "id": "reaction_10679871", "reactome": "R-DDI-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "DDB_G0285165" ] }, "reaction_10679770": { "compartment": "compartment_70101", "id": "reaction_10679770", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10726092": { "compartment": "compartment_70101", "id": "reaction_10726092", "reactome": "R-DDI-9717830", "name": "GGPS1 hexamer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679782": { "compartment": "compartment_70101", "id": "reaction_10679782", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10679779", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10679928": { "compartment": "compartment_70101", "id": "reaction_10679928", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196366" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679841": { "compartment": "compartment_17951", "id": "reaction_10679841", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10726095": { "compartment": "compartment_70101", "id": "reaction_10726095", "reactome": "R-DDI-9717834", "name": "GGPS1 hexamer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679861": { "compartment": "compartment_70101", "id": "reaction_10679861", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192194", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193835" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679911": { "compartment": "compartment_70101", "id": "reaction_10679911", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644" ], "products": [ "species_29366", "species_194633" ], "modifiers": [ [ "species_10679908", "catalyst" ] ], "additional_components": [ "Q54PP1", "DDB_G0284407", "Q55GJ9", "DDB_G0267448" ] }, "reaction_10679572": { "compartment": "compartment_70101", "id": "reaction_10679572", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10679569", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10679610": { "compartment": "compartment_70101", "id": "reaction_10679610", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10679607", "catalyst" ] ], "additional_components": [ "species_29926", "Q9NH02", "DDB_G0290011" ] }, "reaction_10679899": { "compartment": "compartment_70101", "id": "reaction_10679899", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634", "species_29368" ], "products": [ "species_29366", "species_194644", "species_29460", "species_29356" ], "modifiers": [ [ "species_10679896", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10722153": { "compartment": "compartment_70101", "id": "reaction_10722153", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10722150", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10679926": { "compartment": "compartment_70101", "id": "reaction_10679926", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196344" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679859": { "compartment": "compartment_70101", "id": "reaction_10679859", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193724" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10673670": { "compartment": "compartment_70101", "id": "reaction_10673670", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673388" ], "products": [ "species_10673296", "species_10673386", "species_29420" ], "modifiers": [ [ "species_10673386", "catalyst" ] ], "additional_components": [ "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961" ] }, "reaction_10673390": { "compartment": "compartment_70101", "id": "reaction_10673390", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673338", "species_10673386" ], "products": [ "species_10673388" ], "modifiers": [], "additional_components": [ "species_29420", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862" ] }, "reaction_10712164": { "compartment": "compartment_7660", "id": "reaction_10712164", "reactome": "R-DDI-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712158" ], "products": [ "species_113582", "species_10712162" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0293750", "DDB_G0293750", "DDB_G0275845" ] }, "reaction_10714907": { "compartment": "compartment_7660", "id": "reaction_10714907", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714903", "species_10676372" ], "products": [ "species_10714905" ], "modifiers": [], "additional_components": [ "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54G78", "DDB_G0290331" ] }, "reaction_10700599": { "compartment": "compartment_7660", "id": "reaction_10700599", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698368", "species_10700571" ], "products": [ "species_10698305", "species_10700596" ], "modifiers": [ [ "species_10698368", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0268098", "DDB_G0287693", "DDB_G0268098", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700587": { "compartment": "compartment_7660", "id": "reaction_10700587", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700571" ], "products": [ "species_10698305", "species_10700585" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268098", "DDB_G0287693", "Q55FI4", "DDB_G0268098", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676662": { "compartment": "compartment_114521", "id": "reaction_10676662", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676659", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10676758": { "compartment": "compartment_876", "id": "reaction_10676758", "reactome": "R-DDI-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676755", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10692427": { "compartment": "compartment_161320", "id": "reaction_10692427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692508": { "compartment": "compartment_876", "id": "reaction_10692508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10692505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10692400": { "compartment": "compartment_161320", "id": "reaction_10692400", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10692397", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10693818": { "compartment": "compartment_876", "id": "reaction_10693818", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10693815", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10692360": { "compartment": "compartment_161320", "id": "reaction_10692360", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692425": { "compartment": "compartment_161320", "id": "reaction_10692425", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10692422", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10692437": { "compartment": "compartment_876", "id": "reaction_10692437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29356" ], "products": [ "species_1861754", "species_1606609" ], "modifiers": [ [ "species_10692434", "catalyst" ] ], "additional_components": [ "Q54BK2", "DDB_G0293538" ] }, "reaction_10692417": { "compartment": "compartment_161320", "id": "reaction_10692417", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10692414", "catalyst" ] ], "additional_components": [ "Q55B10", "DDB_G0271490", "Q54EG4", "DDB_G0291524" ] }, "reaction_10702402": { "compartment": "compartment_876", "id": "reaction_10702402", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684166", "species_10684155" ], "products": [ "species_10702400" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q55CT1", "DDB_G0269912", "Q54PE8", "DDB_G0289473", "Q54L96", "DDB_G0286763" ] }, "reaction_10688485": { "compartment": "compartment_74700", "id": "reaction_10688485", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688478", "species_10685814" ], "products": [ "species_10688480" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688006": { "compartment": "compartment_70101", "id": "reaction_10688006", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687994", "species_10685814" ], "products": [ "species_10687996" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688483": { "compartment": "compartment_74700", "id": "reaction_10688483", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10688480" ], "products": [ "species_10686011" ], "modifiers": [ [ "species_10688480", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10678168": { "compartment": "compartment_984", "id": "reaction_10678168", "reactome": "R-DDI-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678162", "species_168948" ], "products": [ "species_10678166" ], "modifiers": [], "additional_components": [ "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628", "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628" ] }, "reaction_10719248": { "compartment": "compartment_984", "id": "reaction_10719248", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10677632" ], "products": [ "species_10719246" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_2186967" ] }, "reaction_10688009": { "compartment": "compartment_70101", "id": "reaction_10688009", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10688001", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10677638": { "compartment": "compartment_984", "id": "reaction_10677638", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677632", "species_166005" ], "products": [ "species_10677634" ], "modifiers": [ [ "species_10677636", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_6803081", "DDB_G0271242" ] }, "reaction_10714923": { "compartment": "compartment_984", "id": "reaction_10714923", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340" ], "products": [ "species_10714865" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10688004": { "compartment": "compartment_876", "id": "reaction_10688004", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10687996" ], "products": [ "species_10688001" ], "modifiers": [ [ "species_10687996", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10714873": { "compartment": "compartment_984", "id": "reaction_10714873", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_166005" ], "products": [ "species_10714871" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_6803081" ] }, "reaction_10714869": { "compartment": "compartment_984", "id": "reaction_10714869", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_181015" ], "products": [ "species_10714867" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10704731": { "compartment": "compartment_70101", "id": "reaction_10704731", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10704728", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10726173": { "compartment": "compartment_70101", "id": "reaction_10726173", "reactome": "R-DDI-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10726170", "catalyst" ] ], "additional_components": [ "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10726136": { "compartment": "compartment_70101", "id": "reaction_10726136", "reactome": "R-DDI-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726125": { "compartment": "compartment_70101", "id": "reaction_10726125", "reactome": "R-DDI-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10726122", "catalyst" ] ], "additional_components": [ "P32073", "DDB_G0281551" ] }, "reaction_10726134": { "compartment": "compartment_70101", "id": "reaction_10726134", "reactome": "R-DDI-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10678993", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10726163": { "compartment": "compartment_70101", "id": "reaction_10726163", "reactome": "R-DDI-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726129": { "compartment": "compartment_70101", "id": "reaction_10726129", "reactome": "R-DDI-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726118": { "compartment": "compartment_70101", "id": "reaction_10726118", "reactome": "R-DDI-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10674001", "catalyst" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701" ] }, "reaction_10726127": { "compartment": "compartment_70101", "id": "reaction_10726127", "reactome": "R-DDI-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10726131": { "compartment": "compartment_70101", "id": "reaction_10726131", "reactome": "R-DDI-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10726120": { "compartment": "compartment_70101", "id": "reaction_10726120", "reactome": "R-DDI-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10678801": { "compartment": "compartment_7660", "id": "reaction_10678801", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647" ], "products": [ "species_10678645", "species_10678597" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259" ] }, "reaction_10678652": { "compartment": "compartment_7660", "id": "reaction_10678652", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647", "species_10669917" ], "products": [ "species_10678649" ], "modifiers": [ [ "species_10678647", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678780": { "compartment": "compartment_70101", "id": "reaction_10678780", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678775" ], "products": [ "species_10678777" ], "modifiers": [ [ "species_10676850", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q8T2F2", "DDB_G0277439", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678754": { "compartment": "compartment_7660", "id": "reaction_10678754", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678741": { "compartment": "compartment_7660", "id": "reaction_10678741", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678649" ], "products": [ "species_10678645", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678784": { "compartment": "compartment_70101", "id": "reaction_10678784", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678782" ], "products": [ "species_10670153", "species_10670512" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679249": { "compartment": "compartment_7660", "id": "reaction_10679249", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10679167": { "compartment": "compartment_70101", "id": "reaction_10679167", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10679160" ], "products": [ "species_10679164" ], "modifiers": [ [ "species_10679160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676858": { "compartment": "compartment_70101", "id": "reaction_10676858", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676836", "species_10676831", "species_10676841", "species_10676846" ], "products": [ "species_10676848" ], "modifiers": [], "additional_components": [ "DDB_G0292134", "DDB_G0292676", "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10679169": { "compartment": "compartment_70101", "id": "reaction_10679169", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679164" ], "products": [ "species_10670153", "species_10676850" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678858": { "compartment": "compartment_70101", "id": "reaction_10678858", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678844" ], "products": [ "species_10678856", "species_10670153", "species_10678838" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54MZ3", "DDB_G0285601", "Q54KM3", "DDB_G0287259", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678769": { "compartment": "compartment_70101", "id": "reaction_10678769", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670512", "species_10678765" ], "products": [ "species_10678767" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q86HN7", "DDB_G0274503", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678852": { "compartment": "compartment_70101", "id": "reaction_10678852", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678767" ], "products": [ "species_10678782" ], "modifiers": [ [ "species_10678767", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678854": { "compartment": "compartment_70101", "id": "reaction_10678854", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678809" ], "products": [ "species_10670153", "species_10678797" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679162": { "compartment": "compartment_70101", "id": "reaction_10679162", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850", "species_10679158" ], "products": [ "species_10679160" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0270814", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676852": { "compartment": "compartment_70101", "id": "reaction_10676852", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676848", "species_10670505" ], "products": [ "species_10676850" ], "modifiers": [], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678862": { "compartment": "compartment_70101", "id": "reaction_10678862", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679243" ], "products": [ "species_10678747", "species_10670680", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0290551", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678812": { "compartment": "compartment_70101", "id": "reaction_10678812", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678805" ], "products": [ "species_10678809" ], "modifiers": [ [ "species_10678797", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676856": { "compartment": "compartment_70101", "id": "reaction_10676856", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676841", "species_10676846" ], "products": [ "species_10676854" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201" ] }, "reaction_10678868": { "compartment": "compartment_70101", "id": "reaction_10678868", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850" ], "products": [ "species_10678797", "species_10678866" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10725854": { "compartment": "compartment_7660", "id": "reaction_10725854", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725851", "species_10669917" ], "products": [ "species_10679243" ], "modifiers": [ [ "species_10725851", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678795": { "compartment": "compartment_7660", "id": "reaction_10678795", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678645" ], "products": [ "species_10678645" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0274503" ] }, "reaction_10678847": { "compartment": "compartment_70101", "id": "reaction_10678847", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678842" ], "products": [ "species_10678844" ], "modifiers": [ [ "species_10678838", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10693242": { "compartment": "compartment_172574", "id": "reaction_10693242", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691994": { "compartment": "compartment_12045", "id": "reaction_10691994", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10691991", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54WR4", "DDB_G0279483" ] }, "reaction_10691844": { "compartment": "compartment_12045", "id": "reaction_10691844", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10691841", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691704": { "compartment": "compartment_12045", "id": "reaction_10691704", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10716710": { "compartment": "compartment_876", "id": "reaction_10716710", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10716707", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10691923": { "compartment": "compartment_12045", "id": "reaction_10691923", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10691920", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10691709": { "compartment": "compartment_12045", "id": "reaction_10691709", "reactome": "R-DDI-1482696", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691773": { "compartment": "compartment_12045", "id": "reaction_10691773", "reactome": "R-DDI-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691770", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693140": { "compartment": "compartment_876", "id": "reaction_10693140", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10710251": { "compartment": "compartment_876", "id": "reaction_10710251", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10710248", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10693123": { "compartment": "compartment_171062", "id": "reaction_10693123", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693332": { "compartment": "compartment_20699", "id": "reaction_10693332", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10693329", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10693135": { "compartment": "compartment_876", "id": "reaction_10693135", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10693132", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927" ] }, "reaction_10691817": { "compartment": "compartment_12045", "id": "reaction_10691817", "reactome": "R-DDI-1482920", "name": "PG is hydrolyzed to 2-acyl LPG by PLA2[14]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498730", "species_1524021" ], "modifiers": [ [ "species_10691814", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691802": { "compartment": "compartment_12045", "id": "reaction_10691802", "reactome": "R-DDI-1482892", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691812": { "compartment": "compartment_12045", "id": "reaction_10691812", "reactome": "R-DDI-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498740", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691805": { "compartment": "compartment_70616", "id": "reaction_10691805", "reactome": "R-DDI-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1498773", "species_1524083" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691683": { "compartment": "compartment_12045", "id": "reaction_10691683", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10691907": { "compartment": "compartment_70101", "id": "reaction_10691907", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10691904", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10693310": { "compartment": "compartment_20699", "id": "reaction_10693310", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10693137": { "compartment": "compartment_20699", "id": "reaction_10693137", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693277": { "compartment": "compartment_20699", "id": "reaction_10693277", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10717024": { "compartment": "compartment_70101", "id": "reaction_10717024", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10717021", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_1806205", "species_6810408", "species_1806159", "Q54FY6", "DDB_G0290653", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630" ] }, "reaction_10716932": { "compartment": "compartment_12045", "id": "reaction_10716932", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10716927", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10691872": { "compartment": "compartment_20699", "id": "reaction_10691872", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10691869", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691789": { "compartment": "compartment_12045", "id": "reaction_10691789", "reactome": "R-DDI-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693250": { "compartment": "compartment_171062", "id": "reaction_10693250", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10710279": { "compartment": "compartment_70101", "id": "reaction_10710279", "reactome": "R-DDI-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10710276", "catalyst" ] ], "additional_components": [ "Q54QE7", "DDB_G0291476", "Q54EK1", "DDB_G0291476" ] }, "reaction_10691810": { "compartment": "compartment_12045", "id": "reaction_10691810", "reactome": "R-DDI-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10691807", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691822": { "compartment": "compartment_12045", "id": "reaction_10691822", "reactome": "R-DDI-1482932", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498737", "species_1524021" ], "modifiers": [ [ "species_10691819", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10674942": { "compartment": "compartment_12045", "id": "reaction_10674942", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10674939", "catalyst" ] ], "additional_components": [ "Q54EU4", "DDB_G0291332", "Q54IG1", "DDB_G0288863", "Q554U0", "DDB_G0274969", "Q54IT8", "DDB_G0288523" ] }, "reaction_10691795": { "compartment": "compartment_12045", "id": "reaction_10691795", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691755", "catalyst" ] ], "additional_components": [ "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691697": { "compartment": "compartment_12045", "id": "reaction_10691697", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691999": { "compartment": "compartment_12045", "id": "reaction_10691999", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10691996", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10715867": { "compartment": "compartment_70101", "id": "reaction_10715867", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693218", "species_10715851" ], "products": [ "species_10715865" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693285": { "compartment": "compartment_20699", "id": "reaction_10693285", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10692026": { "compartment": "compartment_20699", "id": "reaction_10692026", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691932" ], "products": [ "species_10692024" ], "modifiers": [], "additional_components": [ "species_426925", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10691650": { "compartment": "compartment_12045", "id": "reaction_10691650", "reactome": "R-DDI-1482571", "name": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693112": { "compartment": "compartment_20699", "id": "reaction_10693112", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10693109", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10691800": { "compartment": "compartment_12045", "id": "reaction_10691800", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10691797", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10693081": { "compartment": "compartment_20699", "id": "reaction_10693081", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10693078", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691743": { "compartment": "compartment_70616", "id": "reaction_10691743", "reactome": "R-DDI-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524079", "species_1524072" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691957": { "compartment": "compartment_70616", "id": "reaction_10691957", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10691954", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10692991": { "compartment": "compartment_20699", "id": "reaction_10692991", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10692988", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10691692": { "compartment": "compartment_12045", "id": "reaction_10691692", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692777": { "compartment": "compartment_876", "id": "reaction_10692777", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691648": { "compartment": "compartment_17906", "id": "reaction_10691648", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10691645", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10691934": { "compartment": "compartment_20699", "id": "reaction_10691934", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10691930" ], "products": [ "species_1524146", "species_10691932" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10686815": { "compartment": "compartment_12045", "id": "reaction_10686815", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10674935", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10693288": { "compartment": "compartment_876", "id": "reaction_10693288", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691685": { "compartment": "compartment_12045", "id": "reaction_10691685", "reactome": "R-DDI-1482629", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715945": { "compartment": "compartment_70101", "id": "reaction_10715945", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693303": { "compartment": "compartment_20699", "id": "reaction_10693303", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693076", "species_10693301" ], "products": [ "species_10693078" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "DDB_G0286479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691776": { "compartment": "compartment_70616", "id": "reaction_10691776", "reactome": "R-DDI-1482847", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524047" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691707": { "compartment": "compartment_12045", "id": "reaction_10691707", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10718992": { "compartment": "compartment_12045", "id": "reaction_10718992", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10718989", "catalyst" ] ], "additional_components": [ "Q54RM1", "DDB_G0283035", "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q86HV4", "DDB_G0276427" ] }, "reaction_10691655": { "compartment": "compartment_12045", "id": "reaction_10691655", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10722413": { "compartment": "compartment_17906", "id": "reaction_10722413", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10722410", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10691666": { "compartment": "compartment_17906", "id": "reaction_10691666", "reactome": "R-DDI-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590", "species_29356" ], "products": [ "species_1524103", "species_1500580" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715912": { "compartment": "compartment_171062", "id": "reaction_10715912", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10715903", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691680": { "compartment": "compartment_12045", "id": "reaction_10691680", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715948": { "compartment": "compartment_70101", "id": "reaction_10715948", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691792": { "compartment": "compartment_12045", "id": "reaction_10691792", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710324": { "compartment": "compartment_17906", "id": "reaction_10710324", "reactome": "R-DDI-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10710321", "catalyst" ] ], "additional_components": [ "species_6797635", "species_6814795", "species_1602448", "species_417891", "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "species_29926", "Q54HN2", "DDB_G0289343" ] }, "reaction_10692978": { "compartment": "compartment_876", "id": "reaction_10692978", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10715905": { "compartment": "compartment_70101", "id": "reaction_10715905", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692890", "species_10715901" ], "products": [ "species_10715903" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721170": { "compartment": "compartment_5460", "id": "reaction_10721170", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10721167", "catalyst" ] ], "additional_components": [ "DDB_G0284755" ] }, "reaction_10691765": { "compartment": "compartment_12045", "id": "reaction_10691765", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691762", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710368": { "compartment": "compartment_12045", "id": "reaction_10710368", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680333": { "compartment": "compartment_70101", "id": "reaction_10680333", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691952": { "compartment": "compartment_12045", "id": "reaction_10691952", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10691949", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10691882": { "compartment": "compartment_12045", "id": "reaction_10691882", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10691879", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29418", "species_29926" ] }, "reaction_10685601": { "compartment": "compartment_984", "id": "reaction_10685601", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10685598", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10711099": { "compartment": "compartment_70101", "id": "reaction_10711099", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10711096", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q55DN9", "DDB_G0276935" ] }, "reaction_10691727": { "compartment": "compartment_70616", "id": "reaction_10691727", "reactome": "R-DDI-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1524085", "species_1498753" ], "modifiers": [ [ "species_10691724", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693335": { "compartment": "compartment_171062", "id": "reaction_10693335", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10693095", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693308": { "compartment": "compartment_876", "id": "reaction_10693308", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10693305", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10693296": { "compartment": "compartment_876", "id": "reaction_10693296", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693293", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693282": { "compartment": "compartment_12045", "id": "reaction_10693282", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10693279", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10693291": { "compartment": "compartment_171062", "id": "reaction_10693291", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691965": { "compartment": "compartment_12045", "id": "reaction_10691965", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_71284" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10691962", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10722158": { "compartment": "compartment_984", "id": "reaction_10722158", "reactome": "R-DDI-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10722155", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10693313": { "compartment": "compartment_876", "id": "reaction_10693313", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691699": { "compartment": "compartment_70101", "id": "reaction_10691699", "reactome": "R-DDI-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691732": { "compartment": "compartment_12045", "id": "reaction_10691732", "reactome": "R-DDI-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498724", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10720416": { "compartment": "compartment_876", "id": "reaction_10720416", "reactome": "R-DDI-8870489", "name": "PLEKHA4,(5,6) bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720412", "species_1806276" ], "products": [ "species_10720414" ], "modifiers": [], "additional_components": [ "Q54Z52", "DDB_G0277777", "Q54Z52", "DDB_G0277777", "species_1806159" ] }, "reaction_10693003": { "compartment": "compartment_876", "id": "reaction_10693003", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10719120": { "compartment": "compartment_70101", "id": "reaction_10719120", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10719117", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q55DN9", "DDB_G0276935" ] }, "reaction_10693228": { "compartment": "compartment_876", "id": "reaction_10693228", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691640": { "compartment": "compartment_12045", "id": "reaction_10691640", "reactome": "R-DDI-1482545", "name": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715942": { "compartment": "compartment_70101", "id": "reaction_10715942", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715938" ], "products": [ "species_10715940" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10682763": { "compartment": "compartment_984", "id": "reaction_10682763", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10682758", "catalyst" ], [ "species_10682761", "inhibitor" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10693239": { "compartment": "compartment_876", "id": "reaction_10693239", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10693236", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10702080": { "compartment": "compartment_876", "id": "reaction_10702080", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702076", "species_171142" ], "products": [ "species_10702078" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q86K21", "DDB_G0272875", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791", "Q86K21", "DDB_G0272875", "species_171142", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791" ] }, "reaction_10715875": { "compartment": "compartment_876", "id": "reaction_10715875", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10715909": { "compartment": "compartment_70101", "id": "reaction_10715909", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715901" ], "products": [ "species_10715907" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693299": { "compartment": "compartment_876", "id": "reaction_10693299", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691942": { "compartment": "compartment_12045", "id": "reaction_10691942", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_200736" ], "products": [ "species_1500646", "species_1498751" ], "modifiers": [ [ "species_10691939", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10692973": { "compartment": "compartment_172574", "id": "reaction_10692973", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691720": { "compartment": "compartment_70616", "id": "reaction_10691720", "reactome": "R-DDI-1482745", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524027" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10715855": { "compartment": "compartment_70101", "id": "reaction_10715855", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715851", "species_10715825" ], "products": [ "species_10715853" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691635": { "compartment": "compartment_12045", "id": "reaction_10691635", "reactome": "R-DDI-1482543", "name": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_29356" ], "products": [ "species_76116", "species_1500593" ], "modifiers": [ [ "species_10691632", "catalyst" ] ], "additional_components": [ "Q55EQ3", "DDB_G0269086" ] }, "reaction_10721177": { "compartment": "compartment_984", "id": "reaction_10721177", "reactome": "R-DDI-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878780", "species_109276" ], "products": [ "species_109277", "species_8878776" ], "modifiers": [ [ "species_10721174", "catalyst" ] ], "additional_components": [ "species_29426", "species_74016", "Q54Y02", "DDB_G0278495" ] }, "reaction_10691702": { "compartment": "compartment_12045", "id": "reaction_10691702", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692986": { "compartment": "compartment_12045", "id": "reaction_10692986", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10692049": { "compartment": "compartment_12045", "id": "reaction_10692049", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692028" ], "products": [ "species_10691930" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10693269": { "compartment": "compartment_876", "id": "reaction_10693269", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693266", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "species_29418", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10715872": { "compartment": "compartment_876", "id": "reaction_10715872", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693230": { "compartment": "compartment_172574", "id": "reaction_10693230", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10718631": { "compartment": "compartment_984", "id": "reaction_10718631", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_83910", "species_8865629" ], "modifiers": [ [ "species_10718628", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10679264": { "compartment": "compartment_5460", "id": "reaction_10679264", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10679261", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10697686": { "compartment": "compartment_1598585", "id": "reaction_10697686", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10697678", "species_10697638" ], "products": [ "species_10697684" ], "modifiers": [], "additional_components": [ "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54S35", "DDB_G0282689", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q54RK7", "DDB_G0283099", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101" ] }, "reaction_10724623": { "compartment": "compartment_984", "id": "reaction_10724623", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10709857", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q54ET7", "DDB_G0291344" ] }, "reaction_10675685": { "compartment": "compartment_7660", "id": "reaction_10675685", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675681", "species_10675662" ], "products": [ "species_10675683" ], "modifiers": [], "additional_components": [ "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10675664": { "compartment": "compartment_7660", "id": "reaction_10675664", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675660" ], "products": [ "species_10675662" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10675689": { "compartment": "compartment_7660", "id": "reaction_10675689", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675683" ], "products": [ "species_10675681", "species_10675687" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10682234": { "compartment": "compartment_70101", "id": "reaction_10682234", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10682231", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10696143": { "compartment": "compartment_70101", "id": "reaction_10696143", "reactome": "R-DDI-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10696140", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "species_29450" ] }, "reaction_10679144": { "compartment": "compartment_5460", "id": "reaction_10679144", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_177153", "species_113593" ], "products": [ "species_159448", "species_177137", "species_159450" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677098": { "compartment": "compartment_5460", "id": "reaction_10677098", "reactome": "R-DDI-159567", "name": "ACSM2B-like proteins transform ST to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159559", "species_113593" ], "products": [ "species_159448", "species_159557", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677081": { "compartment": "compartment_5460", "id": "reaction_10677081", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159446", "species_113593" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10723456": { "compartment": "compartment_70101", "id": "reaction_10723456", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723452", "species_10676533" ], "products": [ "species_10723454" ], "modifiers": [], "additional_components": [ "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q869N2", "DDB_G0276459" ] }, "reaction_10703564": { "compartment": "compartment_876", "id": "reaction_10703564", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703557" ], "products": [ "species_10703559" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10726069": { "compartment": "compartment_876", "id": "reaction_10726069", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726067" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10726063": { "compartment": "compartment_876", "id": "reaction_10726063", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726050" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10703562": { "compartment": "compartment_70101", "id": "reaction_10703562", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703559", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10723450": { "compartment": "compartment_70101", "id": "reaction_10723450", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723366", "species_10723444" ], "products": [ "species_10723448" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723813": { "compartment": "compartment_876", "id": "reaction_10723813", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723796", "species_10723809" ], "products": [ "species_10723811" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q55CB3", "DDB_G0290593", "Q86KL1", "DDB_G0274241", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q54LT3", "DDB_G0286425", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q54FU0", "DDB_G0290593", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q54B82", "DDB_G0293844", "P34144", "DDB_G0277869", "P34146", "DDB_G0282365", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q86KL1", "DDB_G0274241", "species_29438", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "Q54HL6", "DDB_G0289361", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593" ] }, "reaction_10723162": { "compartment": "compartment_876", "id": "reaction_10723162", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10723159", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54PB7", "DDB_G0292004", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54DS6", "DDB_G0291974", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q55BQ8", "DDB_G0292004", "Q54S15", "DDB_G0293396", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q54DW1", "DDB_G0292004", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10725982": { "compartment": "compartment_263163", "id": "reaction_10725982", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725978", "species_10725976" ], "products": [ "species_10725980" ], "modifiers": [], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q8T2F2", "DDB_G0277439", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "P36411", "DDB_G0269236", "Q1ZXI1", "DDB_G0279085", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54NZ5", "DDB_G0284903", "Q54FK7", "DDB_G0290779", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "Q54FK8", "DDB_G0290829", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q1ZXB9", "DDB_G0290831", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "P34145", "DDB_G0268622", "Q1ZXI1", "DDB_G0279085", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P34146", "DDB_G0282365", "Q8T2F2", "DDB_G0277439", "Q54K69", "DDB_G0287553", "Q9GPR7", "DDB_G0269240", "Q54FK2", "DDB_G0290793", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q54FK5", "DDB_G0290789", "species_113592", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975" ] }, "reaction_10723744": { "compartment": "compartment_876", "id": "reaction_10723744", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723740", "species_10723682" ], "products": [ "species_10723742" ], "modifiers": [], "additional_components": [ "Q55CB2", "DDB_G0290593", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q54P92", "DDB_G0284699", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "Q54TA6", "DDB_G0281889", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q54P92", "DDB_G0284699", "P34150", "DDB_G0291976", "Q8MPQ7", "DDB_G0280053", "Q54N82", "DDB_G0285453", "Q86HL8", "DDB_G0274517", "P34145", "DDB_G0268622", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "P34146", "DDB_G0282365", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q54TA6", "DDB_G0281889", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "P34149", "DDB_G0293526", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459" ] }, "reaction_10723589": { "compartment": "compartment_876", "id": "reaction_10723589", "reactome": "R-DDI-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723581" ], "products": [ "species_10723579", "species_29420" ], "modifiers": [ [ "species_10689591", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084" ] }, "reaction_10702646": { "compartment": "compartment_876", "id": "reaction_10702646", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10680761" ], "products": [ "species_10702641" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10725989": { "compartment": "compartment_263163", "id": "reaction_10725989", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725976", "species_29356" ], "products": [ "species_10725986", "species_29372" ], "modifiers": [ [ "species_10725976", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "species_29370", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10726061": { "compartment": "compartment_17906", "id": "reaction_10726061", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726050", "species_10726057" ], "products": [ "species_10726059" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55DS3", "DDB_G0269550", "Q55DS3", "DDB_G0269550", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10702637": { "compartment": "compartment_70101", "id": "reaction_10702637", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10702633" ], "products": [ "species_10702635" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723890": { "compartment": "compartment_876", "id": "reaction_10723890", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723880" ], "products": [ "species_10723878", "species_29372" ], "modifiers": [ [ "species_10723887", "catalyst" ] ], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "species_29420", "P34147", "DDB_G0286555", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q8I7P3", "DDB_G0267462", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10723688": { "compartment": "compartment_876", "id": "reaction_10723688", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723680", "species_29438" ], "products": [ "species_10723682" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723759": { "compartment": "compartment_876", "id": "reaction_10723759", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723748", "species_10723755" ], "products": [ "species_10723757" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "species_29438", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10712144": { "compartment": "compartment_1222693", "id": "reaction_10712144", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10712141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10722712": { "compartment": "compartment_70101", "id": "reaction_10722712", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683656" ], "products": [ "species_10683654", "species_10702660" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10726075": { "compartment": "compartment_876", "id": "reaction_10726075", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723880" ], "products": [ "species_10726073" ], "modifiers": [], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10723466": { "compartment": "compartment_70101", "id": "reaction_10723466", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723444" ], "products": [ "species_10676533", "species_29420" ], "modifiers": [ [ "species_10723463", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084", "Q54LN3", "DDB_G0286543", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10674723": { "compartment": "compartment_70101", "id": "reaction_10674723", "reactome": "R-DDI-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674719", "species_10674690" ], "products": [ "species_10674721" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "DDB_G0283617", "P54632", "DDB_G0269138", "Q54QM6", "DDB_G0283617" ] }, "reaction_10723374": { "compartment": "compartment_876", "id": "reaction_10723374", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723370", "species_10695507" ], "products": [ "species_10723372" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "P34144", "DDB_G0277869", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34144", "DDB_G0277869" ] }, "reaction_10723874": { "compartment": "compartment_876", "id": "reaction_10723874", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723872" ], "products": [ "species_10723864", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10703581": { "compartment": "compartment_70101", "id": "reaction_10703581", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703572" ], "products": [ "species_29370", "species_10703578" ], "modifiers": [ [ "species_10702680", "catalyst" ] ], "additional_components": [ "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10703534": { "compartment": "compartment_876", "id": "reaction_10703534", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703530" ], "products": [ "species_10703532" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10725984": { "compartment": "compartment_263163", "id": "reaction_10725984", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10725974" ], "products": [ "species_10725976" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10723906": { "compartment": "compartment_876", "id": "reaction_10723906", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723902", "species_10723880" ], "products": [ "species_10723904" ], "modifiers": [], "additional_components": [ "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "P34147", "DDB_G0286555", "species_29438", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "P34147", "DDB_G0286555", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "species_29438", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10723586": { "compartment": "compartment_876", "id": "reaction_10723586", "reactome": "R-DDI-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723579", "species_29356" ], "products": [ "species_10723581", "species_29372" ], "modifiers": [ [ "species_10723583", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q8I7P3", "DDB_G0267462", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10726106": { "compartment": "compartment_876", "id": "reaction_10726106", "reactome": "R-DDI-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726100" ], "products": [ "species_10726104" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723461": { "compartment": "compartment_70101", "id": "reaction_10723461", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533", "species_29356" ], "products": [ "species_10723444", "species_29372" ], "modifiers": [ [ "species_10723458", "catalyst" ] ], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q9GPQ8", "DDB_G0292816", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723354": { "compartment": "compartment_876", "id": "reaction_10723354", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10723350" ], "products": [ "species_10723352" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "species_29438", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10702689": { "compartment": "compartment_70101", "id": "reaction_10702689", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702662", "species_113592" ], "products": [ "species_29370", "species_10683624", "species_10702686" ], "modifiers": [ [ "species_10702662", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723870": { "compartment": "compartment_876", "id": "reaction_10723870", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723864", "species_10723866" ], "products": [ "species_10723868" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "species_29438", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459" ] }, "reaction_10702643": { "compartment": "compartment_70101", "id": "reaction_10702643", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10693765" ], "products": [ "species_10702639" ], "modifiers": [ [ "species_10702641", "inhibitor" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q54K32", "DDB_G0287585", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "species_29438", "O00899", "DDB_G0269140", "Q54HF1", "DDB_G0289505", "Q9GPS0", "DDB_G0269178", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "P34144", "DDB_G0277869", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723898": { "compartment": "compartment_876", "id": "reaction_10723898", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_10723892" ], "products": [ "species_10723896" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "Q95UQ1", "DDB_G0291077", "species_29420", "Q95UQ1", "DDB_G0291077", "P34147", "DDB_G0286555" ] }, "reaction_10723798": { "compartment": "compartment_74700", "id": "reaction_10723798", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723794" ], "products": [ "species_10723796" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10703537": { "compartment": "compartment_70101", "id": "reaction_10703537", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703532", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10723885": { "compartment": "compartment_876", "id": "reaction_10723885", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_29438" ], "products": [ "species_10723880", "species_29420" ], "modifiers": [ [ "species_10723882", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084" ] }, "reaction_10723290": { "compartment": "compartment_876", "id": "reaction_10723290", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_29356" ], "products": [ "species_29372", "species_10695507" ], "modifiers": [ [ "species_10723287", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54FG5", "DDB_G0290873", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10725875": { "compartment": "compartment_876", "id": "reaction_10725875", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526" ], "products": [ "species_10725873" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10722714": { "compartment": "compartment_70101", "id": "reaction_10722714", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683652" ], "products": [ "species_10683650", "species_10702658" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723764": { "compartment": "compartment_876", "id": "reaction_10723764", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723761" ], "products": [ "species_10723748", "species_29420" ], "modifiers": [ [ "species_10723761", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723468": { "compartment": "compartment_876", "id": "reaction_10723468", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10703511" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723686": { "compartment": "compartment_876", "id": "reaction_10723686", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723682" ], "products": [ "species_10723684" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q95UQ1", "DDB_G0291077", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "Q95UP9", "DDB_G0280049", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723860": { "compartment": "compartment_74700", "id": "reaction_10723860", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723845", "species_10723856" ], "products": [ "species_10723858" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54Y26", "DDB_G0278457", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q869T1", "DDB_G0274437", "Q54HF1", "DDB_G0289505", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P34146", "DDB_G0282365", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q869T1", "DDB_G0274437", "P34148", "DDB_G0279605", "Q54HF1", "DDB_G0289505", "P34149", "DDB_G0293526", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530" ] }, "reaction_10682167": { "compartment": "compartment_13231", "id": "reaction_10682167", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682163" ], "products": [ "species_10682165" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10682358": { "compartment": "compartment_7660", "id": "reaction_10682358", "reactome": "R-DDI-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10682348" ], "products": [ "species_113582", "species_10682163" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0288453", "DDB_G0288453", "DDB_G0275845" ] }, "reaction_10682172": { "compartment": "compartment_70101", "id": "reaction_10682172", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10682165" ], "products": [ "species_10682169" ], "modifiers": [ [ "species_10682165", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453" ] }, "reaction_10682174": { "compartment": "compartment_70101", "id": "reaction_10682174", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682169" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10684699": { "compartment": "compartment_7660", "id": "reaction_10684699", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684682", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10682100" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10684702": { "compartment": "compartment_7660", "id": "reaction_10684702", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10682100" ], "products": [ "species_10674676", "species_77502" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10689258": { "compartment": "compartment_70101", "id": "reaction_10689258", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689251" ], "products": [ "species_10689255", "species_10689247", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689128", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54YW2", "DDB_G0278049", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q54FX4", "DDB_G0290547", "Q550Z9", "DDB_G0276695", "Q54LZ6", "DDB_G0286289", "Q94490", "DDB_G0284865", "Q55EJ5", "DDB_G0270000", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54XF1", "DDB_G0279003", "Q54L05", "DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", 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"DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q557I6", "DDB_G0273399", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q75JS0", "DDB_G0272202", "Q557E7", "DDB_G0273141", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249" ] }, "reaction_10689274": { "compartment": "compartment_70101", "id": "reaction_10689274", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10670153", "species_983032", "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689362": { "compartment": "compartment_70101", "id": "reaction_10689362", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10689359", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10721580": { "compartment": "compartment_70101", "id": "reaction_10721580", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10721577", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10681335": { "compartment": "compartment_12045", "id": "reaction_10681335", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681331" ], "products": [ "species_10681333" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29438", "Q559R0", "DDB_G0272296" ] }, "reaction_10689306": { "compartment": "compartment_70101", "id": "reaction_10689306", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_29926", "species_10689298" ], "products": [ "species_10689300", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10689298", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047" ] }, "reaction_10689303": { "compartment": "compartment_70101", "id": "reaction_10689303", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689300", "species_10689247" ], "products": [ "species_10689249", "species_10689298" ], "modifiers": [ [ "species_10689247", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345" ] }, "reaction_10689341": { "compartment": "compartment_17957", "id": "reaction_10689341", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10689338", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10689309": { "compartment": "compartment_70101", "id": "reaction_10689309", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689255", "species_113592" ], "products": [ "species_10689247", "species_10689270", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689255", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689128", "species_983035" ], "products": [ "species_10689251" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", 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"DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54E43", "DDB_G0291812", "Q54TE1", "DDB_G0290629", "Q54JT8", "DDB_G0292128", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q55C16", "DDB_G0270272", "Q557I6", "DDB_G0273399", "Q54D06", "DDB_G0292596", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "P0CG80", "DDB_G0291928", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "Q75JS0", "DDB_G0272202", "P14794", "DDB_G0280755", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q553F3", "DDB_G0275787", "Q557Q0", "DDB_G0291812", "Q75JE1", "DDB_G0288345", "Q54XF7", "DDB_G0278991", "Q54TL7", "DDB_G0281679", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54JV0", "DDB_G0292128", "Q54I43", "DDB_G0289021", "Q54I29", "DDB_G0292642", "Q54IK3", "DDB_G0290547", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54RP0", "DDB_G0283005", "Q54VG3", "DDB_G0280347", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q54VW9", "DDB_G0280091", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "P0CG79", "DDB_G0282369", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54U33", "DDB_G0281369", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "P0CG77", "DDB_G0286907", "Q55EY8", "DDB_G0268938", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q54TK0", "DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q555G0", "DDB_G0274897", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q54J27", "DDB_G0288345" ] }, "reaction_10689272": { "compartment": "compartment_70101", "id": "reaction_10689272", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689270" ], "products": [ "species_983123", "species_10689128" ], "modifiers": [], "additional_components": [ "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10722775": { "compartment": "compartment_876", "id": "reaction_10722775", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722754" ], "products": [ "species_10722772", "species_29372" ], "modifiers": [ [ "species_10722754", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684253": { "compartment": "compartment_876", "id": "reaction_10684253", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141" ], "products": [ "species_10684218" ], "modifiers": [ [ "species_10676141", "catalyst" ], [ "species_10684251", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10676760": { "compartment": "compartment_70101", "id": "reaction_10676760", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676657", "species_114520" ], "products": [ "species_10676659" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10684674": { "compartment": "compartment_70101", "id": "reaction_10684674", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10684665", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10722756": { "compartment": "compartment_876", "id": "reaction_10722756", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_10722752" ], "products": [ "species_10722754" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684660": { "compartment": "compartment_70101", "id": "reaction_10684660", "reactome": "R-DDI-426043", "name": "2-AG hydrolysis to arachidonate by MAGL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426030", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10684657", "catalyst" ] ], "additional_components": [ "DDB_G0269086" ] }, "reaction_10722777": { "compartment": "compartment_876", "id": "reaction_10722777", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722772" ], "products": [ "species_10722752", "species_10684218" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10684652": { "compartment": "compartment_876", "id": "reaction_10684652", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10684649", "catalyst" ] ], "additional_components": [ "Q54YL1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54ET1", "DDB_G0291354" ] }, "reaction_10676646": { "compartment": "compartment_876", "id": "reaction_10676646", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676641" ], "products": [ "species_10676643" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "species_179856", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_114520", "P34044", "DDB_G0283151", "species_6797635", "species_29438", "Q02158", "DDB_G0292736", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10673792": { "compartment": "compartment_70101", "id": "reaction_10673792", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673796": { "compartment": "compartment_70101", "id": "reaction_10673796", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10674384": { "compartment": "compartment_70101", "id": "reaction_10674384", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q54PM8", "DDB_G0284431" ] }, "reaction_10673794": { "compartment": "compartment_70101", "id": "reaction_10673794", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10673760": { "compartment": "compartment_70101", "id": "reaction_10673760", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10673740": { "compartment": "compartment_70101", "id": "reaction_10673740", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673750": { "compartment": "compartment_70101", "id": "reaction_10673750", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10675646": { "compartment": "compartment_5460", "id": "reaction_10675646", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10722311": { "compartment": "compartment_5460", "id": "reaction_10722311", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10722308", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10679923": { "compartment": "compartment_876", "id": "reaction_10679923", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679514", "species_10679534" ], "products": [ "species_10679536" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q94464", "DDB_G0277849", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487" ] }, "reaction_10669451": { "compartment": "compartment_7660", "id": "reaction_10669451", "reactome": "R-DDI-68595", "name": "ORC2 binds ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669447", "species_10669442" ], "products": [ "species_10669449" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10669460": { "compartment": "compartment_7660", "id": "reaction_10669460", "reactome": "R-DDI-68603", "name": "ORC5 binds ORC2:ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669449", "species_10669456" ], "products": [ "species_10669458" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078" ] }, "reaction_10726116": { "compartment": "compartment_70101", "id": "reaction_10726116", "reactome": "R-DDI-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726114" ], "products": [ "species_10669474" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10669494": { "compartment": "compartment_7660", "id": "reaction_10669494", "reactome": "R-DDI-68615", "name": "Formation of ORC(1-6) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669482", "species_10669490" ], "products": [ "species_10669492" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "DDB_G0284771", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10726142": { "compartment": "compartment_7660", "id": "reaction_10726142", "reactome": "R-DDI-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669474", "species_10726138" ], "products": [ "species_10726140" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54RM2", "DDB_G0283073", "Q76NW2", "DDB_G0276863" ] }, "reaction_10669469": { "compartment": "compartment_7660", "id": "reaction_10669469", "reactome": "R-DDI-68610", "name": "Formation of ORC(2-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669458", "species_10669465" ], "products": [ "species_10669467" ], "modifiers": [ [ "species_29358", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562" ] }, "reaction_10669484": { "compartment": "compartment_7660", "id": "reaction_10669484", "reactome": "R-DDI-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669467", "species_10669478" ], "products": [ "species_10669482" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10696023": { "compartment": "compartment_876", "id": "reaction_10696023", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10709790": { "compartment": "compartment_984", "id": "reaction_10709790", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_2160848", "species_5693343" ], "modifiers": [ [ "species_10709787", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10702727": { "compartment": "compartment_70101", "id": "reaction_10702727", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10683107" ], "products": [ "species_10702725" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54WU6", "DDB_G0279427", "Q54MV2", "DDB_G0285643" ] }, "reaction_10714788": { "compartment": "compartment_70101", "id": "reaction_10714788", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714777", "species_10714784" ], "products": [ "species_10714786" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10711995": { "compartment": "compartment_7660", "id": "reaction_10711995", "reactome": "R-DDI-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676302", "species_10711991" ], "products": [ "species_10711993" ], "modifiers": [], "additional_components": [ "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10714779": { "compartment": "compartment_876", "id": "reaction_10714779", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714775", "species_10714770" ], "products": [ "species_10714777" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10683116": { "compartment": "compartment_70101", "id": "reaction_10683116", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113", "species_29372" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10711979": { "compartment": "compartment_70101", "id": "reaction_10711979", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711969", "species_113592" ], "products": [ "species_29370", "species_10711977" ], "modifiers": [ [ "species_10680163", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10714366": { "compartment": "compartment_70101", "id": "reaction_10714366", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6799725" ], "products": [ "species_29366", "species_6799726" ], "modifiers": [ [ "species_10714301", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10714807": { "compartment": "compartment_17906", "id": "reaction_10714807", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10714802", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10712027": { "compartment": "compartment_7660", "id": "reaction_10712027", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712011" ], "products": [ "species_113582", "species_10712024" ], "modifiers": [ [ "species_10712011", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714862": { "compartment": "compartment_70101", "id": "reaction_10714862", "reactome": "R-DDI-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674703" ], "products": [ "species_10674705" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "P54632", "DDB_G0269138" ] }, "reaction_10671942": { "compartment": "compartment_70101", "id": "reaction_10671942", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10671939", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10670932": { "compartment": "compartment_70101", "id": "reaction_10670932", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10670929", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10712135": { "compartment": "compartment_70101", "id": "reaction_10712135", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712067", "species_10712131" ], "products": [ "species_10712133" ], "modifiers": [], "additional_components": [ "DDB_G0285069", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NU5", "DDB_G0285069", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029" ] }, "reaction_10714804": { "compartment": "compartment_17927", "id": "reaction_10714804", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714798", "species_10714793" ], "products": [ "species_10714802" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10714845": { "compartment": "compartment_7660", "id": "reaction_10714845", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10714828" ], "modifiers": [ [ "species_10714842", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q55G55", "DDB_G0267810", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10711989": { "compartment": "compartment_70101", "id": "reaction_10711989", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711977", "species_113592" ], "products": [ "species_29370", "species_10711987" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10712001": { "compartment": "compartment_7660", "id": "reaction_10712001", "reactome": "R-DDI-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711997", "species_10676302" ], "products": [ "species_10711999" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10702731": { "compartment": "compartment_70101", "id": "reaction_10702731", "reactome": "R-DDI-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680124", "species_10674719" ], "products": [ "species_10702729" ], "modifiers": [], "additional_components": [ "DDB_G0280527", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54VB2", "DDB_G0280527" ] }, "reaction_10712029": { "compartment": "compartment_7660", "id": "reaction_10712029", "reactome": "R-DDI-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711993", "species_10712009" ], "products": [ "species_10712011" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q556Z2", "DDB_G0273207", "Q54I13", "DDB_G0289079", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714303": { "compartment": "compartment_70101", "id": "reaction_10714303", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714299" ], "products": [ "species_10714301" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10699328": { "compartment": "compartment_70101", "id": "reaction_10699328", "reactome": "R-DDI-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10673826" ], "products": [ "species_10673820", "species_29356" ], "modifiers": [ [ "species_10699325", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q54N76", "DDB_G0285741", "Q555L5", "DDB_G0274859" ] }, "reaction_10714091": { "compartment": "compartment_7660", "id": "reaction_10714091", "reactome": "R-DDI-6799097", "name": "ATM phosphorylates ZNF420", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10688366" ], "products": [ "species_113582", "species_10714089" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0281085", "DDB_G0281085", "DDB_G0275845" ] }, "reaction_10702706": { "compartment": "compartment_70101", "id": "reaction_10702706", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10699317" ], "products": [ "species_29356", "species_10702703" ], "modifiers": [ [ "species_10699317", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10680127": { "compartment": "compartment_70101", "id": "reaction_10680127", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10680124" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10702723": { "compartment": "compartment_70101", "id": "reaction_10702723", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10702703" ], "products": [ "species_10702721" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10723422": { "compartment": "compartment_5460", "id": "reaction_10723422", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10723420": { "compartment": "compartment_5460", "id": "reaction_10723420", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692485": { "compartment": "compartment_70101", "id": "reaction_10692485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10724254": { "compartment": "compartment_5460", "id": "reaction_10724254", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724250" ], "products": [ "species_10723093", "species_1655881", "species_10699273" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10716446": { "compartment": "compartment_70101", "id": "reaction_10716446", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10716443", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10724248": { "compartment": "compartment_5460", "id": "reaction_10724248", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723093", "species_9012592" ], "products": [ "species_113557", "species_10724246" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10724252": { "compartment": "compartment_5460", "id": "reaction_10724252", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699270", "species_10724246" ], "products": [ "species_10724250" ], "modifiers": [], "additional_components": [ "DDB_G0284939", "DDB_G0291816", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10692483": { "compartment": "compartment_70101", "id": "reaction_10692483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692466": { "compartment": "compartment_70616", "id": "reaction_10692466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10723096": { "compartment": "compartment_5460", "id": "reaction_10723096", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692464": { "compartment": "compartment_5460", "id": "reaction_10692464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10692461", "catalyst" ] ], "additional_components": [ "species_947539", "Q54XJ8", "DDB_G0278893" ] }, "reaction_10692498": { "compartment": "compartment_70101", "id": "reaction_10692498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10692495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10723424": { "compartment": "compartment_5460", "id": "reaction_10723424", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692477": { "compartment": "compartment_70101", "id": "reaction_10692477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692488": { "compartment": "compartment_70101", "id": "reaction_10692488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10723006": { "compartment": "compartment_5460", "id": "reaction_10723006", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10723003", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_158543", "Q54YN2", "DDB_G0278155" ] }, "reaction_10677142": { "compartment": "compartment_12045", "id": "reaction_10677142", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_162681", "species_29420" ], "modifiers": [ [ "species_10677139", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q54LP3", "DDB_G0286519", "Q76NT6", "DDB_G0277435" ] }, "reaction_10681323": { "compartment": "compartment_70101", "id": "reaction_10681323", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681315" ], "products": [ "species_10681143", "species_29420" ], "modifiers": [ [ "species_10681320", "catalyst" ] ], "additional_components": [ "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "Q559R0", "DDB_G0272296", "DDB_G0286167" ] }, "reaction_10710261": { "compartment": "compartment_12045", "id": "reaction_10710261", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681221", "species_10681331" ], "products": [ "species_10681223" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710091": { "compartment": "compartment_12045", "id": "reaction_10710091", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681096", "species_10681325" ], "products": [ "species_10710089" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0269942", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255" ] }, "reaction_10715624": { "compartment": "compartment_432051", "id": "reaction_10715624", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715620", "species_10715492" ], "products": [ "species_10715622" ], "modifiers": [], "additional_components": [ "Q54I79", "DDB_G0288937", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "Q54VS0", "DDB_G0280175", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "P13022", "DDB_G0272104", "species_29438", "Q54XU5", "DDB_G0278579", "Q54N50", "DDB_G0285503", "P54703", "DDB_G0280849", "Q54TA6", "DDB_G0281889", "Q54VD6", "DDB_G0280435", "species_29420", "Q86A88", "DDB_G0274815", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "Q54ZI7", "DDB_G0277561", "P34036", "DDB_G0276355", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YD8", "DDB_G0278285", "Q54I79", "DDB_G0288937", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54VS0", "DDB_G0280175", "Q54NU2", "DDB_G0284985", "P54703", "DDB_G0280849", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "P34141", "DDB_G0291233", "P34036", "DDB_G0276355", "Q55FU2", "DDB_G0267950", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54N50", "DDB_G0285503", "Q54TA6", "DDB_G0281889", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54Q34", "DDB_G0349530", "Q54V78", "DDB_G0349530", "P13022", "DDB_G0272104", "Q54XU5", "DDB_G0278579", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q54VD6", "DDB_G0280435", "species_29420", "Q1ZXJ2", "DDB_G0294557", "Q54ZI7", "DDB_G0277561", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q86A88", "DDB_G0274815", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735" ] }, "reaction_10715495": { "compartment": "compartment_6791047", "id": "reaction_10715495", "reactome": "R-DDI-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715384" ], "products": [ "species_10715128", "species_10715276", "species_10715492", "species_10715194" ], "modifiers": [ [ "species_10715384", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716722": { "compartment": "compartment_6791047", "id": "reaction_10716722", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716717" ], "products": [ "species_10710015", "species_10716715" ], "modifiers": [ [ "species_10716717", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710154": { "compartment": "compartment_6791047", "id": "reaction_10710154", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710119", "species_10710150", "species_10710110" ], "products": [ "species_10710152" ], "modifiers": [], "additional_components": [ "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710161": { "compartment": "compartment_13959", "id": "reaction_10710161", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710064", "species_10710015", "species_10681311" ], "products": [ "species_10710066" ], "modifiers": [], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q55CT5", "DDB_G0270992", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10710218": { "compartment": "compartment_6791047", "id": "reaction_10710218", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10710176" ], "products": [ "species_29370", "species_10681091", "species_10710180", "species_10710182", "species_10710064", "species_10710103", "species_10710210" ], "modifiers": [ [ "species_10710215", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q553R1", "DDB_G0275331", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q54BK5", "DDB_G0293712", "Q553R1", "DDB_G0275331", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "DDB_G0273059" ] }, "reaction_10715198": { "compartment": "compartment_6791047", "id": "reaction_10715198", "reactome": "R-DDI-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715134", "species_10715194" ], "products": [ "species_10715196" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715136": { "compartment": "compartment_6791047", "id": "reaction_10715136", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715128", "species_10715132", "species_10710210" ], "products": [ "species_10715134" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716719": { "compartment": "compartment_6791047", "id": "reaction_10716719", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716715", "species_10710210" ], "products": [ "species_10716717" ], "modifiers": [], "additional_components": [ "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710157": { "compartment": "compartment_6791047", "id": "reaction_10710157", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710152", "species_113592" ], "products": [ "species_10710126", "species_10710131", "species_10710140", "species_10710124", "species_10710119", "species_10710148", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10710152", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0288719", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710264": { "compartment": "compartment_70101", "id": "reaction_10710264", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681223" ], "products": [ "species_10681221", "species_10681331", "species_29372", "species_10681315" ], "modifiers": [ [ "species_10681223", "catalyst" ] ], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29420", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10715205": { "compartment": "compartment_6791047", "id": "reaction_10715205", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10715196" ], "products": [ "species_10715202", "species_29370" ], "modifiers": [ [ "species_10715196", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715260": { "compartment": "compartment_6791047", "id": "reaction_10715260", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715202", "species_10715256" ], "products": [ "species_10715258" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10715820": { "compartment": "compartment_20699", "id": "reaction_10715820", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715816", "species_10710119", "species_10710110" ], "products": [ "species_10715818" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710087": { "compartment": "compartment_12045", "id": "reaction_10710087", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681157", "species_10681155" ], "products": [ "species_10681163" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0277797", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q55FD0", "DDB_G0268452" ] }, "reaction_10681337": { "compartment": "compartment_12045", "id": "reaction_10681337", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681229", "species_10681091", "species_10681104" ], "products": [ "species_10681231" ], "modifiers": [], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q55BR0", "DDB_G0269198", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q54T59", "DDB_G0281985", "Q55CT5", "DDB_G0270992", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "species_29438", "Q55BR0", "DDB_G0269198", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296" ] }, "reaction_10710159": { "compartment": "compartment_12045", "id": "reaction_10710159", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681217", "species_10681211" ], "products": [ "species_10681219" ], "modifiers": [], "additional_components": [ "DDB_G0280187", "Q8T2J5", "DDB_G0271968", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139" ] }, "reaction_10710073": { "compartment": "compartment_13959", "id": "reaction_10710073", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10710066" ], "products": [ "species_10710070", "species_29420" ], "modifiers": [ [ "species_10710066", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10715814": { "compartment": "compartment_20699", "id": "reaction_10715814", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715791", "species_10715810" ], "products": [ "species_10715812" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q55FD0", "DDB_G0268452", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "Q54QH2", "DDB_G0283831", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10715823": { "compartment": "compartment_20699", "id": "reaction_10715823", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715818", "species_113592" ], "products": [ "species_10715804", "species_10715796", "species_29372", "species_10715800", "species_10715779", "species_10715679", "species_10715798" ], "modifiers": [ [ "species_10715818", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0283831", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10725871": { "compartment": "compartment_70101", "id": "reaction_10725871", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10677557" ], "products": [ "species_10725869" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678991" ] }, "reaction_10689890": { "compartment": "compartment_876", "id": "reaction_10689890", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10689887", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724463": { "compartment": "compartment_876", "id": "reaction_10724463", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724456", "species_179838", "species_113592" ], "products": [ "species_29370", "species_10724461" ], "modifiers": [], "additional_components": [ "DDB_G0281265", "Q54U56", "DDB_G0281265", "species_179838" ] }, "reaction_10676519": { "compartment": "compartment_17906", "id": "reaction_10676519", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676517" ], "products": [ "species_10676515" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10675766": { "compartment": "compartment_7660", "id": "reaction_10675766", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672167", "species_10674774" ], "products": [ "species_10674776" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675764": { "compartment": "compartment_7660", "id": "reaction_10675764", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674115", "species_10674110", "species_10674772" ], "products": [ "species_10674774" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675762": { "compartment": "compartment_7660", "id": "reaction_10675762", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10674181" ], "products": [ "species_10674772" ], "modifiers": [], "additional_components": [ "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675768": { "compartment": "compartment_7660", "id": "reaction_10675768", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10674778" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674780": { "compartment": "compartment_7660", "id": "reaction_10674780", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674193", "species_10674776" ], "products": [ "species_10674778" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675912": { "compartment": "compartment_7660", "id": "reaction_10675912", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675909" ], "products": [ "species_10675902", "species_110216" ], "modifiers": [ [ "species_10675909", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675921": { "compartment": "compartment_7660", "id": "reaction_10675921", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675916" ], "products": [ "species_110223", "species_10675918" ], "modifiers": [ [ "species_10675916", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675942": { "compartment": "compartment_7660", "id": "reaction_10675942", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675939" ], "products": [ "species_10675918", "species_5637659" ], "modifiers": [ [ "species_10675939", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675905": { "compartment": "compartment_7660", "id": "reaction_10675905", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675898" ], "products": [ "species_10675902", "species_29554" ], "modifiers": [ [ "species_10675898", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675961": { "compartment": "compartment_7660", "id": "reaction_10675961", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675958" ], "products": [ "species_10675953", "species_5636006" ], "modifiers": [ [ "species_10675958", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675935": { "compartment": "compartment_7660", "id": "reaction_10675935", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675932" ], "products": [ "species_30140", "species_10675918" ], "modifiers": [ [ "species_10675932", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675928": { "compartment": "compartment_7660", "id": "reaction_10675928", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675925" ], "products": [ "species_10675918", "species_110225" ], "modifiers": [ [ "species_10675925", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10699054": { "compartment": "compartment_984", "id": "reaction_10699054", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10699051", "catalyst" ] ], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699338": { "compartment": "compartment_70101", "id": "reaction_10699338", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10699335", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54SE2", "DDB_G0282517", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10699064": { "compartment": "compartment_70101", "id": "reaction_10699064", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10699061", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10675004": { "compartment": "compartment_17951", "id": "reaction_10675004", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10675001", "catalyst" ] ], "additional_components": [ "O77229", "DDB_G0274595", "species_71185", "species_5623644" ] }, "reaction_10699781": { "compartment": "compartment_70101", "id": "reaction_10699781", "reactome": "R-DDI-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222481", "species_10673826" ], "products": [ "species_10673820", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10699323", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "DDB_G0285741" ] }, "reaction_10699292": { "compartment": "compartment_5460", "id": "reaction_10699292", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10699270" ], "products": [ "species_113521", "species_10699273" ], "modifiers": [ [ "species_10699289", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54N76", "DDB_G0285741", "Q54W09", "DDB_G0279973" ] }, "reaction_10699784": { "compartment": "compartment_5460", "id": "reaction_10699784", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3697881", "species_10699270" ], "products": [ "species_113521", "species_3697842", "species_10699273" ], "modifiers": [ [ "species_10699287", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10715116": { "compartment": "compartment_12045", "id": "reaction_10715116", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_70106", "species_29366", "species_1222424" ], "modifiers": [ [ "species_10715113", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10699307": { "compartment": "compartment_70616", "id": "reaction_10699307", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_3341308" ], "products": [ "species_10677282", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10699937": { "compartment": "compartment_17927", "id": "reaction_10699937", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10699934", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10698995": { "compartment": "compartment_5460", "id": "reaction_10698995", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10698992", "catalyst" ] ], "additional_components": [ "species_29418", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10700993": { "compartment": "compartment_17963", "id": "reaction_10700993", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700991" ], "products": [ "species_10699051" ], "modifiers": [], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420", "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699301": { "compartment": "compartment_5460", "id": "reaction_10699301", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10699298", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10697280": { "compartment": "compartment_70101", "id": "reaction_10697280", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10697277", "catalyst" ] ], "additional_components": [ "Q54S89", "DDB_G0282603", "species_29926" ] }, "reaction_10670550": { "compartment": "compartment_7660", "id": "reaction_10670550", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670546", "species_10670361" ], "products": [ "species_10670548" ], "modifiers": [], "additional_components": [ "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702" ] }, "reaction_10670588": { "compartment": "compartment_7660", "id": "reaction_10670588", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670563", "species_10670584" ], "products": [ "species_10670586" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670565": { "compartment": "compartment_7660", "id": "reaction_10670565", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670559" ], "products": [ "species_10670546", "species_10670563" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607" ] }, "reaction_10670561": { "compartment": "compartment_7660", "id": "reaction_10670561", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_29358", "species_10670548" ], "products": [ "species_113582", "species_10670559" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702" ] }, "reaction_10716868": { "compartment": "compartment_20699", "id": "reaction_10716868", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716859" ], "products": [ "species_10716865" ], "modifiers": [ [ "species_10716859", "catalyst" ] ], "additional_components": [ "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771", "species_29420", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10717007": { "compartment": "compartment_20699", "id": "reaction_10717007", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717003", "species_10715666" ], "products": [ "species_10717005" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716805": { "compartment": "compartment_20699", "id": "reaction_10716805", "reactome": "R-DDI-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716801" ], "products": [ "species_10716803" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "O00909", "DDB_G0289173", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "CHEBI:15996" ] }, "reaction_10716884": { "compartment": "compartment_20699", "id": "reaction_10716884", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716880", "species_10716874" ], "products": [ "species_10716882" ], "modifiers": [], "additional_components": [ "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716861": { "compartment": "compartment_20699", "id": "reaction_10716861", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716831" ], "products": [ "species_10716859" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10716313": { "compartment": "compartment_20699", "id": "reaction_10716313", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716309", "species_10715666" ], "products": [ "species_10716311" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q551H5", "DDB_G0276575", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q55FD0", "DDB_G0268452", "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q551H5", "DDB_G0276575", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716784": { "compartment": "compartment_20699", "id": "reaction_10716784", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716780", "species_10710119", "species_10710110" ], "products": [ "species_10716782" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10716787": { "compartment": "compartment_20699", "id": "reaction_10716787", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716782" ], "products": [ "species_29370", "species_10715796", "species_10710119", "species_10715800", "species_10715679", "species_10710110", "species_10715798" ], "modifiers": [ [ "species_10716782", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0277565", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10709489": { "compartment": "compartment_70101", "id": "reaction_10709489", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709484", "species_29356" ], "products": [ "species_1131871", "species_10709486" ], "modifiers": [ [ "species_10709484", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10703500": { "compartment": "compartment_70101", "id": "reaction_10703500", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703441", "species_10670356" ], "products": [ "species_10703443" ], "modifiers": [], "additional_components": [ "DDB_G0272624", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703447": { "compartment": "compartment_70101", "id": "reaction_10703447", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703443", "species_10703436" ], "products": [ "species_10703445" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "DDB_G0285527", "Q54N38", "DDB_G0285527", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10717861": { "compartment": "compartment_70101", "id": "reaction_10717861", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717713" ], "products": [ "species_76577", "species_10717709" ], "modifiers": [ [ "species_10717713", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10702140": { "compartment": "compartment_70101", "id": "reaction_10702140", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702129" ], "products": [ "species_10702132", "species_71285" ], "modifiers": [ [ "species_10702137", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10700403": { "compartment": "compartment_7660", "id": "reaction_10700403", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10696675" ], "products": [ "species_10698305", "species_10700401" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10673665": { "compartment": "compartment_70101", "id": "reaction_10673665", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673661", "species_10673298" ], "products": [ "species_10673300" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10687107": { "compartment": "compartment_17957", "id": "reaction_10687107", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686806", "species_10687103" ], "products": [ "species_10687105" ], "modifiers": [], "additional_components": [ "Q54BW3", "DDB_G0293378", "Q54EN4", "DDB_G0291434", "Q23858", "DDB_G0283539", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "Q54BW3", "DDB_G0293378", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q54EN4", "DDB_G0291434" ] }, "reaction_10700206": { "compartment": "compartment_7660", "id": "reaction_10700206", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684083", "species_10698318" ], "products": [ "species_10698305", "species_10700198" ], "modifiers": [ [ "species_10700203", "catalyst" ] ], "additional_components": [ "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54UJ3", "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "DDB_G0281183" ] }, "reaction_10700515": { "compartment": "compartment_7660", "id": "reaction_10700515", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700491" ], "products": [ "species_10700504", "species_10698305" ], "modifiers": [ [ "species_10700512", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0278203", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10705691": { "compartment": "compartment_3828046", "id": "reaction_10705691", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705524", "species_5685882" ], "products": [ "species_10705620", "species_10705588", "species_10705556" ], "modifiers": [ [ "species_10705688", "catalyst" ] ], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10683855": { "compartment": "compartment_70101", "id": "reaction_10683855", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683798", "species_10683851" ], "products": [ "species_10683853" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q6B516", "DDB_G0284545", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741" ] }, "reaction_10673340": { "compartment": "compartment_70101", "id": "reaction_10673340", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673329" ], "products": [ "species_29370", "species_10673329", "species_29372" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10684883": { "compartment": "compartment_17938", "id": "reaction_10684883", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10684880", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10685907": { "compartment": "compartment_70101", "id": "reaction_10685907", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10685904", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10709063": { "compartment": "compartment_7660", "id": "reaction_10709063", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10707630" ], "products": [ "species_10709060", "species_10707644" ], "modifiers": [ [ "species_10707630", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10685919": { "compartment": "compartment_5460", "id": "reaction_10685919", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10685916", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10676992": { "compartment": "compartment_70101", "id": "reaction_10676992", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676983", "species_10676987" ], "products": [ "species_10676969", "species_10676989" ], "modifiers": [ [ "species_10676983", "catalyst" ] ], "additional_components": [ "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10724695": { "compartment": "compartment_12045", "id": "reaction_10724695", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724693" ], "products": [ "species_10705524" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10682226": { "compartment": "compartment_876", "id": "reaction_10682226", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682212", "species_10682207", "species_10682222", "species_10682192", "species_10682187", "species_10682217", "species_10682197", "species_10682202" ], "products": [ "species_10682224" ], "modifiers": [], "additional_components": [ "DDB_G0285067", "DDB_G0279991", "DDB_G0272991", "DDB_G0280081", "DDB_G0284833", "DDB_G0293520", "DDB_G0287881", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54VX5", "DDB_G0280081", "Q558Z9", "DDB_G0272991", "Q54VZ8", "DDB_G0279991", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54P76", "DDB_G0284833", "Q54B27", "DDB_G0293936" ] }, "reaction_10710630": { "compartment": "compartment_7660", "id": "reaction_10710630", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710625" ], "products": [ "species_10709060", "species_10710627" ], "modifiers": [ [ "species_10710625", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10698407": { "compartment": "compartment_7660", "id": "reaction_10698407", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698318" ], "products": [ "species_10698305", "species_10698405" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54C05", "DDB_G0293300", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710874": { "compartment": "compartment_7660", "id": "reaction_10710874", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710869" ], "products": [ "species_10708452", "species_10710871" ], "modifiers": [ [ "species_10710869", "catalyst" ] ], "additional_components": [ "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827" ] }, "reaction_10686727": { "compartment": "compartment_70101", "id": "reaction_10686727", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10686724", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10711136": { "compartment": "compartment_70101", "id": "reaction_10711136", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10711133", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10722373": { "compartment": "compartment_17947", "id": "reaction_10722373", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722365", "species_10722369" ], "products": [ "species_10722371" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10711128": { "compartment": "compartment_70101", "id": "reaction_10711128", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10687947": { "compartment": "compartment_70101", "id": "reaction_10687947", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687940" ], "products": [ "species_10670153", "species_10687942" ], "modifiers": [ [ "species_10687944", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10673351": { "compartment": "compartment_70101", "id": "reaction_10673351", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673316", "species_10673311", "species_10673321" ], "products": [ "species_10673323" ], "modifiers": [], "additional_components": [ "DDB_G0268574", "P90529", "DDB_G0269146", "DDB_G0275395", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574" ] }, "reaction_10702162": { "compartment": "compartment_70101", "id": "reaction_10702162", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702142" ], "products": [ "species_353106", "species_10702129" ], "modifiers": [ [ "species_10702159", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "B0G132", "DDB_G0295687", "Q54PW5", "DDB_G0284257", "Q7KWL8", "DDB_G0277061" ] }, "reaction_10673659": { "compartment": "compartment_70101", "id": "reaction_10673659", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673640" ], "products": [ "species_10673277", "species_10673638", "species_10673208" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0278205", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10709775": { "compartment": "compartment_984", "id": "reaction_10709775", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_109276" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10709772", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10722383": { "compartment": "compartment_17947", "id": "reaction_10722383", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722371" ], "products": [ "species_10690046", "species_10722380" ], "modifiers": [ [ "species_10722371", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10673655": { "compartment": "compartment_70101", "id": "reaction_10673655", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673649" ], "products": [ "species_10673651", "species_29372", "species_10673653" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", 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"Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "species_29420", "Q54XP6", "DDB_G0278815", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10677197": { "compartment": "compartment_12045", "id": "reaction_10677197", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10677194", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10681359": { "compartment": "compartment_70101", "id": "reaction_10681359", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_204628", "species_10681343" ], "products": [ "species_29360", "species_204635", "species_10681347" ], "modifiers": [ [ "species_10681356", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10688493": { "compartment": "compartment_17963", "id": "reaction_10688493", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10688490", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10717967": { "compartment": "compartment_70101", "id": "reaction_10717967", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717965" ], "products": [ "species_10669997", "species_10669975", "species_10670019" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10702126": { "compartment": "compartment_70101", "id": "reaction_10702126", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_31633", "species_10702118" ], "products": [ "species_10676998", "species_111294", "species_76577" ], "modifiers": [ [ "species_10702123", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10698428": { "compartment": "compartment_7660", "id": "reaction_10698428", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698412", "species_10698318" ], "products": [ "species_10698305", "species_10698425" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54LN0", "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10716428": { "compartment": "compartment_70101", "id": "reaction_10716428", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682961", "species_10683851" ], "products": [ "species_10716426" ], "modifiers": [], "additional_components": [ "DDB_G0277143", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10721435": { "compartment": "compartment_70101", "id": "reaction_10721435", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721415", "species_10721431", "species_10721429" ], "products": [ "species_10721433" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10677189": { "compartment": "compartment_12045", "id": "reaction_10677189", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10677186", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10721463": { "compartment": "compartment_70101", "id": "reaction_10721463", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721452", "species_10721450" ], "products": [ "species_10721443", "species_10721460", "species_10680834" ], "modifiers": [ [ "species_10721452", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0277267", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10700718": { "compartment": "compartment_7660", "id": "reaction_10700718", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670555", "species_10698318" ], "products": [ "species_10698305", "species_10700716" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10721734": { "compartment": "compartment_7660", "id": "reaction_10721734", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721712", "species_10721731" ], "products": [ "species_10721719", "species_10705259", "species_10721729", "species_10721706" ], "modifiers": [ [ "species_10721731", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082", "Q54K47", "DDB_G0287607", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "DDB_G0272082", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10700659": { "compartment": "compartment_7660", "id": "reaction_10700659", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700639" ], "products": [ "species_10698305", "species_10700657" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0272690", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685756": { "compartment": "compartment_70101", "id": "reaction_10685756", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10685753", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10685711": { "compartment": "compartment_17957", "id": "reaction_10685711", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10685708", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10719651": { "compartment": "compartment_70101", "id": "reaction_10719651", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719273", "species_10719647" ], "products": [ "species_10719649" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10711110": { "compartment": "compartment_70101", "id": "reaction_10711110", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10711107", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10700169": { "compartment": "compartment_7660", "id": "reaction_10700169", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698318" ], "products": [ "species_10698305", "species_10700167" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10707595": { "compartment": "compartment_70101", "id": "reaction_10707595", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707592", "species_10689017" ], "products": [ "species_10706130" ], "modifiers": [ [ "species_10689017", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10711231": { "compartment": "compartment_12045", "id": "reaction_10711231", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ] ], "additional_components": [ "species_29426", "Q558K8", "DDB_G0272799" ] }, "reaction_10717943": { "compartment": "compartment_70101", "id": "reaction_10717943", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717940" ], "products": [ "species_10670107", "species_10669997", "species_10670151", "species_10670085", "species_10670063", "species_10669975", "species_10670041", "species_10670019", "species_10670129" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10672012": { "compartment": "compartment_70101", "id": "reaction_10672012", "reactome": "R-DDI-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10672009", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10717761": { "compartment": "compartment_70101", "id": "reaction_10717761", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717711", "species_10717707" ], "products": [ "species_10717759", "species_10717713" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q75JE1", "DDB_G0288345", "O76542", "DDB_G0284009", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10685772": { "compartment": "compartment_12045", "id": "reaction_10685772", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10685769", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10685897": { "compartment": "compartment_70101", "id": "reaction_10685897", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10685894", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10687188": { "compartment": "compartment_17963", "id": "reaction_10687188", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_205687", "species_10687186" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700814": { "compartment": "compartment_7660", "id": "reaction_10700814", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700799", "species_10698318" ], "products": [ "species_10698305", "species_10700812" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54RC3", "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717887": { "compartment": "compartment_70101", "id": "reaction_10717887", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689659", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10717884", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628", "species_6799543", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10716434": { "compartment": "compartment_70101", "id": "reaction_10716434", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716432" ], "products": [ "species_10716426", "species_29372" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10677122": { "compartment": "compartment_17957", "id": "reaction_10677122", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10677119", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10711139": { "compartment": "compartment_70101", "id": "reaction_10711139", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10673349": { "compartment": "compartment_70101", "id": "reaction_10673349", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347" ], "products": [ "species_10673345", "species_10673316" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10685719": { "compartment": "compartment_12045", "id": "reaction_10685719", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449744", "species_29356" ], "products": [ "species_449299", "species_29372" ], "modifiers": [ [ "species_10685716", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10698470": { "compartment": "compartment_7660", "id": "reaction_10698470", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698438" ], "products": [ "species_10698305", "species_10698453" ], "modifiers": [ [ "species_10698467", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0285989", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54MF7", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10711352": { "compartment": "compartment_3828046", "id": "reaction_10711352", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705556" ], "products": [ "species_10705693" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10677228": { "compartment": "compartment_12045", "id": "reaction_10677228", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855665", "species_449229" ], "products": [ "species_162872", "species_8855659" ], "modifiers": [ [ "species_10677225", "catalyst" ] ], "additional_components": [ "Q54IA4", "DDB_G0288899", "Q54QP2", "DDB_G0283717" ] }, "reaction_10717705": { "compartment": "compartment_7660", "id": "reaction_10717705", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717501", "species_29358", "species_10669917" ], "products": [ "species_10717703", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721722": { "compartment": "compartment_7660", "id": "reaction_10721722", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721714", "species_10721712" ], "products": [ "species_10721719", "species_10721697", "species_10705259", "species_10721706" ], "modifiers": [ [ "species_10721714", "catalyst" ] ], "additional_components": [ "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10721724": { "compartment": "compartment_7660", "id": "reaction_10721724", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721697", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721714" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10719266": { "compartment": "compartment_70101", "id": "reaction_10719266", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719256", "species_10719262" ], "products": [ "species_10719264" ], "modifiers": [ [ "species_10719258", "inhibitor" ] ], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10718520": { "compartment": "compartment_7660", "id": "reaction_10718520", "reactome": "R-DDI-8862184", "name": "USP48 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718471" ], "products": [ "species_10718517", "species_10708452" ], "modifiers": [ [ "species_10718471", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961" ] }, "reaction_10700592": { "compartment": "compartment_7660", "id": "reaction_10700592", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10674568" ], "products": [ "species_10698305", "species_10700590" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0276863", "DDB_G0287693", "DDB_G0276863", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10707609": { "compartment": "compartment_70101", "id": "reaction_10707609", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707605", "species_10703443" ], "products": [ "species_10707607" ], "modifiers": [], "additional_components": [ "DDB_G0271264", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q55BC4", "DDB_G0271264", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10719260": { "compartment": "compartment_70101", "id": "reaction_10719260", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719254", "species_10719256" ], "products": [ "species_10719258" ], "modifiers": [], "additional_components": [ "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10700140": { "compartment": "compartment_7660", "id": "reaction_10700140", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698387", "species_10698318" ], "products": [ "species_10698305", "species_10700138" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676985": { "compartment": "compartment_70101", "id": "reaction_10676985", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676976", "species_10676974", "species_10676981" ], "products": [ "species_10676983" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0284035", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10717858": { "compartment": "compartment_70101", "id": "reaction_10717858", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10717709" ], "products": [ "species_10717711", "species_111294" ], "modifiers": [ [ "species_10717709", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10720438": { "compartment": "compartment_70101", "id": "reaction_10720438", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720435" ], "products": [ "species_10680330" ], "modifiers": [ [ "species_10715078", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0267906" ] }, "reaction_10700761": { "compartment": "compartment_7660", "id": "reaction_10700761", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700746" ], "products": [ "species_10698305", "species_10700759" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0270418", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717853": { "compartment": "compartment_7660", "id": "reaction_10717853", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717765", "species_10717800" ], "products": [ "species_10717851", "species_10717703" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721441": { "compartment": "compartment_70101", "id": "reaction_10721441", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721433", "species_10721431" ], "products": [ "species_10689176", "species_10721438", "species_10721429" ], "modifiers": [ [ "species_10721433", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0281167", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10676955": { "compartment": "compartment_70101", "id": "reaction_10676955", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673638" ], "products": [ "species_10673430", "species_10676953" ], "modifiers": [], "additional_components": [ "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0275881", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10710713": { "compartment": "compartment_70101", "id": "reaction_10710713", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710704", "species_29356" ], "products": [ "species_10678140", "species_10710710" ], "modifiers": [ [ "species_10710704", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021" ] }, "reaction_10685790": { "compartment": "compartment_12045", "id": "reaction_10685790", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10685787", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10685738": { "compartment": "compartment_70101", "id": "reaction_10685738", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10685735", "catalyst" ] ], "additional_components": [ "Q86B09", "DDB_G0272781", "Q54X03", "DDB_G0279289" ] }, "reaction_10700634": { "compartment": "compartment_7660", "id": "reaction_10700634", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700619" ], "products": [ "species_10698305", "species_10700632" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0292296", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10689669": { "compartment": "compartment_20699", "id": "reaction_10689669", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10689666", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10685695": { "compartment": "compartment_12045", "id": "reaction_10685695", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10685692", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10705340": { "compartment": "compartment_2133233", "id": "reaction_10705340", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10705337", "catalyst" ] ], "additional_components": [ "species_1524042", "species_426925", "species_1524042", "species_426925", "DDB_G0291994" ] }, "reaction_10677244": { "compartment": "compartment_12045", "id": "reaction_10677244", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10677241", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10717918": { "compartment": "compartment_70101", "id": "reaction_10717918", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717916" ], "products": [ "species_10669973", "species_10673551" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "DDB_G0281703", "DDB_G0281703", "DDB_G0281703", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10718833": { "compartment": "compartment_70101", "id": "reaction_10718833", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_10683047", "species_113592" ], "products": [ "species_29370", "species_10718821", "species_29372" ], "modifiers": [ [ "species_10718830", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54TU1", "DDB_G0281541" ] }, "reaction_10677174": { "compartment": "compartment_70101", "id": "reaction_10677174", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_110096", "species_8855657" ], "modifiers": [ [ "species_10677171", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q86K35", "DDB_G0277289", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515", "Q54QB2", "DDB_G0283965", "Q86JM6", "DDB_G0272006" ] }, "reaction_10693457": { "compartment": "compartment_70101", "id": "reaction_10693457", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693453", "species_10693451" ], "products": [ "species_10693455" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q75K18", "DDB_G0275455", "Q554G7", "DDB_G0275211", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q1ZXE8", "DDB_G0285821", "Q55GL2", "DDB_G0267622", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q556L1", "DDB_G0272590", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q1ZXE8", "DDB_G0285821", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54EP7", "DDB_G0291412", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q554G7", "DDB_G0275211", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q75K18", "DDB_G0275455", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q55GL2", "DDB_G0267622", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700486": { "compartment": "compartment_7660", "id": "reaction_10700486", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10696675" ], "products": [ "species_10698305", "species_10700484" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10709672": { "compartment": "compartment_70101", "id": "reaction_10709672", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10670158", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0272566" ] }, "reaction_10717499": { "compartment": "compartment_70101", "id": "reaction_10717499", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717444", "species_10717446" ], "products": [ "species_10717448", "species_10717497" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q555G0", "DDB_G0274897", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721736": { "compartment": "compartment_7660", "id": "reaction_10721736", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721729", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721731" ], "modifiers": [], "additional_components": [ "DDB_G0272082", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10721572": { "compartment": "compartment_984", "id": "reaction_10721572", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10721532" ], "products": [ "species_2197633", "species_10721564" ], "modifiers": [ [ "species_10721569", "catalyst" ] ], "additional_components": [ "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "DDB_G0276919" ] }, "reaction_10685457": { "compartment": "compartment_1462052", "id": "reaction_10685457", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685454", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10685780": { "compartment": "compartment_17957", "id": "reaction_10685780", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10716436": { "compartment": "compartment_70101", "id": "reaction_10716436", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716426" ], "products": [ "species_10716432", "species_29370" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10698263": { "compartment": "compartment_7660", "id": "reaction_10698263", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698249" ], "products": [ "species_10687009" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685703": { "compartment": "compartment_12045", "id": "reaction_10685703", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449221", "species_110614" ], "products": [ "species_449299", "species_110094" ], "modifiers": [ [ "species_10685700", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10710774": { "compartment": "compartment_70101", "id": "reaction_10710774", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_10710770" ], "products": [ "species_10710772" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "P90532", "DDB_G0288065", "Q55BI3", "DDB_G0271346" ] }, "reaction_10717864": { "compartment": "compartment_70101", "id": "reaction_10717864", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10689276" ], "products": [ "species_111294", "species_10717713" ], "modifiers": [ [ "species_10689276", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272" ] }, "reaction_10709185": { "compartment": "compartment_7660", "id": "reaction_10709185", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10709180" ], "products": [ "species_10709182", "species_10669917" ], "modifiers": [ [ "species_10709180", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207" ] }, "reaction_10685465": { "compartment": "compartment_20699", "id": "reaction_10685465", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685462", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10700068": { "compartment": "compartment_7660", "id": "reaction_10700068", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700053" ], "products": [ "species_10698305", "species_10700066" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0293168", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685746": { "compartment": "compartment_17957", "id": "reaction_10685746", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10685743", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10709951": { "compartment": "compartment_17963", "id": "reaction_10709951", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10687208": { "compartment": "compartment_17963", "id": "reaction_10687208", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_10687206", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700701": { "compartment": "compartment_7660", "id": "reaction_10700701", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10690036" ], "products": [ "species_10698305", "species_10700699" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700091": { "compartment": "compartment_7660", "id": "reaction_10700091", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698318" ], "products": [ "species_10698305", "species_10700089" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700359": { "compartment": "compartment_12045", "id": "reaction_10700359", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10709911": { "compartment": "compartment_161320", "id": "reaction_10709911", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10709908", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10700546": { "compartment": "compartment_7660", "id": "reaction_10700546", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700537", "species_10698378" ], "products": [ "species_10698305", "species_10700543" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700462": { "compartment": "compartment_7660", "id": "reaction_10700462", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700203" ], "products": [ "species_10698305", "species_10700460" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0281183", "DDB_G0287693", "Q54UA7", "DDB_G0281183", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10719275": { "compartment": "compartment_70101", "id": "reaction_10719275", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719271", "species_10719264", "species_1131164" ], "products": [ "species_10719273" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10700644": { "compartment": "compartment_7660", "id": "reaction_10700644", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700639" ], "products": [ "species_10698305", "species_10700642" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0272690", "DDB_G0287693", "DDB_G0272690", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10673657": { "compartment": "compartment_70101", "id": "reaction_10673657", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673336", "species_10673638", "species_10673647" ], "products": [ "species_10673649" ], "modifiers": [], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54XP6", "DDB_G0278815", "species_29438", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "species_29438", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700794": { "compartment": "compartment_7660", "id": "reaction_10700794", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700746" ], "products": [ "species_10698305", "species_10700792" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0270418", "DDB_G0287693", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10700185": { "compartment": "compartment_7660", "id": "reaction_10700185", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698750" ], "products": [ "species_10698305", "species_10700183" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0279509", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10710812": { "compartment": "compartment_70101", "id": "reaction_10710812", "reactome": "R-DDI-6782106", "name": "USP10 deubiquitinates SNX3, CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710805", "species_29356" ], "products": [ "species_10707592", "species_10710809" ], "modifiers": [ [ "species_10710805", "catalyst" ] ], "additional_components": [ "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021" ] }, "reaction_10689661": { "compartment": "compartment_70101", "id": "reaction_10689661", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689657" ], "products": [ "species_10689659" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628" ] }, "reaction_10698392": { "compartment": "compartment_7660", "id": "reaction_10698392", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698378" ], "products": [ "species_10698305", "species_10698381" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10698599": { "compartment": "compartment_7660", "id": "reaction_10698599", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10697630" ], "products": [ "species_10698305", "species_10698563" ], "modifiers": [ [ "species_10698596", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0287693", "Q54QR0", "DDB_G0283681", "Q8N0B4", "DDB_G0286189", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q55FZ7", "DDB_G0267886", "Q552D9", "DDB_G0276101", "Q54FE3", "DDB_G0290919", "Q54X37", "DDB_G0279231", "Q54T56", "DDB_G0281991", "Q54I56", "DDB_G0288993", "Q54PA3", "DDB_G0284679", "Q54HN3", "DDB_G0289341" ] }, "reaction_10698300": { "compartment": "compartment_7660", "id": "reaction_10698300", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698296" ], "products": [ "species_10698298" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10677213": { "compartment": "compartment_12045", "id": "reaction_10677213", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10677210", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10710428": { "compartment": "compartment_70101", "id": "reaction_10710428", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710419", "species_29356" ], "products": [ "species_10707592", "species_10710425" ], "modifiers": [ [ "species_10710419", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617" ] }, "reaction_10710452": { "compartment": "compartment_7660", "id": "reaction_10710452", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710445", "species_113518" ], "products": [ "species_10709060", "species_10710449" ], "modifiers": [ [ "species_10710445", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10719196": { "compartment": "compartment_70101", "id": "reaction_10719196", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10719191" ], "products": [ "species_10707592", "species_10719193" ], "modifiers": [ [ "species_10710400", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "B0G199", "DDB_G0293770", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "DDB_G0293770" ] }, "reaction_10710405": { "compartment": "compartment_70101", "id": "reaction_10710405", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710396", "species_29356" ], "products": [ "species_10707592", "species_10710398" ], "modifiers": [ [ "species_10710396", "catalyst" ] ], "additional_components": [ "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407" ] }, "reaction_10673667": { "compartment": "compartment_70101", "id": "reaction_10673667", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "products": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753" ] }, "reaction_10700260": { "compartment": "compartment_7660", "id": "reaction_10700260", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700245" ], "products": [ "species_10698305", "species_10700258" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0283605", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673359": { "compartment": "compartment_70101", "id": "reaction_10673359", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673296", "species_72393" ], "products": [ "species_10673298" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10698243": { "compartment": "compartment_7660", "id": "reaction_10698243", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698225", "species_10687009", "species_29358" ], "products": [ "species_10698240", "species_164121", "species_113541" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10698321": { "compartment": "compartment_7660", "id": "reaction_10698321", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698240" ], "products": [ "species_10698225", "species_10698318" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10717914": { "compartment": "compartment_70101", "id": "reaction_10717914", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669975" ], "products": [ "species_10673140", "species_10669975" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10677002": { "compartment": "compartment_70101", "id": "reaction_10677002", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676998" ], "products": [ "species_10677000" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10676951": { "compartment": "compartment_70101", "id": "reaction_10676951", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676926", "species_10676947" ], "products": [ "species_10676949" ], "modifiers": [], "additional_components": [ "DDB_G0275881", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10706098": { "compartment": "compartment_70101", "id": "reaction_10706098", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140", "species_29356" ], "products": [ "species_10678140", "species_10678138" ], "modifiers": [ [ "species_10706095", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DI9", "DDB_G0269646" ] }, "reaction_10698483": { "compartment": "compartment_7660", "id": "reaction_10698483", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10698438" ], "products": [ "species_10698305", "species_10698480" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0285989", "DDB_G0287693", "DDB_G0285989", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10717855": { "compartment": "compartment_7660", "id": "reaction_10717855", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10717763", "species_10669917" ], "products": [ "species_10717765", "species_113541" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10710584": { "compartment": "compartment_70101", "id": "reaction_10710584", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710535", "species_29356" ], "products": [ "species_10710581", "species_10678140" ], "modifiers": [ [ "species_10710535", "catalyst" ] ], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202" ] }, "reaction_10700105": { "compartment": "compartment_7660", "id": "reaction_10700105", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698368" ], "products": [ "species_10698305", "species_10700102" ], "modifiers": [ [ "species_10686997", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10717866": { "compartment": "compartment_7660", "id": "reaction_10717866", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717703" ], "products": [ "species_10717763", "species_164121" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10686910": { "compartment": "compartment_20699", "id": "reaction_10686910", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10686907", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10700741": { "compartment": "compartment_7660", "id": "reaction_10700741", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10699886" ], "products": [ "species_10698305", "species_10700739" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700532": { "compartment": "compartment_7660", "id": "reaction_10700532", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988", "species_10698318" ], "products": [ "species_10698305", "species_10700530" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0269406", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677205": { "compartment": "compartment_12045", "id": "reaction_10677205", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10677202", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10709123": { "compartment": "compartment_70101", "id": "reaction_10709123", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709118", "species_29356" ], "products": [ "species_10670153", "species_10709120" ], "modifiers": [ [ "species_10709118", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239" ] }, "reaction_10699567": { "compartment": "compartment_7660", "id": "reaction_10699567", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10699553" ], "products": [ "species_10698305", "species_10699556" ], "modifiers": [ [ "species_10699564", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0293468", "DDB_G0287693", "DDB_G0293468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710662": { "compartment": "compartment_7660", "id": "reaction_10710662", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710657" ], "products": [ "species_10669917", "species_10710659" ], "modifiers": [ [ "species_10710657", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273" ] }, "reaction_10700223": { "compartment": "compartment_7660", "id": "reaction_10700223", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700208" ], "products": [ "species_10698305", "species_10700221" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0284411", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677236": { "compartment": "compartment_70101", "id": "reaction_10677236", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10677233", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10710615": { "compartment": "compartment_7660", "id": "reaction_10710615", "reactome": "R-DDI-5696947", "name": "USP47 deubiquitinates POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710610", "species_113518" ], "products": [ "species_10709060", "species_10710612" ], "modifiers": [ [ "species_10710610", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611" ] }, "reaction_10685782": { "compartment": "compartment_17957", "id": "reaction_10685782", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10673663": { "compartment": "compartment_70101", "id": "reaction_10673663", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673208", "species_10673272" ], "products": [ "species_10673661" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54X97", "DDB_G0279109", "Q54CC5", "DDB_G0293052", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "Q54EQ1", "DDB_G0291404", "Q54UD0", "DDB_G0281153", "Q54MT0", "DDB_G0285683", "Q86B20", "DDB_G0272078", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q554U9", "DDB_G0274627", "Q54KZ8", "DDB_G0287005", "Q54C49", "DDB_G0293254", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10700351": { "compartment": "compartment_12045", "id": "reaction_10700351", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10700348", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10685687": { "compartment": "compartment_17957", "id": "reaction_10685687", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10685684", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10687242": { "compartment": "compartment_17963", "id": "reaction_10687242", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10687149" ], "products": [ "species_205687", "species_10687240" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700789": { "compartment": "compartment_7660", "id": "reaction_10700789", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700770" ], "products": [ "species_10698305", "species_10700787" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "P90520", "DDB_G0279737", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10698272": { "compartment": "compartment_7660", "id": "reaction_10698272", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698268" ], "products": [ "species_10698270" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685678": { "compartment": "compartment_17957", "id": "reaction_10685678", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10685670", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10687198": { "compartment": "compartment_17963", "id": "reaction_10687198", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10687149" ], "products": [ "species_205687", "species_10687196" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10710692": { "compartment": "compartment_7660", "id": "reaction_10710692", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710685" ], "products": [ "species_10709060", "species_10710689" ], "modifiers": [ [ "species_10710685", "catalyst" ] ], "additional_components": [ "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453" ] }, "reaction_10700614": { "compartment": "compartment_7660", "id": "reaction_10700614", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10674568" ], "products": [ "species_10698305", "species_10700612" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0276863", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q76NW2", "DDB_G0276863", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673357": { "compartment": "compartment_70101", "id": "reaction_10673357", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673294" ], "products": [ "species_10673296" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10711118": { "compartment": "compartment_70101", "id": "reaction_10711118", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10711115", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10710386": { "compartment": "compartment_70101", "id": "reaction_10710386", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10710383", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0284037" ] }, "reaction_10720401": { "compartment": "compartment_70101", "id": "reaction_10720401", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719649", "species_1131164" ], "products": [ "species_111294", "species_10720396", "species_10720398" ], "modifiers": [ [ "species_10719649", "catalyst" ] ], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10681376": { "compartment": "compartment_70101", "id": "reaction_10681376", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10681343", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10681364" ], "modifiers": [ [ "species_10681373", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "species_71067", "Q556G4", "DDB_G0272634" ] }, "reaction_10685764": { "compartment": "compartment_12045", "id": "reaction_10685764", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10685761", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10721465": { "compartment": "compartment_70101", "id": "reaction_10721465", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721443", "species_10721445", "species_10721450" ], "products": [ "species_10721452" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10670813": { "compartment": "compartment_7660", "id": "reaction_10670813", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10670825": { "compartment": "compartment_7660", "id": "reaction_10670825", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10670792": { "compartment": "compartment_70101", "id": "reaction_10670792", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670790" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10696253": { "compartment": "compartment_161320", "id": "reaction_10696253", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10724755": { "compartment": "compartment_161320", "id": "reaction_10724755", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10710763": { "compartment": "compartment_7660", "id": "reaction_10710763", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710740", "species_10669917" ], "products": [ "species_10710760" ], "modifiers": [ [ "species_10710740", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710800": { "compartment": "compartment_7660", "id": "reaction_10710800", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710791", "species_113518" ], "products": [ "species_10710797", "species_10669917" ], "modifiers": [ [ "species_10710791", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10710717": { "compartment": "compartment_7660", "id": "reaction_10710717", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10672165", "species_5688114" ], "products": [ "species_10710715" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54R66", "DDB_G0283365", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710742": { "compartment": "compartment_7660", "id": "reaction_10710742", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710738", "species_10710729" ], "products": [ "species_10709642", "species_10710740" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q551N8", "DDB_G0276481", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710744": { "compartment": "compartment_7660", "id": "reaction_10710744", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710727", "species_10710719" ], "products": [ "species_10710729" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710722": { "compartment": "compartment_7660", "id": "reaction_10710722", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10710715" ], "products": [ "species_10710719", "species_113541" ], "modifiers": [ [ "species_10710715", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10683780": { "compartment": "compartment_70101", "id": "reaction_10683780", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_29372", "species_10683777" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10722650": { "compartment": "compartment_984", "id": "reaction_10722650", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10722647", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10684783": { "compartment": "compartment_876", "id": "reaction_10684783", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10684780", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "Q559N7", "DDB_G0272550", "Q559I6", "DDB_G0272550", "Q55G06", "DDB_G0272550" ] }, "reaction_10724565": { "compartment": "compartment_7660", "id": "reaction_10724565", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10724563": { "compartment": "compartment_7660", "id": "reaction_10724563", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674840" ], "products": [ "species_10674840", "species_164121", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10675549": { "compartment": "compartment_7660", "id": "reaction_10675549", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674909" ], "products": [ "species_10675547", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674983": { "compartment": "compartment_7660", "id": "reaction_10674983", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674840", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674868": { "compartment": "compartment_7660", "id": "reaction_10674868", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674862" ], "products": [ "species_10674866" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674878": { "compartment": "compartment_7660", "id": "reaction_10674878", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674866" ], "products": [ "species_10674874" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10676040": { "compartment": "compartment_7660", "id": "reaction_10676040", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10675547" ], "products": [ "species_113541", "species_10675584" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674911": { "compartment": "compartment_7660", "id": "reaction_10674911", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674880" ], "products": [ "species_10674193", "species_10674181", "species_113541", "species_10674110", "species_10674909" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674876": { "compartment": "compartment_7660", "id": "reaction_10674876", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674874" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10683703": { "compartment": "compartment_17951", "id": "reaction_10683703", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683700", "catalyst" ] ], "additional_components": [ "Q55CT6", "DDB_G0288735", "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10683737": { "compartment": "compartment_17951", "id": "reaction_10683737", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683734", "catalyst" ] ], "additional_components": [ "B0G110", "DDB_G0288735", "Q54II1", "DDB_G0288735", "Q54RB0", "DDB_G0283261", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q75JL8", "DDB_G0288735", "species_113596" ] }, "reaction_10683740": { "compartment": "compartment_17951", "id": "reaction_10683740", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683742": { "compartment": "compartment_17951", "id": "reaction_10683742", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10693605": { "compartment": "compartment_70101", "id": "reaction_10693605", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693602", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10680017": { "compartment": "compartment_70101", "id": "reaction_10680017", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10671897": { "compartment": "compartment_70101", "id": "reaction_10671897", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671894", "species_29372" ], "products": [ "species_10671858", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10682008": { "compartment": "compartment_17960", "id": "reaction_10682008", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10675426", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671298": { "compartment": "compartment_5460", "id": "reaction_10671298", "reactome": "R-DDI-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671295", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10723508": { "compartment": "compartment_70101", "id": "reaction_10723508", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10673704": { "compartment": "compartment_70101", "id": "reaction_10673704", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_111627", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_29372", "species_111647" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10723971": { "compartment": "compartment_70101", "id": "reaction_10723971", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10712153": { "compartment": "compartment_70101", "id": "reaction_10712153", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10712150", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10684856": { "compartment": "compartment_70101", "id": "reaction_10684856", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10684853", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343" ] }, "reaction_10682020": { "compartment": "compartment_12045", "id": "reaction_10682020", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686707": { "compartment": "compartment_5460", "id": "reaction_10686707", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_30004" ], "products": [ "species_573404", "species_113526" ], "modifiers": [ [ "species_10671343", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10671725": { "compartment": "compartment_70101", "id": "reaction_10671725", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10671722", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10674017": { "compartment": "compartment_70101", "id": "reaction_10674017", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10698613": { "compartment": "compartment_70101", "id": "reaction_10698613", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698610", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10678886" ], "modifiers": [ [ "species_10698610", "catalyst" ] ], "additional_components": [ "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10711102": { "compartment": "compartment_70101", "id": "reaction_10711102", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671129": { "compartment": "compartment_5460", "id": "reaction_10671129", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10699261": { "compartment": "compartment_70101", "id": "reaction_10699261", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699205" ], "products": [ "species_110096", "species_10699258" ], "modifiers": [ [ "species_10699205", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10724003": { "compartment": "compartment_70101", "id": "reaction_10724003", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10673836": { "compartment": "compartment_70101", "id": "reaction_10673836", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10673833", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671521": { "compartment": "compartment_5460", "id": "reaction_10671521", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10671518", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10723948": { "compartment": "compartment_70101", "id": "reaction_10723948", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693658": { "compartment": "compartment_70101", "id": "reaction_10693658", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629739", "species_29356" ], "products": [ "species_1629753", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10723952": { "compartment": "compartment_70101", "id": "reaction_10723952", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679959": { "compartment": "compartment_70101", "id": "reaction_10679959", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_76194", "species_29370" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10677355": { "compartment": "compartment_70101", "id": "reaction_10677355", "reactome": "R-DDI-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10671760", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10693645": { "compartment": "compartment_70101", "id": "reaction_10693645", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10693642", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "species_29926", "Q54CH3", "DDB_G0292920" ] }, "reaction_10724042": { "compartment": "compartment_70101", "id": "reaction_10724042", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723997": { "compartment": "compartment_70101", "id": "reaction_10723997", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024012", "species_29368" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10693628": { "compartment": "compartment_7660", "id": "reaction_10693628", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10697783": { "compartment": "compartment_70101", "id": "reaction_10697783", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10696210": { "compartment": "compartment_70101", "id": "reaction_10696210", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10696207", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671658": { "compartment": "compartment_70101", "id": "reaction_10671658", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10671655", "catalyst" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10683688": { "compartment": "compartment_17951", "id": "reaction_10683688", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693703": { "compartment": "compartment_12045", "id": "reaction_10693703", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10693700", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "species_74016", "Q54K50", "DDB_G0287649", "Q02158", "DDB_G0292736" ] }, "reaction_10724425": { "compartment": "compartment_17963", "id": "reaction_10724425", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10716913": { "compartment": "compartment_17957", "id": "reaction_10716913", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10716907" ], "products": [ "species_10716911" ], "modifiers": [], "additional_components": [ "species_164991", "CHEBI:61907", "DDB_G0270658", "species_164991", "CHEBI:61907", "Q5FXM5", "DDB_G0270658" ] }, "reaction_10682071": { "compartment": "compartment_17960", "id": "reaction_10682071", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10699251": { "compartment": "compartment_70101", "id": "reaction_10699251", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699246" ], "products": [ "species_110096", "species_10699248" ], "modifiers": [ [ "species_10699246", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10723985": { "compartment": "compartment_70101", "id": "reaction_10723985", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10711963": { "compartment": "compartment_5460", "id": "reaction_10711963", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709959", "species_10711952" ], "products": [ "species_10711955", "species_10711950" ], "modifiers": [ [ "species_10711960", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10674313": { "compartment": "compartment_5460", "id": "reaction_10674313", "reactome": "R-DDI-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10671390": { "compartment": "compartment_70101", "id": "reaction_10671390", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10671387", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10714313": { "compartment": "compartment_70101", "id": "reaction_10714313", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799540", "species_29356" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10714310", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10722598": { "compartment": "compartment_70101", "id": "reaction_10722598", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10722595", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10675543": { "compartment": "compartment_12045", "id": "reaction_10675543", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686661": { "compartment": "compartment_5460", "id": "reaction_10686661", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113557" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10686658", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10709689": { "compartment": "compartment_70101", "id": "reaction_10709689", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10709686", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10721205": { "compartment": "compartment_5460", "id": "reaction_10721205", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721196", "species_10721184" ], "products": [ "species_10721182", "species_10721198" ], "modifiers": [ [ "species_10721203", "catalyst" ] ], "additional_components": [ "Q54P40", "DDB_G0284809", "Q54VS1", "DDB_G0280173", "CHEBI:33739", "Q555C8", "DDB_G0274657", "DDB_G0274657", "Q54P40", "DDB_G0284809", "CHEBI:49883", "Q54VS1", "DDB_G0280173", "DDB_G0280889" ] }, "reaction_10721413": { "compartment": "compartment_70101", "id": "reaction_10721413", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10721410", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10673730": { "compartment": "compartment_70101", "id": "reaction_10673730", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10673727", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10675882": { "compartment": "compartment_70101", "id": "reaction_10675882", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10675879", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10715965": { "compartment": "compartment_17951", "id": "reaction_10715965", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10715962", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10671413": { "compartment": "compartment_5460", "id": "reaction_10671413", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671410", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10724451": { "compartment": "compartment_17963", "id": "reaction_10724451", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10724448", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671288": { "compartment": "compartment_5460", "id": "reaction_10671288", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10671285", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10679946": { "compartment": "compartment_70101", "id": "reaction_10679946", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_196778", "species_111294" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10674328": { "compartment": "compartment_70101", "id": "reaction_10674328", "reactome": "R-DDI-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10674325", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10679969": { "compartment": "compartment_70101", "id": "reaction_10679969", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10679966", "catalyst" ] ], "additional_components": [ "Q54Y51", "DDB_G0278413", "species_76629" ] }, "reaction_10699233": { "compartment": "compartment_70101", "id": "reaction_10699233", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699228" ], "products": [ "species_110096", "species_10699230" ], "modifiers": [ [ "species_10699228", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10710929": { "compartment": "compartment_5460", "id": "reaction_10710929", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10710926", "catalyst" ] ], "additional_components": [ "species_113596", "Q86H28", "DDB_G0275669" ] }, "reaction_10686182": { "compartment": "compartment_70101", "id": "reaction_10686182", "reactome": "R-DDI-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686180" ], "products": [ "species_76577", "species_10671835" ], "modifiers": [], "additional_components": [ "species_76577", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123" ] }, "reaction_10693497": { "compartment": "compartment_70101", "id": "reaction_10693497", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10683752": { "compartment": "compartment_17951", "id": "reaction_10683752", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10714363": { "compartment": "compartment_70101", "id": "reaction_10714363", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10714360", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10680566": { "compartment": "compartment_70101", "id": "reaction_10680566", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10675479": { "compartment": "compartment_17960", "id": "reaction_10675479", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723977": { "compartment": "compartment_70101", "id": "reaction_10723977", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724007": { "compartment": "compartment_70101", "id": "reaction_10724007", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10721165": { "compartment": "compartment_5668575", "id": "reaction_10721165", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10721162", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10693637": { "compartment": "compartment_70101", "id": "reaction_10693637", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10684814": { "compartment": "compartment_70101", "id": "reaction_10684814", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10684811", "catalyst" ] ], "additional_components": [ "DDB_G0272883" ] }, "reaction_10693748": { "compartment": "compartment_17957", "id": "reaction_10693748", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_2564836", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10671078": { "compartment": "compartment_5460", "id": "reaction_10671078", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113559" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10671075", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10685049": { "compartment": "compartment_20699", "id": "reaction_10685049", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10685046", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10703426": { "compartment": "compartment_5668575", "id": "reaction_10703426", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ], [ "species_10703424", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901", "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10680347": { "compartment": "compartment_70101", "id": "reaction_10680347", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10671753": { "compartment": "compartment_70101", "id": "reaction_10671753", "reactome": "R-DDI-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10671750", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10726112": { "compartment": "compartment_70101", "id": "reaction_10726112", "reactome": "R-DDI-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671880": { "compartment": "compartment_70101", "id": "reaction_10671880", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671860" ], "products": [ "species_10671872" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10686823": { "compartment": "compartment_70101", "id": "reaction_10686823", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10686820", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680968": { "compartment": "compartment_876", "id": "reaction_10680968", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680926" ], "products": [ "species_10680966" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "Q55DU4", "DDB_G0270882", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10693648": { "compartment": "compartment_7660", "id": "reaction_10693648", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10675760": { "compartment": "compartment_70101", "id": "reaction_10675760", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10675757", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10671328": { "compartment": "compartment_5460", "id": "reaction_10671328", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10670934": { "compartment": "compartment_70101", "id": "reaction_10670934", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670857", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10673994": { "compartment": "compartment_70101", "id": "reaction_10673994", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10673991", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10709701": { "compartment": "compartment_70101", "id": "reaction_10709701", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10709698", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10695694": { "compartment": "compartment_17957", "id": "reaction_10695694", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10720506": { "compartment": "compartment_17927", "id": "reaction_10720506", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10720503", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10696226": { "compartment": "compartment_70101", "id": "reaction_10696226", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10696205", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10686641": { "compartment": "compartment_5460", "id": "reaction_10686641", "reactome": "R-DDI-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10686636", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10675638": { "compartment": "compartment_5460", "id": "reaction_10675638", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10681876": { "compartment": "compartment_984", "id": "reaction_10681876", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682157": { "compartment": "compartment_17960", "id": "reaction_10682157", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10682154", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_29926", "species_113596" ] }, "reaction_10721652": { "compartment": "compartment_70101", "id": "reaction_10721652", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10721649", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10684867": { "compartment": "compartment_70101", "id": "reaction_10684867", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10695696": { "compartment": "compartment_17957", "id": "reaction_10695696", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10723999": { "compartment": "compartment_70101", "id": "reaction_10723999", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10723957": { "compartment": "compartment_70101", "id": "reaction_10723957", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10695732": { "compartment": "compartment_17951", "id": "reaction_10695732", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10723050": { "compartment": "compartment_70101", "id": "reaction_10723050", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10723047", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671234": { "compartment": "compartment_70101", "id": "reaction_10671234", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_508182", "species_29406" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10671231", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10699196": { "compartment": "compartment_70101", "id": "reaction_10699196", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699191", "species_29410" ], "products": [ "species_110096", "species_10699193" ], "modifiers": [ [ "species_10699191", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10674368": { "compartment": "compartment_70101", "id": "reaction_10674368", "reactome": "R-DDI-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10724001": { "compartment": "compartment_70101", "id": "reaction_10724001", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10671162": { "compartment": "compartment_5460", "id": "reaction_10671162", "reactome": "R-DDI-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10671159", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10686188": { "compartment": "compartment_70101", "id": "reaction_10686188", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671907", "species_29372" ], "products": [ "species_10686186", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10679997": { "compartment": "compartment_70101", "id": "reaction_10679997", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10679994", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10723963": { "compartment": "compartment_70101", "id": "reaction_10723963", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693754": { "compartment": "compartment_7660", "id": "reaction_10693754", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10723967": { "compartment": "compartment_70101", "id": "reaction_10723967", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10677343": { "compartment": "compartment_7660", "id": "reaction_10677343", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10677337" ], "products": [ "species_10677341" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "species_76577", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683676": { "compartment": "compartment_17951", "id": "reaction_10683676", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10683673", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10686149": { "compartment": "compartment_5460", "id": "reaction_10686149", "reactome": "R-DDI-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113521", "species_113588" ], "modifiers": [ [ "species_10671466", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10690281": { "compartment": "compartment_70101", "id": "reaction_10690281", "reactome": "R-DDI-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10690061", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10711007": { "compartment": "compartment_70101", "id": "reaction_10711007", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247904", "species_1247942" ], "modifiers": [ [ "species_10711004", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10681902": { "compartment": "compartment_984", "id": "reaction_10681902", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10695730": { "compartment": "compartment_17951", "id": "reaction_10695730", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683611": { "compartment": "compartment_17947", "id": "reaction_10683611", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_76577", "species_389573" ], "modifiers": [ [ "species_10683608", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10695728": { "compartment": "compartment_17951", "id": "reaction_10695728", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10676860": { "compartment": "compartment_17957", "id": "reaction_10676860", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10688234": { "compartment": "compartment_70101", "id": "reaction_10688234", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10702349": { "compartment": "compartment_70101", "id": "reaction_10702349", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10702346", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "Q54VU3", "DDB_G0280135", "species_74126", "species_29926" ] }, "reaction_10675481": { "compartment": "compartment_17957", "id": "reaction_10675481", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10683691": { "compartment": "compartment_17951", "id": "reaction_10683691", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693572": { "compartment": "compartment_70101", "id": "reaction_10693572", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10710360": { "compartment": "compartment_12045", "id": "reaction_10710360", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10710357", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10695709": { "compartment": "compartment_12045", "id": "reaction_10695709", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046059", "species_2046066", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046057" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10679396": { "compartment": "compartment_70101", "id": "reaction_10679396", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10681911": { "compartment": "compartment_984", "id": "reaction_10681911", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682079": { "compartment": "compartment_17960", "id": "reaction_10682079", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10682076", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723983": { "compartment": "compartment_70101", "id": "reaction_10723983", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10724034": { "compartment": "compartment_70101", "id": "reaction_10724034", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10681891": { "compartment": "compartment_70101", "id": "reaction_10681891", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10681888", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10681909": { "compartment": "compartment_984", "id": "reaction_10681909", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10696183": { "compartment": "compartment_12045", "id": "reaction_10696183", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723085": { "compartment": "compartment_5460", "id": "reaction_10723085", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723082", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10721602": { "compartment": "compartment_12045", "id": "reaction_10721602", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10677038", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10698339": { "compartment": "compartment_70101", "id": "reaction_10698339", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698337" ], "products": [ "species_111294", "species_10674851", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10726109": { "compartment": "compartment_70101", "id": "reaction_10726109", "reactome": "R-DDI-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10719211": { "compartment": "compartment_70101", "id": "reaction_10719211", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10723061": { "compartment": "compartment_5460", "id": "reaction_10723061", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29376", "species_29362", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723058", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671715": { "compartment": "compartment_70101", "id": "reaction_10671715", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10671712", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10686653": { "compartment": "compartment_70101", "id": "reaction_10686653", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10686650", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671318": { "compartment": "compartment_5460", "id": "reaction_10671318", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10671315", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10693615": { "compartment": "compartment_70101", "id": "reaction_10693615", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10693612", "catalyst" ] ], "additional_components": [ "Q54N49", "DDB_G0285505", "species_29360" ] }, "reaction_10688232": { "compartment": "compartment_70101", "id": "reaction_10688232", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10698532": { "compartment": "compartment_70101", "id": "reaction_10698532", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3000241" ], "products": [ "species_29366", "species_10698529" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10723981": { "compartment": "compartment_70101", "id": "reaction_10723981", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671400": { "compartment": "compartment_5460", "id": "reaction_10671400", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10682460": { "compartment": "compartment_984", "id": "reaction_10682460", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10671191": { "compartment": "compartment_70101", "id": "reaction_10671191", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10671188", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10698522": { "compartment": "compartment_984", "id": "reaction_10698522", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10698519", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10697451": { "compartment": "compartment_70101", "id": "reaction_10697451", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357707", "species_29356" ], "products": [ "species_5357652", "species_111294", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10696223": { "compartment": "compartment_70101", "id": "reaction_10696223", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10696220", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10700265": { "compartment": "compartment_5460", "id": "reaction_10700265", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29444", "species_29582" ], "modifiers": [ [ "species_10700262", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10693640": { "compartment": "compartment_17957", "id": "reaction_10693640", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2024002", "species_113519" ], "products": [ "species_2024016", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10710309": { "compartment": "compartment_12045", "id": "reaction_10710309", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10710306", "catalyst" ] ], "additional_components": [ "Q54K22", "DDB_G0287631", "species_29926" ] }, "reaction_10673698": { "compartment": "compartment_70101", "id": "reaction_10673698", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111628" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10700271": { "compartment": "compartment_70101", "id": "reaction_10700271", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10700269" ], "products": [ "species_111294", "species_76577", "species_10680480" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10723954": { "compartment": "compartment_70101", "id": "reaction_10723954", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10720818": { "compartment": "compartment_70101", "id": "reaction_10720818", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10680482", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10698619": { "compartment": "compartment_70101", "id": "reaction_10698619", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10678890" ], "products": [ "species_111355", "species_10678886" ], "modifiers": [ [ "species_10678890", "catalyst" ] ], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260" ] }, "reaction_10682098": { "compartment": "compartment_12045", "id": "reaction_10682098", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682458": { "compartment": "compartment_70101", "id": "reaction_10682458", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10682455", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10680568": { "compartment": "compartment_70616", "id": "reaction_10680568", "reactome": "R-DDI-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10680551", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10679324": { "compartment": "compartment_17927", "id": "reaction_10679324", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189411", "species_189461" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10679321", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10691612": { "compartment": "compartment_70101", "id": "reaction_10691612", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_1474179" ], "products": [ "species_29366", "species_29870" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10696267": { "compartment": "compartment_5460", "id": "reaction_10696267", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162256", "species_2162257" ], "products": [ "species_2162214", "species_159450" ], "modifiers": [ [ "species_10696264", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10682136": { "compartment": "compartment_17960", "id": "reaction_10682136", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10682133", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10680561": { "compartment": "compartment_5460", "id": "reaction_10680561", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10680558", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10724013": { "compartment": "compartment_70101", "id": "reaction_10724013", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10695777": { "compartment": "compartment_161320", "id": "reaction_10695777", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10684878": { "compartment": "compartment_70101", "id": "reaction_10684878", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10686902": { "compartment": "compartment_20699", "id": "reaction_10686902", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10686899", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10671498": { "compartment": "compartment_5460", "id": "reaction_10671498", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10671495", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120", "species_113596" ] }, "reaction_10696163": { "compartment": "compartment_70101", "id": "reaction_10696163", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:34784", "species_8942209", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10672066": { "compartment": "compartment_70101", "id": "reaction_10672066", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10672063", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q551Y6", "DDB_G0276253", "Q54SI2", "DDB_G0282759" ] }, "reaction_10671912": { "compartment": "compartment_70101", "id": "reaction_10671912", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671872" ], "products": [ "species_10671909", "species_70113" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10671745": { "compartment": "compartment_70101", "id": "reaction_10671745", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10672030": { "compartment": "compartment_5460", "id": "reaction_10672030", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10672027", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10682478": { "compartment": "compartment_70101", "id": "reaction_10682478", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10682475", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10692500": { "compartment": "compartment_161320", "id": "reaction_10692500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10675875": { "compartment": "compartment_70101", "id": "reaction_10675875", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "species_109395", "species_76577", "CHEBI:57566", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10677058": { "compartment": "compartment_17957", "id": "reaction_10677058", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714825": { "compartment": "compartment_5460", "id": "reaction_10714825", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10674952": { "compartment": "compartment_70101", "id": "reaction_10674952", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10674947", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10686709": { "compartment": "compartment_5460", "id": "reaction_10686709", "reactome": "R-DDI-508561", "name": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_70951" ], "products": [ "species_113594", "species_508531" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10722779": { "compartment": "compartment_70101", "id": "reaction_10722779", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10697437": { "compartment": "compartment_5460", "id": "reaction_10697437", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697433", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10697431" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "Q54KG7", "DDB_G0287353", "species_31649" ] }, "reaction_10718732": { "compartment": "compartment_7660", "id": "reaction_10718732", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10718729", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_29426", "B0G107", "DDB_G0272484" ] }, "reaction_10678919": { "compartment": "compartment_70101", "id": "reaction_10678919", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10678916", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_29926", "Q54E83", "DDB_G0291756" ] }, "reaction_10693477": { "compartment": "compartment_70101", "id": "reaction_10693477", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693474", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q54TI0", "DDB_G0281737", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10680035": { "compartment": "compartment_70101", "id": "reaction_10680035", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10680032", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10674320": { "compartment": "compartment_5460", "id": "reaction_10674320", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500224", "species_113593" ], "products": [ "species_500222", "species_113581" ], "modifiers": [ [ "species_10674317", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_9731659", "species_109386", "Q54YL2", "DDB_G0278191" ] }, "reaction_10695691": { "compartment": "compartment_12045", "id": "reaction_10695691", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10724428": { "compartment": "compartment_17963", "id": "reaction_10724428", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10684911": { "compartment": "compartment_70101", "id": "reaction_10684911", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10680200": { "compartment": "compartment_876", "id": "reaction_10680200", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10680197", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10693588": { "compartment": "compartment_7660", "id": "reaction_10693588", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10693585", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10723989": { "compartment": "compartment_70101", "id": "reaction_10723989", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676821": { "compartment": "compartment_70101", "id": "reaction_10676821", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500606", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500608" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710344": { "compartment": "compartment_5460", "id": "reaction_10710344", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10710341", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10723965": { "compartment": "compartment_70101", "id": "reaction_10723965", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_29364", "species_9024768" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676025": { "compartment": "compartment_70101", "id": "reaction_10676025", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10673723", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10721370": { "compartment": "compartment_70101", "id": "reaction_10721370", "reactome": "R-DDI-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73473", "species_70106", "species_8936443" ], "products": [ "species_29360", "species_29468", "species_29356" ], "modifiers": [ [ "species_10721367", "catalyst" ] ], "additional_components": [ "Q8MYE6", "DDB_G0288165", "Q54YY9", "DDB_G0288165", "CHEBI:21437", "Q55D22", "DDB_G0288165", "Q54NC1", "DDB_G0285399", "Q54JB6", "DDB_G0288165" ] }, "reaction_10674006": { "compartment": "compartment_70101", "id": "reaction_10674006", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10674001", "catalyst" ], [ "species_10674004", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10670908": { "compartment": "compartment_70101", "id": "reaction_10670908", "reactome": "R-DDI-70355", "name": "GALK1 phosphorylates Gal to Gal1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29590" ], "products": [ "species_29370", "species_30170" ], "modifiers": [ [ "species_10670905", "catalyst" ] ], "additional_components": [ "DDB_G0293982" ] }, "reaction_10693763": { "compartment": "compartment_7660", "id": "reaction_10693763", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10724764": { "compartment": "compartment_70101", "id": "reaction_10724764", "reactome": "R-DDI-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10724761", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10710906": { "compartment": "compartment_17951", "id": "reaction_10710906", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10710903", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10680546": { "compartment": "compartment_70101", "id": "reaction_10680546", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10680543", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10677056": { "compartment": "compartment_17957", "id": "reaction_10677056", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10688530": { "compartment": "compartment_70101", "id": "reaction_10688530", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10688527", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10676802": { "compartment": "compartment_17957", "id": "reaction_10676802", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10676799", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10671798": { "compartment": "compartment_5460", "id": "reaction_10671798", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10680053": { "compartment": "compartment_70101", "id": "reaction_10680053", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10715958": { "compartment": "compartment_17951", "id": "reaction_10715958", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10715955", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10679114": { "compartment": "compartment_70101", "id": "reaction_10679114", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10679111", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10682726": { "compartment": "compartment_5460", "id": "reaction_10682726", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10682723", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10711203": { "compartment": "compartment_70101", "id": "reaction_10711203", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10711200", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10704741": { "compartment": "compartment_70101", "id": "reaction_10704741", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10704738", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10672020": { "compartment": "compartment_70101", "id": "reaction_10672020", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10672017", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10688136": { "compartment": "compartment_70101", "id": "reaction_10688136", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688120", "species_111707" ], "products": [ "species_10688125", "species_29432" ], "modifiers": [ [ "species_10688133", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "species_29426", "Q55FS0", "DDB_G0267980", "Q54X04", "DDB_G0279287" ] }, "reaction_10709886": { "compartment": "compartment_17957", "id": "reaction_10709886", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10709883", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10670844": { "compartment": "compartment_70101", "id": "reaction_10670844", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10670841", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759" ] }, "reaction_10672002": { "compartment": "compartment_5460", "id": "reaction_10672002", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10673770": { "compartment": "compartment_70101", "id": "reaction_10673770", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_29370", "species_500828" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "species_109395", "CHEBI:57566", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684957": { "compartment": "compartment_70101", "id": "reaction_10684957", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10722590": { "compartment": "compartment_12045", "id": "reaction_10722590", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10722587", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10676096": { "compartment": "compartment_70101", "id": "reaction_10676096", "reactome": "R-DDI-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676093", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10692454": { "compartment": "compartment_70101", "id": "reaction_10692454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10692451", "catalyst" ] ], "additional_components": [ "species_71185", "P46794", "DDB_G0267386" ] }, "reaction_10715520": { "compartment": "compartment_5460", "id": "reaction_10715520", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10715517", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10693661": { "compartment": "compartment_70101", "id": "reaction_10693661", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10686703": { "compartment": "compartment_5460", "id": "reaction_10686703", "reactome": "R-DDI-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10671265", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10723975": { "compartment": "compartment_70101", "id": "reaction_10723975", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10680223": { "compartment": "compartment_70101", "id": "reaction_10680223", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10680209" ], "products": [ "species_10680207", "species_198816" ], "modifiers": [ [ "species_10680209", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "species_71185", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185" ] }, "reaction_10717979": { "compartment": "compartment_161320", "id": "reaction_10717979", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10717976", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10675545": { "compartment": "compartment_17960", "id": "reaction_10675545", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724271": { "compartment": "compartment_161320", "id": "reaction_10724271", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724258", "species_1605715" ], "products": [ "species_10724262", "species_1605745" ], "modifiers": [ [ "species_10724268", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q55D50", "DDB_G0269790" ] }, "reaction_10720745": { "compartment": "compartment_70101", "id": "reaction_10720745", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10720742", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10692480": { "compartment": "compartment_70101", "id": "reaction_10692480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10674980": { "compartment": "compartment_70101", "id": "reaction_10674980", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10674977", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10722463": { "compartment": "compartment_70101", "id": "reaction_10722463", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10670855", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671252": { "compartment": "compartment_5460", "id": "reaction_10671252", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10671249", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10710331": { "compartment": "compartment_876", "id": "reaction_10710331", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10710328", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10679372": { "compartment": "compartment_5460", "id": "reaction_10679372", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_159549", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10679369", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10673780": { "compartment": "compartment_70101", "id": "reaction_10673780", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10673777", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10676863": { "compartment": "compartment_70101", "id": "reaction_10676863", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10673691": { "compartment": "compartment_70101", "id": "reaction_10673691", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10721497": { "compartment": "compartment_70101", "id": "reaction_10721497", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10682084": { "compartment": "compartment_17960", "id": "reaction_10682084", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10682081", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671096": { "compartment": "compartment_70101", "id": "reaction_10671096", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10671093", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10671707": { "compartment": "compartment_70101", "id": "reaction_10671707", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10671704", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10680536": { "compartment": "compartment_70101", "id": "reaction_10680536", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10688230": { "compartment": "compartment_70101", "id": "reaction_10688230", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10696171": { "compartment": "compartment_12045", "id": "reaction_10696171", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10675538", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10711236": { "compartment": "compartment_5460", "id": "reaction_10711236", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10711233", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0292730" ] }, "reaction_10723036": { "compartment": "compartment_5460", "id": "reaction_10723036", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10723033", "catalyst" ] ], "additional_components": [ "Q86I22", "DDB_G0275071", "species_29926" ] }, "reaction_10699305": { "compartment": "compartment_70101", "id": "reaction_10699305", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699303" ], "products": [ "species_10698514" ], "modifiers": [], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10695735": { "compartment": "compartment_17951", "id": "reaction_10695735", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10671459": { "compartment": "compartment_5460", "id": "reaction_10671459", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10671456", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10722403": { "compartment": "compartment_70101", "id": "reaction_10722403", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10722400", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "DDB_G0269034" ] }, "reaction_10686147": { "compartment": "compartment_5460", "id": "reaction_10686147", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10671446", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10683581": { "compartment": "compartment_17951", "id": "reaction_10683581", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10683578", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10724011": { "compartment": "compartment_70101", "id": "reaction_10724011", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026034" ], "products": [ "species_29364", "species_9026050" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724015": { "compartment": "compartment_70101", "id": "reaction_10724015", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_29364", "species_9026046" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10690348": { "compartment": "compartment_5460", "id": "reaction_10690348", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10690324", "species_10690337" ], "products": [ "species_10690345", "species_379697", "species_10690339" ], "modifiers": [ [ "species_10690324", "catalyst" ], [ "species_10690337", "catalyst" ] ], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "CHEBI:33739", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10693736": { "compartment": "compartment_876", "id": "reaction_10693736", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693733", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10721406": { "compartment": "compartment_70101", "id": "reaction_10721406", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_8938276" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10721403", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10725648": { "compartment": "compartment_70101", "id": "reaction_10725648", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10678991" ], "products": [ "species_10725644" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10693623": { "compartment": "compartment_7660", "id": "reaction_10693623", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10696160": { "compartment": "compartment_70101", "id": "reaction_10696160", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9032038" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10715539": { "compartment": "compartment_70101", "id": "reaction_10715539", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10715536", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10671308": { "compartment": "compartment_5460", "id": "reaction_10671308", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10682018": { "compartment": "compartment_12045", "id": "reaction_10682018", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10693580": { "compartment": "compartment_70101", "id": "reaction_10693580", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693577", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10688160": { "compartment": "compartment_70101", "id": "reaction_10688160", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10688157", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q54NM6", "DDB_G0285137" ] }, "reaction_10710887": { "compartment": "compartment_70101", "id": "reaction_10710887", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10710884", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10724005": { "compartment": "compartment_70101", "id": "reaction_10724005", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675640": { "compartment": "compartment_5460", "id": "reaction_10675640", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10687061": { "compartment": "compartment_5460", "id": "reaction_10687061", "reactome": "R-DDI-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10687058", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10685398": { "compartment": "compartment_876", "id": "reaction_10685398", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10685395", "catalyst" ] ], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10676087": { "compartment": "compartment_70101", "id": "reaction_10676087", "reactome": "R-DDI-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676084", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10684832": { "compartment": "compartment_70101", "id": "reaction_10684832", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10684819", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10680564": { "compartment": "compartment_70101", "id": "reaction_10680564", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10671362": { "compartment": "compartment_70101", "id": "reaction_10671362", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10671359", "catalyst" ] ], "additional_components": [ "DDB_G0273081" ] }, "reaction_10673986": { "compartment": "compartment_70101", "id": "reaction_10673986", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500071", "species_113592" ], "products": [ "species_500077", "species_29370" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "CHEBI:57673", "species_113578", "species_29420", "CHEBI:58595", "DDB_G0279001" ] }, "reaction_10674020": { "compartment": "compartment_70101", "id": "reaction_10674020", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10671380": { "compartment": "compartment_70101", "id": "reaction_10671380", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10671377", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10716922": { "compartment": "compartment_70101", "id": "reaction_10716922", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716918", "species_164991" ], "products": [ "species_10716920" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "species_164991", "Q54GC8", "DDB_G0290237" ] }, "reaction_10674856": { "compartment": "compartment_70101", "id": "reaction_10674856", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674853", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10710920": { "compartment": "compartment_70101", "id": "reaction_10710920", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10710917", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10671686": { "compartment": "compartment_70101", "id": "reaction_10671686", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10671683", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10724728": { "compartment": "compartment_17957", "id": "reaction_10724728", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10724725", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10671619": { "compartment": "compartment_70101", "id": "reaction_10671619", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10671616", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10714942": { "compartment": "compartment_70101", "id": "reaction_10714942", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10714939", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10671106": { "compartment": "compartment_5460", "id": "reaction_10671106", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "Q54KB7", "DDB_G0287469" ] }, "reaction_10693575": { "compartment": "compartment_70101", "id": "reaction_10693575", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10711211": { "compartment": "compartment_5460", "id": "reaction_10711211", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_6788606" ], "products": [ "species_113525", "species_5696409" ], "modifiers": [ [ "species_10711208", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10671608": { "compartment": "compartment_70101", "id": "reaction_10671608", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10671605", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10674301": { "compartment": "compartment_5460", "id": "reaction_10674301", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10674298", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10693708": { "compartment": "compartment_70101", "id": "reaction_10693708", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693705", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "species_29926" ] }, "reaction_10679054": { "compartment": "compartment_70101", "id": "reaction_10679054", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10679051", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:34479", "species_9753685", "CHEBI:8927", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54YN2", "DDB_G0278155", "Q54C73", "DDB_G0293122" ] }, "reaction_10671539": { "compartment": "compartment_5460", "id": "reaction_10671539", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10671536", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355" ] }, "reaction_10680025": { "compartment": "compartment_70101", "id": "reaction_10680025", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197238" ], "products": [ "species_113528", "species_111294", "species_197220" ], "modifiers": [ [ "species_10680022", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10683763": { "compartment": "compartment_17951", "id": "reaction_10683763", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10685044": { "compartment": "compartment_876", "id": "reaction_10685044", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10685041", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10725886": { "compartment": "compartment_70101", "id": "reaction_10725886", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10684851", "catalyst" ], [ "species_10725884", "inhibitor" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "LigandDisplayForward?ligandId=6625", "Q75JX1", "DDB_G0272350", "LigandDisplayForward?ligandId=10641", "Q86KF9", "DDB_G0272522", "LigandDisplayForward?ligandId=10219", "Q54HN2", "DDB_G0289343", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10687082": { "compartment": "compartment_5460", "id": "reaction_10687082", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_113552", "species_893617" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10725836": { "compartment": "compartment_70101", "id": "reaction_10725836", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674001", "species_9678719" ], "products": [ "species_10674004" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10686178": { "compartment": "compartment_5460", "id": "reaction_10686178", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10686175", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10676068": { "compartment": "compartment_70101", "id": "reaction_10676068", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10676065", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P21900", "DDB_G0285429", "species_29926" ] }, "reaction_10697789": { "compartment": "compartment_70101", "id": "reaction_10697789", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10710603": { "compartment": "compartment_5460", "id": "reaction_10710603", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10679344": { "compartment": "compartment_70101", "id": "reaction_10679344", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_113528", "species_189455" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10679938": { "compartment": "compartment_70101", "id": "reaction_10679938", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10679935", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10724017": { "compartment": "compartment_70101", "id": "reaction_10724017", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10686496": { "compartment": "compartment_70101", "id": "reaction_10686496", "reactome": "R-DDI-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_482627", "species_113592" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10674365": { "compartment": "compartment_70101", "id": "reaction_10674365", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_83956" ], "products": [ "species_30064", "species_31633" ], "modifiers": [ [ "species_10674362", "catalyst" ] ], "additional_components": [ "species_29426", "Q86AW9", "DDB_G0277743" ] }, "reaction_10696240": { "compartment": "compartment_5460", "id": "reaction_10696240", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10723961": { "compartment": "compartment_70101", "id": "reaction_10723961", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10680508": { "compartment": "compartment_7660", "id": "reaction_10680508", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10680505", "catalyst" ] ], "additional_components": [ "species_29426", "Q54IH4", "DDB_G0288757" ] }, "reaction_10671648": { "compartment": "compartment_70101", "id": "reaction_10671648", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10671645", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10687814": { "compartment": "compartment_876", "id": "reaction_10687814", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_71185", "species_29356" ], "products": [ "species_29370", "species_917877", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10723987": { "compartment": "compartment_70101", "id": "reaction_10723987", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024576" ], "products": [ "species_29364", "species_9024577" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675483": { "compartment": "compartment_17960", "id": "reaction_10675483", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696181": { "compartment": "compartment_70101", "id": "reaction_10696181", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142718" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10698333": { "compartment": "compartment_70101", "id": "reaction_10698333", "reactome": "R-DDI-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10698327", "species_113592" ], "products": [ "species_10698331", "species_111294", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "DDB_G0288791" ] }, "reaction_10693566": { "compartment": "compartment_17957", "id": "reaction_10693566", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10688246": { "compartment": "compartment_70101", "id": "reaction_10688246", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10690084": { "compartment": "compartment_70101", "id": "reaction_10690084", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10690081", "catalyst" ] ], "additional_components": [ "Q55FM6", "DDB_G0268036", "species_29926" ] }, "reaction_10675840": { "compartment": "compartment_70101", "id": "reaction_10675840", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10675837", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10680494": { "compartment": "compartment_70101", "id": "reaction_10680494", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680482", "species_113592" ], "products": [ "species_29370", "species_10680489" ], "modifiers": [ [ "species_10680491", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10671278": { "compartment": "compartment_5460", "id": "reaction_10671278", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10671275", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10671403": { "compartment": "compartment_5460", "id": "reaction_10671403", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10696251": { "compartment": "compartment_5460", "id": "reaction_10696251", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10684875": { "compartment": "compartment_70101", "id": "reaction_10684875", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025544", "species_29356" ], "products": [ "species_3632878", "species_428237" ], "modifiers": [ [ "species_10684872", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10675569": { "compartment": "compartment_70101", "id": "reaction_10675569", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10675566", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10680928": { "compartment": "compartment_70101", "id": "reaction_10680928", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751", "species_10680924" ], "products": [ "species_10680926" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10714820": { "compartment": "compartment_5460", "id": "reaction_10714820", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693984", "species_113526" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10714931": { "compartment": "compartment_17957", "id": "reaction_10714931", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806656", "species_6806362" ], "modifiers": [ [ "species_10714928", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10675642": { "compartment": "compartment_5460", "id": "reaction_10675642", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10678909": { "compartment": "compartment_70101", "id": "reaction_10678909", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10695699": { "compartment": "compartment_17957", "id": "reaction_10695699", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_162743", "species_2046065", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10671354": { "compartment": "compartment_5460", "id": "reaction_10671354", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671351", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10673701": { "compartment": "compartment_70101", "id": "reaction_10673701", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_111647" ], "products": [ "species_70106", "species_29372", "species_111628" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10673688": { "compartment": "compartment_70101", "id": "reaction_10673688", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10680051": { "compartment": "compartment_70101", "id": "reaction_10680051", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10722428": { "compartment": "compartment_5460", "id": "reaction_10722428", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113553", "species_113559" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10722425", "catalyst" ] ], "additional_components": [ "Q54BP5", "DDB_G0293514", "Q54IG0", "DDB_G0293514" ] }, "reaction_10687093": { "compartment": "compartment_70101", "id": "reaction_10687093", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10725642": { "compartment": "compartment_70101", "id": "reaction_10725642", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10680501": { "compartment": "compartment_5460", "id": "reaction_10680501", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10680498", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10698629": { "compartment": "compartment_5460", "id": "reaction_10698629", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10698626", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10696138": { "compartment": "compartment_984", "id": "reaction_10696138", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_352327", "species_109276" ], "products": [ "species_2160466", "species_2022135", "species_351629" ], "modifiers": [ [ "species_10696135", "catalyst" ] ], "additional_components": [ "Q54EW2", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B17", "DDB_G0293662", "species_113596", "Q55B19", "DDB_G0293662" ] }, "reaction_10723979": { "compartment": "compartment_70101", "id": "reaction_10723979", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679334": { "compartment": "compartment_17927", "id": "reaction_10679334", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10679331", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10671581": { "compartment": "compartment_70101", "id": "reaction_10671581", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10671578", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10690353": { "compartment": "compartment_5460", "id": "reaction_10690353", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690351", "species_113531" ], "products": [ "species_10690324" ], "modifiers": [], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003" ] }, "reaction_10690098": { "compartment": "compartment_70101", "id": "reaction_10690098", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10693526": { "compartment": "compartment_7660", "id": "reaction_10693526", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10711146": { "compartment": "compartment_17951", "id": "reaction_10711146", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10711143", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10699208": { "compartment": "compartment_70101", "id": "reaction_10699208", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699203", "species_29410" ], "products": [ "species_110096", "species_10699205" ], "modifiers": [ [ "species_10699203", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10709111": { "compartment": "compartment_5460", "id": "reaction_10709111", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10709108", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10703158": { "compartment": "compartment_17963", "id": "reaction_10703158", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10703155", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10712054": { "compartment": "compartment_70101", "id": "reaction_10712054", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10712051", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10693739": { "compartment": "compartment_876", "id": "reaction_10693739", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693673", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10693417": { "compartment": "compartment_161320", "id": "reaction_10693417", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105025", "species_1605715" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10699242": { "compartment": "compartment_70101", "id": "reaction_10699242", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699230" ], "products": [ "species_10699240" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10704832": { "compartment": "compartment_70101", "id": "reaction_10704832", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10691218", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10724243": { "compartment": "compartment_70101", "id": "reaction_10724243", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10671571": { "compartment": "compartment_5460", "id": "reaction_10671571", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10671568", "catalyst" ] ], "additional_components": [ "species_113596", "Q54R47", "DDB_G0283411" ] }, "reaction_10684954": { "compartment": "compartment_70101", "id": "reaction_10684954", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684951", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10679354": { "compartment": "compartment_70101", "id": "reaction_10679354", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_70106", "species_189464", "species_29356" ], "modifiers": [ [ "species_10679351", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10698535": { "compartment": "compartment_70101", "id": "reaction_10698535", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10687096": { "compartment": "compartment_70101", "id": "reaction_10687096", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10724430": { "compartment": "compartment_17963", "id": "reaction_10724430", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671336": { "compartment": "compartment_5460", "id": "reaction_10671336", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10671333", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10682091": { "compartment": "compartment_12045", "id": "reaction_10682091", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10681868": { "compartment": "compartment_70101", "id": "reaction_10681868", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10681865", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10688113": { "compartment": "compartment_70101", "id": "reaction_10688113", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10688110", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10690074": { "compartment": "compartment_70101", "id": "reaction_10690074", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10690071", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10671127": { "compartment": "compartment_70101", "id": "reaction_10671127", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10671124", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10699238": { "compartment": "compartment_70101", "id": "reaction_10699238", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699235" ], "products": [ "species_110096", "species_10699228" ], "modifiers": [ [ "species_10699235", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10703431": { "compartment": "compartment_5668572", "id": "reaction_10703431", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10671796": { "compartment": "compartment_5460", "id": "reaction_10671796", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10671793", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q54C70", "DDB_G0292994", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "P36413", "DDB_G0277847", "species_113596" ] }, "reaction_10674059": { "compartment": "compartment_5460", "id": "reaction_10674059", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10674056", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10709082": { "compartment": "compartment_70101", "id": "reaction_10709082", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10709079", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "C7G041", "DDB_G0295733" ] }, "reaction_10686145": { "compartment": "compartment_5462", "id": "reaction_10686145", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10686142", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10722332": { "compartment": "compartment_17963", "id": "reaction_10722332", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10722329", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10671932": { "compartment": "compartment_70101", "id": "reaction_10671932", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10671929", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_74126", "species_29926" ] }, "reaction_10680528": { "compartment": "compartment_70101", "id": "reaction_10680528", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10682074": { "compartment": "compartment_12045", "id": "reaction_10682074", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671151": { "compartment": "compartment_70101", "id": "reaction_10671151", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10671148", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q86HN8", "DDB_G0274501", "Q55E85", "DDB_G0269352" ] }, "reaction_10676819": { "compartment": "compartment_70101", "id": "reaction_10676819", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500605", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500607" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710913": { "compartment": "compartment_5460", "id": "reaction_10710913", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10710910", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10724046": { "compartment": "compartment_70101", "id": "reaction_10724046", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678893": { "compartment": "compartment_70101", "id": "reaction_10678893", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10678886" ], "products": [ "species_174390", "species_10678890" ], "modifiers": [ [ "species_10678886", "catalyst" ] ], "additional_components": [ "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10724009": { "compartment": "compartment_70101", "id": "reaction_10724009", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10683603": { "compartment": "compartment_17951", "id": "reaction_10683603", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10683600", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10703429": { "compartment": "compartment_5668572", "id": "reaction_10703429", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10684902": { "compartment": "compartment_70101", "id": "reaction_10684902", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275", "species_29356" ], "products": [ "species_428694", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10674338": { "compartment": "compartment_70101", "id": "reaction_10674338", "reactome": "R-DDI-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671372": { "compartment": "compartment_70101", "id": "reaction_10671372", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10671369", "catalyst" ] ], "additional_components": [ "Q86AX3", "DDB_G0277727", "species_29360" ] }, "reaction_10723950": { "compartment": "compartment_70101", "id": "reaction_10723950", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671172": { "compartment": "compartment_5460", "id": "reaction_10671172", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10671169", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10682291": { "compartment": "compartment_70101", "id": "reaction_10682291", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_265281", "species_29356" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10673806": { "compartment": "compartment_70101", "id": "reaction_10673806", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10673803", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10671561": { "compartment": "compartment_5460", "id": "reaction_10671561", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10720454": { "compartment": "compartment_70101", "id": "reaction_10720454", "reactome": "R-DDI-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720450" ], "products": [ "species_10720452" ], "modifiers": [], "additional_components": [ "species_8874708", "Q54YX3", "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10721392": { "compartment": "compartment_70101", "id": "reaction_10721392", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10721389", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10693651": { "compartment": "compartment_7660", "id": "reaction_10693651", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10699221": { "compartment": "compartment_70101", "id": "reaction_10699221", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699193" ], "products": [ "species_10699213" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10674042": { "compartment": "compartment_70101", "id": "reaction_10674042", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_113592", "species_111292" ], "products": [ "species_70106", "species_29370", "species_111338", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10697435": { "compartment": "compartment_5460", "id": "reaction_10697435", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690345", "species_10697431" ], "products": [ "species_10697433", "species_10690337", "species_113529" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54KG7", "DDB_G0287353", "species_31649", "Q54KG7", "DDB_G0287353", "species_113596", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10701681": { "compartment": "compartment_70101", "id": "reaction_10701681", "reactome": "R-DDI-5223313", "name": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239", "species_113592", "species_29356" ], "products": [ "species_29370", "species_3000241", "species_29372" ], "modifiers": [ [ "species_10701678", "catalyst" ] ], "additional_components": [ "Q54W20", "DDB_G0279919", "Q54KD1", "DDB_G0287405" ] }, "reaction_10714347": { "compartment": "compartment_161320", "id": "reaction_10714347", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10714344", "catalyst" ] ], "additional_components": [ "Q1ZXI8", "DDB_G0278651", "species_29426", "Q55ER0", "DDB_G0268994", "Q54KN4", "DDB_G0287231", "Q54YF7", "DDB_G0278259", "Q54YC4", "DDB_G0278653", "P34098", "DDB_G0292206" ] }, "reaction_10724753": { "compartment": "compartment_161320", "id": "reaction_10724753", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10682086": { "compartment": "compartment_12045", "id": "reaction_10682086", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671697": { "compartment": "compartment_70101", "id": "reaction_10671697", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10671694", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10679394": { "compartment": "compartment_70101", "id": "reaction_10679394", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10679351" ], "products": [ "species_29426", "species_10679392" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_190173" ] }, "reaction_10699256": { "compartment": "compartment_70101", "id": "reaction_10699256", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699253" ], "products": [ "species_10699191", "species_110096" ], "modifiers": [ [ "species_10699253", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10696176": { "compartment": "compartment_12045", "id": "reaction_10696176", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10696173", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724757": { "compartment": "compartment_161320", "id": "reaction_10724757", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10724423": { "compartment": "compartment_17963", "id": "reaction_10724423", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10724420", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10675485": { "compartment": "compartment_17960", "id": "reaction_10675485", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671513": { "compartment": "compartment_5460", "id": "reaction_10671513", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10671510", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10710932": { "compartment": "compartment_5460", "id": "reaction_10710932", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10696197": { "compartment": "compartment_70101", "id": "reaction_10696197", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10696194", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10678954": { "compartment": "compartment_17957", "id": "reaction_10678954", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174932" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10678951", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:32663", "CHEBI:63860", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714406": { "compartment": "compartment_12045", "id": "reaction_10714406", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10714399", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10684913": { "compartment": "compartment_70101", "id": "reaction_10684913", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10709894": { "compartment": "compartment_12045", "id": "reaction_10709894", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10709891", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10671086": { "compartment": "compartment_5460", "id": "reaction_10671086", "reactome": "R-DDI-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10671083", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "DDB_G0276335" ] }, "reaction_10716029": { "compartment": "compartment_17951", "id": "reaction_10716029", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10716026", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10674970": { "compartment": "compartment_70101", "id": "reaction_10674970", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10674967", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10685912": { "compartment": "compartment_5460", "id": "reaction_10685912", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10685909", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10690108": { "compartment": "compartment_70101", "id": "reaction_10690108", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10690105", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10682289": { "compartment": "compartment_70101", "id": "reaction_10682289", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10680220": { "compartment": "compartment_70101", "id": "reaction_10680220", "reactome": "R-DDI-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10680207" ], "products": [ "species_29360", "species_10680209" ], "modifiers": [ [ "species_10680217", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185", "Q54NC1", "DDB_G0285399", "species_113596" ] }, "reaction_10682255": { "compartment": "compartment_70101", "id": "reaction_10682255", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10712062": { "compartment": "compartment_5460", "id": "reaction_10712062", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10712059", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10687099": { "compartment": "compartment_70101", "id": "reaction_10687099", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10673790": { "compartment": "compartment_70101", "id": "reaction_10673790", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10673787", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10706110": { "compartment": "compartment_12045", "id": "reaction_10706110", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10706107", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10693680": { "compartment": "compartment_876", "id": "reaction_10693680", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693677", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10692503": { "compartment": "compartment_161320", "id": "reaction_10692503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10682468": { "compartment": "compartment_70101", "id": "reaction_10682468", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10724731": { "compartment": "compartment_17957", "id": "reaction_10724731", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677009", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10671242": { "compartment": "compartment_5460", "id": "reaction_10671242", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10671239", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10683593": { "compartment": "compartment_17951", "id": "reaction_10683593", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10683590", "catalyst" ] ], "additional_components": [ "species_29480", "Q54DA9", "DDB_G0292402", "species_29926" ] }, "reaction_10693745": { "compartment": "compartment_7660", "id": "reaction_10693745", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10671995": { "compartment": "compartment_70101", "id": "reaction_10671995", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10671992", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10671638": { "compartment": "compartment_70101", "id": "reaction_10671638", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10671635", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "species_71067", "species_198816", "Q557J8", "DDB_G0273429" ] }, "reaction_10698616": { "compartment": "compartment_70101", "id": "reaction_10698616", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3149505" ], "products": [ "species_29366", "species_10698529", "species_1130611" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10702271": { "compartment": "compartment_70101", "id": "reaction_10702271", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10719223": { "compartment": "compartment_70101", "id": "reaction_10719223", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10714960": { "compartment": "compartment_5460", "id": "reaction_10714960", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10714957", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10675877": { "compartment": "compartment_70101", "id": "reaction_10675877", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10687069": { "compartment": "compartment_5460", "id": "reaction_10687069", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687066", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10724039": { "compartment": "compartment_70101", "id": "reaction_10724039", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696186": { "compartment": "compartment_70101", "id": "reaction_10696186", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10688519": { "compartment": "compartment_70101", "id": "reaction_10688519", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10688516", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10674355": { "compartment": "compartment_70101", "id": "reaction_10674355", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83921", "CHEBI:17172", "CHEBI:16750", "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10674782": { "compartment": "compartment_70101", "id": "reaction_10674782", "reactome": "R-DDI-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10673675", "catalyst" ] ], "additional_components": [ "species_110096", "species_110094", "CHEBI:58593", "species_109395", "CHEBI:57566", "species_109402", "DDB_G0287495" ] }, "reaction_10724032": { "compartment": "compartment_70101", "id": "reaction_10724032", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10688148": { "compartment": "compartment_70101", "id": "reaction_10688148", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10688145", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10723969": { "compartment": "compartment_70101", "id": "reaction_10723969", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10696146": { "compartment": "compartment_70101", "id": "reaction_10696146", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10671969": { "compartment": "compartment_70101", "id": "reaction_10671969", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10680345": { "compartment": "compartment_876", "id": "reaction_10680345", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10680342", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10697786": { "compartment": "compartment_70101", "id": "reaction_10697786", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10687079": { "compartment": "compartment_70616", "id": "reaction_10687079", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687076", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10683622": { "compartment": "compartment_17951", "id": "reaction_10683622", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10683619", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10673846": { "compartment": "compartment_7660", "id": "reaction_10673846", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10673843", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10698355": { "compartment": "compartment_5460", "id": "reaction_10698355", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10698352", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10712045": { "compartment": "compartment_5460", "id": "reaction_10712045", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10671408", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10679382": { "compartment": "compartment_5460", "id": "reaction_10679382", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10679379", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10723088": { "compartment": "compartment_70101", "id": "reaction_10723088", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10701265", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10725646": { "compartment": "compartment_70101", "id": "reaction_10725646", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725644" ], "products": [ "species_189386", "species_10678991" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10723945": { "compartment": "compartment_70101", "id": "reaction_10723945", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020602", "species_29368" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678931": { "compartment": "compartment_70101", "id": "reaction_10678931", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10678928", "catalyst" ] ], "additional_components": [ "P10819", "DDB_G0267418", "species_29360" ] }, "reaction_10698646": { "compartment": "compartment_70101", "id": "reaction_10698646", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698608", "species_3149479" ], "products": [ "species_10698610" ], "modifiers": [], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10674028": { "compartment": "compartment_70101", "id": "reaction_10674028", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_70106", "species_29370", "species_111370", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680269": { "compartment": "compartment_70616", "id": "reaction_10680269", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10680266", "catalyst" ] ], "additional_components": [ "Q551X6", "DDB_G0276261", "Q54EV4", "DDB_G0291312", "Q54DU1", "DDB_G0292034", "Q54QI8", "DDB_G0283811", "Q54MZ4", "DDB_G0285599" ] }, "reaction_10719220": { "compartment": "compartment_70101", "id": "reaction_10719220", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10693757": { "compartment": "compartment_7660", "id": "reaction_10693757", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10722474": { "compartment": "compartment_70101", "id": "reaction_10722474", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10722471", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10724048": { "compartment": "compartment_70101", "id": "reaction_10724048", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671678": { "compartment": "compartment_70101", "id": "reaction_10671678", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10671675", "catalyst" ] ], "additional_components": [ "Q55DB4", "DDB_G0269714", "species_71185" ] }, "reaction_10682013": { "compartment": "compartment_12045", "id": "reaction_10682013", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10682010", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723991": { "compartment": "compartment_70101", "id": "reaction_10723991", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10702273": { "compartment": "compartment_70101", "id": "reaction_10702273", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78587", "CHEBI:78581", "Q54GA9", "DDB_G0290291" ] }, "reaction_10675822": { "compartment": "compartment_5460", "id": "reaction_10675822", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500822", "species_113593" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10675819", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_500742", "species_109366", "CHEBI:57566", "DDB_G0278191" ] }, "reaction_10719226": { "compartment": "compartment_70101", "id": "reaction_10719226", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10721331": { "compartment": "compartment_70616", "id": "reaction_10721331", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10721320" ], "products": [ "species_29374", "species_10721323" ], "modifiers": [ [ "species_10721328", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10682331": { "compartment": "compartment_70101", "id": "reaction_10682331", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10711938": { "compartment": "compartment_5460", "id": "reaction_10711938", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_10711922" ], "products": [ "species_10709959", "species_10711930" ], "modifiers": [ [ "species_10711935", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287107" ] }, "reaction_10671117": { "compartment": "compartment_5460", "id": "reaction_10671117", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10725639": { "compartment": "compartment_70101", "id": "reaction_10725639", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10703403": { "compartment": "compartment_5668572", "id": "reaction_10703403", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10703400", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10696248": { "compartment": "compartment_70616", "id": "reaction_10696248", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10696245", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10725998": { "compartment": "compartment_70101", "id": "reaction_10725998", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10725995", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10714822": { "compartment": "compartment_5460", "id": "reaction_10714822", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10684864": { "compartment": "compartment_70101", "id": "reaction_10684864", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "DDB_G0269738" ] }, "reaction_10674036": { "compartment": "compartment_70101", "id": "reaction_10674036", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10674033", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10698347": { "compartment": "compartment_5460", "id": "reaction_10698347", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10698344", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10696168": { "compartment": "compartment_12045", "id": "reaction_10696168", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10696165", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682321": { "compartment": "compartment_876", "id": "reaction_10682321", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10675770": { "compartment": "compartment_70101", "id": "reaction_10675770", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500201" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_109386", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684070": { "compartment": "compartment_876", "id": "reaction_10684070", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10684067", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10723505": { "compartment": "compartment_70101", "id": "reaction_10723505", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10683783": { "compartment": "compartment_17947", "id": "reaction_10683783", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10683481", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10679390": { "compartment": "compartment_70101", "id": "reaction_10679390", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10679387", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10699265": { "compartment": "compartment_70101", "id": "reaction_10699265", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699258" ], "products": [ "species_10699263" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10678959": { "compartment": "compartment_17957", "id": "reaction_10678959", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174911" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10678956", "catalyst" ] ], "additional_components": [ "CHEBI:16580", "species_211993", "species_29630", "species_159559", "species_39427", "CHEBI:32649", "species_158604", "CHEBI:65137", "CHEBI:176976", "CHEBI:64681", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10671668": { "compartment": "compartment_70101", "id": "reaction_10671668", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10671665", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10721317": { "compartment": "compartment_70101", "id": "reaction_10721317", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10721306", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10714397": { "compartment": "compartment_70101", "id": "reaction_10714397", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10715501": { "compartment": "compartment_13977", "id": "reaction_10715501", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10715498", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10711244": { "compartment": "compartment_7660", "id": "reaction_10711244", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10711241", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0278493" ] }, "reaction_10671068": { "compartment": "compartment_70101", "id": "reaction_10671068", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10671065", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10720456": { "compartment": "compartment_70101", "id": "reaction_10720456", "reactome": "R-DDI-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874708", "species_10720448" ], "products": [ "species_10720450" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10691374": { "compartment": "compartment_70101", "id": "reaction_10691374", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10691371", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10724050": { "compartment": "compartment_70101", "id": "reaction_10724050", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10723943": { "compartment": "compartment_70101", "id": "reaction_10723943", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10670918": { "compartment": "compartment_70101", "id": "reaction_10670918", "reactome": "R-DDI-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10670915", "catalyst" ] ], "additional_components": [ "Q553X7", "DDB_G0275295", "species_29360" ] }, "reaction_10709876": { "compartment": "compartment_17957", "id": "reaction_10709876", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10679064": { "compartment": "compartment_17957", "id": "reaction_10679064", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:27561", "species_159211", "CHEBI:2505", "species_9753685", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10709696": { "compartment": "compartment_12045", "id": "reaction_10709696", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10709693", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10714952": { "compartment": "compartment_5460", "id": "reaction_10714952", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10714949", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10688509": { "compartment": "compartment_17951", "id": "reaction_10688509", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10688506", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10693760": { "compartment": "compartment_70101", "id": "reaction_10693760", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_1629746", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10674382": { "compartment": "compartment_70101", "id": "reaction_10674382", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q54PM8", "DDB_G0284431" ] }, "reaction_10688244": { "compartment": "compartment_70101", "id": "reaction_10688244", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10680007": { "compartment": "compartment_70101", "id": "reaction_10680007", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10680004", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10698644": { "compartment": "compartment_70101", "id": "reaction_10698644", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10698641", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "Q54FB7", "DDB_G0291047", "species_113596" ] }, "reaction_10693548": { "compartment": "compartment_70101", "id": "reaction_10693548", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_1629741", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10715863": { "compartment": "compartment_17951", "id": "reaction_10715863", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10715860", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10684933": { "compartment": "compartment_984", "id": "reaction_10684933", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10684930", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10693569": { "compartment": "compartment_70101", "id": "reaction_10693569", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10720464": { "compartment": "compartment_5460", "id": "reaction_10720464", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10720461", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10684725": { "compartment": "compartment_876", "id": "reaction_10684725", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10684722", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10686646": { "compartment": "compartment_876", "id": "reaction_10686646", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10686643", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10675490": { "compartment": "compartment_12045", "id": "reaction_10675490", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10675487", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10674039": { "compartment": "compartment_70101", "id": "reaction_10674039", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_70106", "species_111354", "species_111355" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680570": { "compartment": "compartment_70101", "id": "reaction_10680570", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10680556": { "compartment": "compartment_70101", "id": "reaction_10680556", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10693664": { "compartment": "compartment_70101", "id": "reaction_10693664", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10680533": { "compartment": "compartment_876", "id": "reaction_10680533", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10680530", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10680239": { "compartment": "compartment_70101", "id": "reaction_10680239", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10680231" ], "products": [ "species_10674902", "species_158466" ], "modifiers": [ [ "species_10680236", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "DDB_G0285927" ] }, "reaction_10696179": { "compartment": "compartment_70101", "id": "reaction_10696179", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142738", "species_29368" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10670982": { "compartment": "compartment_70101", "id": "reaction_10670982", "reactome": "R-DDI-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10670979", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "P90521", "DDB_G0274111" ] }, "reaction_10680043": { "compartment": "compartment_70101", "id": "reaction_10680043", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10675644": { "compartment": "compartment_5460", "id": "reaction_10675644", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10674311": { "compartment": "compartment_5460", "id": "reaction_10674311", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10674308", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10682486": { "compartment": "compartment_70101", "id": "reaction_10682486", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10682483", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10670870": { "compartment": "compartment_70101", "id": "reaction_10670870", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10670867", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10671223": { "compartment": "compartment_5460", "id": "reaction_10671223", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10671220", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_29480", "Q54EW8", "DDB_G0291648", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_113596", "Q54M22", "DDB_G0286335" ] }, "reaction_10691385": { "compartment": "compartment_70101", "id": "reaction_10691385", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10691382", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10671441": { "compartment": "compartment_5460", "id": "reaction_10671441", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671438", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q54B68", "DDB_G0293872", "Q55BI2", "DDB_G0271344", "species_29418" ] }, "reaction_10702283": { "compartment": "compartment_70101", "id": "reaction_10702283", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10723959": { "compartment": "compartment_70101", "id": "reaction_10723959", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10683750": { "compartment": "compartment_17951", "id": "reaction_10683750", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10723973": { "compartment": "compartment_70101", "id": "reaction_10723973", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10682096": { "compartment": "compartment_12045", "id": "reaction_10682096", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682093", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10717974": { "compartment": "compartment_161320", "id": "reaction_10717974", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10717971", "catalyst" ] ], "additional_components": [ "species_29426", "P34098", "DDB_G0292206" ] }, "reaction_10698294": { "compartment": "compartment_70101", "id": "reaction_10698294", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698280" ], "products": [ "species_111294", "species_10698286", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10679956": { "compartment": "compartment_70101", "id": "reaction_10679956", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10679953", "catalyst" ] ], "additional_components": [ "Q55GR8", "DDB_G0267546", "species_29926" ] }, "reaction_10724025": { "compartment": "compartment_70101", "id": "reaction_10724025", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "CHEBI:137019", "CHEBI:137020", "CHEBI:137018", "CHEBI:137011", "DDB_G0279909" ] }, "reaction_10683754": { "compartment": "compartment_17951", "id": "reaction_10683754", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724044": { "compartment": "compartment_70101", "id": "reaction_10724044", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671591": { "compartment": "compartment_70101", "id": "reaction_10671591", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10671588", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10682470": { "compartment": "compartment_70101", "id": "reaction_10682470", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10699535": { "compartment": "compartment_7660", "id": "reaction_10699535", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_10699531" ], "products": [ "species_10699533" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10685442": { "compartment": "compartment_876", "id": "reaction_10685442", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10685439", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685527": { "compartment": "compartment_70101", "id": "reaction_10685527", "reactome": "R-DDI-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674709", "species_10684045" ], "products": [ "species_10685525" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10685468": { "compartment": "compartment_70101", "id": "reaction_10685468", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683907", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10674822": { "compartment": "compartment_13231", "id": "reaction_10674822", "reactome": "R-DDI-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674810" ], "products": [ "species_10674820" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10674828": { "compartment": "compartment_70101", "id": "reaction_10674828", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674826" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10674824": { "compartment": "compartment_13231", "id": "reaction_10674824", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674806" ], "products": [ "species_10674816" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10720815": { "compartment": "compartment_171062", "id": "reaction_10720815", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720749" ], "products": [ "species_10720472", "species_10720753", "species_29420" ], "modifiers": [ [ "species_10720812", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P34142", "DDB_G0286553", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PZ6", "DDB_G0284213", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721139": { "compartment": "compartment_5668575", "id": "reaction_10721139", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721116", "species_29438" ], "products": [ "species_10720472", "species_10721124", "species_29420" ], "modifiers": [ [ "species_10721136", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MXQ2", "DDB_G0275675", "Q55FM7", "DDB_G0268034", "Q54QR3", "DDB_G0283603", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "species_29438", "Q54QR3", "DDB_G0283603", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10720997": { "compartment": "compartment_17938", "id": "reaction_10720997", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720948" ], "products": [ "species_10720472", "species_10720978", "species_29420" ], "modifiers": [ [ "species_10720994", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q54IQ5", "DDB_G0288589", "Q54TG0", "DDB_G0281773" ] }, "reaction_10720737": { "compartment": "compartment_70101", "id": "reaction_10720737", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720721" ], "products": [ "species_10720472", "species_10720725", "species_29420" ], "modifiers": [ [ "species_10720734", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P36410", "DDB_G0281337", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10721062": { "compartment": "compartment_13946", "id": "reaction_10721062", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721005" ], "products": [ "species_10720472", "species_10721035", "species_29420" ], "modifiers": [ [ "species_10721059", "catalyst" ] ], "additional_components": [ "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q55FM7", "DDB_G0268034", "species_29420", "Q54VT9", "DDB_G0280143", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q54CV2", "DDB_G0292682", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q557G3", "DDB_G0273467", "Q54U24", "DDB_G0281351", "Q54RV6", "DDB_G0282887", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135" ] }, "reaction_10720645": { "compartment": "compartment_263163", "id": "reaction_10720645", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720638", "species_29438" ], "products": [ "species_10720642", "species_10720472", "species_29420" ], "modifiers": [ [ "species_10716880", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q55FK2", "DDB_G0268068", "Q55FM7", "DDB_G0268034", "Q55FK2", "DDB_G0268068", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10720634": { "compartment": "compartment_263163", "id": "reaction_10720634", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720551" ], "products": [ "species_10720472", "species_10720603", "species_29420" ], "modifiers": [ [ "species_10720631", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "species_29420", "P36411", "DDB_G0269236", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q55DD7", "DDB_G0270918", "Q54JA6", "DDB_G0288237" ] }, "reaction_10720942": { "compartment": "compartment_171062", "id": "reaction_10720942", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720880" ], "products": [ "species_10720472", "species_10720884", "species_29420" ], "modifiers": [ [ "species_10720939", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MYF2", "DDB_G0277441", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q8MYF2", "DDB_G0277441", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115" ] }, "reaction_10721156": { "compartment": "compartment_12045", "id": "reaction_10721156", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721143" ], "products": [ "species_10720472", "species_29420", "species_10721147" ], "modifiers": [ [ "species_10721153", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q54GY8", "DDB_G0289827", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10722918": { "compartment": "compartment_5460", "id": "reaction_10722918", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722910" ], "products": [], "modifiers": [ [ "species_10722915", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "Q55BQ4", "DDB_G0270806", "Q55CS9", "DDB_G0269916", "Q54U71", "DDB_G0281241", "Q37315", "DDB_G0294016", "DDB_G0271506" ] }, "reaction_10679142": { "compartment": "compartment_7660", "id": "reaction_10679142", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679123", "species_10679128", "species_10679133", "species_10679138" ], "products": [ "species_10679140" ], "modifiers": [], "additional_components": [ "DDB_G0289271", "DDB_G0293564", "DDB_G0291506", "DDB_G0269324", "Q55EA2", "DDB_G0269324", "Q54BL9", "DDB_G0293564", "Q54HR6", "DDB_G0289271", "Q54EH6", "DDB_G0291506" ] }, "reaction_10670519": { "compartment": "compartment_7660", "id": "reaction_10670519", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669631" ], "products": [ "species_10669627", "species_10669598", "species_10669622", "species_10669615" ], "modifiers": [], "additional_components": [ "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "DDB_G0292958", "DDB_G0286623", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10726207": { "compartment": "compartment_7660", "id": "reaction_10726207", "reactome": "R-DDI-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669598", "species_10669615" ], "products": [ "species_10669617" ], "modifiers": [], "additional_components": [ "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669566": { "compartment": "compartment_7660", "id": "reaction_10669566", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10669561" ], "products": [ "species_10669563", "species_10669557" ], "modifiers": [ [ "species_10669561", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670517": { "compartment": "compartment_70101", "id": "reaction_10670517", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670400" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726203": { "compartment": "compartment_7660", "id": "reaction_10726203", "reactome": "R-DDI-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669627", "species_10669622" ], "products": [ "species_10669629" ], "modifiers": [], "additional_components": [ "DDB_G0292958", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309" ] }, "reaction_10669568": { "compartment": "compartment_7660", "id": "reaction_10669568", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669559", "species_10669535" ], "products": [ "species_10669561" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10669647": { "compartment": "compartment_7660", "id": "reaction_10669647", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669573", "species_10669643" ], "products": [ "species_10669645" ], "modifiers": [], "additional_components": [ "DDB_G0267748", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q55GA4", "DDB_G0267748", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933" ] }, "reaction_10670368": { "compartment": "compartment_7660", "id": "reaction_10670368", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10669557" ], "products": [ "species_10669559" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670392": { "compartment": "compartment_7660", "id": "reaction_10670392", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669499" ], "products": [ "species_113582", "species_10670371" ], "modifiers": [ [ "species_10670389", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726144": { "compartment": "compartment_7660", "id": "reaction_10726144", "reactome": "R-DDI-9749215", "name": "MCM8 binds CDC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669506", "species_10669499" ], "products": [ "species_10669508" ], "modifiers": [], "additional_components": [ "DDB_G0283009", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10669949": { "compartment": "compartment_7660", "id": "reaction_10669949", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669659", "species_10669917" ], "products": [ "species_10669920" ], "modifiers": [ [ "species_10669946", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0283073", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629" ] }, "reaction_10669510": { "compartment": "compartment_7660", "id": "reaction_10669510", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC(1-6) at replication origins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669499", "species_10669492" ], "products": [ "species_10669501" ], "modifiers": [ [ "species_10669508", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q552L8", "DDB_G0275983", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10670515": { "compartment": "compartment_70101", "id": "reaction_10670515", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10670394", "species_113592" ], "products": [ "species_10670400" ], "modifiers": [ [ "species_10670512", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275983", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10670359": { "compartment": "compartment_70101", "id": "reaction_10670359", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669951" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726205": { "compartment": "compartment_7660", "id": "reaction_10726205", "reactome": "R-DDI-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669603", "species_10669613", "species_10669608" ], "products": [ "species_10669615" ], "modifiers": [], "additional_components": [ "DDB_G0275623", "DDB_G0282933", "DDB_G0272760", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669953": { "compartment": "compartment_7660", "id": "reaction_10669953", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669920" ], "products": [ "species_10669951" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10670364": { "compartment": "compartment_7660", "id": "reaction_10670364", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10669563", "species_29604", "species_29892" ], "products": [ "species_10670361" ], "modifiers": [ [ "species_10669535", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10726146": { "compartment": "compartment_7660", "id": "reaction_10726146", "reactome": "R-DDI-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669617", "species_10669629" ], "products": [ "species_10669631" ], "modifiers": [], "additional_components": [ "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669687": { "compartment": "compartment_7660", "id": "reaction_10669687", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669653" ], "products": [ "species_113582", "species_10669659", "species_10669663" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q54RU0", "DDB_G0282933", "Q54RN8", "DDB_G0283009", "DDB_G0283073", "Q54CP4", "DDB_G0292958", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10670396": { "compartment": "compartment_7660", "id": "reaction_10670396", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670371" ], "products": [ "species_10670394" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10682559": { "compartment": "compartment_13231", "id": "reaction_10682559", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682537" ], "products": [ "species_10682557" ], "modifiers": [], "additional_components": [ "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184", "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184" ] }, "reaction_10682346": { "compartment": "compartment_7660", "id": "reaction_10682346", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340", "species_29428" ], "products": [ "species_10682344" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10682565": { "compartment": "compartment_70101", "id": "reaction_10682565", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682561" ], "products": [ "species_10682563" ], "modifiers": [ [ "species_10682513", "catalyst" ] ], "additional_components": [ "DDB_G0277849", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10697851": { "compartment": "compartment_70101", "id": "reaction_10697851", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697839", "species_29356" ], "products": [ "species_10697849", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066" ] }, "reaction_10697883": { "compartment": "compartment_70101", "id": "reaction_10697883", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697849" ], "products": [ "species_29370", "species_10697839" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10702356": { "compartment": "compartment_876", "id": "reaction_10702356", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10702353", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10726153": { "compartment": "compartment_5460", "id": "reaction_10726153", "reactome": "R-DDI-9749971", "name": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_9750012", "species_113593" ], "products": [ "species_159448", "species_9749985", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10726183": { "compartment": "compartment_70101", "id": "reaction_10726183", "reactome": "R-DDI-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10726180", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54C73", "DDB_G0293122" ] }, "reaction_10726191": { "compartment": "compartment_70101", "id": "reaction_10726191", "reactome": "R-DDI-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10726188", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726193": { "compartment": "compartment_12045", "id": "reaction_10726193", "reactome": "R-DDI-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726151": { "compartment": "compartment_17957", "id": "reaction_10726151", "reactome": "R-DDI-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726156": { "compartment": "compartment_17957", "id": "reaction_10726156", "reactome": "R-DDI-9749977", "name": "UGT1A6 glucuronates ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_174384" ], "products": [ "species_158602", "species_9749997" ], "modifiers": [ [ "species_10677028", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726178": { "compartment": "compartment_70101", "id": "reaction_10726178", "reactome": "R-DDI-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10726175", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "Q86HQ2", "DDB_G0274117", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q54JR2", "DDB_G0287691", "Q8T686", "DDB_G0289655" ] }, "reaction_10726168": { "compartment": "compartment_70101", "id": "reaction_10726168", "reactome": "R-DDI-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10726165", "catalyst" ] ], "additional_components": [ "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726158": { "compartment": "compartment_17957", "id": "reaction_10726158", "reactome": "R-DDI-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726160": { "compartment": "compartment_17957", "id": "reaction_10726160", "reactome": "R-DDI-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726149": { "compartment": "compartment_17957", "id": "reaction_10726149", "reactome": "R-DDI-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10709871", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726197": { "compartment": "compartment_70101", "id": "reaction_10726197", "reactome": "R-DDI-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10696232": { "compartment": "compartment_70101", "id": "reaction_10696232", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10671976", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10677043": { "compartment": "compartment_70101", "id": "reaction_10677043", "reactome": "R-DDI-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10677040", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726186": { "compartment": "compartment_70101", "id": "reaction_10726186", "reactome": "R-DDI-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "DDB_G0285165" ] }, "reaction_10696229": { "compartment": "compartment_70101", "id": "reaction_10696229", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10726195": { "compartment": "compartment_70101", "id": "reaction_10726195", "reactome": "R-DDI-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10673891": { "compartment": "compartment_7660", "id": "reaction_10673891", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673887", "species_10673882" ], "products": [ "species_10673889" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q54HB0", "DDB_G0289587", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339" ] }, "reaction_10674680": { "compartment": "compartment_350", "id": "reaction_10674680", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10673976", "catalyst" ], [ "species_10674678", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54RQ4", "DDB_G0282987", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10673978": { "compartment": "compartment_7660", "id": "reaction_10673978", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673972" ], "products": [ "species_10673887", "species_10673976" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q54HB0", "DDB_G0289587", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "DDB_G0289587", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339" ] }, "reaction_10683664": { "compartment": "compartment_70101", "id": "reaction_10683664", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683658" ], "products": [ "species_10683660", "species_10683662" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705971": { "compartment": "compartment_70101", "id": "reaction_10705971", "reactome": "R-DDI-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705850" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10705961": { "compartment": "compartment_70101", "id": "reaction_10705961", "reactome": "R-DDI-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705931" ], "products": [ "species_10705959" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10709756": { "compartment": "compartment_7660", "id": "reaction_10709756", "reactome": "R-DDI-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705955", "species_10670747" ], "products": [ "species_10709754" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10705903": { "compartment": "compartment_70101", "id": "reaction_10705903", "reactome": "R-DDI-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705864", "species_113592" ], "products": [ "species_29370", "species_10705900" ], "modifiers": [ [ "species_10702686", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705968": { "compartment": "compartment_7660", "id": "reaction_10705968", "reactome": "R-DDI-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705959" ], "products": [ "species_10705931" ], "modifiers": [ [ "species_10705966", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "DDB_G0291306" ] }, "reaction_10685265": { "compartment": "compartment_876", "id": "reaction_10685265", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685262", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685272": { "compartment": "compartment_876", "id": "reaction_10685272", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685269", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685247": { "compartment": "compartment_876", "id": "reaction_10685247", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685249": { "compartment": "compartment_876", "id": "reaction_10685249", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10674798": { "compartment": "compartment_7660", "id": "reaction_10674798", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10724052": { "compartment": "compartment_70101", "id": "reaction_10724052", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674686" ], "products": [ "species_10674690" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10705346": { "compartment": "compartment_7660", "id": "reaction_10705346", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705342" ], "products": [ "species_10705344" ], "modifiers": [], "additional_components": [ "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10705349": { "compartment": "compartment_7660", "id": "reaction_10705349", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705344" ], "products": [ "species_113582", "species_10670822" ], "modifiers": [ [ "species_10705344", "catalyst" ] ], "additional_components": [ "Q54MH0", "DDB_G0285963", "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10674688": { "compartment": "compartment_7660", "id": "reaction_10674688", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10702591": { "compartment": "compartment_876", "id": "reaction_10702591", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10702588" ], "products": [ "species_29370", "species_10702566" ], "modifiers": [ [ "species_10683660", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10698157": { "compartment": "compartment_70101", "id": "reaction_10698157", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10676232", "species_10695461" ], "products": [ "species_10698131" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034" ] }, "reaction_10698155": { "compartment": "compartment_70101", "id": "reaction_10698155", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698135" ], "products": [ "species_10698153" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10702593": { "compartment": "compartment_876", "id": "reaction_10702593", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10678454" ], "products": [ "species_10702588" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996" ] }, "reaction_10702481": { "compartment": "compartment_70101", "id": "reaction_10702481", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10702478" ], "products": [ "species_10683047", "species_76183" ], "modifiers": [ [ "species_10701954", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "DDB_G0279267" ] }, "reaction_10706065": { "compartment": "compartment_17927", "id": "reaction_10706065", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10706055" ], "products": [ "species_5688340", "species_5688281", "species_10676517" ], "modifiers": [ [ "species_10706062", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10722767": { "compartment": "compartment_876", "id": "reaction_10722767", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722762" ], "products": [ "species_10722748", "species_29372" ], "modifiers": [ [ "species_10722762", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10676269": { "compartment": "compartment_70101", "id": "reaction_10676269", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10678297": { "compartment": "compartment_876", "id": "reaction_10678297", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678304": { "compartment": "compartment_876", "id": "reaction_10678304", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678285" ], "products": [ "species_29372", "species_10678299" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10722750": { "compartment": "compartment_876", "id": "reaction_10722750", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722748" ], "products": [ "species_10678290", "species_10722746" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10682978": { "compartment": "compartment_947587", "id": "reaction_10682978", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682971" ], "products": [ "species_29420", "species_10682975" ], "modifiers": [ [ "species_10682971", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_29438", "P36408", "DDB_G0277143", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349" ] }, "reaction_10678288": { "compartment": "compartment_876", "id": "reaction_10678288", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10678254" ], "products": [ "species_10678285" ], "modifiers": [ [ "species_10676221", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10678301": { "compartment": "compartment_876", "id": "reaction_10678301", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678299" ], "products": [ "species_10676221", "species_10678276" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10677642": { "compartment": "compartment_947587", "id": "reaction_10677642", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_29420" ], "products": [ "species_29438", "species_10676271" ], "modifiers": [ [ "species_10676139", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10722764": { "compartment": "compartment_876", "id": "reaction_10722764", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678270", "species_10722746" ], "products": [ "species_10722762" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10724973": { "compartment": "compartment_70101", "id": "reaction_10724973", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10679149", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10697954": { "compartment": "compartment_876", "id": "reaction_10697954", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10697951", "catalyst" ] ], "additional_components": [ "Q86I16", "DDB_G0275169", "Q54SN1", "DDB_G0282291", "Q55CU6", "DDB_G0275169" ] }, "reaction_10676383": { "compartment": "compartment_7660", "id": "reaction_10676383", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10676338", "species_10672161" ], "products": [ "species_10673970", "species_10676376" ], "modifiers": [ [ "species_10676338", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "DDB_G0271690", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0271690" ] }, "reaction_10676458": { "compartment": "compartment_7660", "id": "reaction_10676458", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676454" ], "products": [ "species_10676456" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676444": { "compartment": "compartment_7660", "id": "reaction_10676444", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676440" ], "products": [ "species_10673970", "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K42", "DDB_G0287661", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676466": { "compartment": "compartment_7660", "id": "reaction_10676466", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676376", "species_10676333" ], "products": [ "species_10676378" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676472": { "compartment": "compartment_7660", "id": "reaction_10676472", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676442" ], "products": [ "species_9757634", "species_10676454" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10697522": { "compartment": "compartment_70101", "id": "reaction_10697522", "reactome": "R-DDI-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473617", "species_10674488" ], "products": [ "species_10697520" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_5623649", "Q54YX3", "DDB_G0278031" ] }, "reaction_10697518": { "compartment": "compartment_70101", "id": "reaction_10697518", "reactome": "R-DDI-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674490", "species_200993" ], "products": [ "species_76194", "species_10697513" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "species_30927", "Q54YX3", "DDB_G0278031", "CHEBI:16254", "Q54YX3", "DDB_G0278031", "DDB_G0290279" ] }, "reaction_10676906": { "compartment": "compartment_7660", "id": "reaction_10676906", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676900" ], "products": [ "species_29370", "species_10676904" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10697578": { "compartment": "compartment_1598585", "id": "reaction_10697578", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697563" ], "products": [ "species_29370", "species_10697575" ], "modifiers": [ [ "species_10678756", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0274503" ] }, "reaction_10675117": { "compartment": "compartment_7660", "id": "reaction_10675117", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675051" ], "products": [ "species_10675115" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10725407": { "compartment": "compartment_876", "id": "reaction_10725407", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10704197" ], "products": [ "species_10704199" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10704211": { "compartment": "compartment_876", "id": "reaction_10704211", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704197" ], "products": [ "species_29370", "species_10704188" ], "modifiers": [ [ "species_10704197", "catalyst" ], [ "species_10704209", "inhibitor" ], [ "species_10704199", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10725409": { "compartment": "compartment_876", "id": "reaction_10725409", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657570" ], "products": [ "species_10704201" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385" ] }, "reaction_10725415": { "compartment": "compartment_876", "id": "reaction_10725415", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10704192" ], "products": [ "species_10725413" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9229", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P18160", "DDB_G0283385" ] }, "reaction_10725411": { "compartment": "compartment_876", "id": "reaction_10725411", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657574" ], "products": [ "species_10704195" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704203": { "compartment": "compartment_876", "id": "reaction_10704203", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704188" ], "products": [ "species_29370", "species_10704192" ], "modifiers": [ [ "species_10704188", "catalyst" ], [ "species_10704199", "inhibitor" ], [ "species_10704201", "inhibitor" ], [ "species_10704195", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704251": { "compartment": "compartment_74700", "id": "reaction_10704251", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704247" ], "products": [ "species_29370", "species_10704249" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833" ] }, "reaction_10700856": { "compartment": "compartment_7660", "id": "reaction_10700856", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_113671", "species_113685" ], "products": [ "species_10698653", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10699170": { "compartment": "compartment_7660", "id": "reaction_10699170", "reactome": "R-DDI-3318486", "name": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_113560" ], "products": [ "species_2485002", "species_10699149" ], "modifiers": [ [ "species_10699167", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10701877": { "compartment": "compartment_7660", "id": "reaction_10701877", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_77087" ], "products": [ "species_10696628", "species_77502" ], "modifiers": [ [ "species_10701874", "catalyst" ], [ "species_10701399", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q54MH6", "DDB_G0285847", "Q54IV4", "DDB_G0288495", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "O15819", "DDB_G0267402" ] }, "reaction_10703003": { "compartment": "compartment_7660", "id": "reaction_10703003", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702990", "species_77087" ], "products": [ "species_10702995", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10701096": { "compartment": "compartment_7660", "id": "reaction_10701096", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698653", "species_77502" ], "modifiers": [ [ "species_10701093", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q86A13", "DDB_G0287857", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132", "Q54J80", "DDB_G0288227" ] }, "reaction_10703010": { "compartment": "compartment_7660", "id": "reaction_10703010", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702995", "species_77087" ], "products": [ "species_10703008", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700971": { "compartment": "compartment_7660", "id": "reaction_10700971", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700828", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10701276": { "compartment": "compartment_7660", "id": "reaction_10701276", "reactome": "R-DDI-5205799", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698791", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ], [ "species_10701274", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "Q54NM0", "DDB_G0285205", "Q54WV6", "DDB_G0279373", "Q556Z0", "DDB_G0273203", "Q55C32", "DDB_G0285205", "Q54UQ7", "DDB_G0280887", "Q54KI3", "DDB_G0287327", "Q550R6", "DDB_G0277033" ] }, "reaction_10703386": { "compartment": "compartment_7660", "id": "reaction_10703386", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701268", "species_77087" ], "products": [ "species_10703384", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703018": { "compartment": "compartment_7660", "id": "reaction_10703018", "reactome": "R-DDI-5649802", "name": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10700861" ], "products": [ "species_77502", "species_10703016" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703368": { "compartment": "compartment_7660", "id": "reaction_10703368", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696628", "species_113685" ], "products": [ "species_159942", "species_10696623", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10702952": { "compartment": "compartment_7660", "id": "reaction_10702952", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700828", "species_77087" ], "products": [ "species_10702945", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10698670": { "compartment": "compartment_7660", "id": "reaction_10698670", "reactome": "R-DDI-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653" ], "products": [ "species_10698655", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10699592": { "compartment": "compartment_7660", "id": "reaction_10699592", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_113560" ], "products": [ "species_2485002", "species_10699570" ], "modifiers": [ [ "species_10699589", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q86J12", "DDB_G0274269", "Q54QW6", "DDB_G0283565" ] }, "reaction_10725840": { "compartment": "compartment_7660", "id": "reaction_10725840", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699922", "species_9679795" ], "products": [ "species_10699925" ], "modifiers": [], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "LigandDisplayForward?ligandId=7489", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10701685": { "compartment": "compartment_7660", "id": "reaction_10701685", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701663", "species_10701077" ], "products": [ "species_10701683" ], "modifiers": [], "additional_components": [ "O15819", "DDB_G0267402", "DDB_G0287273", "Q54KL5", "DDB_G0287273", "O15819", "DDB_G0267402" ] }, "reaction_10701512": { "compartment": "compartment_7660", "id": "reaction_10701512", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10701458" ], "products": [ "species_10701510", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "DDB_G0291556" ] }, "reaction_10701271": { "compartment": "compartment_7660", "id": "reaction_10701271", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_77087" ], "products": [ "species_10701268", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703381": { "compartment": "compartment_7660", "id": "reaction_10703381", "reactome": "R-DDI-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623" ], "products": [ "species_10698653", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10702931": { "compartment": "compartment_7660", "id": "reaction_10702931", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653", "species_77087" ], "products": [ "species_10696623", "species_77502" ], "modifiers": [ [ "species_10702928", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54IV4", "DDB_G0288495", "Q86A13", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703014": { "compartment": "compartment_7660", "id": "reaction_10703014", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10702990", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700840": { "compartment": "compartment_7660", "id": "reaction_10700840", "reactome": "R-DDI-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_113671", "species_113685" ], "products": [ "species_10700832", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10701689": { "compartment": "compartment_7660", "id": "reaction_10701689", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_10699587" ], "products": [ "species_10701687" ], "modifiers": [ [ "species_10701663", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "O15819", "DDB_G0267402", "Q54QW6", "DDB_G0283565", "O15819", "DDB_G0267402" ] }, "reaction_10703379": { "compartment": "compartment_7660", "id": "reaction_10703379", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10703016", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10700861" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10700873": { "compartment": "compartment_7660", "id": "reaction_10700873", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10700861", "species_113685" ], "products": [ "species_10700866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10699111": { "compartment": "compartment_7660", "id": "reaction_10699111", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696626", "species_113560" ], "products": [ "species_2485002", "species_10699070" ], "modifiers": [ [ "species_10699108", "catalyst" ] ], "additional_components": [ "DDB_G0267402", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10698695": { "compartment": "compartment_7660", "id": "reaction_10698695", "reactome": "R-DDI-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698686" ], "products": [ "species_10698692" ], "modifiers": [ [ "species_10698686", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10700892": { "compartment": "compartment_7660", "id": "reaction_10700892", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_77087" ], "products": [ "species_77502", "species_10700884" ], "modifiers": [ [ "species_10700889", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0289257" ] }, "reaction_10703012": { "compartment": "compartment_7660", "id": "reaction_10703012", "reactome": "R-DDI-5649800", "name": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700866", "species_77087" ], "products": [ "species_77502", "species_10700861" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703377": { "compartment": "compartment_7660", "id": "reaction_10703377", "reactome": "R-DDI-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10700884" ], "products": [ "species_10700830", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10703375": { "compartment": "compartment_7660", "id": "reaction_10703375", "reactome": "R-DDI-5661117", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698791", "species_77087" ], "products": [ "species_10703373", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10699927": { "compartment": "compartment_7660", "id": "reaction_10699927", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699922", "catalyst" ], [ "species_10699925", "inhibitor" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10702957": { "compartment": "compartment_7660", "id": "reaction_10702957", "reactome": "R-DDI-5638333", "name": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700866", "species_77502" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10699946": { "compartment": "compartment_7660", "id": "reaction_10699946", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699943", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10682182": { "compartment": "compartment_984", "id": "reaction_10682182", "reactome": "R-DDI-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10682179", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10682338": { "compartment": "compartment_876", "id": "reaction_10682338", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216762", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171095", "species_29372" ], "modifiers": [ [ "species_10682335", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10701034": { "compartment": "compartment_7660", "id": "reaction_10701034", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_29358" ], "products": [ "species_113582", "species_10701011" ], "modifiers": [ [ "species_10701031", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569" ] }, "reaction_10701013": { "compartment": "compartment_7660", "id": "reaction_10701013", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700995" ], "products": [ "species_10701001" ], "modifiers": [ [ "species_10701006", "catalyst" ], [ "species_10701011", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10684049": { "compartment": "compartment_70101", "id": "reaction_10684049", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10682591" ], "products": [ "species_10684047" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10687177": { "compartment": "compartment_70101", "id": "reaction_10687177", "reactome": "R-DDI-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10683990" ], "products": [ "species_10683995" ], "modifiers": [ [ "species_10687175", "inhibitor" ] ], "additional_components": [ "DDB_G0269138", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10684035": { "compartment": "compartment_70101", "id": "reaction_10684035", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10684031" ], "products": [ "species_10684033" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683997": { "compartment": "compartment_70101", "id": "reaction_10683997", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682591" ], "products": [ "species_10682593", "species_111294" ], "modifiers": [ [ "species_10683992", "catalyst" ], [ "species_10683995", "inhibitor" ] ], "additional_components": [ "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10675956": { "compartment": "compartment_7660", "id": "reaction_10675956", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675951" ], "products": [ "species_10675953", "species_110242" ], "modifiers": [ [ "species_10675951", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675977": { "compartment": "compartment_7660", "id": "reaction_10675977", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675972" ], "products": [ "species_10675974", "species_5635947" ], "modifiers": [ [ "species_10675972", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10711308": { "compartment": "compartment_984", "id": "reaction_10711308", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10711305", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10685610": { "compartment": "compartment_70101", "id": "reaction_10685610", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683631", "species_113592", "species_10676526" ], "products": [ "species_29370", "species_10683629", "species_10685607" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10687031": { "compartment": "compartment_876", "id": "reaction_10687031", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687023", "species_10687027" ], "products": [ "species_10687029" ], "modifiers": [], "additional_components": [ "DDB_G0287833", "species_1236719", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125", "species_1236719", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125" ] }, "reaction_10716012": { "compartment": "compartment_7660", "id": "reaction_10716012", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10716000" ], "products": [ "species_113582", "species_10716009" ], "modifiers": [ [ "species_10716000", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54FD6", "DDB_G0290929", "Q54KJ8", "DDB_G0287307", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131" ] }, "reaction_10676885": { "compartment": "compartment_7660", "id": "reaction_10676885", "reactome": "R-DDI-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676872" ], "products": [ "species_113582", "species_10676876" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10676923": { "compartment": "compartment_7660", "id": "reaction_10676923", "reactome": "R-DDI-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676918" ], "products": [ "species_113582", "species_10676921" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10726046": { "compartment": "compartment_70101", "id": "reaction_10726046", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721285", "species_9714134" ], "products": [ "species_10726044" ], "modifiers": [], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "Q54NZ5", "DDB_G0284903", "LigandDisplayForward?ligandId=6569", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10682925": { "compartment": "compartment_70101", "id": "reaction_10682925", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_9677992" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10682923": { "compartment": "compartment_70101", "id": "reaction_10682923", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362", "species_29368", "species_29356" ], "products": [ "species_29408", "species_9677997", "species_29382" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683515": { "compartment": "compartment_17947", "id": "reaction_10683515", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683513", "species_10683495" ], "products": [ "species_10683511", "species_10683487", "species_10683495" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213" ] }, "reaction_10691278": { "compartment": "compartment_70101", "id": "reaction_10691278", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10691275", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10704829": { "compartment": "compartment_984", "id": "reaction_10704829", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429802", "species_29356" ], "products": [ "species_29370", "species_382539", "species_29372" ], "modifiers": [ [ "species_10704826", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10691271": { "compartment": "compartment_70101", "id": "reaction_10691271", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10691268", "catalyst" ] ], "additional_components": [ "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10716905": { "compartment": "compartment_70101", "id": "reaction_10716905", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_113592", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10716902", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10705130": { "compartment": "compartment_70101", "id": "reaction_10705130", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10705127", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10682286": { "compartment": "compartment_876", "id": "reaction_10682286", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265784", "species_113592", "species_29356" ], "products": [ "species_29370", "species_265781", "species_29372" ], "modifiers": [ [ "species_10682283", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q55DW4", "DDB_G0269214" ] }, "reaction_10691341": { "compartment": "compartment_876", "id": "reaction_10691341", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131652", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1467459" ], "modifiers": [ [ "species_10691338", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54BU4", "DDB_G0293416", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T9W4", "DDB_G0291714", "Q8T9W1", "DDB_G0286123", "Q54RU1", "DDB_G0282931", "Q8T6J5", "DDB_G0267438", "Q54W24", "DDB_G0279915", "Q54R52", "DDB_G0283387", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438" ] }, "reaction_10683474": { "compartment": "compartment_70616", "id": "reaction_10683474", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10683471", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W2", "DDB_G0292554", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10701720": { "compartment": "compartment_70101", "id": "reaction_10701720", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10701716" ], "products": [ "species_10701718" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436", "Q869N9", "DDB_G0271862" ] }, "reaction_10690498": { "compartment": "compartment_876", "id": "reaction_10690498", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10690500": { "compartment": "compartment_876", "id": "reaction_10690500", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_171149", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10691362": { "compartment": "compartment_74000", "id": "reaction_10691362", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_2466098" ], "products": [ "species_29370", "species_975622", "species_29372" ], "modifiers": [ [ "species_10691359", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10683490": { "compartment": "compartment_17947", "id": "reaction_10683490", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10683487", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10677433": { "compartment": "compartment_70101", "id": "reaction_10677433", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10677430" ], "modifiers": [ [ "species_10675814", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10722655": { "compartment": "compartment_876", "id": "reaction_10722655", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722652" ], "products": [ "species_10679174", "species_10679153" ], "modifiers": [ [ "species_10722652", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10722657": { "compartment": "compartment_876", "id": "reaction_10722657", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679174", "species_10678454" ], "products": [ "species_10722652" ], "modifiers": [], "additional_components": [ "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10716950": { "compartment": "compartment_876", "id": "reaction_10716950", "reactome": "R-DDI-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10716947", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q55GR7", "DDB_G0267548", "Q54WH5", "DDB_G0279657", "Q54RS7", "DDB_G0282949", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54YW1", "DDB_G0278051", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54NW4", "DDB_G0284863" ] }, "reaction_10716247": { "compartment": "compartment_263163", "id": "reaction_10716247", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716238" ], "products": [ "species_10716244", "species_29420" ], "modifiers": [ [ "species_10716238", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716664": { "compartment": "compartment_263163", "id": "reaction_10716664", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716608", "species_10710119", "species_10710110" ], "products": [ "species_10716662" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716705": { "compartment": "compartment_263163", "id": "reaction_10716705", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716701", "species_10710119", "species_10710110" ], "products": [ "species_10716703" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716764": { "compartment": "compartment_263163", "id": "reaction_10716764", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716751", "species_10716762" ], "products": [ "species_10716753" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0278181", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716760": { "compartment": "compartment_263163", "id": "reaction_10716760", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716753" ], "products": [ "species_10716757" ], "modifiers": [ [ "species_10716753", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716424": { "compartment": "compartment_263163", "id": "reaction_10716424", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716420", "species_10716405" ], "products": [ "species_10716422" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716667": { "compartment": "compartment_263163", "id": "reaction_10716667", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716662", "species_113592" ], "products": [ "species_29370", "species_10716530", "species_10716540", "species_10710119", "species_10716596", "species_10710110", "species_10716532" ], "modifiers": [ [ "species_10716662", "catalyst" ] ], "additional_components": [ "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575", "DDB_G0284185", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0290363", "Q75JI3", "DDB_G0276153", "DDB_G0276575", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716407": { "compartment": "compartment_263163", "id": "reaction_10716407", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716399", "species_10716391" ], "products": [ "species_10716405" ], "modifiers": [], "additional_components": [ "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716240": { "compartment": "compartment_263163", "id": "reaction_10716240", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716220", "species_10716232" ], "products": [ "species_10716238" ], "modifiers": [], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716413": { "compartment": "compartment_263163", "id": "reaction_10716413", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716411", "species_10716381" ], "products": [ "species_10716391" ], "modifiers": [], "additional_components": [ "species_29438", "Q54QU7", "DDB_G0283631", "DDB_G0269368", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10721886": { "compartment": "compartment_70616", "id": "reaction_10721886", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10721883", "catalyst" ] ], "additional_components": [ "Q54LT0", "DDB_G0286429", "Q54JS1", "DDB_G0287825" ] }, "reaction_10685511": { "compartment": "compartment_876", "id": "reaction_10685511", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10685508", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10697358": { "compartment": "compartment_984", "id": "reaction_10697358", "reactome": "R-DDI-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697305" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696943": { "compartment": "compartment_984", "id": "reaction_10696943", "reactome": "R-DDI-2213210", "name": "Collagen IX is cross-linked to the surface of collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696939", "species_10691415" ], "products": [ "species_10696941" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10698054": { "compartment": "compartment_984", "id": "reaction_10698054", "reactome": "R-DDI-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_351629" ], "products": [ "species_10698047" ], "modifiers": [ [ "species_10698051", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q6TMK4", "DDB_G0277275", "CHEBI:15858" ] }, "reaction_10697211": { "compartment": "compartment_984", "id": "reaction_10697211", "reactome": "R-DDI-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697099" ], "products": [ "species_10697209" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696855": { "compartment": "compartment_984", "id": "reaction_10696855", "reactome": "R-DDI-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696849" ], "products": [ "species_10696853" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697334": { "compartment": "compartment_984", "id": "reaction_10697334", "reactome": "R-DDI-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10694584" ], "products": [ "species_10697099" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697103": { "compartment": "compartment_984", "id": "reaction_10697103", "reactome": "R-DDI-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10697099" ], "products": [ "species_10697101" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696859": { "compartment": "compartment_984", "id": "reaction_10696859", "reactome": "R-DDI-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696851", "species_10691415" ], "products": [ "species_10696857" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697360": { "compartment": "compartment_984", "id": "reaction_10697360", "reactome": "R-DDI-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697183" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697250": { "compartment": "compartment_984", "id": "reaction_10697250", "reactome": "R-DDI-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691593", "species_10691415" ], "products": [ "species_10697248" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697332": { "compartment": "compartment_984", "id": "reaction_10697332", "reactome": "R-DDI-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305" ], "products": [ "species_10697330" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697414": { "compartment": "compartment_984", "id": "reaction_10697414", "reactome": "R-DDI-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305", "species_10697099" ], "products": [ "species_10697412" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697166": { "compartment": "compartment_984", "id": "reaction_10697166", "reactome": "R-DDI-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694584", "species_10676611" ], "products": [ "species_10697164" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697387": { "compartment": "compartment_984", "id": "reaction_10697387", "reactome": "R-DDI-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697305" ], "products": [ "species_10697385" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696823": { "compartment": "compartment_984", "id": "reaction_10696823", "reactome": "R-DDI-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691599" ], "products": [ "species_10696821" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10691601": { "compartment": "compartment_984", "id": "reaction_10691601", "reactome": "R-DDI-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691589" ], "products": [ "species_10691599" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10676916": { "compartment": "compartment_7660", "id": "reaction_10676916", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670658" ], "products": [ "species_113582", "species_10676914" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0274503" ] }, "reaction_10676895": { "compartment": "compartment_7660", "id": "reaction_10676895", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676887" ], "products": [ "species_29370", "species_10676890" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10677114": { "compartment": "compartment_7660", "id": "reaction_10677114", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10677109" ], "products": [ "species_113582", "species_10677112" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0291842", "DDB_G0291842", "DDB_G0274503" ] }, "reaction_10697270": { "compartment": "compartment_984", "id": "reaction_10697270", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697266", "species_10695841" ], "products": [ "species_10697268" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485" ] }, "reaction_10695849": { "compartment": "compartment_984", "id": "reaction_10695849", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695819" ], "products": [ "species_10695847" ], "modifiers": [], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485" ] }, "reaction_10724643": { "compartment": "compartment_70101", "id": "reaction_10724643", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724639", "species_10676232" ], "products": [ "species_10724641" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10724634": { "compartment": "compartment_70101", "id": "reaction_10724634", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724627", "species_113592" ], "products": [ "species_29370", "species_10724631" ], "modifiers": [ [ "species_10724627", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10726201": { "compartment": "compartment_7660", "id": "reaction_10726201", "reactome": "R-DDI-9754130", "name": "CDK4 inhibitors bind CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9754127", "species_10670762" ], "products": [ "species_10670773" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680" ] }, "reaction_10723600": { "compartment": "compartment_7660", "id": "reaction_10723600", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698648", "species_10670680" ], "products": [ "species_10723598" ], "modifiers": [ [ "species_10670387", "inhibitor" ], [ "species_10670764", "inhibitor" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10721692": { "compartment": "compartment_7660", "id": "reaction_10721692", "reactome": "R-DDI-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10721688" ], "products": [ "species_113582", "species_10670764" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10670637": { "compartment": "compartment_70101", "id": "reaction_10670637", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670633", "species_10670619" ], "products": [ "species_10670635" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690366": { "compartment": "compartment_7660", "id": "reaction_10690366", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690027" ], "products": [ "species_113550", "species_10690019" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678594": { "compartment": "compartment_70101", "id": "reaction_10678594", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678224", "species_10670619" ], "products": [ "species_10678592" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10676508": { "compartment": "compartment_7660", "id": "reaction_10676508", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10676480", "species_113656" ], "products": [ "species_113550", "species_10676482" ], "modifiers": [ [ "species_10676505", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10670666": { "compartment": "compartment_7660", "id": "reaction_10670666", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_113582", "species_10670646" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10721690": { "compartment": "compartment_13231", "id": "reaction_10721690", "reactome": "R-DDI-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721670" ], "products": [ "species_10721688" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10678230": { "compartment": "compartment_13231", "id": "reaction_10678230", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678226" ], "products": [ "species_10678228" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10670783": { "compartment": "compartment_7660", "id": "reaction_10670783", "reactome": "R-DDI-69227", "name": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670680" ], "products": [ "species_113582", "species_10670683" ], "modifiers": [ [ "species_10670764", "catalyst" ], [ "species_10670773", "inhibitor" ], [ "species_10670781", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10698510": { "compartment": "compartment_70101", "id": "reaction_10698510", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676892" ], "products": [ "species_10676882" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10678242": { "compartment": "compartment_13231", "id": "reaction_10678242", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678238" ], "products": [ "species_10678240" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10679206": { "compartment": "compartment_7660", "id": "reaction_10679206", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679202", "species_10669684" ], "products": [ "species_10679204" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10717991": { "compartment": "compartment_70101", "id": "reaction_10717991", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717986" ], "products": [ "species_10670153", "species_10717891" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10718380": { "compartment": "compartment_7660", "id": "reaction_10718380", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718364" ], "products": [ "species_10690363", "species_8857797" ], "modifiers": [ [ "species_10718377", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0281651" ] }, "reaction_10696428": { "compartment": "compartment_7660", "id": "reaction_10696428", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696414", "species_29358" ], "products": [ "species_113582", "species_10696417" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10678234": { "compartment": "compartment_13231", "id": "reaction_10678234", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676890" ], "products": [ "species_10678232" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10697660": { "compartment": "compartment_7660", "id": "reaction_10697660", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697640", "species_113560" ], "products": [ "species_2485002", "species_10697648" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10690017": { "compartment": "compartment_7660", "id": "reaction_10690017", "reactome": "R-DDI-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_29358" ], "products": [ "species_113582", "species_10690015", "species_10690013" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726199": { "compartment": "compartment_7660", "id": "reaction_10726199", "reactome": "R-DDI-9754129", "name": "CDK6 inhibitors bind CDK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670751", "species_9754132" ], "products": [ "species_10670781" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10717895": { "compartment": "compartment_70101", "id": "reaction_10717895", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678761", "species_10717891" ], "products": [ "species_10717893" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10679247": { "compartment": "compartment_7660", "id": "reaction_10679247", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_10670387", "species_113582" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10677004": { "compartment": "compartment_13231", "id": "reaction_10677004", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670635" ], "products": [ "species_10670641" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10717989": { "compartment": "compartment_70101", "id": "reaction_10717989", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10717893" ], "products": [ "species_10717986" ], "modifiers": [ [ "species_10717893", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10690392": { "compartment": "compartment_7660", "id": "reaction_10690392", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679187", "species_10690013" ], "products": [ "species_10690390" ], "modifiers": [], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "DDB_G0290551", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10690031": { "compartment": "compartment_7660", "id": "reaction_10690031", "reactome": "R-DDI-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10690021" ], "products": [ "species_113582", "species_10690027", "species_10690029" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679253": { "compartment": "compartment_7660", "id": "reaction_10679253", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670387", "species_10670683" ], "products": [ "species_10679251" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679256": { "compartment": "compartment_7660", "id": "reaction_10679256", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679251" ], "products": [ "species_113582", "species_10670387", "species_10676480" ], "modifiers": [ [ "species_10679251", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10697703": { "compartment": "compartment_7660", "id": "reaction_10697703", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697699", "species_113560" ], "products": [ "species_2485002", "species_10697701" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10697598": { "compartment": "compartment_70101", "id": "reaction_10697598", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697587" ], "products": [ "species_10697595" ], "modifiers": [ [ "species_10697587", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10670675": { "compartment": "compartment_7660", "id": "reaction_10670675", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10670646" ], "products": [ "species_113550", "species_10670641" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10725467": { "compartment": "compartment_70101", "id": "reaction_10725467", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725465" ], "products": [ "species_10670680" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10679227": { "compartment": "compartment_7660", "id": "reaction_10679227", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679204", "species_29358" ], "products": [ "species_113582", "species_10679224" ], "modifiers": [ [ "species_10679204", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10678793": { "compartment": "compartment_7660", "id": "reaction_10678793", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678789", "species_113518" ], "products": [ "species_113550", "species_10678791" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10697034": { "compartment": "compartment_20699", "id": "reaction_10697034", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697026", "species_113592" ], "products": [ "species_29370", "species_10697031" ], "modifiers": [ [ "species_10697026", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248" ] }, "reaction_10697509": { "compartment": "compartment_7660", "id": "reaction_10697509", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697504", "species_29358" ], "products": [ "species_113582", "species_10697507" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10721628": { "compartment": "compartment_70101", "id": "reaction_10721628", "reactome": "R-DDI-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674818", "species_10721624" ], "products": [ "species_10721626" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10718372": { "compartment": "compartment_7660", "id": "reaction_10718372", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690363", "species_77087" ], "products": [ "species_10718364", "species_77502" ], "modifiers": [ [ "species_10718369", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0288271" ] }, "reaction_10690397": { "compartment": "compartment_7660", "id": "reaction_10690397", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690390", "species_10669917" ], "products": [ "species_10679187", "species_10690394" ], "modifiers": [ [ "species_10690390", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q54FX2", "DDB_G0290551", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10676510": { "compartment": "compartment_7660", "id": "reaction_10676510", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670361" ], "products": [ "species_10669535", "species_113656" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10679215": { "compartment": "compartment_7660", "id": "reaction_10679215", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10669684" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10679212": { "compartment": "compartment_7660", "id": "reaction_10679212", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679208" ], "products": [ "species_113582", "species_10679210" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679193": { "compartment": "compartment_7660", "id": "reaction_10679193", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679191" ], "products": [ "species_10679187", "species_10670389", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P34112", "DDB_G0272813", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "B0G102", "DDB_G0271642", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678870": { "compartment": "compartment_13231", "id": "reaction_10678870", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678592" ], "products": [ "species_10678791" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690368": { "compartment": "compartment_7660", "id": "reaction_10690368", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690013" ], "products": [ "species_113550", "species_10689991" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678849": { "compartment": "compartment_7660", "id": "reaction_10678849", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10678789" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10697448": { "compartment": "compartment_984", "id": "reaction_10697448", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697444", "species_10692323" ], "products": [ "species_10697446" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q54LD6", "DDB_G0286691", "Q55E77", "DDB_G0270488" ] }, "reaction_10721829": { "compartment": "compartment_17957", "id": "reaction_10721829", "reactome": "R-DDI-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692649" ], "products": [ "species_10692647", "species_10692513" ], "modifiers": [], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0280773" ] }, "reaction_10721764": { "compartment": "compartment_17957", "id": "reaction_10721764", "reactome": "R-DDI-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695220" ], "products": [ "species_10695222" ], "modifiers": [], "additional_components": [ "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721774": { "compartment": "compartment_17957", "id": "reaction_10721774", "reactome": "R-DDI-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694722", "species_10694792", "species_10694768", "species_10694746", "species_10694814", "species_10694700" ], "products": [ "species_10694818" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694524": { "compartment": "compartment_17957", "id": "reaction_10694524", "reactome": "R-DDI-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692579", "species_10692513" ], "products": [ "species_10692581" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "DDB_G0280773", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721748": { "compartment": "compartment_17957", "id": "reaction_10721748", "reactome": "R-DDI-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694886", "species_10694840", "species_10694862" ], "products": [ "species_10694892" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721766": { "compartment": "compartment_17957", "id": "reaction_10721766", "reactome": "R-DDI-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695286" ], "products": [ "species_10695288" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721776": { "compartment": "compartment_17957", "id": "reaction_10721776", "reactome": "R-DDI-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695072", "species_10694652", "species_10695050" ], "products": [ "species_10695074" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721742": { "compartment": "compartment_17957", "id": "reaction_10721742", "reactome": "R-DDI-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694914", "species_10694936" ], "products": [ "species_10694938" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721738": { "compartment": "compartment_17957", "id": "reaction_10721738", "reactome": "R-DDI-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694606", "species_10694628" ], "products": [ "species_10694630" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721772": { "compartment": "compartment_17957", "id": "reaction_10721772", "reactome": "R-DDI-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694652" ], "products": [ "species_10694654" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697502": { "compartment": "compartment_984", "id": "reaction_10697502", "reactome": "R-DDI-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_10697498" ], "products": [ "species_10697500" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10721768": { "compartment": "compartment_17957", "id": "reaction_10721768", "reactome": "R-DDI-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695096" ], "products": [ "species_10695098" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721750": { "compartment": "compartment_17957", "id": "reaction_10721750", "reactome": "R-DDI-8944225", "name": "Association of procollagen type XVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695168" ], "products": [ "species_10695170" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721752": { "compartment": "compartment_17957", "id": "reaction_10721752", "reactome": "R-DDI-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695240" ], "products": [ "species_10695242" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700154": { "compartment": "compartment_984", "id": "reaction_10700154", "reactome": "R-DDI-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700150", "species_10697474" ], "products": [ "species_10700152" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10693910": { "compartment": "compartment_17957", "id": "reaction_10693910", "reactome": "R-DDI-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693906" ], "products": [ "species_10693908" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721746": { "compartment": "compartment_17957", "id": "reaction_10721746", "reactome": "R-DDI-8944220", "name": "Association of procollagen type XXIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695262" ], "products": [ "species_10695264" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694522": { "compartment": "compartment_984", "id": "reaction_10694522", "reactome": "R-DDI-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694218" ], "products": [ "species_10694510" ], "modifiers": [ [ "species_10694515", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0279795" ] }, "reaction_10696111": { "compartment": "compartment_17957", "id": "reaction_10696111", "reactome": "R-DDI-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696025" ], "products": [ "species_10696109" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721762": { "compartment": "compartment_17957", "id": "reaction_10721762", "reactome": "R-DDI-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695310" ], "products": [ "species_10695312" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700148": { "compartment": "compartment_984", "id": "reaction_10700148", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700144", "species_10692323" ], "products": [ "species_10700146" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10721760": { "compartment": "compartment_17957", "id": "reaction_10721760", "reactome": "R-DDI-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694676" ], "products": [ "species_10694678" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721770": { "compartment": "compartment_17957", "id": "reaction_10721770", "reactome": "R-DDI-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695026" ], "products": [ "species_10695028" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721740": { "compartment": "compartment_17957", "id": "reaction_10721740", "reactome": "R-DDI-8944216", "name": "Association of procollagen type XV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695120" ], "products": [ "species_10695122" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10692690": { "compartment": "compartment_17957", "id": "reaction_10692690", "reactome": "R-DDI-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10692581" ], "products": [ "species_159751", "species_1650769", "species_10692649" ], "modifiers": [ [ "species_10692687", "catalyst" ] ], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "CHEBI:29073", "Q553P3", "DDB_G0292888", "Q54N51", "DDB_G0292888", "species_71067", "Q54TF2", "DDB_G0292888", "Q54CK1", "DDB_G0292888" ] }, "reaction_10721744": { "compartment": "compartment_17957", "id": "reaction_10721744", "reactome": "R-DDI-8944219", "name": "Association of procollagen type XVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695144" ], "products": [ "species_10695146" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10724718": { "compartment": "compartment_876", "id": "reaction_10724718", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10675991": { "compartment": "compartment_7660", "id": "reaction_10675991", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675987", "species_10675982" ], "products": [ "species_10675989" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q54S00", "DDB_G0282747", "Q55AZ3", "DDB_G0271608" ] }, "reaction_10703141": { "compartment": "compartment_7660", "id": "reaction_10703141", "reactome": "R-DDI-5653766", "name": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703137", "species_10703104" ], "products": [ "species_10703139" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "O96612", "DDB_G0275021", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10675750": { "compartment": "compartment_70101", "id": "reaction_10675750", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10677294": { "compartment": "compartment_70616", "id": "reaction_10677294", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10677291", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10686888": { "compartment": "compartment_70101", "id": "reaction_10686888", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686865": { "compartment": "compartment_70101", "id": "reaction_10686865", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675741": { "compartment": "compartment_70101", "id": "reaction_10675741", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686918": { "compartment": "compartment_20699", "id": "reaction_10686918", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10686876": { "compartment": "compartment_70101", "id": "reaction_10686876", "reactome": "R-DDI-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10686873", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686884": { "compartment": "compartment_20699", "id": "reaction_10686884", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10686881", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10687053": { "compartment": "compartment_876", "id": "reaction_10687053", "reactome": "R-DDI-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10687050", "catalyst" ] ], "additional_components": [ "species_209937", "species_176667", "species_209937", "species_176667", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10686921": { "compartment": "compartment_20699", "id": "reaction_10686921", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10675743": { "compartment": "compartment_70101", "id": "reaction_10675743", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675748": { "compartment": "compartment_70101", "id": "reaction_10675748", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10682847": { "compartment": "compartment_876", "id": "reaction_10682847", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682581": { "compartment": "compartment_876", "id": "reaction_10682581", "reactome": "R-DDI-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10682578", "catalyst" ] ], "additional_components": [ "species_351993", "species_29500", "species_352030", "species_351993", "species_29500", "species_352030", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10682845": { "compartment": "compartment_876", "id": "reaction_10682845", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682842", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "DDB_G0279983" ] }, "reaction_10682821": { "compartment": "compartment_876", "id": "reaction_10682821", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682840": { "compartment": "compartment_876", "id": "reaction_10682840", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682837", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10722317": { "compartment": "compartment_7660", "id": "reaction_10722317", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690002" ], "products": [ "species_10722315" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722398": { "compartment": "compartment_7660", "id": "reaction_10722398", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722315", "species_10722394" ], "products": [ "species_10722396" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54JZ0", "DDB_G0287727", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722387": { "compartment": "compartment_7660", "id": "reaction_10722387", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690004" ], "products": [ "species_10722385" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722987": { "compartment": "compartment_7660", "id": "reaction_10722987", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10722313" ], "products": [ "species_113582", "species_10722985" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10688476": { "compartment": "compartment_7660", "id": "reaction_10688476", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688251", "species_10688256" ], "products": [ "species_10688474" ], "modifiers": [], "additional_components": [ "DDB_G0285989", "DDB_G0281085", "Q54UG9", "DDB_G0281085", "Q54MF7", "DDB_G0285989" ] }, "reaction_10709807": { "compartment": "compartment_7660", "id": "reaction_10709807", "reactome": "R-DDI-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704976", "species_29358" ], "products": [ "species_113582", "species_10709804", "species_10682355" ], "modifiers": [ [ "species_10704976", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703096": { "compartment": "compartment_7660", "id": "reaction_10703096", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703089" ], "products": [ "species_10703093" ], "modifiers": [ [ "species_10703089", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10709844": { "compartment": "compartment_7660", "id": "reaction_10709844", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709797", "species_10705273" ], "products": [ "species_10709799" ], "modifiers": [], "additional_components": [ "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10702975": { "compartment": "compartment_7660", "id": "reaction_10702975", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10702970" ], "products": [ "species_10702972", "species_113550" ], "modifiers": [ [ "species_10702970", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705284": { "compartment": "compartment_7660", "id": "reaction_10705284", "reactome": "R-DDI-5682967", "name": "WHSC1 binds DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700897", "species_10705275" ], "products": [ "species_10705282" ], "modifiers": [], "additional_components": [ "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676006": { "compartment": "compartment_7660", "id": "reaction_10676006", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675974", "species_10675996" ], "products": [ "species_10675968", "species_10675998" ], "modifiers": [], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "DDB_G0277701", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10703099": { "compartment": "compartment_7660", "id": "reaction_10703099", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10703074" ], "products": [ "species_10703028", "species_5651834" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10711334": { "compartment": "compartment_7660", "id": "reaction_10711334", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709581", "species_10711318" ], "products": [ "species_10698305", "species_10711329" ], "modifiers": [ [ "species_10711331", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q869L7", "DDB_G0279421", "Q54TK0", "DDB_G0281703", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54SX2", "DDB_G0282161", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710378": { "compartment": "compartment_7660", "id": "reaction_10710378", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710373", "species_113518" ], "products": [ "species_10675845", "species_10669917" ], "modifiers": [ [ "species_10710375", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0267682", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0274207" ] }, "reaction_10725845": { "compartment": "compartment_7660", "id": "reaction_10725845", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710820", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10710831" ], "modifiers": [ [ "species_10710820", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10674796": { "compartment": "compartment_7660", "id": "reaction_10674796", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674787", "species_10674792" ], "products": [ "species_10674794" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54BN2", "DDB_G0293546" ] }, "reaction_10710837": { "compartment": "compartment_7660", "id": "reaction_10710837", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710833", "species_10675852" ], "products": [ "species_10710835" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709584": { "compartment": "compartment_7660", "id": "reaction_10709584", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709577", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10709581" ], "modifiers": [ [ "species_10709577", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10710592": { "compartment": "compartment_7660", "id": "reaction_10710592", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710586", "species_10703028" ], "products": [ "species_10710588" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10674087": { "compartment": "compartment_7660", "id": "reaction_10674087", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674080" ], "products": [ "species_10674084" ], "modifiers": [ [ "species_10674080", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10705287": { "compartment": "compartment_7660", "id": "reaction_10705287", "reactome": "R-DDI-5682983", "name": "ATM phosphorylates WHSC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705282" ], "products": [ "species_113582", "species_10705277" ], "modifiers": [ [ "species_10705282", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709814": { "compartment": "compartment_7660", "id": "reaction_10709814", "reactome": "R-DDI-5693566", "name": "TP53BP1 associates with H4K20Me2 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705317", "species_10698412" ], "products": [ "species_10705325" ], "modifiers": [], "additional_components": [ "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0286539", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676004": { "compartment": "compartment_7660", "id": "reaction_10676004", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675996", "species_10675953" ], "products": [ "species_10675947", "species_10675998" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10705333": { "compartment": "compartment_7660", "id": "reaction_10705333", "reactome": "R-DDI-5683425", "name": "ATM phosphorylates TP53BP1 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705325", "species_29358" ], "products": [ "species_113582", "species_10705323" ], "modifiers": [ [ "species_10705325", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10710857": { "compartment": "compartment_7660", "id": "reaction_10710857", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710853", "species_10710851", "species_10670546", "species_10710839" ], "products": [ "species_10710855" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54RD4", "DDB_G0283189", "Q54KS3", "DDB_G0287149", "Q54Y85", "DDB_G0278367", "Q54TN8", "DDB_G0281641", "Q7KWN0", "DDB_G0272740", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q75JQ9", "DDB_G0272222", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q54N41", "DDB_G0285521", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54BN3", "DDB_G0293702", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q54Y85", "DDB_G0278367", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54RD4", "DDB_G0283189", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54ST4", "DDB_G0282235", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10709802": { "compartment": "compartment_7660", "id": "reaction_10709802", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709799" ], "products": [ "species_113582", "species_10705275" ], "modifiers": [ [ "species_10709799", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10676017": { "compartment": "compartment_7660", "id": "reaction_10676017", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010", "species_10674064" ], "products": [ "species_10676015" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10703020": { "compartment": "compartment_7660", "id": "reaction_10703020", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676029", "species_10674064" ], "products": [ "species_10676031" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10676000": { "compartment": "compartment_7660", "id": "reaction_10676000", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675902", "species_10675996" ], "products": [ "species_10675896", "species_10675998" ], "modifiers": [], "additional_components": [ "P53766", "DDB_G0277877", "DDB_G0277701", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10703083": { "compartment": "compartment_7660", "id": "reaction_10703083", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703076" ], "products": [ "species_10703074", "species_10703081" ], "modifiers": [], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10709648": { "compartment": "compartment_7660", "id": "reaction_10709648", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10709644", "species_10709590" ], "products": [ "species_10709646", "species_10709642" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10710842": { "compartment": "compartment_7660", "id": "reaction_10710842", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710835" ], "products": [ "species_10710839" ], "modifiers": [ [ "species_10710835", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10676020": { "compartment": "compartment_7660", "id": "reaction_10676020", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676015" ], "products": [ "species_10675996", "species_10674091", "species_30977" ], "modifiers": [ [ "species_10676015", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10705280": { "compartment": "compartment_7660", "id": "reaction_10705280", "reactome": "R-DDI-5682965", "name": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705277", "species_77087" ], "products": [ "species_10705231", "species_77502" ], "modifiers": [ [ "species_10705277", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10675854": { "compartment": "compartment_7660", "id": "reaction_10675854", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675845", "species_10675850" ], "products": [ "species_10675852" ], "modifiers": [], "additional_components": [ "DDB_G0267682", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10703037": { "compartment": "compartment_7660", "id": "reaction_10703037", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676035", "species_10703028", "species_10670606" ], "products": [ "species_10703030", "species_10675996" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0284987", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "DDB_G0277701", "DDB_G0277943" ] }, "reaction_10725405": { "compartment": "compartment_70101", "id": "reaction_10725405", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725401" ], "products": [ "species_10725403" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10709812": { "compartment": "compartment_7660", "id": "reaction_10709812", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709809" ], "products": [ "species_113582", "species_10705388" ], "modifiers": [ [ "species_10709809", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10703045": { "compartment": "compartment_7660", "id": "reaction_10703045", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10703030" ], "products": [ "species_10703042", "species_113541" ], "modifiers": [ [ "species_10703030", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10676013": { "compartment": "compartment_7660", "id": "reaction_10676013", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675998" ], "products": [ "species_10676010" ], "modifiers": [ [ "species_10675998", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10702985": { "compartment": "compartment_7660", "id": "reaction_10702985", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702977" ], "products": [ "species_10702982" ], "modifiers": [ [ "species_10702977", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705330": { "compartment": "compartment_7660", "id": "reaction_10705330", "reactome": "R-DDI-5683405", "name": "PPP5C dephosphorylates TP53BP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705323" ], "products": [ "species_10705325", "species_113550" ], "modifiers": [ [ "species_10705327", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0283157" ] }, "reaction_10702980": { "compartment": "compartment_7660", "id": "reaction_10702980", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702972", "species_30555" ], "products": [ "species_113541", "species_10702977" ], "modifiers": [ [ "species_10702972", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10703079": { "compartment": "compartment_7660", "id": "reaction_10703079", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10703042" ], "products": [ "species_10703076", "species_427497" ], "modifiers": [ [ "species_10703042", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10710590": { "compartment": "compartment_7660", "id": "reaction_10710590", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710588", "species_427523" ], "products": [ "species_427497", "species_10709573" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10705265": { "compartment": "compartment_7660", "id": "reaction_10705265", "reactome": "R-DDI-5682629", "name": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705253", "species_10705259" ], "products": [ "species_10705263" ], "modifiers": [], "additional_components": [ "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54D06", "DDB_G0292596", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709592": { "compartment": "compartment_7660", "id": "reaction_10709592", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709562", "species_10700619", "species_10700558" ], "products": [ "species_10709590" ], "modifiers": [], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54WU9", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10709847": { "compartment": "compartment_7660", "id": "reaction_10709847", "reactome": "R-DDI-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709804", "species_29358" ], "products": [ "species_113582", "species_10705206" ], "modifiers": [ [ "species_10709804", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703207": { "compartment": "compartment_7660", "id": "reaction_10703207", "reactome": "R-DDI-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703190" ], "products": [ "species_10703202", "species_10703204", "species_10703188" ], "modifiers": [ [ "species_10703190", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "DDB_G0290453", "DDB_G0290453", "DDB_G0277533", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453" ] }, "reaction_10676002": { "compartment": "compartment_7660", "id": "reaction_10676002", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675918", "species_10675996" ], "products": [ "species_10675889", "species_10675998" ], "modifiers": [], "additional_components": [ "Q86K43", "DDB_G0277247", "DDB_G0277701", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10703022": { "compartment": "compartment_7660", "id": "reaction_10703022", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010" ], "products": [ "species_10676029" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10676038": { "compartment": "compartment_7660", "id": "reaction_10676038", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676031", "species_30555" ], "products": [ "species_10676035", "species_113541" ], "modifiers": [ [ "species_10676031", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10709851": { "compartment": "compartment_7660", "id": "reaction_10709851", "reactome": "R-DDI-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705374", "species_10705206" ], "products": [ "species_10709809" ], "modifiers": [], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10674096": { "compartment": "compartment_7660", "id": "reaction_10674096", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10674093" ], "products": [ "species_113541", "species_10674080" ], "modifiers": [ [ "species_10674093", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710877": { "compartment": "compartment_7660", "id": "reaction_10710877", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709646", "species_10669917" ], "products": [ "species_10710586" ], "modifiers": [ [ "species_10709646", "catalyst" ] ], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357" ] }, "reaction_10704979": { "compartment": "compartment_7660", "id": "reaction_10704979", "reactome": "R-DDI-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704974", "species_113560" ], "products": [ "species_2485002", "species_10704976" ], "modifiers": [ [ "species_10704974", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703091": { "compartment": "compartment_7660", "id": "reaction_10703091", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703087", "species_10670614" ], "products": [ "species_10703089" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10710823": { "compartment": "compartment_7660", "id": "reaction_10710823", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10710797" ], "products": [ "species_113582", "species_10710820", "species_113550" ], "modifiers": [ [ "species_10710797", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709588": { "compartment": "compartment_7660", "id": "reaction_10709588", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10709573" ], "products": [ "species_10709586" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10676022": { "compartment": "compartment_7660", "id": "reaction_10676022", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674078", "species_10674091" ], "products": [ "species_10674093" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710849": { "compartment": "compartment_7660", "id": "reaction_10710849", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10710844" ], "products": [ "species_10710846", "species_113541" ], "modifiers": [ [ "species_10710844", "catalyst" ] ], "additional_components": [ "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10682781": { "compartment": "compartment_70101", "id": "reaction_10682781", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_5279533" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10681988": { "compartment": "compartment_70101", "id": "reaction_10681988", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10681985" ], "products": [ "species_10681963" ], "modifiers": [ [ "species_10681985", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "species_113552", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043" ] }, "reaction_10687261": { "compartment": "compartment_5460", "id": "reaction_10687261", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10687258", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q55FI1", "DDB_G0268104" ] }, "reaction_10724738": { "compartment": "compartment_876", "id": "reaction_10724738", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10682758" ], "products": [ "species_10682761" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10724723": { "compartment": "compartment_70101", "id": "reaction_10724723", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10724720", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10725941": { "compartment": "compartment_70101", "id": "reaction_10725941", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10725938", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10684216": { "compartment": "compartment_876", "id": "reaction_10684216", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684051" ], "products": [ "species_10684213" ], "modifiers": [ [ "species_10684051", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438" ] }, "reaction_10712040": { "compartment": "compartment_876", "id": "reaction_10712040", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10712037", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10683869": { "compartment": "compartment_876", "id": "reaction_10683869", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10683865" ], "products": [ "species_10683867" ], "modifiers": [], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10725991": { "compartment": "compartment_70101", "id": "reaction_10725991", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10722710": { "compartment": "compartment_876", "id": "reaction_10722710", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722706", "species_10683865" ], "products": [ "species_10722708" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684207": { "compartment": "compartment_70101", "id": "reaction_10684207", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10684204", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10683912": { "compartment": "compartment_70101", "id": "reaction_10683912", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683909", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P36408", "DDB_G0277143", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10724275": { "compartment": "compartment_70101", "id": "reaction_10724275", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825", "species_10683777" ], "products": [ "species_10724273" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10722760": { "compartment": "compartment_876", "id": "reaction_10722760", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722758" ], "products": [ "species_10722706", "species_10686923" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10722770": { "compartment": "compartment_876", "id": "reaction_10722770", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722708" ], "products": [ "species_10722758", "species_29372" ], "modifiers": [ [ "species_10722708", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10698635": { "compartment": "compartment_70101", "id": "reaction_10698635", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10698631" ], "products": [ "species_10698633" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "species_874088", "Q54BN2", "DDB_G0293546" ] }, "reaction_10723428": { "compartment": "compartment_70101", "id": "reaction_10723428", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698604", "species_8982080" ], "products": [ "species_10723426" ], "modifiers": [], "additional_components": [ "DDB_G0287361", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q54KG1", "DDB_G0287361" ] }, "reaction_10682899": { "compartment": "compartment_70101", "id": "reaction_10682899", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682888", "species_10682859" ], "products": [ "species_10682853", "species_10682894", "species_10682859" ], "modifiers": [ [ "species_10682896", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q55GN5", "DDB_G0267590", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10702014": { "compartment": "compartment_263163", "id": "reaction_10702014", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10702010" ], "products": [ "species_10702012" ], "modifiers": [], "additional_components": [ "B0G185", "DDB_G0295711", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031", "B0G185", "DDB_G0295711", "species_1806205", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031" ] }, "reaction_10682916": { "compartment": "compartment_876", "id": "reaction_10682916", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682905", "species_10682853", "species_10682859" ], "products": [ "species_10682911", "species_10682853", "species_10682859" ], "modifiers": [ [ "species_10682913", "catalyst" ] ], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10682453": { "compartment": "compartment_70101", "id": "reaction_10682453", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682429", "species_29438" ], "products": [ "species_10682433", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "species_29420", "O00909", "DDB_G0289173", "O00909", "DDB_G0289173", "species_29438", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10682882": { "compartment": "compartment_70101", "id": "reaction_10682882", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682871", "species_10682859" ], "products": [ "species_10682853", "species_10682859", "species_10682877" ], "modifiers": [ [ "species_10682879", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951" ] }, "reaction_10701766": { "compartment": "compartment_171907", "id": "reaction_10701766", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701749" ], "products": [ "species_10701763" ], "modifiers": [ [ "species_10701749", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10679542": { "compartment": "compartment_984", "id": "reaction_10679542", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679281": { "compartment": "compartment_984", "id": "reaction_10679281", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10722325": { "compartment": "compartment_7660", "id": "reaction_10722325", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953383", "species_8953399" ], "modifiers": [ [ "species_10722322", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10679278": { "compartment": "compartment_984", "id": "reaction_10679278", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679538": { "compartment": "compartment_984", "id": "reaction_10679538", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679540": { "compartment": "compartment_984", "id": "reaction_10679540", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10703366": { "compartment": "compartment_984", "id": "reaction_10703366", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679288": { "compartment": "compartment_984", "id": "reaction_10679288", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10695627": { "compartment": "compartment_876", "id": "reaction_10695627", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10695624", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "Q54WR4", "DDB_G0279483" ] }, "reaction_10695602": { "compartment": "compartment_876", "id": "reaction_10695602", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10695599", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10718995": { "compartment": "compartment_876", "id": "reaction_10718995", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692772", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10718847": { "compartment": "compartment_876", "id": "reaction_10718847", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718843", "species_10718837" ], "products": [ "species_10718845" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10720418": { "compartment": "compartment_876", "id": "reaction_10720418", "reactome": "R-DDI-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_179856" ], "products": [ "species_10718325" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718711": { "compartment": "compartment_70101", "id": "reaction_10718711", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718707", "species_10718699" ], "products": [ "species_10718709" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10718568": { "compartment": "compartment_70101", "id": "reaction_10718568", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718564", "species_10718544", "species_10718532" ], "products": [ "species_10718566" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10718522": { "compartment": "compartment_876", "id": "reaction_10718522", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718315", "species_10681832", "species_10718335", "species_10718319", "species_10718325", "species_10718317" ], "products": [ "species_10718337" ], "modifiers": [], "additional_components": [ "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718577": { "compartment": "compartment_70101", "id": "reaction_10718577", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709499", "species_10718570" ], "products": [ "species_10718532" ], "modifiers": [], "additional_components": [ "DDB_G0278711", "DDB_G0277139", "DDB_G0277139" ] }, "reaction_10718347": { "compartment": "compartment_876", "id": "reaction_10718347", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_10718337", "species_10718343", "species_10718275" ], "products": [ "species_10718345" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10719091": { "compartment": "compartment_24339", "id": "reaction_10719091", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719089", "species_10719055" ], "products": [ "species_10719087" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102", "species_113592", "P36415", "DDB_G0269144", "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "P36415", "DDB_G0269144", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102" ] }, "reaction_10718357": { "compartment": "compartment_876", "id": "reaction_10718357", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718345", "species_113592" ], "products": [ "species_29370", "species_10718354" ], "modifiers": [ [ "species_10718345", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718998": { "compartment": "compartment_876", "id": "reaction_10718998", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10718914", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q54S78", "DDB_G0282625", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "P54673", "DDB_G0278727", "Q75JD4", "DDB_G0274695", "P54675", "DDB_G0275011", "Q54U74", "DDB_G0281235", "Q9BKJ9", "DDB_G0287035", "Q54VV7", "DDB_G0280111", "Q54GB3", "DDB_G0290363", "P25870", "DDB_G0277221", "Q54Y50", "DDB_G0278685", "Q54X82", "DDB_G0279141", "Q6TMJ9", "DDB_G0280061", "Q54UC8", "DDB_G0281155", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718721": { "compartment": "compartment_876", "id": "reaction_10718721", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10718715" ], "products": [ "species_10718717" ], "modifiers": [ [ "species_10718719", "inhibitor" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q9BKJ9", "DDB_G0287035", "Q54UC8", "DDB_G0281155", "Q9BKJ9", "DDB_G0287035", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54UC8", "DDB_G0281155", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10718575": { "compartment": "compartment_70101", "id": "reaction_10718575", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718566" ], "products": [ "species_10718564", "species_10718544", "species_10709499", "species_10718570" ], "modifiers": [ [ "species_10718566", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0278711", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10725842": { "compartment": "compartment_70101", "id": "reaction_10725842", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_9648300" ], "products": [ "species_10718719" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10698195": { "compartment": "compartment_70101", "id": "reaction_10698195", "reactome": "R-DDI-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698192", "catalyst" ] ], "additional_components": [ "DDB_G0290313" ] }, "reaction_10698213": { "compartment": "compartment_70101", "id": "reaction_10698213", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_29372" ], "products": [ "species_2892454", "species_113551" ], "modifiers": [ [ "species_10698210", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10698117": { "compartment": "compartment_70101", "id": "reaction_10698117", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698114", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698178": { "compartment": "compartment_70101", "id": "reaction_10698178", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698175", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10698125": { "compartment": "compartment_70101", "id": "reaction_10698125", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10698122", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10698190": { "compartment": "compartment_70101", "id": "reaction_10698190", "reactome": "R-DDI-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698187", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54G87", "DDB_G0290313" ] }, "reaction_10698982": { "compartment": "compartment_70101", "id": "reaction_10698982", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10698913", "catalyst" ], [ "species_10698980", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10725463": { "compartment": "compartment_70101", "id": "reaction_10725463", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698070", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698204": { "compartment": "compartment_70101", "id": "reaction_10698204", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10698201", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10685792": { "compartment": "compartment_876", "id": "reaction_10685792", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685018": { "compartment": "compartment_876", "id": "reaction_10685018", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10685015", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10685539": { "compartment": "compartment_876", "id": "reaction_10685539", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10685536", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10685554": { "compartment": "compartment_876", "id": "reaction_10685554", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685476": { "compartment": "compartment_876", "id": "reaction_10685476", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10685473", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10685794": { "compartment": "compartment_876", "id": "reaction_10685794", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10722613": { "compartment": "compartment_70101", "id": "reaction_10722613", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10722610", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685568": { "compartment": "compartment_876", "id": "reaction_10685568", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10685434": { "compartment": "compartment_876", "id": "reaction_10685434", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10685431", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10685563": { "compartment": "compartment_876", "id": "reaction_10685563", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685429": { "compartment": "compartment_172574", "id": "reaction_10685429", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10685426", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_29418", "species_29426", "species_71067", "species_29418", "DDB_G0276973" ] }, "reaction_10685421": { "compartment": "compartment_876", "id": "reaction_10685421", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_446589", "species_351626" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10685418", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10687849": { "compartment": "compartment_70101", "id": "reaction_10687849", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"DDB_G0277907", "Q54MZ5", "DDB_G0285597", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "Q55E21", "DDB_G0270866", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q54G90", "DDB_G0290307", "Q55BS9", "DDB_G0270380", "species_29420", "Q55D61", "DDB_G0269192", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X51", "DDB_G0279207", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54NG2", "DDB_G0285277", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q9BMX0", "DDB_G0288613", "Q55A46", "DDB_G0272108", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54ME8", "DDB_G0286007", "Q54J50", "DDB_G0288295", "Q7YZN9", "DDB_G0277919", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q75JP6", "DDB_G0272470", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q54KR9", "DDB_G0287197", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "Q54I89", "DDB_G0288923", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q55BN7", "DDB_G0270424", "Q54DH9", "DDB_G0292240", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "Q55D17", "DDB_G0269814", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q1ZXC2", "DDB_G0290745", "P22683", "DDB_G0283393", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984" ] }, "reaction_10675713": { "compartment": "compartment_7660", "id": "reaction_10675713", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675707", "species_10675016" ], "products": [ "species_10675711" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405" ] }, "reaction_10675717": { "compartment": "compartment_7660", "id": "reaction_10675717", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675711" ], "products": [ "species_10675715" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10675709": { "compartment": "compartment_7660", "id": "reaction_10675709", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83747", "species_10675045" ], "products": [ "species_10675707" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127" ] }, "reaction_10679857": { "compartment": "compartment_13231", "id": "reaction_10679857", "reactome": "R-DDI-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677717" ], "products": [ "species_10679855" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10681841": { "compartment": "compartment_70101", "id": "reaction_10681841", "reactome": "R-DDI-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [ [ "species_10681384", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10681837": { "compartment": "compartment_70101", "id": "reaction_10681837", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681382" ], "products": [ "species_10681384", "species_29420" ], "modifiers": [ [ "species_10681834", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_111349", "P34144", "DDB_G0277869", "species_29438", "Q54F64", "DDB_G0291085", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q86HN1", "DDB_G0293396", "Q8IS12", "DDB_G0275703", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "Q54DW4", "DDB_G0291978", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q54B37", "DDB_G0293978", "Q8IS16", "DDB_G0276963", "Q55G61", "DDB_G0268354", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q1ZX99", "DDB_G0293928", "Q55FD8", "DDB_G0268578", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10704220": { "compartment": "compartment_876", "id": "reaction_10704220", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704091", "species_10678454" ], "products": [ "species_10704218" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704343": { "compartment": "compartment_876", "id": "reaction_10704343", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704339", "species_10704334" ], "products": [ "species_10704341" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q54QK0", "DDB_G0283803", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10704230": { "compartment": "compartment_876", "id": "reaction_10704230", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10704218" ], "products": [ "species_10704227" ], "modifiers": [ [ "species_10704218", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703817": { "compartment": "compartment_876", "id": "reaction_10703817", "reactome": "R-DDI-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703808", "species_10678454" ], "products": [ "species_10703810" ], "modifiers": [ [ "species_10703815", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0290123" ] }, "reaction_10725190": { "compartment": "compartment_70101", "id": "reaction_10725190", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725136", "species_2530486" ], "products": [ "species_10725178", "species_111294" ], "modifiers": [ [ "species_10725185", "catalyst" ], [ "species_10725188", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10704105": { "compartment": "compartment_876", "id": "reaction_10704105", "reactome": "R-DDI-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703810", "species_10704084" ], "products": [ "species_10704086" ], "modifiers": [ [ "species_10704103", "catalyst" ], [ "species_10704093", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10725346": { "compartment": "compartment_876", "id": "reaction_10725346", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678450", "species_10676232" ], "products": [ "species_10725344" ], "modifiers": [ [ "species_10725342", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725393": { "compartment": "compartment_876", "id": "reaction_10725393", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725344" ], "products": [ "species_10725391" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "species_74016", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "Q7Z2B8", "DDB_G0277917", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703913": { "compartment": "compartment_70101", "id": "reaction_10703913", "reactome": "R-DDI-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703911" ], "products": [ "species_10674713", "species_10703909" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703705": { "compartment": "compartment_70101", "id": "reaction_10703705", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_113592" ], "products": [ "species_29370", "species_10703702" ], "modifiers": [ [ "species_10703686", "catalyst" ] ], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10704378": { "compartment": "compartment_876", "id": "reaction_10704378", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10704334" ], "products": [ "species_10704355", "species_29372" ], "modifiers": [ [ "species_10704375", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0283157" ] }, "reaction_10725283": { "compartment": "compartment_70101", "id": "reaction_10725283", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725185", "species_9653479" ], "products": [ "species_10725188" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10703885": { "compartment": "compartment_70101", "id": "reaction_10703885", "reactome": "R-DDI-5672957", "name": "PP2A dephosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703868", "species_29356" ], "products": [ "species_10703882", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10703358": { "compartment": "compartment_70101", "id": "reaction_10703358", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10703324" ], "products": [ "species_10703353" ], "modifiers": [ [ "species_10703355", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10725301": { "compartment": "compartment_876", "id": "reaction_10725301", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725255", "species_29356" ], "products": [ "species_10678450", "species_8848337" ], "modifiers": [ [ "species_10725294", "catalyst" ], [ "species_10725296", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10725093": { "compartment": "compartment_12045", "id": "reaction_10725093", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725069", "species_71284" ], "products": [ "species_10725089", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ], [ "species_10725091", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "species_29426", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "pubchem.compound:6918831" ] }, "reaction_10725304": { "compartment": "compartment_12045", "id": "reaction_10725304", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089" ], "products": [ "species_10678450" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703887": { "compartment": "compartment_70101", "id": "reaction_10703887", "reactome": "R-DDI-5672958", "name": "YWHAB dimer dissociates from KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703882" ], "products": [ "species_10703880", "species_10674713" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138" ] }, "reaction_10725460": { "compartment": "compartment_876", "id": "reaction_10725460", "reactome": "R-DDI-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10725457", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "O15757", "DDB_G0275619", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54HA8", "DDB_G0289585", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704222": { "compartment": "compartment_70101", "id": "reaction_10704222", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_10704091" ], "products": [ "species_10704093" ], "modifiers": [], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "DDB_G0270200", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703915": { "compartment": "compartment_70101", "id": "reaction_10703915", "reactome": "R-DDI-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10704272": { "compartment": "compartment_20699", "id": "reaction_10704272", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10704268" ], "products": [ "species_10704270" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54B86", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54HC6", "DDB_G0289555", "Q54B86", "DDB_G0293838", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54XX5", "DDB_G0278535", "Q54CB4", "DDB_G0293838" ] }, "reaction_10725637": { "compartment": "compartment_876", "id": "reaction_10725637", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725633", "species_10725631" ], "products": [ "species_10725635" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54VD5", "DDB_G0280437", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "species_29438", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725306": { "compartment": "compartment_876", "id": "reaction_10725306", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678452", "species_29420" ], "products": [ "species_10679153" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703364": { "compartment": "compartment_876", "id": "reaction_10703364", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703308", "species_10703322" ], "products": [ "species_10703324" ], "modifiers": [], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10725369": { "compartment": "compartment_17906", "id": "reaction_10725369", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725342" ], "products": [ "species_10725367" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725313": { "compartment": "compartment_876", "id": "reaction_10725313", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10704086" ], "products": [ "species_10704209" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10725257": { "compartment": "compartment_876", "id": "reaction_10725257", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725253" ], "products": [ "species_10725255" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725298": { "compartment": "compartment_876", "id": "reaction_10725298", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10725294" ], "products": [ "species_10725296" ], "modifiers": [], "additional_components": [ "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10704082": { "compartment": "compartment_876", "id": "reaction_10704082", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10704079", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725281": { "compartment": "compartment_20699", "id": "reaction_10725281", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089", "species_200993" ], "products": [ "species_76194", "species_10725253" ], "modifiers": [ [ "species_10725278", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54PF0", "DDB_G0284603", "Q557H5", "DDB_G0284603", "Q550I3", "DDB_G0277093", "Q550R7", "DDB_G0284603" ] }, "reaction_10703362": { "compartment": "compartment_876", "id": "reaction_10703362", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703326", "species_10678454" ], "products": [ "species_10703328" ], "modifiers": [], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10704369": { "compartment": "compartment_876", "id": "reaction_10704369", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704355", "species_29356" ], "products": [ "species_10704367", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ], [ "species_10704306", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703360": { "compartment": "compartment_70101", "id": "reaction_10703360", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703353" ], "products": [ "species_10703308" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703870": { "compartment": "compartment_70101", "id": "reaction_10703870", "reactome": "R-DDI-5672954", "name": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674713", "species_10703702" ], "products": [ "species_10703868" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703866": { "compartment": "compartment_70101", "id": "reaction_10703866", "reactome": "R-DDI-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10674713" ], "products": [ "species_10703864" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703331": { "compartment": "compartment_876", "id": "reaction_10703331", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703328" ], "products": [ "species_10703326", "species_10679153" ], "modifiers": [ [ "species_10703328", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10725311": { "compartment": "compartment_876", "id": "reaction_10725311", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678454" ], "products": [ "species_10679153" ], "modifiers": [ [ "species_10678454", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725308": { "compartment": "compartment_876", "id": "reaction_10725308", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10676462": { "compartment": "compartment_7660", "id": "reaction_10676462", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676308", "species_10676297" ], "products": [ "species_10676310" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10676470": { "compartment": "compartment_7660", "id": "reaction_10676470", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676446" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676448": { "compartment": "compartment_7660", "id": "reaction_10676448", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676446" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676452": { "compartment": "compartment_7660", "id": "reaction_10676452", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676450" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674872": { "compartment": "compartment_7660", "id": "reaction_10674872", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674862" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674197": { "compartment": "compartment_7660", "id": "reaction_10674197", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674195" ], "products": [ "species_10674193", "species_109877", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10676460": { "compartment": "compartment_7660", "id": "reaction_10676460", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676365", "species_10676370" ], "products": [ "species_10676372" ], "modifiers": [], "additional_components": [ "DDB_G0290331", "DDB_G0282677", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331" ] }, "reaction_10676464": { "compartment": "compartment_7660", "id": "reaction_10676464", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676331", "species_10675598" ], "products": [ "species_10676333" ], "modifiers": [], "additional_components": [ "DDB_G0285293", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10674956": { "compartment": "compartment_7660", "id": "reaction_10674956", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674954" ], "products": [ "species_10674193", "species_10673970", "species_75897", "species_10672167" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676468": { "compartment": "compartment_7660", "id": "reaction_10676468", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676380" ], "products": [ "species_10676380" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676474": { "compartment": "compartment_7660", "id": "reaction_10676474", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676476": { "compartment": "compartment_7660", "id": "reaction_10676476", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674860": { "compartment": "compartment_7660", "id": "reaction_10674860", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674858" ], "products": [ "species_10674193", "species_110068", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10724807": { "compartment": "compartment_17938", "id": "reaction_10724807", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724887", "species_10677461" ], "products": [ "species_10724894" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "Q54D08", "DDB_G0292592", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091" ] }, "reaction_10724881": { "compartment": "compartment_17938", "id": "reaction_10724881", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_10724875" ], "products": [ "species_10724877", "species_10724879" ], "modifiers": [], "additional_components": [ "Q54UN5", "DDB_G0280947", "Q54WU6", "DDB_G0279427", "Q54JS5", "DDB_G0287817", "Q55BD9", "DDB_G0271288", "Q551B5", "DDB_G0276673", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54XA2", "DDB_G0279099", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54UN5", "DDB_G0280947", "Q54JS5", "DDB_G0287817", "Q551B5", "DDB_G0276673", "Q55BD9", "DDB_G0271288", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q86K39", "DDB_G0277257", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54XA2", "DDB_G0279099", "Q54WU6", "DDB_G0279427", "species_29588" ] }, "reaction_10724892": { "compartment": "compartment_17938", "id": "reaction_10724892", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10724885" ], "products": [ "species_10724889", "species_29420" ], "modifiers": [ [ "species_10724885", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701" ] }, "reaction_10724992": { "compartment": "compartment_17938", "id": "reaction_10724992", "reactome": "R-DDI-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724800" ], "products": [ "species_10724804", "species_29372" ], "modifiers": [ [ "species_10724800", "catalyst" ], [ "species_10724990", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54HT9", "DDB_G0289243", "Q54UF2", "DDB_G0281111" ] }, "reaction_10726077": { "compartment": "compartment_12045", "id": "reaction_10726077", "reactome": "R-DDI-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10683360" ], "products": [ "species_10683368" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10726080": { "compartment": "compartment_12045", "id": "reaction_10726080", "reactome": "R-DDI-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10683368", "catalyst" ] ], "additional_components": [ "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10702919": { "compartment": "compartment_7660", "id": "reaction_10702919", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702917" ], "products": [ "species_10669917", "species_10702915" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10702926": { "compartment": "compartment_7660", "id": "reaction_10702926", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702923", "species_10669917" ], "products": [ "species_10702917" ], "modifiers": [ [ "species_10702923", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428" ] }, "reaction_10687980": { "compartment": "compartment_70101", "id": "reaction_10687980", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687942", "species_10687976" ], "products": [ "species_10687978" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q86L44", "DDB_G0294407", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10686695": { "compartment": "compartment_876", "id": "reaction_10686695", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10686697": { "compartment": "compartment_876", "id": "reaction_10686697", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10680301": { "compartment": "compartment_70101", "id": "reaction_10680301", "reactome": "R-DDI-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_10680289", "species_29372" ], "modifiers": [ [ "species_10680298", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54AX5", "DDB_G0294094", "species_29418" ] }, "reaction_10680303": { "compartment": "compartment_876", "id": "reaction_10680303", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680166", "species_10680149" ], "products": [ "species_10680168" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10718529": { "compartment": "compartment_984", "id": "reaction_10718529", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718524", "species_109276" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10718524", "catalyst" ] ], "additional_components": [ "Q54XV8", "DDB_G0278563", "species_6789198", "species_1236719", "CHEBI:21615", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10715120": { "compartment": "compartment_984", "id": "reaction_10715120", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677636", "species_6803081" ], "products": [ "species_10715118" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_6803081" ] }, "reaction_10718526": { "compartment": "compartment_984", "id": "reaction_10718526", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712951", "species_6789198" ], "products": [ "species_10718524" ], "modifiers": [], "additional_components": [ "DDB_G0278563", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10700306": { "compartment": "compartment_7660", "id": "reaction_10700306", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700290" ], "products": [ "species_10700304" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10700369": { "compartment": "compartment_70101", "id": "reaction_10700369", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700363" ], "products": [ "species_10700367" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10700238": { "compartment": "compartment_70101", "id": "reaction_10700238", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10700235", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "B0G0Y8", "DDB_G0268634", "species_29438" ] }, "reaction_10702112": { "compartment": "compartment_70101", "id": "reaction_10702112", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10702109", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10684759": { "compartment": "compartment_876", "id": "reaction_10684759", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10684756", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10684628": { "compartment": "compartment_20699", "id": "reaction_10684628", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10684625", "catalyst" ] ], "additional_components": [ "DDB_G0281877" ] }, "reaction_10722684": { "compartment": "compartment_70101", "id": "reaction_10722684", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722681", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720523": { "compartment": "compartment_70101", "id": "reaction_10720523", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10720520", "catalyst" ] ], "additional_components": [ "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10720514": { "compartment": "compartment_70101", "id": "reaction_10720514", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10720511", "catalyst" ] ], "additional_components": [ "DDB_G0276663" ] }, "reaction_10684806": { "compartment": "compartment_201753", "id": "reaction_10684806", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10684803", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10684991": { "compartment": "compartment_876", "id": "reaction_10684991", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10684988", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684892": { "compartment": "compartment_876", "id": "reaction_10684892", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10684889", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10722668": { "compartment": "compartment_70101", "id": "reaction_10722668", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722665", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684623": { "compartment": "compartment_876", "id": "reaction_10684623", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10684620", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10685930": { "compartment": "compartment_70101", "id": "reaction_10685930", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10722673": { "compartment": "compartment_70101", "id": "reaction_10722673", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722670", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10702091": { "compartment": "compartment_70101", "id": "reaction_10702091", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685921", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720498": { "compartment": "compartment_70101", "id": "reaction_10720498", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10720493", "catalyst" ] ], "additional_components": [ "DDB_G0276933" ] }, "reaction_10685010": { "compartment": "compartment_876", "id": "reaction_10685010", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685007", "catalyst" ] ], "additional_components": [ "Q54UC8", "DDB_G0281155", "Q54M69", "DDB_G0286151" ] }, "reaction_10722686": { "compartment": "compartment_70101", "id": "reaction_10722686", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720653": { "compartment": "compartment_70101", "id": "reaction_10720653", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10720650", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10684972": { "compartment": "compartment_876", "id": "reaction_10684972", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10684969", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10685927": { "compartment": "compartment_70101", "id": "reaction_10685927", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685923" ], "products": [ "species_113592", "species_10685921" ], "modifiers": [], "additional_components": [ "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10702698": { "compartment": "compartment_70101", "id": "reaction_10702698", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10702695", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10685925": { "compartment": "compartment_70101", "id": "reaction_10685925", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685921" ], "products": [ "species_10685923" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684742": { "compartment": "compartment_876", "id": "reaction_10684742", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10684739", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10715026": { "compartment": "compartment_7660", "id": "reaction_10715026", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715020" ], "products": [ "species_10680330" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10715023": { "compartment": "compartment_7660", "id": "reaction_10715023", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715006", "species_113518" ], "products": [ "species_10715020", "species_10669917" ], "modifiers": [ [ "species_10698755", "catalyst" ], [ "species_10698438", "inhibitor" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10721791": { "compartment": "compartment_70101", "id": "reaction_10721791", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10721783" ], "products": [ "species_29370", "species_10721788" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10717104": { "compartment": "compartment_70101", "id": "reaction_10717104", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680330" ], "products": [ "species_29370", "species_10717102" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10715008": { "compartment": "compartment_70101", "id": "reaction_10715008", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714984" ], "products": [ "species_10715006" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10721861": { "compartment": "compartment_70101", "id": "reaction_10721861", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_10680330" ], "products": [ "species_10721849", "species_197277" ], "modifiers": [ [ "species_10721858", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q86J21", "DDB_G0274293" ] }, "reaction_10721834": { "compartment": "compartment_70101", "id": "reaction_10721834", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689058", "species_113592" ], "products": [ "species_29370", "species_10721832" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721837": { "compartment": "compartment_70101", "id": "reaction_10721837", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715071" ], "modifiers": [ [ "species_10721832", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0281657" ] }, "reaction_10715083": { "compartment": "compartment_70101", "id": "reaction_10715083", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715073", "species_29356" ], "products": [ "species_10670153", "species_10680330" ], "modifiers": [ [ "species_10715080", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10717150": { "compartment": "compartment_70101", "id": "reaction_10717150", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717148" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10721793": { "compartment": "compartment_13231", "id": "reaction_10721793", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721783" ], "products": [ "species_10721781" ], "modifiers": [ [ "species_10677526", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10715054": { "compartment": "compartment_70101", "id": "reaction_10715054", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715043" ], "modifiers": [ [ "species_10715051", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10686632": { "compartment": "compartment_70101", "id": "reaction_10686632", "reactome": "R-DDI-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686100" ], "products": [ "species_10686630" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10686107": { "compartment": "compartment_70101", "id": "reaction_10686107", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10686094" ], "products": [ "species_29370", "species_10686046" ], "modifiers": [ [ "species_10680089", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10686113": { "compartment": "compartment_70101", "id": "reaction_10686113", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686092", "species_450523" ], "products": [ "species_10686094" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10686104": { "compartment": "compartment_70101", "id": "reaction_10686104", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10686094", "species_10685110", "species_10685181" ], "products": [ "species_10686102" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "Q54MG5", "DDB_G0285973", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251" ] }, "reaction_10686050": { "compartment": "compartment_70101", "id": "reaction_10686050", "reactome": "R-DDI-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686046" ], "products": [ "species_10686048" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10679303": { "compartment": "compartment_876", "id": "reaction_10679303", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10679300", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10679314": { "compartment": "compartment_876", "id": "reaction_10679314", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_29590", "species_70113", "species_29532", "species_29590", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10725864": { "compartment": "compartment_70101", "id": "reaction_10725864", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_10701655", "species_994146", "species_994141" ], "products": [ "species_10725862" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994146", "species_1629770", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994141" ] }, "reaction_10725860": { "compartment": "compartment_70101", "id": "reaction_10725860", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_10725858" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "species_113592", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10709720": { "compartment": "compartment_70101", "id": "reaction_10709720", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10709717", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10687988": { "compartment": "compartment_20699", "id": "reaction_10687988", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10687985", "catalyst" ] ], "additional_components": [ "DDB_G0284141" ] }, "reaction_10688162": { "compartment": "compartment_70101", "id": "reaction_10688162", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_947588", "species_29356" ], "products": [ "species_29370", "species_947594", "species_29372" ], "modifiers": [ [ "species_10688101", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500646", "species_1500581", "Q54L55", "DDB_G0286891", "Q553A4", "DDB_G0281401", "Q55E09", "DDB_G0270870", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0281401", "Q551T0", "DDB_G0281401", "Q55E61", "DDB_G0286891" ] }, "reaction_10701952": { "compartment": "compartment_70101", "id": "reaction_10701952", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10701949", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10709709": { "compartment": "compartment_70101", "id": "reaction_10709709", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10709706", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10696020": { "compartment": "compartment_161320", "id": "reaction_10696020", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10696017", "catalyst" ] ], "additional_components": [ "P54639", "DDB_G0278721", "Q559Q3", "DDB_G0291191", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10702333": { "compartment": "compartment_70101", "id": "reaction_10702333", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10702330", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10710970": { "compartment": "compartment_1660541", "id": "reaction_10710970", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710940" ], "products": [ "species_10710968" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10716374": { "compartment": "compartment_70101", "id": "reaction_10716374", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10716371", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10720699": { "compartment": "compartment_161320", "id": "reaction_10720699", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720695", "species_10720691" ], "products": [ "species_10720689", "species_10720697" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q9TVK6", "DDB_G0269158", "species_216762" ] }, "reaction_10710972": { "compartment": "compartment_1660541", "id": "reaction_10710972", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710968" ], "products": [ "species_10710966" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10720693": { "compartment": "compartment_161320", "id": "reaction_10720693", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10720689" ], "products": [ "species_10720691" ], "modifiers": [], "additional_components": [ "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185" ] }, "reaction_10720701": { "compartment": "compartment_12045", "id": "reaction_10720701", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720697" ], "products": [ "species_193384", "species_10720695" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10705109": { "compartment": "compartment_12045", "id": "reaction_10705109", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705051" ], "products": [ "species_10705071" ], "modifiers": [], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10718240": { "compartment": "compartment_876", "id": "reaction_10718240", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718230" ], "products": [ "species_10718238" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10718758": { "compartment": "compartment_70616", "id": "reaction_10718758", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_10718738" ], "products": [ "species_10718750", "species_10718744" ], "modifiers": [ [ "species_10718755", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10677317": { "compartment": "compartment_5460", "id": "reaction_10677317", "reactome": "R-DDI-163296", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677313", "species_10677301" ], "products": [ "species_10677315" ], "modifiers": [], "additional_components": [ "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260", "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260" ] }, "reaction_10677319": { "compartment": "compartment_5460", "id": "reaction_10677319", "reactome": "R-DDI-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10677299" ], "products": [ "species_10677301" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10701526": { "compartment": "compartment_70101", "id": "reaction_10701526", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701518", "species_113592" ], "products": [ "species_29370", "species_10698937" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701523": { "compartment": "compartment_70101", "id": "reaction_10701523", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701516" ], "products": [ "species_10701518", "species_29370" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701651": { "compartment": "compartment_70101", "id": "reaction_10701651", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698939", "species_10701647" ], "products": [ "species_10701649" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10702537": { "compartment": "compartment_876", "id": "reaction_10702537", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698980", "species_5620974" ], "products": [ "species_10702526" ], "modifiers": [ [ "species_10702535", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_1806180", "species_179838", "species_179856", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "species_1806180", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "species_179838", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_179856", "Q54HC6", "DDB_G0289555", "Q8T7K0", "DDB_G0275451", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10701658": { "compartment": "compartment_70101", "id": "reaction_10701658", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_29370", "species_10701655" ], "modifiers": [ [ "species_10701649", "catalyst" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10701653": { "compartment": "compartment_70101", "id": "reaction_10701653", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698937" ], "products": [ "species_10698939" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535" ] }, "reaction_10697256": { "compartment": "compartment_70101", "id": "reaction_10697256", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10683777" ], "products": [ "species_10680149" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10724239": { "compartment": "compartment_17951", "id": "reaction_10724239", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10724169" ], "products": [ "species_10724234", "species_10724236" ], "modifiers": [ [ "species_10724169", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10683109": { "compartment": "compartment_70101", "id": "reaction_10683109", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680440", "species_76577" ], "products": [ "species_10683107" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683111": { "compartment": "compartment_70101", "id": "reaction_10683111", "reactome": "R-DDI-380942", "name": "LKB1 forms a trimeric complex with STRAD and MO25", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680445", "species_10680470", "species_10680454" ], "products": [ "species_10680472" ], "modifiers": [], "additional_components": [ "DDB_G0270680", "Q551H4", "DDB_G0276577", "Q54XL6", "DDB_G0278863", "C7G028", "DDB_G0284307", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10680475": { "compartment": "compartment_70101", "id": "reaction_10680475", "reactome": "R-DDI-200421", "name": "Activation of cytosolic AMPK by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680420", "species_113592" ], "products": [ "species_29370", "species_10680440" ], "modifiers": [ [ "species_10680472", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10685835": { "compartment": "compartment_876", "id": "reaction_10685835", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_113592" ], "products": [ "species_10677585", "species_29370" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10703641": { "compartment": "compartment_17938", "id": "reaction_10703641", "reactome": "R-DDI-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10677539" ], "products": [ "species_10677541" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677561": { "compartment": "compartment_17938", "id": "reaction_10677561", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347", "species_113592" ], "products": [ "species_29370", "species_10677534" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677545", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10702256": { "compartment": "compartment_70101", "id": "reaction_10702256", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10702253", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10677608": { "compartment": "compartment_70101", "id": "reaction_10677608", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677603" ], "products": [ "species_29370", "species_10677606" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "DDB_G0286125" ] }, "reaction_10682921": { "compartment": "compartment_17938", "id": "reaction_10682921", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677545" ], "products": [ "species_29370", "species_10677539" ], "modifiers": [ [ "species_10680774", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10703164": { "compartment": "compartment_17938", "id": "reaction_10703164", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677522", "species_10677461" ], "products": [ "species_10677524" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833" ] }, "reaction_10702550": { "compartment": "compartment_70616", "id": "reaction_10702550", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10702547", "catalyst" ] ], "additional_components": [ "DDB_G0288917" ] }, "reaction_10726000": { "compartment": "compartment_7660", "id": "reaction_10726000", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10721488" ], "products": [ "species_10721490" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677587": { "compartment": "compartment_17938", "id": "reaction_10677587", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677571", "species_113592" ], "products": [ "species_29370", "species_10677575" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677585", "inhibitor" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677598": { "compartment": "compartment_70101", "id": "reaction_10677598", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673172" ], "products": [ "species_29370", "species_10677595" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "DDB_G0286125" ] }, "reaction_10702269": { "compartment": "compartment_70101", "id": "reaction_10702269", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10702266", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10703166": { "compartment": "compartment_70101", "id": "reaction_10703166", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677518", "species_10677490" ], "products": [ "species_10677520" ], "modifiers": [], "additional_components": [ "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10710352": { "compartment": "compartment_70101", "id": "reaction_10710352", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10710349", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10702261": { "compartment": "compartment_70101", "id": "reaction_10702261", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10702258", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10703160": { "compartment": "compartment_17938", "id": "reaction_10703160", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677478", "species_10677473", "species_10677488", "species_10677468", "species_10677483" ], "products": [ "species_10677490" ], "modifiers": [], "additional_components": [ "DDB_G0274833", "DDB_G0291091", "DDB_G0283567", "DDB_G0292160", "DDB_G0291948", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10703650": { "compartment": "compartment_17938", "id": "reaction_10703650", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677541" ], "products": [ "species_29370", "species_10703647" ], "modifiers": [ [ "species_10677541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "P54632", "DDB_G0269138", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677566": { "compartment": "compartment_70101", "id": "reaction_10677566", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677534" ], "products": [ "species_10673316", "species_10677532" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0268574", "DDB_G0291990" ] }, "reaction_10697038": { "compartment": "compartment_70101", "id": "reaction_10697038", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_179856" ], "products": [ "species_10697036" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179856" ] }, "reaction_10721494": { "compartment": "compartment_7660", "id": "reaction_10721494", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721482", "species_1254400" ], "products": [ "species_10721484" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677528": { "compartment": "compartment_70101", "id": "reaction_10677528", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677524", "species_10677442" ], "products": [ "species_10677526" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q550Q4", "DDB_G0277041", "species_29438", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10692083": { "compartment": "compartment_70101", "id": "reaction_10692083", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10692076" ], "products": [ "species_10692080" ], "modifiers": [ [ "species_10692076", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10722291": { "compartment": "compartment_70101", "id": "reaction_10722291", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10677522", "catalyst" ] ], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10725838": { "compartment": "compartment_70101", "id": "reaction_10725838", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677557", "species_9678687" ], "products": [ "species_10677559" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227" ] }, "reaction_10698857": { "compartment": "compartment_20699", "id": "reaction_10698857", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698851" ], "products": [ "species_10698855" ], "modifiers": [], "additional_components": [ "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168" ] }, "reaction_10723074": { "compartment": "compartment_7660", "id": "reaction_10723074", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10723069" ], "products": [ "species_113582", "species_10723071" ], "modifiers": [ [ "species_10723069", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10703162": { "compartment": "compartment_70101", "id": "reaction_10703162", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677503", "species_10677516" ], "products": [ "species_10677518" ], "modifiers": [], "additional_components": [ "species_29438", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701" ] }, "reaction_10677615": { "compartment": "compartment_70101", "id": "reaction_10677615", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673321" ], "products": [ "species_29370", "species_10677613" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "DDB_G0286125" ] }, "reaction_10677444": { "compartment": "compartment_17938", "id": "reaction_10677444", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10677440" ], "products": [ "species_10677442", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q550Q4", "DDB_G0277041", "Q550Q4", "DDB_G0277041", "species_29438" ] }, "reaction_10692085": { "compartment": "compartment_70101", "id": "reaction_10692085", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692080" ], "products": [ "species_10670153", "species_10692072" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689651": { "compartment": "compartment_70101", "id": "reaction_10689651", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689645", "species_10689647" ], "products": [ "species_10689649" ], "modifiers": [], "additional_components": [ "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q9GPS0", "DDB_G0269178", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "P34144", "DDB_G0277869", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10689421": { "compartment": "compartment_70101", "id": "reaction_10689421", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689367" ], "products": [ "species_10689369" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10689432": { "compartment": "compartment_7660", "id": "reaction_10689432", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689428", "species_10689425" ], "products": [ "species_10689430" ], "modifiers": [], "additional_components": [ "DDB_G0267402", "DDB_G0283023", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402" ] }, "reaction_10697214": { "compartment": "compartment_70101", "id": "reaction_10697214", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689440": { "compartment": "compartment_70101", "id": "reaction_10689440", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689423": { "compartment": "compartment_70101", "id": "reaction_10689423", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689374" ], "products": [ "species_10689376" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10689514": { "compartment": "compartment_5460", "id": "reaction_10689514", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10689511", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10684256": { "compartment": "compartment_984", "id": "reaction_10684256", "reactome": "R-DDI-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676753", "species_114570" ], "products": [ "species_10676755" ], "modifiers": [], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335", "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10689443": { "compartment": "compartment_70101", "id": "reaction_10689443", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689499": { "compartment": "compartment_70101", "id": "reaction_10689499", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687040", "species_10689495" ], "products": [ "species_10689497" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920" ] }, "reaction_10687042": { "compartment": "compartment_70101", "id": "reaction_10687042", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687038", "species_10687033" ], "products": [ "species_10687040" ], "modifiers": [], "additional_components": [ "DDB_G0267374", "DDB_G0272104", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10680829": { "compartment": "compartment_70101", "id": "reaction_10680829", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_202277" ], "products": [ "species_10680827" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_202247", "species_179838", "species_202247", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10724241": { "compartment": "compartment_17947", "id": "reaction_10724241", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722369", "species_10724179" ], "products": [ "species_10724181" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724072": { "compartment": "compartment_70101", "id": "reaction_10724072", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724057", "species_10724068" ], "products": [ "species_10724070" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724186": { "compartment": "compartment_17947", "id": "reaction_10724186", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724181" ], "products": [ "species_10690046", "species_10724183" ], "modifiers": [ [ "species_10724181", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724348": { "compartment": "compartment_17947", "id": "reaction_10724348", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724328" ], "products": [ "species_10683511", "species_10724346", "species_10683495" ], "modifiers": [], "additional_components": [ "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "DDB_G0281213" ] }, "reaction_10724616": { "compartment": "compartment_70101", "id": "reaction_10724616", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724612" ], "products": [ "species_10724614" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724509": { "compartment": "compartment_70101", "id": "reaction_10724509", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724505" ], "products": [ "species_10724507" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724173": { "compartment": "compartment_17947", "id": "reaction_10724173", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724151" ], "products": [ "species_10722365", "species_10724171" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724195": { "compartment": "compartment_70101", "id": "reaction_10724195", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724192", "species_29356" ], "products": [ "species_10670153", "species_10724145", "species_10717909" ], "modifiers": [ [ "species_10724192", "catalyst" ] ], "additional_components": [ "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286033", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724232": { "compartment": "compartment_17947", "id": "reaction_10724232", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724222" ], "products": [ "species_10724179", "species_10724230" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "O96759", "DDB_G0286183", "Q54N40", "DDB_G0285523", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724352": { "compartment": "compartment_70101", "id": "reaction_10724352", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683511", "species_10724324" ], "products": [ "species_10724326" ], "modifiers": [], "additional_components": [ "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10724218": { "compartment": "compartment_70101", "id": "reaction_10724218", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724190", "species_10717909" ], "products": [ "species_10724192" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724175": { "compartment": "compartment_17947", "id": "reaction_10724175", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724147", "species_10724149" ], "products": [ "species_10724151" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724350": { "compartment": "compartment_17947", "id": "reaction_10724350", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683495", "species_10724326" ], "products": [ "species_10724328" ], "modifiers": [], "additional_components": [ "DDB_G0281213", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10701703": { "compartment": "compartment_70101", "id": "reaction_10701703", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701694" ], "products": [ "species_10701701" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10702088": { "compartment": "compartment_70101", "id": "reaction_10702088", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10702085", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10702104": { "compartment": "compartment_70101", "id": "reaction_10702104", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702101", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10702099": { "compartment": "compartment_70101", "id": "reaction_10702099", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702096", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10721599": { "compartment": "compartment_70101", "id": "reaction_10721599", "reactome": "R-DDI-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10721596", "catalyst" ] ], "additional_components": [ "species_188972", "species_209818", "species_188972", "species_209818", "Q54PM1", "DDB_G0284461" ] }, "reaction_10701711": { "compartment": "compartment_70101", "id": "reaction_10701711", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701707" ], "products": [ "species_10701709" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10675618": { "compartment": "compartment_7660", "id": "reaction_10675618", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10675608" ], "products": [ "species_10675615", "species_111349" ], "modifiers": [ [ "species_10675608", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675632": { "compartment": "compartment_7660", "id": "reaction_10675632", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675625", "species_77087" ], "products": [ "species_10673970", "species_10672159", "species_10675598", "species_10675629", "species_77502" ], "modifiers": [ [ "species_10675625", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0287661", "Q54Y13", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675623": { "compartment": "compartment_7660", "id": "reaction_10675623", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675615" ], "products": [ "species_10675620" ], "modifiers": [ [ "species_10675615", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675606": { "compartment": "compartment_7660", "id": "reaction_10675606", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_10675600", "species_29428" ], "products": [ "species_10675604" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675634": { "compartment": "compartment_7660", "id": "reaction_10675634", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672073", "species_10672078" ], "products": [ "species_10672080" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10675611": { "compartment": "compartment_7660", "id": "reaction_10675611", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675604" ], "products": [ "species_113550", "species_10675608" ], "modifiers": [ [ "species_10675604", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675627": { "compartment": "compartment_7660", "id": "reaction_10675627", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675620" ], "products": [ "species_10675625" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675636": { "compartment": "compartment_7660", "id": "reaction_10675636", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672080", "species_10672159" ], "products": [ "species_10672161" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10711945": { "compartment": "compartment_7660", "id": "reaction_10711945", "reactome": "R-DDI-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10711942" ], "products": [ "species_2485002", "species_10704963" ], "modifiers": [ [ "species_10711942", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10722637": { "compartment": "compartment_7660", "id": "reaction_10722637", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10698776" ], "products": [ "species_10698778" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10698781": { "compartment": "compartment_7660", "id": "reaction_10698781", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10698769" ], "products": [ "species_159939", "species_10698771" ], "modifiers": [ [ "species_10698778", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10704968": { "compartment": "compartment_7660", "id": "reaction_10704968", "reactome": "R-DDI-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10704963" ], "products": [ "species_113582", "species_10704965", "species_10682355" ], "modifiers": [ [ "species_10704963", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10718247": { "compartment": "compartment_984", "id": "reaction_10718247", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10718244", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10712967": { "compartment": "compartment_6800173", "id": "reaction_10712967", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712871" ], "products": [ "species_10712965" ], "modifiers": [], "additional_components": [ "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q65YR8", "DDB_G0291834", "Q54V78", "DDB_G0349530", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q65YR7", "DDB_G0280439", "Q54RQ2", "DDB_G0282991", "Q54Q34", "DDB_G0349530", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490", "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q54V78", "DDB_G0349530", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q54RQ2", "DDB_G0282991", "Q65YR7", "DDB_G0280439", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490" ] }, "reaction_10711257": { "compartment": "compartment_21994", "id": "reaction_10711257", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711254", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10714086": { "compartment": "compartment_1470028", "id": "reaction_10714086", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713952" ], "products": [ "species_10714084" ], "modifiers": [], "additional_components": [ "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179", "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179" ] }, "reaction_10714758": { "compartment": "compartment_984", "id": "reaction_10714758", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714736" ], "products": [ "species_10714756" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10712473": { "compartment": "compartment_6798757", "id": "reaction_10712473", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712371" ], "products": [ "species_10712471" ], "modifiers": [], "additional_components": [ "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791" ] }, "reaction_10686832": { "compartment": "compartment_70101", "id": "reaction_10686832", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677800" ], "products": [ "species_10677804" ], "modifiers": [], "additional_components": [ "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10686854": { "compartment": "compartment_70101", "id": "reaction_10686854", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677816" ], "products": [ "species_10677818" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10711262": { "compartment": "compartment_21994", "id": "reaction_10711262", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10711252" ], "products": [ "species_10711254" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10721333": { "compartment": "compartment_1222282", "id": "reaction_10721333", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677802": { "compartment": "compartment_70101", "id": "reaction_10677802", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677798", "species_622271" ], "products": [ "species_10677800" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10713614": { "compartment": "compartment_1462052", "id": "reaction_10713614", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713428" ], "products": [ "species_10713612" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10711260": { "compartment": "compartment_1222282", "id": "reaction_10711260", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677848": { "compartment": "compartment_70101", "id": "reaction_10677848", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10677814" ], "products": [ "species_10677816" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10713716": { "compartment": "compartment_6799371", "id": "reaction_10713716", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713682" ], "products": [ "species_10713714" ], "modifiers": [], "additional_components": [ "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54V78", "DDB_G0349530", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q55BA2", "DDB_G0271242", "Q6UK63", "DDB_G0287855", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54B14", "DDB_G0293986", "Q556T3", "DDB_G0273107", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490", "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q54V78", "DDB_G0349530", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q6UK63", "DDB_G0287855", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490" ] }, "reaction_10714477": { "compartment": "compartment_6800424", "id": "reaction_10714477", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714461" ], "products": [ "species_10714475" ], "modifiers": [], "additional_components": [ "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735", "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735" ] }, "reaction_10689989": { "compartment": "compartment_1222693", "id": "reaction_10689989", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10689986", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10725834": { "compartment": "compartment_70101", "id": "reaction_10725834", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725772", "species_10677814" ], "products": [ "species_10725832" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55E90", "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10714292": { "compartment": "compartment_6799351", "id": "reaction_10714292", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714270" ], "products": [ "species_10714290" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013", "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013" ] }, "reaction_10677846": { "compartment": "compartment_70101", "id": "reaction_10677846", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677842", "species_10677820" ], "products": [ "species_10677844" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54HC6", "DDB_G0289555", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54XX5", "DDB_G0278535" ] }, "reaction_10712733": { "compartment": "compartment_876", "id": "reaction_10712733", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712651" ], "products": [ "species_10712731" ], "modifiers": [], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735", "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735" ] }, "reaction_10713133": { "compartment": "compartment_6799713", "id": "reaction_10713133", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713083" ], "products": [ "species_10713131" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "Q54F59", "DDB_G0291091", "P03967", "DDB_G0292996", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q86A88", "DDB_G0274815", "Q54YE6", "DDB_G0284903", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "Q86A88", "DDB_G0274815", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735" ] }, "reaction_10686034": { "compartment": "compartment_70101", "id": "reaction_10686034", "reactome": "R-DDI-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686030" ], "products": [ "species_10686032" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686715": { "compartment": "compartment_7660", "id": "reaction_10686715", "reactome": "R-DDI-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10686131" ], "products": [ "species_10686713" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686719": { "compartment": "compartment_7660", "id": "reaction_10686719", "reactome": "R-DDI-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686123", "species_517622" ], "products": [ "species_10686717" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686111": { "compartment": "compartment_7660", "id": "reaction_10686111", "reactome": "R-DDI-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450613", "species_10672405" ], "products": [ "species_10686109" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686040": { "compartment": "compartment_70101", "id": "reaction_10686040", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686021", "species_10686036", "species_450597" ], "products": [ "species_10686038" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686059": { "compartment": "compartment_70101", "id": "reaction_10686059", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10685110", "species_10685181", "species_10686038" ], "products": [ "species_10686057" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10699437": { "compartment": "compartment_70101", "id": "reaction_10699437", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699426" ], "products": [ "species_29370", "species_10699429" ], "modifiers": [ [ "species_10699434", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10699539": { "compartment": "compartment_70101", "id": "reaction_10699539", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699537" ], "products": [ "species_10699479", "species_10699426", "species_10682231" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10699547": { "compartment": "compartment_70101", "id": "reaction_10699547", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699426" ], "products": [ "species_10699491" ], "modifiers": [ [ "species_10676967", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10699508": { "compartment": "compartment_7660", "id": "reaction_10699508", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684694", "species_10699504" ], "products": [ "species_10699506" ], "modifiers": [], "additional_components": [ "DDB_G0289967", "DDB_G0274577", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10700882": { "compartment": "compartment_70101", "id": "reaction_10700882", "reactome": "R-DDI-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700878", "species_10674717" ], "products": [ "species_10700880" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54UC1", "DDB_G0281165" ] }, "reaction_10701046": { "compartment": "compartment_7660", "id": "reaction_10701046", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701044" ], "products": [ "species_10701042", "species_10701017", "species_10701036" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10701966": { "compartment": "compartment_70101", "id": "reaction_10701966", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10701961" ], "products": [ "species_10699479", "species_10699426", "species_10682231", "species_10701963" ], "modifiers": [ [ "species_10701961", "catalyst" ] ], "additional_components": [ "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042", "P90532", "DDB_G0288065", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699522": { "compartment": "compartment_7660", "id": "reaction_10699522", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10699510" ], "products": [ "species_113582", "species_10699504" ], "modifiers": [ [ "species_10699519", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "Q553E9", "DDB_G0275845", "Q54ER4", "DDB_G0291380" ] }, "reaction_10701019": { "compartment": "compartment_7660", "id": "reaction_10701019", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701017" ], "products": [ "species_10699495" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699497": { "compartment": "compartment_70101", "id": "reaction_10699497", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699491" ], "products": [ "species_10699495" ], "modifiers": [ [ "species_10674717", "inhibitor" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P54632", "DDB_G0269138" ] }, "reaction_10675699": { "compartment": "compartment_7660", "id": "reaction_10675699", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675693", "species_10672837" ], "products": [ "species_10675697" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q54LG7", "DDB_G0286645", "Q54XS9", "DDB_G0278769", "Q54V94", "DDB_G0280529", "Q54LG7", "DDB_G0286645", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54XS9", "DDB_G0278769", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q54V94", "DDB_G0280529", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10675695": { "compartment": "compartment_7660", "id": "reaction_10675695", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672816", "species_10675691" ], "products": [ "species_10675693" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q54TS6", "DDB_G0281585", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10697903": { "compartment": "compartment_70101", "id": "reaction_10697903", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697893", "species_2534019" ], "products": [ "species_76194", "species_10674265" ], "modifiers": [ [ "species_10697898", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "DDB_G0275863" ] }, "reaction_10674540": { "compartment": "compartment_2514888", "id": "reaction_10674540", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10674512", "catalyst" ], [ "species_10674532", "catalyst" ], [ "species_10674534", "catalyst" ], [ "species_10674536", "inhibitor" ], [ "species_10674530", "inhibitor" ], [ "species_10674538", "inhibitor" ] ], "additional_components": [ "Q553Y7", "DDB_G0275009", "Q03101", "DDB_G0274569", "DDB_G0275931", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10698058": { "compartment": "compartment_70101", "id": "reaction_10698058", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10674518" ], "products": [ "species_10674530" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10697932": { "compartment": "compartment_70101", "id": "reaction_10697932", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697913" ], "products": [ "species_10697893", "species_174390" ], "modifiers": [ [ "species_10697929", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10685127": { "compartment": "compartment_70101", "id": "reaction_10685127", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685092", "species_429974" ], "products": [ "species_10685094" ], "modifiers": [], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453" ] }, "reaction_10685125": { "compartment": "compartment_70101", "id": "reaction_10685125", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685094", "species_29356" ], "products": [ "species_10685096", "species_430004" ], "modifiers": [ [ "species_10685122", "catalyst" ] ], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q54R87", "DDB_G0283315", "Q54KM1", "DDB_G0287243", "Q54J96", "DDB_G0288241", "Q54E49", "DDB_G0291804" ] }, "reaction_10683236": { "compartment": "compartment_12045", "id": "reaction_10683236", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683208", "species_113592" ], "products": [ "species_29370", "species_10683233" ], "modifiers": [ [ "species_10683208", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10683169": { "compartment": "compartment_12045", "id": "reaction_10683169", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683158" ], "products": [ "species_10683167" ], "modifiers": [], "additional_components": [ "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10683136": { "compartment": "compartment_70101", "id": "reaction_10683136", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683128" ], "products": [ "species_10683134" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683288": { "compartment": "compartment_12045", "id": "reaction_10683288", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683284" ], "products": [ "species_10683258" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683246": { "compartment": "compartment_70101", "id": "reaction_10683246", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_113592" ], "products": [ "species_29370", "species_10683243" ], "modifiers": [ [ "species_10683167", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10684272": { "compartment": "compartment_20699", "id": "reaction_10684272", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683264" ], "products": [ "species_10684264", "species_10683128" ], "modifiers": [ [ "species_10684269", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10683278": { "compartment": "compartment_20699", "id": "reaction_10683278", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683258" ], "products": [ "species_10683264", "species_10683270" ], "modifiers": [ [ "species_10683275", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0270252" ] }, "reaction_10683238": { "compartment": "compartment_12045", "id": "reaction_10683238", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683206" ], "products": [ "species_10683208" ], "modifiers": [], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10682271": { "compartment": "compartment_984", "id": "reaction_10682271", "reactome": "R-DDI-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10682267" ], "products": [ "species_10682269" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657", "species_265479", "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657" ] }, "reaction_10687765": { "compartment": "compartment_70101", "id": "reaction_10687765", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687761", "species_10687744" ], "products": [ "species_10687763", "species_10687742" ], "modifiers": [], "additional_components": [ "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55DV8", "DDB_G0269510", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DV8", "DDB_G0269510", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295" ] }, "reaction_10718224": { "compartment": "compartment_262783", "id": "reaction_10718224", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718207", "species_10718220", "species_10718215" ], "products": [ "species_10718222" ], "modifiers": [], "additional_components": [ "DDB_G0269238", "DDB_G0269130", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "P36412", "DDB_G0269238", "O96904", "DDB_G0269130", "Q54R95", "DDB_G0283337" ] }, "reaction_10718103": { "compartment": "compartment_17938", "id": "reaction_10718103", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718076", "species_29356" ], "products": [ "species_10718078", "species_29372" ], "modifiers": [ [ "species_10718076", "catalyst" ], [ "species_10718101", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "CHEBI:15996", "species_29420", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "CHEBI:15996", "Q54WP7", "DDB_G0295717", "Q75JG4", "DDB_G0276119", "C7G032", "DDB_G0295717", "Q553Q2", "DDB_G0295717" ] }, "reaction_10718045": { "compartment": "compartment_24339", "id": "reaction_10718045", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718015" ], "products": [ "species_10718017", "species_29372" ], "modifiers": [ [ "species_10718015", "catalyst" ], [ "species_10718043", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "species_29420", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q55F14", "DDB_G0269052", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421" ] }, "reaction_10718182": { "compartment": "compartment_5683628", "id": "reaction_10718182", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718176", "species_10718178" ], "products": [ "species_10718180" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q54IE1", "DDB_G0288811", "Q86CR8", "DDB_G0286191" ] }, "reaction_10718193": { "compartment": "compartment_437051", "id": "reaction_10718193", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718188", "species_29356" ], "products": [ "species_29372", "species_10718190" ], "modifiers": [ [ "species_10718188", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "CHEBI:15996", "Q54DA7", "DDB_G0292406", "species_111349", "Q54DA7", "DDB_G0292406", "CHEBI:15996" ] }, "reaction_10718058": { "compartment": "compartment_19363", "id": "reaction_10718058", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718048", "species_10718054" ], "products": [ "species_10718056" ], "modifiers": [], "additional_components": [ "DDB_G0282977", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q54RR0", "DDB_G0282977" ] }, "reaction_10718135": { "compartment": "compartment_20699", "id": "reaction_10718135", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718131", "species_10716961" ], "products": [ "species_10718133" ], "modifiers": [], "additional_components": [ "Q54H32", "DDB_G0289735", "Q54KE5", "DDB_G0289735", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "species_29438", "Q54H32", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "Q54KE5", "DDB_G0289735", "species_29438", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735" ] }, "reaction_10687717": { "compartment": "compartment_74700", "id": "reaction_10687717", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687496", "species_113592" ], "products": [ "species_29370", "species_10687276", "species_10687698", "species_10687290", "species_10687285", "species_29372", "species_10687266", "species_10687271" ], "modifiers": [ [ "species_10687714", "catalyst" ] ], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "DDB_G0275573", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "species_179838", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0287993", "DDB_G0287021", "DDB_G0290087", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q54PT2", "DDB_G0284347", "Q55B11", "DDB_G0271488" ] }, "reaction_10687767": { "compartment": "compartment_70101", "id": "reaction_10687767", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687763", "species_10687292" ], "products": [ "species_10687496", "species_10687761" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708" ] }, "reaction_10718204": { "compartment": "compartment_5683628", "id": "reaction_10718204", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718199" ], "products": [ "species_10718201", "species_29372" ], "modifiers": [ [ "species_10718199", "catalyst" ], [ "species_10718178", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "species_29420", "O76173", "DDB_G0269174", "O76173", "DDB_G0269174", "species_29438", "DDB_G0288811" ] }, "reaction_10718173": { "compartment": "compartment_17938", "id": "reaction_10718173", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718163", "species_29356" ], "products": [ "species_10718165", "species_29372" ], "modifiers": [ [ "species_10718163", "catalyst" ], [ "species_10718171", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_111349", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "DDB_G0288811" ] }, "reaction_10722615": { "compartment": "compartment_70101", "id": "reaction_10722615", "reactome": "R-DDI-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674492" ], "products": [ "species_10674488", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q54YX3", "DDB_G0278031", "DDB_G0278031" ] }, "reaction_10697511": { "compartment": "compartment_70101", "id": "reaction_10697511", "reactome": "R-DDI-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674488", "species_30927" ], "products": [ "species_10674490" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_30927", "Q54YX3", "DDB_G0278031" ] }, "reaction_10709524": { "compartment": "compartment_70101", "id": "reaction_10709524", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10709517", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] }, "reaction_10709660": { "compartment": "compartment_70101", "id": "reaction_10709660", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10709521" ], "products": [ "species_10709651" ], "modifiers": [ [ "species_10709657", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0279159", "DDB_G0279159", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10709669": { "compartment": "compartment_70101", "id": "reaction_10709669", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10678831" ], "products": [ "species_10709667" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "DDB_G0267384", "Q86KD1", "DDB_G0274167", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10709519": { "compartment": "compartment_70101", "id": "reaction_10709519", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10709515" ], "products": [ "species_10709517" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10687777": { "compartment": "compartment_74700", "id": "reaction_10687777", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10687774", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10687769": { "compartment": "compartment_74700", "id": "reaction_10687769", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] } }, "motif_reaction_dictionary": { "reaction_10677351": { "compartment": "compartment_7660", "id": "reaction_10677351", "reactome": "R-DDI-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674916" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10677345": { "compartment": "compartment_7660", "id": "reaction_10677345", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10674902" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10677349": { "compartment": "compartment_7660", "id": "reaction_10677349", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10677347" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10696321": { "compartment": "compartment_876", "id": "reaction_10696321", "reactome": "R-DDI-2167942", "name": "Collagen type XIII ectodomain shedding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696053" ], "products": [ "species_10696319", "species_10696293" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696409": { "compartment": "compartment_984", "id": "reaction_10696409", "reactome": "R-DDI-2168038", "name": "Collagen type XV restin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696351" ], "products": [ "species_10696407", "species_10696403" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697814": { "compartment": "compartment_984", "id": "reaction_10697814", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695841" ], "products": [ "species_10697743" ], "modifiers": [ [ "species_10697811", "catalyst" ] ], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696557": { "compartment": "compartment_984", "id": "reaction_10696557", "reactome": "R-DDI-2168923", "name": "Collagen type XVIII endostatin release", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696458" ], "products": [ "species_10696464", "species_10696490" ], "modifiers": [ [ "species_10696554", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10696587": { "compartment": "compartment_984", "id": "reaction_10696587", "reactome": "R-DDI-2172433", "name": "Collagen type XIX degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696585" ], "products": [], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585" ] }, "reaction_10697697": { "compartment": "compartment_984", "id": "reaction_10697697", "reactome": "R-DDI-2471621", "name": "Endostatin degradation by cathepsins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696490" ], "products": [], "modifiers": [ [ "species_10697694", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10700000": { "compartment": "compartment_984", "id": "reaction_10700000", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692323" ], "products": [ "species_10699995", "species_10699997" ], "modifiers": [ [ "species_10696532", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10677776": { "compartment": "compartment_70101", "id": "reaction_10677776", "reactome": "R-DDI-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677695" ], "products": [ "species_10677763", "species_29370" ], "modifiers": [ [ "species_10677773", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54HS0", "DDB_G0289277" ] }, "reaction_10721800": { "compartment": "compartment_70101", "id": "reaction_10721800", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685829" ], "products": [ "species_10680841", "species_10721798" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10710974": { "compartment": "compartment_70101", "id": "reaction_10710974", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689687" ], "products": [ "species_10689719" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722948": { "compartment": "compartment_70101", "id": "reaction_10722948", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722934" ], "products": [ "species_10722946" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711315": { "compartment": "compartment_17957", "id": "reaction_10711315", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10711313" ], "modifiers": [ [ "species_10689719", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721951": { "compartment": "compartment_70101", "id": "reaction_10721951", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721937" ], "products": [ "species_10721949" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711217": { "compartment": "compartment_70101", "id": "reaction_10711217", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711213" ], "products": [ "species_10711215" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689919": { "compartment": "compartment_70101", "id": "reaction_10689919", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689914", "species_10689903" ], "products": [ "species_10689901", "species_10687967", "species_111294", "species_76577", "species_10689916" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54FR5", "DDB_G0290629", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10722886": { "compartment": "compartment_70101", "id": "reaction_10722886", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722870" ], "products": [ "species_10722884" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689924": { "compartment": "compartment_70101", "id": "reaction_10689924", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689905", "species_10687967" ], "products": [ "species_10689897", "species_10687972" ], "modifiers": [ [ "species_10687967", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0270272", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10723442": { "compartment": "compartment_984", "id": "reaction_10723442", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10682859" ], "products": [ "species_10723440" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10722811": { "compartment": "compartment_70101", "id": "reaction_10722811", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722797" ], "products": [ "species_10722809" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10689723": { "compartment": "compartment_70101", "id": "reaction_10689723", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689691" ], "products": [ "species_10689721" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10687013": { "compartment": "compartment_7660", "id": "reaction_10687013", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687009", "species_10686997", "species_10686965" ], "products": [ "species_10687011" ], "modifiers": [], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q8N0B4", "DDB_G0286189", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q555X5", "DDB_G0274743", "O00910", "DDB_G0281381", "Q55FZ7", "DDB_G0267886", "Q54BD4", "DDB_G0293532", "Q54V57", "DDB_G0280603" ] }, "reaction_10721796": { "compartment": "compartment_70101", "id": "reaction_10721796", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685818", "species_10685820" ], "products": [ "species_10685822" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722845": { "compartment": "compartment_70101", "id": "reaction_10722845", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722809" ], "products": [ "species_10722843" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685968": { "compartment": "compartment_70101", "id": "reaction_10685968", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685956", "species_113592" ], "products": [ "species_29370", "species_10677773" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10726042": { "compartment": "compartment_70101", "id": "reaction_10726042", "reactome": "R-DDI-9710959", "name": "p-STAT1 dimer binds KPNA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726002", "species_10687129" ], "products": [ "species_10726040" ], "modifiers": [], "additional_components": [ "DDB_G0273149", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q557F4", "DDB_G0273149" ] }, "reaction_10710976": { "compartment": "compartment_70101", "id": "reaction_10710976", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683" ], "products": [ "species_10689687" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721987": { "compartment": "compartment_70101", "id": "reaction_10721987", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721983" ], "products": [ "species_10721985" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721981": { "compartment": "compartment_70101", "id": "reaction_10721981", "reactome": "R-DDI-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721977" ], "products": [ "species_10721979" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685976": { "compartment": "compartment_70101", "id": "reaction_10685976", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685974" ], "products": [ "species_29370", "species_10685942" ], "modifiers": [ [ "species_10685965", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10689693": { "compartment": "compartment_70101", "id": "reaction_10689693", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689685" ], "products": [ "species_10689691" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685950": { "compartment": "compartment_70101", "id": "reaction_10685950", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685942" ], "products": [ "species_10685948" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10722868": { "compartment": "compartment_70101", "id": "reaction_10722868", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722797" ], "products": [ "species_10722866" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722872": { "compartment": "compartment_70101", "id": "reaction_10722872", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722807", "species_10722860" ], "products": [ "species_10722870" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721989": { "compartment": "compartment_70101", "id": "reaction_10721989", "reactome": "R-DDI-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689689" ], "products": [ "species_10689717" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686004": { "compartment": "compartment_70101", "id": "reaction_10686004", "reactome": "R-DDI-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677763" ], "products": [ "species_10686002" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10718623": { "compartment": "compartment_7660", "id": "reaction_10718623", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718594", "species_10718601" ], "products": [ "species_10718621" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0267402", "Q54MP8", "DDB_G0285837", "O15819", "DDB_G0267402" ] }, "reaction_10685884": { "compartment": "compartment_984", "id": "reaction_10685884", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10685874" ], "products": [ "species_10685876" ], "modifiers": [ [ "species_10685882", "inhibitor" ] ], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231", "Q54YE6", "DDB_G0284903", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q54QC8", "DDB_G0283937", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10693415": { "compartment": "compartment_70101", "id": "reaction_10693415", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693390", "species_10689903" ], "products": [ "species_10693392" ], "modifiers": [], "additional_components": [ "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979" ] }, "reaction_10685832": { "compartment": "compartment_70101", "id": "reaction_10685832", "reactome": "R-DDI-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685822" ], "products": [ "species_10685829" ], "modifiers": [ [ "species_10685822", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q559R2", "DDB_G0272454", "Q54TK0", "DDB_G0281703", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q559R2", "DDB_G0272454", "P14794", "DDB_G0280755" ] }, "reaction_10722864": { "compartment": "compartment_70101", "id": "reaction_10722864", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722860" ], "products": [ "species_10722862" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10693413": { "compartment": "compartment_70101", "id": "reaction_10693413", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693409", "species_10693392" ], "products": [ "species_10693411", "species_10693407" ], "modifiers": [], "additional_components": [ "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54T63", "DDB_G0281979", "Q55D61", "DDB_G0269192", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q55BQ5", "DDB_G0270406" ] }, "reaction_10686967": { "compartment": "compartment_13231", "id": "reaction_10686967", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686953" ], "products": [ "species_10686965" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722952": { "compartment": "compartment_70101", "id": "reaction_10722952", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722932" ], "products": [ "species_10722934" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10685932": { "compartment": "compartment_70101", "id": "reaction_10685932", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685816", "species_10685814" ], "products": [ "species_10685818" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10680392": { "compartment": "compartment_7660", "id": "reaction_10680392", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10680389", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10718598": { "compartment": "compartment_7660", "id": "reaction_10718598", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698721", "species_10718594" ], "products": [ "species_10718596" ], "modifiers": [], "additional_components": [ "DDB_G0285205", "DDB_G0285837", "Q54MP8", "DDB_G0285837", "Q55C32", "DDB_G0285205" ] }, "reaction_10689908": { "compartment": "compartment_70101", "id": "reaction_10689908", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687972", "species_10687957", "species_113592" ], "products": [ "species_10689905", "species_111294", "species_76577" ], "modifiers": [ [ "species_10687972", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10721991": { "compartment": "compartment_70101", "id": "reaction_10721991", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721935" ], "products": [ "species_10721937" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10686171": { "compartment": "compartment_70101", "id": "reaction_10686171", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686160" ], "products": [ "species_10686168" ], "modifiers": [ [ "species_10686160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54LU8", "DDB_G0286465", "P0CG79", "DDB_G0282369", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10722999": { "compartment": "compartment_70101", "id": "reaction_10722999", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683071", "species_113592" ], "products": [ "species_10722807", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711221": { "compartment": "compartment_70101", "id": "reaction_10711221", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711215" ], "products": [ "species_10711219" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721993": { "compartment": "compartment_70101", "id": "reaction_10721993", "reactome": "R-DDI-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10721935" ], "products": [ "species_10721983" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722966": { "compartment": "compartment_70101", "id": "reaction_10722966", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722920" ], "products": [ "species_10722964" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10711033": { "compartment": "compartment_70101", "id": "reaction_10711033", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711027" ], "products": [ "species_10711031" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10721995": { "compartment": "compartment_70101", "id": "reaction_10721995", "reactome": "R-DDI-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689683", "species_10687127" ], "products": [ "species_10689689" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10722989": { "compartment": "compartment_984", "id": "reaction_10722989", "reactome": "R-DDI-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10689912": { "compartment": "compartment_70101", "id": "reaction_10689912", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687957", "species_10688804" ], "products": [ "species_10689910" ], "modifiers": [], "additional_components": [ "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063", "Q54CI1", "DDB_G0292984", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10689954": { "compartment": "compartment_70101", "id": "reaction_10689954", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689950", "species_10689903" ], "products": [ "species_10689901", "species_10689952", "species_10687967", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689903", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10693385": { "compartment": "compartment_70101", "id": "reaction_10693385", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689952" ], "products": [ "species_141681", "species_10689950" ], "modifiers": [ [ "species_10693382", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q54CI1", "DDB_G0292984", "Q94464", "DDB_G0277849", "Q86I20", "DDB_G0275167", "Q54R98", "DDB_G0295843", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q55DK2", "DDB_G0295843", "Q70GP4", "DDB_G0268638", "Q86L44", "DDB_G0294407", "O00910", "DDB_G0281381", "Q9U1M9", "DDB_G0277851", "Q54FR5", "DDB_G0290629", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q94464", "DDB_G0277849", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q86L44", "DDB_G0294407", "Q54R98", "DDB_G0295843", "O00910", "DDB_G0281381", "Q54TE1", "DDB_G0290629", "Q54BD4", "DDB_G0293532", "Q54H96", "DDB_G0289611" ] }, "reaction_10711065": { "compartment": "compartment_70101", "id": "reaction_10711065", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711031" ], "products": [ "species_10711063" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10723438": { "compartment": "compartment_984", "id": "reaction_10723438", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685868", "species_10723434" ], "products": [ "species_10723436" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10689921": { "compartment": "compartment_70101", "id": "reaction_10689921", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689901", "species_10689897" ], "products": [ "species_10689903" ], "modifiers": [], "additional_components": [ "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54XG4", "DDB_G0292642", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10681044": { "compartment": "compartment_7660", "id": "reaction_10681044", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10680378" ], "products": [ "species_113550", "species_10680382" ], "modifiers": [ [ "species_10681041", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54CK7", "DDB_G0292880", "Q55CS8", "DDB_G0270688", "Q55CS7", "DDB_G0269918", "Q8T813", "DDB_G0292880", "Q54N84", "DDB_G0292880", "Q55BI8", "DDB_G0292880", "Q556Y8", "DDB_G0292880" ] }, "reaction_10722922": { "compartment": "compartment_70101", "id": "reaction_10722922", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721965" ], "products": [ "species_10722920" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10700120": { "compartment": "compartment_70101", "id": "reaction_10700120", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10700111" ], "products": [ "species_29370", "species_10700117" ], "modifiers": [ [ "species_10700111", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10700113": { "compartment": "compartment_876", "id": "reaction_10700113", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681384", "species_10683631" ], "products": [ "species_10700111" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10680511": { "compartment": "compartment_70101", "id": "reaction_10680511", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674849", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10686784": { "compartment": "compartment_70101", "id": "reaction_10686784", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_29366", "species_548836" ], "modifiers": [ [ "species_10686781", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10686779": { "compartment": "compartment_70101", "id": "reaction_10686779", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548794", "species_29508" ], "products": [ "species_76194", "species_113528", "species_548829" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10680602": { "compartment": "compartment_70101", "id": "reaction_10680602", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_3632881", "species_113592" ], "products": [ "species_111294", "species_76577", "species_29356", "species_200993" ], "modifiers": [ [ "species_10680599", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10718402": { "compartment": "compartment_5460", "id": "reaction_10718402", "reactome": "R-DDI-8862152", "name": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8862377", "species_113600", "species_113529" ], "products": [ "species_113563", "species_8862371" ], "modifiers": [ [ "species_10718399", "catalyst" ] ], "additional_components": [ "Q75JT8", "DDB_G0272154", "Q55E82", "DDB_G0269356" ] }, "reaction_10710291": { "compartment": "compartment_70101", "id": "reaction_10710291", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_5695985", "species_113592" ], "products": [ "species_5695971", "species_111294", "species_76577" ], "modifiers": [ [ "species_10710288", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10686794": { "compartment": "compartment_70101", "id": "reaction_10686794", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_29366", "species_428139" ], "modifiers": [ [ "species_10686789", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10674838": { "compartment": "compartment_70101", "id": "reaction_10674838", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_76190", "species_113592" ], "products": [ "species_29370", "species_76213", "species_29372", "species_76183" ], "modifiers": [ [ "species_10674835", "catalyst" ] ], "additional_components": [ "Q54YA0", "DDB_G0278345" ] }, "reaction_10677353": { "compartment": "compartment_70101", "id": "reaction_10677353", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674902" ], "products": [ "species_10674904" ], "modifiers": [], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10709494": { "compartment": "compartment_161320", "id": "reaction_10709494", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690533", "species_1605715" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10709491", "catalyst" ] ], "additional_components": [ "species_6785219", "species_400452", "DDB_G0288807" ] }, "reaction_10710299": { "compartment": "compartment_5460", "id": "reaction_10710299", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_5696003", "species_159450" ], "modifiers": [ [ "species_10710296", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10686768": { "compartment": "compartment_70101", "id": "reaction_10686768", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548819" ], "products": [ "species_76194", "species_548816", "species_113528" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10674907": { "compartment": "compartment_70101", "id": "reaction_10674907", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29508", "species_76183" ], "products": [ "species_76194", "species_29366", "species_3632881", "species_113528", "species_29356" ], "modifiers": [ [ "species_10674904", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077" ] }, "reaction_10686777": { "compartment": "compartment_70101", "id": "reaction_10686777", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_76194", "species_113528", "species_548812" ], "modifiers": [ [ "species_10686774", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10709097": { "compartment": "compartment_161320", "id": "reaction_10709097", "reactome": "R-DDI-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10709094", "catalyst" ] ], "additional_components": [ "Q54N35", "DDB_G0288807", "Q54IE5", "DDB_G0288807" ] }, "reaction_10722585": { "compartment": "compartment_5460", "id": "reaction_10722585", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10722582", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10704723": { "compartment": "compartment_12045", "id": "reaction_10704723", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_5676634", "species_29356" ], "modifiers": [ [ "species_10704720", "catalyst" ] ], "additional_components": [ "Q54YR9", "DDB_G0278113", "Q54Y54", "DDB_G0278683" ] }, "reaction_10723486": { "compartment": "compartment_70101", "id": "reaction_10723486", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_9014643", "species_29356" ], "modifiers": [ [ "species_10723483", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10723494": { "compartment": "compartment_70101", "id": "reaction_10723494", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10723491", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10724544": { "compartment": "compartment_74700", "id": "reaction_10724544", "reactome": "R-DDI-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724541", "species_113592" ], "products": [ "species_29370", "species_10724523" ], "modifiers": [ [ "species_10724541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "species_29426", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10680187": { "compartment": "compartment_7660", "id": "reaction_10680187", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680183" ], "products": [ "species_10680185" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10724539": { "compartment": "compartment_70101", "id": "reaction_10724539", "reactome": "R-DDI-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724527", "species_113592" ], "products": [ "species_29370", "species_10724536" ], "modifiers": [ [ "species_10724527", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10678590": { "compartment": "compartment_876", "id": "reaction_10678590", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678586", "species_10678454" ], "products": [ "species_10678588" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54VD5", "DDB_G0280437", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "species_29438", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724534": { "compartment": "compartment_74700", "id": "reaction_10724534", "reactome": "R-DDI-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10724525" ], "products": [ "species_10724527", "species_29370" ], "modifiers": [ [ "species_10724525", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "species_29426", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54HS0", "DDB_G0289277", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q54XX5", "DDB_G0278535", "Q55BW0", "DDB_G0270340" ] }, "reaction_10724561": { "compartment": "compartment_7660", "id": "reaction_10724561", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10724549" ], "products": [ "species_113582", "species_10724552" ], "modifiers": [ [ "species_10724558", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10724023": { "compartment": "compartment_70101", "id": "reaction_10724023", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9026307" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10724019": { "compartment": "compartment_70101", "id": "reaction_10724019", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026293" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724021": { "compartment": "compartment_70101", "id": "reaction_10724021", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10692055": { "compartment": "compartment_70101", "id": "reaction_10692055", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680794", "species_1497857" ], "products": [ "species_29870", "species_10692053" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680817": { "compartment": "compartment_70101", "id": "reaction_10680817", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680768", "species_10680089" ], "products": [ "species_10680776" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680970": { "compartment": "compartment_20699", "id": "reaction_10680970", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680934" ], "products": [ "species_10680751" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680960": { "compartment": "compartment_876", "id": "reaction_10680960", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751" ], "products": [ "species_76168", "species_10680805" ], "modifiers": [ [ "species_10680957", "catalyst" ] ], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "Q54T49", "DDB_G0282005" ] }, "reaction_10692058": { "compartment": "compartment_70101", "id": "reaction_10692058", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_29366", "species_1222424" ], "modifiers": [ [ "species_10692053", "catalyst" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "species_1497857", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680792": { "compartment": "compartment_70101", "id": "reaction_10680792", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680776" ], "products": [ "species_29370", "species_10680790" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "species_29426", "O00897", "DDB_G0269104", "P54644", "DDB_G0268620", "species_74016", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10692064": { "compartment": "compartment_70101", "id": "reaction_10692064", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_1497811" ], "products": [ "species_29366", "species_1497857" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10680815": { "compartment": "compartment_20699", "id": "reaction_10680815", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680805" ], "products": [ "species_10680813" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10680942": { "compartment": "compartment_20699", "id": "reaction_10680942", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680803", "species_200993" ], "products": [ "species_10680934" ], "modifiers": [ [ "species_10680939", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "DDB_G0278239" ] }, "reaction_10692051": { "compartment": "compartment_70101", "id": "reaction_10692051", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10680790" ], "products": [ "species_10680794" ], "modifiers": [], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870", "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680797": { "compartment": "compartment_70101", "id": "reaction_10680797", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10680794", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_29426", "O00897", "DDB_G0269104", "species_74016", "species_71185", "Q7Z2B8", "DDB_G0277917", "species_113596", "Q54L96", "DDB_G0286763", "P02599", "DDB_G0279407", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_76629", "Q55CT1", "DDB_G0269912", "P54651", "DDB_G0267400", "species_29870" ] }, "reaction_10680950": { "compartment": "compartment_70101", "id": "reaction_10680950", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10680948" ], "products": [ "species_10680803" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10685205": { "compartment": "compartment_70101", "id": "reaction_10685205", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429974", "species_29356" ], "products": [ "species_109395", "species_109402", "species_429926", "species_76577", "species_113578" ], "modifiers": [ [ "species_10685202", "catalyst" ] ], "additional_components": [ "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769", "Q54HV0", "DDB_G0289175", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q86K90", "DDB_G0277211", "Q54EV5", "DDB_G0291310", "Q54S59", "DDB_G0282793", "Q54VM4", "DDB_G0280251" ] }, "reaction_10690044": { "compartment": "compartment_7660", "id": "reaction_10690044", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690036", "species_10690021" ], "products": [ "species_10690042" ], "modifiers": [], "additional_components": [ "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690384": { "compartment": "compartment_7660", "id": "reaction_10690384", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690021" ], "products": [ "species_10690382" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690040": { "compartment": "compartment_7660", "id": "reaction_10690040", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690036" ], "products": [ "species_10690038" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690376": { "compartment": "compartment_7660", "id": "reaction_10690376", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_10690372" ], "products": [ "species_10690374" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q7KWP1", "DDB_G0276799", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690388": { "compartment": "compartment_7660", "id": "reaction_10690388", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10690019" ], "products": [ "species_10690386" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10690380": { "compartment": "compartment_7660", "id": "reaction_10690380", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690372", "species_10689991" ], "products": [ "species_10690378" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679987": { "compartment": "compartment_70101", "id": "reaction_10679987", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29386", "species_29356" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10679984", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10679977": { "compartment": "compartment_70101", "id": "reaction_10679977", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73524", "species_113592" ], "products": [ "species_29386", "species_111294" ], "modifiers": [ [ "species_10679974", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10701666": { "compartment": "compartment_13231", "id": "reaction_10701666", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10700336", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10699545": { "compartment": "compartment_70101", "id": "reaction_10699545", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699541", "species_10699543" ], "products": [ "species_10699415" ], "modifiers": [], "additional_components": [ "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_113592", "P36415", "DDB_G0269144", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568" ] }, "reaction_10702418": { "compartment": "compartment_70101", "id": "reaction_10702418", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699485" ], "products": [ "species_10702412" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "species_113592", "Q54DA8", "DDB_G0292404", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400" ] }, "reaction_10699420": { "compartment": "compartment_70101", "id": "reaction_10699420", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699415" ], "products": [ "species_10699417", "species_29372" ], "modifiers": [ [ "species_10699415", "catalyst" ], [ "species_10699413", "catalyst" ] ], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_113592", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10699487": { "compartment": "compartment_70101", "id": "reaction_10699487", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699417", "species_10699479", "species_10699473" ], "products": [ "species_10699413", "species_10699485" ], "modifiers": [], "additional_components": [ "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "Q54VQ1", "DDB_G0280037", "species_29370", "P36415", "DDB_G0269144", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "DDB_G0292404", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q557E0", "DDB_G0273249", "Q54BE0", "DDB_G0293678", "Q54BD8", "DDB_G0293678", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "P54651", "DDB_G0267400" ] }, "reaction_10678193": { "compartment": "compartment_5460", "id": "reaction_10678193", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678182", "species_73663" ], "products": [ "species_76633", "species_10678180" ], "modifiers": [ [ "species_10678190", "catalyst" ] ], "additional_components": [ "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10677420": { "compartment": "compartment_70616", "id": "reaction_10677420", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_76633", "species_113529", "species_73663" ], "products": [ "species_10677282", "species_76633", "species_163953", "species_73663" ], "modifiers": [ [ "species_10677417", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q54M82", "DDB_G0286171", "Q4W6B5", "DDB_G0288777", "Q86A84", "DDB_G0274809", "Q54D07", "DDB_G0292594", "Q37311", "DDB_G0294078", "Q1ZXP3", "DDB_G0271774", "Q54QR8", "DDB_G0283669", "Q54F93", "DDB_G0290997" ] }, "reaction_10709072": { "compartment": "compartment_5460", "id": "reaction_10709072", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10709068" ], "products": [ "species_10709070" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10714760": { "compartment": "compartment_5460", "id": "reaction_10714760", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714105", "species_10711174", "species_10714098", "species_10714110", "species_10711176" ], "products": [ "species_10714112" ], "modifiers": [], "additional_components": [ "Q559Z0", "DDB_G0272266", "species_113596", "Q54NI6", "DDB_G0285239", "Q54S83", "DDB_G0282615", "Q23883", "DDB_G0294030", "DDB_G0294032", "Q86K57", "DDB_G0277231", "P22237", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "species_113596" ] }, "reaction_10678185": { "compartment": "compartment_5460", "id": "reaction_10678185", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678180", "species_31649" ], "products": [ "species_113596", "species_10678182" ], "modifiers": [ [ "species_10678180", "catalyst" ] ], "additional_components": [ "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596", "species_76577", "species_31649", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_76577", "Q54YZ4", "DDB_G0277991", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10711196": { "compartment": "compartment_5460", "id": "reaction_10711196", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711190", "species_10711185", "species_10709070", "species_76629" ], "products": [ "species_10711194", "species_10711192", "species_10709068" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "Q54F10", "DDB_G0291173", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193" ] }, "reaction_10711180": { "compartment": "compartment_5460", "id": "reaction_10711180", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709070", "species_10711168" ], "products": [ "species_10711178", "species_10709068" ], "modifiers": [], "additional_components": [ "Q54F15", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q86K57", "DDB_G0277231", "DDB_G0291193" ] }, "reaction_10716369": { "compartment": "compartment_7660", "id": "reaction_10716369", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6810408" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10716366", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10714921": { "compartment": "compartment_7660", "id": "reaction_10714921", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10714909" ], "products": [ "species_113582", "species_10714919" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721110": { "compartment": "compartment_7660", "id": "reaction_10721110", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721103", "species_10687932" ], "products": [ "species_10721108" ], "modifiers": [], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0268618", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q55EZ0", "DDB_G0268618", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10721106": { "compartment": "compartment_7660", "id": "reaction_10721106", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721092", "species_29358" ], "products": [ "species_113582", "species_10721103" ], "modifiers": [ [ "species_10685946", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10716021": { "compartment": "compartment_7660", "id": "reaction_10716021", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700208", "species_6810408" ], "products": [ "species_10716019" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "species_6810408", "Q54PN9", "DDB_G0284411" ] }, "reaction_10671182": { "compartment": "compartment_5460", "id": "reaction_10671182", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379717", "species_113597" ], "products": [ "species_164934", "species_113529", "species_113590" ], "modifiers": [ [ "species_10671179", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10722466": { "compartment": "compartment_5460", "id": "reaction_10722466", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215", "species_113597" ], "products": [ "species_164934", "species_113521", "species_113590" ], "modifiers": [ [ "species_10710922", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10690088": { "compartment": "compartment_70101", "id": "reaction_10690088", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10690056": { "compartment": "compartment_70101", "id": "reaction_10690056", "reactome": "R-DDI-1237069", "name": "RHAG transports CO2 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237009" ], "products": [ "species_113528" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10702542": { "compartment": "compartment_70101", "id": "reaction_10702542", "reactome": "R-DDI-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10702540" ], "products": [ "species_10702524", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "species_29438", "Q54V41", "DDB_G0280633", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10723639": { "compartment": "compartment_70101", "id": "reaction_10723639", "reactome": "R-DDI-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723634" ], "products": [ "species_29372", "species_10723636" ], "modifiers": [ [ "species_10723261", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723645": { "compartment": "compartment_70101", "id": "reaction_10723645", "reactome": "R-DDI-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723641", "species_10723634" ], "products": [ "species_10723643" ], "modifiers": [], "additional_components": [ "Q54ND2", "DDB_G0285391", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q55GN5", "DDB_G0267590", "Q54XT6", "DDB_G0278755", "O00899", "DDB_G0269140", "Q54FF4", "DDB_G0290891", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "Q1ZXA8", "DDB_G0292160", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q1ZXJ6", "DDB_G0278011", "Q55GN5", "DDB_G0267590", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q9GPS0", "DDB_G0269178", "Q8SSN9", "DDB_G0274243", "P34145", "DDB_G0268622", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54QF1", "DDB_G0283983", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54J98", "DDB_G0288205", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "P34146", "DDB_G0282365", "Q55DD4", "DDB_G0269696", "Q7YXU4", "DDB_G0293008", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54K65", "DDB_G0290995", "Q54XT6", "DDB_G0278755", "species_29438", "O00899", "DDB_G0269140", "Q9GPR7", "DDB_G0269240", "Q54FF4", "DDB_G0290891", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q869N2", "DDB_G0276459" ] }, "reaction_10723650": { "compartment": "compartment_876", "id": "reaction_10723650", "reactome": "R-DDI-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723636" ], "products": [ "species_29420", "species_10723634" ], "modifiers": [ [ "species_10723647", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54PK2", "DDB_G0291085", "Q54F64", "DDB_G0291085", "Q54J11", "DDB_G0288383", "Q54MM3", "DDB_G0285859", "Q54B37", "DDB_G0293978", "Q54KI4", "DDB_G0287325", "Q1ZXN6", "DDB_G0272372" ] }, "reaction_10723940": { "compartment": "compartment_876", "id": "reaction_10723940", "reactome": "R-DDI-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723634" ], "products": [ "species_10723938" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10705788": { "compartment": "compartment_7660", "id": "reaction_10705788", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705770", "species_10705784" ], "products": [ "species_10705786" ], "modifiers": [], "additional_components": [ "Q557E6", "DDB_G0273139", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q1ZXF0", "DDB_G0285287", "Q557E6", "DDB_G0273139", "Q54ED2", "DDB_G0291570", "Q54G98", "DDB_G0290297", "Q54PJ7", "DDB_G0284507", "Q54DM3", "DDB_G0292130", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q8T2T7", "DDB_G0275257", "Q1ZXF0", "DDB_G0285287", "Q86IV6", "DDB_G0274777" ] }, "reaction_10705715": { "compartment": "compartment_7660", "id": "reaction_10705715", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705710" ], "products": [ "species_113582", "species_10705713" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10705801": { "compartment": "compartment_7660", "id": "reaction_10705801", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705796" ], "products": [ "species_30555", "species_10705798" ], "modifiers": [ [ "species_10705796", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q54ED2", "DDB_G0291570", "Q54GC4", "DDB_G0290275", "Q553E9", "DDB_G0275845", "Q54LI7", "DDB_G0286621", "Q54DM3", "DDB_G0292130", "Q8T2T7", "DDB_G0275257", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54BN2", "DDB_G0293546" ] }, "reaction_10674992": { "compartment": "compartment_7660", "id": "reaction_10674992", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988" ], "products": [ "species_10674990" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10710990": { "compartment": "compartment_7660", "id": "reaction_10710990", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710986", "species_10710981" ], "products": [ "species_10710988" ], "modifiers": [], "additional_components": [ "DDB_G0293476", "DDB_G0268216", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10722017": { "compartment": "compartment_70101", "id": "reaction_10722017", "reactome": "R-DDI-8951648", "name": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722004", "species_113592", "species_10709503" ], "products": [ "species_10722014", "species_111294", "species_76577" ], "modifiers": [ [ "species_10722004", "catalyst" ] ], "additional_components": [ "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722037": { "compartment": "compartment_70101", "id": "reaction_10722037", "reactome": "R-DDI-8951661", "name": "Transfer of NEDD8 to AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722026" ], "products": [ "species_10722034", "species_10722014" ], "modifiers": [ [ "species_10722026", "catalyst" ] ], "additional_components": [ "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722288": { "compartment": "compartment_7660", "id": "reaction_10722288", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722257", "species_10722191", "species_10722245" ], "products": [ "species_10722259" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10709510": { "compartment": "compartment_70101", "id": "reaction_10709510", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709501", "species_29356" ], "products": [ "species_10709507", "species_10709505" ], "modifiers": [ [ "species_10709501", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10722444": { "compartment": "compartment_70101", "id": "reaction_10722444", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10722440" ], "products": [ "species_10722442" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436" ] }, "reaction_10722556": { "compartment": "compartment_7660", "id": "reaction_10722556", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722283" ], "products": [ "species_10722553", "species_10722551" ], "modifiers": [ [ "species_10709642", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q550I8", "DDB_G0277089", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0278711", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10722452": { "compartment": "compartment_7660", "id": "reaction_10722452", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722448", "species_10722243" ], "products": [ "species_10722245", "species_10722446" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54QW6", "DDB_G0283565", "DDB_G0274167" ] }, "reaction_10722571": { "compartment": "compartment_70101", "id": "reaction_10722571", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722567", "species_10722562" ], "products": [ "species_10722569" ], "modifiers": [], "additional_components": [ "DDB_G0270358", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54XF7", "DDB_G0278991", "Q54DR0", "DDB_G0292074", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "B0G147", "DDB_G0284369", "Q54K33", "DDB_G0287629", "Q55BU7", "DDB_G0270358", "Q54P14", "DDB_G0284879", "O60999", "DDB_G0291972", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54Q05", "DDB_G0284201" ] }, "reaction_10722039": { "compartment": "compartment_70101", "id": "reaction_10722039", "reactome": "R-DDI-8951751", "name": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722024", "species_10722019" ], "products": [ "species_10722026" ], "modifiers": [], "additional_components": [ "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722021": { "compartment": "compartment_70101", "id": "reaction_10722021", "reactome": "R-DDI-8951656", "name": "NEDD8-UBA3:NAE1 binds a second NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10722014", "species_10709503" ], "products": [ "species_111294", "species_76577", "species_10722019" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965", "DDB_G0278711", "Q54XV3", "DDB_G0278711", "Q54QG9", "DDB_G0283891", "Q54JM3", "DDB_G0287965" ] }, "reaction_10722450": { "compartment": "compartment_7660", "id": "reaction_10722450", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722219", "species_10722446" ], "products": [ "species_10722448" ], "modifiers": [], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565", "DDB_G0274167", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q55DE3", "DDB_G0269686", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q86KD1", "DDB_G0274167", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q552R1", "DDB_G0275925", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QW6", "DDB_G0283565" ] }, "reaction_10722460": { "compartment": "compartment_70101", "id": "reaction_10722460", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722118", "species_10722442" ], "products": [ "species_10722458", "species_10709665" ], "modifiers": [], "additional_components": [ "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54P14", "DDB_G0284879", "Q54DR0", "DDB_G0292074", "Q86IW8", "DDB_G0274791", "Q54CU8", "DDB_G0292688", "Q54MP2", "DDB_G0285813", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q86KD1", "DDB_G0274167", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0274167" ] }, "reaction_10722577": { "compartment": "compartment_876", "id": "reaction_10722577", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722160", "species_10722178" ], "products": [ "species_10722180" ], "modifiers": [], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "DDB_G0290025", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722182": { "compartment": "compartment_70101", "id": "reaction_10722182", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722162" ], "products": [ "species_10722174", "species_10722024" ], "modifiers": [ [ "species_10722162", "catalyst" ], [ "species_10722180", "inhibitor" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005" ] }, "reaction_10722185": { "compartment": "compartment_70101", "id": "reaction_10722185", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722143", "species_10722034", "species_10722160" ], "products": [ "species_10722162" ], "modifiers": [], "additional_components": [ "Q86JM4", "DDB_G0272016", "Q54GP1", "DDB_G0290025", "B0G147", "DDB_G0284369", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54UQ3", "DDB_G0280895", "Q554G3", "DDB_G0275249", "Q550I8", "DDB_G0277089", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q54CU8", "DDB_G0292688", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q1ZXI1", "DDB_G0279085", "Q86IW8", "DDB_G0274791", "Q54MP2", "DDB_G0285813", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795", "Q54RP0", "DDB_G0283005", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54TI6", "DDB_G0281725", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54RP0", "DDB_G0283005", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54F90", "DDB_G0291003", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722286": { "compartment": "compartment_7660", "id": "reaction_10722286", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722259" ], "products": [ "species_10722283", "species_10722261" ], "modifiers": [ [ "species_10722259", "catalyst" ] ], "additional_components": [ "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q55DE3", "DDB_G0269686", "B0G147", "DDB_G0284369", "Q54CS2", "DDB_G0292794", "Q54IY4", "DDB_G0288453", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795", "DDB_G0281725", "Q54MK9", "DDB_G0285955", "Q550I8", "DDB_G0277089", "Q7KWL3", "DDB_G0276815", "Q54TI6", "DDB_G0281725", "Q54MH6", "DDB_G0285847", "Q54CU8", "DDB_G0292688", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54SD4", "DDB_G0282529", "Q54E28", "DDB_G0291832", "Q552R1", "DDB_G0275925", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54QW6", "DDB_G0283565", "Q554G3", "DDB_G0275249", "Q86JM4", "DDB_G0272016", "Q86I14", "DDB_G0275055", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "B0G147", "DDB_G0284369", "Q55DE3", "DDB_G0269686", "Q54IY4", "DDB_G0288453", "Q54CS2", "DDB_G0292794", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q551N8", "DDB_G0276481", "Q54KL5", "DDB_G0287273", "Q54QK4", "DDB_G0283795" ] }, "reaction_10722549": { "compartment": "compartment_70101", "id": "reaction_10722549", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722536" ], "products": [ "species_10722546", "species_10709503" ], "modifiers": [ [ "species_10718564", "catalyst" ] ], "additional_components": [ "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q54DR0", "DDB_G0292074", "Q8T2F2", "DDB_G0277439", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q550I8", "DDB_G0277089", "Q54XF7", "DDB_G0278991", "Q86JC1", "DDB_G0272666", "Q54CU8", "DDB_G0292688", "Q9XZJ3", "DDB_G0267384", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54GP1", "DDB_G0290025", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "Q54RP0", "DDB_G0283005", "Q55C56", "DDB_G0272666", "Q554G3", "DDB_G0275249", "Q86I14", "DDB_G0275055", "Q86JM4", "DDB_G0272016", "Q54MA5", "DDB_G0286077", "Q8T2F2", "DDB_G0277439", "Q54DR0", "DDB_G0292074", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "B0G147", "DDB_G0284369", "Q54N86", "DDB_G0285445", "Q54DF3", "DDB_G0292302", "Q86J11", "DDB_G0274267", "Q54XA6", "DDB_G0279093", "Q557E4", "DDB_G0273251", "Q54DL2", "DDB_G0292144", "P52285", "DDB_G0269230", "Q54P14", "DDB_G0284879", "Q86IW8", "DDB_G0274791", "Q54NZ5", "DDB_G0284903", "Q54F90", "DDB_G0291003", "Q54X83", "DDB_G0279139", "Q54QK4", "DDB_G0283795", "Q86K42", "DDB_G0277249", "Q54D84", "DDB_G0292436", "DDB_G0278711", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10721997": { "compartment": "compartment_70101", "id": "reaction_10721997", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709505" ], "products": [ "species_10709192", "species_10709503" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0282007", "DDB_G0278711" ] }, "reaction_10678743": { "compartment": "compartment_70101", "id": "reaction_10678743", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670505", "species_10670510" ], "products": [ "species_10670512" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678860": { "compartment": "compartment_70101", "id": "reaction_10678860", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678797" ], "products": [ "species_10676841", "species_10670505" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0285601", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10680376": { "compartment": "compartment_7660", "id": "reaction_10680376", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10680349" ], "products": [ "species_113582", "species_10680353" ], "modifiers": [ [ "species_10680373", "catalyst" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10699967": { "compartment": "compartment_7660", "id": "reaction_10699967", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699958", "species_10669917" ], "products": [ "species_10699964" ], "modifiers": [ [ "species_10699958", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699948": { "compartment": "compartment_7660", "id": "reaction_10699948", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10699950": { "compartment": "compartment_7660", "id": "reaction_10699950", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10691859": { "compartment": "compartment_12045", "id": "reaction_10691859", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_109395", "species_1500581" ], "modifiers": [ [ "species_10691856", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10692020": { "compartment": "compartment_12045", "id": "reaction_10692020", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10692017", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10692009": { "compartment": "compartment_12045", "id": "reaction_10692009", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_428686" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10692006", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10692047": { "compartment": "compartment_70101", "id": "reaction_10692047", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10692044", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10676812": { "compartment": "compartment_70101", "id": "reaction_10676812", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29356", "species_209914" ], "products": [ "species_29408", "species_29382", "species_500604" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683049": { "compartment": "compartment_5460", "id": "reaction_10683049", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380598", "species_113526" ], "products": [ "species_380593", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10676257": { "compartment": "compartment_70101", "id": "reaction_10676257", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676252" ], "products": [ "species_10676252" ], "modifiers": [ [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q23917", "DDB_G0284331", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10676146": { "compartment": "compartment_70101", "id": "reaction_10676146", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10676255": { "compartment": "compartment_70101", "id": "reaction_10676255", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676252", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331" ] }, "reaction_10676273": { "compartment": "compartment_70101", "id": "reaction_10676273", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676143", "species_29356" ], "products": [ "species_10676101", "species_29372", "species_10676271" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "DDB_G0292736", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10676198": { "compartment": "compartment_7660", "id": "reaction_10676198", "reactome": "R-DDI-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676189" ], "products": [ "species_113582", "species_10676195" ], "modifiers": [ [ "species_10676189", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54W86", "DDB_G0279831" ] }, "reaction_10676157": { "compartment": "compartment_70101", "id": "reaction_10676157", "reactome": "R-DDI-111881", "name": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_74016", "species_10676153" ], "products": [ "species_10676155" ], "modifiers": [], "additional_components": [ "DDB_G0292858", "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676160": { "compartment": "compartment_12045", "id": "reaction_10676160", "reactome": "R-DDI-111883", "name": "Hydrolysis of phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10676155", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858", "species_426925" ] }, "reaction_10676234": { "compartment": "compartment_876", "id": "reaction_10676234", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10676221", "catalyst" ], [ "species_10676232", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10685523": { "compartment": "compartment_70101", "id": "reaction_10685523", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10685515" ], "products": [ "species_113582", "species_10685520" ], "modifiers": [ [ "species_10685515", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10671131": { "compartment": "compartment_5460", "id": "reaction_10671131", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113587" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10682718": { "compartment": "compartment_70101", "id": "reaction_10682718", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10682713", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10671817": { "compartment": "compartment_70101", "id": "reaction_10671817", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10671014": { "compartment": "compartment_70101", "id": "reaction_10671014", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_29800" ], "products": [ "species_29578", "species_29360", "species_29372" ], "modifiers": [ [ "species_10670947", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10682769": { "compartment": "compartment_5460", "id": "reaction_10682769", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_29376", "species_113525" ], "modifiers": [ [ "species_10682766", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10682774": { "compartment": "compartment_70101", "id": "reaction_10682774", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10670994": { "compartment": "compartment_70101", "id": "reaction_10670994", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670989", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10671814": { "compartment": "compartment_70101", "id": "reaction_10671814", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10671811", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10671030": { "compartment": "compartment_70101", "id": "reaction_10671030", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10671027", "catalyst" ] ], "additional_components": [ "Q9GPM4", "DDB_G0287595", "species_29926" ] }, "reaction_10680112": { "compartment": "compartment_70101", "id": "reaction_10680112", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10682918": { "compartment": "compartment_70101", "id": "reaction_10682918", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10680109", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10671010": { "compartment": "compartment_70101", "id": "reaction_10671010", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10671007", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10670833": { "compartment": "compartment_70101", "id": "reaction_10670833", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_113528", "species_29492", "species_29420" ], "modifiers": [ [ "species_10670830", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10680122": { "compartment": "compartment_70101", "id": "reaction_10680122", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_198498" ], "products": [ "species_70106", "species_73473", "species_76213" ], "modifiers": [ [ "species_10680119", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10671057": { "compartment": "compartment_70101", "id": "reaction_10671057", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29492", "species_29356" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10671054", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "species_29926", "Q55F83", "DDB_G0268214" ] }, "reaction_10671012": { "compartment": "compartment_70101", "id": "reaction_10671012", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10670957", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10698893": { "compartment": "compartment_70101", "id": "reaction_10698893", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698875" ], "products": [ "species_10698877" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698891": { "compartment": "compartment_70101", "id": "reaction_10698891", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698877" ], "products": [ "species_10698889" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10698905": { "compartment": "compartment_70101", "id": "reaction_10698905", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10698903" ], "products": [ "species_10698875", "species_29370" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10690190": { "compartment": "compartment_876", "id": "reaction_10690190", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690187", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10691628": { "compartment": "compartment_12045", "id": "reaction_10691628", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691786": { "compartment": "compartment_12045", "id": "reaction_10691786", "reactome": "R-DDI-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691783": { "compartment": "compartment_12045", "id": "reaction_10691783", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691780", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691768": { "compartment": "compartment_12045", "id": "reaction_10691768", "reactome": "R-DDI-1482827", "name": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_975614", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691760": { "compartment": "compartment_12045", "id": "reaction_10691760", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10691757", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858", "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691643": { "compartment": "compartment_12045", "id": "reaction_10691643", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_76194", "species_426925" ], "modifiers": [ [ "species_10691625", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10720446": { "compartment": "compartment_12045", "id": "reaction_10720446", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10720443", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36314", "CHEBI:36313", "DDB_G0275665" ] }, "reaction_10676046": { "compartment": "compartment_7660", "id": "reaction_10676046", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676042" ], "products": [ "species_10676044", "species_10675681" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10676048": { "compartment": "compartment_7660", "id": "reaction_10676048", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675681" ], "products": [ "species_10676042" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10725757": { "compartment": "compartment_7660", "id": "reaction_10725757", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725753", "species_10677256" ], "products": [ "species_10725755" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10697242": { "compartment": "compartment_7660", "id": "reaction_10697242", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697226", "species_29358" ], "products": [ "species_113582", "species_10697239" ], "modifiers": [ [ "species_10697226", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10696648": { "compartment": "compartment_7660", "id": "reaction_10696648", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696641", "species_113685" ], "products": [ "species_10696645", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10696641", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "species_71067", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10696618": { "compartment": "compartment_7660", "id": "reaction_10696618", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696614", "species_10670680" ], "products": [ "species_10696616" ], "modifiers": [], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "DDB_G0290551", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697218": { "compartment": "compartment_7660", "id": "reaction_10697218", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696635", "species_10696614" ], "products": [ "species_10697216" ], "modifiers": [ [ "species_10696616", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54ID6", "DDB_G0288819" ] }, "reaction_10697246": { "compartment": "compartment_7660", "id": "reaction_10697246", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676882", "species_10697244" ], "products": [ "species_10697226" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54PK4", "DDB_G0284499", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54ID6", "DDB_G0288819", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54LV0", "DDB_G0286403", "Q54DZ9", "DDB_G0291894", "Q54XY3", "DDB_G0278701", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10688018": { "compartment": "compartment_70101", "id": "reaction_10688018", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10684031", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10682708": { "compartment": "compartment_70101", "id": "reaction_10682708", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682593" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10682705", "catalyst" ] ], "additional_components": [ "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "species_74016", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10695705": { "compartment": "compartment_17957", "id": "reaction_10695705", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046048" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695686": { "compartment": "compartment_12045", "id": "reaction_10695686", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_162743", "species_113519", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695701": { "compartment": "compartment_12045", "id": "reaction_10695701", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_2046055", "species_5228339", "species_211606" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10695703": { "compartment": "compartment_17957", "id": "reaction_10695703", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_162743", "species_2046045", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10695707": { "compartment": "compartment_12045", "id": "reaction_10695707", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_2046044", "species_211579" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10695771": { "compartment": "compartment_161320", "id": "reaction_10695771", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_2065212", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10693345": { "compartment": "compartment_17938", "id": "reaction_10693345", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_76194", "species_2090069" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10693855": { "compartment": "compartment_20699", "id": "reaction_10693855", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742361", "species_10693824" ], "products": [ "species_205687", "species_10693831" ], "modifiers": [ [ "species_10693852", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269900", "Q55DR5", "DDB_G0269900", "Q55CU3", "DDB_G0269900" ] }, "reaction_10693373": { "compartment": "compartment_161320", "id": "reaction_10693373", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10693370", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10695363": { "compartment": "compartment_20699", "id": "reaction_10695363", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695342", "species_741440" ], "products": [ "species_10695349", "species_742343" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695757": { "compartment": "compartment_20699", "id": "reaction_10695757", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695744", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695773": { "compartment": "compartment_161320", "id": "reaction_10695773", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_2090063", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10693365": { "compartment": "compartment_161320", "id": "reaction_10693365", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090033" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10695445": { "compartment": "compartment_17963", "id": "reaction_10695445", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695411" ], "products": [ "species_10695443" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695373": { "compartment": "compartment_20699", "id": "reaction_10695373", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695370", "species_2022884" ], "products": [ "species_10695342", "species_2022890" ], "modifiers": [ [ "species_10695354", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695775": { "compartment": "compartment_17938", "id": "reaction_10695775", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090045", "species_76183" ], "products": [ "species_76194", "species_2090053" ], "modifiers": [ [ "species_10693342", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10695742": { "compartment": "compartment_17963", "id": "reaction_10695742", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695389", "species_741440" ], "products": [ "species_742343", "species_10695396" ], "modifiers": [ [ "species_10695737", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10695375": { "compartment": "compartment_876", "id": "reaction_10695375", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693351" ], "products": [ "species_10692697" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10695769": { "compartment": "compartment_161320", "id": "reaction_10695769", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090055", "species_1605715" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10686016": { "compartment": "compartment_70101", "id": "reaction_10686016", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10686011", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10716925": { "compartment": "compartment_20699", "id": "reaction_10716925", "reactome": "R-DDI-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10684974", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10716046": { "compartment": "compartment_20699", "id": "reaction_10716046", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715737", "species_10715128" ], "products": [ "species_10716031" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716035": { "compartment": "compartment_20699", "id": "reaction_10716035", "reactome": "R-DDI-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716031", "species_10715194" ], "products": [ "species_10716033" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716071": { "compartment": "compartment_20699", "id": "reaction_10716071", "reactome": "R-DDI-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716056" ], "products": [ "species_10715128", "species_10715276", "species_10715194", "species_10716068" ], "modifiers": [ [ "species_10716056", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10717044": { "compartment": "compartment_12045", "id": "reaction_10717044", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717040", "species_10717028" ], "products": [ "species_10717042" ], "modifiers": [], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716044": { "compartment": "compartment_20699", "id": "reaction_10716044", "reactome": "R-DDI-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716033" ], "products": [ "species_10716037", "species_29420" ], "modifiers": [ [ "species_10716033", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10716093": { "compartment": "compartment_12045", "id": "reaction_10716093", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716090", "species_113592" ], "products": [ "species_10716076", "species_10716081", "species_10681096", "species_10710119", "species_10716086", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10716090", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111", "DDB_G0267646", "DDB_G0281429", "DDB_G0269942", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716214": { "compartment": "compartment_12045", "id": "reaction_10716214", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716212", "species_10710119", "species_10710110" ], "products": [ "species_10716090" ], "modifiers": [], "additional_components": [ "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54TZ2", "DDB_G0281429", "Q54NP6", "DDB_G0285111" ] }, "reaction_10716058": { "compartment": "compartment_20699", "id": "reaction_10716058", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715775", "species_10715276", "species_10716054", "species_10716039", "species_10716048" ], "products": [ "species_10716056" ], "modifiers": [], "additional_components": [ "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "DDB_G0269942", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q769F7", "DDB_G0278969", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q556J9", "DDB_G0272889", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716041": { "compartment": "compartment_20699", "id": "reaction_10716041", "reactome": "R-DDI-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716037", "species_10715256" ], "products": [ "species_10716039" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "species_29438", "Q54EW9", "DDB_G0291293", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716957": { "compartment": "compartment_20699", "id": "reaction_10716957", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848483", "species_548819" ], "products": [ "species_76194", "species_429785" ], "modifiers": [ [ "species_10716954", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10717053": { "compartment": "compartment_12045", "id": "reaction_10717053", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10717042" ], "products": [ "species_10717050", "species_29420" ], "modifiers": [ [ "species_10717042", "catalyst" ] ], "additional_components": [ "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "species_29438", "Q54DM6", "DDB_G0292124", "species_29420", "Q54GY8", "DDB_G0289827", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10716216": { "compartment": "compartment_12045", "id": "reaction_10716216", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716210" ], "products": [ "species_10716168", "species_10716208", "species_10716212", "species_10715256", "species_10710015" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q55GJ4", "DDB_G0267646", "Q54LH0", "DDB_G0286811", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "Q55CJ0", "DDB_G0270040", "Q769F7", "DDB_G0278969", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54TZ2", "DDB_G0281429", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q55CR0", "DDB_G0269942", "Q54YZ1", "DDB_G0277997", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q55CA1", "DDB_G0270150", "Q23924", "DDB_G0284735", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F7", "DDB_G0278969", "Q769F6", "DDB_G0277923", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q55GJ4", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54LH0", "DDB_G0286811", "Q54TZ2", "DDB_G0281429", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10682380": { "compartment": "compartment_70101", "id": "reaction_10682380", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10682377", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10684029": { "compartment": "compartment_17940", "id": "reaction_10684029", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684027" ], "products": [ "species_10684027" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10709972": { "compartment": "compartment_5460", "id": "reaction_10709972", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_159549" ], "products": [ "species_10709961", "species_29376" ], "modifiers": [ [ "species_10709969", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:14949", "Q54JV8", "DDB_G0287773", "Q54KM7", "DDB_G0287255" ] }, "reaction_10709982": { "compartment": "compartment_5460", "id": "reaction_10709982", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709961", "species_200671" ], "products": [ "species_5693984", "species_10709974", "species_5693978" ], "modifiers": [ [ "species_10709979", "catalyst" ] ], "additional_components": [ "CHEBI:14949", "Q54JV8", "DDB_G0287773", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10709987": { "compartment": "compartment_5460", "id": "reaction_10709987", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709974", "species_113526" ], "products": [ "species_10709957", "species_29362", "species_113529" ], "modifiers": [ [ "species_10709984", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10684177": { "compartment": "compartment_70101", "id": "reaction_10684177", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29468", "species_29368" ], "products": [ "species_29366", "species_202124", "species_29968" ], "modifiers": [ [ "species_10684174", "catalyst" ] ], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763" ] }, "reaction_10684192": { "compartment": "compartment_70101", "id": "reaction_10684192", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10684189", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10716937": { "compartment": "compartment_12045", "id": "reaction_10716937", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30209", "species_200993" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683793": { "compartment": "compartment_17951", "id": "reaction_10683793", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10716935": { "compartment": "compartment_12045", "id": "reaction_10716935", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_76194", "species_8848499" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10710365": { "compartment": "compartment_12045", "id": "reaction_10710365", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696426", "species_192172" ], "products": [ "species_162743", "species_5696412" ], "modifiers": [ [ "species_10710362", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10683791": { "compartment": "compartment_17951", "id": "reaction_10683791", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_76194", "species_29366", "species_8848577" ], "modifiers": [ [ "species_10683788", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10681884": { "compartment": "compartment_70101", "id": "reaction_10681884", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209793", "species_71284" ], "products": [ "species_70106", "species_71285", "species_209934" ], "modifiers": [ [ "species_10681881", "catalyst" ] ], "additional_components": [ "DDB_G0289329" ] }, "reaction_10681900": { "compartment": "compartment_70101", "id": "reaction_10681900", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29500" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10681897", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10703615": { "compartment": "compartment_17938", "id": "reaction_10703615", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703600", "species_113592" ], "products": [ "species_29370", "species_10703612" ], "modifiers": [ [ "species_10703600", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725704": { "compartment": "compartment_17947", "id": "reaction_10725704", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725700" ], "products": [ "species_10725702" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704870": { "compartment": "compartment_70101", "id": "reaction_10704870", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704868" ], "products": [ "species_10704836" ], "modifiers": [], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10724968": { "compartment": "compartment_70101", "id": "reaction_10724968", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724940" ], "products": [ "species_10724966" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10722608": { "compartment": "compartment_70101", "id": "reaction_10722608", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722600", "species_10721824" ], "products": [ "species_10722602" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0277699", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699" ] }, "reaction_10704860": { "compartment": "compartment_70101", "id": "reaction_10704860", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10704857", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721818": { "compartment": "compartment_17906", "id": "reaction_10721818", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703459" ], "products": [ "species_10721816" ], "modifiers": [], "additional_components": [ "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10722606": { "compartment": "compartment_21994", "id": "reaction_10722606", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722602", "species_10701260" ], "products": [ "species_10722604" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q75K07", "DDB_G0277699" ] }, "reaction_10721827": { "compartment": "compartment_17906", "id": "reaction_10721827", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_29370", "species_10721824" ], "modifiers": [ [ "species_10721816", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337" ] }, "reaction_10703635": { "compartment": "compartment_17938", "id": "reaction_10703635", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10724956": { "compartment": "compartment_70101", "id": "reaction_10724956", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724954" ], "products": [ "species_10724952", "species_10724944" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725708": { "compartment": "compartment_70101", "id": "reaction_10725708", "reactome": "R-DDI-9664883", "name": "ATM:PEX5 translocates from cytosol to peroxisomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725652" ], "products": [ "species_10725677" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10725712": { "compartment": "compartment_70101", "id": "reaction_10725712", "reactome": "R-DDI-9664892", "name": "SQSTM1 binds ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725659", "species_10725669" ], "products": [ "species_10725671" ], "modifiers": [], "additional_components": [ "DDB_G0270098", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10724932": { "compartment": "compartment_70101", "id": "reaction_10724932", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689017", "species_10724928" ], "products": [ "species_10724930" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704855": { "compartment": "compartment_70101", "id": "reaction_10704855", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704836" ], "products": [ "species_29370", "species_10703627" ], "modifiers": [ [ "species_10704852", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10703630": { "compartment": "compartment_12045", "id": "reaction_10703630", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_5676030", "species_29370" ], "modifiers": [ [ "species_10703627", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021" ] }, "reaction_10704806": { "compartment": "compartment_70101", "id": "reaction_10704806", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704781", "species_5681998" ], "products": [ "species_10704783", "species_10704785" ], "modifiers": [ [ "species_10704803", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "DDB_G0277319", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10725698": { "compartment": "compartment_17947", "id": "reaction_10725698", "reactome": "R-DDI-9664879", "name": "ATM:PEX5 binds ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725661", "species_10725677" ], "products": [ "species_10725679" ], "modifiers": [ [ "species_1250243", "catalyst" ] ], "additional_components": [ "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703598": { "compartment": "compartment_70101", "id": "reaction_10703598", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703495" ], "products": [ "species_29370", "species_10703595" ], "modifiers": [ [ "species_10703495", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704672": { "compartment": "compartment_74700", "id": "reaction_10704672", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704214" ], "products": [ "species_10677585", "species_10703610" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10703639": { "compartment": "compartment_70101", "id": "reaction_10703639", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_10703473" ], "products": [ "species_10703600" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10725696": { "compartment": "compartment_17947", "id": "reaction_10725696", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725692" ], "products": [ "species_10725694" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0284133", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q86CR8", "DDB_G0286191" ] }, "reaction_10721810": { "compartment": "compartment_70101", "id": "reaction_10721810", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721805", "species_113592" ], "products": [ "species_10721808", "species_29370" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10704947": { "compartment": "compartment_70101", "id": "reaction_10704947", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704916" ], "products": [ "species_10704773" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10725687": { "compartment": "compartment_17947", "id": "reaction_10725687", "reactome": "R-DDI-9664862", "name": "ATM dimer:PEX5 phosphorylates PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725679" ], "products": [ "species_10725685" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705356": { "compartment": "compartment_70101", "id": "reaction_10705356", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703610" ], "products": [ "species_10703473", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337" ] }, "reaction_10704862": { "compartment": "compartment_70101", "id": "reaction_10704862", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704681" ], "products": [ "species_10704852" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10723993": { "compartment": "compartment_70101", "id": "reaction_10723993", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704874" ], "products": [ "species_10705267" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10724970": { "compartment": "compartment_70101", "id": "reaction_10724970", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724966" ], "products": [ "species_10724954" ], "modifiers": [], "additional_components": [ "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q86K32", "DDB_G0277267", "Q54IY3", "DDB_G0288427", "Q54D06", "DDB_G0292596", "Q54X77", "DDB_G0279151", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10704216": { "compartment": "compartment_70101", "id": "reaction_10704216", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703612" ], "products": [ "species_29370", "species_10704214" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q55BY0", "DDB_G0269162", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10704876": { "compartment": "compartment_70101", "id": "reaction_10704876", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704792" ], "products": [ "species_10704874" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10705132": { "compartment": "compartment_70101", "id": "reaction_10705132", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10704773", "species_5681998" ], "modifiers": [ [ "species_10704944", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q557H7", "DDB_G0273443", "Q54QM7", "DDB_G0283753" ] }, "reaction_10704949": { "compartment": "compartment_70101", "id": "reaction_10704949", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704872", "species_10704773" ], "products": [ "species_10704883" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191" ] }, "reaction_10725706": { "compartment": "compartment_17947", "id": "reaction_10725706", "reactome": "R-DDI-9664881", "name": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725671", "species_10725692" ], "products": [ "species_10725700" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "DDB_G0284133", "Q54Q21", "DDB_G0284133", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098" ] }, "reaction_10704704": { "compartment": "compartment_70101", "id": "reaction_10704704", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704700", "species_5693050" ], "products": [ "species_10704702" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54SA0", "DDB_G0282581", "Q54NA2", "DDB_G0285375", "species_1806159", "Q54SA0", "DDB_G0282581" ] }, "reaction_10705183": { "compartment": "compartment_5683628", "id": "reaction_10705183", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704783" ], "products": [ "species_10705174" ], "modifiers": [ [ "species_10705181", "catalyst" ], [ "species_10687292", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "P54676", "DDB_G0289601", "Q54JC5", "DDB_G0288175", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087" ] }, "reaction_10704864": { "compartment": "compartment_70101", "id": "reaction_10704864", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704801", "species_10704799" ], "products": [ "species_10704803" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10705335": { "compartment": "compartment_70101", "id": "reaction_10705335", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704887" ], "products": [ "species_10704872", "species_10704781" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10725710": { "compartment": "compartment_17947", "id": "reaction_10725710", "reactome": "R-DDI-9664888", "name": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725685" ], "products": [ "species_10725669" ], "modifiers": [], "additional_components": [ "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10703498": { "compartment": "compartment_70101", "id": "reaction_10703498", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703475", "species_113592" ], "products": [ "species_29370", "species_10703495" ], "modifiers": [ [ "species_10703475", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10725654": { "compartment": "compartment_70101", "id": "reaction_10725654", "reactome": "R-DDI-9664850", "name": "ATM binds PEX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724145", "species_10725650" ], "products": [ "species_10725652" ], "modifiers": [], "additional_components": [ "DDB_G0286033", "DDB_G0275845", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033" ] }, "reaction_10705269": { "compartment": "compartment_70101", "id": "reaction_10705269", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704883", "species_10704785" ], "products": [ "species_10704885" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10724942": { "compartment": "compartment_70101", "id": "reaction_10724942", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724938", "species_10724930" ], "products": [ "species_10724940" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10725675": { "compartment": "compartment_17947", "id": "reaction_10725675", "reactome": "R-DDI-9664855", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704759", "species_10725671" ], "products": [ "species_10725673" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q55CE3", "DDB_G0270098", "Q54G11", "DDB_G0290491", "Q553E9", "DDB_G0275845", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q55CE3", "DDB_G0270098" ] }, "reaction_10705145": { "compartment": "compartment_12045", "id": "reaction_10705145", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703627" ], "products": [ "species_10705136" ], "modifiers": [ [ "species_10705141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "DDB_G0285323" ] }, "reaction_10703617": { "compartment": "compartment_70101", "id": "reaction_10703617", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703473", "species_10683107" ], "products": [ "species_10703475" ], "modifiers": [], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q54R95", "DDB_G0283337", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54J54", "DDB_G0288287", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10704890": { "compartment": "compartment_70101", "id": "reaction_10704890", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704885" ], "products": [ "species_10704887" ], "modifiers": [ [ "species_10704885", "catalyst" ] ], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q550A8", "DDB_G0277319" ] }, "reaction_10704684": { "compartment": "compartment_70101", "id": "reaction_10704684", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703595" ], "products": [ "species_29370", "species_10704681" ], "modifiers": [ [ "species_10703595", "catalyst" ] ], "additional_components": [ "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q54J54", "DDB_G0288287", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54R95", "DDB_G0283337" ] }, "reaction_10714394": { "compartment": "compartment_70101", "id": "reaction_10714394", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10714372" ], "products": [ "species_71285", "species_10714379" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q9BMX0", "DDB_G0288613", "species_29438", "Q7YZN9", "DDB_G0277919", "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10709680": { "compartment": "compartment_70101", "id": "reaction_10709680", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_5691517", "species_6785226" ], "modifiers": [ [ "species_10709677", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10725743": { "compartment": "compartment_70101", "id": "reaction_10725743", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683047", "species_113592", "species_29356" ], "products": [ "species_10683043", "species_29370", "species_29372" ], "modifiers": [ [ "species_10725732", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725738": { "compartment": "compartment_13231", "id": "reaction_10725738", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725728", "species_10725722" ], "products": [ "species_10725730" ], "modifiers": [], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "DDB_G0283793", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10725736": { "compartment": "compartment_70101", "id": "reaction_10725736", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687703", "species_10725732" ], "products": [ "species_10725734" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54PT2", "DDB_G0284347", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724709": { "compartment": "compartment_1598585", "id": "reaction_10724709", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681066" ], "products": [ "species_10724701", "species_29420" ], "modifiers": [ [ "species_10724706", "catalyst" ] ], "additional_components": [ "species_29420", "P33519", "DDB_G0291235", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10698508": { "compartment": "compartment_13231", "id": "reaction_10698508", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698490" ], "products": [ "species_10698305", "species_10698505" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54N16", "DDB_G0285563", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10724716": { "compartment": "compartment_70101", "id": "reaction_10724716", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724711", "species_29356" ], "products": [ "species_10681066", "species_29372", "species_9624890" ], "modifiers": [ [ "species_10698505", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "species_29420", "P33519", "DDB_G0291235", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10725740": { "compartment": "compartment_70101", "id": "reaction_10725740", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725717", "species_10725730" ], "products": [ "species_10725732" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54KQ7", "DDB_G0287165", "Q54P63", "DDB_G0284769", "Q54QK5", "DDB_G0283793", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087" ] }, "reaction_10724713": { "compartment": "compartment_70101", "id": "reaction_10724713", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10724701" ], "products": [ "species_10724711" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10670890": { "compartment": "compartment_70101", "id": "reaction_10670890", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_75970", "species_30393" ], "modifiers": [ [ "species_10670887", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10670880": { "compartment": "compartment_70101", "id": "reaction_10670880", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10670877", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10716376": { "compartment": "compartment_70101", "id": "reaction_10716376", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_6799497" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10670900": { "compartment": "compartment_70101", "id": "reaction_10670900", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_30393" ], "products": [ "species_29370", "species_29578" ], "modifiers": [ [ "species_10670897", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10702192": { "compartment": "compartment_7660", "id": "reaction_10702192", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_10702188", "species_10702174" ], "products": [ "species_10702190" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702289": { "compartment": "compartment_7660", "id": "reaction_10702289", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702167", "species_10702172" ], "products": [ "species_10702174" ], "modifiers": [], "additional_components": [ "DDB_G0287393", "DDB_G0283981", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393" ] }, "reaction_10702208": { "compartment": "compartment_7660", "id": "reaction_10702208", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702190" ], "products": [ "species_10702205" ], "modifiers": [ [ "species_10702190", "catalyst" ] ], "additional_components": [ "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10702287": { "compartment": "compartment_7660", "id": "reaction_10702287", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702184" ], "products": [ "species_10702210" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0268614", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702227": { "compartment": "compartment_7660", "id": "reaction_10702227", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702212", "species_29358" ], "products": [ "species_113582", "species_10702188" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_113592", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702285": { "compartment": "compartment_7660", "id": "reaction_10702285", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10702179", "species_10702197" ], "products": [ "species_10702199" ], "modifiers": [], "additional_components": [ "DDB_G0275809", "DDB_G0281683", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702203": { "compartment": "compartment_7660", "id": "reaction_10702203", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10702199" ], "products": [ "species_10702201" ], "modifiers": [], "additional_components": [ "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809" ] }, "reaction_10702216": { "compartment": "compartment_7660", "id": "reaction_10702216", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358610", "species_29358" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10702214": { "compartment": "compartment_7660", "id": "reaction_10702214", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702210", "species_5358514" ], "products": [ "species_10702212" ], "modifiers": [], "additional_components": [ "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "species_29370", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809" ] }, "reaction_10702225": { "compartment": "compartment_7660", "id": "reaction_10702225", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702221", "species_10702205" ], "products": [ "species_10702223" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54QA0", "DDB_G0283981", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "species_113592", "Q54KD8", "DDB_G0287393", "Q55GU9", "DDB_G0268614", "Q553L4", "DDB_G0275809", "Q54K47", "DDB_G0287607" ] }, "reaction_10675582": { "compartment": "compartment_7660", "id": "reaction_10675582", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675580", "species_10675574" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0289199", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10675587": { "compartment": "compartment_7660", "id": "reaction_10675587", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10675584" ], "products": [ "species_113582", "species_10675580" ], "modifiers": [ [ "species_10675584", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10676478": { "compartment": "compartment_7660", "id": "reaction_10676478", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675584" ], "products": [ "species_10675584" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10675602": { "compartment": "compartment_7660", "id": "reaction_10675602", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675592", "species_10675576", "species_10675598" ], "products": [ "species_10675600" ], "modifiers": [], "additional_components": [ "DDB_G0278479", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "DDB_G0287661", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675578": { "compartment": "compartment_7660", "id": "reaction_10675578", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675576" ], "products": [ "species_10675576" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014" ] }, "reaction_10670593": { "compartment": "compartment_7660", "id": "reaction_10670593", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670586" ], "products": [ "species_10670590" ], "modifiers": [ [ "species_10670584", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609" ] }, "reaction_10670597": { "compartment": "compartment_7660", "id": "reaction_10670597", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670590" ], "products": [ "species_10670595" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670617": { "compartment": "compartment_7660", "id": "reaction_10670617", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10670614", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10670609": { "compartment": "compartment_7660", "id": "reaction_10670609", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670599" ], "products": [ "species_10670601" ], "modifiers": [ [ "species_10670606", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "DDB_G0284987" ] }, "reaction_10688208": { "compartment": "compartment_20699", "id": "reaction_10688208", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688218": { "compartment": "compartment_20699", "id": "reaction_10688218", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60629", "CHEBI:60628", "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688220": { "compartment": "compartment_20699", "id": "reaction_10688220", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964740", "species_964752" ], "modifiers": [ [ "species_10688205", "catalyst" ] ], "additional_components": [ "Q55EU0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54CH4", "DDB_G0292918" ] }, "reaction_10688216": { "compartment": "compartment_20699", "id": "reaction_10688216", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964740", "species_914003" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10688213", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10686090": { "compartment": "compartment_70101", "id": "reaction_10686090", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686088" ], "products": [], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0275027", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10686077": { "compartment": "compartment_70101", "id": "reaction_10686077", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686071", "species_450444" ], "products": [ "species_10686075" ], "modifiers": [], "additional_components": [ "Q86I71", "DDB_G0275027", "Q86I71", "DDB_G0275027" ] }, "reaction_10686313": { "compartment": "compartment_876", "id": "reaction_10686313", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686265" ], "products": [ "species_10686311" ], "modifiers": [], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q55DM8", "DDB_G0269600", "Q54V78", "DDB_G0349530", "Q54PA3", "DDB_G0284679", "Q553C3", "DDB_G0275765", "Q54D77", "DDB_G0292538", "Q8T2H0", "DDB_G0272190", "Q54Q34", "DDB_G0349530", "Q54KR6", "DDB_G0287201", "Q55ET7", "DDB_G0268758" ] }, "reaction_10686448": { "compartment": "compartment_876", "id": "reaction_10686448", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686424" ], "products": [ "species_10686446" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569" ] }, "reaction_10682506": { "compartment": "compartment_161320", "id": "reaction_10682506", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682498" ], "products": [ "species_10682504" ], "modifiers": [], "additional_components": [ "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417", "Q55EI1", "DDB_G0268890", "Q54G42", "DDB_G0290417" ] }, "reaction_10686372": { "compartment": "compartment_876", "id": "reaction_10686372", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686352" ], "products": [ "species_10686370" ], "modifiers": [], "additional_components": [ "P04988", "DDB_G0290957", "species_74016", "species_29370", "CHEBI:15996", "species_111349", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436", "P04988", "DDB_G0290957", "species_74016", "species_29370", "species_29438", "species_29926", "species_209914", "Q54TR1", "DDB_G0281605", "Q54F16", "DDB_G0291191", "species_29420", "species_29372", "Q559Q3", "DDB_G0291191", "Q54QD9", "DDB_G0283921", "species_113592", "species_113541", "Q54MB6", "DDB_G0291191", "Q54D84", "DDB_G0292436" ] }, "reaction_10686484": { "compartment": "compartment_876", "id": "reaction_10686484", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686472" ], "products": [ "species_10686482" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q54RR0", "DDB_G0282977", "Q9BKJ9", "DDB_G0287035", "Q54NC1", "DDB_G0285399", "Q54XV1", "DDB_G0278567", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10686628": { "compartment": "compartment_70101", "id": "reaction_10686628", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686552" ], "products": [ "species_10686626" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54HE7", "DDB_G0289511", "Q54PW0", "DDB_G0284261", "Q54W22", "DDB_G0282287", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54QC8", "DDB_G0283937", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54ST8", "DDB_G0282287", "P24639", "DDB_G0269160", "Q553U6", "DDB_G0275023", "Q551W8", "DDB_G0282287", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q556T3", "DDB_G0273107", "O00897", "DDB_G0269104", "P54686", "DDB_G0278733", "P32255", "DDB_G0287689", "Q54JL1", "DDB_G0287981", "Q7Z2B8", "DDB_G0277917", "Q55GQ5", "DDB_G0267420", "Q54TA6", "DDB_G0281889", "Q54HF1", "DDB_G0289505", "P02599", "DDB_G0279407", "Q54JD4", "DDB_G0288133", "Q54K81", "DDB_G0287505", "Q55CU2", "DDB_G0269902", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507" ] }, "reaction_10701635": { "compartment": "compartment_70101", "id": "reaction_10701635", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701632", "species_113592" ], "products": [ "species_10679174", "species_29370", "species_10678454", "species_5218688" ], "modifiers": [ [ "species_10701626", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_428193", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0284545" ] }, "reaction_10725915": { "compartment": "compartment_70101", "id": "reaction_10725915", "reactome": "R-DDI-9701529", "name": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725899" ], "products": [ "species_10725913" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10725936": { "compartment": "compartment_7660", "id": "reaction_10725936", "reactome": "R-DDI-9701565", "name": "HDACs deacetylate p-STAT3 dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10725931" ], "products": [ "species_10725913", "species_427486" ], "modifiers": [ [ "species_10725933", "catalyst" ] ], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q55FN5", "DDB_G0268024", "Q55BW2", "DDB_G0270338" ] }, "reaction_10677104": { "compartment": "compartment_70101", "id": "reaction_10677104", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10677101", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10675817": { "compartment": "compartment_70101", "id": "reaction_10675817", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10675791" ], "products": [ "species_29370", "species_10675814" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10680170": { "compartment": "compartment_70101", "id": "reaction_10680170", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680149" ], "products": [ "species_29370", "species_10680079" ], "modifiers": [ [ "species_10680163", "catalyst" ], [ "species_10680168", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10697254": { "compartment": "compartment_876", "id": "reaction_10697254", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680079", "species_10675800" ], "products": [ "species_10680081" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10697252": { "compartment": "compartment_70101", "id": "reaction_10697252", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10725901": { "compartment": "compartment_70101", "id": "reaction_10725901", "reactome": "R-DDI-9701525", "name": "p-Y705,S727-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725897" ], "products": [ "species_10725899" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10674483": { "compartment": "compartment_17940", "id": "reaction_10674483", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10690303": { "compartment": "compartment_70101", "id": "reaction_10690303", "reactome": "R-DDI-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10690293" ], "products": [ "species_29370", "species_10690301" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "B0G199", "DDB_G0293770", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10680102": { "compartment": "compartment_70101", "id": "reaction_10680102", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680081", "species_113592" ], "products": [ "species_29370", "species_10680099", "species_10675800" ], "modifiers": [ [ "species_10680081", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10675793": { "compartment": "compartment_876", "id": "reaction_10675793", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675789" ], "products": [ "species_10675775", "species_10675791" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10714853": { "compartment": "compartment_7660", "id": "reaction_10714853", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672464", "species_10672420", "species_10714849" ], "products": [ "species_10714851" ], "modifiers": [], "additional_components": [ "DDB_G0284321", "DDB_G0280393", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54PW8", "DDB_G0284321", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54VI2", "DDB_G0280393" ] }, "reaction_10675802": { "compartment": "compartment_876", "id": "reaction_10675802", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10675798" ], "products": [ "species_10675800" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10693751": { "compartment": "compartment_70101", "id": "reaction_10693751", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_113592" ], "products": [ "species_29370", "species_1629765" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693634": { "compartment": "compartment_70101", "id": "reaction_10693634", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_29370", "species_1629732" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693551": { "compartment": "compartment_70101", "id": "reaction_10693551", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693631": { "compartment": "compartment_70101", "id": "reaction_10693631", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693543": { "compartment": "compartment_70101", "id": "reaction_10693543", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10693711": { "compartment": "compartment_70101", "id": "reaction_10693711", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_994149", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10693620": { "compartment": "compartment_70101", "id": "reaction_10693620", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10693617", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10693742": { "compartment": "compartment_70101", "id": "reaction_10693742", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10693540", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10690279": { "compartment": "compartment_876", "id": "reaction_10690279", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690276", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690258": { "compartment": "compartment_876", "id": "reaction_10690258", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690255", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690146": { "compartment": "compartment_876", "id": "reaction_10690146", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690143", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10690247": { "compartment": "compartment_876", "id": "reaction_10690247", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690244", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10690159": { "compartment": "compartment_876", "id": "reaction_10690159", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690156", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10690197": { "compartment": "compartment_876", "id": "reaction_10690197", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690194", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255" ] }, "reaction_10690226": { "compartment": "compartment_876", "id": "reaction_10690226", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10690223", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10678283": { "compartment": "compartment_876", "id": "reaction_10678283", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678272", "species_10678254" ], "products": [ "species_10678274" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10684258": { "compartment": "compartment_876", "id": "reaction_10684258", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682952", "species_352003" ], "products": [ "species_10682954" ], "modifiers": [], "additional_components": [ "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_916850", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356" ] }, "reaction_10678281": { "compartment": "compartment_876", "id": "reaction_10678281", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_10678278", "species_29372" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678307": { "compartment": "compartment_876", "id": "reaction_10678307", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678274" ], "products": [ "species_29372", "species_10678292" ], "modifiers": [ [ "species_10678274", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678294": { "compartment": "compartment_876", "id": "reaction_10678294", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678292" ], "products": [ "species_10676221", "species_10678276", "species_10678290" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_111349", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10672907": { "compartment": "compartment_7660", "id": "reaction_10672907", "reactome": "R-DDI-72130", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672894", "species_10672779", "species_10672899", "species_10672884", "species_10672879", "species_10672889", "species_10672874" ], "products": [ "species_10672755", "species_10672287", "species_10672241", "species_10672598", "species_10672340", "species_10672335", "species_10672760", "species_10672345", "species_10672905" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q54WN2", "DDB_G0279535", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54HF6", "DDB_G0289499", "Q55FQ0", "DDB_G0268004", "Q9NI62", "DDB_G0269216", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54BG2", "DDB_G0293636", "Q55EC6", "DDB_G0269300", "Q54R72", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672931", "species_10676865" ], "products": [ "species_10672949" ], "modifiers": [], "additional_components": [ "Q55E21", "DDB_G0270866", "Q54ME8", "DDB_G0286007", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54WZ0", "DDB_G0279311", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q1ZXF6", "DDB_G0284555", "Q54DH7", "DDB_G0292244", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q54PG4", "DDB_G0284573", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "Q55E21", "DDB_G0270866", "P36415", "DDB_G0269144", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q54WZ0", "DDB_G0279311", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q55AR8", "DDB_G0271788", "Q54J75", "DDB_G0288257", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q55F01", "DDB_G0269054", "Q86I71", "DDB_G0275027", "Q54NJ4", "DDB_G0285213", "Q54CT3", "DDB_G0292778", "P35084", "DDB_G0279193", "Q54WP9", "DDB_G0279507", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54ME8", "DDB_G0286007", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q86A14", "DDB_G0272676", "Q54ZS8", "DDB_G0277371", "Q55BL6", "DDB_G0270450", "Q54CN1", "DDB_G0292846", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54GS9", "DDB_G0289933", "Q54DH9", "DDB_G0292240", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q54R66", "DDB_G0283365", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "C7G084", "DDB_G0295793", "Q54PX3", "DDB_G0291966", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10672912": { "compartment": "compartment_7660", "id": "reaction_10672912", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672905" ], "products": [ "species_10672909", "species_10672899" ], "modifiers": [ [ "species_10672905", "catalyst" ] ], "additional_components": [ "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393", "DDB_G0268358", "Q54Q46", "DDB_G0284101", "Q54DH7", "DDB_G0292244", "Q1ZXF6", "DDB_G0284555", "Q55E68", "DDB_G0269370", "Q86JC5", "DDB_G0275957", "Q54YX5", "DDB_G0278027", "Q55BU3", "DDB_G0270360", "Q54PP4", "DDB_G0284403", "Q54XP2", "DDB_G0278821", "Q9NI62", "DDB_G0269216", "Q54WL8", "DDB_G0279559", "Q553S5", "DDB_G0275407", "Q7KWK5", "DDB_G0276803", "Q54DV7", "DDB_G0293064", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XS9", "DDB_G0278769", "Q54BG2", "DDB_G0293636", "Q55BS1", "DDB_G0270392", "Q55EC6", "DDB_G0269300", "Q55G43", "DDB_G0268358", "Q54R72", "DDB_G0283359", "Q54TF6", "DDB_G0281779", "Q54TS6", "DDB_G0281585", "Q54FZ3", "DDB_G0290649", "Q54V94", "DDB_G0280529", "Q54N48", "DDB_G0285507", "Q54ST0", "DDB_G0282243", "Q557T0", "DDB_G0273383", "P36415", "DDB_G0269144", "Q54WZ0", "DDB_G0279311", "Q54M41", "DDB_G0286331", "Q54LY9", "DDB_G0286297", "Q55D61", "DDB_G0269192", "Q54E95", "DDB_G0291734", "Q54MH3", "DDB_G0285937", "Q54YS7", "DDB_G0278105", "Q54J75", "DDB_G0288257", "Q55AR8", "DDB_G0271788", "Q54QF2", "DDB_G0283901", "Q54SA7", "DDB_G0282569", "Q54B65", "DDB_G0293876", "Q54HF5", "DDB_G0289501", "Q55A45", "DDB_G0272320", "Q55AB6", "DDB_G0272036", "Q54IF1", "DDB_G0288797", "Q54CB8", "DDB_G0293064", "Q54S04", "DDB_G0282739", "Q54J73", "DDB_G0288259", "Q54NC5", "DDB_G0285395", "Q555Z2", "DDB_G0274797", "Q86I71", "DDB_G0275027", "Q54CT3", "DDB_G0292778", "Q54NJ4", "DDB_G0285213", "Q54WP9", "DDB_G0279507", "P35084", "DDB_G0279193", "Q54MH4", "DDB_G0285843", "Q55BF5", "DDB_G0271312", "Q55CK7", "DDB_G0270020", "Q54NB4", "DDB_G0285361", "Q55A46", "DDB_G0272108", "Q54FA8", "DDB_G0291037", "Q54SG7", "DDB_G0282763", "P54705", "DDB_G0269188", "Q54WV4", "DDB_G0279377", "Q8T295", "DDB_G0274229", "C7G054", "DDB_G0302414", "Q54N41", "DDB_G0285521", "Q86L45", "DDB_G0273003", "Q54HN5", "DDB_G0289337", "Q54RX0", "DDB_G0282863", "Q55EN0", "DDB_G0269006", "Q54ZS8", "DDB_G0277371", "Q86A14", "DDB_G0272676", "Q54CN1", "DDB_G0292846", "Q55BL6", "DDB_G0270450", "Q55G70", "DDB_G0267796", "Q54WM4", "DDB_G0279549", "Q54KR9", "DDB_G0287197", "Q54J05", "DDB_G0288391", "Q54XP4", "DDB_G0278819", "Q86A79", "DDB_G0274799", "Q54GS9", "DDB_G0289933", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55CA3", "DDB_G0270148", "Q54IV3", "DDB_G0288501", "Q54NS6", "DDB_G0285077", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54CU3", "DDB_G0292710", "Q54CE0", "DDB_G0293168", "Q54LG7", "DDB_G0286645", "Q1ZXB1", "DDB_G0291966", "Q54PX4", "DDB_G0284319", "Q54Z08", "DDB_G0277977", "Q54PW8", "DDB_G0284321", "Q54LT3", "DDB_G0286425", "Q553B1", "DDB_G0275443", "Q54LV5", "DDB_G0286395", "Q55A15", "DDB_G0272374", "Q55CI7", "DDB_G0271014", "Q54ZS5", "DDB_G0277375", "Q54P04", "DDB_G0284891", "Q54PX3", "DDB_G0291966", "C7G084", "DDB_G0295793", "Q54KT7", "DDB_G0287131", "Q86A78", "DDB_G0274577", "Q54TL3", "DDB_G0281687", "Q54VI2", "DDB_G0280393" ] }, "reaction_10683372": { "compartment": "compartment_12045", "id": "reaction_10683372", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683362" ], "products": [ "species_10683370" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10683430": { "compartment": "compartment_876", "id": "reaction_10683430", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683426", "species_30389" ], "products": [ "species_10683428" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683348": { "compartment": "compartment_876", "id": "reaction_10683348", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10683344" ], "products": [ "species_10683346" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683434": { "compartment": "compartment_70101", "id": "reaction_10683434", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10683432" ], "products": [ "species_10682591", "species_29420" ], "modifiers": [ [ "species_10683428", "catalyst" ], [ "species_10683346", "catalyst" ] ], "additional_components": [ "species_111349", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10679921": { "compartment": "compartment_12045", "id": "reaction_10679921", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10725767": { "compartment": "compartment_984", "id": "reaction_10725767", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9673044", "species_109276" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10725765": { "compartment": "compartment_984", "id": "reaction_10725765", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_9673044", "species_109276" ], "modifiers": [ [ "species_10725762", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10686978": { "compartment": "compartment_70101", "id": "reaction_10686978", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686974", "species_10686972" ], "products": [ "species_10686976" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10686985": { "compartment": "compartment_876", "id": "reaction_10686985", "reactome": "R-DDI-877187", "name": "P2X7 mediates loss of intracellular K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10686982", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10690134": { "compartment": "compartment_70101", "id": "reaction_10690134", "reactome": "R-DDI-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690130", "species_10673826" ], "products": [ "species_10690132" ], "modifiers": [], "additional_components": [ "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "Q86KB1", "DDB_G0274395", "Q54HT7", "DDB_G0289229", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q55CH0", "DDB_G0271022", "Q54CH1", "DDB_G0292924", "P29447", "DDB_G0294489", "Q86KB1", "DDB_G0274395", "Q1ZXE0", "DDB_G0287849", "Q54HT7", "DDB_G0289229" ] }, "reaction_10690136": { "compartment": "compartment_70101", "id": "reaction_10690136", "reactome": "R-DDI-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673826", "species_1250243" ], "products": [ "species_10673820" ], "modifiers": [], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849" ] }, "reaction_10684160": { "compartment": "compartment_876", "id": "reaction_10684160", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10684157", "catalyst" ] ], "additional_components": [ "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473" ] }, "reaction_10711700": { "compartment": "compartment_7660", "id": "reaction_10711700", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711648" ], "products": [ "species_10711656" ], "modifiers": [ [ "species_10711697", "catalyst" ], [ "species_10711680", "catalyst" ], [ "species_10711695", "catalyst" ], [ "species_10711661", "catalyst" ] ], "additional_components": [ "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q54BV0", "DDB_G0293412", "Q7KWL3", "DDB_G0276815", "Q54EN2", "DDB_G0291438", "Q54ST0", "DDB_G0282243", "C7G018", "DDB_G0302418", "Q55FI4", "DDB_G0268098", "Q55C50", "DDB_G0270230", "Q54PE0", "DDB_G0284621", "Q54UU3", "DDB_G0280823", "Q7KWM6", "DDB_G0272732", "Q54KG8", "DDB_G0287351", "Q55GM5", "DDB_G0267606", "Q54QV4", "DDB_G0283581", "Q550V0", "DDB_G0277019", "Q54VT4", "DDB_G0280147", "Q54XG2", "DDB_G0278983", "Q8T2Q3", "DDB_G0275141", "P14132", "DDB_G0289877", "Q55BA1", "DDB_G0271240", "Q54HT2", "DDB_G0289235", "Q553S0", "DDB_G0275403", "Q54MT2", "DDB_G0285679", "Q54UU6", "DDB_G0280805", "Q54K79", "DDB_G0287537", "Q54EG3", "DDB_G0291526", "Q7KWS8", "DDB_G0276283", "Q54WV7", "DDB_G0279371", "Q54X28", "DDB_G0279245", "Q54VA5", "DDB_G0280489", "P27685", "DDB_G0293742", "Q54ML4", "DDB_G0285875", "Q54S38", "DDB_G0282803", "Q54XT8", "DDB_G0278751", "Q55CW0", "DDB_G0269878", "Q54I41", "DDB_G0289025", "Q55D06", "DDB_G0269830", "Q54JS8", "DDB_G0287891", "Q55EH5", "DDB_G0268898", "Q54GG4", "DDB_G0290181", "Q86IZ9", "DDB_G0274325", "Q54S79", "DDB_G0282623", "Q54WN5", "DDB_G0279601", "Q86IE2", "DDB_G0275633", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55AW0", "DDB_G0271572", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54ZS3", "DDB_G0277279", "Q54N99", "DDB_G0285377", "DDB_G0284053", "DDB_G0275633", "DDB_G0271572" ] }, "reaction_10711868": { "compartment": "compartment_70101", "id": "reaction_10711868", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711840", "species_10711842" ], "products": [ "species_10711850", "species_10711856", "species_10711854", "species_10673208", "species_10711848", "species_10711846", "species_10711860", "species_10711852", "species_10711844", "species_10711842", "species_10711858" ], "modifiers": [ [ "species_10711848", "catalyst" ], [ "species_10711860", "catalyst" ], [ "species_10711866", "catalyst" ], [ "species_10711858", "catalyst" ] ], "additional_components": [ "Q54K66", "DDB_G0287557", "Q54GC0", "DDB_G0290281", "Q76P36", "DDB_G0272308", "Q54W91", "DDB_G0279821", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q54T05", "DDB_G0282099", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q8T1D4", "DDB_G0275601", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q3ZE13", "DDB_G0269980", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54IS0", "DDB_G0288565", "P46793", "DDB_G0276457", "Q556Y4", "DDB_G0273059", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "Q54U04", "DDB_G0281409", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54VD8", "DDB_G0280431", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "O77082", "DDB_G0286117", "Q54YA7", "DDB_G0278331", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54W23", "DDB_G0279961", "Q54I41", "DDB_G0289025", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0280431", "DDB_G0287557", "DDB_G0280431", "DDB_G0278331", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0282099", "DDB_G0288565", "DDB_G0280431", "DDB_G0273059", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10711424": { "compartment": "compartment_7660", "id": "reaction_10711424", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711408" ], "products": [ "species_10711387" ], "modifiers": [ [ "species_10711383", "catalyst" ], [ "species_10711406", "catalyst" ], [ "species_10711378", "catalyst" ], [ "species_10711422", "catalyst" ] ], "additional_components": [ "Q54TD8", "DDB_G0281839", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54W52", "DDB_G0279903", "Q54IM3", "DDB_G0288659", "Q54HJ2", "DDB_G0289415", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54DG4", "DDB_G0292290", "Q75JW2", "DDB_G0272176", "Q54IM3", "DDB_G0288659", "Q54Z27", "DDB_G0277945", "Q54W97", "DDB_G0279809", "DDB_G0277945", "Q54TD8", "DDB_G0281839", "Q54W52", "DDB_G0279903", "Q54HJ2", "DDB_G0289415", "DDB_G0272176", "Q54P34", "DDB_G0284817", "Q54KS4", "DDB_G0287147", "Q54HJ2", "DDB_G0289415" ] }, "reaction_10683571": { "compartment": "compartment_17951", "id": "reaction_10683571", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389556", "species_389548" ], "products": [ "species_193465", "species_113602", "species_389537", "species_389536" ], "modifiers": [ [ "species_10683568", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10716318": { "compartment": "compartment_70101", "id": "reaction_10716318", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680089", "species_29356" ], "products": [ "species_10683769", "species_29372" ], "modifiers": [ [ "species_10716315", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10692828": { "compartment": "compartment_876", "id": "reaction_10692828", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806240" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692825", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693245": { "compartment": "compartment_876", "id": "reaction_10693245", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10725879": { "compartment": "compartment_876", "id": "reaction_10725879", "reactome": "R-DDI-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530" ], "products": [ "species_10725877" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10723407": { "compartment": "compartment_876", "id": "reaction_10723407", "reactome": "R-DDI-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723395" ], "products": [ "species_10723405" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049" ] }, "reaction_10723412": { "compartment": "compartment_876", "id": "reaction_10723412", "reactome": "R-DDI-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723395" ], "products": [ "species_10683530", "species_29420" ], "modifiers": [ [ "species_10723409", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "Q54F64", "DDB_G0291085", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q54B37", "DDB_G0293978", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10723417": { "compartment": "compartment_876", "id": "reaction_10723417", "reactome": "R-DDI-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683530", "species_29356" ], "products": [ "species_10723395", "species_29372" ], "modifiers": [ [ "species_10723414", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10709853": { "compartment": "compartment_7660", "id": "reaction_10709853", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709849", "species_10709820" ], "products": [ "species_10709824" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709818": { "compartment": "compartment_7660", "id": "reaction_10709818", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706016", "species_10706025", "species_10706023", "species_10709816" ], "products": [ "species_10706029" ], "modifiers": [], "additional_components": [ "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709827": { "compartment": "compartment_7660", "id": "reaction_10709827", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709824" ], "products": [ "species_113582", "species_10705998" ], "modifiers": [ [ "species_10709824", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10706007": { "compartment": "compartment_7660", "id": "reaction_10706007", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10706000" ], "products": [ "species_113582", "species_10706004" ], "modifiers": [ [ "species_10706000", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709842": { "compartment": "compartment_7660", "id": "reaction_10709842", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709792" ], "products": [ "species_10709816" ], "modifiers": [ [ "species_10709839", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q556S0", "DDB_G0273125", "Q55DD6", "DDB_G0269692" ] }, "reaction_10706034": { "compartment": "compartment_7660", "id": "reaction_10706034", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10706029" ], "products": [ "species_113541", "species_10706031" ], "modifiers": [ [ "species_10706029", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303", "Q1ZXF2", "DDB_G0284713", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54YJ7", "DDB_G0278203", "Q54CR9", "DDB_G0292760", "Q54P54", "DDB_G0284785", "Q54LY5", "DDB_G0286303" ] }, "reaction_10709795": { "compartment": "compartment_7660", "id": "reaction_10709795", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10706004" ], "products": [ "species_10709792" ], "modifiers": [ [ "species_10706004", "catalyst" ] ], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54UC0", "DDB_G0281167", "Q54LY5", "DDB_G0286303" ] }, "reaction_10695511": { "compartment": "compartment_70101", "id": "reaction_10695511", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10695509" ], "products": [ "species_29370", "species_10683624", "species_10685605" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10695587": { "compartment": "compartment_70101", "id": "reaction_10695587", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693765", "species_10695583" ], "products": [ "species_10695585" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102" ] }, "reaction_10696677": { "compartment": "compartment_70101", "id": "reaction_10696677", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695585" ], "products": [ "species_10695631", "species_10695581" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_179838", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "Q6UK63", "DDB_G0287855", "Q553U6", "DDB_G0275023", "Q55FT9", "DDB_G0267956", "O96622", "DDB_G0277825", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q54HF1", "DDB_G0289505", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q55CU2", "DDB_G0269902", "species_113592", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "species_179838", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519" ] }, "reaction_10695513": { "compartment": "compartment_70101", "id": "reaction_10695513", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683631" ], "products": [ "species_10683629", "species_10695509" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10695633": { "compartment": "compartment_70101", "id": "reaction_10695633", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680919", "species_10695631" ], "products": [ "species_10693810" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "species_29370", "Q554S6", "DDB_G0274131", "O96623", "DDB_G0282813", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "O96624", "DDB_G0292804", "O96621", "DDB_G0272106", "P42528", "DDB_G0283755", "Q553U6", "DDB_G0275023", "O96622", "DDB_G0277825", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "O96626", "DDB_G0288319", "O96625", "DDB_G0269102" ] }, "reaction_10721256": { "compartment": "compartment_70101", "id": "reaction_10721256", "reactome": "R-DDI-8932243", "name": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676998", "species_71284" ], "products": [ "species_71285", "species_10721248" ], "modifiers": [ [ "species_10721253", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0277003" ] }, "reaction_10721245": { "compartment": "compartment_7660", "id": "reaction_10721245", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10672551" ], "products": [ "species_10721237", "species_77502" ], "modifiers": [ [ "species_10721242", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10721301": { "compartment": "compartment_70101", "id": "reaction_10721301", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_10721293", "species_71285" ], "modifiers": [ [ "species_10721298", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0278427" ] }, "reaction_10721279": { "compartment": "compartment_70101", "id": "reaction_10721279", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_71284" ], "products": [ "species_10721267", "species_71285" ], "modifiers": [ [ "species_10721276", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10721214": { "compartment": "compartment_70101", "id": "reaction_10721214", "reactome": "R-DDI-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10673088" ], "products": [ "species_71285", "species_10721209" ], "modifiers": [ [ "species_10721211", "catalyst" ] ], "additional_components": [ "DDB_G0293742", "DDB_G0293742", "DDB_G0291556" ] }, "reaction_10721234": { "compartment": "compartment_70101", "id": "reaction_10721234", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10676967" ], "products": [ "species_71285", "species_10721226" ], "modifiers": [ [ "species_10721231", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10679876": { "compartment": "compartment_70101", "id": "reaction_10679876", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644", "species_29368" ], "products": [ "species_29366", "species_194735", "species_29356" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679891": { "compartment": "compartment_13231", "id": "reaction_10679891", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194688", "species_194725" ], "products": [ "species_194704", "species_194668" ], "modifiers": [ [ "species_10679888", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10679622": { "compartment": "compartment_70101", "id": "reaction_10679622", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_191265", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679843": { "compartment": "compartment_17951", "id": "reaction_10679843", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10725944": { "compartment": "compartment_70101", "id": "reaction_10725944", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_29366", "species_469662" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10718908": { "compartment": "compartment_70101", "id": "reaction_10718908", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10718905", "catalyst" ] ], "additional_components": [ "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q54QP6", "DDB_G0283709", "Q54ID7", "DDB_G0288817", "Q86HV4", "DDB_G0276427" ] }, "reaction_10679883": { "compartment": "compartment_70101", "id": "reaction_10679883", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194723", "species_29368" ], "products": [ "species_29366", "species_29356", "species_194657" ], "modifiers": [ [ "species_10679873", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10679552": { "compartment": "compartment_70101", "id": "reaction_10679552", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191269", "species_29368" ], "products": [ "species_29366", "species_191309", "species_29356" ], "modifiers": [ [ "species_10679549", "catalyst" ] ], "additional_components": [ "Q54BK7", "DDB_G0293584", "species_113596" ] }, "reaction_10679863": { "compartment": "compartment_70101", "id": "reaction_10679863", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679729": { "compartment": "compartment_70101", "id": "reaction_10679729", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192114", "species_29360" ], "products": [ "species_70106", "species_73473", "species_192136" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679632": { "compartment": "compartment_70101", "id": "reaction_10679632", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29370", "species_191362", "species_113528", "species_29372" ], "modifiers": [ [ "species_10679629", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10679834": { "compartment": "compartment_876", "id": "reaction_10679834", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193416", "species_113592", "species_29356" ], "products": [ "species_29370", "species_193479", "species_29372" ], "modifiers": [ [ "species_10679831", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10714962": { "compartment": "compartment_12045", "id": "reaction_10714962", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10679918", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10679836": { "compartment": "compartment_17951", "id": "reaction_10679836", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193442", "species_113535" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679590": { "compartment": "compartment_70101", "id": "reaction_10679590", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10679587", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10679881": { "compartment": "compartment_70101", "id": "reaction_10679881", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_73473", "species_113528", "species_194667" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679839": { "compartment": "compartment_17951", "id": "reaction_10679839", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10679600": { "compartment": "compartment_70101", "id": "reaction_10679600", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10679597", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10679620": { "compartment": "compartment_70101", "id": "reaction_10679620", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_191265", "species_29364" ], "products": [ "species_29366", "species_191269", "species_111294" ], "modifiers": [ [ "species_10679617", "catalyst" ] ], "additional_components": [ "Q54DR1", "DDB_G0292072", "species_29926" ] }, "reaction_10679749": { "compartment": "compartment_17951", "id": "reaction_10679749", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_192342", "species_113575" ], "modifiers": [ [ "species_10679746", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10679714": { "compartment": "compartment_70101", "id": "reaction_10679714", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_176478", "species_29368" ], "products": [ "species_29366", "species_192148", "species_29356" ], "modifiers": [ [ "species_10679711", "catalyst" ] ], "additional_components": [ "Q55D54", "DDB_G0279611", "Q55D52", "DDB_G0279611", "species_71067", "Q54WK0", "DDB_G0279611" ] }, "reaction_10681907": { "compartment": "compartment_70101", "id": "reaction_10681907", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_8963870" ], "products": [ "species_29366", "species_8963879", "species_29356" ], "modifiers": [ [ "species_10681904", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10679564": { "compartment": "compartment_70101", "id": "reaction_10679564", "reactome": "R-DDI-191303", "name": "FDPS dimer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679913": { "compartment": "compartment_70101", "id": "reaction_10679913", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_194657" ], "products": [ "species_73473", "species_70106", "species_194661", "species_113528" ], "modifiers": [ [ "species_10679878", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10679784": { "compartment": "compartment_70101", "id": "reaction_10679784", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_176626" ], "products": [ "species_70106", "species_73473", "species_193079" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679582": { "compartment": "compartment_70101", "id": "reaction_10679582", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191374" ], "products": [ "species_76194", "species_29366", "species_191424" ], "modifiers": [ [ "species_10679579", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10686933": { "compartment": "compartment_70101", "id": "reaction_10686933", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193066" ], "products": [ "species_29366", "species_193132" ], "modifiers": [ [ "species_10686930", "catalyst" ] ], "additional_components": [ "Q54WA9", "DDB_G0279783" ] }, "reaction_10679739": { "compartment": "compartment_17951", "id": "reaction_10679739", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192342", "species_141343" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10701893": { "compartment": "compartment_17957", "id": "reaction_10701893", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10701890", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10679567": { "compartment": "compartment_70101", "id": "reaction_10679567", "reactome": "R-DDI-191322", "name": "FDPS dimer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10679561", "catalyst" ] ], "additional_components": [ "Q9NH03", "DDB_G0278735", "species_29926" ] }, "reaction_10679871": { "compartment": "compartment_876", "id": "reaction_10679871", "reactome": "R-DDI-194153", "name": "ABCC3 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_194156" ], "products": [ "species_29370", "species_192483", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:16525", "CHEBI:28865", "CHEBI:36274", "CHEBI:17687", "CHEBI:16755", "CHEBI:16359", "CHEBI:9407", "CHEBI:28865", "CHEBI:36274", "DDB_G0285165" ] }, "reaction_10679770": { "compartment": "compartment_70101", "id": "reaction_10679770", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10726092": { "compartment": "compartment_70101", "id": "reaction_10726092", "reactome": "R-DDI-9717830", "name": "GGPS1 hexamer transfers IPPP to GPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191409" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679782": { "compartment": "compartment_70101", "id": "reaction_10679782", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193079" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10679779", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10679928": { "compartment": "compartment_70101", "id": "reaction_10679928", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196366" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679841": { "compartment": "compartment_17951", "id": "reaction_10679841", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10726095": { "compartment": "compartment_70101", "id": "reaction_10726095", "reactome": "R-DDI-9717834", "name": "GGPS1 hexamer transfers IPPP to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_191324" ], "products": [ "species_191409", "species_111294" ], "modifiers": [ [ "species_10726089", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926" ] }, "reaction_10679861": { "compartment": "compartment_70101", "id": "reaction_10679861", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192194", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193835" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679911": { "compartment": "compartment_70101", "id": "reaction_10679911", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194644" ], "products": [ "species_29366", "species_194633" ], "modifiers": [ [ "species_10679908", "catalyst" ] ], "additional_components": [ "Q54PP1", "DDB_G0284407", "Q55GJ9", "DDB_G0267448" ] }, "reaction_10679572": { "compartment": "compartment_70101", "id": "reaction_10679572", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_29356", "species_76183" ], "products": [ "species_70106", "species_76194", "species_191374" ], "modifiers": [ [ "species_10679569", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10679610": { "compartment": "compartment_70101", "id": "reaction_10679610", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10679607", "catalyst" ] ], "additional_components": [ "species_29926", "Q9NH02", "DDB_G0290011" ] }, "reaction_10679899": { "compartment": "compartment_70101", "id": "reaction_10679899", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_194634", "species_29368" ], "products": [ "species_29366", "species_194644", "species_29460", "species_29356" ], "modifiers": [ [ "species_10679896", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10722153": { "compartment": "compartment_70101", "id": "reaction_10722153", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191265", "species_29356" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10722150", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10679926": { "compartment": "compartment_70101", "id": "reaction_10679926", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_73473", "species_196344" ], "modifiers": [ [ "species_10679767", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10679859": { "compartment": "compartment_70101", "id": "reaction_10679859", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_70106", "species_73473", "species_193724" ], "modifiers": [ [ "species_10679726", "catalyst" ] ], "additional_components": [ "Q54TU9", "DDB_G0281487", "Q54XR1", "DDB_G0281487" ] }, "reaction_10673670": { "compartment": "compartment_70101", "id": "reaction_10673670", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673388" ], "products": [ "species_10673296", "species_10673386", "species_29420" ], "modifiers": [ [ "species_10673386", "catalyst" ] ], "additional_components": [ "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961" ] }, "reaction_10673390": { "compartment": "compartment_70101", "id": "reaction_10673390", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673338", "species_10673386" ], "products": [ "species_10673388" ], "modifiers": [], "additional_components": [ "species_29420", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q54FQ8", "DDB_G0290693", "species_29420", "Q54EY2", "DDB_G0291271", "Q54RF3", "DDB_G0283163", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q54FM3", "DDB_G0290759", "Q54I81", "DDB_G0288961", "Q869N9", "DDB_G0271862" ] }, "reaction_10712164": { "compartment": "compartment_7660", "id": "reaction_10712164", "reactome": "R-DDI-6798372", "name": "ATM phosphorylates DYRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712158" ], "products": [ "species_113582", "species_10712162" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0293750", "DDB_G0293750", "DDB_G0275845" ] }, "reaction_10714907": { "compartment": "compartment_7660", "id": "reaction_10714907", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714903", "species_10676372" ], "products": [ "species_10714905" ], "modifiers": [], "additional_components": [ "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601", "Q54G78", "DDB_G0290331" ] }, "reaction_10700599": { "compartment": "compartment_7660", "id": "reaction_10700599", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698368", "species_10700571" ], "products": [ "species_10698305", "species_10700596" ], "modifiers": [ [ "species_10698368", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0268098", "DDB_G0287693", "DDB_G0268098", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700587": { "compartment": "compartment_7660", "id": "reaction_10700587", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700571" ], "products": [ "species_10698305", "species_10700585" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268098", "DDB_G0287693", "Q55FI4", "DDB_G0268098", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676662": { "compartment": "compartment_114521", "id": "reaction_10676662", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676659", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10676758": { "compartment": "compartment_876", "id": "reaction_10676758", "reactome": "R-DDI-139855", "name": "P2X1-mediated entry of Ca++ from plasma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10676755", "catalyst" ] ], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10692427": { "compartment": "compartment_161320", "id": "reaction_10692427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605592", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692508": { "compartment": "compartment_876", "id": "reaction_10692508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429776", "species_29356" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10692505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10692400": { "compartment": "compartment_161320", "id": "reaction_10692400", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605608", "species_1605715" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10692397", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10693818": { "compartment": "compartment_876", "id": "reaction_10693818", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1861782", "species_29356" ], "products": [ "species_70113", "species_429807" ], "modifiers": [ [ "species_10693815", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10692360": { "compartment": "compartment_161320", "id": "reaction_10692360", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10692425": { "compartment": "compartment_161320", "id": "reaction_10692425", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10692422", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10692437": { "compartment": "compartment_876", "id": "reaction_10692437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_29356" ], "products": [ "species_1861754", "species_1606609" ], "modifiers": [ [ "species_10692434", "catalyst" ] ], "additional_components": [ "Q54BK2", "DDB_G0293538" ] }, "reaction_10692417": { "compartment": "compartment_161320", "id": "reaction_10692417", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605601", "species_1605637" ], "modifiers": [ [ "species_10692414", "catalyst" ] ], "additional_components": [ "Q55B10", "DDB_G0271490", "Q54EG4", "DDB_G0291524" ] }, "reaction_10702402": { "compartment": "compartment_876", "id": "reaction_10702402", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684166", "species_10684155" ], "products": [ "species_10702400" ], "modifiers": [], "additional_components": [ "Q55CT1", "DDB_G0269912", "Q54L96", "DDB_G0286763", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54PE8", "DDB_G0289473", "Q54HG6", "DDB_G0289473", "P54678", "DDB_G0277861", "Q55CT1", "DDB_G0269912", "Q54PE8", "DDB_G0289473", "Q54L96", "DDB_G0286763" ] }, "reaction_10688485": { "compartment": "compartment_74700", "id": "reaction_10688485", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688478", "species_10685814" ], "products": [ "species_10688480" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688006": { "compartment": "compartment_70101", "id": "reaction_10688006", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687994", "species_10685814" ], "products": [ "species_10687996" ], "modifiers": [], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10688483": { "compartment": "compartment_74700", "id": "reaction_10688483", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10688480" ], "products": [ "species_10686011" ], "modifiers": [ [ "species_10688480", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10678168": { "compartment": "compartment_984", "id": "reaction_10678168", "reactome": "R-DDI-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678162", "species_168948" ], "products": [ "species_10678166" ], "modifiers": [], "additional_components": [ "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628", "Q54BH0", "DDB_G0293628", "Q54K36", "DDB_G0293628" ] }, "reaction_10719248": { "compartment": "compartment_984", "id": "reaction_10719248", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2186967", "species_10677632" ], "products": [ "species_10719246" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_2186967" ] }, "reaction_10688009": { "compartment": "compartment_70101", "id": "reaction_10688009", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153" ], "products": [ "species_10678140" ], "modifiers": [ [ "species_10688001", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10677638": { "compartment": "compartment_984", "id": "reaction_10677638", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677632", "species_166005" ], "products": [ "species_10677634" ], "modifiers": [ [ "species_10677636", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE8", "DDB_G0288097", "Q54JE7", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "species_6803081", "DDB_G0271242" ] }, "reaction_10714923": { "compartment": "compartment_984", "id": "reaction_10714923", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340" ], "products": [ "species_10714865" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10688004": { "compartment": "compartment_876", "id": "reaction_10688004", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10687996" ], "products": [ "species_10688001" ], "modifiers": [ [ "species_10687996", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454", "Q54LU8", "DDB_G0286465", "Q559R2", "DDB_G0272454" ] }, "reaction_10714873": { "compartment": "compartment_984", "id": "reaction_10714873", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_166005" ], "products": [ "species_10714871" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_6803081" ] }, "reaction_10714869": { "compartment": "compartment_984", "id": "reaction_10714869", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714865", "species_181015" ], "products": [ "species_10714867" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10704731": { "compartment": "compartment_70101", "id": "reaction_10704731", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_71285", "species_5687529" ], "modifiers": [ [ "species_10704728", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10726173": { "compartment": "compartment_70101", "id": "reaction_10726173", "reactome": "R-DDI-9751024", "name": "SLC29A1,2 transport 6MP from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9751015" ], "products": [ "species_9748998" ], "modifiers": [ [ "species_10726170", "catalyst" ] ], "additional_components": [ "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10726136": { "compartment": "compartment_70101", "id": "reaction_10726136", "reactome": "R-DDI-9748999", "name": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9748960" ], "products": [ "species_29370", "species_9748947" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726125": { "compartment": "compartment_70101", "id": "reaction_10726125", "reactome": "R-DDI-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29356", "species_9748959" ], "products": [ "species_70106", "species_9748970", "species_29404", "species_111294", "species_76577" ], "modifiers": [ [ "species_10726122", "catalyst" ] ], "additional_components": [ "P32073", "DDB_G0281551" ] }, "reaction_10726134": { "compartment": "compartment_70101", "id": "reaction_10726134", "reactome": "R-DDI-9748996", "name": "GST dimers cleave AZA to 6MP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9748994" ], "products": [ "species_9748975", "species_9748998" ], "modifiers": [ [ "species_10678993", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10726163": { "compartment": "compartment_70101", "id": "reaction_10726163", "reactome": "R-DDI-9750617", "name": "ABCC5 transports TPMP substrates from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750557", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750602", "species_29372" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_9748992", "species_9748970", "species_9748959", "pubchem.compound:3037883", "CHEBI:80613", "CHEBI:80612", "pubchem.compound:3037883", "CHEBI:2332", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726129": { "compartment": "compartment_70101", "id": "reaction_10726129", "reactome": "R-DDI-9748969", "name": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9749033" ], "products": [ "species_29370", "species_9749032" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10726118": { "compartment": "compartment_70101", "id": "reaction_10726118", "reactome": "R-DDI-9748945", "name": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748992", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_9748959" ], "modifiers": [ [ "species_10674001", "catalyst" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701" ] }, "reaction_10726127": { "compartment": "compartment_70101", "id": "reaction_10726127", "reactome": "R-DDI-9748963", "name": "GUK1 phosphorylates 6TdGMP to 6TdGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749031", "species_113592" ], "products": [ "species_29370", "species_9749033" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10726131": { "compartment": "compartment_70101", "id": "reaction_10726131", "reactome": "R-DDI-9748991", "name": "XDH oxidises 6MP to 6TU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_9748998", "species_29356" ], "products": [ "species_70106", "species_73473", "species_9748978" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10726120": { "compartment": "compartment_70101", "id": "reaction_10726120", "reactome": "R-DDI-9748949", "name": "GUK1 phosphorylates 6TGMP to 6TGDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9748970", "species_113592" ], "products": [ "species_29370", "species_9748960" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "DDB_G0279001" ] }, "reaction_10678801": { "compartment": "compartment_7660", "id": "reaction_10678801", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647" ], "products": [ "species_10678645", "species_10678597" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0287259" ] }, "reaction_10678652": { "compartment": "compartment_7660", "id": "reaction_10678652", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678647", "species_10669917" ], "products": [ "species_10678649" ], "modifiers": [ [ "species_10678647", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678780": { "compartment": "compartment_70101", "id": "reaction_10678780", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678775" ], "products": [ "species_10678777" ], "modifiers": [ [ "species_10676850", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q8T2F2", "DDB_G0277439", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678754": { "compartment": "compartment_7660", "id": "reaction_10678754", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678749" ], "products": [ "species_113582", "species_10678751" ], "modifiers": [ [ "species_10678749", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678741": { "compartment": "compartment_7660", "id": "reaction_10678741", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678649" ], "products": [ "species_10678645", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678784": { "compartment": "compartment_70101", "id": "reaction_10678784", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678782" ], "products": [ "species_10670153", "species_10670512" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679249": { "compartment": "compartment_7660", "id": "reaction_10679249", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678747", "species_10669684" ], "products": [ "species_10678749" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q8T2F2", "DDB_G0277439", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "P34112", "DDB_G0272813", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q1ZXI1", "DDB_G0279085", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10679167": { "compartment": "compartment_70101", "id": "reaction_10679167", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10679160" ], "products": [ "species_10679164" ], "modifiers": [ [ "species_10679160", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676858": { "compartment": "compartment_70101", "id": "reaction_10676858", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676836", "species_10676831", "species_10676841", "species_10676846" ], "products": [ "species_10676848" ], "modifiers": [], "additional_components": [ "DDB_G0292134", "DDB_G0292676", "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10679169": { "compartment": "compartment_70101", "id": "reaction_10679169", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679164" ], "products": [ "species_10670153", "species_10676850" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q556Y9", "DDB_G0273201", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "P0CG77", "DDB_G0286907", "Q54J83", "DDB_G0288223", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54TK0", "DDB_G0281703", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678858": { "compartment": "compartment_70101", "id": "reaction_10678858", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678844" ], "products": [ "species_10678856", "species_10670153", "species_10678838" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54MZ3", "DDB_G0285601", "Q54KM3", "DDB_G0287259", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678769": { "compartment": "compartment_70101", "id": "reaction_10678769", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670512", "species_10678765" ], "products": [ "species_10678767" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q86HN7", "DDB_G0274503", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678852": { "compartment": "compartment_70101", "id": "reaction_10678852", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678767" ], "products": [ "species_10678782" ], "modifiers": [ [ "species_10678767", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54D58", "DDB_G0292470", "P0CG78", "DDB_G0289449", "Q54NC6", "DDB_G0285349", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54TK0", "DDB_G0281703", "Q54KM3", "DDB_G0287259", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q86HN7", "DDB_G0274503", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q86HN7", "DDB_G0274503", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54WX4", "DDB_G0279343", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678854": { "compartment": "compartment_70101", "id": "reaction_10678854", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678809" ], "products": [ "species_10670153", "species_10678797" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10679162": { "compartment": "compartment_70101", "id": "reaction_10679162", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850", "species_10679158" ], "products": [ "species_10679160" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0270814", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q55BN8", "DDB_G0270814", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676852": { "compartment": "compartment_70101", "id": "reaction_10676852", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676848", "species_10670505" ], "products": [ "species_10676850" ], "modifiers": [], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678862": { "compartment": "compartment_70101", "id": "reaction_10678862", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679243" ], "products": [ "species_10678747", "species_10670680", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0290551", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678812": { "compartment": "compartment_70101", "id": "reaction_10678812", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678805" ], "products": [ "species_10678809" ], "modifiers": [ [ "species_10678797", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10676856": { "compartment": "compartment_70101", "id": "reaction_10676856", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676841", "species_10676846" ], "products": [ "species_10676854" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201" ] }, "reaction_10678868": { "compartment": "compartment_70101", "id": "reaction_10678868", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676850" ], "products": [ "species_10678797", "species_10678866" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q556Y9", "DDB_G0273201", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q54CV5", "DDB_G0292676", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54DM1", "DDB_G0292134", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54MZ3", "DDB_G0285601", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54CV5", "DDB_G0292676" ] }, "reaction_10725854": { "compartment": "compartment_7660", "id": "reaction_10725854", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725851", "species_10669917" ], "products": [ "species_10679243" ], "modifiers": [ [ "species_10725851", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54FX2", "DDB_G0290551", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54FX2", "DDB_G0290551", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10678795": { "compartment": "compartment_7660", "id": "reaction_10678795", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678645" ], "products": [ "species_10678645" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113", "DDB_G0274503" ] }, "reaction_10678847": { "compartment": "compartment_70101", "id": "reaction_10678847", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10678842" ], "products": [ "species_10678844" ], "modifiers": [ [ "species_10678838", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q7KWS8", "DDB_G0276283", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10693242": { "compartment": "compartment_172574", "id": "reaction_10693242", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691994": { "compartment": "compartment_12045", "id": "reaction_10691994", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_29356" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10691991", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54WR4", "DDB_G0279483" ] }, "reaction_10691844": { "compartment": "compartment_12045", "id": "reaction_10691844", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_109395", "species_426925" ], "modifiers": [ [ "species_10691841", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691704": { "compartment": "compartment_12045", "id": "reaction_10691704", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10716710": { "compartment": "compartment_876", "id": "reaction_10716710", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10716707", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10691923": { "compartment": "compartment_12045", "id": "reaction_10691923", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10691920", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10691709": { "compartment": "compartment_12045", "id": "reaction_10691709", "reactome": "R-DDI-1482696", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691773": { "compartment": "compartment_12045", "id": "reaction_10691773", "reactome": "R-DDI-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691770", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693140": { "compartment": "compartment_876", "id": "reaction_10693140", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10710251": { "compartment": "compartment_876", "id": "reaction_10710251", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694502", "species_29356" ], "products": [ "species_1861754", "species_5694457" ], "modifiers": [ [ "species_10710248", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10693123": { "compartment": "compartment_171062", "id": "reaction_10693123", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693332": { "compartment": "compartment_20699", "id": "reaction_10693332", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10693329", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10693135": { "compartment": "compartment_876", "id": "reaction_10693135", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_202247", "species_29372" ], "modifiers": [ [ "species_10693132", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927" ] }, "reaction_10691817": { "compartment": "compartment_12045", "id": "reaction_10691817", "reactome": "R-DDI-1482920", "name": "PG is hydrolyzed to 2-acyl LPG by PLA2[14]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498730", "species_1524021" ], "modifiers": [ [ "species_10691814", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691802": { "compartment": "compartment_12045", "id": "reaction_10691802", "reactome": "R-DDI-1482892", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498729", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10691812": { "compartment": "compartment_12045", "id": "reaction_10691812", "reactome": "R-DDI-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1498740", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691805": { "compartment": "compartment_70616", "id": "reaction_10691805", "reactome": "R-DDI-1482894", "name": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524089" ], "products": [ "species_1498773", "species_1524083" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691683": { "compartment": "compartment_12045", "id": "reaction_10691683", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10691907": { "compartment": "compartment_70101", "id": "reaction_10691907", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_264618" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10691904", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10693310": { "compartment": "compartment_20699", "id": "reaction_10693310", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10693137": { "compartment": "compartment_20699", "id": "reaction_10693137", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693277": { "compartment": "compartment_20699", "id": "reaction_10693277", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806159", "species_29356" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10717024": { "compartment": "compartment_70101", "id": "reaction_10717024", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_8849958", "species_29372" ], "modifiers": [ [ "species_10717021", "catalyst" ] ], "additional_components": [ "species_202247", "species_179838", "species_179856", "species_1806205", "species_6810408", "species_1806159", "Q54FY6", "DDB_G0290653", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630" ] }, "reaction_10716932": { "compartment": "compartment_12045", "id": "reaction_10716932", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10716927", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10691872": { "compartment": "compartment_20699", "id": "reaction_10691872", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_109395", "species_429785" ], "modifiers": [ [ "species_10691869", "catalyst" ] ], "additional_components": [ "Q54XM0", "DDB_G0278947", "Q55AQ3", "DDB_G0271794", "species_29418", "species_29926", "Q8T2Q6", "DDB_G0275235" ] }, "reaction_10691789": { "compartment": "compartment_12045", "id": "reaction_10691789", "reactome": "R-DDI-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693250": { "compartment": "compartment_171062", "id": "reaction_10693250", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806205", "species_29356" ], "products": [ "species_1806259", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10710279": { "compartment": "compartment_70101", "id": "reaction_10710279", "reactome": "R-DDI-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694568" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10710276", "catalyst" ] ], "additional_components": [ "Q54QE7", "DDB_G0291476", "Q54EK1", "DDB_G0291476" ] }, "reaction_10691810": { "compartment": "compartment_12045", "id": "reaction_10691810", "reactome": "R-DDI-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498722", "species_1524021" ], "modifiers": [ [ "species_10691807", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691822": { "compartment": "compartment_12045", "id": "reaction_10691822", "reactome": "R-DDI-1482932", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498737", "species_1524021" ], "modifiers": [ [ "species_10691819", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10674942": { "compartment": "compartment_12045", "id": "reaction_10674942", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_76194", "species_426755" ], "modifiers": [ [ "species_10674939", "catalyst" ] ], "additional_components": [ "Q54EU4", "DDB_G0291332", "Q54IG1", "DDB_G0288863", "Q554U0", "DDB_G0274969", "Q54IT8", "DDB_G0288523" ] }, "reaction_10691795": { "compartment": "compartment_12045", "id": "reaction_10691795", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691755", "catalyst" ] ], "additional_components": [ "Q54QX6", "DDB_G0283553", "Q54QX5", "DDB_G0283553" ] }, "reaction_10691697": { "compartment": "compartment_12045", "id": "reaction_10691697", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10691999": { "compartment": "compartment_12045", "id": "reaction_10691999", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_1500646", "species_264618" ], "modifiers": [ [ "species_10691996", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10715867": { "compartment": "compartment_70101", "id": "reaction_10715867", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693218", "species_10715851" ], "products": [ "species_10715865" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693285": { "compartment": "compartment_20699", "id": "reaction_10693285", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_1524146", "species_29372" ], "modifiers": [ [ "species_10693274", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10692026": { "compartment": "compartment_20699", "id": "reaction_10692026", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691932" ], "products": [ "species_10692024" ], "modifiers": [], "additional_components": [ "species_426925", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10691650": { "compartment": "compartment_12045", "id": "reaction_10691650", "reactome": "R-DDI-1482571", "name": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10693112": { "compartment": "compartment_20699", "id": "reaction_10693112", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10693109", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10691800": { "compartment": "compartment_12045", "id": "reaction_10691800", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_76194", "species_1500594" ], "modifiers": [ [ "species_10691797", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10693081": { "compartment": "compartment_20699", "id": "reaction_10693081", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524146", "species_113592" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10693078", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691743": { "compartment": "compartment_70616", "id": "reaction_10691743", "reactome": "R-DDI-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524079", "species_1524072" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10691737", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10691957": { "compartment": "compartment_70616", "id": "reaction_10691957", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110577", "species_1524101" ], "products": [ "species_1524064", "species_159450" ], "modifiers": [ [ "species_10691954", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10692991": { "compartment": "compartment_20699", "id": "reaction_10692991", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_1806217", "species_29372" ], "modifiers": [ [ "species_10692988", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10691692": { "compartment": "compartment_12045", "id": "reaction_10691692", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498724", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692777": { "compartment": "compartment_876", "id": "reaction_10692777", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10692774", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691648": { "compartment": "compartment_17906", "id": "reaction_10691648", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500580", "species_1500578" ], "products": [ "species_76194", "species_1500590" ], "modifiers": [ [ "species_10691645", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10691934": { "compartment": "compartment_20699", "id": "reaction_10691934", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10691930" ], "products": [ "species_1524146", "species_10691932" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10686815": { "compartment": "compartment_12045", "id": "reaction_10686815", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76114", "species_1500578" ], "products": [ "species_76194", "species_1500604" ], "modifiers": [ [ "species_10674935", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10693288": { "compartment": "compartment_876", "id": "reaction_10693288", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_1806224" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10691685": { "compartment": "compartment_12045", "id": "reaction_10691685", "reactome": "R-DDI-1482629", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715945": { "compartment": "compartment_70101", "id": "reaction_10715945", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693303": { "compartment": "compartment_20699", "id": "reaction_10693303", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693076", "species_10693301" ], "products": [ "species_10693078" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "DDB_G0286479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "CHEBI:15996", "Q54LR9", "DDB_G0286479", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479" ] }, "reaction_10691776": { "compartment": "compartment_70616", "id": "reaction_10691776", "reactome": "R-DDI-1482847", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524047" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10691707": { "compartment": "compartment_12045", "id": "reaction_10691707", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498722", "species_1500578" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10691689", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10718992": { "compartment": "compartment_12045", "id": "reaction_10718992", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_392417" ], "products": [ "species_1806234", "species_33625" ], "modifiers": [ [ "species_10718989", "catalyst" ] ], "additional_components": [ "Q54RM1", "DDB_G0283035", "Q8MPQ7", "DDB_G0280053", "Q55CR2", "DDB_G0269940", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q86KG4", "DDB_G0272498", "Q86HV4", "DDB_G0276427" ] }, "reaction_10691655": { "compartment": "compartment_12045", "id": "reaction_10691655", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_76194", "species_426639" ], "modifiers": [ [ "species_10691652", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10722413": { "compartment": "compartment_17906", "id": "reaction_10722413", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10722410", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10691666": { "compartment": "compartment_17906", "id": "reaction_10691666", "reactome": "R-DDI-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590", "species_29356" ], "products": [ "species_1524103", "species_1500580" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715912": { "compartment": "compartment_171062", "id": "reaction_10715912", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10715903", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691680": { "compartment": "compartment_12045", "id": "reaction_10691680", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975614", "species_29356" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10715948": { "compartment": "compartment_70101", "id": "reaction_10715948", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809774", "species_29356" ], "products": [ "species_422529", "species_29372" ], "modifiers": [ [ "species_10715940", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691792": { "compartment": "compartment_12045", "id": "reaction_10691792", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_29356" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10691677", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710324": { "compartment": "compartment_17906", "id": "reaction_10710324", "reactome": "R-DDI-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696069", "species_5696066" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10710321", "catalyst" ] ], "additional_components": [ "species_6797635", "species_6814795", "species_1602448", "species_417891", "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "species_29926", "Q54HN2", "DDB_G0289343" ] }, "reaction_10692978": { "compartment": "compartment_876", "id": "reaction_10692978", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_1806240" ], "modifiers": [ [ "species_10692975", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10715905": { "compartment": "compartment_70101", "id": "reaction_10715905", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692890", "species_10715901" ], "products": [ "species_10715903" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721170": { "compartment": "compartment_5460", "id": "reaction_10721170", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_8934414", "species_113548" ], "modifiers": [ [ "species_10721167", "catalyst" ] ], "additional_components": [ "DDB_G0284755" ] }, "reaction_10691765": { "compartment": "compartment_12045", "id": "reaction_10691765", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_29356" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10691762", "catalyst" ] ], "additional_components": [ "Q54PS7", "DDB_G0284449", "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10710368": { "compartment": "compartment_12045", "id": "reaction_10710368", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680333": { "compartment": "compartment_70101", "id": "reaction_10680333", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_29356" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691952": { "compartment": "compartment_12045", "id": "reaction_10691952", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_426955", "species_111294" ], "modifiers": [ [ "species_10691949", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10691882": { "compartment": "compartment_12045", "id": "reaction_10691882", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_109395", "species_426639" ], "modifiers": [ [ "species_10691879", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29418", "species_29926" ] }, "reaction_10685601": { "compartment": "compartment_984", "id": "reaction_10685601", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10685598", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10711099": { "compartment": "compartment_70101", "id": "reaction_10711099", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10711096", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q55DN9", "DDB_G0276935" ] }, "reaction_10691727": { "compartment": "compartment_70616", "id": "reaction_10691727", "reactome": "R-DDI-1482759", "name": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_113521" ], "products": [ "species_1524085", "species_1498753" ], "modifiers": [ [ "species_10691724", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10693335": { "compartment": "compartment_171062", "id": "reaction_10693335", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_1806238", "species_29370" ], "modifiers": [ [ "species_10693095", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10693308": { "compartment": "compartment_876", "id": "reaction_10693308", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10693305", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10693296": { "compartment": "compartment_876", "id": "reaction_10693296", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693293", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10693282": { "compartment": "compartment_12045", "id": "reaction_10693282", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806234", "species_29356" ], "products": [ "species_426639", "species_29372" ], "modifiers": [ [ "species_10693279", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10693291": { "compartment": "compartment_171062", "id": "reaction_10693291", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_1806199", "species_29372" ], "modifiers": [ [ "species_10693247", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691965": { "compartment": "compartment_12045", "id": "reaction_10691965", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_71284" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10691962", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10722158": { "compartment": "compartment_984", "id": "reaction_10722158", "reactome": "R-DDI-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2173763", "species_109276" ], "products": [ "species_8952253", "species_8954142" ], "modifiers": [ [ "species_10722155", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10693313": { "compartment": "compartment_876", "id": "reaction_10693313", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691699": { "compartment": "compartment_70101", "id": "reaction_10691699", "reactome": "R-DDI-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10691663", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10691732": { "compartment": "compartment_12045", "id": "reaction_10691732", "reactome": "R-DDI-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500646", "species_29356" ], "products": [ "species_1498724", "species_1524021" ], "modifiers": [ [ "species_10691729", "catalyst" ] ], "additional_components": [ "species_74016", "Q54CM2", "DDB_G0292858" ] }, "reaction_10720416": { "compartment": "compartment_876", "id": "reaction_10720416", "reactome": "R-DDI-8870489", "name": "PLEKHA4,(5,6) bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720412", "species_1806276" ], "products": [ "species_10720414" ], "modifiers": [], "additional_components": [ "Q54Z52", "DDB_G0277777", "Q54Z52", "DDB_G0277777", "species_1806159" ] }, "reaction_10693003": { "compartment": "compartment_876", "id": "reaction_10693003", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10693000", "catalyst" ] ], "additional_components": [ "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10719120": { "compartment": "compartment_70101", "id": "reaction_10719120", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_426639" ], "products": [ "species_426658", "species_426755" ], "modifiers": [ [ "species_10719117", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q55DN9", "DDB_G0276935" ] }, "reaction_10693228": { "compartment": "compartment_876", "id": "reaction_10693228", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10693225", "catalyst" ] ], "additional_components": [ "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54D97", "DDB_G0292392", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691640": { "compartment": "compartment_12045", "id": "reaction_10691640", "reactome": "R-DDI-1482545", "name": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_29356" ], "products": [ "species_1524023", "species_1524021" ], "modifiers": [ [ "species_10691637", "catalyst" ] ], "additional_components": [ "DDB_G0292858" ] }, "reaction_10715942": { "compartment": "compartment_70101", "id": "reaction_10715942", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715938" ], "products": [ "species_10715940" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10682763": { "compartment": "compartment_984", "id": "reaction_10682763", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10682758", "catalyst" ], [ "species_10682761", "inhibitor" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10693239": { "compartment": "compartment_876", "id": "reaction_10693239", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10693236", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10702080": { "compartment": "compartment_876", "id": "reaction_10702080", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702076", "species_171142" ], "products": [ "species_10702078" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q86K21", "DDB_G0272875", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791", "Q86K21", "DDB_G0272875", "species_171142", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q1ZXB3", "DDB_G0291498", "Q55GG1", "DDB_G0267688", "Q54P51", "DDB_G0284791" ] }, "reaction_10715875": { "compartment": "compartment_876", "id": "reaction_10715875", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_426658", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10715909": { "compartment": "compartment_70101", "id": "reaction_10715909", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692916", "species_10715901" ], "products": [ "species_10715907" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693299": { "compartment": "compartment_876", "id": "reaction_10693299", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_202247", "species_29356" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10680330", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10691942": { "compartment": "compartment_12045", "id": "reaction_10691942", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_200736" ], "products": [ "species_1500646", "species_1498751" ], "modifiers": [ [ "species_10691939", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10692973": { "compartment": "compartment_172574", "id": "reaction_10692973", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_1806195", "species_29372" ], "modifiers": [ [ "species_10692970", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691720": { "compartment": "compartment_70616", "id": "reaction_10691720", "reactome": "R-DDI-1482745", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_113521" ], "products": [ "species_1524085", "species_1524027" ], "modifiers": [ [ "species_10691717", "catalyst" ] ], "additional_components": [ "Q54CM2", "DDB_G0292858" ] }, "reaction_10715855": { "compartment": "compartment_70101", "id": "reaction_10715855", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715851", "species_10715825" ], "products": [ "species_10715853" ], "modifiers": [], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10691635": { "compartment": "compartment_12045", "id": "reaction_10691635", "reactome": "R-DDI-1482543", "name": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_29356" ], "products": [ "species_76116", "species_1500593" ], "modifiers": [ [ "species_10691632", "catalyst" ] ], "additional_components": [ "Q55EQ3", "DDB_G0269086" ] }, "reaction_10721177": { "compartment": "compartment_984", "id": "reaction_10721177", "reactome": "R-DDI-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878780", "species_109276" ], "products": [ "species_109277", "species_8878776" ], "modifiers": [ [ "species_10721174", "catalyst" ] ], "additional_components": [ "species_29426", "species_74016", "Q54Y02", "DDB_G0278495" ] }, "reaction_10691702": { "compartment": "compartment_12045", "id": "reaction_10691702", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498738", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10691694", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541" ] }, "reaction_10692986": { "compartment": "compartment_12045", "id": "reaction_10692986", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10692983", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10692049": { "compartment": "compartment_12045", "id": "reaction_10692049", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692028" ], "products": [ "species_10691930" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10693269": { "compartment": "compartment_876", "id": "reaction_10693269", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10693266", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "species_74016", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "species_29418", "species_29926", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10715872": { "compartment": "compartment_876", "id": "reaction_10715872", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806224", "species_29356" ], "products": [ "species_1806240", "species_29372" ], "modifiers": [ [ "species_10715869", "catalyst" ] ], "additional_components": [ "Q55EE1", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10693230": { "compartment": "compartment_172574", "id": "reaction_10693230", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_29370", "species_1806198" ], "modifiers": [ [ "species_10693120", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54676", "DDB_G0289601", "P54675", "DDB_G0275011", "species_74016", "Q54S77", "DDB_G0282627", "Q54S78", "DDB_G0282625", "species_29926", "P54674", "DDB_G0283081", "species_29418", "Q55FX5", "DDB_G0282625" ] }, "reaction_10718631": { "compartment": "compartment_984", "id": "reaction_10718631", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_83910", "species_8865629" ], "modifiers": [ [ "species_10718628", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10679264": { "compartment": "compartment_5460", "id": "reaction_10679264", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_188451", "species_31649" ], "modifiers": [ [ "species_10679261", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10697686": { "compartment": "compartment_1598585", "id": "reaction_10697686", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10697678", "species_10697638" ], "products": [ "species_10697684" ], "modifiers": [], "additional_components": [ "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54S35", "DDB_G0282689", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q54RK7", "DDB_G0283099", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101" ] }, "reaction_10724623": { "compartment": "compartment_984", "id": "reaction_10724623", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10709857", "catalyst" ] ], "additional_components": [ "LigandDisplayForward?ligandId=6571", "LigandDisplayForward?ligandId=6453", "LigandDisplayForward?ligandId=6459", "LigandDisplayForward?ligandId=6462", "LigandDisplayForward?ligandId=6322", "pubchem.compound:443874", "LigandDisplayForward?ligandId=6575", "LigandDisplayForward?ligandId=6456", "LigandDisplayForward?ligandId=6374", "LigandDisplayForward?ligandId=6350", "LigandDisplayForward?ligandId=6377", "LigandDisplayForward?ligandId=6339", "LigandDisplayForward?ligandId=6367", "LigandDisplayForward?ligandId=6378", "LigandDisplayForward?ligandId=6576", "pubchem.compound:443151", "LigandDisplayForward?ligandId=6572", "LigandDisplayForward?ligandId=6352", "LigandDisplayForward?ligandId=6463", "LigandDisplayForward?ligandId=6455", "LigandDisplayForward?ligandId=6332", "LigandDisplayForward?ligandId=6461", "LigandDisplayForward?ligandId=6375", "LigandDisplayForward?ligandId=6344", "LigandDisplayForward?ligandId=6373", "LigandDisplayForward?ligandId=6457", "Q54ET7", "DDB_G0291344" ] }, "reaction_10675685": { "compartment": "compartment_7660", "id": "reaction_10675685", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675681", "species_10675662" ], "products": [ "species_10675683" ], "modifiers": [], "additional_components": [ "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003" ] }, "reaction_10675664": { "compartment": "compartment_7660", "id": "reaction_10675664", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675648", "species_10675660" ], "products": [ "species_10675662" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10675689": { "compartment": "compartment_7660", "id": "reaction_10675689", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675683" ], "products": [ "species_10675681", "species_10675687" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54RX0", "DDB_G0282863", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q75J91", "DDB_G0288225", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q54RX0", "DDB_G0282863", "C7G054", "DDB_G0302414", "Q55A45", "DDB_G0272320", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q86L45", "DDB_G0273003", "Q55D17", "DDB_G0269814", "Q54J82", "DDB_G0288225", "Q54KR9", "DDB_G0287197", "Q75J91", "DDB_G0288225" ] }, "reaction_10682234": { "compartment": "compartment_70101", "id": "reaction_10682234", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10682231", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10696143": { "compartment": "compartment_70101", "id": "reaction_10696143", "reactome": "R-DDI-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10696140", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "species_29450" ] }, "reaction_10679144": { "compartment": "compartment_5460", "id": "reaction_10679144", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_177153", "species_113593" ], "products": [ "species_159448", "species_177137", "species_159450" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677098": { "compartment": "compartment_5460", "id": "reaction_10677098", "reactome": "R-DDI-159567", "name": "ACSM2B-like proteins transform ST to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159559", "species_113593" ], "products": [ "species_159448", "species_159557", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10677081": { "compartment": "compartment_5460", "id": "reaction_10677081", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_159446", "species_113593" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10677078", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10723456": { "compartment": "compartment_70101", "id": "reaction_10723456", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723452", "species_10676533" ], "products": [ "species_10723454" ], "modifiers": [], "additional_components": [ "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q6UK63", "DDB_G0287855", "Q54Q49", "DDB_G0284155", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "species_29438", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "P36411", "DDB_G0269236", "Q869N2", "DDB_G0276459" ] }, "reaction_10703564": { "compartment": "compartment_876", "id": "reaction_10703564", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703557" ], "products": [ "species_10703559" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10726069": { "compartment": "compartment_876", "id": "reaction_10726069", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726067" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10726063": { "compartment": "compartment_876", "id": "reaction_10726063", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10726050" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10703562": { "compartment": "compartment_70101", "id": "reaction_10703562", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703559", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10723450": { "compartment": "compartment_70101", "id": "reaction_10723450", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723366", "species_10723444" ], "products": [ "species_10723448" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723813": { "compartment": "compartment_876", "id": "reaction_10723813", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723796", "species_10723809" ], "products": [ "species_10723811" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q55CB3", "DDB_G0290593", "Q86KL1", "DDB_G0274241", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q54LT3", "DDB_G0286425", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q54FU0", "DDB_G0290593", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "B0G0Y8", "DDB_G0268634", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54QX3", "DDB_G0283587", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q54B82", "DDB_G0293844", "P34144", "DDB_G0277869", "P34146", "DDB_G0282365", "Q54XF1", "DDB_G0279003", "Q557J6", "DDB_G0273447", "Q86KL1", "DDB_G0274241", "species_29438", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "Q54HL6", "DDB_G0289361", "Q54ER7", "DDB_G0291225", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593" ] }, "reaction_10723162": { "compartment": "compartment_876", "id": "reaction_10723162", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10723159", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54LN3", "DDB_G0286543", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54PB7", "DDB_G0292004", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q86I66", "DDB_G0293084", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54DS6", "DDB_G0291974", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q86HN1", "DDB_G0293396", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q55BQ8", "DDB_G0292004", "Q54S15", "DDB_G0293396", "P34043", "DDB_G0286185", "Q8SSQ3", "DDB_G0274607", "Q54DW4", "DDB_G0291978", "Q54FF3", "DDB_G0290901", "P34042", "DDB_G0285425", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q8IS16", "DDB_G0276963", "Q55EI2", "DDB_G0293084", "Q54L90", "DDB_G0286773", "Q55G61", "DDB_G0268354", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q54DW1", "DDB_G0292004", "P34044", "DDB_G0283151", "Q55FD8", "DDB_G0268578", "Q1ZX99", "DDB_G0293928", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q55EP5", "DDB_G0268802", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10725982": { "compartment": "compartment_263163", "id": "reaction_10725982", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725978", "species_10725976" ], "products": [ "species_10725980" ], "modifiers": [], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q8T2F2", "DDB_G0277439", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "P36411", "DDB_G0269236", "Q1ZXI1", "DDB_G0279085", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54NZ5", "DDB_G0284903", "Q54FK7", "DDB_G0290779", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "Q54FK8", "DDB_G0290829", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q1ZXB9", "DDB_G0290831", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "P34145", "DDB_G0268622", "Q1ZXI1", "DDB_G0279085", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P34146", "DDB_G0282365", "Q8T2F2", "DDB_G0277439", "Q54K69", "DDB_G0287553", "Q9GPR7", "DDB_G0269240", "Q54FK2", "DDB_G0290793", "Q9GPS3", "DDB_G0276967", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "P34149", "DDB_G0293526", "Q54FK5", "DDB_G0290789", "species_113592", "Q54NZ5", "DDB_G0284903", "Q23862", "DDB_G0280975" ] }, "reaction_10723744": { "compartment": "compartment_876", "id": "reaction_10723744", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723740", "species_10723682" ], "products": [ "species_10723742" ], "modifiers": [], "additional_components": [ "Q55CB2", "DDB_G0290593", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q54P92", "DDB_G0284699", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "Q54TA6", "DDB_G0281889", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55D99", "DDB_G0269166", "Q54I58", "DDB_G0288989", "Q55CB3", "DDB_G0290593", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q54P92", "DDB_G0284699", "P34150", "DDB_G0291976", "Q8MPQ7", "DDB_G0280053", "Q54N82", "DDB_G0285453", "Q86HL8", "DDB_G0274517", "P34145", "DDB_G0268622", "Q55CR3", "DDB_G0269938", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54BQ5", "DDB_G0293498", "Q54TR7", "DDB_G0281797", "Q86HV4", "DDB_G0276427", "Q55GV3", "DDB_G0267450", "Q54HZ4", "DDB_G0289123", "Q55CR2", "DDB_G0269940", "P34146", "DDB_G0282365", "Q557J6", "DDB_G0273447", "Q55DD4", "DDB_G0269696", "P32255", "DDB_G0287689", "Q86KG4", "DDB_G0272498", "Q54K65", "DDB_G0290995", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q54TA6", "DDB_G0281889", "P34148", "DDB_G0279605", "P36411", "DDB_G0269236", "Q54EF5", "DDB_G0291562", "P34149", "DDB_G0293526", "Q54NM4", "DDB_G0285141", "P90532", "DDB_G0288065", "Q54P30", "DDB_G0284825", "Q8T158", "DDB_G0274247", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q869N2", "DDB_G0276459" ] }, "reaction_10723589": { "compartment": "compartment_876", "id": "reaction_10723589", "reactome": "R-DDI-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723581" ], "products": [ "species_10723579", "species_29420" ], "modifiers": [ [ "species_10689591", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084" ] }, "reaction_10702646": { "compartment": "compartment_876", "id": "reaction_10702646", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10680761" ], "products": [ "species_10702641" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10725989": { "compartment": "compartment_263163", "id": "reaction_10725989", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725976", "species_29356" ], "products": [ "species_10725986", "species_29372" ], "modifiers": [ [ "species_10725976", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "species_29370", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10726061": { "compartment": "compartment_17906", "id": "reaction_10726061", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726050", "species_10726057" ], "products": [ "species_10726059" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "Q55DS3", "DDB_G0269550", "Q55DS3", "DDB_G0269550", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10702637": { "compartment": "compartment_70101", "id": "reaction_10702637", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10702633" ], "products": [ "species_10702635" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723890": { "compartment": "compartment_876", "id": "reaction_10723890", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10723880" ], "products": [ "species_10723878", "species_29372" ], "modifiers": [ [ "species_10723887", "catalyst" ] ], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "species_29420", "P34147", "DDB_G0286555", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q8I7P3", "DDB_G0267462", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q54FG5", "DDB_G0290873", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10723688": { "compartment": "compartment_876", "id": "reaction_10723688", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723680", "species_29438" ], "products": [ "species_10723682" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723759": { "compartment": "compartment_876", "id": "reaction_10723759", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723748", "species_10723755" ], "products": [ "species_10723757" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q54V78", "DDB_G0349530", "C7G034", "DDB_G0285063", "Q54K32", "DDB_G0287585", "species_29438", "Q54KI4", "DDB_G0287325", "Q9GPS0", "DDB_G0269178", "Q54DT4", "DDB_G0292046", "Q75JM6", "DDB_G0276057", "Q54QF1", "DDB_G0283983", "P25870", "DDB_G0277221", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10712144": { "compartment": "compartment_1222693", "id": "reaction_10712144", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_29370", "species_1629751" ], "modifiers": [ [ "species_10712141", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10722712": { "compartment": "compartment_70101", "id": "reaction_10722712", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683656" ], "products": [ "species_10683654", "species_10702660" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450" ] }, "reaction_10726075": { "compartment": "compartment_876", "id": "reaction_10726075", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723880" ], "products": [ "species_10726073" ], "modifiers": [], "additional_components": [ "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10723466": { "compartment": "compartment_70101", "id": "reaction_10723466", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723444" ], "products": [ "species_10676533", "species_29420" ], "modifiers": [ [ "species_10723463", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084", "Q54LN3", "DDB_G0286543", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10674723": { "compartment": "compartment_70101", "id": "reaction_10674723", "reactome": "R-DDI-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674719", "species_10674690" ], "products": [ "species_10674721" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "DDB_G0283617", "P54632", "DDB_G0269138", "Q54QM6", "DDB_G0283617" ] }, "reaction_10723374": { "compartment": "compartment_876", "id": "reaction_10723374", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723370", "species_10695507" ], "products": [ "species_10723372" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "species_29420", "P34144", "DDB_G0277869", "species_29420", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34144", "DDB_G0277869" ] }, "reaction_10723874": { "compartment": "compartment_876", "id": "reaction_10723874", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723872" ], "products": [ "species_10723864", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438" ] }, "reaction_10703581": { "compartment": "compartment_70101", "id": "reaction_10703581", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10703572" ], "products": [ "species_29370", "species_10703578" ], "modifiers": [ [ "species_10702680", "catalyst" ] ], "additional_components": [ "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "P13833", "DDB_G0276077", "P09402", "DDB_G0277859", "P08799", "DDB_G0286355", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10703534": { "compartment": "compartment_876", "id": "reaction_10703534", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10703530" ], "products": [ "species_10703532" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10725984": { "compartment": "compartment_263163", "id": "reaction_10725984", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10725974" ], "products": [ "species_10725976" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "species_113592", "Q23862", "DDB_G0280975" ] }, "reaction_10723906": { "compartment": "compartment_876", "id": "reaction_10723906", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723902", "species_10723880" ], "products": [ "species_10723904" ], "modifiers": [], "additional_components": [ "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "P34147", "DDB_G0286555", "species_29438", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "P34147", "DDB_G0286555", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q8IS18", "DDB_G0269252", "Q86JN1", "DDB_G0272062", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q55DD4", "DDB_G0269696", "Q54PM1", "DDB_G0284461", "species_29438", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10723586": { "compartment": "compartment_876", "id": "reaction_10723586", "reactome": "R-DDI-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723579", "species_29356" ], "products": [ "species_10723581", "species_29372" ], "modifiers": [ [ "species_10723583", "catalyst" ] ], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "species_29438", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "species_29420", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q8I7P3", "DDB_G0267462", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10726106": { "compartment": "compartment_876", "id": "reaction_10726106", "reactome": "R-DDI-9726862", "name": "Phosphorylated RHOU translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726100" ], "products": [ "species_10726104" ], "modifiers": [], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723461": { "compartment": "compartment_70101", "id": "reaction_10723461", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533", "species_29356" ], "products": [ "species_10723444", "species_29372" ], "modifiers": [ [ "species_10723458", "catalyst" ] ], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29420", "Q9GPQ8", "DDB_G0292816", "Q54ND2", "DDB_G0285391", "Q8SSN9", "DDB_G0274243", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q54J98", "DDB_G0288205", "Q54FF4", "DDB_G0290891" ] }, "reaction_10723354": { "compartment": "compartment_876", "id": "reaction_10723354", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_10723350" ], "products": [ "species_10723352" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459", "Q54WW0", "DDB_G0290421", "Q55D99", "DDB_G0269166", "Q54JR7", "DDB_G0287833", "Q54LN3", "DDB_G0286543", "Q55GN5", "DDB_G0267590", "Q54F44", "DDB_G0291117", "Q9GPS0", "DDB_G0269178", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54G40", "DDB_G0290421", "Q6UK63", "DDB_G0287855", "Q55FT9", "DDB_G0267956", "Q1ZXA8", "DDB_G0292160", "Q54X65", "DDB_G0279175", "P34144", "DDB_G0277869", "Q54GB3", "DDB_G0290363", "Q54WR4", "DDB_G0279483", "Q54I34", "DDB_G0289033", "Q55GV3", "DDB_G0267450", "Q556S2", "DDB_G0273121", "Q54UK0", "DDB_G0281031", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54PM1", "DDB_G0284461", "Q86GL4", "DDB_G0287101", "species_29438", "Q54NF8", "DDB_G0285253", "O00899", "DDB_G0269140", "Q869Q3", "DDB_G0274519", "Q86IX1", "DDB_G0274593", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "P36411", "DDB_G0269236", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q869N2", "DDB_G0276459" ] }, "reaction_10702689": { "compartment": "compartment_70101", "id": "reaction_10702689", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702662", "species_113592" ], "products": [ "species_29370", "species_10683624", "species_10702686" ], "modifiers": [ [ "species_10702662", "catalyst" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723870": { "compartment": "compartment_876", "id": "reaction_10723870", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723864", "species_10723866" ], "products": [ "species_10723868" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "species_29438", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q54BF1", "DDB_G0293654", "Q54V78", "DDB_G0349530", "Q86HG9", "DDB_G0278535", "Q54PG5", "DDB_G0284571", "Q9GPS0", "DDB_G0269178", "Q54HC6", "DDB_G0289555", "Q54DT4", "DDB_G0292046", "Q54TM7", "DDB_G0281557", "Q54MV3", "DDB_G0285641", "Q86I31", "DDB_G0275085", "Q54SL6", "DDB_G0282395", "Q55GV3", "DDB_G0267450", "Q86IG9", "DDB_G0272694", "Q553T4", "DDB_G0292046", "P05095", "DDB_G0268632", "Q86B03", "DDB_G0276833", "Q55DD4", "DDB_G0269696", "Q54K32", "DDB_G0287585", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "species_29438", "Q553X3", "DDB_G0275185", "Q54XX5", "DDB_G0278535", "Q75JM6", "DDB_G0276057", "P25870", "DDB_G0277221", "Q54FG5", "DDB_G0290873", "Q54Q34", "DDB_G0349530", "Q869N2", "DDB_G0276459" ] }, "reaction_10702643": { "compartment": "compartment_70101", "id": "reaction_10702643", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702635", "species_10693765" ], "products": [ "species_10702639" ], "modifiers": [ [ "species_10702641", "inhibitor" ] ], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q54K32", "DDB_G0287585", "Q554S6", "DDB_G0274131", "Q54JL1", "DDB_G0287981", "species_29438", "O00899", "DDB_G0269140", "Q54HF1", "DDB_G0289505", "Q9GPS0", "DDB_G0269178", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "P34144", "DDB_G0277869", "species_113592", "Q55EU6", "DDB_G0268744", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q54I34", "DDB_G0289033", "P02599", "DDB_G0279407", "Q9GPS0", "DDB_G0269178", "O00897", "DDB_G0269104", "species_74016", "P34144", "DDB_G0277869", "Q54K32", "DDB_G0287585", "Q7Z2B8", "DDB_G0277917", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033" ] }, "reaction_10723898": { "compartment": "compartment_876", "id": "reaction_10723898", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_10723892" ], "products": [ "species_10723896" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "Q95UQ1", "DDB_G0291077", "species_29420", "Q95UQ1", "DDB_G0291077", "P34147", "DDB_G0286555" ] }, "reaction_10723798": { "compartment": "compartment_74700", "id": "reaction_10723798", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723794" ], "products": [ "species_10723796" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10703537": { "compartment": "compartment_70101", "id": "reaction_10703537", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10703532", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "species_29438", "Q86GL4", "DDB_G0287101" ] }, "reaction_10723885": { "compartment": "compartment_876", "id": "reaction_10723885", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723878", "species_29438" ], "products": [ "species_10723880", "species_29420" ], "modifiers": [ [ "species_10723882", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q54SG9", "DDB_G0282475", "Q554I8", "DDB_G0293084" ] }, "reaction_10723290": { "compartment": "compartment_876", "id": "reaction_10723290", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526", "species_29356" ], "products": [ "species_29372", "species_10695507" ], "modifiers": [ [ "species_10723287", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54ND2", "DDB_G0285391", "Q86B03", "DDB_G0276833", "Q54BF1", "DDB_G0293654", "Q54XE8", "DDB_G0279009", "Q54E35", "DDB_G0291840", "Q54XT6", "DDB_G0278755", "Q54BP9", "DDB_G0293510", "Q553X3", "DDB_G0275185", "Q54FF4", "DDB_G0290891", "Q54PG5", "DDB_G0284571", "Q8SSN9", "DDB_G0274243", "Q54MV3", "DDB_G0285641", "Q55DW9", "DDB_G0269496", "Q54TH9", "DDB_G0281739", "Q54FG5", "DDB_G0290873", "Q1ZXE1", "DDB_G0287895", "Q86I31", "DDB_G0275085", "Q54J98", "DDB_G0288205", "Q54SL6", "DDB_G0282395", "Q86IG9", "DDB_G0272694" ] }, "reaction_10725875": { "compartment": "compartment_876", "id": "reaction_10725875", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676526" ], "products": [ "species_10725873" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10722714": { "compartment": "compartment_70101", "id": "reaction_10722714", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683652" ], "products": [ "species_10683650", "species_10702658" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10723764": { "compartment": "compartment_876", "id": "reaction_10723764", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10723761" ], "products": [ "species_10723748", "species_29420" ], "modifiers": [ [ "species_10723761", "catalyst" ] ], "additional_components": [ "species_29420", "Q9GPS0", "DDB_G0269178", "Q9GPS0", "DDB_G0269178", "species_29438", "species_29420", "Q9GPS0", "DDB_G0269178" ] }, "reaction_10723468": { "compartment": "compartment_876", "id": "reaction_10723468", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676533" ], "products": [ "species_10703511" ], "modifiers": [], "additional_components": [ "species_29438", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q9GPQ8", "DDB_G0292816" ] }, "reaction_10723686": { "compartment": "compartment_876", "id": "reaction_10723686", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723403", "species_10723682" ], "products": [ "species_10723684" ], "modifiers": [], "additional_components": [ "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q95UQ1", "DDB_G0291077", "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "Q95UP9", "DDB_G0280049", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975" ] }, "reaction_10723860": { "compartment": "compartment_74700", "id": "reaction_10723860", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723845", "species_10723856" ], "products": [ "species_10723858" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "P34150", "DDB_G0291976", "P34148", "DDB_G0279605", "Q54N82", "DDB_G0285453", "P34149", "DDB_G0293526", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "Q23862", "DDB_G0280975", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q54Y26", "DDB_G0278457", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q869T1", "DDB_G0274437", "Q54HF1", "DDB_G0289505", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530", "Q55CB2", "DDB_G0290593", "Q54HE7", "DDB_G0289511", "Q9GPQ9", "DDB_G0292560", "Q54YY4", "DDB_G0278009", "Q55CB3", "DDB_G0290593", "Q54ES9", "DDB_G0291358", "Q54GX7", "DDB_G0289811", "Q54V78", "DDB_G0349530", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "P34150", "DDB_G0291976", "Q54N82", "DDB_G0285453", "Q54Y26", "DDB_G0278457", "P34145", "DDB_G0268622", "Q553U6", "DDB_G0275023", "Q54MP8", "DDB_G0285837", "P34144", "DDB_G0277869", "Q55EU6", "DDB_G0268744", "P07829", "DDB_G0289487", "P34146", "DDB_G0282365", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q76NU3", "DDB_G0277493", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "species_29438", "Q54JL1", "DDB_G0287981", "Q54LT3", "DDB_G0286425", "Q9GPR7", "DDB_G0269240", "Q9GPS3", "DDB_G0276967", "Q869T1", "DDB_G0274437", "P34148", "DDB_G0279605", "Q54HF1", "DDB_G0289505", "P34149", "DDB_G0293526", "Q54ER7", "DDB_G0291225", "Q55CU2", "DDB_G0269902", "Q75JM6", "DDB_G0276057", "Q54NZ5", "DDB_G0284903", "Q55CR6", "DDB_G0269932", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "Q23862", "DDB_G0280975", "Q54FU0", "DDB_G0290593", "Q54Q34", "DDB_G0349530" ] }, "reaction_10682167": { "compartment": "compartment_13231", "id": "reaction_10682167", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682163" ], "products": [ "species_10682165" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10682358": { "compartment": "compartment_7660", "id": "reaction_10682358", "reactome": "R-DDI-349444", "name": "Phosphorylation of COP1 at Ser-387 by ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10682348" ], "products": [ "species_113582", "species_10682163" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0288453", "DDB_G0288453", "DDB_G0275845" ] }, "reaction_10682172": { "compartment": "compartment_70101", "id": "reaction_10682172", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10682165" ], "products": [ "species_10682169" ], "modifiers": [ [ "species_10682165", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0288453" ] }, "reaction_10682174": { "compartment": "compartment_70101", "id": "reaction_10682174", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682169" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10684699": { "compartment": "compartment_7660", "id": "reaction_10684699", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684682", "species_427523" ], "products": [ "species_427498", "species_427497", "species_10682100" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10684702": { "compartment": "compartment_7660", "id": "reaction_10684702", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10682100" ], "products": [ "species_10674676", "species_77502" ], "modifiers": [ [ "species_10684696", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54GV7", "DDB_G0289967", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863" ] }, "reaction_10689258": { "compartment": "compartment_70101", "id": "reaction_10689258", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10689251" ], "products": [ "species_10689255", "species_10689247", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689128", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54YW2", "DDB_G0278049", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q54FX4", "DDB_G0290547", "Q550Z9", "DDB_G0276695", "Q54LZ6", "DDB_G0286289", "Q94490", "DDB_G0284865", "Q55EJ5", "DDB_G0270000", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54XF1", "DDB_G0279003", "Q54L05", "DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", 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"DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q54MZ3", "DDB_G0285601", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q557I6", "DDB_G0273399", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q75JS0", "DDB_G0272202", "Q557E7", "DDB_G0273141", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249" ] }, "reaction_10689274": { "compartment": "compartment_70101", "id": "reaction_10689274", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10670153", "species_983032", "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689362": { "compartment": "compartment_70101", "id": "reaction_10689362", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10689359", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10721580": { "compartment": "compartment_70101", "id": "reaction_10721580", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10721577", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10681335": { "compartment": "compartment_12045", "id": "reaction_10681335", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681331" ], "products": [ "species_10681333" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29438", "Q559R0", "DDB_G0272296" ] }, "reaction_10689306": { "compartment": "compartment_70101", "id": "reaction_10689306", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_29926", "species_10689298" ], "products": [ "species_10689300", "species_111294", "species_76577", "species_29926" ], "modifiers": [ [ "species_10689298", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047" ] }, "reaction_10689303": { "compartment": "compartment_70101", "id": "reaction_10689303", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689300", "species_10689247" ], "products": [ "species_10689249", "species_10689298" ], "modifiers": [ [ "species_10689247", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "P0CG80", "DDB_G0291928", "Q86CR9", "DDB_G0271096", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54QG9", "DDB_G0283891", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q86CR9", "DDB_G0271096", "Q54C02", "DDB_G0293306", "Q55C16", "DDB_G0270272", "Q54QG9", "DDB_G0283891", "Q550P6", "DDB_G0277047", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345" ] }, "reaction_10689341": { "compartment": "compartment_17957", "id": "reaction_10689341", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_983033", "species_8943716" ], "modifiers": [ [ "species_10689338", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10689309": { "compartment": "compartment_70101", "id": "reaction_10689309", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689255", "species_113592" ], "products": [ "species_10689247", "species_10689270", "species_111294", "species_76577" ], "modifiers": [ [ "species_10689255", "catalyst" ] ], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689249", "species_10689128", "species_983035" ], "products": [ "species_10689251" ], "modifiers": [], "additional_components": [ "Q54FR5", "DDB_G0290629", "Q54TI6", "DDB_G0281725", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54U33", "DDB_G0281369", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55EY8", "DDB_G0268938", "Q54TK0", "DDB_G0281703", "Q55C16", "DDB_G0270272", "Q54VG3", "DDB_G0280347", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "Q54D06", "DDB_G0292596", "Q555G0", "DDB_G0274897", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "P0CG80", "DDB_G0291928", "O76542", "DDB_G0284009", "P0CG79", 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"DDB_G0286991", "Q86K32", "DDB_G0277267", "Q551S9", "DDB_G0276377", "P0CG88", "DDB_G0269458", "Q54J12", "DDB_G0290547", "Q54NI1", "DDB_G0285223", "O76542", "DDB_G0284009", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54E43", "DDB_G0291812", "Q54TE1", "DDB_G0290629", "Q54JT8", "DDB_G0292128", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q55ER5", "DDB_G0268992", "Q54DM4", "DDB_G0292128", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q55C16", "DDB_G0270272", "Q557I6", "DDB_G0273399", "Q54D06", "DDB_G0292596", "Q54LP7", "DDB_G0286511", "Q54XS6", "DDB_G0278775", "Q54N86", "DDB_G0285445", "Q86J11", "DDB_G0274267", "Q54F86", "DDB_G0291011", "Q54DL2", "DDB_G0292144", "P0CG80", "DDB_G0291928", "C7FZX3", "DDB_G0295761", "Q54N05", "DDB_G0285581", "Q54KP2", "DDB_G0287221", "Q75JS0", "DDB_G0272202", "P14794", "DDB_G0280755", "Q54X83", "DDB_G0279139", "Q86K42", "DDB_G0277249", "Q553F3", "DDB_G0275787", "Q557Q0", "DDB_G0291812", "Q75JE1", "DDB_G0288345", "Q54XF7", "DDB_G0278991", "Q54TL7", "DDB_G0281679", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54JV0", "DDB_G0292128", "Q54I43", "DDB_G0289021", "Q54I29", "DDB_G0292642", "Q54IK3", "DDB_G0290547", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54RP0", "DDB_G0283005", "Q54VG3", "DDB_G0280347", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q54VW9", "DDB_G0280091", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "P0CG79", "DDB_G0282369", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "P0CG78", "DDB_G0289449", "Q54D58", "DDB_G0292470", "P14797", "DDB_G0276765", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54U33", "DDB_G0281369", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "P0CG77", "DDB_G0286907", "Q55EY8", "DDB_G0268938", "Q1ZXE6", "DDB_G0286233", "Q54EF6", "DDB_G0291612", "Q54TK0", "DDB_G0281703", "Q54MZ3", "DDB_G0285601", "Q555G0", "DDB_G0274897", "Q54PV3", "DDB_G0292642", "Q557E4", "DDB_G0273251", "C7G038", "DDB_G0291812", "Q54F90", "DDB_G0291003", "Q557E7", "DDB_G0273141", "Q54J27", "DDB_G0288345" ] }, "reaction_10689272": { "compartment": "compartment_70101", "id": "reaction_10689272", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689270" ], "products": [ "species_983123", "species_10689128" ], "modifiers": [], "additional_components": [ "Q557Q0", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q75JM9", "DDB_G0292128", "Q54XF7", "DDB_G0278991", "Q54YW2", "DDB_G0278049", "Q54TL7", "DDB_G0281679", "Q54Q67", "DDB_G0284145", "Q9XZJ3", "DDB_G0267384", "Q550Z9", "DDB_G0276695", "Q54IL3", "DDB_G0292642", "Q54TM9", "DDB_G0281657", "Q54LZ6", "DDB_G0286289", "Q54JV0", "DDB_G0292128", "Q55EJ5", "DDB_G0270000", "Q54I29", "DDB_G0292642", "Q54QZ3", "DDB_G0292128", "Q54RA9", "DDB_G0283263", "Q54CX4", "DDB_G0292642", "Q54J83", "DDB_G0288223", "Q54QS0", "DDB_G0283667", "Q54XG4", "DDB_G0292642", "Q550K3", "DDB_G0277075", "Q54RP0", "DDB_G0283005", "Q54XF1", "DDB_G0279003", "Q8T2F2", "DDB_G0277439", "Q54DM8", "DDB_G0292120", "Q54L05", "DDB_G0286991", "Q551S9", "DDB_G0276377", "C7G034", "DDB_G0285063", "Q7KWS8", "DDB_G0276283", "Q54PM1", "DDB_G0284461", "Q54QG5", "DDB_G0283893", "Q55CM4", "DDB_G0270000", "Q54DF3", "DDB_G0292302", "Q54NI1", "DDB_G0285223", "Q54XA6", "DDB_G0279093", "Q54R25", "DDB_G0291011", "Q54L48", "DDB_G0286909", "P52285", "DDB_G0269230", "Q54NZ5", "DDB_G0284903", "Q55DC5", "DDB_G0269704", "Q54JE9", "DDB_G0292128", "Q54SL8", "DDB_G0282391", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54D84", "DDB_G0292436", "Q54UQ3", "DDB_G0280895", "Q54IW6", "DDB_G0292128", "Q86I15", "DDB_G0291011", "O44007", "DDB_G0292264", "Q557G6", "DDB_G0291812", "Q54D58", "DDB_G0292470", "Q54E43", "DDB_G0291812", "Q54NC6", "DDB_G0285349", "Q54LV9", "DDB_G0286387", "Q54K33", "DDB_G0287629", "Q6T486", "DDB_G0286961", "Q55BF8", "DDB_G0274267", "Q54JT8", "DDB_G0292128", "Q86AD8", "DDB_G0271500", "O60999", "DDB_G0291972", "Q1ZXI1", "DDB_G0279085", "Q54QF1", "DDB_G0283983", "Q555H8", "DDB_G0274875", "Q54Q05", "DDB_G0284201", "Q55GE4", "DDB_G0291812", "Q54VV5", "DDB_G0280113", "Q54C30", "DDB_G0293230", "Q1ZXE6", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_983036", "species_8942986" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10722775": { "compartment": "compartment_876", "id": "reaction_10722775", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722754" ], "products": [ "species_10722772", "species_29372" ], "modifiers": [ [ "species_10722754", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684253": { "compartment": "compartment_876", "id": "reaction_10684253", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141" ], "products": [ "species_10684218" ], "modifiers": [ [ "species_10676141", "catalyst" ], [ "species_10684251", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10676760": { "compartment": "compartment_70101", "id": "reaction_10676760", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676657", "species_114520" ], "products": [ "species_10676659" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74016", "Q9NA13", "DDB_G0292564" ] }, "reaction_10684674": { "compartment": "compartment_70101", "id": "reaction_10684674", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_29370", "species_76108" ], "modifiers": [ [ "species_10684665", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10722756": { "compartment": "compartment_876", "id": "reaction_10722756", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_10722752" ], "products": [ "species_10722754" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684660": { "compartment": "compartment_70101", "id": "reaction_10684660", "reactome": "R-DDI-426043", "name": "2-AG hydrolysis to arachidonate by MAGL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426030", "species_29356" ], "products": [ "species_70106", "species_76116", "species_422506" ], "modifiers": [ [ "species_10684657", "catalyst" ] ], "additional_components": [ "DDB_G0269086" ] }, "reaction_10722777": { "compartment": "compartment_876", "id": "reaction_10722777", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722772" ], "products": [ "species_10722752", "species_10684218" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q54LD1", "DDB_G0286817", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10684652": { "compartment": "compartment_876", "id": "reaction_10684652", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10684649", "catalyst" ] ], "additional_components": [ "Q54YL1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54ET1", "DDB_G0291354" ] }, "reaction_10676646": { "compartment": "compartment_876", "id": "reaction_10676646", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676641" ], "products": [ "species_10676643" ], "modifiers": [ [ "species_10676143", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736", "species_179856", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_114520", "P34044", "DDB_G0283151", "species_6797635", "species_29438", "Q02158", "DDB_G0292736", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10673792": { "compartment": "compartment_70101", "id": "reaction_10673792", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83960" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673796": { "compartment": "compartment_70101", "id": "reaction_10673796", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_73617" ], "products": [ "species_73619", "species_113528", "species_31633" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10674384": { "compartment": "compartment_70101", "id": "reaction_10674384", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_500244", "species_83962" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:16450", "species_112016", "CHEBI:58576", "Q54PM8", "DDB_G0284431" ] }, "reaction_10673794": { "compartment": "compartment_70101", "id": "reaction_10673794", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73541", "species_29356" ], "products": [ "species_70106", "species_73617" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10673760": { "compartment": "compartment_70101", "id": "reaction_10673760", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73588", "species_29356" ], "products": [ "species_113528", "species_31633", "species_73590" ], "modifiers": [ [ "species_10673757", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10673740": { "compartment": "compartment_70101", "id": "reaction_10673740", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_83962" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10673737", "catalyst" ] ], "additional_components": [ "species_76629", "Q55FT1", "DDB_G0267966", "species_113596" ] }, "reaction_10673750": { "compartment": "compartment_70101", "id": "reaction_10673750", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_70106", "species_73588" ], "modifiers": [ [ "species_10673747", "catalyst" ] ], "additional_components": [ "Q55DL0", "DDB_G0269246", "species_29426" ] }, "reaction_10675646": { "compartment": "compartment_5460", "id": "reaction_10675646", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10722311": { "compartment": "compartment_5460", "id": "reaction_10722311", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_77343", "species_113529" ], "products": [ "species_113563", "species_77308" ], "modifiers": [ [ "species_10722308", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10679923": { "compartment": "compartment_876", "id": "reaction_10679923", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679514", "species_10679534" ], "products": [ "species_10679536" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54HE7", "DDB_G0289511", "Q55DY5", "DDB_G0287981", "Q55DS6", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q94464", "DDB_G0277849", "P07830", "DDB_G0269234", "Q54HE9", "DDB_G0289533", "Q554S6", "DDB_G0274131", "P54672", "DDB_G0277139", "Q8MN58", "DDB_G0277403", "Q54JL1", "DDB_G0287981", "Q54HF1", "DDB_G0289505", "Q553U6", "DDB_G0275023", "Q55CU2", "DDB_G0269902", "Q55EU6", "DDB_G0268744", "P25870", "DDB_G0277221", "P07828", "DDB_G0289489", "Q54HF0", "DDB_G0289507", "P07829", "DDB_G0289487" ] }, "reaction_10669451": { "compartment": "compartment_7660", "id": "reaction_10669451", "reactome": "R-DDI-68595", "name": "ORC2 binds ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669447", "species_10669442" ], "products": [ "species_10669449" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10669460": { "compartment": "compartment_7660", "id": "reaction_10669460", "reactome": "R-DDI-68603", "name": "ORC5 binds ORC2:ORC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669449", "species_10669456" ], "products": [ "species_10669458" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078" ] }, "reaction_10726116": { "compartment": "compartment_70101", "id": "reaction_10726116", "reactome": "R-DDI-9734730", "name": "ORC1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10726114" ], "products": [ "species_10669474" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10669494": { "compartment": "compartment_7660", "id": "reaction_10669494", "reactome": "R-DDI-68615", "name": "Formation of ORC(1-6) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669482", "species_10669490" ], "products": [ "species_10669492" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "DDB_G0284771", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10726142": { "compartment": "compartment_7660", "id": "reaction_10726142", "reactome": "R-DDI-9749197", "name": "ORC1 binds to H4K20me2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669474", "species_10726138" ], "products": [ "species_10726140" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q54RM2", "DDB_G0283073", "Q76NW2", "DDB_G0276863" ] }, "reaction_10669469": { "compartment": "compartment_7660", "id": "reaction_10669469", "reactome": "R-DDI-68610", "name": "Formation of ORC(2-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669458", "species_10669465" ], "products": [ "species_10669467" ], "modifiers": [ [ "species_29358", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562" ] }, "reaction_10669484": { "compartment": "compartment_7660", "id": "reaction_10669484", "reactome": "R-DDI-68611", "name": "Formation of ORC(1-5) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669467", "species_10669478" ], "products": [ "species_10669482" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073" ] }, "reaction_10696023": { "compartment": "compartment_876", "id": "reaction_10696023", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10691230", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10709790": { "compartment": "compartment_984", "id": "reaction_10709790", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_2160848", "species_5693343" ], "modifiers": [ [ "species_10709787", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10702727": { "compartment": "compartment_70101", "id": "reaction_10702727", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10683107" ], "products": [ "species_10702725" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54WU6", "DDB_G0279427", "Q54MV2", "DDB_G0285643" ] }, "reaction_10714788": { "compartment": "compartment_70101", "id": "reaction_10714788", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714777", "species_10714784" ], "products": [ "species_10714786" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10711995": { "compartment": "compartment_7660", "id": "reaction_10711995", "reactome": "R-DDI-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676302", "species_10711991" ], "products": [ "species_10711993" ], "modifiers": [], "additional_components": [ "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10714779": { "compartment": "compartment_876", "id": "reaction_10714779", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714775", "species_10714770" ], "products": [ "species_10714777" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10683116": { "compartment": "compartment_70101", "id": "reaction_10683116", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526" ], "products": [ "species_10683113", "species_29372" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q550Q4", "DDB_G0277041", "Q54D08", "DDB_G0292592", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10711979": { "compartment": "compartment_70101", "id": "reaction_10711979", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711969", "species_113592" ], "products": [ "species_29370", "species_10711977" ], "modifiers": [ [ "species_10680163", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10714366": { "compartment": "compartment_70101", "id": "reaction_10714366", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6799725" ], "products": [ "species_29366", "species_6799726" ], "modifiers": [ [ "species_10714301", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10714807": { "compartment": "compartment_17906", "id": "reaction_10714807", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10714802", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10712027": { "compartment": "compartment_7660", "id": "reaction_10712027", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10712011" ], "products": [ "species_113582", "species_10712024" ], "modifiers": [ [ "species_10712011", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714862": { "compartment": "compartment_70101", "id": "reaction_10714862", "reactome": "R-DDI-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674703" ], "products": [ "species_10674705" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "P54632", "DDB_G0269138" ] }, "reaction_10671942": { "compartment": "compartment_70101", "id": "reaction_10671942", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29366", "species_29450" ], "modifiers": [ [ "species_10671939", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10670932": { "compartment": "compartment_70101", "id": "reaction_10670932", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_30537" ], "products": [ "species_70106", "species_29364", "species_31467" ], "modifiers": [ [ "species_10670929", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10712135": { "compartment": "compartment_70101", "id": "reaction_10712135", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712067", "species_10712131" ], "products": [ "species_10712133" ], "modifiers": [], "additional_components": [ "DDB_G0285069", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029", "Q1ZXI2", "DDB_G0279005", "Q54HH3", "DDB_G0289461", "Q54PG2", "DDB_G0284577", "Q54NU5", "DDB_G0285069", "Q54NG7", "DDB_G0285269", "Q554L0", "DDB_G0275005", "Q54U17", "DDB_G0281363", "Q54PZ4", "DDB_G0285269", "Q55D59", "DDB_G0269778", "Q55AA8", "DDB_G0272056", "Q75JL4", "DDB_G0276029" ] }, "reaction_10714804": { "compartment": "compartment_17927", "id": "reaction_10714804", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714798", "species_10714793" ], "products": [ "species_10714802" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10714845": { "compartment": "compartment_7660", "id": "reaction_10714845", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10714828" ], "modifiers": [ [ "species_10714842", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q55G55", "DDB_G0267810", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10711989": { "compartment": "compartment_70101", "id": "reaction_10711989", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711977", "species_113592" ], "products": [ "species_29370", "species_10711987" ], "modifiers": [ [ "species_10675800", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10712001": { "compartment": "compartment_7660", "id": "reaction_10712001", "reactome": "R-DDI-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711997", "species_10676302" ], "products": [ "species_10711999" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10702731": { "compartment": "compartment_70101", "id": "reaction_10702731", "reactome": "R-DDI-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680124", "species_10674719" ], "products": [ "species_10702729" ], "modifiers": [], "additional_components": [ "DDB_G0280527", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54VB2", "DDB_G0280527" ] }, "reaction_10712029": { "compartment": "compartment_7660", "id": "reaction_10712029", "reactome": "R-DDI-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10711993", "species_10712009" ], "products": [ "species_10712011" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q556Z2", "DDB_G0273207", "Q54I13", "DDB_G0289079", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q55F13", "DDB_G0268678", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54G78", "DDB_G0290331" ] }, "reaction_10714303": { "compartment": "compartment_70101", "id": "reaction_10714303", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714299" ], "products": [ "species_10714301" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10699328": { "compartment": "compartment_70101", "id": "reaction_10699328", "reactome": "R-DDI-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10673826" ], "products": [ "species_10673820", "species_29356" ], "modifiers": [ [ "species_10699325", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "Q54N76", "DDB_G0285741", "Q555L5", "DDB_G0274859" ] }, "reaction_10714091": { "compartment": "compartment_7660", "id": "reaction_10714091", "reactome": "R-DDI-6799097", "name": "ATM phosphorylates ZNF420", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10688366" ], "products": [ "species_113582", "species_10714089" ], "modifiers": [ [ "species_10682355", "catalyst" ] ], "additional_components": [ "DDB_G0281085", "DDB_G0281085", "DDB_G0275845" ] }, "reaction_10702706": { "compartment": "compartment_70101", "id": "reaction_10702706", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_10699317" ], "products": [ "species_29356", "species_10702703" ], "modifiers": [ [ "species_10699317", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10680127": { "compartment": "compartment_70101", "id": "reaction_10680127", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10680124" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10702723": { "compartment": "compartment_70101", "id": "reaction_10702723", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702719", "species_10702703" ], "products": [ "species_10702721" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10723422": { "compartment": "compartment_5460", "id": "reaction_10723422", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013199", "species_9012592" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10723420": { "compartment": "compartment_5460", "id": "reaction_10723420", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692485": { "compartment": "compartment_70101", "id": "reaction_10692485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29356" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10724254": { "compartment": "compartment_5460", "id": "reaction_10724254", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724250" ], "products": [ "species_10723093", "species_1655881", "species_10699273" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10716446": { "compartment": "compartment_70101", "id": "reaction_10716446", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_70106", "species_1655445" ], "modifiers": [ [ "species_10716443", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10724248": { "compartment": "compartment_5460", "id": "reaction_10724248", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10723093", "species_9012592" ], "products": [ "species_113557", "species_10724246" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10724252": { "compartment": "compartment_5460", "id": "reaction_10724252", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699270", "species_10724246" ], "products": [ "species_10724250" ], "modifiers": [], "additional_components": [ "DDB_G0284939", "DDB_G0291816", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10692483": { "compartment": "compartment_70101", "id": "reaction_10692483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614532", "species_1614582" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692466": { "compartment": "compartment_70616", "id": "reaction_10692466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614584", "species_198498" ], "products": [ "species_174375", "species_113544" ], "modifiers": [ [ "species_10682771", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10723096": { "compartment": "compartment_5460", "id": "reaction_10723096", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692464": { "compartment": "compartment_5460", "id": "reaction_10692464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614538", "species_113533", "species_113521" ], "products": [ "species_1614584", "species_1614617" ], "modifiers": [ [ "species_10692461", "catalyst" ] ], "additional_components": [ "species_947539", "Q54XJ8", "DDB_G0278893" ] }, "reaction_10692498": { "compartment": "compartment_70101", "id": "reaction_10692498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10692495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10723424": { "compartment": "compartment_5460", "id": "reaction_10723424", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_113557", "species_9013191" ], "modifiers": [ [ "species_10723093", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10692477": { "compartment": "compartment_70101", "id": "reaction_10692477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10692474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10692488": { "compartment": "compartment_70101", "id": "reaction_10692488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_29356" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10723006": { "compartment": "compartment_5460", "id": "reaction_10723006", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_3301973", "species_904849" ], "modifiers": [ [ "species_10723003", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_158543", "Q54YN2", "DDB_G0278155" ] }, "reaction_10677142": { "compartment": "compartment_12045", "id": "reaction_10677142", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_162681", "species_29420" ], "modifiers": [ [ "species_10677139", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q54LP3", "DDB_G0286519", "Q76NT6", "DDB_G0277435" ] }, "reaction_10681323": { "compartment": "compartment_70101", "id": "reaction_10681323", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681315" ], "products": [ "species_10681143", "species_29420" ], "modifiers": [ [ "species_10681320", "catalyst" ] ], "additional_components": [ "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "Q559R0", "DDB_G0272296", "DDB_G0286167" ] }, "reaction_10710261": { "compartment": "compartment_12045", "id": "reaction_10710261", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681143", "species_10681221", "species_10681331" ], "products": [ "species_10681223" ], "modifiers": [], "additional_components": [ "species_29438", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710091": { "compartment": "compartment_12045", "id": "reaction_10710091", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681096", "species_10681325" ], "products": [ "species_10710089" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0269942", "DDB_G0281255", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255" ] }, "reaction_10715624": { "compartment": "compartment_432051", "id": "reaction_10715624", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715620", "species_10715492" ], "products": [ "species_10715622" ], "modifiers": [], "additional_components": [ "Q54I79", "DDB_G0288937", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "Q54VS0", "DDB_G0280175", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "P13022", "DDB_G0272104", "species_29438", "Q54XU5", "DDB_G0278579", "Q54N50", "DDB_G0285503", "P54703", "DDB_G0280849", "Q54TA6", "DDB_G0281889", "Q54VD6", "DDB_G0280435", "species_29420", "Q86A88", "DDB_G0274815", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "Q54ZI7", "DDB_G0277561", "P34036", "DDB_G0276355", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YD8", "DDB_G0278285", "Q54I79", "DDB_G0288937", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54VS0", "DDB_G0280175", "Q54NU2", "DDB_G0284985", "P54703", "DDB_G0280849", "Q54FM4", "DDB_G0290757", "Q54JY2", "DDB_G0287739", "P34141", "DDB_G0291233", "P34036", "DDB_G0276355", "Q55FU2", "DDB_G0267950", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54N50", "DDB_G0285503", "Q54TA6", "DDB_G0281889", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54Q34", "DDB_G0349530", "Q54V78", "DDB_G0349530", "P13022", "DDB_G0272104", "Q54XU5", "DDB_G0278579", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q54VD6", "DDB_G0280435", "species_29420", "Q1ZXJ2", "DDB_G0294557", "Q54ZI7", "DDB_G0277561", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54CI8", "DDB_G0292904", "P32255", "DDB_G0287689", "P13021", "DDB_G0267374", "P32256", "DDB_G0269196", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q86A88", "DDB_G0274815", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q23924", "DDB_G0284735" ] }, "reaction_10715495": { "compartment": "compartment_6791047", "id": "reaction_10715495", "reactome": "R-DDI-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715384" ], "products": [ "species_10715128", "species_10715276", "species_10715492", "species_10715194" ], "modifiers": [ [ "species_10715384", "catalyst" ] ], "additional_components": [ "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54TP9", "DDB_G0292148", "Q54DK9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54HD4", "DDB_G0289523", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54TP9", "DDB_G0292148", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q75JP5", "DDB_G0294557", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54DK9", "DDB_G0292148", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Q34", "DDB_G0349530", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54V78", "DDB_G0349530", "Q54V41", "DDB_G0280633", "Q550R2", "DDB_G0276893", "Q553R1", "DDB_G0275331", "Q769F7", "DDB_G0278969", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "Q55FR9", "DDB_G0267982", "P05095", "DDB_G0268632", "Q769F6", "DDB_G0277923", "Q54JJ3", "DDB_G0288015", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "species_29438", "Q54HD4", "DDB_G0289523", "Q54BN0", "DDB_G0293540", "Q54HL0", "DDB_G0289371", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q86JE5", "DDB_G0272124", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10716722": { "compartment": "compartment_6791047", "id": "reaction_10716722", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716717" ], "products": [ "species_10710015", "species_10716715" ], "modifiers": [ [ "species_10716717", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710154": { "compartment": "compartment_6791047", "id": "reaction_10710154", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710119", "species_10710150", "species_10710110" ], "products": [ "species_10710152" ], "modifiers": [], "additional_components": [ "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710161": { "compartment": "compartment_13959", "id": "reaction_10710161", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710064", "species_10710015", "species_10681311" ], "products": [ "species_10710066" ], "modifiers": [], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q55CT5", "DDB_G0270992", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10710218": { "compartment": "compartment_6791047", "id": "reaction_10710218", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10710176" ], "products": [ "species_29370", "species_10681091", "species_10710180", "species_10710182", "species_10710064", "species_10710103", "species_10710210" ], "modifiers": [ [ "species_10710215", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q553R1", "DDB_G0275331", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q54BK5", "DDB_G0293712", "Q553R1", "DDB_G0275331", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q557G3", "DDB_G0273467", "Q54RV6", "DDB_G0282887", "Q86K94", "DDB_G0277135", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "DDB_G0273059" ] }, "reaction_10715198": { "compartment": "compartment_6791047", "id": "reaction_10715198", "reactome": "R-DDI-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715134", "species_10715194" ], "products": [ "species_10715196" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q54JJ3", "DDB_G0288015", "Q54HK2", "DDB_G0289435", "Q1ZXA5", "DDB_G0292332", "Q54V41", "DDB_G0280633", "species_29420", "Q54SH9", "DDB_G0282457", "Q554Y8", "DDB_G0274445", "Q54V47", "DDB_G0280621", "Q54I24", "DDB_G0289069", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54VB0", "DDB_G0280479", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715136": { "compartment": "compartment_6791047", "id": "reaction_10715136", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715128", "species_10715132", "species_10710210" ], "products": [ "species_10715134" ], "modifiers": [], "additional_components": [ "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86KG9", "DDB_G0290771", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233" ] }, "reaction_10716719": { "compartment": "compartment_6791047", "id": "reaction_10716719", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716715", "species_10710210" ], "products": [ "species_10716717" ], "modifiers": [], "additional_components": [ "DDB_G0283055", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54RT5", "DDB_G0283055", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233" ] }, "reaction_10710157": { "compartment": "compartment_6791047", "id": "reaction_10710157", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710152", "species_113592" ], "products": [ "species_10710126", "species_10710131", "species_10710140", "species_10710124", "species_10710119", "species_10710148", "species_29372", "species_10710110" ], "modifiers": [ [ "species_10710152", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0288719", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q55CR0", "DDB_G0269942", "Q54JY7", "DDB_G0287733", "Q54ZH1", "DDB_G0277565", "Q75JI3", "DDB_G0276153", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54IJ1", "DDB_G0288719", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710264": { "compartment": "compartment_70101", "id": "reaction_10710264", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681223" ], "products": [ "species_10681221", "species_10681331", "species_29372", "species_10681315" ], "modifiers": [ [ "species_10681223", "catalyst" ] ], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "species_29420", "Q559R0", "DDB_G0272296", "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452" ] }, "reaction_10715205": { "compartment": "compartment_6791047", "id": "reaction_10715205", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10715196" ], "products": [ "species_10715202", "species_29370" ], "modifiers": [ [ "species_10715196", "catalyst" ] ], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "species_29420", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792" ] }, "reaction_10715260": { "compartment": "compartment_6791047", "id": "reaction_10715260", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715202", "species_10715256" ], "products": [ "species_10715258" ], "modifiers": [], "additional_components": [ "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "species_29438", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q55FR9", "DDB_G0267982", "Q54YD8", "DDB_G0278285", "Q54HL0", "DDB_G0289371", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q55FU2", "DDB_G0267950", "Q23924", "DDB_G0284735", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q54YV7", "DDB_G0278057", "O00909", "DDB_G0289173", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54HK2", "DDB_G0289435", "Q54NU2", "DDB_G0284985", "Q54V41", "DDB_G0280633", "Q553R1", "DDB_G0275331", "Q54FL9", "DDB_G0290771", "Q554Y8", "DDB_G0274445", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q54VB0", "DDB_G0280479", "Q55FR9", "DDB_G0267982", "Q86KG9", "DDB_G0290771", "Q54JJ3", "DDB_G0288015", "Q1ZXA5", "DDB_G0292332", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54EW9", "DDB_G0291293", "species_29438", "Q54HD4", "DDB_G0289523", "Q558I0", "DDB_G0272905", "Q54SH9", "DDB_G0282457", "Q54HL0", "DDB_G0289371", "Q54V47", "DDB_G0280621", "Q54X30", "DDB_G0290771", "Q54DF4", "DDB_G0292300", "Q54I24", "DDB_G0289069", "Q552K3", "DDB_G0275969", "Q54Y34", "DDB_G0292332", "Q55AR1", "DDB_G0271792", "Q23924", "DDB_G0284735" ] }, "reaction_10715820": { "compartment": "compartment_20699", "id": "reaction_10715820", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715816", "species_10710119", "species_10710110" ], "products": [ "species_10715818" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10710087": { "compartment": "compartment_12045", "id": "reaction_10710087", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681161", "species_10681157", "species_10681155" ], "products": [ "species_10681163" ], "modifiers": [], "additional_components": [ "DDB_G0281985", "DDB_G0277797", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54T59", "DDB_G0281985", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q55FD0", "DDB_G0268452" ] }, "reaction_10681337": { "compartment": "compartment_12045", "id": "reaction_10681337", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681229", "species_10681091", "species_10681104" ], "products": [ "species_10681231" ], "modifiers": [], "additional_components": [ "Q54T59", "DDB_G0281985", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "species_29438", "Q55BR0", "DDB_G0269198", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296", "Q55FD0", "DDB_G0268452", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q54DS8", "DDB_G0292052", "Q55CR0", "DDB_G0269942", "Q54BK5", "DDB_G0293712", "Q54T59", "DDB_G0281985", "Q55CT5", "DDB_G0270992", "Q556P7", "DDB_G0281139", "Q54Z72", "DDB_G0277797", "species_29438", "Q55BR0", "DDB_G0269198", "Q54BK5", "DDB_G0293712", "Q54DS8", "DDB_G0292052", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q8T2J5", "DDB_G0271968", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54VR1", "DDB_G0280187", "Q54U61", "DDB_G0281255", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q559R0", "DDB_G0272296" ] }, "reaction_10710159": { "compartment": "compartment_12045", "id": "reaction_10710159", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10681217", "species_10681211" ], "products": [ "species_10681219" ], "modifiers": [], "additional_components": [ "DDB_G0280187", "Q8T2J5", "DDB_G0271968", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q556P7", "DDB_G0281139", "Q54UD7", "DDB_G0281139", "Q86I39", "DDB_G0281139" ] }, "reaction_10710073": { "compartment": "compartment_13959", "id": "reaction_10710073", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10710066" ], "products": [ "species_10710070", "species_29420" ], "modifiers": [ [ "species_10710066", "catalyst" ] ], "additional_components": [ "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "P34140", "DDB_G0277867", "Q555X3", "DDB_G0274803", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54DF4", "DDB_G0292300", "Q54TK7", "DDB_G0281693", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139", "Q54YG5", "DDB_G0278643", "Q55CT5", "DDB_G0270992", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54NU2", "DDB_G0284985", "Q54RV6", "DDB_G0282887", "Q54DS8", "DDB_G0292052", "species_29420", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0280187", "Q555X3", "DDB_G0274803", "P34140", "DDB_G0277867", "Q557G3", "DDB_G0273467", "Q54U61", "DDB_G0281255", "P34141", "DDB_G0291233", "Q86I39", "DDB_G0281139", "Q54T59", "DDB_G0281985", "Q556P7", "DDB_G0281139", "P34139", "DDB_G0283757", "Q54Z72", "DDB_G0277797", "Q54EW9", "DDB_G0291293", "Q54BK5", "DDB_G0293712", "Q86K94", "DDB_G0277135", "Q55FD0", "DDB_G0268452", "Q55CR0", "DDB_G0269942", "Q558I0", "DDB_G0272905", "Q54ZH1", "DDB_G0277565", "Q54EA5", "DDB_G0291694", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54UD7", "DDB_G0281139" ] }, "reaction_10715814": { "compartment": "compartment_20699", "id": "reaction_10715814", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715791", "species_10715810" ], "products": [ "species_10715812" ], "modifiers": [], "additional_components": [ "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q55FD0", "DDB_G0268452", "Q54YD8", "DDB_G0278285", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54V78", "DDB_G0349530", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q550R2", "DDB_G0276893", "Q769F7", "DDB_G0278969", "Q55BB8", "DDB_G0271388", "Q54C87", "DDB_G0293106", "Q1ZXJ2", "DDB_G0294557", "P34140", "DDB_G0277867", "Q769F9", "DDB_G0288053", "P34141", "DDB_G0291233", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q769F6", "DDB_G0277923", "P05095", "DDB_G0268632", "Q75JP5", "DDB_G0294557", "Q54QH2", "DDB_G0283831", "P34139", "DDB_G0283757", "Q55EZ6", "DDB_G0268702", "species_29438", "Q54EW9", "DDB_G0291293", "Q54CA7", "DDB_G0293086", "Q54BK5", "DDB_G0293712", "Q54YV5", "DDB_G0278061", "Q54HD4", "DDB_G0289523", "Q54LC8", "DDB_G0286705", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54SJ2", "DDB_G0282433", "Q558I0", "DDB_G0272905", "Q54BN0", "DDB_G0293540", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54HL0", "DDB_G0289371", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q54CT0", "DDB_G0292784", "Q86JE5", "DDB_G0272124", "Q54Q34", "DDB_G0349530", "Q23924", "DDB_G0284735", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10715823": { "compartment": "compartment_20699", "id": "reaction_10715823", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715818", "species_113592" ], "products": [ "species_10715804", "species_10715796", "species_29372", "species_10715800", "species_10715779", "species_10715679", "species_10715798" ], "modifiers": [ [ "species_10715818", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452", "DDB_G0268452", "DDB_G0283831", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q55FD0", "DDB_G0268452" ] }, "reaction_10725871": { "compartment": "compartment_70101", "id": "reaction_10725871", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10677557" ], "products": [ "species_10725869" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678991" ] }, "reaction_10689890": { "compartment": "compartment_876", "id": "reaction_10689890", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10689887", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10724463": { "compartment": "compartment_876", "id": "reaction_10724463", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724456", "species_179838", "species_113592" ], "products": [ "species_29370", "species_10724461" ], "modifiers": [], "additional_components": [ "DDB_G0281265", "Q54U56", "DDB_G0281265", "species_179838" ] }, "reaction_10676519": { "compartment": "compartment_17906", "id": "reaction_10676519", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676517" ], "products": [ "species_10676515" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10675766": { "compartment": "compartment_7660", "id": "reaction_10675766", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672167", "species_10674774" ], "products": [ "species_10674776" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675764": { "compartment": "compartment_7660", "id": "reaction_10675764", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674115", "species_10674110", "species_10674772" ], "products": [ "species_10674774" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54FD6", "DDB_G0290929", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675762": { "compartment": "compartment_7660", "id": "reaction_10675762", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10674181" ], "products": [ "species_10674772" ], "modifiers": [], "additional_components": [ "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675768": { "compartment": "compartment_7660", "id": "reaction_10675768", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10674778" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674780": { "compartment": "compartment_7660", "id": "reaction_10674780", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674193", "species_10674776" ], "products": [ "species_10674778" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10675912": { "compartment": "compartment_7660", "id": "reaction_10675912", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675909" ], "products": [ "species_10675902", "species_110216" ], "modifiers": [ [ "species_10675909", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675921": { "compartment": "compartment_7660", "id": "reaction_10675921", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675916" ], "products": [ "species_110223", "species_10675918" ], "modifiers": [ [ "species_10675916", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675942": { "compartment": "compartment_7660", "id": "reaction_10675942", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675939" ], "products": [ "species_10675918", "species_5637659" ], "modifiers": [ [ "species_10675939", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675905": { "compartment": "compartment_7660", "id": "reaction_10675905", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675898" ], "products": [ "species_10675902", "species_29554" ], "modifiers": [ [ "species_10675898", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10675961": { "compartment": "compartment_7660", "id": "reaction_10675961", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675958" ], "products": [ "species_10675953", "species_5636006" ], "modifiers": [ [ "species_10675958", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675935": { "compartment": "compartment_7660", "id": "reaction_10675935", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675932" ], "products": [ "species_30140", "species_10675918" ], "modifiers": [ [ "species_10675932", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10675928": { "compartment": "compartment_7660", "id": "reaction_10675928", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675925" ], "products": [ "species_10675918", "species_110225" ], "modifiers": [ [ "species_10675925", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10699054": { "compartment": "compartment_984", "id": "reaction_10699054", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299686", "species_351626" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10699051", "catalyst" ] ], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699338": { "compartment": "compartment_70101", "id": "reaction_10699338", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29408", "species_29450" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10699335", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54SE2", "DDB_G0282517", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10699064": { "compartment": "compartment_70101", "id": "reaction_10699064", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29408", "species_29368" ], "modifiers": [ [ "species_10699061", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10675004": { "compartment": "compartment_17951", "id": "reaction_10675004", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_141343", "species_113535" ], "modifiers": [ [ "species_10675001", "catalyst" ] ], "additional_components": [ "O77229", "DDB_G0274595", "species_71185", "species_5623644" ] }, "reaction_10699781": { "compartment": "compartment_70101", "id": "reaction_10699781", "reactome": "R-DDI-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222481", "species_10673826" ], "products": [ "species_10673820", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10699323", "catalyst" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "DDB_G0285741" ] }, "reaction_10699292": { "compartment": "compartment_5460", "id": "reaction_10699292", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614617", "species_10699270" ], "products": [ "species_113521", "species_10699273" ], "modifiers": [ [ "species_10699289", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54N76", "DDB_G0285741", "Q54W09", "DDB_G0279973" ] }, "reaction_10699784": { "compartment": "compartment_5460", "id": "reaction_10699784", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3697881", "species_10699270" ], "products": [ "species_113521", "species_3697842", "species_10699273" ], "modifiers": [ [ "species_10699287", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10715116": { "compartment": "compartment_12045", "id": "reaction_10715116", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_29368" ], "products": [ "species_70106", "species_29366", "species_1222424" ], "modifiers": [ [ "species_10715113", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10699307": { "compartment": "compartment_70616", "id": "reaction_10699307", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677284", "species_3341308" ], "products": [ "species_10677282", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10699937": { "compartment": "compartment_17927", "id": "reaction_10699937", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10699934", "catalyst" ] ], "additional_components": [ "species_29426", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10698995": { "compartment": "compartment_5460", "id": "reaction_10698995", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3299683", "species_113529" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10698992", "catalyst" ] ], "additional_components": [ "species_29418", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10700993": { "compartment": "compartment_17963", "id": "reaction_10700993", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700991" ], "products": [ "species_10699051" ], "modifiers": [], "additional_components": [ "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420", "Q54TU5", "DDB_G0281493", "species_29426", "Q54G70", "DDB_G0290343", "Q54F73", "DDB_G0291031", "Q54TW8", "DDB_G0281461", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_936901", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10699301": { "compartment": "compartment_5460", "id": "reaction_10699301", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113600", "species_1655882", "species_113529" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10699298", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10697280": { "compartment": "compartment_70101", "id": "reaction_10697280", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10697277", "catalyst" ] ], "additional_components": [ "Q54S89", "DDB_G0282603", "species_29926" ] }, "reaction_10670550": { "compartment": "compartment_7660", "id": "reaction_10670550", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670546", "species_10670361" ], "products": [ "species_10670548" ], "modifiers": [], "additional_components": [ "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702" ] }, "reaction_10670588": { "compartment": "compartment_7660", "id": "reaction_10670588", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670563", "species_10670584" ], "products": [ "species_10670586" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54TN8", "DDB_G0281641", "Q54N97", "DDB_G0285381", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607" ] }, "reaction_10670565": { "compartment": "compartment_7660", "id": "reaction_10670565", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670559" ], "products": [ "species_10670546", "species_10670563" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54K47", "DDB_G0287607" ] }, "reaction_10670561": { "compartment": "compartment_7660", "id": "reaction_10670561", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670557", "species_29358", "species_10670548" ], "products": [ "species_113582", "species_10670559" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q55BM5", "DDB_G0270442", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702" ] }, "reaction_10716868": { "compartment": "compartment_20699", "id": "reaction_10716868", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716859" ], "products": [ "species_10716865" ], "modifiers": [ [ "species_10716859", "catalyst" ] ], "additional_components": [ "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771", "species_29420", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10717007": { "compartment": "compartment_20699", "id": "reaction_10717007", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717003", "species_10715666" ], "products": [ "species_10717005" ], "modifiers": [], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q55FK2", "DDB_G0268068", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q1ZXG2", "DDB_G0294577", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716805": { "compartment": "compartment_20699", "id": "reaction_10716805", "reactome": "R-DDI-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716801" ], "products": [ "species_10716803" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "O00909", "DDB_G0289173", "Q55BL9", "DDB_G0346831", "Q54Y02", "DDB_G0278495", "CHEBI:15996" ] }, "reaction_10716884": { "compartment": "compartment_20699", "id": "reaction_10716884", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716880", "species_10716874" ], "products": [ "species_10716882" ], "modifiers": [], "additional_components": [ "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716861": { "compartment": "compartment_20699", "id": "reaction_10716861", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693010", "species_10716831" ], "products": [ "species_10716859" ], "modifiers": [], "additional_components": [ "O00909", "DDB_G0289173", "CHEBI:15996", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54X30", "DDB_G0290771", "CHEBI:15996", "Q54FL9", "DDB_G0290771" ] }, "reaction_10716313": { "compartment": "compartment_20699", "id": "reaction_10716313", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716309", "species_10715666" ], "products": [ "species_10716311" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q551H5", "DDB_G0276575", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54HE0", "DDB_G0289535", "Q54UC2", "DDB_G0281163", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54QH2", "DDB_G0283831", "Q553C3", "DDB_G0275765", "Q55GN5", "DDB_G0267590", "Q54GE3", "DDB_G0290213", "Q55BB8", "DDB_G0271388", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q55FD0", "DDB_G0268452", "Q54R67", "DDB_G0283363", "Q54SJ2", "DDB_G0282433", "Q54PQ5", "DDB_G0284385", "Q54ZH1", "DDB_G0277565", "Q54TT4", "DDB_G0281511", "Q54CT0", "DDB_G0292784", "Q551H5", "DDB_G0276575", "Q54ZB3", "DDB_G0277691" ] }, "reaction_10716784": { "compartment": "compartment_20699", "id": "reaction_10716784", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716780", "species_10710119", "species_10710110" ], "products": [ "species_10716782" ], "modifiers": [], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10716787": { "compartment": "compartment_20699", "id": "reaction_10716787", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716782" ], "products": [ "species_29370", "species_10715796", "species_10710119", "species_10715800", "species_10715679", "species_10710110", "species_10715798" ], "modifiers": [ [ "species_10716782", "catalyst" ] ], "additional_components": [ "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0277565", "DDB_G0293712", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "Q54SJ2", "DDB_G0282433", "Q75JI3", "DDB_G0276153", "Q54ZH1", "DDB_G0277565", "Q54QH2", "DDB_G0283831", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712" ] }, "reaction_10709489": { "compartment": "compartment_70101", "id": "reaction_10709489", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709484", "species_29356" ], "products": [ "species_1131871", "species_10709486" ], "modifiers": [ [ "species_10709484", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54T48", "DDB_G0282007", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10703500": { "compartment": "compartment_70101", "id": "reaction_10703500", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703441", "species_10670356" ], "products": [ "species_10703443" ], "modifiers": [], "additional_components": [ "DDB_G0272624", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703447": { "compartment": "compartment_70101", "id": "reaction_10703447", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703443", "species_10703436" ], "products": [ "species_10703445" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "DDB_G0285527", "Q54N38", "DDB_G0285527", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10717861": { "compartment": "compartment_70101", "id": "reaction_10717861", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717713" ], "products": [ "species_76577", "species_10717709" ], "modifiers": [ [ "species_10717713", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10702140": { "compartment": "compartment_70101", "id": "reaction_10702140", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702129" ], "products": [ "species_10702132", "species_71285" ], "modifiers": [ [ "species_10702137", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10700403": { "compartment": "compartment_7660", "id": "reaction_10700403", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10696675" ], "products": [ "species_10698305", "species_10700401" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10673665": { "compartment": "compartment_70101", "id": "reaction_10673665", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673661", "species_10673298" ], "products": [ "species_10673300" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10687107": { "compartment": "compartment_17957", "id": "reaction_10687107", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686806", "species_10687103" ], "products": [ "species_10687105" ], "modifiers": [], "additional_components": [ "Q54BW3", "DDB_G0293378", "Q54EN4", "DDB_G0291434", "Q23858", "DDB_G0283539", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "Q54BW3", "DDB_G0293378", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q54EN4", "DDB_G0291434" ] }, "reaction_10700206": { "compartment": "compartment_7660", "id": "reaction_10700206", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684083", "species_10698318" ], "products": [ "species_10698305", "species_10700198" ], "modifiers": [ [ "species_10700203", "catalyst" ] ], "additional_components": [ "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54UJ3", "DDB_G0281045", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "DDB_G0281183" ] }, "reaction_10700515": { "compartment": "compartment_7660", "id": "reaction_10700515", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700491" ], "products": [ "species_10700504", "species_10698305" ], "modifiers": [ [ "species_10700512", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0278203", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10705691": { "compartment": "compartment_3828046", "id": "reaction_10705691", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705524", "species_5685882" ], "products": [ "species_10705620", "species_10705588", "species_10705556" ], "modifiers": [ [ "species_10705688", "catalyst" ] ], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "P54639", "DDB_G0278721", "Q94503", "DDB_G0279185", "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10683855": { "compartment": "compartment_70101", "id": "reaction_10683855", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683798", "species_10683851" ], "products": [ "species_10683853" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q6B516", "DDB_G0284545", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741" ] }, "reaction_10673340": { "compartment": "compartment_70101", "id": "reaction_10673340", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673329" ], "products": [ "species_29370", "species_10673329", "species_29372" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10684883": { "compartment": "compartment_17938", "id": "reaction_10684883", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_70106", "species_428633" ], "modifiers": [ [ "species_10684880", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10685907": { "compartment": "compartment_70101", "id": "reaction_10685907", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_76183" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10685904", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10709063": { "compartment": "compartment_7660", "id": "reaction_10709063", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10707630" ], "products": [ "species_10709060", "species_10707644" ], "modifiers": [ [ "species_10707630", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10685919": { "compartment": "compartment_5460", "id": "reaction_10685919", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_159450" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10685916", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10676992": { "compartment": "compartment_70101", "id": "reaction_10676992", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676983", "species_10676987" ], "products": [ "species_10676969", "species_10676989" ], "modifiers": [ [ "species_10676983", "catalyst" ] ], "additional_components": [ "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10724695": { "compartment": "compartment_12045", "id": "reaction_10724695", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724693" ], "products": [ "species_10705524" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10682226": { "compartment": "compartment_876", "id": "reaction_10682226", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682212", "species_10682207", "species_10682222", "species_10682192", "species_10682187", "species_10682217", "species_10682197", "species_10682202" ], "products": [ "species_10682224" ], "modifiers": [], "additional_components": [ "DDB_G0285067", "DDB_G0279991", "DDB_G0272991", "DDB_G0280081", "DDB_G0284833", "DDB_G0293520", "DDB_G0287881", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54VX5", "DDB_G0280081", "Q558Z9", "DDB_G0272991", "Q54VZ8", "DDB_G0279991", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54P76", "DDB_G0284833", "Q54B27", "DDB_G0293936" ] }, "reaction_10710630": { "compartment": "compartment_7660", "id": "reaction_10710630", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710625" ], "products": [ "species_10709060", "species_10710627" ], "modifiers": [ [ "species_10710625", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10698407": { "compartment": "compartment_7660", "id": "reaction_10698407", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698318" ], "products": [ "species_10698305", "species_10698405" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54C05", "DDB_G0293300", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710874": { "compartment": "compartment_7660", "id": "reaction_10710874", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710869" ], "products": [ "species_10708452", "species_10710871" ], "modifiers": [ [ "species_10710869", "catalyst" ] ], "additional_components": [ "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827", "Q54LI3", "DDB_G0286805", "Q54PU3", "DDB_G0286805", "Q86J16", "DDB_G0274827" ] }, "reaction_10686727": { "compartment": "compartment_70101", "id": "reaction_10686727", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10686724", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10711136": { "compartment": "compartment_70101", "id": "reaction_10711136", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_6787618", "species_29356" ], "modifiers": [ [ "species_10711133", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10722373": { "compartment": "compartment_17947", "id": "reaction_10722373", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722365", "species_10722369" ], "products": [ "species_10722371" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10711128": { "compartment": "compartment_70101", "id": "reaction_10711128", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10687947": { "compartment": "compartment_70101", "id": "reaction_10687947", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687940" ], "products": [ "species_10670153", "species_10687942" ], "modifiers": [ [ "species_10687944", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10673351": { "compartment": "compartment_70101", "id": "reaction_10673351", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673316", "species_10673311", "species_10673321" ], "products": [ "species_10673323" ], "modifiers": [], "additional_components": [ "DDB_G0268574", "P90529", "DDB_G0269146", "DDB_G0275395", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574" ] }, "reaction_10702162": { "compartment": "compartment_70101", "id": "reaction_10702162", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10702142" ], "products": [ "species_353106", "species_10702129" ], "modifiers": [ [ "species_10702159", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "B0G132", "DDB_G0295687", "Q54PW5", "DDB_G0284257", "Q7KWL8", "DDB_G0277061" ] }, "reaction_10673659": { "compartment": "compartment_70101", "id": "reaction_10673659", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673640" ], "products": [ "species_10673277", "species_10673638", "species_10673208" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0278205", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10709775": { "compartment": "compartment_984", "id": "reaction_10709775", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_109276" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10709772", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10722383": { "compartment": "compartment_17947", "id": "reaction_10722383", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722371" ], "products": [ "species_10690046", "species_10722380" ], "modifiers": [ [ "species_10722371", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10673655": { "compartment": "compartment_70101", "id": "reaction_10673655", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673649" ], "products": [ "species_10673651", "species_29372", "species_10673653" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", 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"Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "species_29420", "Q54XP6", "DDB_G0278815", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10677197": { "compartment": "compartment_12045", "id": "reaction_10677197", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10677194", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10681359": { "compartment": "compartment_70101", "id": "reaction_10681359", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_204628", "species_10681343" ], "products": [ "species_29360", "species_204635", "species_10681347" ], "modifiers": [ [ "species_10681356", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10688493": { "compartment": "compartment_17963", "id": "reaction_10688493", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_914003" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10688490", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10717967": { "compartment": "compartment_70101", "id": "reaction_10717967", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717965" ], "products": [ "species_10669997", "species_10669975", "species_10670019" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10702126": { "compartment": "compartment_70101", "id": "reaction_10702126", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_31633", "species_10702118" ], "products": [ "species_10676998", "species_111294", "species_76577" ], "modifiers": [ [ "species_10702123", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10698428": { "compartment": "compartment_7660", "id": "reaction_10698428", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698412", "species_10698318" ], "products": [ "species_10698305", "species_10698425" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54LN0", "DDB_G0286539", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10716428": { "compartment": "compartment_70101", "id": "reaction_10716428", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682961", "species_10683851" ], "products": [ "species_10716426" ], "modifiers": [], "additional_components": [ "DDB_G0277143", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10721435": { "compartment": "compartment_70101", "id": "reaction_10721435", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721415", "species_10721431", "species_10721429" ], "products": [ "species_10721433" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10677189": { "compartment": "compartment_12045", "id": "reaction_10677189", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10677186", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10721463": { "compartment": "compartment_70101", "id": "reaction_10721463", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721452", "species_10721450" ], "products": [ "species_10721443", "species_10721460", "species_10680834" ], "modifiers": [ [ "species_10721452", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0277267", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10700718": { "compartment": "compartment_7660", "id": "reaction_10700718", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670555", "species_10698318" ], "products": [ "species_10698305", "species_10700716" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10721734": { "compartment": "compartment_7660", "id": "reaction_10721734", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721712", "species_10721731" ], "products": [ "species_10721719", "species_10705259", "species_10721729", "species_10721706" ], "modifiers": [ [ "species_10721731", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082", "Q54K47", "DDB_G0287607", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "DDB_G0272082", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10700659": { "compartment": "compartment_7660", "id": "reaction_10700659", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700639" ], "products": [ "species_10698305", "species_10700657" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0272690", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685756": { "compartment": "compartment_70101", "id": "reaction_10685756", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532204", "species_29494" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10685753", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10685711": { "compartment": "compartment_17957", "id": "reaction_10685711", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449312", "species_449229" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10685708", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10719651": { "compartment": "compartment_70101", "id": "reaction_10719651", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719273", "species_10719647" ], "products": [ "species_10719649" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10711110": { "compartment": "compartment_70101", "id": "reaction_10711110", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_742368", "species_111294" ], "modifiers": [ [ "species_10711107", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10700169": { "compartment": "compartment_7660", "id": "reaction_10700169", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698318" ], "products": [ "species_10698305", "species_10700167" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10707595": { "compartment": "compartment_70101", "id": "reaction_10707595", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707592", "species_10689017" ], "products": [ "species_10706130" ], "modifiers": [ [ "species_10689017", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10711231": { "compartment": "compartment_12045", "id": "reaction_10711231", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_6788758", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ] ], "additional_components": [ "species_29426", "Q558K8", "DDB_G0272799" ] }, "reaction_10717943": { "compartment": "compartment_70101", "id": "reaction_10717943", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717940" ], "products": [ "species_10670107", "species_10669997", "species_10670151", "species_10670085", "species_10670063", "species_10669975", "species_10670041", "species_10670019", "species_10670129" ], "modifiers": [ [ "species_10709116", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0291239" ] }, "reaction_10672012": { "compartment": "compartment_70101", "id": "reaction_10672012", "reactome": "R-DDI-71732", "name": "PPA1 hydrolyzes pyrophosphate to orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10672009", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10717761": { "compartment": "compartment_70101", "id": "reaction_10717761", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717711", "species_10717707" ], "products": [ "species_10717759", "species_10717713" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q75JE1", "DDB_G0288345", "O76542", "DDB_G0284009", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q54J27", "DDB_G0288345", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54VW9", "DDB_G0280091", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10685772": { "compartment": "compartment_12045", "id": "reaction_10685772", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_449299" ], "products": [ "species_110096", "species_532214" ], "modifiers": [ [ "species_10685769", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10685897": { "compartment": "compartment_70101", "id": "reaction_10685897", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29512" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10685894", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10687188": { "compartment": "compartment_17963", "id": "reaction_10687188", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_205687", "species_10687186" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700814": { "compartment": "compartment_7660", "id": "reaction_10700814", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700799", "species_10698318" ], "products": [ "species_10698305", "species_10700812" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54RC3", "DDB_G0283205", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717887": { "compartment": "compartment_70101", "id": "reaction_10717887", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689659", "species_29356" ], "products": [ "species_8853381", "species_8853371" ], "modifiers": [ [ "species_10717884", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628", "species_6799543", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10716434": { "compartment": "compartment_70101", "id": "reaction_10716434", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716432" ], "products": [ "species_10716426", "species_29372" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10677122": { "compartment": "compartment_17957", "id": "reaction_10677122", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_76194", "species_8855666" ], "modifiers": [ [ "species_10677119", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10711139": { "compartment": "compartment_70101", "id": "reaction_10711139", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_6787646" ], "products": [ "species_29366", "species_742368" ], "modifiers": [ [ "species_10711125", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10673349": { "compartment": "compartment_70101", "id": "reaction_10673349", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347" ], "products": [ "species_10673345", "species_10673316" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10685719": { "compartment": "compartment_12045", "id": "reaction_10685719", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449744", "species_29356" ], "products": [ "species_449299", "species_29372" ], "modifiers": [ [ "species_10685716", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10698470": { "compartment": "compartment_7660", "id": "reaction_10698470", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698438" ], "products": [ "species_10698305", "species_10698453" ], "modifiers": [ [ "species_10698467", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0285989", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54MF7", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10711352": { "compartment": "compartment_3828046", "id": "reaction_10711352", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705556" ], "products": [ "species_10705693" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508", "Q54WE0", "DDB_G0292508", "Q54PT7", "DDB_G0292508", "Q55EI1", "DDB_G0268890", "Q54SX7", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q54Q68", "DDB_G0284043", "Q54LG2", "DDB_G0286561", "Q54WE4", "DDB_G0292508", "Q54LG1", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q75K05", "DDB_G0292508" ] }, "reaction_10677228": { "compartment": "compartment_12045", "id": "reaction_10677228", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855665", "species_449229" ], "products": [ "species_162872", "species_8855659" ], "modifiers": [ [ "species_10677225", "catalyst" ] ], "additional_components": [ "Q54IA4", "DDB_G0288899", "Q54QP2", "DDB_G0283717" ] }, "reaction_10717705": { "compartment": "compartment_7660", "id": "reaction_10717705", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717501", "species_29358", "species_10669917" ], "products": [ "species_10717703", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721722": { "compartment": "compartment_7660", "id": "reaction_10721722", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721714", "species_10721712" ], "products": [ "species_10721719", "species_10721697", "species_10705259", "species_10721706" ], "modifiers": [ [ "species_10721714", "catalyst" ] ], "additional_components": [ "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10721724": { "compartment": "compartment_7660", "id": "reaction_10721724", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721697", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721714" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10719266": { "compartment": "compartment_70101", "id": "reaction_10719266", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719256", "species_10719262" ], "products": [ "species_10719264" ], "modifiers": [ [ "species_10719258", "inhibitor" ] ], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10718520": { "compartment": "compartment_7660", "id": "reaction_10718520", "reactome": "R-DDI-8862184", "name": "USP48 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718471" ], "products": [ "species_10718517", "species_10708452" ], "modifiers": [ [ "species_10718471", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q556A3", "DDB_G0274795", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961" ] }, "reaction_10700592": { "compartment": "compartment_7660", "id": "reaction_10700592", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10674568" ], "products": [ "species_10698305", "species_10700590" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0276863", "DDB_G0287693", "DDB_G0276863", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10707609": { "compartment": "compartment_70101", "id": "reaction_10707609", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10707605", "species_10703443" ], "products": [ "species_10707607" ], "modifiers": [], "additional_components": [ "DDB_G0271264", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q55BC4", "DDB_G0271264", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q556N5", "DDB_G0272624", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10719260": { "compartment": "compartment_70101", "id": "reaction_10719260", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719254", "species_10719256" ], "products": [ "species_10719258" ], "modifiers": [], "additional_components": [ "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024" ] }, "reaction_10700140": { "compartment": "compartment_7660", "id": "reaction_10700140", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698387", "species_10698318" ], "products": [ "species_10698305", "species_10700138" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10676985": { "compartment": "compartment_70101", "id": "reaction_10676985", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676976", "species_10676974", "species_10676981" ], "products": [ "species_10676983" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0284035", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10717858": { "compartment": "compartment_70101", "id": "reaction_10717858", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10717709" ], "products": [ "species_10717711", "species_111294" ], "modifiers": [ [ "species_10717709", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10720438": { "compartment": "compartment_70101", "id": "reaction_10720438", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720435" ], "products": [ "species_10680330" ], "modifiers": [ [ "species_10715078", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0267906" ] }, "reaction_10700761": { "compartment": "compartment_7660", "id": "reaction_10700761", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700746" ], "products": [ "species_10698305", "species_10700759" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0270418", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10717853": { "compartment": "compartment_7660", "id": "reaction_10717853", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717765", "species_10717800" ], "products": [ "species_10717851", "species_10717703" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "Q54IK3", "DDB_G0290547", "Q54J27", "DDB_G0288345", "Q55EY8", "DDB_G0268938", "Q54FR5", "DDB_G0290629", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q75JE1", "DDB_G0288345", "Q54F00", "DDB_G0291199", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54XS6", "DDB_G0278775", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "Q54I43", "DDB_G0289021", "O76542", "DDB_G0284009", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54J27", "DDB_G0288345", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721441": { "compartment": "compartment_70101", "id": "reaction_10721441", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721433", "species_10721431" ], "products": [ "species_10689176", "species_10721438", "species_10721429" ], "modifiers": [ [ "species_10721433", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "DDB_G0281167", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011", "Q54TK0", "DDB_G0281703", "Q86I15", "DDB_G0291011", "Q54DM8", "DDB_G0292120", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54R25", "DDB_G0291011", "Q54F86", "DDB_G0291011", "P0CG80", "DDB_G0291928", "Q54UC0", "DDB_G0281167", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZG5", "DDB_G0291011", "Q54QC7", "DDB_G0291011" ] }, "reaction_10676955": { "compartment": "compartment_70101", "id": "reaction_10676955", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673638" ], "products": [ "species_10673430", "species_10676953" ], "modifiers": [], "additional_components": [ "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "DDB_G0275881", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10710713": { "compartment": "compartment_70101", "id": "reaction_10710713", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710704", "species_29356" ], "products": [ "species_10678140", "species_10710710" ], "modifiers": [ [ "species_10710704", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "O96612", "DDB_G0275021" ] }, "reaction_10685790": { "compartment": "compartment_12045", "id": "reaction_10685790", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_449283", "species_29420" ], "modifiers": [ [ "species_10685787", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10685738": { "compartment": "compartment_70101", "id": "reaction_10685738", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10685735", "catalyst" ] ], "additional_components": [ "Q86B09", "DDB_G0272781", "Q54X03", "DDB_G0279289" ] }, "reaction_10700634": { "compartment": "compartment_7660", "id": "reaction_10700634", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700619" ], "products": [ "species_10698305", "species_10700632" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0292296", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10689669": { "compartment": "compartment_20699", "id": "reaction_10689669", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10689666", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10685695": { "compartment": "compartment_12045", "id": "reaction_10685695", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_162756" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10685692", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10705340": { "compartment": "compartment_2133233", "id": "reaction_10705340", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5684863", "species_113592", "species_29356" ], "products": [ "species_29370", "species_5684869", "species_29372" ], "modifiers": [ [ "species_10705337", "catalyst" ] ], "additional_components": [ "species_1524042", "species_426925", "species_1524042", "species_426925", "DDB_G0291994" ] }, "reaction_10677244": { "compartment": "compartment_12045", "id": "reaction_10677244", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855663", "species_449229" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10677241", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10717918": { "compartment": "compartment_70101", "id": "reaction_10717918", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717916" ], "products": [ "species_10669973", "species_10673551" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "DDB_G0281703", "DDB_G0281703", "DDB_G0281703", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10718833": { "compartment": "compartment_70101", "id": "reaction_10718833", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_10683047", "species_113592" ], "products": [ "species_29370", "species_10718821", "species_29372" ], "modifiers": [ [ "species_10718830", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "Q54TU1", "DDB_G0281541" ] }, "reaction_10677174": { "compartment": "compartment_70101", "id": "reaction_10677174", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_110096", "species_8855657" ], "modifiers": [ [ "species_10677171", "catalyst" ] ], "additional_components": [ "Q556K9", "DDB_G0272588", "Q86K35", "DDB_G0277289", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515", "Q54QB2", "DDB_G0283965", "Q86JM6", "DDB_G0272006" ] }, "reaction_10693457": { "compartment": "compartment_70101", "id": "reaction_10693457", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693453", "species_10693451" ], "products": [ "species_10693455" ], "modifiers": [], "additional_components": [ "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q75K18", "DDB_G0275455", "Q554G7", "DDB_G0275211", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q1ZXE8", "DDB_G0285821", "Q55GL2", "DDB_G0267622", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q556L1", "DDB_G0272590", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q1ZXE8", "DDB_G0285821", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54EP7", "DDB_G0291412", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q554G7", "DDB_G0275211", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q75K18", "DDB_G0275455", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q55GL2", "DDB_G0267622", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700486": { "compartment": "compartment_7660", "id": "reaction_10700486", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10696675" ], "products": [ "species_10698305", "species_10700484" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0287693", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10709672": { "compartment": "compartment_70101", "id": "reaction_10709672", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10670158", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0272566" ] }, "reaction_10717499": { "compartment": "compartment_70101", "id": "reaction_10717499", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717444", "species_10717446" ], "products": [ "species_10717448", "species_10717497" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "Q54VG3", "DDB_G0280347", "Q54IK3", "DDB_G0290547", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q550P6", "DDB_G0277047", "Q54FR5", "DDB_G0290629", "Q54TK0", "DDB_G0281703", "Q54VG3", "DDB_G0280347", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q555G0", "DDB_G0274897", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54I43", "DDB_G0289021", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10721736": { "compartment": "compartment_7660", "id": "reaction_10721736", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721729", "species_10721712", "species_10721706", "species_10703192" ], "products": [ "species_10721731" ], "modifiers": [], "additional_components": [ "DDB_G0272082", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "Q54D06", "DDB_G0292596", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54TK0", "DDB_G0281703", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "Q54D06", "DDB_G0292596", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "B0G105", "DDB_G0272082" ] }, "reaction_10721572": { "compartment": "compartment_984", "id": "reaction_10721572", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10721532" ], "products": [ "species_2197633", "species_10721564" ], "modifiers": [ [ "species_10721569", "catalyst" ] ], "additional_components": [ "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54WG1", "DDB_G0279675", "Q54G06", "DDB_G0290501", "Q54Y02", "DDB_G0278495", "Q55E77", "DDB_G0270488", "DDB_G0276919" ] }, "reaction_10685457": { "compartment": "compartment_1462052", "id": "reaction_10685457", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685454", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10685780": { "compartment": "compartment_17957", "id": "reaction_10685780", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449315", "species_449229" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10716436": { "compartment": "compartment_70101", "id": "reaction_10716436", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10716426" ], "products": [ "species_10716432", "species_29370" ], "modifiers": [], "additional_components": [ "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_29370", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741", "Q55D95", "DDB_G0269736", "Q55BM4", "DDB_G0269190", "Q76NU3", "DDB_G0277493", "Q552J0", "DDB_G0276233", "Q54ER7", "DDB_G0291225", "Q54CL2", "DDB_G0292872", "Q54ES9", "DDB_G0291358", "species_113592", "Q54TD3", "DDB_G0281849", "P36408", "DDB_G0277143", "Q54TH8", "DDB_G0281741" ] }, "reaction_10698263": { "compartment": "compartment_7660", "id": "reaction_10698263", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698249" ], "products": [ "species_10687009" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685703": { "compartment": "compartment_12045", "id": "reaction_10685703", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449221", "species_110614" ], "products": [ "species_449299", "species_110094" ], "modifiers": [ [ "species_10685700", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10710774": { "compartment": "compartment_70101", "id": "reaction_10710774", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701959", "species_10710770" ], "products": [ "species_10710772" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "P90532", "DDB_G0288065", "Q55BI3", "DDB_G0271346" ] }, "reaction_10717864": { "compartment": "compartment_70101", "id": "reaction_10717864", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_113592", "species_10689276" ], "products": [ "species_111294", "species_10717713" ], "modifiers": [ [ "species_10689276", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0270272" ] }, "reaction_10709185": { "compartment": "compartment_7660", "id": "reaction_10709185", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10709180" ], "products": [ "species_10709182", "species_10669917" ], "modifiers": [ [ "species_10709180", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q86KB3", "DDB_G0274207" ] }, "reaction_10685465": { "compartment": "compartment_20699", "id": "reaction_10685465", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10685462", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10700068": { "compartment": "compartment_7660", "id": "reaction_10700068", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700053" ], "products": [ "species_10698305", "species_10700066" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0293168", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10685746": { "compartment": "compartment_17957", "id": "reaction_10685746", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10685743", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10709951": { "compartment": "compartment_17963", "id": "reaction_10709951", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10687208": { "compartment": "compartment_17963", "id": "reaction_10687208", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687149", "species_914003" ], "products": [ "species_10687206", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700701": { "compartment": "compartment_7660", "id": "reaction_10700701", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10690036" ], "products": [ "species_10698305", "species_10700699" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700091": { "compartment": "compartment_7660", "id": "reaction_10700091", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698318" ], "products": [ "species_10698305", "species_10700089" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700359": { "compartment": "compartment_12045", "id": "reaction_10700359", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_4419981" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10700356", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10709911": { "compartment": "compartment_161320", "id": "reaction_10709911", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10709908", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10700546": { "compartment": "compartment_7660", "id": "reaction_10700546", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700537", "species_10698378" ], "products": [ "species_10698305", "species_10700543" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0292130", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10700462": { "compartment": "compartment_7660", "id": "reaction_10700462", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700203" ], "products": [ "species_10698305", "species_10700460" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0281183", "DDB_G0287693", "Q54UA7", "DDB_G0281183", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10719275": { "compartment": "compartment_70101", "id": "reaction_10719275", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719271", "species_10719264", "species_1131164" ], "products": [ "species_10719273" ], "modifiers": [], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570" ] }, "reaction_10700644": { "compartment": "compartment_7660", "id": "reaction_10700644", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700639" ], "products": [ "species_10698305", "species_10700642" ], "modifiers": [ [ "species_10698378", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0272690", "DDB_G0287693", "DDB_G0272690", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10673657": { "compartment": "compartment_70101", "id": "reaction_10673657", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673336", "species_10673638", "species_10673647" ], "products": [ "species_10673649" ], "modifiers": [], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54VZ4", "DDB_G0279997", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q9GS21", "DDB_G0282379", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "Q55AQ9", "DDB_G0271668", "Q54J50", "DDB_G0288295", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q54TK0", "DDB_G0281703", "Q54X53", "DDB_G0279387", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "Q54TW3", "DDB_G0281469", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q553M7", "DDB_G0275881", "P22683", "DDB_G0283393", "Q54E20", "DDB_G0291870", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "Q54Z09", "DDB_G0277975", "P22685", "DDB_G0286501", "Q55CW5", "DDB_G0270984", "P22684", "DDB_G0277907", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54XP6", "DDB_G0278815", "species_29438", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q76P36", "DDB_G0272308", "Q9GS21", "DDB_G0282379", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54MK8", "DDB_G0285881", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54J50", "DDB_G0288295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "Q54TW3", "DDB_G0281469", "P0CG88", "DDB_G0269458", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "P22684", "DDB_G0277907", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q55BN7", "DDB_G0270424", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q55BS9", "DDB_G0270380", "P46793", "DDB_G0276457", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54X51", "DDB_G0279207", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "species_29438", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "Q54NG2", "DDB_G0285277", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "P22683", "DDB_G0283393", "Q54XP6", "DDB_G0278815", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629" ] }, "reaction_10700794": { "compartment": "compartment_7660", "id": "reaction_10700794", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10700746" ], "products": [ "species_10698305", "species_10700792" ], "modifiers": [ [ "species_10698387", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0270418", "DDB_G0287693", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10700185": { "compartment": "compartment_7660", "id": "reaction_10700185", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10698750" ], "products": [ "species_10698305", "species_10700183" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0279509", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10710812": { "compartment": "compartment_70101", "id": "reaction_10710812", "reactome": "R-DDI-6782106", "name": "USP10 deubiquitinates SNX3, CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710805", "species_29356" ], "products": [ "species_10707592", "species_10710809" ], "modifiers": [ [ "species_10710805", "catalyst" ] ], "additional_components": [ "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021", "Q54UN7", "DDB_G0280921", "O96612", "DDB_G0275021" ] }, "reaction_10689661": { "compartment": "compartment_70101", "id": "reaction_10689661", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689657" ], "products": [ "species_10689659" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_915149", "CHEBI:60627", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "species_964740", "P0CG77", "DDB_G0286907", "CHEBI:60629", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "CHEBI:60628" ] }, "reaction_10698392": { "compartment": "compartment_7660", "id": "reaction_10698392", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698360", "species_10698378" ], "products": [ "species_10698305", "species_10698381" ], "modifiers": [ [ "species_10698389", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10698599": { "compartment": "compartment_7660", "id": "reaction_10698599", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10697630" ], "products": [ "species_10698305", "species_10698563" ], "modifiers": [ [ "species_10698596", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0287693", "Q54QR0", "DDB_G0283681", "Q8N0B4", "DDB_G0286189", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q55FZ7", "DDB_G0267886", "Q552D9", "DDB_G0276101", "Q54FE3", "DDB_G0290919", "Q54X37", "DDB_G0279231", "Q54T56", "DDB_G0281991", "Q54I56", "DDB_G0288993", "Q54PA3", "DDB_G0284679", "Q54HN3", "DDB_G0289341" ] }, "reaction_10698300": { "compartment": "compartment_7660", "id": "reaction_10698300", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698296" ], "products": [ "species_10698298" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10677213": { "compartment": "compartment_12045", "id": "reaction_10677213", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855667", "species_449229" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10677210", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10710428": { "compartment": "compartment_70101", "id": "reaction_10710428", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710419", "species_29356" ], "products": [ "species_10707592", "species_10710425" ], "modifiers": [ [ "species_10710419", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617" ] }, "reaction_10710452": { "compartment": "compartment_7660", "id": "reaction_10710452", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710445", "species_113518" ], "products": [ "species_10709060", "species_10710449" ], "modifiers": [ [ "species_10710445", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10719196": { "compartment": "compartment_70101", "id": "reaction_10719196", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10719191" ], "products": [ "species_10707592", "species_10719193" ], "modifiers": [ [ "species_10710400", "catalyst" ] ], "additional_components": [ "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "B0G199", "DDB_G0293770", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "P11467", "DDB_G0290961", "DDB_G0293770" ] }, "reaction_10710405": { "compartment": "compartment_70101", "id": "reaction_10710405", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710396", "species_29356" ], "products": [ "species_10707592", "species_10710398" ], "modifiers": [ [ "species_10710396", "catalyst" ] ], "additional_components": [ "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407", "Q556A3", "DDB_G0274795", "Q86L44", "DDB_G0294407" ] }, "reaction_10673667": { "compartment": "compartment_70101", "id": "reaction_10673667", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "products": [ "species_10673294", "species_10673277", "species_72617", "species_10673329", "species_10673334" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0278205", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "DDB_G0286753" ] }, "reaction_10700260": { "compartment": "compartment_7660", "id": "reaction_10700260", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700245" ], "products": [ "species_10698305", "species_10700258" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0283605", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673359": { "compartment": "compartment_70101", "id": "reaction_10673359", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673296", "species_72393" ], "products": [ "species_10673298" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10698243": { "compartment": "compartment_7660", "id": "reaction_10698243", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698225", "species_10687009", "species_29358" ], "products": [ "species_10698240", "species_164121", "species_113541" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10698321": { "compartment": "compartment_7660", "id": "reaction_10698321", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698305", "species_10698240" ], "products": [ "species_10698225", "species_10698318" ], "modifiers": [ [ "species_10698225", "catalyst" ] ], "additional_components": [ "DDB_G0287693", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919" ] }, "reaction_10717914": { "compartment": "compartment_70101", "id": "reaction_10717914", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669975" ], "products": [ "species_10673140", "species_10669975" ], "modifiers": [ [ "species_10717911", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q869U4", "DDB_G0276443", "Q54DT4", "DDB_G0292046", "Q54T48", "DDB_G0282007" ] }, "reaction_10677002": { "compartment": "compartment_70101", "id": "reaction_10677002", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10676998" ], "products": [ "species_10677000" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10676951": { "compartment": "compartment_70101", "id": "reaction_10676951", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676926", "species_10676947" ], "products": [ "species_10676949" ], "modifiers": [], "additional_components": [ "DDB_G0275881", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55FE0", "DDB_G0268574", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q553R3", "DDB_G0275395", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q869N9", "DDB_G0271862", "Q54BM2", "DDB_G0293558", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "Q553M7", "DDB_G0275881", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54G90", "DDB_G0290307", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "P90529", "DDB_G0269146", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "species_29438", "Q1ZXC2", "DDB_G0290745", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10706098": { "compartment": "compartment_70101", "id": "reaction_10706098", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140", "species_29356" ], "products": [ "species_10678140", "species_10678138" ], "modifiers": [ [ "species_10706095", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DI9", "DDB_G0269646" ] }, "reaction_10698483": { "compartment": "compartment_7660", "id": "reaction_10698483", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698376", "species_10698438" ], "products": [ "species_10698305", "species_10698480" ], "modifiers": [ [ "species_10698376", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0285989", "DDB_G0287693", "DDB_G0285989", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693" ] }, "reaction_10717855": { "compartment": "compartment_7660", "id": "reaction_10717855", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10717763", "species_10669917" ], "products": [ "species_10717765", "species_113541" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10710584": { "compartment": "compartment_70101", "id": "reaction_10710584", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710535", "species_29356" ], "products": [ "species_10710581", "species_10678140" ], "modifiers": [ [ "species_10710535", "catalyst" ] ], "additional_components": [ "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54YP8", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54ZW5", "DDB_G0277345", "Q86K46", "DDB_G0293202", "Q86HG9", "DDB_G0278535", "Q55GA0", "DDB_G0293202", "Q54HC6", "DDB_G0289555", "Q54WD3", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54TM7", "DDB_G0281557", "Q55GA8", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q559R2", "DDB_G0272454", "Q54F79", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FD5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "Q86AY4", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q86KX6", "DDB_G0293202" ] }, "reaction_10700105": { "compartment": "compartment_7660", "id": "reaction_10700105", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672384", "species_10698368" ], "products": [ "species_10698305", "species_10700102" ], "modifiers": [ [ "species_10686997", "catalyst" ] ], "additional_components": [ "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0287693", "Q54DV7", "DDB_G0293064", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10717866": { "compartment": "compartment_7660", "id": "reaction_10717866", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717703" ], "products": [ "species_10717763", "species_164121" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q55C16", "DDB_G0270272", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10686910": { "compartment": "compartment_20699", "id": "reaction_10686910", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10686907", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10700741": { "compartment": "compartment_7660", "id": "reaction_10700741", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10699886" ], "products": [ "species_10698305", "species_10700739" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0268024", "DDB_G0287693", "Q55FN5", "DDB_G0268024", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10700532": { "compartment": "compartment_7660", "id": "reaction_10700532", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674988", "species_10698318" ], "products": [ "species_10698305", "species_10700530" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "DDB_G0269406", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677205": { "compartment": "compartment_12045", "id": "reaction_10677205", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500581", "species_8855659" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10677202", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10709123": { "compartment": "compartment_70101", "id": "reaction_10709123", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709118", "species_29356" ], "products": [ "species_10670153", "species_10709120" ], "modifiers": [ [ "species_10709118", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P54201", "DDB_G0291239" ] }, "reaction_10699567": { "compartment": "compartment_7660", "id": "reaction_10699567", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698378", "species_10699553" ], "products": [ "species_10698305", "species_10699556" ], "modifiers": [ [ "species_10699564", "catalyst" ] ], "additional_components": [ "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "DDB_G0293468", "DDB_G0287693", "DDB_G0293468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710662": { "compartment": "compartment_7660", "id": "reaction_10710662", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710657" ], "products": [ "species_10669917", "species_10710659" ], "modifiers": [ [ "species_10710657", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q55EJ1", "DDB_G0268872", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273" ] }, "reaction_10700223": { "compartment": "compartment_7660", "id": "reaction_10700223", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700208" ], "products": [ "species_10698305", "species_10700221" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0284411", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10677236": { "compartment": "compartment_70101", "id": "reaction_10677236", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_29416", "species_8855661" ], "modifiers": [ [ "species_10677233", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10710615": { "compartment": "compartment_7660", "id": "reaction_10710615", "reactome": "R-DDI-5696947", "name": "USP47 deubiquitinates POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710610", "species_113518" ], "products": [ "species_10709060", "species_10710612" ], "modifiers": [ [ "species_10710610", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611", "Q1ZXF2", "DDB_G0284713", "Q54H96", "DDB_G0289611" ] }, "reaction_10685782": { "compartment": "compartment_17957", "id": "reaction_10685782", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449311", "species_449371" ], "modifiers": [ [ "species_10685777", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10673663": { "compartment": "compartment_70101", "id": "reaction_10673663", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673277", "species_10673208", "species_10673272" ], "products": [ "species_10673661" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54UU3", "DDB_G0280823", "Q76P36", "DDB_G0272308", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q75K27", "DDB_G0275473", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "Q54PX9", "DDB_G0284237", "P14132", "DDB_G0289877", "Q54Y41", "DDB_G0278429", "Q54PH8", "DDB_G0284533", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54Q51", "DDB_G0284093", "Q55BY1", "DDB_G0270316", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q54EG3", "DDB_G0291526", "O77082", "DDB_G0286117", "P0CG88", "DDB_G0269458", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P42520", "DDB_G0290141", "Q54E24", "DDB_G0291864", "Q54I41", "DDB_G0289025", "Q54S90", "DDB_G0282601", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54X97", "DDB_G0279109", "Q54CC5", "DDB_G0293052", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "Q54EQ1", "DDB_G0291404", "Q54UD0", "DDB_G0281153", "Q54MT0", "DDB_G0285683", "Q86B20", "DDB_G0272078", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q554U9", "DDB_G0274627", "Q54KZ8", "DDB_G0287005", "Q54C49", "DDB_G0293254", "Q54EQ1", "DDB_G0291404", "Q76P36", "DDB_G0272308", "Q75K27", "DDB_G0275473", "P51405", "DDB_G0272825", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54EG3", "DDB_G0291526", "P0CG88", "DDB_G0269458", "Q54KZ8", "DDB_G0287005", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q03409", "DDB_G0271148", "Q54WM4", "DDB_G0279549", "Q54KI0", "DDB_G0287333", "P0CG79", "DDB_G0282369", "Q54MT0", "DDB_G0285683", "Q54QW1", "DDB_G0283597", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "Q54ZW5", "DDB_G0277345", "Q54MZ5", "DDB_G0285597", "Q54CC5", "DDB_G0293052", "Q54UU3", "DDB_G0280823", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "Q54X97", "DDB_G0279109", "P46793", "DDB_G0276457", "Q54UD0", "DDB_G0281153", "Q54PX9", "DDB_G0284237", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q554U9", "DDB_G0274627", "Q54C49", "DDB_G0293254", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54YJ6", "DDB_G0278205", "Q54TK0", "DDB_G0281703", "Q54X51", "DDB_G0279207", "Q86B20", "DDB_G0272078", "O77082", "DDB_G0286117", "P0CG80", "DDB_G0291928", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q86LA2", "DDB_G0272076", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415" ] }, "reaction_10700351": { "compartment": "compartment_12045", "id": "reaction_10700351", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419987", "species_191362" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10700348", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10685687": { "compartment": "compartment_17957", "id": "reaction_10685687", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10685684", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10687242": { "compartment": "compartment_17963", "id": "reaction_10687242", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10687149" ], "products": [ "species_205687", "species_10687240" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10700789": { "compartment": "compartment_7660", "id": "reaction_10700789", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10700770" ], "products": [ "species_10698305", "species_10700787" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "P90520", "DDB_G0279737", "DDB_G0287693", "Q55BP5", "DDB_G0270418", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10698272": { "compartment": "compartment_7660", "id": "reaction_10698272", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698268" ], "products": [ "species_10698270" ], "modifiers": [ [ "species_10698260", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10685678": { "compartment": "compartment_17957", "id": "reaction_10685678", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449298", "species_449229" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10685670", "catalyst" ], [ "species_10685676", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10687198": { "compartment": "compartment_17963", "id": "reaction_10687198", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10687149" ], "products": [ "species_205687", "species_10687196" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357" ] }, "reaction_10710692": { "compartment": "compartment_7660", "id": "reaction_10710692", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10710685" ], "products": [ "species_10709060", "species_10710689" ], "modifiers": [ [ "species_10710685", "catalyst" ] ], "additional_components": [ "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54C28", "DDB_G0293226", "Q54G37", "DDB_G0290453" ] }, "reaction_10700614": { "compartment": "compartment_7660", "id": "reaction_10700614", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698318", "species_10674568" ], "products": [ "species_10698305", "species_10700612" ], "modifiers": [ [ "species_10698318", "catalyst" ] ], "additional_components": [ "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0276863", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q76NW2", "DDB_G0276863", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886" ] }, "reaction_10673357": { "compartment": "compartment_70101", "id": "reaction_10673357", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10673294" ], "products": [ "species_10673296" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "species_29438", "Q869N9", "DDB_G0271862" ] }, "reaction_10711118": { "compartment": "compartment_70101", "id": "reaction_10711118", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787678", "species_113592" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10711115", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10710386": { "compartment": "compartment_70101", "id": "reaction_10710386", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678140" ], "products": [ "species_10678138" ], "modifiers": [ [ "species_10710383", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0284037" ] }, "reaction_10720401": { "compartment": "compartment_70101", "id": "reaction_10720401", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719649", "species_1131164" ], "products": [ "species_111294", "species_10720396", "species_10720398" ], "modifiers": [ [ "species_10719649", "catalyst" ] ], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169", "B0G172", "DDB_G0290671", "species_1131164", "Q55DQ4", "DDB_G0269570", "Q54FK8", "DDB_G0290829", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q55EF0", "DDB_G0269262", "Q1ZXG2", "DDB_G0294577", "Q54FK4", "DDB_G0290833", "Q54NU2", "DDB_G0284985", "Q54DA7", "DDB_G0292406", "Q54S63", "DDB_G0282651", "P20790", "DDB_G0280043", "Q54FL2", "DDB_G0290783", "P36412", "DDB_G0269238", "P34142", "DDB_G0286553", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q8MXQ2", "DDB_G0275675", "P34141", "DDB_G0291233", "Q552H0", "DDB_G0294571", "Q86JP0", "DDB_G0294583", "B0G172", "DDB_G0290671", "species_1131164", "P34139", "DDB_G0283757", "P36410", "DDB_G0281337", "Q54EW9", "DDB_G0291293", "Q8MYF2", "DDB_G0277441", "Q54S62", "DDB_G0294569", "P36411", "DDB_G0269236", "Q558I0", "DDB_G0272905", "Q1ZXK9", "DDB_G0276007", "O76173", "DDB_G0269174", "Q55FK2", "DDB_G0268068", "Q1ZXB8", "DDB_G0294571", "Q55DQ4", "DDB_G0269570", "Q8T193", "DDB_G0294569", "Q54G48", "DDB_G0290407", "Q86JC8", "DDB_G0275955", "Q54GY8", "DDB_G0289827", "Q54E92", "DDB_G0291738", "P36409", "DDB_G0292268", "Q86JP5", "DDB_G0271980", "Q1ZXN9", "DDB_G0294569", "Q1ZXB9", "DDB_G0290831", "Q54RY4", "DDB_G0282899", "Q55EG6", "DDB_G0268910", "Q54QR3", "DDB_G0283603", "species_29420", "Q54VT9", "DDB_G0280143", "P34140", "DDB_G0277867", "Q54FK7", "DDB_G0290779", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q55ET3", "DDB_G0268760", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "Q559X6", "DDB_G0272138", "Q1ZXE7", "DDB_G0286169" ] }, "reaction_10681376": { "compartment": "compartment_70101", "id": "reaction_10681376", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10681343", "species_29368" ], "products": [ "species_29360", "species_29356", "species_10681364" ], "modifiers": [ [ "species_10681373", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "species_71067", "Q556G4", "DDB_G0272634" ] }, "reaction_10685764": { "compartment": "compartment_12045", "id": "reaction_10685764", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10685761", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10721465": { "compartment": "compartment_70101", "id": "reaction_10721465", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721443", "species_10721445", "species_10721450" ], "products": [ "species_10721452" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54L05", "DDB_G0286991", "P0CG78", "DDB_G0289449", "Q86K32", "DDB_G0277267", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_29420", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54IK1", "DDB_G0288701" ] }, "reaction_10670813": { "compartment": "compartment_7660", "id": "reaction_10670813", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10670825": { "compartment": "compartment_7660", "id": "reaction_10670825", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670672", "species_29358" ], "products": [ "species_113582", "species_10670794" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10670792": { "compartment": "compartment_70101", "id": "reaction_10670792", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670790" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QM6", "DDB_G0283617", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10696253": { "compartment": "compartment_161320", "id": "reaction_10696253", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10724755": { "compartment": "compartment_161320", "id": "reaction_10724755", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_2162224", "species_1678743" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10710763": { "compartment": "compartment_7660", "id": "reaction_10710763", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710740", "species_10669917" ], "products": [ "species_10710760" ], "modifiers": [ [ "species_10710740", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710800": { "compartment": "compartment_7660", "id": "reaction_10710800", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710791", "species_113518" ], "products": [ "species_10710797", "species_10669917" ], "modifiers": [ [ "species_10710791", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10710717": { "compartment": "compartment_7660", "id": "reaction_10710717", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10672165", "species_5688114" ], "products": [ "species_10710715" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54R66", "DDB_G0283365", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710742": { "compartment": "compartment_7660", "id": "reaction_10710742", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710738", "species_10710729" ], "products": [ "species_10709642", "species_10710740" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q551N8", "DDB_G0276481", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481" ] }, "reaction_10710744": { "compartment": "compartment_7660", "id": "reaction_10710744", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710727", "species_10710719" ], "products": [ "species_10710729" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54TY2", "DDB_G0281441", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10710722": { "compartment": "compartment_7660", "id": "reaction_10710722", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6781829", "species_10710715" ], "products": [ "species_10710719", "species_113541" ], "modifiers": [ [ "species_10710715", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257" ] }, "reaction_10683780": { "compartment": "compartment_70101", "id": "reaction_10683780", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_29372", "species_10683777" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10722650": { "compartment": "compartment_984", "id": "reaction_10722650", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10722647", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10684783": { "compartment": "compartment_876", "id": "reaction_10684783", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_70106", "species_428026" ], "modifiers": [ [ "species_10684780", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:90799", "CHEBI:47923", "Q559N7", "DDB_G0272550", "Q559I6", "DDB_G0272550", "Q55G06", "DDB_G0272550" ] }, "reaction_10724565": { "compartment": "compartment_7660", "id": "reaction_10724565", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10724563": { "compartment": "compartment_7660", "id": "reaction_10724563", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674840" ], "products": [ "species_10674840", "species_164121", "species_113541" ], "modifiers": [ [ "species_10673970", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079" ] }, "reaction_10675549": { "compartment": "compartment_7660", "id": "reaction_10675549", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674909" ], "products": [ "species_10675547", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674983": { "compartment": "compartment_7660", "id": "reaction_10674983", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674195" ], "products": [ "species_10674840", "species_113541" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674868": { "compartment": "compartment_7660", "id": "reaction_10674868", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674862" ], "products": [ "species_10674866" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674878": { "compartment": "compartment_7660", "id": "reaction_10674878", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674866" ], "products": [ "species_10674874" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "species_6806881", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q557M8", "DDB_G0273525", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10676040": { "compartment": "compartment_7660", "id": "reaction_10676040", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10675547" ], "products": [ "species_113541", "species_10675584" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674911": { "compartment": "compartment_7660", "id": "reaction_10674911", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10674880" ], "products": [ "species_10674193", "species_10674181", "species_113541", "species_10674110", "species_10674909" ], "modifiers": [ [ "species_10672167", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10674876": { "compartment": "compartment_7660", "id": "reaction_10674876", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674874" ], "products": [ "species_10674195", "species_113541" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10683703": { "compartment": "compartment_17951", "id": "reaction_10683703", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683700", "catalyst" ] ], "additional_components": [ "Q55CT6", "DDB_G0288735", "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10683737": { "compartment": "compartment_17951", "id": "reaction_10683737", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389893", "species_113535" ], "products": [ "species_389894", "species_113575" ], "modifiers": [ [ "species_10683734", "catalyst" ] ], "additional_components": [ "B0G110", "DDB_G0288735", "Q54II1", "DDB_G0288735", "Q54RB0", "DDB_G0283261", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q75JL8", "DDB_G0288735", "species_113596" ] }, "reaction_10683740": { "compartment": "compartment_17951", "id": "reaction_10683740", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389894", "species_141343" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683742": { "compartment": "compartment_17951", "id": "reaction_10683742", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192307", "species_389982" ], "products": [ "species_389996", "species_193465", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10693605": { "compartment": "compartment_70101", "id": "reaction_10693605", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693602", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10680017": { "compartment": "compartment_70101", "id": "reaction_10680017", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_111294" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10671897": { "compartment": "compartment_70101", "id": "reaction_10671897", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671894", "species_29372" ], "products": [ "species_10671858", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10682008": { "compartment": "compartment_17960", "id": "reaction_10682008", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_215573", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10675426", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671298": { "compartment": "compartment_5460", "id": "reaction_10671298", "reactome": "R-DDI-70837", "name": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70829", "species_113526" ], "products": [ "species_70836", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671295", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10723508": { "compartment": "compartment_70101", "id": "reaction_10723508", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10673704": { "compartment": "compartment_70101", "id": "reaction_10673704", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_111627", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_29372", "species_111647" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10723971": { "compartment": "compartment_70101", "id": "reaction_10723971", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10712153": { "compartment": "compartment_70101", "id": "reaction_10712153", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10712150", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10684856": { "compartment": "compartment_70101", "id": "reaction_10684856", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_113592" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10684853", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343" ] }, "reaction_10682020": { "compartment": "compartment_12045", "id": "reaction_10682020", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211892", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686707": { "compartment": "compartment_5460", "id": "reaction_10686707", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_30004" ], "products": [ "species_573404", "species_113526" ], "modifiers": [ [ "species_10671343", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10671725": { "compartment": "compartment_70101", "id": "reaction_10671725", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_29996" ], "products": [ "species_70106", "species_29732", "species_29364", "species_113528" ], "modifiers": [ [ "species_10671722", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10674017": { "compartment": "compartment_70101", "id": "reaction_10674017", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29602", "species_29356" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10698613": { "compartment": "compartment_70101", "id": "reaction_10698613", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698610", "species_71284" ], "products": [ "species_29366", "species_71285", "species_10678886" ], "modifiers": [ [ "species_10698610", "catalyst" ] ], "additional_components": [ "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10711102": { "compartment": "compartment_70101", "id": "reaction_10711102", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671129": { "compartment": "compartment_5460", "id": "reaction_10671129", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517495", "species_113521", "species_113552" ], "products": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29366", "species_29360", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10699261": { "compartment": "compartment_70101", "id": "reaction_10699261", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699205" ], "products": [ "species_110096", "species_10699258" ], "modifiers": [ [ "species_10699205", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10724003": { "compartment": "compartment_70101", "id": "reaction_10724003", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9025012" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10673836": { "compartment": "compartment_70101", "id": "reaction_10673836", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10673833", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671521": { "compartment": "compartment_5460", "id": "reaction_10671521", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10671518", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10723948": { "compartment": "compartment_70101", "id": "reaction_10723948", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693658": { "compartment": "compartment_70101", "id": "reaction_10693658", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629739", "species_29356" ], "products": [ "species_1629753", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10723952": { "compartment": "compartment_70101", "id": "reaction_10723952", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023708", "species_29356" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679959": { "compartment": "compartment_70101", "id": "reaction_10679959", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_76194", "species_29370" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10677355": { "compartment": "compartment_70101", "id": "reaction_10677355", "reactome": "R-DDI-163764", "name": "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29878", "species_29512" ], "products": [ "species_29578", "species_29882" ], "modifiers": [ [ "species_10671760", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10693645": { "compartment": "compartment_70101", "id": "reaction_10693645", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_114520", "species_29372" ], "modifiers": [ [ "species_10693642", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "species_29926", "Q54CH3", "DDB_G0292920" ] }, "reaction_10724042": { "compartment": "compartment_70101", "id": "reaction_10724042", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9027029", "species_29368" ], "products": [ "species_29366", "species_9027326", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723997": { "compartment": "compartment_70101", "id": "reaction_10723997", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024012", "species_29368" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10693628": { "compartment": "compartment_7660", "id": "reaction_10693628", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023935", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10697783": { "compartment": "compartment_70101", "id": "reaction_10697783", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_70106", "species_29602", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10696210": { "compartment": "compartment_70101", "id": "reaction_10696210", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10696207", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671658": { "compartment": "compartment_70101", "id": "reaction_10671658", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10671655", "catalyst" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10683688": { "compartment": "compartment_17951", "id": "reaction_10683688", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389822", "species_113535" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693703": { "compartment": "compartment_12045", "id": "reaction_10693703", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10693700", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "species_74016", "Q54K50", "DDB_G0287649", "Q02158", "DDB_G0292736" ] }, "reaction_10724425": { "compartment": "compartment_17963", "id": "reaction_10724425", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10716913": { "compartment": "compartment_17957", "id": "reaction_10716913", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10716907" ], "products": [ "species_10716911" ], "modifiers": [], "additional_components": [ "species_164991", "CHEBI:61907", "DDB_G0270658", "species_164991", "CHEBI:61907", "Q5FXM5", "DDB_G0270658" ] }, "reaction_10682071": { "compartment": "compartment_17960", "id": "reaction_10682071", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_216620" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10699251": { "compartment": "compartment_70101", "id": "reaction_10699251", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699246" ], "products": [ "species_110096", "species_10699248" ], "modifiers": [ [ "species_10699246", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10723985": { "compartment": "compartment_70101", "id": "reaction_10723985", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10711963": { "compartment": "compartment_5460", "id": "reaction_10711963", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709959", "species_10711952" ], "products": [ "species_10711955", "species_10711950" ], "modifiers": [ [ "species_10711960", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10674313": { "compartment": "compartment_5460", "id": "reaction_10674313", "reactome": "R-DDI-74181", "name": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_73871" ], "products": [ "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10671390": { "compartment": "compartment_70101", "id": "reaction_10671390", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10671387", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10714313": { "compartment": "compartment_70101", "id": "reaction_10714313", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799540", "species_29356" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10714310", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10722598": { "compartment": "compartment_70101", "id": "reaction_10722598", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357660", "species_29356" ], "products": [ "species_70106", "species_8959518", "species_76577", "species_29372" ], "modifiers": [ [ "species_10722595", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10675543": { "compartment": "compartment_12045", "id": "reaction_10675543", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39703", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_143501", "species_76455" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10686661": { "compartment": "compartment_5460", "id": "reaction_10686661", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113557" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10686658", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10709689": { "compartment": "compartment_70101", "id": "reaction_10709689", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_73473", "species_70106", "species_5692249" ], "modifiers": [ [ "species_10709686", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10721205": { "compartment": "compartment_5460", "id": "reaction_10721205", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721196", "species_10721184" ], "products": [ "species_10721182", "species_10721198" ], "modifiers": [ [ "species_10721203", "catalyst" ] ], "additional_components": [ "Q54P40", "DDB_G0284809", "Q54VS1", "DDB_G0280173", "CHEBI:33739", "Q555C8", "DDB_G0274657", "DDB_G0274657", "Q54P40", "DDB_G0284809", "CHEBI:49883", "Q54VS1", "DDB_G0280173", "DDB_G0280889" ] }, "reaction_10721413": { "compartment": "compartment_70101", "id": "reaction_10721413", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10721410", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10673730": { "compartment": "compartment_70101", "id": "reaction_10673730", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73578" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10673727", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10675882": { "compartment": "compartment_70101", "id": "reaction_10675882", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10675879", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10715965": { "compartment": "compartment_17951", "id": "reaction_10715965", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810061", "species_141343", "species_113535" ], "products": [ "species_389843", "species_6810070", "species_113575" ], "modifiers": [ [ "species_10715962", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10671413": { "compartment": "compartment_5460", "id": "reaction_10671413", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113556", "species_113521", "species_113526" ], "products": [ "species_508531", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671410", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10724451": { "compartment": "compartment_17963", "id": "reaction_10724451", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_205683", "species_9605685" ], "products": [ "species_205689", "species_9605661" ], "modifiers": [ [ "species_10724448", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671288": { "compartment": "compartment_5460", "id": "reaction_10671288", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70718" ], "products": [ "species_31649", "species_70799" ], "modifiers": [ [ "species_10671285", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10679946": { "compartment": "compartment_70101", "id": "reaction_10679946", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_196778", "species_111294" ], "modifiers": [ [ "species_10679943", "catalyst" ] ], "additional_components": [ "DDB_G0268566" ] }, "reaction_10674328": { "compartment": "compartment_70101", "id": "reaction_10674328", "reactome": "R-DDI-74241", "name": "ADA catalyzes the deamination of (deoxy)adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_29356" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10674325", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10679969": { "compartment": "compartment_70101", "id": "reaction_10679969", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10679966", "catalyst" ] ], "additional_components": [ "Q54Y51", "DDB_G0278413", "species_76629" ] }, "reaction_10699233": { "compartment": "compartment_70101", "id": "reaction_10699233", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699228" ], "products": [ "species_110096", "species_10699230" ], "modifiers": [ [ "species_10699228", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10710929": { "compartment": "compartment_5460", "id": "reaction_10710929", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10710926", "catalyst" ] ], "additional_components": [ "species_113596", "Q86H28", "DDB_G0275669" ] }, "reaction_10686182": { "compartment": "compartment_70101", "id": "reaction_10686182", "reactome": "R-DDI-453338", "name": "PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686180" ], "products": [ "species_76577", "species_10671835" ], "modifiers": [], "additional_components": [ "species_76577", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "P34114", "DDB_G0291123" ] }, "reaction_10693497": { "compartment": "compartment_70101", "id": "reaction_10693497", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_870330", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10683752": { "compartment": "compartment_17951", "id": "reaction_10683752", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10714363": { "compartment": "compartment_70101", "id": "reaction_10714363", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449701", "species_29356" ], "products": [ "species_31633", "species_29512" ], "modifiers": [ [ "species_10714360", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10680566": { "compartment": "compartment_70101", "id": "reaction_10680566", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10675479": { "compartment": "compartment_17960", "id": "reaction_10675479", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_39417", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_156524" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723977": { "compartment": "compartment_70101", "id": "reaction_10723977", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724007": { "compartment": "compartment_70101", "id": "reaction_10724007", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10721165": { "compartment": "compartment_5668575", "id": "reaction_10721165", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668566", "species_5662670" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10721162", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10693637": { "compartment": "compartment_70101", "id": "reaction_10693637", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10684814": { "compartment": "compartment_70101", "id": "reaction_10684814", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10684811", "catalyst" ] ], "additional_components": [ "DDB_G0272883" ] }, "reaction_10693748": { "compartment": "compartment_17957", "id": "reaction_10693748", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_2564836", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10671078": { "compartment": "compartment_5460", "id": "reaction_10671078", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113559" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10671075", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10685049": { "compartment": "compartment_20699", "id": "reaction_10685049", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428270", "species_429785" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10685046", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10703426": { "compartment": "compartment_5668575", "id": "reaction_10703426", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ], [ "species_10703424", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901", "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10680347": { "compartment": "compartment_70101", "id": "reaction_10680347", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10671753": { "compartment": "compartment_70101", "id": "reaction_10671753", "reactome": "R-DDI-71306", "name": "D-ribulose 5-phosphate <=> ribose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10671750", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10726112": { "compartment": "compartment_70101", "id": "reaction_10726112", "reactome": "R-DDI-9727349", "name": "XDH dehydrogenates xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671880": { "compartment": "compartment_70101", "id": "reaction_10671880", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671860" ], "products": [ "species_10671872" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10686823": { "compartment": "compartment_70101", "id": "reaction_10686823", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10686820", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10680968": { "compartment": "compartment_876", "id": "reaction_10680968", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680926" ], "products": [ "species_10680966" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "Q55DU4", "DDB_G0270882", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_71185", "species_29870", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10693648": { "compartment": "compartment_7660", "id": "reaction_10693648", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10675760": { "compartment": "compartment_70101", "id": "reaction_10675760", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_29370", "species_500088" ], "modifiers": [ [ "species_10675757", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10671328": { "compartment": "compartment_5460", "id": "reaction_10671328", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_70858" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10670934": { "compartment": "compartment_70101", "id": "reaction_10670934", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10670857", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10673994": { "compartment": "compartment_70101", "id": "reaction_10673994", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111584", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29404", "species_111294", "species_76577", "species_113578" ], "modifiers": [ [ "species_10673991", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10709701": { "compartment": "compartment_70101", "id": "reaction_10709701", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29366", "species_29356" ], "products": [ "species_70106", "species_29364", "species_5692433" ], "modifiers": [ [ "species_10709698", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10695694": { "compartment": "compartment_17957", "id": "reaction_10695694", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_2046047", "species_211606", "species_426639" ], "modifiers": [ [ "species_10683479", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10720506": { "compartment": "compartment_17927", "id": "reaction_10720506", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10720503", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10696226": { "compartment": "compartment_70101", "id": "reaction_10696226", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10696205", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10686641": { "compartment": "compartment_5460", "id": "reaction_10686641", "reactome": "R-DDI-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_482807", "species_113581" ], "products": [ "species_482803", "species_113593" ], "modifiers": [ [ "species_10686636", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10675638": { "compartment": "compartment_5460", "id": "reaction_10675638", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10681876": { "compartment": "compartment_984", "id": "reaction_10681876", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352030", "species_351630" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682157": { "compartment": "compartment_17960", "id": "reaction_10682157", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_217315", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10682154", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_29926", "species_113596" ] }, "reaction_10721652": { "compartment": "compartment_70101", "id": "reaction_10721652", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10721649", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10684867": { "compartment": "compartment_70101", "id": "reaction_10684867", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_428126" ], "products": [ "species_29366", "species_9025544", "species_29356" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10695696": { "compartment": "compartment_17957", "id": "reaction_10695696", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046051" ], "modifiers": [ [ "species_10686765", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10723999": { "compartment": "compartment_70101", "id": "reaction_10723999", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10723957": { "compartment": "compartment_70101", "id": "reaction_10723957", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10695732": { "compartment": "compartment_17951", "id": "reaction_10695732", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046047", "species_113535" ], "products": [ "species_2066767", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10723050": { "compartment": "compartment_70101", "id": "reaction_10723050", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_29364", "species_113528", "species_29398" ], "modifiers": [ [ "species_10723047", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671234": { "compartment": "compartment_70101", "id": "reaction_10671234", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_508182", "species_29406" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10671231", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10699196": { "compartment": "compartment_70101", "id": "reaction_10699196", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699191", "species_29410" ], "products": [ "species_110096", "species_10699193" ], "modifiers": [ [ "species_10699191", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10674368": { "compartment": "compartment_70101", "id": "reaction_10674368", "reactome": "R-DDI-74258", "name": "XDH oxidizes xanthine to form urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30064", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30034" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10724001": { "compartment": "compartment_70101", "id": "reaction_10724001", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10671162": { "compartment": "compartment_5460", "id": "reaction_10671162", "reactome": "R-DDI-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10671159", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10686188": { "compartment": "compartment_70101", "id": "reaction_10686188", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671907", "species_29372" ], "products": [ "species_10686186", "species_29548" ], "modifiers": [ [ "species_10671889", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q00766", "DDB_G0281383" ] }, "reaction_10679997": { "compartment": "compartment_70101", "id": "reaction_10679997", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197230" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10679994", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10723963": { "compartment": "compartment_70101", "id": "reaction_10723963", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024781", "species_29356" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10693754": { "compartment": "compartment_7660", "id": "reaction_10693754", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023892", "species_29358" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10723967": { "compartment": "compartment_70101", "id": "reaction_10723967", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10677343": { "compartment": "compartment_7660", "id": "reaction_10677343", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10677337" ], "products": [ "species_10677341" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "species_76577", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683676": { "compartment": "compartment_17951", "id": "reaction_10683676", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193446", "species_141343", "species_113535" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10683673", "catalyst" ] ], "additional_components": [ "Q556W1", "DDB_G0273291", "species_113596" ] }, "reaction_10686149": { "compartment": "compartment_5460", "id": "reaction_10686149", "reactome": "R-DDI-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113521", "species_113588" ], "modifiers": [ [ "species_10671466", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10690281": { "compartment": "compartment_70101", "id": "reaction_10690281", "reactome": "R-DDI-1299507", "name": "Methylthio-ribulose-P = Methylthio-ribose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237107" ], "products": [ "species_1237165" ], "modifiers": [ [ "species_10690061", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10711007": { "compartment": "compartment_70101", "id": "reaction_10711007", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247904", "species_1247942" ], "modifiers": [ [ "species_10711004", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10681902": { "compartment": "compartment_984", "id": "reaction_10681902", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10695730": { "compartment": "compartment_17951", "id": "reaction_10695730", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10683611": { "compartment": "compartment_17947", "id": "reaction_10683611", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_76577", "species_389573" ], "modifiers": [ [ "species_10683608", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10695728": { "compartment": "compartment_17951", "id": "reaction_10695728", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066767", "species_141343" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10676860": { "compartment": "compartment_17957", "id": "reaction_10676860", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113748", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113564", "species_113519", "species_113745" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10688234": { "compartment": "compartment_70101", "id": "reaction_10688234", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_113592" ], "products": [ "species_29370", "species_29390" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10702349": { "compartment": "compartment_70101", "id": "reaction_10702349", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10702346", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "Q54VU3", "DDB_G0280135", "species_74126", "species_29926" ] }, "reaction_10675481": { "compartment": "compartment_17957", "id": "reaction_10675481", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113564", "species_113555", "species_39427", "species_113534" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10683691": { "compartment": "compartment_17951", "id": "reaction_10683691", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_141343", "species_113535" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10683685", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10693572": { "compartment": "compartment_70101", "id": "reaction_10693572", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10710360": { "compartment": "compartment_12045", "id": "reaction_10710360", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_76116", "species_5696116", "species_29356", "species_1497857" ], "modifiers": [ [ "species_10710357", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10695709": { "compartment": "compartment_12045", "id": "reaction_10695709", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046059", "species_2046066", "species_113601" ], "products": [ "species_162743", "species_113564", "species_113519", "species_159751", "species_2046057" ], "modifiers": [ [ "species_10695683", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10679396": { "compartment": "compartment_70101", "id": "reaction_10679396", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10681911": { "compartment": "compartment_984", "id": "reaction_10681911", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629", "species_352030" ], "products": [ "species_109276", "species_351628", "species_352329" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10682079": { "compartment": "compartment_17960", "id": "reaction_10682079", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216547", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10682076", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723983": { "compartment": "compartment_70101", "id": "reaction_10723983", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10724034": { "compartment": "compartment_70101", "id": "reaction_10724034", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10681891": { "compartment": "compartment_70101", "id": "reaction_10681891", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29870", "species_29368" ], "products": [ "species_71112", "species_209849" ], "modifiers": [ [ "species_10681888", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10681909": { "compartment": "compartment_984", "id": "reaction_10681909", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351639", "species_352329" ], "products": [ "species_352036", "species_352331" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10696183": { "compartment": "compartment_12045", "id": "reaction_10696183", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10682068", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723085": { "compartment": "compartment_5460", "id": "reaction_10723085", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113600", "species_29376", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723082", "catalyst" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10721602": { "compartment": "compartment_12045", "id": "reaction_10721602", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10677038", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10698339": { "compartment": "compartment_70101", "id": "reaction_10698339", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698337" ], "products": [ "species_111294", "species_10674851", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10726109": { "compartment": "compartment_70101", "id": "reaction_10726109", "reactome": "R-DDI-9727347", "name": "XDH dehydrogenates hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10719211": { "compartment": "compartment_70101", "id": "reaction_10719211", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10723061": { "compartment": "compartment_5460", "id": "reaction_10723061", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113544" ], "products": [ "species_29376", "species_29362", "species_113557", "species_113529" ], "modifiers": [ [ "species_10723058", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10671715": { "compartment": "compartment_70101", "id": "reaction_10671715", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31467", "species_29356" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10671712", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10686653": { "compartment": "compartment_70101", "id": "reaction_10686653", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_113592", "species_29494", "species_29356" ], "products": [ "species_70106", "species_29370", "species_29404", "species_110614", "species_29372" ], "modifiers": [ [ "species_10686650", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10671318": { "compartment": "compartment_5460", "id": "reaction_10671318", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_31649", "species_70858" ], "modifiers": [ [ "species_10671315", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10693615": { "compartment": "compartment_70101", "id": "reaction_10693615", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10693612", "catalyst" ] ], "additional_components": [ "Q54N49", "DDB_G0285505", "species_29360" ] }, "reaction_10688232": { "compartment": "compartment_70101", "id": "reaction_10688232", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965053", "species_113592" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10698532": { "compartment": "compartment_70101", "id": "reaction_10698532", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3000241" ], "products": [ "species_29366", "species_10698529" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10723981": { "compartment": "compartment_70101", "id": "reaction_10723981", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10671400": { "compartment": "compartment_5460", "id": "reaction_10671400", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113600", "species_29444", "species_113529" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10682460": { "compartment": "compartment_984", "id": "reaction_10682460", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_209818", "species_351626", "species_351629" ], "products": [ "species_109276", "species_351628", "species_351630" ], "modifiers": [ [ "species_10681873", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10671191": { "compartment": "compartment_70101", "id": "reaction_10671191", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10671188", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10698522": { "compartment": "compartment_984", "id": "reaction_10698522", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10698519", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10697451": { "compartment": "compartment_70101", "id": "reaction_10697451", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5357707", "species_29356" ], "products": [ "species_5357652", "species_111294", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10696223": { "compartment": "compartment_70101", "id": "reaction_10696223", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10696220", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10700265": { "compartment": "compartment_5460", "id": "reaction_10700265", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29444", "species_29582" ], "modifiers": [ [ "species_10700262", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10693640": { "compartment": "compartment_17957", "id": "reaction_10693640", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2024002", "species_113519" ], "products": [ "species_2024016", "species_113551" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10710309": { "compartment": "compartment_12045", "id": "reaction_10710309", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_76577", "species_30537" ], "modifiers": [ [ "species_10710306", "catalyst" ] ], "additional_components": [ "Q54K22", "DDB_G0287631", "species_29926" ] }, "reaction_10673698": { "compartment": "compartment_70101", "id": "reaction_10673698", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111628" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10700271": { "compartment": "compartment_70101", "id": "reaction_10700271", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10700269" ], "products": [ "species_111294", "species_76577", "species_10680480" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "DDB_G0288791" ] }, "reaction_10723954": { "compartment": "compartment_70101", "id": "reaction_10723954", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10720818": { "compartment": "compartment_70101", "id": "reaction_10720818", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10680482", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10698619": { "compartment": "compartment_70101", "id": "reaction_10698619", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10678890" ], "products": [ "species_111355", "species_10678886" ], "modifiers": [ [ "species_10678890", "catalyst" ] ], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260" ] }, "reaction_10682098": { "compartment": "compartment_12045", "id": "reaction_10682098", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_113534", "species_113601", "species_213162" ], "products": [ "species_213163", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682458": { "compartment": "compartment_70101", "id": "reaction_10682458", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10682455", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10680568": { "compartment": "compartment_70616", "id": "reaction_10680568", "reactome": "R-DDI-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10680551", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10679324": { "compartment": "compartment_17927", "id": "reaction_10679324", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189411", "species_189461" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10679321", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10691612": { "compartment": "compartment_70101", "id": "reaction_10691612", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_1474179" ], "products": [ "species_29366", "species_29870" ], "modifiers": [ [ "species_10691609", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10696267": { "compartment": "compartment_5460", "id": "reaction_10696267", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162256", "species_2162257" ], "products": [ "species_2162214", "species_159450" ], "modifiers": [ [ "species_10696264", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10682136": { "compartment": "compartment_17960", "id": "reaction_10682136", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159154", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_217269" ], "modifiers": [ [ "species_10682133", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10680561": { "compartment": "compartment_5460", "id": "reaction_10680561", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_200671", "species_113593" ], "products": [ "species_113548", "species_200679", "species_113581" ], "modifiers": [ [ "species_10680558", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10724013": { "compartment": "compartment_70101", "id": "reaction_10724013", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10695777": { "compartment": "compartment_161320", "id": "reaction_10695777", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10684878": { "compartment": "compartment_70101", "id": "reaction_10684878", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10686902": { "compartment": "compartment_20699", "id": "reaction_10686902", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10686899", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10671498": { "compartment": "compartment_5460", "id": "reaction_10671498", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10671495", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120", "species_113596" ] }, "reaction_10696163": { "compartment": "compartment_70101", "id": "reaction_10696163", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:34784", "species_8942209", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10672066": { "compartment": "compartment_70101", "id": "reaction_10672066", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10672063", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q551Y6", "DDB_G0276253", "Q54SI2", "DDB_G0282759" ] }, "reaction_10671912": { "compartment": "compartment_70101", "id": "reaction_10671912", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10671872" ], "products": [ "species_10671909", "species_70113" ], "modifiers": [ [ "species_10671877", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "DDB_G0287569" ] }, "reaction_10671745": { "compartment": "compartment_70101", "id": "reaction_10671745", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10671742", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10672030": { "compartment": "compartment_5460", "id": "reaction_10672030", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113525", "species_70958" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10672027", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10682478": { "compartment": "compartment_70101", "id": "reaction_10682478", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_353106", "species_204635" ], "modifiers": [ [ "species_10682475", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10692500": { "compartment": "compartment_161320", "id": "reaction_10692500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2104997", "species_1605715" ], "products": [ "species_2104995", "species_1605637" ], "modifiers": [ [ "species_10692355", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10675875": { "compartment": "compartment_70101", "id": "reaction_10675875", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_113592", "species_6788778" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "species_109395", "species_76577", "CHEBI:57566", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10677058": { "compartment": "compartment_17957", "id": "reaction_10677058", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714825": { "compartment": "compartment_5460", "id": "reaction_10714825", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10674952": { "compartment": "compartment_70101", "id": "reaction_10674952", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76116", "species_113592" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10674947", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10686709": { "compartment": "compartment_5460", "id": "reaction_10686709", "reactome": "R-DDI-508561", "name": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_70951" ], "products": [ "species_113594", "species_508531" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10722779": { "compartment": "compartment_70101", "id": "reaction_10722779", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10670851", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10697437": { "compartment": "compartment_5460", "id": "reaction_10697437", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697433", "species_113600", "species_113529" ], "products": [ "species_113563", "species_10697431" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "Q54KG7", "DDB_G0287353", "species_31649" ] }, "reaction_10718732": { "compartment": "compartment_7660", "id": "reaction_10718732", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567", "species_9668967" ], "modifiers": [ [ "species_10718729", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "species_29426", "B0G107", "DDB_G0272484" ] }, "reaction_10678919": { "compartment": "compartment_70101", "id": "reaction_10678919", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_174393", "species_113592" ], "products": [ "species_29370", "species_29450", "species_29372" ], "modifiers": [ [ "species_10678916", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "species_29926", "Q54E83", "DDB_G0291756" ] }, "reaction_10693477": { "compartment": "compartment_70101", "id": "reaction_10693477", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_113592" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693474", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q54TI0", "DDB_G0281737", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10680035": { "compartment": "compartment_70101", "id": "reaction_10680035", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197256", "species_29472", "species_113592", "species_29356" ], "products": [ "species_29404", "species_111294", "species_29360", "species_76577" ], "modifiers": [ [ "species_10680032", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10674320": { "compartment": "compartment_5460", "id": "reaction_10674320", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500224", "species_113593" ], "products": [ "species_500222", "species_113581" ], "modifiers": [ [ "species_10674317", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_9731659", "species_109386", "Q54YL2", "DDB_G0278191" ] }, "reaction_10695691": { "compartment": "compartment_12045", "id": "reaction_10695691", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162743", "species_211579", "species_2046056" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10695688", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474", "species_29926" ] }, "reaction_10724428": { "compartment": "compartment_17963", "id": "reaction_10724428", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_205689", "species_9605615" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10684911": { "compartment": "compartment_70101", "id": "reaction_10684911", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428686", "species_428671" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10680200": { "compartment": "compartment_876", "id": "reaction_10680200", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10680197", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10693588": { "compartment": "compartment_7660", "id": "reaction_10693588", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10693585", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10723989": { "compartment": "compartment_70101", "id": "reaction_10723989", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676821": { "compartment": "compartment_70101", "id": "reaction_10676821", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500606", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500608" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710344": { "compartment": "compartment_5460", "id": "reaction_10710344", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10710341", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10723965": { "compartment": "compartment_70101", "id": "reaction_10723965", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_29364", "species_9024768" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10676025": { "compartment": "compartment_70101", "id": "reaction_10676025", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10673723", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54QU9", "DDB_G0283627", "Q54PA9", "DDB_G0284669", "Q75JN8", "DDB_G0272246" ] }, "reaction_10721370": { "compartment": "compartment_70101", "id": "reaction_10721370", "reactome": "R-DDI-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73473", "species_70106", "species_8936443" ], "products": [ "species_29360", "species_29468", "species_29356" ], "modifiers": [ [ "species_10721367", "catalyst" ] ], "additional_components": [ "Q8MYE6", "DDB_G0288165", "Q54YY9", "DDB_G0288165", "CHEBI:21437", "Q55D22", "DDB_G0288165", "Q54NC1", "DDB_G0285399", "Q54JB6", "DDB_G0288165" ] }, "reaction_10674006": { "compartment": "compartment_70101", "id": "reaction_10674006", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_111584" ], "modifiers": [ [ "species_10674001", "catalyst" ], [ "species_10674004", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10670908": { "compartment": "compartment_70101", "id": "reaction_10670908", "reactome": "R-DDI-70355", "name": "GALK1 phosphorylates Gal to Gal1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29590" ], "products": [ "species_29370", "species_30170" ], "modifiers": [ [ "species_10670905", "catalyst" ] ], "additional_components": [ "DDB_G0293982" ] }, "reaction_10693763": { "compartment": "compartment_7660", "id": "reaction_10693763", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10693625", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10724764": { "compartment": "compartment_70101", "id": "reaction_10724764", "reactome": "R-DDI-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10724761", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10710906": { "compartment": "compartment_17951", "id": "reaction_10710906", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693325", "species_113535" ], "products": [ "species_6783877", "species_113575" ], "modifiers": [ [ "species_10710903", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10680546": { "compartment": "compartment_70101", "id": "reaction_10680546", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10680543", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10677056": { "compartment": "compartment_17957", "id": "reaction_10677056", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10677053", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10688530": { "compartment": "compartment_70101", "id": "reaction_10688530", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_977329" ], "products": [ "species_936706", "species_29406" ], "modifiers": [ [ "species_10688527", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10676802": { "compartment": "compartment_17957", "id": "reaction_10676802", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_30373", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_140963" ], "modifiers": [ [ "species_10676799", "catalyst" ] ], "additional_components": [ "Q54H99", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "species_113596" ] }, "reaction_10671798": { "compartment": "compartment_5460", "id": "reaction_10671798", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_29376", "species_70958", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10680053": { "compartment": "compartment_70101", "id": "reaction_10680053", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_73604" ], "products": [ "species_29366", "species_111355" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10715958": { "compartment": "compartment_17951", "id": "reaction_10715958", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10715955", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10679114": { "compartment": "compartment_70101", "id": "reaction_10679114", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_76577", "species_29372" ], "modifiers": [ [ "species_10679111", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10682726": { "compartment": "compartment_5460", "id": "reaction_10682726", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113577", "species_113594" ], "products": [ "species_70951", "species_29406" ], "modifiers": [ [ "species_10682723", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10711203": { "compartment": "compartment_70101", "id": "reaction_10711203", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_29666", "species_76183" ], "modifiers": [ [ "species_10711200", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10704741": { "compartment": "compartment_70101", "id": "reaction_10704741", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426910", "species_29368" ], "products": [ "species_70106", "species_2162232", "species_29356" ], "modifiers": [ [ "species_10704738", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10672020": { "compartment": "compartment_70101", "id": "reaction_10672020", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_113592", "species_29416" ], "products": [ "species_111294", "species_76577", "species_76183" ], "modifiers": [ [ "species_10672017", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10688136": { "compartment": "compartment_70101", "id": "reaction_10688136", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688120", "species_111707" ], "products": [ "species_10688125", "species_29432" ], "modifiers": [ [ "species_10688133", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "species_29426", "Q55FS0", "DDB_G0267980", "Q54X04", "DDB_G0279287" ] }, "reaction_10709886": { "compartment": "compartment_17957", "id": "reaction_10709886", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10709883", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10670844": { "compartment": "compartment_70101", "id": "reaction_10670844", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30533", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10670841", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759" ] }, "reaction_10672002": { "compartment": "compartment_5460", "id": "reaction_10672002", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_113532" ], "products": [ "species_113539", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671999", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10673770": { "compartment": "compartment_70101", "id": "reaction_10673770", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_29370", "species_500828" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "species_109395", "CHEBI:57566", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684957": { "compartment": "compartment_70101", "id": "reaction_10684957", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10722590": { "compartment": "compartment_12045", "id": "reaction_10722590", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959486", "species_8959490" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10722587", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10676096": { "compartment": "compartment_70101", "id": "reaction_10676096", "reactome": "R-DDI-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676093", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10692454": { "compartment": "compartment_70101", "id": "reaction_10692454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_200736" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10692451", "catalyst" ] ], "additional_components": [ "species_71185", "P46794", "DDB_G0267386" ] }, "reaction_10715520": { "compartment": "compartment_5460", "id": "reaction_10715520", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6808499", "species_113563", "species_113521" ], "products": [ "species_113600", "species_200679", "species_29376", "species_113529" ], "modifiers": [ [ "species_10715517", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10693661": { "compartment": "compartment_70101", "id": "reaction_10693661", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10686703": { "compartment": "compartment_5460", "id": "reaction_10686703", "reactome": "R-DDI-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113548", "species_113521", "species_113581" ], "products": [ "species_29896", "species_70744", "species_113593" ], "modifiers": [ [ "species_10671265", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10723975": { "compartment": "compartment_70101", "id": "reaction_10723975", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10680223": { "compartment": "compartment_70101", "id": "reaction_10680223", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10680209" ], "products": [ "species_10680207", "species_198816" ], "modifiers": [ [ "species_10680209", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "species_71185", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185" ] }, "reaction_10717979": { "compartment": "compartment_161320", "id": "reaction_10717979", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_6799594", "species_1678743" ], "modifiers": [ [ "species_10717976", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10675545": { "compartment": "compartment_17960", "id": "reaction_10675545", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40795", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76473", "species_76474" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724271": { "compartment": "compartment_161320", "id": "reaction_10724271", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724258", "species_1605715" ], "products": [ "species_10724262", "species_1605745" ], "modifiers": [ [ "species_10724268", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29418", "Q54L24", "DDB_G0286945", "species_29418", "Q55D50", "DDB_G0269790" ] }, "reaction_10720745": { "compartment": "compartment_70101", "id": "reaction_10720745", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10720742", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10692480": { "compartment": "compartment_70101", "id": "reaction_10692480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_29382", "species_936714", "species_111707" ], "modifiers": [ [ "species_10692474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10674980": { "compartment": "compartment_70101", "id": "reaction_10674980", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76103", "species_75967" ], "products": [ "species_76194", "species_549167" ], "modifiers": [ [ "species_10674977", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10722463": { "compartment": "compartment_70101", "id": "reaction_10722463", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800", "species_30537" ], "products": [ "species_70106", "species_29728", "species_8955759" ], "modifiers": [ [ "species_10670855", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10671252": { "compartment": "compartment_5460", "id": "reaction_10671252", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10671249", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10710331": { "compartment": "compartment_876", "id": "reaction_10710331", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428663" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10710328", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10679372": { "compartment": "compartment_5460", "id": "reaction_10679372", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_159549", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10679369", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10673780": { "compartment": "compartment_70101", "id": "reaction_10673780", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10673777", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10676863": { "compartment": "compartment_70101", "id": "reaction_10676863", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423605", "species_29368" ], "products": [ "species_29366", "species_159211", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10673691": { "compartment": "compartment_70101", "id": "reaction_10673691", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111629", "species_111294" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10721497": { "compartment": "compartment_70101", "id": "reaction_10721497", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869353" ], "products": [ "species_111294", "species_29360" ], "modifiers": [ [ "species_10680014", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10682084": { "compartment": "compartment_17960", "id": "reaction_10682084", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113534", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10682081", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671096": { "compartment": "compartment_70101", "id": "reaction_10671096", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29356" ], "products": [ "species_29498", "species_29514" ], "modifiers": [ [ "species_10671093", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10671707": { "compartment": "compartment_70101", "id": "reaction_10671707", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10671704", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10680536": { "compartment": "compartment_70101", "id": "reaction_10680536", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_200640", "species_29356" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10688230": { "compartment": "compartment_70101", "id": "reaction_10688230", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10688227", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10696171": { "compartment": "compartment_12045", "id": "reaction_10696171", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_2142739", "species_29356" ], "modifiers": [ [ "species_10675538", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10711236": { "compartment": "compartment_5460", "id": "reaction_10711236", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788802", "species_113593" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10711233", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0292730" ] }, "reaction_10723036": { "compartment": "compartment_5460", "id": "reaction_10723036", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_29376", "species_113557" ], "modifiers": [ [ "species_10723033", "catalyst" ] ], "additional_components": [ "Q86I22", "DDB_G0275071", "species_29926" ] }, "reaction_10699305": { "compartment": "compartment_70101", "id": "reaction_10699305", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699303" ], "products": [ "species_10698514" ], "modifiers": [], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T2J9", "DDB_G0271960" ] }, "reaction_10695735": { "compartment": "compartment_17951", "id": "reaction_10695735", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066762", "species_193514" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10671459": { "compartment": "compartment_5460", "id": "reaction_10671459", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113587", "species_113559" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10671456", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10722403": { "compartment": "compartment_70101", "id": "reaction_10722403", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10722400", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "DDB_G0269034" ] }, "reaction_10686147": { "compartment": "compartment_5460", "id": "reaction_10686147", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10671446", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10683581": { "compartment": "compartment_17951", "id": "reaction_10683581", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10683578", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10724011": { "compartment": "compartment_70101", "id": "reaction_10724011", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026034" ], "products": [ "species_29364", "species_9026050" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10724015": { "compartment": "compartment_70101", "id": "reaction_10724015", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_29364", "species_9026046" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10690348": { "compartment": "compartment_5460", "id": "reaction_10690348", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10690324", "species_10690337" ], "products": [ "species_10690345", "species_379697", "species_10690339" ], "modifiers": [ [ "species_10690324", "catalyst" ], [ "species_10690337", "catalyst" ] ], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "CHEBI:33739", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10693736": { "compartment": "compartment_876", "id": "reaction_10693736", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10693733", "catalyst" ] ], "additional_components": [ "species_74016", "Q02158", "DDB_G0292736" ] }, "reaction_10721406": { "compartment": "compartment_70101", "id": "reaction_10721406", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_8938276" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10721403", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10725648": { "compartment": "compartment_70101", "id": "reaction_10725648", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10678991" ], "products": [ "species_10725644" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10693623": { "compartment": "compartment_7660", "id": "reaction_10693623", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10696160": { "compartment": "compartment_70101", "id": "reaction_10696160", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9032038" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10715539": { "compartment": "compartment_70101", "id": "reaction_10715539", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_111353", "species_29356" ], "products": [ "species_70106", "species_29364", "species_113528", "species_197969" ], "modifiers": [ [ "species_10715536", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10671308": { "compartment": "compartment_5460", "id": "reaction_10671308", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10671305", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10682018": { "compartment": "compartment_12045", "id": "reaction_10682018", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211906", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211894" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10693580": { "compartment": "compartment_70101", "id": "reaction_10693580", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693577", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10688160": { "compartment": "compartment_70101", "id": "reaction_10688160", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_71284", "species_29356" ], "products": [ "species_947703", "species_111294", "species_174390", "species_947537" ], "modifiers": [ [ "species_10688157", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q54NM6", "DDB_G0285137" ] }, "reaction_10710887": { "compartment": "compartment_70101", "id": "reaction_10710887", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29450", "species_29708" ], "modifiers": [ [ "species_10710884", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10724005": { "compartment": "compartment_70101", "id": "reaction_10724005", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675640": { "compartment": "compartment_5460", "id": "reaction_10675640", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77313" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10687061": { "compartment": "compartment_5460", "id": "reaction_10687061", "reactome": "R-DDI-880002", "name": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_880046", "species_879997" ], "products": [ "species_113594", "species_880041" ], "modifiers": [ [ "species_10687058", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10685398": { "compartment": "compartment_876", "id": "reaction_10685398", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10685395", "catalyst" ] ], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406" ] }, "reaction_10676087": { "compartment": "compartment_70101", "id": "reaction_10676087", "reactome": "R-DDI-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866401", "species_10673826" ], "products": [ "species_10673820", "species_8866399", "species_29356" ], "modifiers": [ [ "species_10676084", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "P29447", "DDB_G0294489", "Q1ZXE0", "DDB_G0287849", "CHEBI:29034", "Q54Q71", "DDB_G0284071", "P42521", "DDB_G0272616" ] }, "reaction_10684832": { "compartment": "compartment_70101", "id": "reaction_10684832", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428163", "species_428139" ], "products": [ "species_76194", "species_428126" ], "modifiers": [ [ "species_10684819", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10680564": { "compartment": "compartment_70101", "id": "reaction_10680564", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29370", "species_111353", "species_29372" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10671362": { "compartment": "compartment_70101", "id": "reaction_10671362", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10671359", "catalyst" ] ], "additional_components": [ "DDB_G0273081" ] }, "reaction_10673986": { "compartment": "compartment_70101", "id": "reaction_10673986", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500071", "species_113592" ], "products": [ "species_500077", "species_29370" ], "modifiers": [ [ "species_10673983", "catalyst" ] ], "additional_components": [ "CHEBI:57673", "species_113578", "species_29420", "CHEBI:58595", "DDB_G0279001" ] }, "reaction_10674020": { "compartment": "compartment_70101", "id": "reaction_10674020", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111409", "species_419151" ], "products": [ "species_111427", "species_111355" ], "modifiers": [ [ "species_10674014", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10671380": { "compartment": "compartment_70101", "id": "reaction_10671380", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34979", "species_29356" ], "products": [ "species_70106", "species_30158" ], "modifiers": [ [ "species_10671377", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10716922": { "compartment": "compartment_70101", "id": "reaction_10716922", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716918", "species_164991" ], "products": [ "species_10716920" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "species_164991", "Q54GC8", "DDB_G0290237" ] }, "reaction_10674856": { "compartment": "compartment_70101", "id": "reaction_10674856", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111627", "species_76183" ], "products": [ "species_29370", "species_29372", "species_29508" ], "modifiers": [ [ "species_10674853", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418" ] }, "reaction_10710920": { "compartment": "compartment_70101", "id": "reaction_10710920", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_35305" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10710917", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10671686": { "compartment": "compartment_70101", "id": "reaction_10671686", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_29970" ], "products": [ "species_29366", "species_29356", "species_34351" ], "modifiers": [ [ "species_10671683", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10724728": { "compartment": "compartment_17957", "id": "reaction_10724728", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_158602", "species_159149" ], "modifiers": [ [ "species_10724725", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10671619": { "compartment": "compartment_70101", "id": "reaction_10671619", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29506", "species_29406" ], "products": [ "species_31365", "species_29404" ], "modifiers": [ [ "species_10671616", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10714942": { "compartment": "compartment_70101", "id": "reaction_10714942", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8866401" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10714939", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10671106": { "compartment": "compartment_5460", "id": "reaction_10671106", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_113594", "species_517496", "species_113529" ], "products": [ "species_517495", "species_113521", "species_113552" ], "modifiers": [ [ "species_10671103", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "Q54KB7", "DDB_G0287469" ] }, "reaction_10693575": { "compartment": "compartment_70101", "id": "reaction_10693575", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10711211": { "compartment": "compartment_5460", "id": "reaction_10711211", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_6788606" ], "products": [ "species_113525", "species_5696409" ], "modifiers": [ [ "species_10711208", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10671608": { "compartment": "compartment_70101", "id": "reaction_10671608", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10671605", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10674301": { "compartment": "compartment_5460", "id": "reaction_10674301", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73909", "species_70958" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10674298", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10693708": { "compartment": "compartment_70101", "id": "reaction_10693708", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693705", "catalyst" ] ], "additional_components": [ "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "species_29926" ] }, "reaction_10679054": { "compartment": "compartment_70101", "id": "reaction_10679054", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10679051", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:34479", "species_9753685", "CHEBI:8927", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54YN2", "DDB_G0278155", "Q54C73", "DDB_G0293122" ] }, "reaction_10671539": { "compartment": "compartment_5460", "id": "reaction_10671539", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_29376", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10671536", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355" ] }, "reaction_10680025": { "compartment": "compartment_70101", "id": "reaction_10680025", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73566", "species_197238" ], "products": [ "species_113528", "species_111294", "species_197220" ], "modifiers": [ [ "species_10680022", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10683763": { "compartment": "compartment_17951", "id": "reaction_10683763", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10683760", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10685044": { "compartment": "compartment_876", "id": "reaction_10685044", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_429802" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10685041", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10725886": { "compartment": "compartment_70101", "id": "reaction_10725886", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_29370", "species_428203" ], "modifiers": [ [ "species_10684851", "catalyst" ], [ "species_10725884", "inhibitor" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q75JX1", "DDB_G0272350", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "LigandDisplayForward?ligandId=6625", "Q75JX1", "DDB_G0272350", "LigandDisplayForward?ligandId=10641", "Q86KF9", "DDB_G0272522", "LigandDisplayForward?ligandId=10219", "Q54HN2", "DDB_G0289343", "LigandDisplayForward?ligandId=6624" ] }, "reaction_10687082": { "compartment": "compartment_5460", "id": "reaction_10687082", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_113552", "species_893617" ], "modifiers": [ [ "species_10671421", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10725836": { "compartment": "compartment_70101", "id": "reaction_10725836", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674001", "species_9678719" ], "products": [ "species_10674004" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "LigandDisplayForward?ligandId=6842", "LigandDisplayForward?ligandId=6832", "LigandDisplayForward?ligandId=6845", "Q54QQ0", "DDB_G0283701", "LigandDisplayForward?ligandId=6842" ] }, "reaction_10686178": { "compartment": "compartment_5460", "id": "reaction_10686178", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_374064" ], "products": [ "species_113585", "species_374061" ], "modifiers": [ [ "species_10686175", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_29418" ] }, "reaction_10676068": { "compartment": "compartment_70101", "id": "reaction_10676068", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29602", "species_29438", "species_29448" ], "products": [ "species_70106", "species_35141", "species_29372", "species_29420" ], "modifiers": [ [ "species_10676065", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_113578", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "P21900", "DDB_G0285429", "species_29926" ] }, "reaction_10697789": { "compartment": "compartment_70101", "id": "reaction_10697789", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_70106", "species_9731659", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10710603": { "compartment": "compartment_5460", "id": "reaction_10710603", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_6801451", "species_113593" ], "products": [ "species_5389850", "species_113548", "species_113581" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10679344": { "compartment": "compartment_70101", "id": "reaction_10679344", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_113528", "species_189455" ], "modifiers": [ [ "species_10679341", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10679938": { "compartment": "compartment_70101", "id": "reaction_10679938", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111707", "species_196786" ], "products": [ "species_196834", "species_111294", "species_76577" ], "modifiers": [ [ "species_10679935", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10724017": { "compartment": "compartment_70101", "id": "reaction_10724017", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9608444" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10686496": { "compartment": "compartment_70101", "id": "reaction_10686496", "reactome": "R-DDI-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_482627", "species_113592" ], "modifiers": [ [ "species_10686491", "catalyst" ] ], "additional_components": [ "species_29494", "species_500739", "species_29892", "species_110644", "species_30185", "species_30187", "species_29438", "species_110614", "species_29420", "CHEBI:60471", "CHEBI:58369", "CHEBI:58595", "CHEBI:57667", "species_110096", "species_110094", "CHEBI:58593", "P34093", "DDB_G0279911" ] }, "reaction_10674365": { "compartment": "compartment_70101", "id": "reaction_10674365", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29356", "species_83956" ], "products": [ "species_30064", "species_31633" ], "modifiers": [ [ "species_10674362", "catalyst" ] ], "additional_components": [ "species_29426", "Q86AW9", "DDB_G0277743" ] }, "reaction_10696240": { "compartment": "compartment_5460", "id": "reaction_10696240", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162212", "species_2162265" ], "products": [ "species_2162252", "species_2162198", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10723961": { "compartment": "compartment_70101", "id": "reaction_10723961", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024602", "species_29356" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10680508": { "compartment": "compartment_7660", "id": "reaction_10680508", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_200492" ], "products": [ "species_200499", "species_113541" ], "modifiers": [ [ "species_10680505", "catalyst" ] ], "additional_components": [ "species_29426", "Q54IH4", "DDB_G0288757" ] }, "reaction_10671648": { "compartment": "compartment_70101", "id": "reaction_10671648", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10671645", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10687814": { "compartment": "compartment_876", "id": "reaction_10687814", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_71185", "species_29356" ], "products": [ "species_29370", "species_917877", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10723987": { "compartment": "compartment_70101", "id": "reaction_10723987", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024576" ], "products": [ "species_29364", "species_9024577" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10675483": { "compartment": "compartment_17960", "id": "reaction_10675483", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31711", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_29630" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696181": { "compartment": "compartment_70101", "id": "reaction_10696181", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142718" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:6498", "CHEBI:6499", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10698333": { "compartment": "compartment_70101", "id": "reaction_10698333", "reactome": "R-DDI-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_10698327", "species_113592" ], "products": [ "species_10698331", "species_111294", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "Q54KE6", "DDB_G0287377", "Q8T2J9", "DDB_G0271960", "DDB_G0288791" ] }, "reaction_10693566": { "compartment": "compartment_17957", "id": "reaction_10693566", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10693563", "catalyst" ] ], "additional_components": [ "Q54ND5", "DDB_G0285339", "Q54L08", "DDB_G0286993" ] }, "reaction_10688246": { "compartment": "compartment_70101", "id": "reaction_10688246", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965146", "species_29368", "species_29356" ], "products": [ "species_29408", "species_31633", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10690084": { "compartment": "compartment_70101", "id": "reaction_10690084", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237176", "species_29356" ], "products": [ "species_70106", "species_1237155", "species_29372" ], "modifiers": [ [ "species_10690081", "catalyst" ] ], "additional_components": [ "Q55FM6", "DDB_G0268036", "species_29926" ] }, "reaction_10675840": { "compartment": "compartment_70101", "id": "reaction_10675840", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500759", "species_113592" ], "products": [ "species_29370", "species_500761" ], "modifiers": [ [ "species_10675837", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:16704", "species_109395", "species_109402", "Q8T154", "DDB_G0274559" ] }, "reaction_10680494": { "compartment": "compartment_70101", "id": "reaction_10680494", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680482", "species_113592" ], "products": [ "species_29370", "species_10680489" ], "modifiers": [ [ "species_10680491", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_29418", "Q54J08", "DDB_G0288387", "species_29418", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643" ] }, "reaction_10671278": { "compartment": "compartment_5460", "id": "reaction_10671278", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10671275", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10671403": { "compartment": "compartment_5460", "id": "reaction_10671403", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_113526", "species_30176" ], "products": [ "species_113556", "species_113552", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671397", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10696251": { "compartment": "compartment_5460", "id": "reaction_10696251", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162209", "species_2162265" ], "products": [ "species_2162252", "species_2162215", "species_113529" ], "modifiers": [ [ "species_10696237", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10684875": { "compartment": "compartment_70101", "id": "reaction_10684875", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025544", "species_29356" ], "products": [ "species_3632878", "species_428237" ], "modifiers": [ [ "species_10684872", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10675569": { "compartment": "compartment_70101", "id": "reaction_10675569", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76577", "species_29356" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10675566", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10680928": { "compartment": "compartment_70101", "id": "reaction_10680928", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680751", "species_10680924" ], "products": [ "species_10680926" ], "modifiers": [], "additional_components": [ "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_71185", "species_113596", "Q54L96", "DDB_G0286763" ] }, "reaction_10714820": { "compartment": "compartment_5460", "id": "reaction_10714820", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693984", "species_113526" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10714817", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10714931": { "compartment": "compartment_17957", "id": "reaction_10714931", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806656", "species_6806362" ], "modifiers": [ [ "species_10714928", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10675642": { "compartment": "compartment_5460", "id": "reaction_10675642", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_77324" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10678909": { "compartment": "compartment_70101", "id": "reaction_10678909", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174390", "species_29356" ], "products": [ "species_111294", "species_71284", "species_29372" ], "modifiers": [ [ "species_10678906", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_74126", "species_29926" ] }, "reaction_10695699": { "compartment": "compartment_17957", "id": "reaction_10695699", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_162743", "species_2046065", "species_113564", "species_113519", "species_159751" ], "modifiers": [ [ "species_10686757", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10671354": { "compartment": "compartment_5460", "id": "reaction_10671354", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671351", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10673701": { "compartment": "compartment_70101", "id": "reaction_10673701", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29448", "species_111647" ], "products": [ "species_70106", "species_29372", "species_111628" ], "modifiers": [ [ "species_10673695", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10673688": { "compartment": "compartment_70101", "id": "reaction_10673688", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10673685", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10680051": { "compartment": "compartment_70101", "id": "reaction_10680051", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10680048", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10722428": { "compartment": "compartment_5460", "id": "reaction_10722428", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113553", "species_113559" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10722425", "catalyst" ] ], "additional_components": [ "Q54BP5", "DDB_G0293514", "Q54IG0", "DDB_G0293514" ] }, "reaction_10687093": { "compartment": "compartment_70101", "id": "reaction_10687093", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_893599", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10725642": { "compartment": "compartment_70101", "id": "reaction_10725642", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10687811", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q8T686", "DDB_G0289655" ] }, "reaction_10680501": { "compartment": "compartment_5460", "id": "reaction_10680501", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938090", "species_159450" ], "modifiers": [ [ "species_10680498", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10698629": { "compartment": "compartment_5460", "id": "reaction_10698629", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159297", "species_3159274" ], "modifiers": [ [ "species_10698626", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10696138": { "compartment": "compartment_984", "id": "reaction_10696138", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_352327", "species_109276" ], "products": [ "species_2160466", "species_2022135", "species_351629" ], "modifiers": [ [ "species_10696135", "catalyst" ] ], "additional_components": [ "Q54EW2", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B17", "DDB_G0293662", "species_113596", "Q55B19", "DDB_G0293662" ] }, "reaction_10723979": { "compartment": "compartment_70101", "id": "reaction_10723979", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "CHEBI:138616", "CHEBI:138615", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10679334": { "compartment": "compartment_17927", "id": "reaction_10679334", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10679331", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10671581": { "compartment": "compartment_70101", "id": "reaction_10671581", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29870", "species_29368" ], "products": [ "species_29506", "species_71112" ], "modifiers": [ [ "species_10671578", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10690353": { "compartment": "compartment_5460", "id": "reaction_10690353", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690351", "species_113531" ], "products": [ "species_10690324" ], "modifiers": [], "additional_components": [ "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "species_71067", "Q54RP2", "DDB_G0283003" ] }, "reaction_10690098": { "compartment": "compartment_70101", "id": "reaction_10690098", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1247904", "species_29356" ], "products": [ "species_29424", "species_111707" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10693526": { "compartment": "compartment_7660", "id": "reaction_10693526", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10711146": { "compartment": "compartment_17951", "id": "reaction_10711146", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787810", "species_113535" ], "products": [ "species_6787814", "species_113575" ], "modifiers": [ [ "species_10711143", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10699208": { "compartment": "compartment_70101", "id": "reaction_10699208", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699203", "species_29410" ], "products": [ "species_110096", "species_10699205" ], "modifiers": [ [ "species_10699203", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10709111": { "compartment": "compartment_5460", "id": "reaction_10709111", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10709108", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10703158": { "compartment": "compartment_17963", "id": "reaction_10703158", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10703155", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10712054": { "compartment": "compartment_70101", "id": "reaction_10712054", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10712051", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10693739": { "compartment": "compartment_876", "id": "reaction_10693739", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_29356" ], "products": [ "species_1629739", "species_29372" ], "modifiers": [ [ "species_10693673", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10693417": { "compartment": "compartment_161320", "id": "reaction_10693417", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105025", "species_1605715" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10693362", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10699242": { "compartment": "compartment_70101", "id": "reaction_10699242", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699230" ], "products": [ "species_10699240" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10704832": { "compartment": "compartment_70101", "id": "reaction_10704832", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5679042", "species_29356" ], "products": [ "species_29370", "species_5679034", "species_29372" ], "modifiers": [ [ "species_10691218", "catalyst" ] ], "additional_components": [ "species_159160", "species_159149", "species_159160", "species_159149", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10724243": { "compartment": "compartment_70101", "id": "reaction_10724243", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10671571": { "compartment": "compartment_5460", "id": "reaction_10671571", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70955", "species_113596" ], "products": [ "species_71045", "species_29376", "species_31649" ], "modifiers": [ [ "species_10671568", "catalyst" ] ], "additional_components": [ "species_113596", "Q54R47", "DDB_G0283411" ] }, "reaction_10684954": { "compartment": "compartment_70101", "id": "reaction_10684954", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10684951", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10679354": { "compartment": "compartment_70101", "id": "reaction_10679354", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_70106", "species_189464", "species_29356" ], "modifiers": [ [ "species_10679351", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10698535": { "compartment": "compartment_70101", "id": "reaction_10698535", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3000241", "species_29356" ], "products": [ "species_29370", "species_3000125", "species_29372" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10687096": { "compartment": "compartment_70101", "id": "reaction_10687096", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_893615", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ], [ "species_8939576", "inhibitor" ], [ "species_29502", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10724430": { "compartment": "compartment_17963", "id": "reaction_10724430", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10709948", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10671336": { "compartment": "compartment_5460", "id": "reaction_10671336", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10671333", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10682091": { "compartment": "compartment_12045", "id": "reaction_10682091", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211977", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211967" ], "modifiers": [ [ "species_10682088", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10681868": { "compartment": "compartment_70101", "id": "reaction_10681868", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_29366", "species_209785", "species_176667" ], "modifiers": [ [ "species_10681865", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10688113": { "compartment": "compartment_70101", "id": "reaction_10688113", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_947539" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10688110", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10690074": { "compartment": "compartment_70101", "id": "reaction_10690074", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237155", "species_29368" ], "products": [ "species_1237122", "species_29460" ], "modifiers": [ [ "species_10690071", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10671127": { "compartment": "compartment_70101", "id": "reaction_10671127", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29448", "species_113592", "species_29356" ], "products": [ "species_29404", "species_29642", "species_111294", "species_76577" ], "modifiers": [ [ "species_10671124", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10699238": { "compartment": "compartment_70101", "id": "reaction_10699238", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699235" ], "products": [ "species_110096", "species_10699228" ], "modifiers": [ [ "species_10699235", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10703431": { "compartment": "compartment_5668572", "id": "reaction_10703431", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5662678", "species_5668568" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "CHEBI:27404", "species_5662670", "CHEBI:27404", "species_5662670", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10671796": { "compartment": "compartment_5460", "id": "reaction_10671796", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113557", "species_113526" ], "products": [ "species_29376", "species_29362", "species_113559" ], "modifiers": [ [ "species_10671793", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q54C70", "DDB_G0292994", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "P36413", "DDB_G0277847", "species_113596" ] }, "reaction_10674059": { "compartment": "compartment_5460", "id": "reaction_10674059", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10674056", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10709082": { "compartment": "compartment_70101", "id": "reaction_10709082", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690044", "species_29356" ], "products": [ "species_76194", "species_5690064" ], "modifiers": [ [ "species_10709079", "catalyst" ] ], "additional_components": [ "species_164991", "CHEBI:61907", "species_174602", "CHEBI:59554", "C7G041", "DDB_G0295733" ] }, "reaction_10686145": { "compartment": "compartment_5462", "id": "reaction_10686145", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113600", "species_113526" ], "products": [ "species_113563", "species_29362", "species_113529" ], "modifiers": [ [ "species_10686142", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10722332": { "compartment": "compartment_17963", "id": "reaction_10722332", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8953493", "species_8851226" ], "modifiers": [ [ "species_10722329", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10671932": { "compartment": "compartment_70101", "id": "reaction_10671932", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10671929", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_30389", "inhibitor" ], [ "species_29358", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_74126", "species_29926" ] }, "reaction_10680528": { "compartment": "compartment_70101", "id": "reaction_10680528", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10682074": { "compartment": "compartment_12045", "id": "reaction_10682074", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211993", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211952", "species_113564", "species_113519" ], "modifiers": [ [ "species_10675540", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671151": { "compartment": "compartment_70101", "id": "reaction_10671151", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498", "species_113567" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10671148", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q86HN8", "DDB_G0274501", "Q55E85", "DDB_G0269352" ] }, "reaction_10676819": { "compartment": "compartment_70101", "id": "reaction_10676819", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500605", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_500607" ], "modifiers": [ [ "species_10676816", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10710913": { "compartment": "compartment_5460", "id": "reaction_10710913", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10710910", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10724046": { "compartment": "compartment_70101", "id": "reaction_10724046", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024011", "species_29368" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678893": { "compartment": "compartment_70101", "id": "reaction_10678893", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369", "species_10678886" ], "products": [ "species_174390", "species_10678890" ], "modifiers": [ [ "species_10678886", "catalyst" ] ], "additional_components": [ "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_3159260", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10724009": { "compartment": "compartment_70101", "id": "reaction_10724009", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10683603": { "compartment": "compartment_17951", "id": "reaction_10683603", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389537", "species_389615", "species_113535" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10683600", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10703429": { "compartment": "compartment_5668572", "id": "reaction_10703429", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10703411", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_936901" ] }, "reaction_10684902": { "compartment": "compartment_70101", "id": "reaction_10684902", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275", "species_29356" ], "products": [ "species_428694", "species_29372" ], "modifiers": [ [ "species_10684897", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10674338": { "compartment": "compartment_70101", "id": "reaction_10674338", "reactome": "R-DDI-74247", "name": "XDH oxidizes hypoxanthine to form xanthine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29368", "species_29356" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10674335", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10671372": { "compartment": "compartment_70101", "id": "reaction_10671372", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30721", "species_29356" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10671369", "catalyst" ] ], "additional_components": [ "Q86AX3", "DDB_G0277727", "species_29360" ] }, "reaction_10723950": { "compartment": "compartment_70101", "id": "reaction_10723950", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671172": { "compartment": "compartment_5460", "id": "reaction_10671172", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29362", "species_113529", "species_113590" ], "products": [ "species_379717", "species_113526" ], "modifiers": [ [ "species_10671169", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10682291": { "compartment": "compartment_70101", "id": "reaction_10682291", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_265281", "species_29356" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10673806": { "compartment": "compartment_70101", "id": "reaction_10673806", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83928", "species_113592" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10673803", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10671561": { "compartment": "compartment_5460", "id": "reaction_10671561", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29376", "species_29362" ], "modifiers": [ [ "species_10671558", "catalyst" ] ], "additional_components": [ "species_29480", "Q54EW8", "DDB_G0291648", "Q869Y7", "DDB_G0275029", "CHEBI:17460", "Q54JE4", "DDB_G0288127", "species_113596" ] }, "reaction_10720454": { "compartment": "compartment_70101", "id": "reaction_10720454", "reactome": "R-DDI-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720450" ], "products": [ "species_10720452" ], "modifiers": [], "additional_components": [ "species_8874708", "Q54YX3", "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10721392": { "compartment": "compartment_70101", "id": "reaction_10721392", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10721389", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10693651": { "compartment": "compartment_7660", "id": "reaction_10693651", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10699221": { "compartment": "compartment_70101", "id": "reaction_10699221", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699193" ], "products": [ "species_10699213" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10674042": { "compartment": "compartment_70101", "id": "reaction_10674042", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_113592", "species_111292" ], "products": [ "species_70106", "species_29370", "species_111338", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10697435": { "compartment": "compartment_5460", "id": "reaction_10697435", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690345", "species_10697431" ], "products": [ "species_10697433", "species_10690337", "species_113529" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54KG7", "DDB_G0287353", "species_31649", "Q54KG7", "DDB_G0287353", "species_113596", "CHEBI:33738", "Q55GW1", "DDB_G0267486" ] }, "reaction_10701681": { "compartment": "compartment_70101", "id": "reaction_10701681", "reactome": "R-DDI-5223313", "name": "ABCD4:LMBRD1 transports Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239", "species_113592", "species_29356" ], "products": [ "species_29370", "species_3000241", "species_29372" ], "modifiers": [ [ "species_10701678", "catalyst" ] ], "additional_components": [ "Q54W20", "DDB_G0279919", "Q54KD1", "DDB_G0287405" ] }, "reaction_10714347": { "compartment": "compartment_161320", "id": "reaction_10714347", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10714344", "catalyst" ] ], "additional_components": [ "Q1ZXI8", "DDB_G0278651", "species_29426", "Q55ER0", "DDB_G0268994", "Q54KN4", "DDB_G0287231", "Q54YF7", "DDB_G0278259", "Q54YC4", "DDB_G0278653", "P34098", "DDB_G0292206" ] }, "reaction_10724753": { "compartment": "compartment_161320", "id": "reaction_10724753", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2065269", "species_1605715" ], "products": [ "species_2105025", "species_1605658" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10682086": { "compartment": "compartment_12045", "id": "reaction_10682086", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_211855", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_211937" ], "modifiers": [ [ "species_10682015", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671697": { "compartment": "compartment_70101", "id": "reaction_10671697", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34351" ], "products": [ "species_30487", "species_29432" ], "modifiers": [ [ "species_10671694", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10679394": { "compartment": "compartment_70101", "id": "reaction_10679394", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10679351" ], "products": [ "species_29426", "species_10679392" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_190173" ] }, "reaction_10699256": { "compartment": "compartment_70101", "id": "reaction_10699256", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10699253" ], "products": [ "species_10699191", "species_110096" ], "modifiers": [ [ "species_10699253", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926" ] }, "reaction_10696176": { "compartment": "compartment_12045", "id": "reaction_10696176", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29768", "species_29368" ], "products": [ "species_29366", "species_29356", "species_2161753" ], "modifiers": [ [ "species_10696173", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10724757": { "compartment": "compartment_161320", "id": "reaction_10724757", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692395", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10724423": { "compartment": "compartment_17963", "id": "reaction_10724423", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10724420", "catalyst" ] ], "additional_components": [ "Q55FA8", "DDB_G0293768", "Q54PJ9", "DDB_G0293768", "Q54BB7", "DDB_G0293768", "Q54PK0", "DDB_G0293768", "Q54PK3", "DDB_G0284551", "Q54L56", "DDB_G0293768", "Q54RA6", "DDB_G0293768" ] }, "reaction_10675485": { "compartment": "compartment_17960", "id": "reaction_10675485", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_76433", "species_29572" ], "modifiers": [ [ "species_10675476", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671513": { "compartment": "compartment_5460", "id": "reaction_10671513", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70958" ], "products": [ "species_29374", "species_113536", "species_113593" ], "modifiers": [ [ "species_10671510", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10710932": { "compartment": "compartment_5460", "id": "reaction_10710932", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_6784236" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10696197": { "compartment": "compartment_70101", "id": "reaction_10696197", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10696194", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10678954": { "compartment": "compartment_17957", "id": "reaction_10678954", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174932" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10678951", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:32663", "CHEBI:63860", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10714406": { "compartment": "compartment_12045", "id": "reaction_10714406", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76194", "species_76103" ], "modifiers": [ [ "species_10714399", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10684913": { "compartment": "compartment_70101", "id": "reaction_10684913", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10684908", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10709894": { "compartment": "compartment_12045", "id": "reaction_10709894", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10709891", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10671086": { "compartment": "compartment_5460", "id": "reaction_10671086", "reactome": "R-DDI-70555", "name": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113561", "species_29896", "species_113593" ], "products": [ "species_29676", "species_113548", "species_113581" ], "modifiers": [ [ "species_10671083", "catalyst" ], [ "species_30471", "catalyst" ] ], "additional_components": [ "DDB_G0276335" ] }, "reaction_10716029": { "compartment": "compartment_17951", "id": "reaction_10716029", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10716026", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10674970": { "compartment": "compartment_70101", "id": "reaction_10674970", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76108" ], "products": [ "species_76103", "species_29372" ], "modifiers": [ [ "species_10674967", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10685912": { "compartment": "compartment_5460", "id": "reaction_10685912", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10685909", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10690108": { "compartment": "compartment_70101", "id": "reaction_10690108", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1247942", "species_29356" ], "products": [ "species_29370", "species_29404", "species_29372" ], "modifiers": [ [ "species_10690105", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10682289": { "compartment": "compartment_70101", "id": "reaction_10682289", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10680220": { "compartment": "compartment_70101", "id": "reaction_10680220", "reactome": "R-DDI-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_10680207" ], "products": [ "species_29360", "species_10680209" ], "modifiers": [ [ "species_10680217", "catalyst" ] ], "additional_components": [ "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q86L22", "DDB_G0277079", "species_71185", "Q54NC1", "DDB_G0285399", "species_113596" ] }, "reaction_10682255": { "compartment": "compartment_70101", "id": "reaction_10682255", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768", "species_29368" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10712062": { "compartment": "compartment_5460", "id": "reaction_10712062", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798162", "species_9757044" ], "products": [ "species_6798194", "species_9757039" ], "modifiers": [ [ "species_10712059", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10687099": { "compartment": "compartment_70101", "id": "reaction_10687099", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29472", "species_29398" ], "products": [ "species_893598", "species_29432" ], "modifiers": [ [ "species_10687090", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10673790": { "compartment": "compartment_70101", "id": "reaction_10673790", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_29356" ], "products": [ "species_31633", "species_500430" ], "modifiers": [ [ "species_10673787", "catalyst" ] ], "additional_components": [ "CHEBI:17562", "CHEBI:15698", "CHEBI:16704", "CHEBI:16450", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10706110": { "compartment": "compartment_12045", "id": "reaction_10706110", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5689006", "species_29356" ], "products": [ "species_5688995", "species_5689001" ], "modifiers": [ [ "species_10706107", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10693680": { "compartment": "compartment_876", "id": "reaction_10693680", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994170", "species_29356" ], "products": [ "species_994123", "species_29372" ], "modifiers": [ [ "species_10693677", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187" ] }, "reaction_10692503": { "compartment": "compartment_161320", "id": "reaction_10692503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2105012", "species_1605715" ], "products": [ "species_1605658", "species_2105010" ], "modifiers": [ [ "species_10692393", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "P13723", "DDB_G0287033", "Q54MU9", "DDB_G0285647", "Q54K56", "DDB_G0287659" ] }, "reaction_10682468": { "compartment": "compartment_70101", "id": "reaction_10682468", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10724731": { "compartment": "compartment_17957", "id": "reaction_10724731", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10677009", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10671242": { "compartment": "compartment_5460", "id": "reaction_10671242", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_113552", "species_508181" ], "modifiers": [ [ "species_10671239", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29588", "CHEBI:57762", "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10683593": { "compartment": "compartment_17951", "id": "reaction_10683593", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10683590", "catalyst" ] ], "additional_components": [ "species_29480", "Q54DA9", "DDB_G0292402", "species_29926" ] }, "reaction_10693745": { "compartment": "compartment_7660", "id": "reaction_10693745", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023940", "species_29358" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10671995": { "compartment": "compartment_70101", "id": "reaction_10671995", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_73473", "species_29510" ], "modifiers": [ [ "species_10671992", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10671638": { "compartment": "compartment_70101", "id": "reaction_10671638", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31365", "species_29368" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10671635", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "species_71067", "species_198816", "Q557J8", "DDB_G0273429" ] }, "reaction_10698616": { "compartment": "compartment_70101", "id": "reaction_10698616", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_10698527", "species_3149505" ], "products": [ "species_29366", "species_10698529", "species_1130611" ], "modifiers": [ [ "species_10698527", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10702271": { "compartment": "compartment_70101", "id": "reaction_10702271", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5423629", "species_29368" ], "products": [ "species_5423657", "species_29366", "species_29356" ], "modifiers": [ [ "species_10675474", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10719223": { "compartment": "compartment_70101", "id": "reaction_10719223", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10714960": { "compartment": "compartment_5460", "id": "reaction_10714960", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807477", "species_113593" ], "products": [ "species_113548", "species_113600", "species_113581", "species_113529" ], "modifiers": [ [ "species_10714957", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10675877": { "compartment": "compartment_70101", "id": "reaction_10675877", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6788778" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10675872", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10687069": { "compartment": "compartment_5460", "id": "reaction_10687069", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687066", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_113527", "catalyst" ], [ "species_880067", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10724039": { "compartment": "compartment_70101", "id": "reaction_10724039", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9024011", "species_29368" ], "products": [ "species_9027049", "species_29366", "species_29356" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10696186": { "compartment": "compartment_70101", "id": "reaction_10696186", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10696157", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "species_71067", "Q54W35", "DDB_G0279909" ] }, "reaction_10688519": { "compartment": "compartment_70101", "id": "reaction_10688519", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_200736", "species_29372" ], "modifiers": [ [ "species_10688516", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10674355": { "compartment": "compartment_70101", "id": "reaction_10674355", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500120" ], "products": [ "species_500118", "species_29372" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "species_29602", "CHEBI:57673", "species_9731659", "species_113578", "CHEBI:28997", "species_83921", "CHEBI:17172", "CHEBI:16750", "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10674782": { "compartment": "compartment_70101", "id": "reaction_10674782", "reactome": "R-DDI-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500006", "species_29370" ], "products": [ "species_113592", "species_500009" ], "modifiers": [ [ "species_10673675", "catalyst" ] ], "additional_components": [ "species_110096", "species_110094", "CHEBI:58593", "species_109395", "CHEBI:57566", "species_109402", "DDB_G0287495" ] }, "reaction_10724032": { "compartment": "compartment_70101", "id": "reaction_10724032", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10724029", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10688148": { "compartment": "compartment_70101", "id": "reaction_10688148", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947496", "species_947561", "species_113592", "species_29356" ], "products": [ "species_111294", "species_76577", "species_947539" ], "modifiers": [ [ "species_10688145", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10723969": { "compartment": "compartment_70101", "id": "reaction_10723969", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024893", "species_29356" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10696146": { "compartment": "compartment_70101", "id": "reaction_10696146", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10671969": { "compartment": "compartment_70101", "id": "reaction_10671969", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29510", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_29416" ], "modifiers": [ [ "species_10671966", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10680345": { "compartment": "compartment_876", "id": "reaction_10680345", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10680342", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10697786": { "compartment": "compartment_70101", "id": "reaction_10697786", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_70106", "species_111584", "species_111294" ], "modifiers": [ [ "species_10697780", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10687079": { "compartment": "compartment_70616", "id": "reaction_10687079", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10687076", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10683622": { "compartment": "compartment_17951", "id": "reaction_10683622", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389664", "species_389678" ], "products": [ "species_193446", "species_389680" ], "modifiers": [ [ "species_10683619", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10673846": { "compartment": "compartment_7660", "id": "reaction_10673846", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742", "species_9668967" ], "modifiers": [ [ "species_10673843", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10698355": { "compartment": "compartment_5460", "id": "reaction_10698355", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10698352", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10712045": { "compartment": "compartment_5460", "id": "reaction_10712045", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6798194", "species_113521", "species_113526" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10671408", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10679382": { "compartment": "compartment_5460", "id": "reaction_10679382", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_189444", "species_113529" ], "modifiers": [ [ "species_10679379", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10723088": { "compartment": "compartment_70101", "id": "reaction_10723088", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10701265", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10725646": { "compartment": "compartment_70101", "id": "reaction_10725646", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725644" ], "products": [ "species_189386", "species_10678991" ], "modifiers": [], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632" ] }, "reaction_10723945": { "compartment": "compartment_70101", "id": "reaction_10723945", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020602", "species_29368" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10678931": { "compartment": "compartment_70101", "id": "reaction_10678931", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71285", "species_29356" ], "products": [ "species_174369", "species_83909" ], "modifiers": [ [ "species_10678928", "catalyst" ] ], "additional_components": [ "P10819", "DDB_G0267418", "species_29360" ] }, "reaction_10698646": { "compartment": "compartment_70101", "id": "reaction_10698646", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698608", "species_3149479" ], "products": [ "species_10698610" ], "modifiers": [], "additional_components": [ "species_29426", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "Q54P92", "DDB_G0284699", "species_113596" ] }, "reaction_10674028": { "compartment": "compartment_70101", "id": "reaction_10674028", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_70106", "species_29370", "species_111370", "species_29372" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680269": { "compartment": "compartment_70616", "id": "reaction_10680269", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10680266", "catalyst" ] ], "additional_components": [ "Q551X6", "DDB_G0276261", "Q54EV4", "DDB_G0291312", "Q54DU1", "DDB_G0292034", "Q54QI8", "DDB_G0283811", "Q54MZ4", "DDB_G0285599" ] }, "reaction_10719220": { "compartment": "compartment_70101", "id": "reaction_10719220", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10719217", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10693757": { "compartment": "compartment_7660", "id": "reaction_10693757", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023922", "species_29358" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10693523", "catalyst" ] ], "additional_components": [ "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0278739", "Q55AP4", "DDB_G0293860", "Q54B75", "DDB_G0293860" ] }, "reaction_10722474": { "compartment": "compartment_70101", "id": "reaction_10722474", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_29370", "species_73578" ], "modifiers": [ [ "species_10722471", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10724048": { "compartment": "compartment_70101", "id": "reaction_10724048", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10671678": { "compartment": "compartment_70101", "id": "reaction_10671678", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29500" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10671675", "catalyst" ] ], "additional_components": [ "Q55DB4", "DDB_G0269714", "species_71185" ] }, "reaction_10682013": { "compartment": "compartment_12045", "id": "reaction_10682013", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10682010", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10723991": { "compartment": "compartment_70101", "id": "reaction_10723991", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10696203", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909" ] }, "reaction_10702273": { "compartment": "compartment_70101", "id": "reaction_10702273", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78587", "CHEBI:78581", "Q54GA9", "DDB_G0290291" ] }, "reaction_10675822": { "compartment": "compartment_5460", "id": "reaction_10675822", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500822", "species_113593" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10675819", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_500742", "species_109366", "CHEBI:57566", "DDB_G0278191" ] }, "reaction_10719226": { "compartment": "compartment_70101", "id": "reaction_10719226", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_70106", "species_29370", "species_8869353" ], "modifiers": [ [ "species_10719208", "catalyst" ] ], "additional_components": [ "Q9GNF0", "DDB_G0271146", "Q55EL3", "DDB_G0269034" ] }, "reaction_10721331": { "compartment": "compartment_70616", "id": "reaction_10721331", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10721320" ], "products": [ "species_29374", "species_10721323" ], "modifiers": [ [ "species_10721328", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10682331": { "compartment": "compartment_70101", "id": "reaction_10682331", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281", "species_29356" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10682328", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10711938": { "compartment": "compartment_5460", "id": "reaction_10711938", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709957", "species_10711922" ], "products": [ "species_10709959", "species_10711930" ], "modifiers": [ [ "species_10711935", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287773", "Q869Y7", "DDB_G0275029", "Q54C70", "DDB_G0292994", "Q54VG0", "DDB_G0280353", "Q86AD5", "DDB_G0271564", "Q86HX0", "DDB_G0276417", "Q54JE4", "DDB_G0288127", "species_113596", "species_29480", "Q54EW8", "DDB_G0291648", "CHEBI:17460", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "P36413", "DDB_G0277847", "Q54M22", "DDB_G0286335", "DDB_G0287107" ] }, "reaction_10671117": { "compartment": "compartment_5460", "id": "reaction_10671117", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113552", "species_113587" ], "modifiers": [ [ "species_10671114", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10725639": { "compartment": "compartment_70101", "id": "reaction_10725639", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10703403": { "compartment": "compartment_5668572", "id": "reaction_10703403", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10703400", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10696248": { "compartment": "compartment_70616", "id": "reaction_10696248", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10696245", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10725998": { "compartment": "compartment_70101", "id": "reaction_10725998", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_197965" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10725995", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10714822": { "compartment": "compartment_5460", "id": "reaction_10714822", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5389850", "species_113548", "species_113581" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10710600", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10684864": { "compartment": "compartment_70101", "id": "reaction_10684864", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_29368", "species_428126" ], "products": [ "species_29356", "species_428218", "species_428256" ], "modifiers": [ [ "species_10684861", "catalyst" ] ], "additional_components": [ "species_29364", "species_192305", "species_29366", "species_29360", "DDB_G0269738" ] }, "reaction_10674036": { "compartment": "compartment_70101", "id": "reaction_10674036", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111354", "species_29472", "species_113592", "species_29356" ], "products": [ "species_70106", "species_29370", "species_111369", "species_29404", "species_29372" ], "modifiers": [ [ "species_10674033", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10698347": { "compartment": "compartment_5460", "id": "reaction_10698347", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_2162257", "species_189444" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10698344", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10696168": { "compartment": "compartment_12045", "id": "reaction_10696168", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_140356", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10696165", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10682321": { "compartment": "compartment_876", "id": "reaction_10682321", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10682318", "catalyst" ] ], "additional_components": [ "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10675770": { "compartment": "compartment_70101", "id": "reaction_10675770", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500201" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10673767", "catalyst" ] ], "additional_components": [ "CHEBI:17256", "CHEBI:17172", "CHEBI:57673", "species_109386", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10684070": { "compartment": "compartment_876", "id": "reaction_10684070", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10684067", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10723505": { "compartment": "compartment_70101", "id": "reaction_10723505", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29382", "species_29398", "species_29356" ], "modifiers": [ [ "species_10723502", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10683783": { "compartment": "compartment_17947", "id": "reaction_10683783", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10683481", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10679390": { "compartment": "compartment_70101", "id": "reaction_10679390", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10679387", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10699265": { "compartment": "compartment_70101", "id": "reaction_10699265", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699258" ], "products": [ "species_10699263" ], "modifiers": [ [ "species_10699218", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "DDB_G0274105" ] }, "reaction_10678959": { "compartment": "compartment_17957", "id": "reaction_10678959", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174384", "species_174911" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10678956", "catalyst" ] ], "additional_components": [ "CHEBI:16580", "species_211993", "species_29630", "species_159559", "species_39427", "CHEBI:32649", "species_158604", "CHEBI:65137", "CHEBI:176976", "CHEBI:64681", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10671668": { "compartment": "compartment_70101", "id": "reaction_10671668", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29586", "species_29666" ], "modifiers": [ [ "species_10671665", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10721317": { "compartment": "compartment_70101", "id": "reaction_10721317", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10721306", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10714397": { "compartment": "compartment_70101", "id": "reaction_10714397", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10714391", "catalyst" ] ], "additional_components": [ "Q54N57", "DDB_G0285489", "Q54DT3", "DDB_G0292048" ] }, "reaction_10715501": { "compartment": "compartment_13977", "id": "reaction_10715501", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_6808468" ], "products": [ "species_70106", "species_73473", "species_2453691" ], "modifiers": [ [ "species_10715498", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10711244": { "compartment": "compartment_7660", "id": "reaction_10711244", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788813", "species_29358" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10711241", "catalyst" ] ], "additional_components": [ "species_109395", "species_76577", "CHEBI:57566", "species_109386", "species_29370", "species_110094", "CHEBI:57667", "CHEBI:58593", "DDB_G0278493" ] }, "reaction_10671068": { "compartment": "compartment_70101", "id": "reaction_10671068", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10671065", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10720456": { "compartment": "compartment_70101", "id": "reaction_10720456", "reactome": "R-DDI-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874708", "species_10720448" ], "products": [ "species_10720450" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_8874708", "Q54YX3", "DDB_G0278031" ] }, "reaction_10691374": { "compartment": "compartment_70101", "id": "reaction_10691374", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10691371", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10724050": { "compartment": "compartment_70101", "id": "reaction_10724050", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10723943": { "compartment": "compartment_70101", "id": "reaction_10723943", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020474", "species_29368" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10670918": { "compartment": "compartment_70101", "id": "reaction_10670918", "reactome": "R-DDI-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10670915", "catalyst" ] ], "additional_components": [ "Q553X7", "DDB_G0275295", "species_29360" ] }, "reaction_10709876": { "compartment": "compartment_17957", "id": "reaction_10709876", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_5693711", "species_156540", "species_5693712" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10679064": { "compartment": "compartment_17957", "id": "reaction_10679064", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10679061", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:27561", "species_159211", "CHEBI:2505", "species_9753685", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10709696": { "compartment": "compartment_12045", "id": "reaction_10709696", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29356", "species_428671" ], "products": [ "species_70106", "species_73473", "species_3632881" ], "modifiers": [ [ "species_10709693", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10714952": { "compartment": "compartment_5460", "id": "reaction_10714952", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10714949", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10688509": { "compartment": "compartment_17951", "id": "reaction_10688509", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10688506", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10693760": { "compartment": "compartment_70101", "id": "reaction_10693760", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994123", "species_29356" ], "products": [ "species_1629746", "species_29372" ], "modifiers": [ [ "species_10693655", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10674382": { "compartment": "compartment_70101", "id": "reaction_10674382", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500244", "species_83962" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10674379", "catalyst" ] ], "additional_components": [ "species_112016", "CHEBI:58576", "CHEBI:16704", "CHEBI:16450", "Q54PM8", "DDB_G0284431" ] }, "reaction_10688244": { "compartment": "compartment_70101", "id": "reaction_10688244", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964952", "species_29368" ], "products": [ "species_29408", "species_29390" ], "modifiers": [ [ "species_10688241", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10680007": { "compartment": "compartment_70101", "id": "reaction_10680007", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10680004", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10698644": { "compartment": "compartment_70101", "id": "reaction_10698644", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_965131", "species_29368", "species_29356" ], "products": [ "species_29408", "species_3204324" ], "modifiers": [ [ "species_10698641", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "Q54FB7", "DDB_G0291047", "species_113596" ] }, "reaction_10693548": { "compartment": "compartment_70101", "id": "reaction_10693548", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994146" ], "products": [ "species_1629741", "species_29372" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10715863": { "compartment": "compartment_17951", "id": "reaction_10715863", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389620", "species_141343", "species_192305" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10715860", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10684933": { "compartment": "compartment_984", "id": "reaction_10684933", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10684930", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10693569": { "compartment": "compartment_70101", "id": "reaction_10693569", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10693545", "catalyst" ] ], "additional_components": [ "Q55D87", "DDB_G0269746", "species_29926" ] }, "reaction_10720464": { "compartment": "compartment_5460", "id": "reaction_10720464", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113539", "species_113593" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10720461", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10684725": { "compartment": "compartment_876", "id": "reaction_10684725", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_351626" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10684722", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10686646": { "compartment": "compartment_876", "id": "reaction_10686646", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10686643", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10675490": { "compartment": "compartment_12045", "id": "reaction_10675490", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76328", "species_156540", "species_113601", "species_113534" ], "products": [ "species_113564", "species_113519", "species_76452" ], "modifiers": [ [ "species_10675487", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10674039": { "compartment": "compartment_70101", "id": "reaction_10674039", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_70106", "species_111354", "species_111355" ], "modifiers": [ [ "species_10674025", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10680570": { "compartment": "compartment_70101", "id": "reaction_10680570", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200640", "species_29356" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10680525", "catalyst" ] ], "additional_components": [ "Q54VK0", "DDB_G0283121", "Q54RI8", "DDB_G0283121" ] }, "reaction_10680556": { "compartment": "compartment_70101", "id": "reaction_10680556", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_200665" ], "products": [ "species_29370", "species_174404", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10693664": { "compartment": "compartment_70101", "id": "reaction_10693664", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629753", "species_29356" ], "products": [ "species_426910", "species_29372" ], "modifiers": [ [ "species_10693494", "catalyst" ] ], "additional_components": [ "Q54U72", "DDB_G0281239", "species_29926" ] }, "reaction_10680533": { "compartment": "compartment_876", "id": "reaction_10680533", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10680530", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10680239": { "compartment": "compartment_70101", "id": "reaction_10680239", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10680231" ], "products": [ "species_10674902", "species_158466" ], "modifiers": [ [ "species_10680236", "catalyst" ] ], "additional_components": [ "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "Q869W9", "DDB_G0275069", "Q55E72", "DDB_G0269364", "Q869X2", "DDB_G0275077", "DDB_G0285927" ] }, "reaction_10696179": { "compartment": "compartment_70101", "id": "reaction_10696179", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142738", "species_29368" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10682252", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "species_74016", "Q54W35", "DDB_G0279909", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10670982": { "compartment": "compartment_70101", "id": "reaction_10670982", "reactome": "R-DDI-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30014" ], "modifiers": [ [ "species_10670979", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_113592", "inhibitor" ], [ "species_76190", "inhibitor" ] ], "additional_components": [ "P90521", "DDB_G0274111" ] }, "reaction_10680043": { "compartment": "compartment_70101", "id": "reaction_10680043", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29404", "species_111355" ], "products": [ "species_29370", "species_197969", "species_29372" ], "modifiers": [ [ "species_10680040", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10675644": { "compartment": "compartment_5460", "id": "reaction_10675644", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10671325", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10674311": { "compartment": "compartment_5460", "id": "reaction_10674311", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_73909", "species_113559" ], "modifiers": [ [ "species_10674308", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10682486": { "compartment": "compartment_70101", "id": "reaction_10682486", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10682483", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10670870": { "compartment": "compartment_70101", "id": "reaction_10670870", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_29548" ], "products": [ "species_29410", "species_111294" ], "modifiers": [ [ "species_10670867", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10671223": { "compartment": "compartment_5460", "id": "reaction_10671223", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_508181", "species_113526" ], "products": [ "species_29376", "species_29362", "species_508261" ], "modifiers": [ [ "species_10671220", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:16530", "CHEBI:17865", "species_70851", "species_70718", "species_70715", "species_29480", "Q54EW8", "DDB_G0291648", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_113596", "Q54M22", "DDB_G0286335" ] }, "reaction_10691385": { "compartment": "compartment_70101", "id": "reaction_10691385", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10691382", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10671441": { "compartment": "compartment_5460", "id": "reaction_10671441", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938", "species_113526" ], "products": [ "species_113594", "species_29376", "species_29362", "species_113529" ], "modifiers": [ [ "species_10671438", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q54B68", "DDB_G0293872", "Q55BI2", "DDB_G0271344", "species_29418" ] }, "reaction_10702283": { "compartment": "compartment_70101", "id": "reaction_10702283", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_5490231", "species_2022890" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "CHEBI:78585", "CHEBI:78580", "CHEBI:78578", "CHEBI:78583", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10723959": { "compartment": "compartment_70101", "id": "reaction_10723959", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10683750": { "compartment": "compartment_17951", "id": "reaction_10683750", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10683747", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10723973": { "compartment": "compartment_70101", "id": "reaction_10723973", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024463", "species_29368" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10682096": { "compartment": "compartment_12045", "id": "reaction_10682096", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211939", "species_156540", "species_113601", "species_113534" ], "products": [ "species_211927", "species_113564", "species_113519" ], "modifiers": [ [ "species_10682093", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10717974": { "compartment": "compartment_161320", "id": "reaction_10717974", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10717971", "catalyst" ] ], "additional_components": [ "species_29426", "P34098", "DDB_G0292206" ] }, "reaction_10698294": { "compartment": "compartment_70101", "id": "reaction_10698294", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199207", "species_113592", "species_10698280" ], "products": [ "species_111294", "species_10698286", "species_76577" ], "modifiers": [ [ "species_10698291", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10679956": { "compartment": "compartment_70101", "id": "reaction_10679956", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10679953", "catalyst" ] ], "additional_components": [ "Q55GR8", "DDB_G0267546", "species_29926" ] }, "reaction_10724025": { "compartment": "compartment_70101", "id": "reaction_10724025", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10684976", "catalyst" ] ], "additional_components": [ "CHEBI:137019", "CHEBI:137020", "CHEBI:137018", "CHEBI:137011", "DDB_G0279909" ] }, "reaction_10683754": { "compartment": "compartment_17951", "id": "reaction_10683754", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390249", "species_141343" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10679736", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724044": { "compartment": "compartment_70101", "id": "reaction_10724044", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9027049", "species_29364", "species_29368" ], "products": [ "species_29366", "species_9027324", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10671591": { "compartment": "compartment_70101", "id": "reaction_10671591", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73473", "species_71129" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10671588", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10682470": { "compartment": "compartment_70101", "id": "reaction_10682470", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_76194", "species_353555" ], "modifiers": [ [ "species_10682465", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10699535": { "compartment": "compartment_7660", "id": "reaction_10699535", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_10699531" ], "products": [ "species_10699533" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10685442": { "compartment": "compartment_876", "id": "reaction_10685442", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10685439", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685527": { "compartment": "compartment_70101", "id": "reaction_10685527", "reactome": "R-DDI-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674709", "species_10684045" ], "products": [ "species_10685525" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10685468": { "compartment": "compartment_70101", "id": "reaction_10685468", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683907", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10674822": { "compartment": "compartment_13231", "id": "reaction_10674822", "reactome": "R-DDI-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674810" ], "products": [ "species_10674820" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10674828": { "compartment": "compartment_70101", "id": "reaction_10674828", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674826" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10674824": { "compartment": "compartment_13231", "id": "reaction_10674824", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674806" ], "products": [ "species_10674816" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10720815": { "compartment": "compartment_171062", "id": "reaction_10720815", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720749" ], "products": [ "species_10720472", "species_10720753", "species_29420" ], "modifiers": [ [ "species_10720812", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P34142", "DDB_G0286553", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PZ6", "DDB_G0284213", "Q1ZXD2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258" ] }, "reaction_10721139": { "compartment": "compartment_5668575", "id": "reaction_10721139", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721116", "species_29438" ], "products": [ "species_10720472", "species_10721124", "species_29420" ], "modifiers": [ [ "species_10721136", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MXQ2", "DDB_G0275675", "Q55FM7", "DDB_G0268034", "Q54QR3", "DDB_G0283603", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "species_29438", "Q54QR3", "DDB_G0283603", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10720997": { "compartment": "compartment_17938", "id": "reaction_10720997", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720948" ], "products": [ "species_10720472", "species_10720978", "species_29420" ], "modifiers": [ [ "species_10720994", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q54IQ5", "DDB_G0288589", "Q54TG0", "DDB_G0281773" ] }, "reaction_10720737": { "compartment": "compartment_70101", "id": "reaction_10720737", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720721" ], "products": [ "species_10720472", "species_10720725", "species_29420" ], "modifiers": [ [ "species_10720734", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "P36410", "DDB_G0281337", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10721062": { "compartment": "compartment_13946", "id": "reaction_10721062", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721005" ], "products": [ "species_10720472", "species_10721035", "species_29420" ], "modifiers": [ [ "species_10721059", "catalyst" ] ], "additional_components": [ "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q54EW9", "DDB_G0291293", "Q55FM7", "DDB_G0268034", "species_29420", "Q54VT9", "DDB_G0280143", "Q558I0", "DDB_G0272905", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "Q552K3", "DDB_G0275969", "P34141", "DDB_G0291233", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q54CV2", "DDB_G0292682", "Q54YG5", "DDB_G0278643", "Q556Z3", "DDB_G0273209", "Q54CU7", "DDB_G0292690", "Q54UU1", "DDB_G0280827", "Q555X3", "DDB_G0274803", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q557G3", "DDB_G0273467", "Q54U24", "DDB_G0281351", "Q54RV6", "DDB_G0282887", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135" ] }, "reaction_10720645": { "compartment": "compartment_263163", "id": "reaction_10720645", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720638", "species_29438" ], "products": [ "species_10720642", "species_10720472", "species_29420" ], "modifiers": [ [ "species_10716880", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q55FK2", "DDB_G0268068", "Q55FM7", "DDB_G0268034", "Q55FK2", "DDB_G0268068", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10720634": { "compartment": "compartment_263163", "id": "reaction_10720634", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720551" ], "products": [ "species_10720472", "species_10720603", "species_29420" ], "modifiers": [ [ "species_10720631", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q55FM7", "DDB_G0268034", "species_29420", "P36411", "DDB_G0269236", "Q54VT9", "DDB_G0280143", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54FK7", "DDB_G0290779", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_29438", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q55DD7", "DDB_G0270918", "Q54JA6", "DDB_G0288237" ] }, "reaction_10720942": { "compartment": "compartment_171062", "id": "reaction_10720942", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10720880" ], "products": [ "species_10720472", "species_10720884", "species_29420" ], "modifiers": [ [ "species_10720939", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q8MYF2", "DDB_G0277441", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q8MYF2", "DDB_G0277441", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115" ] }, "reaction_10721156": { "compartment": "compartment_12045", "id": "reaction_10721156", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10721143" ], "products": [ "species_10720472", "species_29420", "species_10721147" ], "modifiers": [ [ "species_10721153", "catalyst" ] ], "additional_components": [ "species_29420", "Q54VT9", "DDB_G0280143", "Q54GY8", "DDB_G0289827", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10722918": { "compartment": "compartment_5460", "id": "reaction_10722918", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722910" ], "products": [], "modifiers": [ [ "species_10722915", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "Q55BQ4", "DDB_G0270806", "Q55CS9", "DDB_G0269916", "Q54U71", "DDB_G0281241", "Q37315", "DDB_G0294016", "DDB_G0271506" ] }, "reaction_10679142": { "compartment": "compartment_7660", "id": "reaction_10679142", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679123", "species_10679128", "species_10679133", "species_10679138" ], "products": [ "species_10679140" ], "modifiers": [], "additional_components": [ "DDB_G0289271", "DDB_G0293564", "DDB_G0291506", "DDB_G0269324", "Q55EA2", "DDB_G0269324", "Q54BL9", "DDB_G0293564", "Q54HR6", "DDB_G0289271", "Q54EH6", "DDB_G0291506" ] }, "reaction_10670519": { "compartment": "compartment_7660", "id": "reaction_10670519", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669631" ], "products": [ "species_10669627", "species_10669598", "species_10669622", "species_10669615" ], "modifiers": [], "additional_components": [ "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "DDB_G0292958", "DDB_G0286623", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10726207": { "compartment": "compartment_7660", "id": "reaction_10726207", "reactome": "R-DDI-9757258", "name": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669598", "species_10669615" ], "products": [ "species_10669617" ], "modifiers": [], "additional_components": [ "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669566": { "compartment": "compartment_7660", "id": "reaction_10669566", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10669561" ], "products": [ "species_10669563", "species_10669557" ], "modifiers": [ [ "species_10669561", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670517": { "compartment": "compartment_70101", "id": "reaction_10670517", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670400" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726203": { "compartment": "compartment_7660", "id": "reaction_10726203", "reactome": "R-DDI-9757256", "name": "MCM3 binds MCM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669627", "species_10669622" ], "products": [ "species_10669629" ], "modifiers": [], "additional_components": [ "DDB_G0292958", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309" ] }, "reaction_10669568": { "compartment": "compartment_7660", "id": "reaction_10669568", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669559", "species_10669535" ], "products": [ "species_10669561" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54RD4", "DDB_G0283189", "Q55BM5", "DDB_G0270442", "Q54Y85", "DDB_G0278367", "Q54MM7", "DDB_G0285853", "Q7KWN0", "DDB_G0272740", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10669647": { "compartment": "compartment_7660", "id": "reaction_10669647", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669573", "species_10669643" ], "products": [ "species_10669645" ], "modifiers": [], "additional_components": [ "DDB_G0267748", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "P34112", "DDB_G0272813", "Q54LI2", "DDB_G0286623", "Q55GA4", "DDB_G0267748", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54DK3", "DDB_G0292152", "Q54RM2", "DDB_G0283073", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933" ] }, "reaction_10670368": { "compartment": "compartment_7660", "id": "reaction_10670368", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10669557" ], "products": [ "species_10669559" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q54Y85", "DDB_G0278367", "Q7KWN0", "DDB_G0272740", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10670392": { "compartment": "compartment_7660", "id": "reaction_10670392", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669499" ], "products": [ "species_113582", "species_10670371" ], "modifiers": [ [ "species_10670389", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726144": { "compartment": "compartment_7660", "id": "reaction_10726144", "reactome": "R-DDI-9749215", "name": "MCM8 binds CDC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669506", "species_10669499" ], "products": [ "species_10669508" ], "modifiers": [], "additional_components": [ "DDB_G0283009", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10669949": { "compartment": "compartment_7660", "id": "reaction_10669949", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669659", "species_10669917" ], "products": [ "species_10669920" ], "modifiers": [ [ "species_10669946", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0283073", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629" ] }, "reaction_10669510": { "compartment": "compartment_7660", "id": "reaction_10669510", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC(1-6) at replication origins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669499", "species_10669492" ], "products": [ "species_10669501" ], "modifiers": [ [ "species_10669508", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54C22", "DDB_G0293214", "Q55BR6", "DDB_G0271078", "Q552L8", "DDB_G0275983", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q552L8", "DDB_G0275983", "Q54RN8", "DDB_G0283009" ] }, "reaction_10670515": { "compartment": "compartment_70101", "id": "reaction_10670515", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10670394", "species_113592" ], "products": [ "species_10670400" ], "modifiers": [ [ "species_10670512", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275983", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q552L8", "DDB_G0275983", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54FR5", "DDB_G0290629", "Q54C30", "DDB_G0293230", "Q1ZXE6", "DDB_G0286233", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54KM3", "DDB_G0287259", "Q54D58", "DDB_G0292470", "Q551S9", "DDB_G0276377", "Q54NC6", "DDB_G0285349", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0290629", "Q94490", "DDB_G0284865", "Q54NI1", "DDB_G0285223", "Q54L48", "DDB_G0286909", "Q54I43", "DDB_G0289021", "Q54IK3", "DDB_G0290547", "Q54J83", "DDB_G0288223", "Q54VV5", "DDB_G0280113" ] }, "reaction_10670359": { "compartment": "compartment_70101", "id": "reaction_10670359", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669951" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10726205": { "compartment": "compartment_7660", "id": "reaction_10726205", "reactome": "R-DDI-9757257", "name": "MCM4, MCM6 and MCM7 form a heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669603", "species_10669613", "species_10669608" ], "products": [ "species_10669615" ], "modifiers": [], "additional_components": [ "DDB_G0275623", "DDB_G0282933", "DDB_G0272760", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669953": { "compartment": "compartment_7660", "id": "reaction_10669953", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669920" ], "products": [ "species_10669951" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10670364": { "compartment": "compartment_7660", "id": "reaction_10670364", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30185", "species_30187", "species_10669563", "species_29604", "species_29892" ], "products": [ "species_10670361" ], "modifiers": [ [ "species_10669535", "catalyst" ] ], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10726146": { "compartment": "compartment_7660", "id": "reaction_10726146", "reactome": "R-DDI-9749253", "name": "Formation of MCM2-7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10669617", "species_10669629" ], "products": [ "species_10669631" ], "modifiers": [], "additional_components": [ "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54CP4", "DDB_G0292958", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54RU0", "DDB_G0282933" ] }, "reaction_10669687": { "compartment": "compartment_7660", "id": "reaction_10669687", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10669653" ], "products": [ "species_113582", "species_10669659", "species_10669663" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54C22", "DDB_G0293214", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q86AD6", "DDB_G0271562", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q54P62", "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q54RU0", "DDB_G0282933", "Q54RN8", "DDB_G0283009", "DDB_G0283073", "Q54CP4", "DDB_G0292958", "Q55CU7", "DDB_G0269894", "Q54VI9", "DDB_G0280309", "Q54LI2", "DDB_G0286623", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q55BR6", "DDB_G0271078", "Q86B14", "DDB_G0272760", "Q86IF1", "DDB_G0275623", "Q54P62", "DDB_G0284771", "Q86AD6", "DDB_G0271562", "Q54RN8", "DDB_G0283009", "Q54RU0", "DDB_G0282933", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10670396": { "compartment": "compartment_7660", "id": "reaction_10670396", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670371" ], "products": [ "species_10670394" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10682559": { "compartment": "compartment_13231", "id": "reaction_10682559", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682537" ], "products": [ "species_10682557" ], "modifiers": [], "additional_components": [ "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184", "Q54QI2", "DDB_G0293184", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0293184", "Q54C77", "DDB_G0293184" ] }, "reaction_10682346": { "compartment": "compartment_7660", "id": "reaction_10682346", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682340", "species_29428" ], "products": [ "species_10682344" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10682565": { "compartment": "compartment_70101", "id": "reaction_10682565", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682561" ], "products": [ "species_10682563" ], "modifiers": [ [ "species_10682513", "catalyst" ] ], "additional_components": [ "DDB_G0277849", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10697851": { "compartment": "compartment_70101", "id": "reaction_10697851", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697839", "species_29356" ], "products": [ "species_10697849", "species_29372" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066" ] }, "reaction_10697883": { "compartment": "compartment_70101", "id": "reaction_10697883", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697849" ], "products": [ "species_29370", "species_10697839" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54WY1", "DDB_G0279329", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10702356": { "compartment": "compartment_876", "id": "reaction_10702356", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10702353", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10726153": { "compartment": "compartment_5460", "id": "reaction_10726153", "reactome": "R-DDI-9749971", "name": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_9750012", "species_113593" ], "products": [ "species_159448", "species_9749985", "species_159450" ], "modifiers": [ [ "species_10677095", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10726183": { "compartment": "compartment_70101", "id": "reaction_10726183", "reactome": "R-DDI-9753280", "name": "GSTs transfer GSH to NAPQI to form APAP-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9753466" ], "products": [ "species_9753685", "species_29356" ], "modifiers": [ [ "species_10726180", "catalyst" ] ], "additional_components": [ "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54JU2", "DDB_G0293122", "Q556P3", "DDB_G0273153", "Q556G3", "DDB_G0272632", "Q54C73", "DDB_G0293122" ] }, "reaction_10726191": { "compartment": "compartment_70101", "id": "reaction_10726191", "reactome": "R-DDI-9753284", "name": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_9753629", "species_29356" ], "products": [ "species_29370", "species_9753624", "species_29372" ], "modifiers": [ [ "species_10726188", "catalyst" ] ], "additional_components": [ "CHEBI:133438", "species_9753653", "CHEBI:133066", "CHEBI:133435", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726193": { "compartment": "compartment_12045", "id": "reaction_10726193", "reactome": "R-DDI-9753285", "name": "CYP2E1 monooxygenates APAP to NAPQI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_29368", "species_9677362" ], "products": [ "species_29366", "species_9753466", "species_29356" ], "modifiers": [ [ "species_10675234", "catalyst" ], [ "species_9753674", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726151": { "compartment": "compartment_17957", "id": "reaction_10726151", "reactome": "R-DDI-9749792", "name": "CES1,CES2 hydrolyze ASA- to ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749795" ], "products": [ "species_9749588", "species_9749790", "species_156540" ], "modifiers": [ [ "species_10709873", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726156": { "compartment": "compartment_17957", "id": "reaction_10726156", "reactome": "R-DDI-9749977", "name": "UGT1A6 glucuronates ST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_174384" ], "products": [ "species_158602", "species_9749997" ], "modifiers": [ [ "species_10677028", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726178": { "compartment": "compartment_70101", "id": "reaction_10726178", "reactome": "R-DDI-9753278", "name": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10726175", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "Q86HQ2", "DDB_G0274117", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q8T685", "DDB_G0274115", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q54JR2", "DDB_G0287691", "Q8T686", "DDB_G0289655" ] }, "reaction_10726168": { "compartment": "compartment_70101", "id": "reaction_10726168", "reactome": "R-DDI-9750656", "name": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9750692", "species_113592", "species_29356" ], "products": [ "species_29370", "species_9750678", "species_29372" ], "modifiers": [ [ "species_10726165", "catalyst" ] ], "additional_components": [ "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "CHEBI:9008", "species_9750012", "CHEBI:88742", "CHEBI:176976", "species_9750011", "species_9749997", "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10726158": { "compartment": "compartment_17957", "id": "reaction_10726158", "reactome": "R-DDI-9749986", "name": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_9750011", "species_113519" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726160": { "compartment": "compartment_17957", "id": "reaction_10726160", "reactome": "R-DDI-9750016", "name": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9749790", "species_113534" ], "products": [ "species_113519", "species_9750014" ], "modifiers": [ [ "species_10724036", "catalyst" ] ], "additional_components": [ "Q54SV9", "DDB_G0282283", "Q1ZXL2", "DDB_G0275197", "Q556M5", "DDB_G0273045", "Q54NY3", "DDB_G0284923", "Q54DT2", "DDB_G0292168", "Q1ZXG3", "DDB_G0282769", "Q556M4", "DDB_G0272604", "Q1ZXF3", "DDB_G0284647", "Q55AJ4", "DDB_G0271778", "Q86A22", "DDB_G0272704", "Q1ZXA4", "DDB_G0292790", "Q54ZM4", "DDB_G0277545", "Q54LT7", "DDB_G0286419", "Q1ZXL7", "DDB_G0273047", "Q54CS3", "DDB_G0292792", "Q1ZXF5", "DDB_G0284535", "Q54LA8", "DDB_G0286743", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q54SK0", "DDB_G0282419", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54EM5", "DDB_G0291448" ] }, "reaction_10726149": { "compartment": "compartment_17957", "id": "reaction_10726149", "reactome": "R-DDI-9749647", "name": "CES2 hydrolyzes ASA-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9749582" ], "products": [ "species_9749588", "species_156540", "species_9749593" ], "modifiers": [ [ "species_10709871", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344" ] }, "reaction_10726197": { "compartment": "compartment_70101", "id": "reaction_10726197", "reactome": "R-DDI-9753944", "name": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9753926" ], "products": [ "species_9717939", "species_111707" ], "modifiers": [ [ "species_10702280", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10696232": { "compartment": "compartment_70101", "id": "reaction_10696232", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_73473", "species_2162081" ], "modifiers": [ [ "species_10671976", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10677043": { "compartment": "compartment_70101", "id": "reaction_10677043", "reactome": "R-DDI-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_9677362" ], "products": [ "species_110096", "species_158604" ], "modifiers": [ [ "species_10677040", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FX8", "DDB_G0268544", "Q55FB2", "DDB_G0268544" ] }, "reaction_10726186": { "compartment": "compartment_70101", "id": "reaction_10726186", "reactome": "R-DDI-9753283", "name": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_9753559" ], "products": [ "species_29370", "species_9753562", "species_29372" ], "modifiers": [ [ "species_10679868", "catalyst" ] ], "additional_components": [ "CHEBI:32635", "species_158604", "CHEBI:32636", "CHEBI:32635", "DDB_G0285165" ] }, "reaction_10696229": { "compartment": "compartment_70101", "id": "reaction_10696229", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10674352", "catalyst" ] ], "additional_components": [ "Q54JY6", "DDB_G0287735", "species_29926", "Q54XC1", "DDB_G0279053" ] }, "reaction_10726195": { "compartment": "compartment_70101", "id": "reaction_10726195", "reactome": "R-DDI-9753632", "name": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9753680", "species_29356" ], "products": [ "species_9753653", "species_29424" ], "modifiers": [ [ "species_10690095", "catalyst" ] ], "additional_components": [ "Q54X02", "DDB_G0279291", "species_29418" ] }, "reaction_10673891": { "compartment": "compartment_7660", "id": "reaction_10673891", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673887", "species_10673882" ], "products": [ "species_10673889" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q54HB0", "DDB_G0289587", "Q86H36", "DDB_G0275759", "Q55AB6", "DDB_G0272036", "Q54BM1", "DDB_G0293560", "Q54FA8", "DDB_G0291037", "Q54SN4", "DDB_G0282339" ] }, "reaction_10674680": { "compartment": "compartment_350", "id": "reaction_10674680", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_74985" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10673976", "catalyst" ], [ "species_10674678", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54RQ4", "DDB_G0282987", "Q54WG6", "DDB_G0279667", "Q54LP8", "DDB_G0286509", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10673978": { "compartment": "compartment_7660", "id": "reaction_10673978", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673972" ], "products": [ "species_10673887", "species_10673976" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q54HB0", "DDB_G0289587", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339", "DDB_G0289587", "Q55G81", "DDB_G0267414", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54FE8", "DDB_G0290909", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q86H36", "DDB_G0275759", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54YF5", "DDB_G0278263", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54BM1", "DDB_G0293560", "Q55FP1", "DDB_G0268014", "Q54SN4", "DDB_G0282339" ] }, "reaction_10683664": { "compartment": "compartment_70101", "id": "reaction_10683664", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683624", "species_10683658" ], "products": [ "species_10683660", "species_10683662" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705971": { "compartment": "compartment_70101", "id": "reaction_10705971", "reactome": "R-DDI-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705850" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10705961": { "compartment": "compartment_70101", "id": "reaction_10705961", "reactome": "R-DDI-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705931" ], "products": [ "species_10705959" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10709756": { "compartment": "compartment_7660", "id": "reaction_10709756", "reactome": "R-DDI-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705955", "species_10670747" ], "products": [ "species_10709754" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10705903": { "compartment": "compartment_70101", "id": "reaction_10705903", "reactome": "R-DDI-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705864", "species_113592" ], "products": [ "species_29370", "species_10705900" ], "modifiers": [ [ "species_10702686", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10705968": { "compartment": "compartment_7660", "id": "reaction_10705968", "reactome": "R-DDI-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705959" ], "products": [ "species_10705931" ], "modifiers": [ [ "species_10705966", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "DDB_G0291306" ] }, "reaction_10685265": { "compartment": "compartment_876", "id": "reaction_10685265", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685262", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685272": { "compartment": "compartment_876", "id": "reaction_10685272", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685269", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685247": { "compartment": "compartment_876", "id": "reaction_10685247", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10685249": { "compartment": "compartment_876", "id": "reaction_10685249", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10685244", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10674798": { "compartment": "compartment_7660", "id": "reaction_10674798", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670822", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0285963" ] }, "reaction_10724052": { "compartment": "compartment_70101", "id": "reaction_10724052", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674686" ], "products": [ "species_10674690" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10705346": { "compartment": "compartment_7660", "id": "reaction_10705346", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705342" ], "products": [ "species_10705344" ], "modifiers": [], "additional_components": [ "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10705349": { "compartment": "compartment_7660", "id": "reaction_10705349", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705344" ], "products": [ "species_113582", "species_10670822" ], "modifiers": [ [ "species_10705344", "catalyst" ] ], "additional_components": [ "Q54MH0", "DDB_G0285963", "DDB_G0285963", "Q54MH0", "DDB_G0285963" ] }, "reaction_10674688": { "compartment": "compartment_7660", "id": "reaction_10674688", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10674683" ], "products": [ "species_113582", "species_10674686" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10702591": { "compartment": "compartment_876", "id": "reaction_10702591", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10702588" ], "products": [ "species_29370", "species_10702566" ], "modifiers": [ [ "species_10683660", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450" ] }, "reaction_10698157": { "compartment": "compartment_70101", "id": "reaction_10698157", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10676232", "species_10695461" ], "products": [ "species_10698131" ], "modifiers": [], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034" ] }, "reaction_10698155": { "compartment": "compartment_70101", "id": "reaction_10698155", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698135" ], "products": [ "species_10698153" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10702593": { "compartment": "compartment_876", "id": "reaction_10702593", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10678454" ], "products": [ "species_10702588" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996" ] }, "reaction_10702481": { "compartment": "compartment_70101", "id": "reaction_10702481", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194", "species_10702478" ], "products": [ "species_10683047", "species_76183" ], "modifiers": [ [ "species_10701954", "catalyst" ] ], "additional_components": [ "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "species_29420", "P32255", "DDB_G0287689", "P32256", "DDB_G0269196", "species_29438", "Q54TA6", "DDB_G0281889", "DDB_G0279267" ] }, "reaction_10706065": { "compartment": "compartment_17927", "id": "reaction_10706065", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10706055" ], "products": [ "species_5688340", "species_5688281", "species_10676517" ], "modifiers": [ [ "species_10706062", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10722767": { "compartment": "compartment_876", "id": "reaction_10722767", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722762" ], "products": [ "species_10722748", "species_29372" ], "modifiers": [ [ "species_10722762", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10676269": { "compartment": "compartment_70101", "id": "reaction_10676269", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10678297": { "compartment": "compartment_876", "id": "reaction_10678297", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_30389", "species_111294" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10678304": { "compartment": "compartment_876", "id": "reaction_10678304", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678285" ], "products": [ "species_29372", "species_10678299" ], "modifiers": [ [ "species_10678285", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10722750": { "compartment": "compartment_876", "id": "reaction_10722750", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722748" ], "products": [ "species_10678290", "species_10722746" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10682978": { "compartment": "compartment_947587", "id": "reaction_10682978", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10682971" ], "products": [ "species_29420", "species_10682975" ], "modifiers": [ [ "species_10682971", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "species_29438", "P36408", "DDB_G0277143", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "species_916850", "P34044", "DDB_G0283151", "Q54K09", "DDB_G0287905", "Q54F54", "DDB_G0291095", "Q54ET0", "DDB_G0291356", "P36408", "DDB_G0277143", "species_111349" ] }, "reaction_10678288": { "compartment": "compartment_876", "id": "reaction_10678288", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10678254" ], "products": [ "species_10678285" ], "modifiers": [ [ "species_10676221", "catalyst" ] ], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926" ] }, "reaction_10678301": { "compartment": "compartment_876", "id": "reaction_10678301", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678299" ], "products": [ "species_10676221", "species_10678276" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10677642": { "compartment": "compartment_947587", "id": "reaction_10677642", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676141", "species_29420" ], "products": [ "species_29438", "species_10676271" ], "modifiers": [ [ "species_10676139", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151" ] }, "reaction_10722764": { "compartment": "compartment_876", "id": "reaction_10722764", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678270", "species_10722746" ], "products": [ "species_10722762" ], "modifiers": [], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10724973": { "compartment": "compartment_70101", "id": "reaction_10724973", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10679149", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10697954": { "compartment": "compartment_876", "id": "reaction_10697954", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10697951", "catalyst" ] ], "additional_components": [ "Q86I16", "DDB_G0275169", "Q54SN1", "DDB_G0282291", "Q55CU6", "DDB_G0275169" ] }, "reaction_10676383": { "compartment": "compartment_7660", "id": "reaction_10676383", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10676338", "species_10672161" ], "products": [ "species_10673970", "species_10676376" ], "modifiers": [ [ "species_10676338", "catalyst" ] ], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "DDB_G0271690", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0271690" ] }, "reaction_10676458": { "compartment": "compartment_7660", "id": "reaction_10676458", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676454" ], "products": [ "species_10676456" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676444": { "compartment": "compartment_7660", "id": "reaction_10676444", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676440" ], "products": [ "species_10673970", "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K42", "DDB_G0287661", "Q54I13", "DDB_G0289079", "Q556Z2", "DDB_G0273207", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676466": { "compartment": "compartment_7660", "id": "reaction_10676466", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676376", "species_10676333" ], "products": [ "species_10676378" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676472": { "compartment": "compartment_7660", "id": "reaction_10676472", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9757634", "species_10676442" ], "products": [ "species_9757634", "species_10676454" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10697522": { "compartment": "compartment_70101", "id": "reaction_10697522", "reactome": "R-DDI-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473617", "species_10674488" ], "products": [ "species_10697520" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_5623649", "Q54YX3", "DDB_G0278031" ] }, "reaction_10697518": { "compartment": "compartment_70101", "id": "reaction_10697518", "reactome": "R-DDI-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674490", "species_200993" ], "products": [ "species_76194", "species_10697513" ], "modifiers": [ [ "species_10697515", "catalyst" ] ], "additional_components": [ "species_30927", "Q54YX3", "DDB_G0278031", "CHEBI:16254", "Q54YX3", "DDB_G0278031", "DDB_G0290279" ] }, "reaction_10676906": { "compartment": "compartment_7660", "id": "reaction_10676906", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676900" ], "products": [ "species_29370", "species_10676904" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10697578": { "compartment": "compartment_1598585", "id": "reaction_10697578", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10697563" ], "products": [ "species_29370", "species_10697575" ], "modifiers": [ [ "species_10678756", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "DDB_G0274503" ] }, "reaction_10675117": { "compartment": "compartment_7660", "id": "reaction_10675117", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675051" ], "products": [ "species_10675115" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10725407": { "compartment": "compartment_876", "id": "reaction_10725407", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10704197" ], "products": [ "species_10704199" ], "modifiers": [], "additional_components": [ "pubchem.compound:16719221", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10704211": { "compartment": "compartment_876", "id": "reaction_10704211", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704197" ], "products": [ "species_29370", "species_10704188" ], "modifiers": [ [ "species_10704197", "catalyst" ], [ "species_10704209", "inhibitor" ], [ "species_10704199", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385" ] }, "reaction_10725409": { "compartment": "compartment_876", "id": "reaction_10725409", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657570" ], "products": [ "species_10704201" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=8056", "LigandDisplayForward?ligandId=9974", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385" ] }, "reaction_10725415": { "compartment": "compartment_876", "id": "reaction_10725415", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10704192" ], "products": [ "species_10725413" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "LigandDisplayForward?ligandId=9229", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9229", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9210", "LigandDisplayForward?ligandId=9375", "P18160", "DDB_G0283385" ] }, "reaction_10725411": { "compartment": "compartment_876", "id": "reaction_10725411", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704188", "species_9657574" ], "products": [ "species_10704195" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "LigandDisplayForward?ligandId=7626", "LigandDisplayForward?ligandId=7872", "LigandDisplayForward?ligandId=7935", "LigandDisplayForward?ligandId=5665", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=5676", "LigandDisplayForward?ligandId=7921", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704203": { "compartment": "compartment_876", "id": "reaction_10704203", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704188" ], "products": [ "species_29370", "species_10704192" ], "modifiers": [ [ "species_10704188", "catalyst" ], [ "species_10704199", "inhibitor" ], [ "species_10704201", "inhibitor" ], [ "species_10704195", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=9909", "LigandDisplayForward?ligandId=6495", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "pubchem.compound:16719221", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=9974", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=8056", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "LigandDisplayForward?ligandId=7935", "Q54HS0", "DDB_G0289277", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "LigandDisplayForward?ligandId=5676", "P54632", "DDB_G0269138", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q54K32", "DDB_G0287585", "Q54VD5", "DDB_G0280437", "species_29438", "LigandDisplayForward?ligandId=5665", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=7942", "LigandDisplayForward?ligandId=7921", "LigandDisplayForward?ligandId=7626", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=7872", "P18160", "DDB_G0283385" ] }, "reaction_10704251": { "compartment": "compartment_74700", "id": "reaction_10704251", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10704247" ], "products": [ "species_29370", "species_10704249" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54H44", "DDB_G0289711", "Q54TM7", "DDB_G0281557", "Q54F59", "DDB_G0291091", "Q54HS0", "DDB_G0289277", "Q54XX5", "DDB_G0278535", "Q86J23", "DDB_G0274833" ] }, "reaction_10700856": { "compartment": "compartment_7660", "id": "reaction_10700856", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_113671", "species_113685" ], "products": [ "species_10698653", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10699170": { "compartment": "compartment_7660", "id": "reaction_10699170", "reactome": "R-DDI-3318486", "name": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_113560" ], "products": [ "species_2485002", "species_10699149" ], "modifiers": [ [ "species_10699167", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10701877": { "compartment": "compartment_7660", "id": "reaction_10701877", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623", "species_77087" ], "products": [ "species_10696628", "species_77502" ], "modifiers": [ [ "species_10701874", "catalyst" ], [ "species_10701399", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q54MH6", "DDB_G0285847", "Q54IV4", "DDB_G0288495", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "O15819", "DDB_G0267402" ] }, "reaction_10703003": { "compartment": "compartment_7660", "id": "reaction_10703003", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702990", "species_77087" ], "products": [ "species_10702995", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10701096": { "compartment": "compartment_7660", "id": "reaction_10701096", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698653", "species_77502" ], "modifiers": [ [ "species_10701093", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q86A13", "DDB_G0287857", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132", "Q54J80", "DDB_G0288227" ] }, "reaction_10703010": { "compartment": "compartment_7660", "id": "reaction_10703010", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702995", "species_77087" ], "products": [ "species_10703008", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700971": { "compartment": "compartment_7660", "id": "reaction_10700971", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700828", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10701276": { "compartment": "compartment_7660", "id": "reaction_10701276", "reactome": "R-DDI-5205799", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10698791", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ], [ "species_10701274", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "Q54NM0", "DDB_G0285205", "Q54WV6", "DDB_G0279373", "Q556Z0", "DDB_G0273203", "Q55C32", "DDB_G0285205", "Q54UQ7", "DDB_G0280887", "Q54KI3", "DDB_G0287327", "Q550R6", "DDB_G0277033" ] }, "reaction_10703386": { "compartment": "compartment_7660", "id": "reaction_10703386", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701268", "species_77087" ], "products": [ "species_10703384", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703018": { "compartment": "compartment_7660", "id": "reaction_10703018", "reactome": "R-DDI-5649802", "name": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10700861" ], "products": [ "species_77502", "species_10703016" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703368": { "compartment": "compartment_7660", "id": "reaction_10703368", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10696628", "species_113685" ], "products": [ "species_159942", "species_10696623", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700853", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55ER4", "DDB_G0268778" ] }, "reaction_10702952": { "compartment": "compartment_7660", "id": "reaction_10702952", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700828", "species_77087" ], "products": [ "species_10702945", "species_77502" ], "modifiers": [ [ "species_10700968", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q55FX4", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q54R14", "DDB_G0294629", "C7G064", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "B0G196", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q55FF7", "DDB_G0268132" ] }, "reaction_10698670": { "compartment": "compartment_7660", "id": "reaction_10698670", "reactome": "R-DDI-3214912", "name": "KDM1A, KDM1B demethylate MeK5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653" ], "products": [ "species_10698655", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10699592": { "compartment": "compartment_7660", "id": "reaction_10699592", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_113560" ], "products": [ "species_2485002", "species_10699570" ], "modifiers": [ [ "species_10699589", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q86J12", "DDB_G0274269", "Q54QW6", "DDB_G0283565" ] }, "reaction_10725840": { "compartment": "compartment_7660", "id": "reaction_10725840", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699922", "species_9679795" ], "products": [ "species_10699925" ], "modifiers": [], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "LigandDisplayForward?ligandId=7489", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10701685": { "compartment": "compartment_7660", "id": "reaction_10701685", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701663", "species_10701077" ], "products": [ "species_10701683" ], "modifiers": [], "additional_components": [ "O15819", "DDB_G0267402", "DDB_G0287273", "Q54KL5", "DDB_G0287273", "O15819", "DDB_G0267402" ] }, "reaction_10701512": { "compartment": "compartment_7660", "id": "reaction_10701512", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10701458" ], "products": [ "species_10701510", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "DDB_G0291556" ] }, "reaction_10701271": { "compartment": "compartment_7660", "id": "reaction_10701271", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674568", "species_77087" ], "products": [ "species_10701268", "species_77502" ], "modifiers": [ [ "species_10698675", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0291556" ] }, "reaction_10703381": { "compartment": "compartment_7660", "id": "reaction_10703381", "reactome": "R-DDI-5661123", "name": "KDM1A, KDM1B demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696623" ], "products": [ "species_10698653", "species_29478" ], "modifiers": [ [ "species_10698667", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q556K4", "DDB_G0272584", "Q556K3", "DDB_G0272582" ] }, "reaction_10702931": { "compartment": "compartment_7660", "id": "reaction_10702931", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698653", "species_77087" ], "products": [ "species_10696623", "species_77502" ], "modifiers": [ [ "species_10702928", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55AQ4", "DDB_G0271754", "Q55FP6", "DDB_G0287857", "Q54MH6", "DDB_G0285847", "Q54JW6", "DDB_G0287857", "Q54IV4", "DDB_G0288495", "Q86A13", "DDB_G0287857", "Q54KL5", "DDB_G0287273", "Q54HS3", "DDB_G0289257", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703014": { "compartment": "compartment_7660", "id": "reaction_10703014", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10702990", "species_77502" ], "modifiers": [ [ "species_10703000", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0271626" ] }, "reaction_10700840": { "compartment": "compartment_7660", "id": "reaction_10700840", "reactome": "R-DDI-4724279", "name": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_113671", "species_113685" ], "products": [ "species_10700832", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10701689": { "compartment": "compartment_7660", "id": "reaction_10701689", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_10699587" ], "products": [ "species_10701687" ], "modifiers": [ [ "species_10701663", "inhibitor" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "O15819", "DDB_G0267402", "Q54QW6", "DDB_G0283565", "O15819", "DDB_G0267402" ] }, "reaction_10703379": { "compartment": "compartment_7660", "id": "reaction_10703379", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10703016", "species_113685" ], "products": [ "species_159942", "species_159939", "species_29478", "species_10700861" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10700873": { "compartment": "compartment_7660", "id": "reaction_10700873", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10700861", "species_113685" ], "products": [ "species_10700866", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700868", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0269194" ] }, "reaction_10699111": { "compartment": "compartment_7660", "id": "reaction_10699111", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696626", "species_113560" ], "products": [ "species_2485002", "species_10699070" ], "modifiers": [ [ "species_10699108", "catalyst" ] ], "additional_components": [ "DDB_G0267402", "DDB_G0267402", "Q869X5", "DDB_G0275017", "B0G130", "DDB_G0279699", "Q54PN9", "DDB_G0284411", "Q54NG3", "DDB_G0285275" ] }, "reaction_10698695": { "compartment": "compartment_7660", "id": "reaction_10698695", "reactome": "R-DDI-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698686" ], "products": [ "species_10698692" ], "modifiers": [ [ "species_10698686", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10700892": { "compartment": "compartment_7660", "id": "reaction_10700892", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700830", "species_77087" ], "products": [ "species_77502", "species_10700884" ], "modifiers": [ [ "species_10700889", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0289257" ] }, "reaction_10703012": { "compartment": "compartment_7660", "id": "reaction_10703012", "reactome": "R-DDI-5649800", "name": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700866", "species_77087" ], "products": [ "species_77502", "species_10700861" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10703377": { "compartment": "compartment_7660", "id": "reaction_10703377", "reactome": "R-DDI-5661120", "name": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_113685", "species_10700884" ], "products": [ "species_10700830", "species_159942", "species_159939", "species_29478" ], "modifiers": [ [ "species_10700837", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "DDB_G0287513" ] }, "reaction_10703375": { "compartment": "compartment_7660", "id": "reaction_10703375", "reactome": "R-DDI-5661117", "name": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698791", "species_77087" ], "products": [ "species_10703373", "species_77502" ], "modifiers": [ [ "species_10698692", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54KI3", "DDB_G0287327" ] }, "reaction_10699927": { "compartment": "compartment_7660", "id": "reaction_10699927", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699922", "catalyst" ], [ "species_10699925", "inhibitor" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845", "Q55FN5", "DDB_G0268024", "LigandDisplayForward?ligandId=7489", "Q54SD4", "DDB_G0282529", "Q54LI3", "DDB_G0286805", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0286805", "LigandDisplayForward?ligandId=7009", "LigandDisplayForward?ligandId=7006", "LigandDisplayForward?ligandId=6852", "LigandDisplayForward?ligandId=7496", "Q54QW6", "DDB_G0283565", "Q54QG3", "DDB_G0283845" ] }, "reaction_10702957": { "compartment": "compartment_7660", "id": "reaction_10702957", "reactome": "R-DDI-5638333", "name": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698655", "species_77087" ], "products": [ "species_10700866", "species_77502" ], "modifiers": [ [ "species_10702954", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "O15819", "DDB_G0267402", "Q55FF7", "DDB_G0268132" ] }, "reaction_10699946": { "compartment": "compartment_7660", "id": "reaction_10699946", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10699878" ], "products": [ "species_10699884", "species_5566518" ], "modifiers": [ [ "species_10699943", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10682182": { "compartment": "compartment_984", "id": "reaction_10682182", "reactome": "R-DDI-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194276", "species_171149" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10682179", "catalyst" ] ], "additional_components": [ "DDB_G0279019" ] }, "reaction_10682338": { "compartment": "compartment_876", "id": "reaction_10682338", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_216762", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171095", "species_29372" ], "modifiers": [ [ "species_10682335", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10701034": { "compartment": "compartment_7660", "id": "reaction_10701034", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699495", "species_29358" ], "products": [ "species_113582", "species_10701011" ], "modifiers": [ [ "species_10701031", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569" ] }, "reaction_10701013": { "compartment": "compartment_7660", "id": "reaction_10701013", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700995" ], "products": [ "species_10701001" ], "modifiers": [ [ "species_10701006", "catalyst" ], [ "species_10701011", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10684049": { "compartment": "compartment_70101", "id": "reaction_10684049", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684045", "species_10682591" ], "products": [ "species_10684047" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "species_29438", "Q54XX5", "DDB_G0278535", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340" ] }, "reaction_10687177": { "compartment": "compartment_70101", "id": "reaction_10687177", "reactome": "R-DDI-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10683990" ], "products": [ "species_10683995" ], "modifiers": [ [ "species_10687175", "inhibitor" ] ], "additional_components": [ "DDB_G0269138", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10684035": { "compartment": "compartment_70101", "id": "reaction_10684035", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10684031" ], "products": [ "species_10684033" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "species_30389" ] }, "reaction_10683997": { "compartment": "compartment_70101", "id": "reaction_10683997", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682591" ], "products": [ "species_10682593", "species_111294" ], "modifiers": [ [ "species_10683992", "catalyst" ], [ "species_10683995", "inhibitor" ] ], "additional_components": [ "species_29438", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "species_29420", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734", "Q54SS8", "DDB_G0282247", "Q869V0", "DDB_G0291510", "P54632", "DDB_G0269138", "Q55AN8", "DDB_G0291510", "Q54EH3", "DDB_G0291510", "Q54RS9", "DDB_G0291510", "Q54RT1", "DDB_G0291510", "Q54Q75", "DDB_G0291510", "Q75J96", "DDB_G0271734" ] }, "reaction_10675956": { "compartment": "compartment_7660", "id": "reaction_10675956", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675951" ], "products": [ "species_10675953", "species_110242" ], "modifiers": [ [ "species_10675951", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10675977": { "compartment": "compartment_7660", "id": "reaction_10675977", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675972" ], "products": [ "species_10675974", "species_5635947" ], "modifiers": [ [ "species_10675972", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10711308": { "compartment": "compartment_984", "id": "reaction_10711308", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171126", "species_109276" ], "products": [ "species_6789319", "species_174675" ], "modifiers": [ [ "species_10711305", "catalyst" ] ], "additional_components": [ "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966", "Q55EU1", "DDB_G0268966" ] }, "reaction_10685610": { "compartment": "compartment_70101", "id": "reaction_10685610", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683631", "species_113592", "species_10676526" ], "products": [ "species_29370", "species_10683629", "species_10685607" ], "modifiers": [ [ "species_10683629", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55GV3", "DDB_G0267450", "DDB_G0267450" ] }, "reaction_10687031": { "compartment": "compartment_876", "id": "reaction_10687031", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687023", "species_10687027" ], "products": [ "species_10687029" ], "modifiers": [], "additional_components": [ "DDB_G0287833", "species_1236719", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125", "species_1236719", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "CHEBI:53014", "CHEBI:60125" ] }, "reaction_10716012": { "compartment": "compartment_7660", "id": "reaction_10716012", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10716000" ], "products": [ "species_113582", "species_10716009" ], "modifiers": [ [ "species_10716000", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54FD6", "DDB_G0290929", "Q54KJ8", "DDB_G0287307", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54LJ0", "DDB_G0286617", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54B89", "DDB_G0293830", "Q54J75", "DDB_G0288257", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55AB6", "DDB_G0272036", "Q556Z2", "DDB_G0273207", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q557M8", "DDB_G0273525", "Q54IW7", "DDB_G0288471", "Q54KT7", "DDB_G0287131" ] }, "reaction_10676885": { "compartment": "compartment_7660", "id": "reaction_10676885", "reactome": "R-DDI-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676872" ], "products": [ "species_113582", "species_10676876" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10676923": { "compartment": "compartment_7660", "id": "reaction_10676923", "reactome": "R-DDI-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10676918" ], "products": [ "species_113582", "species_10676921" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0268258", "DDB_G0268258", "DDB_G0274503" ] }, "reaction_10726046": { "compartment": "compartment_70101", "id": "reaction_10726046", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721285", "species_9714134" ], "products": [ "species_10726044" ], "modifiers": [], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "LigandDisplayForward?ligandId=6569", "LigandDisplayForward?ligandId=7045", "LigandDisplayForward?ligandId=5786", "Q54NZ5", "DDB_G0284903", "LigandDisplayForward?ligandId=6569", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10682925": { "compartment": "compartment_70101", "id": "reaction_10682925", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_9677992" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10682923": { "compartment": "compartment_70101", "id": "reaction_10682923", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362", "species_29368", "species_29356" ], "products": [ "species_29408", "species_9677997", "species_29382" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10683515": { "compartment": "compartment_17947", "id": "reaction_10683515", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683513", "species_10683495" ], "products": [ "species_10683511", "species_10683487", "species_10683495" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213" ] }, "reaction_10691278": { "compartment": "compartment_70101", "id": "reaction_10691278", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10691275", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103" ] }, "reaction_10704829": { "compartment": "compartment_984", "id": "reaction_10704829", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_429802", "species_29356" ], "products": [ "species_29370", "species_382539", "species_29372" ], "modifiers": [ [ "species_10704826", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10691271": { "compartment": "compartment_70101", "id": "reaction_10691271", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_1454930" ], "products": [ "species_29370", "species_1454919", "species_29372" ], "modifiers": [ [ "species_10691268", "catalyst" ] ], "additional_components": [ "Q54NL1", "DDB_G0285165", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691" ] }, "reaction_10716905": { "compartment": "compartment_70101", "id": "reaction_10716905", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_113592", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10716902", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10705130": { "compartment": "compartment_70101", "id": "reaction_10705130", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5682283" ], "products": [ "species_29370", "species_29372", "species_5229279" ], "modifiers": [ [ "species_10705127", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10682286": { "compartment": "compartment_876", "id": "reaction_10682286", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265784", "species_113592", "species_29356" ], "products": [ "species_29370", "species_265781", "species_29372" ], "modifiers": [ [ "species_10682283", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q55DW4", "DDB_G0269214" ] }, "reaction_10691341": { "compartment": "compartment_876", "id": "reaction_10691341", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131652", "species_113592", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1467459" ], "modifiers": [ [ "species_10691338", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54BU4", "DDB_G0293416", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T9W4", "DDB_G0291714", "Q8T9W1", "DDB_G0286123", "Q54RU1", "DDB_G0282931", "Q8T6J5", "DDB_G0267438", "Q54W24", "DDB_G0279915", "Q54R52", "DDB_G0283387", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438" ] }, "reaction_10683474": { "compartment": "compartment_70616", "id": "reaction_10683474", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_189444", "species_113593" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10683471", "catalyst" ] ], "additional_components": [ "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q54RU1", "DDB_G0282931", "Q23868", "DDB_G0286121", "Q54W24", "DDB_G0279915", "Q54BU4", "DDB_G0293416", "Q9GTN7", "DDB_G0293002", "Q54BT3", "DDB_G0293438", "Q8T9W2", "DDB_G0292554", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10701720": { "compartment": "compartment_70101", "id": "reaction_10701720", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_10701716" ], "products": [ "species_10701718" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436", "Q869N9", "DDB_G0271862" ] }, "reaction_10690498": { "compartment": "compartment_876", "id": "reaction_10690498", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_113592", "species_29356" ], "products": [ "species_29370", "species_171149", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10690500": { "compartment": "compartment_876", "id": "reaction_10690500", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_171149", "species_29356" ], "products": [ "species_29370", "species_176478", "species_29372" ], "modifiers": [ [ "species_10690495", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10691362": { "compartment": "compartment_74000", "id": "reaction_10691362", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_2466098" ], "products": [ "species_29370", "species_975622", "species_29372" ], "modifiers": [ [ "species_10691359", "catalyst" ] ], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10683490": { "compartment": "compartment_17947", "id": "reaction_10683490", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_382577", "species_113592", "species_29356" ], "products": [ "species_29370", "species_382571", "species_29372" ], "modifiers": [ [ "species_10683487", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10677433": { "compartment": "compartment_70101", "id": "reaction_10677433", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677425" ], "products": [ "species_29370", "species_10677430" ], "modifiers": [ [ "species_10675814", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10722655": { "compartment": "compartment_876", "id": "reaction_10722655", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722652" ], "products": [ "species_10679174", "species_10679153" ], "modifiers": [ [ "species_10722652", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "DDB_G0274211", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10722657": { "compartment": "compartment_876", "id": "reaction_10722657", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679174", "species_10678454" ], "products": [ "species_10722652" ], "modifiers": [], "additional_components": [ "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSU4", "DDB_G0274211", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10716950": { "compartment": "compartment_876", "id": "reaction_10716950", "reactome": "R-DDI-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10695507" ], "products": [ "species_10676526", "species_29420" ], "modifiers": [ [ "species_10716947", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q55GR7", "DDB_G0267548", "Q54WH5", "DDB_G0279657", "Q54RS7", "DDB_G0282949", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54YW1", "DDB_G0278051", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54NW4", "DDB_G0284863" ] }, "reaction_10716247": { "compartment": "compartment_263163", "id": "reaction_10716247", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10716238" ], "products": [ "species_10716244", "species_29420" ], "modifiers": [ [ "species_10716238", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "species_29438", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716664": { "compartment": "compartment_263163", "id": "reaction_10716664", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716608", "species_10710119", "species_10710110" ], "products": [ "species_10716662" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716705": { "compartment": "compartment_263163", "id": "reaction_10716705", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716701", "species_10710119", "species_10710110" ], "products": [ "species_10716703" ], "modifiers": [], "additional_components": [ "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q553C3", "DDB_G0275765", "Q551H5", "DDB_G0276575", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q54R67", "DDB_G0283363", "Q54PQ5", "DDB_G0284385", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716764": { "compartment": "compartment_263163", "id": "reaction_10716764", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716751", "species_10716762" ], "products": [ "species_10716753" ], "modifiers": [], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "DDB_G0278181", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716760": { "compartment": "compartment_263163", "id": "reaction_10716760", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716753" ], "products": [ "species_10716757" ], "modifiers": [ [ "species_10716753", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "species_29420", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q54YL8", "DDB_G0278181", "Q552K3", "DDB_G0275969", "species_29438", "Q54EW9", "DDB_G0291293", "P34141", "DDB_G0291233" ] }, "reaction_10716424": { "compartment": "compartment_263163", "id": "reaction_10716424", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716420", "species_10716405" ], "products": [ "species_10716422" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716667": { "compartment": "compartment_263163", "id": "reaction_10716667", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716662", "species_113592" ], "products": [ "species_29370", "species_10716530", "species_10716540", "species_10710119", "species_10716596", "species_10710110", "species_10716532" ], "modifiers": [ [ "species_10716662", "catalyst" ] ], "additional_components": [ "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575", "DDB_G0284185", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q9U9R7", "DDB_G0269186", "Q54NP6", "DDB_G0285111", "DDB_G0290363", "Q75JI3", "DDB_G0276153", "DDB_G0276575", "Q54R67", "DDB_G0283363", "Q75JI3", "DDB_G0276153", "Q54CK6", "DDB_G0292974", "Q54PW2", "DDB_G0284185", "Q9U9R7", "DDB_G0269186", "Q54GB3", "DDB_G0290363", "Q553C3", "DDB_G0275765", "Q54NP6", "DDB_G0285111", "Q551H5", "DDB_G0276575" ] }, "reaction_10716407": { "compartment": "compartment_263163", "id": "reaction_10716407", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716399", "species_10716391" ], "products": [ "species_10716405" ], "modifiers": [], "additional_components": [ "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631", "Q55E69", "DDB_G0269368", "Q54JB7", "DDB_G0288163", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10716240": { "compartment": "compartment_263163", "id": "reaction_10716240", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716220", "species_10716232" ], "products": [ "species_10716238" ], "modifiers": [], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "species_29420", "Q55FK2", "DDB_G0268068", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477" ] }, "reaction_10716413": { "compartment": "compartment_263163", "id": "reaction_10716413", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10716411", "species_10716381" ], "products": [ "species_10716391" ], "modifiers": [], "additional_components": [ "species_29438", "Q54QU7", "DDB_G0283631", "DDB_G0269368", "Q55E69", "DDB_G0269368", "species_29438", "Q54QU7", "DDB_G0283631" ] }, "reaction_10721886": { "compartment": "compartment_70616", "id": "reaction_10721886", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10721883", "catalyst" ] ], "additional_components": [ "Q54LT0", "DDB_G0286429", "Q54JS1", "DDB_G0287825" ] }, "reaction_10685511": { "compartment": "compartment_876", "id": "reaction_10685511", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10685508", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10697358": { "compartment": "compartment_984", "id": "reaction_10697358", "reactome": "R-DDI-2395302", "name": "Formation of hydroxylysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697305" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696943": { "compartment": "compartment_984", "id": "reaction_10696943", "reactome": "R-DDI-2213210", "name": "Collagen IX is cross-linked to the surface of collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696939", "species_10691415" ], "products": [ "species_10696941" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10698054": { "compartment": "compartment_984", "id": "reaction_10698054", "reactome": "R-DDI-2559639", "name": "Collagen type IV sulfilimine cross-linking by peroxidasin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_351629" ], "products": [ "species_10698047" ], "modifiers": [ [ "species_10698051", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q6TMK4", "DDB_G0277275", "CHEBI:15858" ] }, "reaction_10697211": { "compartment": "compartment_984", "id": "reaction_10697211", "reactome": "R-DDI-2250301", "name": "Formation of lysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697099" ], "products": [ "species_10697209" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696855": { "compartment": "compartment_984", "id": "reaction_10696855", "reactome": "R-DDI-2213207", "name": "Formation of collagen networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696849" ], "products": [ "species_10696853" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697334": { "compartment": "compartment_984", "id": "reaction_10697334", "reactome": "R-DDI-2395257", "name": "Formation of dehydro-hydroxylysino-norleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10694584" ], "products": [ "species_10697099" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697103": { "compartment": "compartment_984", "id": "reaction_10697103", "reactome": "R-DDI-2243926", "name": "Formation of histidino-hydroxylysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676611", "species_10697099" ], "products": [ "species_10697101" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696859": { "compartment": "compartment_984", "id": "reaction_10696859", "reactome": "R-DDI-2213208", "name": "Type X collagen associates with collagen type II fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696851", "species_10691415" ], "products": [ "species_10696857" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697360": { "compartment": "compartment_984", "id": "reaction_10697360", "reactome": "R-DDI-2395314", "name": "Formation of lysino-5-ketonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697356", "species_10676611" ], "products": [ "species_10697183" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697250": { "compartment": "compartment_984", "id": "reaction_10697250", "reactome": "R-DDI-2299620", "name": "Collagen XI cross-links with collagen II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691593", "species_10691415" ], "products": [ "species_10697248" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697332": { "compartment": "compartment_984", "id": "reaction_10697332", "reactome": "R-DDI-2395223", "name": "Formation of hydroxylysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305" ], "products": [ "species_10697330" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697414": { "compartment": "compartment_984", "id": "reaction_10697414", "reactome": "R-DDI-2395324", "name": "Formation of hydroxylysyl-pyrrole cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697305", "species_10697099" ], "products": [ "species_10697412" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697166": { "compartment": "compartment_984", "id": "reaction_10697166", "reactome": "R-DDI-2243931", "name": "Formation of dehydro-lysinonorleucine cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694584", "species_10676611" ], "products": [ "species_10697164" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697387": { "compartment": "compartment_984", "id": "reaction_10697387", "reactome": "R-DDI-2395322", "name": "Formation of lysyl-pyridinoline cross-links", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697183", "species_10697305" ], "products": [ "species_10697385" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10696823": { "compartment": "compartment_984", "id": "reaction_10696823", "reactome": "R-DDI-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691599" ], "products": [ "species_10696821" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10691601": { "compartment": "compartment_984", "id": "reaction_10691601", "reactome": "R-DDI-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10691589" ], "products": [ "species_10691599" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10676916": { "compartment": "compartment_7660", "id": "reaction_10676916", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670658" ], "products": [ "species_113582", "species_10676914" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0274503" ] }, "reaction_10676895": { "compartment": "compartment_7660", "id": "reaction_10676895", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10676887" ], "products": [ "species_29370", "species_10676890" ], "modifiers": [ [ "species_10676892", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10677114": { "compartment": "compartment_7660", "id": "reaction_10677114", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10677109" ], "products": [ "species_113582", "species_10677112" ], "modifiers": [ [ "species_10676882", "catalyst" ] ], "additional_components": [ "DDB_G0291842", "DDB_G0291842", "DDB_G0274503" ] }, "reaction_10697270": { "compartment": "compartment_984", "id": "reaction_10697270", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697266", "species_10695841" ], "products": [ "species_10697268" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485" ] }, "reaction_10695849": { "compartment": "compartment_984", "id": "reaction_10695849", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695819" ], "products": [ "species_10695847" ], "modifiers": [], "additional_components": [ "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485" ] }, "reaction_10724643": { "compartment": "compartment_70101", "id": "reaction_10724643", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724639", "species_10676232" ], "products": [ "species_10724641" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10724634": { "compartment": "compartment_70101", "id": "reaction_10724634", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724627", "species_113592" ], "products": [ "species_29370", "species_10724631" ], "modifiers": [ [ "species_10724627", "catalyst" ] ], "additional_components": [ "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10726201": { "compartment": "compartment_7660", "id": "reaction_10726201", "reactome": "R-DDI-9754130", "name": "CDK4 inhibitors bind CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9754127", "species_10670762" ], "products": [ "species_10670773" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680" ] }, "reaction_10723600": { "compartment": "compartment_7660", "id": "reaction_10723600", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698648", "species_10670680" ], "products": [ "species_10723598" ], "modifiers": [ [ "species_10670387", "inhibitor" ], [ "species_10670764", "inhibitor" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10721692": { "compartment": "compartment_7660", "id": "reaction_10721692", "reactome": "R-DDI-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10721688" ], "products": [ "species_113582", "species_10670764" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10670637": { "compartment": "compartment_70101", "id": "reaction_10670637", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670633", "species_10670619" ], "products": [ "species_10670635" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690366": { "compartment": "compartment_7660", "id": "reaction_10690366", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690027" ], "products": [ "species_113550", "species_10690019" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678594": { "compartment": "compartment_70101", "id": "reaction_10678594", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678224", "species_10670619" ], "products": [ "species_10678592" ], "modifiers": [], "additional_components": [ "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0272813", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10676508": { "compartment": "compartment_7660", "id": "reaction_10676508", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10676480", "species_113656" ], "products": [ "species_113550", "species_10676482" ], "modifiers": [ [ "species_10676505", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10670666": { "compartment": "compartment_7660", "id": "reaction_10670666", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_113582", "species_10670646" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10721690": { "compartment": "compartment_13231", "id": "reaction_10721690", "reactome": "R-DDI-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721670" ], "products": [ "species_10721688" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10678230": { "compartment": "compartment_13231", "id": "reaction_10678230", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678226" ], "products": [ "species_10678228" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10670783": { "compartment": "compartment_7660", "id": "reaction_10670783", "reactome": "R-DDI-69227", "name": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670680" ], "products": [ "species_113582", "species_10670683" ], "modifiers": [ [ "species_10670764", "catalyst" ], [ "species_10670773", "inhibitor" ], [ "species_10670781", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=7938", "LigandDisplayForward?ligandId=5950", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=5707", "LigandDisplayForward?ligandId=7744", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "pubchem.compound:9933545", "LigandDisplayForward?ligandId=8203", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=5680", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10698510": { "compartment": "compartment_70101", "id": "reaction_10698510", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676892" ], "products": [ "species_10676882" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10678242": { "compartment": "compartment_13231", "id": "reaction_10678242", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678238" ], "products": [ "species_10678240" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10679206": { "compartment": "compartment_7660", "id": "reaction_10679206", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679202", "species_10669684" ], "products": [ "species_10679204" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10717991": { "compartment": "compartment_70101", "id": "reaction_10717991", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717986" ], "products": [ "species_10670153", "species_10717891" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10718380": { "compartment": "compartment_7660", "id": "reaction_10718380", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10718364" ], "products": [ "species_10690363", "species_8857797" ], "modifiers": [ [ "species_10718377", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0281651" ] }, "reaction_10696428": { "compartment": "compartment_7660", "id": "reaction_10696428", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696414", "species_29358" ], "products": [ "species_113582", "species_10696417" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10678234": { "compartment": "compartment_13231", "id": "reaction_10678234", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676890" ], "products": [ "species_10678232" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10697660": { "compartment": "compartment_7660", "id": "reaction_10697660", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697640", "species_113560" ], "products": [ "species_2485002", "species_10697648" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10690017": { "compartment": "compartment_7660", "id": "reaction_10690017", "reactome": "R-DDI-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690008", "species_29358" ], "products": [ "species_113582", "species_10690015", "species_10690013" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10726199": { "compartment": "compartment_7660", "id": "reaction_10726199", "reactome": "R-DDI-9754129", "name": "CDK6 inhibitors bind CDK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670751", "species_9754132" ], "products": [ "species_10670781" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=10426", "LigandDisplayForward?ligandId=9923", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=7934", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=9923", "Q8T2F2", "DDB_G0277439", "LigandDisplayForward?ligandId=11189", "LigandDisplayForward?ligandId=7380", "LigandDisplayForward?ligandId=5969", "LigandDisplayForward?ligandId=10313", "LigandDisplayForward?ligandId=7379", "LigandDisplayForward?ligandId=10426", "P34112", "DDB_G0272813", "Q1ZXI1", "DDB_G0279085", "LigandDisplayForward?ligandId=9626", "LigandDisplayForward?ligandId=7383", "LigandDisplayForward?ligandId=7382", "LigandDisplayForward?ligandId=7934" ] }, "reaction_10717895": { "compartment": "compartment_70101", "id": "reaction_10717895", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678761", "species_10717891" ], "products": [ "species_10717893" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10679247": { "compartment": "compartment_7660", "id": "reaction_10679247", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10670641" ], "products": [ "species_10670387", "species_113582" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10677004": { "compartment": "compartment_13231", "id": "reaction_10677004", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670635" ], "products": [ "species_10670641" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10717989": { "compartment": "compartment_70101", "id": "reaction_10717989", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10717893" ], "products": [ "species_10717986" ], "modifiers": [ [ "species_10717893", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54K33", "DDB_G0287629", "Q54WX4", "DDB_G0279343", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629" ] }, "reaction_10690392": { "compartment": "compartment_7660", "id": "reaction_10690392", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679187", "species_10690013" ], "products": [ "species_10690390" ], "modifiers": [], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "DDB_G0290551", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10690031": { "compartment": "compartment_7660", "id": "reaction_10690031", "reactome": "R-DDI-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10690021" ], "products": [ "species_113582", "species_10690027", "species_10690029" ], "modifiers": [ [ "species_10670764", "catalyst" ] ], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679253": { "compartment": "compartment_7660", "id": "reaction_10679253", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670387", "species_10670683" ], "products": [ "species_10679251" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10679256": { "compartment": "compartment_7660", "id": "reaction_10679256", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679251" ], "products": [ "species_113582", "species_10670387", "species_10676480" ], "modifiers": [ [ "species_10679251", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54FX2", "DDB_G0290551" ] }, "reaction_10697703": { "compartment": "compartment_7660", "id": "reaction_10697703", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697699", "species_113560" ], "products": [ "species_2485002", "species_10697701" ], "modifiers": [ [ "species_10697657", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q552Q7", "DDB_G0275929", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54W25", "DDB_G0279959" ] }, "reaction_10697598": { "compartment": "compartment_70101", "id": "reaction_10697598", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697587" ], "products": [ "species_10697595" ], "modifiers": [ [ "species_10697587", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10670675": { "compartment": "compartment_7660", "id": "reaction_10670675", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10670646" ], "products": [ "species_113550", "species_10670641" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10725467": { "compartment": "compartment_70101", "id": "reaction_10725467", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725465" ], "products": [ "species_10670680" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10679227": { "compartment": "compartment_7660", "id": "reaction_10679227", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679204", "species_29358" ], "products": [ "species_113582", "species_10679224" ], "modifiers": [ [ "species_10679204", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54Q23", "DDB_G0284129" ] }, "reaction_10678793": { "compartment": "compartment_7660", "id": "reaction_10678793", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678789", "species_113518" ], "products": [ "species_113550", "species_10678791" ], "modifiers": [ [ "species_10670672", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "DDB_G0283617" ] }, "reaction_10697034": { "compartment": "compartment_20699", "id": "reaction_10697034", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697026", "species_113592" ], "products": [ "species_29370", "species_10697031" ], "modifiers": [ [ "species_10697026", "catalyst" ] ], "additional_components": [ "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "Q54SV1", "DDB_G0282203", "Q54NU2", "DDB_G0284985", "P34140", "DDB_G0277867", "Q54DF4", "DDB_G0292300", "P34139", "DDB_G0283757", "Q552K3", "DDB_G0275969", "Q54EW9", "DDB_G0291293", "species_29438", "P34141", "DDB_G0291233", "Q86HN7", "DDB_G0274503", "Q54C46", "DDB_G0293248" ] }, "reaction_10697509": { "compartment": "compartment_7660", "id": "reaction_10697509", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697504", "species_29358" ], "products": [ "species_113582", "species_10697507" ], "modifiers": [ [ "species_10696425", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0276157" ] }, "reaction_10721628": { "compartment": "compartment_70101", "id": "reaction_10721628", "reactome": "R-DDI-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674818", "species_10721624" ], "products": [ "species_10721626" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10718372": { "compartment": "compartment_7660", "id": "reaction_10718372", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690363", "species_77087" ], "products": [ "species_10718364", "species_77502" ], "modifiers": [ [ "species_10718369", "catalyst" ] ], "additional_components": [ "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "DDB_G0288271" ] }, "reaction_10690397": { "compartment": "compartment_7660", "id": "reaction_10690397", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10690390", "species_10669917" ], "products": [ "species_10679187", "species_10690394" ], "modifiers": [ [ "species_10690390", "catalyst" ] ], "additional_components": [ "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q54FX2", "DDB_G0290551", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642" ] }, "reaction_10676510": { "compartment": "compartment_7660", "id": "reaction_10676510", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670361" ], "products": [ "species_10669535", "species_113656" ], "modifiers": [], "additional_components": [ "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q55BM5", "DDB_G0270442", "Q54MM7", "DDB_G0285853", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191" ] }, "reaction_10679215": { "compartment": "compartment_7660", "id": "reaction_10679215", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10669684" ], "modifiers": [ [ "species_10673933", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q54I13", "DDB_G0289079" ] }, "reaction_10679212": { "compartment": "compartment_7660", "id": "reaction_10679212", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10679208" ], "products": [ "species_113582", "species_10679210" ], "modifiers": [ [ "species_10669684", "catalyst" ] ], "additional_components": [ "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10679193": { "compartment": "compartment_7660", "id": "reaction_10679193", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10679191" ], "products": [ "species_10679187", "species_10670389", "species_10669917" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q8T2F2", "DDB_G0277439", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q9XZJ3", "DDB_G0267384", "P14797", "DDB_G0276765", "Q557E4", "DDB_G0273251", "P34112", "DDB_G0272813", "P52285", "DDB_G0269230", "P0CG80", "DDB_G0291928", "Q1ZXI1", "DDB_G0279085", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "B0G102", "DDB_G0271642", "P14794", "DDB_G0280755", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "B0G102", "DDB_G0271642", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10678870": { "compartment": "compartment_13231", "id": "reaction_10678870", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678592" ], "products": [ "species_10678791" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085" ] }, "reaction_10690368": { "compartment": "compartment_7660", "id": "reaction_10690368", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10690013" ], "products": [ "species_113550", "species_10689991" ], "modifiers": [ [ "species_10690363", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551", "Q54W95", "DDB_G0279813", "Q54Q99", "DDB_G0283905", "Q54BX1", "DDB_G0293386", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601" ] }, "reaction_10678849": { "compartment": "compartment_7660", "id": "reaction_10678849", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10678791" ], "products": [ "species_113582", "species_10678789" ], "modifiers": [ [ "species_10670658", "catalyst" ], [ "species_10670664", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "Q1ZXI1", "DDB_G0279085", "Q54ZN3", "DDB_G0282417", "Q54SK3", "DDB_G0282417", "DDB_G0302543" ] }, "reaction_10697448": { "compartment": "compartment_984", "id": "reaction_10697448", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697444", "species_10692323" ], "products": [ "species_10697446" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q54LD6", "DDB_G0286691", "Q55E77", "DDB_G0270488" ] }, "reaction_10721829": { "compartment": "compartment_17957", "id": "reaction_10721829", "reactome": "R-DDI-8948234", "name": "P4HB:4-Hyp collagen propeptides dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692649" ], "products": [ "species_10692647", "species_10692513" ], "modifiers": [], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0280773" ] }, "reaction_10721764": { "compartment": "compartment_17957", "id": "reaction_10721764", "reactome": "R-DDI-8944246", "name": "Association of procollagen type XXI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695220" ], "products": [ "species_10695222" ], "modifiers": [], "additional_components": [ "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721774": { "compartment": "compartment_17957", "id": "reaction_10721774", "reactome": "R-DDI-8944265", "name": "Association of procollagen type IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694722", "species_10694792", "species_10694768", "species_10694746", "species_10694814", "species_10694700" ], "products": [ "species_10694818" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694524": { "compartment": "compartment_17957", "id": "reaction_10694524", "reactome": "R-DDI-2002460", "name": "P4HB binds Collagen chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692579", "species_10692513" ], "products": [ "species_10692581" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "DDB_G0280773", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721748": { "compartment": "compartment_17957", "id": "reaction_10721748", "reactome": "R-DDI-8944223", "name": "Association of procollagen type V", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694886", "species_10694840", "species_10694862" ], "products": [ "species_10694892" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721766": { "compartment": "compartment_17957", "id": "reaction_10721766", "reactome": "R-DDI-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695286" ], "products": [ "species_10695288" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721776": { "compartment": "compartment_17957", "id": "reaction_10721776", "reactome": "R-DDI-8944266", "name": "Association of procollagen type XI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695072", "species_10694652", "species_10695050" ], "products": [ "species_10695074" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721742": { "compartment": "compartment_17957", "id": "reaction_10721742", "reactome": "R-DDI-8944218", "name": "Association of procollagen type VIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694914", "species_10694936" ], "products": [ "species_10694938" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721738": { "compartment": "compartment_17957", "id": "reaction_10721738", "reactome": "R-DDI-8944214", "name": "Association of procollagen type I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694606", "species_10694628" ], "products": [ "species_10694630" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721772": { "compartment": "compartment_17957", "id": "reaction_10721772", "reactome": "R-DDI-8944263", "name": "Association of procollagen type II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694652" ], "products": [ "species_10694654" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10697502": { "compartment": "compartment_984", "id": "reaction_10697502", "reactome": "R-DDI-2426450", "name": "Laminins:Nidogens binds collagen type IV networks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692249", "species_10697498" ], "products": [ "species_10697500" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10721768": { "compartment": "compartment_17957", "id": "reaction_10721768", "reactome": "R-DDI-8944261", "name": "Association of procollagen type XIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695096" ], "products": [ "species_10695098" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721750": { "compartment": "compartment_17957", "id": "reaction_10721750", "reactome": "R-DDI-8944225", "name": "Association of procollagen type XVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695168" ], "products": [ "species_10695170" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721752": { "compartment": "compartment_17957", "id": "reaction_10721752", "reactome": "R-DDI-8944227", "name": "Association of procollagen type XXII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695240" ], "products": [ "species_10695242" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700154": { "compartment": "compartment_984", "id": "reaction_10700154", "reactome": "R-DDI-4084507", "name": "Laminin-111 binds endostatin dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700150", "species_10697474" ], "products": [ "species_10700152" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488", "Q54QY4", "DDB_G0283585", "Q55E77", "DDB_G0270488" ] }, "reaction_10693910": { "compartment": "compartment_17957", "id": "reaction_10693910", "reactome": "R-DDI-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10693906" ], "products": [ "species_10693908" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721746": { "compartment": "compartment_17957", "id": "reaction_10721746", "reactome": "R-DDI-8944220", "name": "Association of procollagen type XXIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695262" ], "products": [ "species_10695264" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10694522": { "compartment": "compartment_984", "id": "reaction_10694522", "reactome": "R-DDI-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694218" ], "products": [ "species_10694510" ], "modifiers": [ [ "species_10694515", "catalyst" ] ], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585", "DDB_G0279795" ] }, "reaction_10696111": { "compartment": "compartment_17957", "id": "reaction_10696111", "reactome": "R-DDI-2152276", "name": "Secretion of transmembrane collagens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10696025" ], "products": [ "species_10696109" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721762": { "compartment": "compartment_17957", "id": "reaction_10721762", "reactome": "R-DDI-8944242", "name": "Association of procollagen type XXVII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695310" ], "products": [ "species_10695312" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10700148": { "compartment": "compartment_984", "id": "reaction_10700148", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700144", "species_10692323" ], "products": [ "species_10700146" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10721760": { "compartment": "compartment_17957", "id": "reaction_10721760", "reactome": "R-DDI-8944240", "name": "Association of procollagen type III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10694676" ], "products": [ "species_10694678" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721770": { "compartment": "compartment_17957", "id": "reaction_10721770", "reactome": "R-DDI-8944262", "name": "Association of procollagen type X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695026" ], "products": [ "species_10695028" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10721740": { "compartment": "compartment_17957", "id": "reaction_10721740", "reactome": "R-DDI-8944216", "name": "Association of procollagen type XV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695120" ], "products": [ "species_10695122" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10692690": { "compartment": "compartment_17957", "id": "reaction_10692690", "reactome": "R-DDI-1650808", "name": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1650779", "species_113534", "species_10692581" ], "products": [ "species_159751", "species_1650769", "species_10692649" ], "modifiers": [ [ "species_10692687", "catalyst" ] ], "additional_components": [ "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "Q54QY4", "DDB_G0283585", "Q54UW6", "DDB_G0280773", "CHEBI:29073", "Q553P3", "DDB_G0292888", "Q54N51", "DDB_G0292888", "species_71067", "Q54TF2", "DDB_G0292888", "Q54CK1", "DDB_G0292888" ] }, "reaction_10721744": { "compartment": "compartment_17957", "id": "reaction_10721744", "reactome": "R-DDI-8944219", "name": "Association of procollagen type XVI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10695144" ], "products": [ "species_10695146" ], "modifiers": [], "additional_components": [ "Q54QY4", "DDB_G0283585", "Q54QY4", "DDB_G0283585" ] }, "reaction_10724718": { "compartment": "compartment_876", "id": "reaction_10724718", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10683798", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10675991": { "compartment": "compartment_7660", "id": "reaction_10675991", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675987", "species_10675982" ], "products": [ "species_10675989" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q54S00", "DDB_G0282747", "Q55AZ3", "DDB_G0271608" ] }, "reaction_10703141": { "compartment": "compartment_7660", "id": "reaction_10703141", "reactome": "R-DDI-5653766", "name": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703137", "species_10703104" ], "products": [ "species_10703139" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0275021", "Q54TK0", "DDB_G0281703", "Q54CI1", "DDB_G0292984", "Q54KS3", "DDB_G0287149", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD4", "DDB_G0286027", "Q54K47", "DDB_G0287607", "Q54BN3", "DDB_G0293702", "O96612", "DDB_G0275021", "Q54E21", "DDB_G0291868", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "P0CG79", "DDB_G0282369", "Q54MH9", "DDB_G0285961", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10675750": { "compartment": "compartment_70101", "id": "reaction_10675750", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10677294": { "compartment": "compartment_70616", "id": "reaction_10677294", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113592", "species_113581" ], "modifiers": [ [ "species_10677291", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10686888": { "compartment": "compartment_70101", "id": "reaction_10686888", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686865": { "compartment": "compartment_70101", "id": "reaction_10686865", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10686862", "catalyst" ] ], "additional_components": [ "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "species_159362", "species_209789", "species_83909", "CHEBI:28918", "species_209914", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675741": { "compartment": "compartment_70101", "id": "reaction_10675741", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686918": { "compartment": "compartment_20699", "id": "reaction_10686918", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10686876": { "compartment": "compartment_70101", "id": "reaction_10686876", "reactome": "R-DDI-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10686873", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "species_5635947", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10686884": { "compartment": "compartment_20699", "id": "reaction_10686884", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10686881", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10687053": { "compartment": "compartment_876", "id": "reaction_10687053", "reactome": "R-DDI-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10687050", "catalyst" ] ], "additional_components": [ "species_209937", "species_176667", "species_209937", "species_176667", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10686921": { "compartment": "compartment_20699", "id": "reaction_10686921", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10686915", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10675743": { "compartment": "compartment_70101", "id": "reaction_10675743", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10675738", "catalyst" ] ], "additional_components": [ "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "species_113599", "species_83960", "species_29554", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_5635947", "species_83909", "CHEBI:16040", "CHEBI:16750", "species_83956", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10675748": { "compartment": "compartment_70101", "id": "reaction_10675748", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10675745", "catalyst" ] ], "additional_components": [ "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "species_83928", "species_83921", "CHEBI:17562", "CHEBI:16704", "species_83909", "CHEBI:16750", "Q54TT3", "DDB_G0281515", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0281515" ] }, "reaction_10682847": { "compartment": "compartment_876", "id": "reaction_10682847", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682581": { "compartment": "compartment_876", "id": "reaction_10682581", "reactome": "R-DDI-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10682578", "catalyst" ] ], "additional_components": [ "species_351993", "species_29500", "species_352030", "species_351993", "species_29500", "species_352030", "Q555W6", "DDB_G0274807", "Q556Y5", "DDB_G0274807" ] }, "reaction_10682845": { "compartment": "compartment_876", "id": "reaction_10682845", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682842", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "DDB_G0279983" ] }, "reaction_10682821": { "compartment": "compartment_876", "id": "reaction_10682821", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682818", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10682840": { "compartment": "compartment_876", "id": "reaction_10682840", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10682837", "catalyst" ] ], "additional_components": [ "species_113585", "species_29444", "species_29468", "species_113585", "species_29444", "species_29468", "Q54KK3", "DDB_G0346922", "Q54W03", "DDB_G0279983", "Q54KK2", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54EJ9", "DDB_G0291227" ] }, "reaction_10722317": { "compartment": "compartment_7660", "id": "reaction_10722317", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690002" ], "products": [ "species_10722315" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722398": { "compartment": "compartment_7660", "id": "reaction_10722398", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722315", "species_10722394" ], "products": [ "species_10722396" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54JZ0", "DDB_G0287727", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722387": { "compartment": "compartment_7660", "id": "reaction_10722387", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722313", "species_10690004" ], "products": [ "species_10722385" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10722987": { "compartment": "compartment_7660", "id": "reaction_10722987", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10722313" ], "products": [ "species_113582", "species_10722985" ], "modifiers": [ [ "species_10670810", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10688476": { "compartment": "compartment_7660", "id": "reaction_10688476", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10688251", "species_10688256" ], "products": [ "species_10688474" ], "modifiers": [], "additional_components": [ "DDB_G0285989", "DDB_G0281085", "Q54UG9", "DDB_G0281085", "Q54MF7", "DDB_G0285989" ] }, "reaction_10709807": { "compartment": "compartment_7660", "id": "reaction_10709807", "reactome": "R-DDI-5693540", "name": "MRN activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704976", "species_29358" ], "products": [ "species_113582", "species_10709804", "species_10682355" ], "modifiers": [ [ "species_10704976", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703096": { "compartment": "compartment_7660", "id": "reaction_10703096", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703089" ], "products": [ "species_10703093" ], "modifiers": [ [ "species_10703089", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10709844": { "compartment": "compartment_7660", "id": "reaction_10709844", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709797", "species_10705273" ], "products": [ "species_10709799" ], "modifiers": [], "additional_components": [ "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10702975": { "compartment": "compartment_7660", "id": "reaction_10702975", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10702970" ], "products": [ "species_10702972", "species_113550" ], "modifiers": [ [ "species_10702970", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705284": { "compartment": "compartment_7660", "id": "reaction_10705284", "reactome": "R-DDI-5682967", "name": "WHSC1 binds DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700897", "species_10705275" ], "products": [ "species_10705282" ], "modifiers": [], "additional_components": [ "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676006": { "compartment": "compartment_7660", "id": "reaction_10676006", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675974", "species_10675996" ], "products": [ "species_10675968", "species_10675998" ], "modifiers": [], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "DDB_G0277701", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10703099": { "compartment": "compartment_7660", "id": "reaction_10703099", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10703074" ], "products": [ "species_10703028", "species_5651834" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10711334": { "compartment": "compartment_7660", "id": "reaction_10711334", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709581", "species_10711318" ], "products": [ "species_10698305", "species_10711329" ], "modifiers": [ [ "species_10711331", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "DDB_G0287693", "Q8N0B4", "DDB_G0286189", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FZ7", "DDB_G0267886", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q869L7", "DDB_G0279421", "Q54TK0", "DDB_G0281703", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54SX2", "DDB_G0282161", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10710378": { "compartment": "compartment_7660", "id": "reaction_10710378", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710373", "species_113518" ], "products": [ "species_10675845", "species_10669917" ], "modifiers": [ [ "species_10710375", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0267682", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0274207" ] }, "reaction_10725845": { "compartment": "compartment_7660", "id": "reaction_10725845", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710820", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10710831" ], "modifiers": [ [ "species_10710820", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10674796": { "compartment": "compartment_7660", "id": "reaction_10674796", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674787", "species_10674792" ], "products": [ "species_10674794" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54BN2", "DDB_G0293546" ] }, "reaction_10710837": { "compartment": "compartment_7660", "id": "reaction_10710837", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710833", "species_10675852" ], "products": [ "species_10710835" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709584": { "compartment": "compartment_7660", "id": "reaction_10709584", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709577", "species_29358" ], "products": [ "species_113582", "species_113550", "species_10709581" ], "modifiers": [ [ "species_10709577", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10710592": { "compartment": "compartment_7660", "id": "reaction_10710592", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710586", "species_10703028" ], "products": [ "species_10710588" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10674087": { "compartment": "compartment_7660", "id": "reaction_10674087", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674080" ], "products": [ "species_10674084" ], "modifiers": [ [ "species_10674080", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10705287": { "compartment": "compartment_7660", "id": "reaction_10705287", "reactome": "R-DDI-5682983", "name": "ATM phosphorylates WHSC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10705282" ], "products": [ "species_113582", "species_10705277" ], "modifiers": [ [ "species_10705282", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709814": { "compartment": "compartment_7660", "id": "reaction_10709814", "reactome": "R-DDI-5693566", "name": "TP53BP1 associates with H4K20Me2 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705317", "species_10698412" ], "products": [ "species_10705325" ], "modifiers": [], "additional_components": [ "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0286539", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10676004": { "compartment": "compartment_7660", "id": "reaction_10676004", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675996", "species_10675953" ], "products": [ "species_10675947", "species_10675998" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10705333": { "compartment": "compartment_7660", "id": "reaction_10705333", "reactome": "R-DDI-5683425", "name": "ATM phosphorylates TP53BP1 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705325", "species_29358" ], "products": [ "species_113582", "species_10705323" ], "modifiers": [ [ "species_10705325", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10710857": { "compartment": "compartment_7660", "id": "reaction_10710857", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710853", "species_10710851", "species_10670546", "species_10710839" ], "products": [ "species_10710855" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54K47", "DDB_G0287607", "Q54RD4", "DDB_G0283189", "Q54KS3", "DDB_G0287149", "Q54Y85", "DDB_G0278367", "Q54TN8", "DDB_G0281641", "Q7KWN0", "DDB_G0272740", "Q54N97", "DDB_G0285381", "B0G131", "DDB_G0294609", "Q75JQ9", "DDB_G0272222", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MH9", "DDB_G0285961", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q54N41", "DDB_G0285521", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54BN3", "DDB_G0293702", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q54Y85", "DDB_G0278367", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54RD4", "DDB_G0283189", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q54ST4", "DDB_G0282235", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10709802": { "compartment": "compartment_7660", "id": "reaction_10709802", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709799" ], "products": [ "species_113582", "species_10705275" ], "modifiers": [ [ "species_10709799", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690" ] }, "reaction_10676017": { "compartment": "compartment_7660", "id": "reaction_10676017", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010", "species_10674064" ], "products": [ "species_10676015" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10703020": { "compartment": "compartment_7660", "id": "reaction_10703020", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676029", "species_10674064" ], "products": [ "species_10676031" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10676000": { "compartment": "compartment_7660", "id": "reaction_10676000", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675902", "species_10675996" ], "products": [ "species_10675896", "species_10675998" ], "modifiers": [], "additional_components": [ "P53766", "DDB_G0277877", "DDB_G0277701", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10703083": { "compartment": "compartment_7660", "id": "reaction_10703083", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703076" ], "products": [ "species_10703074", "species_10703081" ], "modifiers": [], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10709648": { "compartment": "compartment_7660", "id": "reaction_10709648", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688114", "species_10709644", "species_10709590" ], "products": [ "species_10709646", "species_10709642" ], "modifiers": [], "additional_components": [ "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54CS2", "DDB_G0292794", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54QX3", "DDB_G0283587", "Q54PF3", "DDB_G0284597", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10710842": { "compartment": "compartment_7660", "id": "reaction_10710842", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710835" ], "products": [ "species_10710839" ], "modifiers": [ [ "species_10710835", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55GG6", "DDB_G0267682", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54AQ1", "DDB_G0294290", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55GG6", "DDB_G0267682", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54PN5", "DDB_G0284419", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10676020": { "compartment": "compartment_7660", "id": "reaction_10676020", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676015" ], "products": [ "species_10675996", "species_10674091", "species_30977" ], "modifiers": [ [ "species_10676015", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10705280": { "compartment": "compartment_7660", "id": "reaction_10705280", "reactome": "R-DDI-5682965", "name": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705277", "species_77087" ], "products": [ "species_10705231", "species_77502" ], "modifiers": [ [ "species_10705277", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132" ] }, "reaction_10675854": { "compartment": "compartment_7660", "id": "reaction_10675854", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675845", "species_10675850" ], "products": [ "species_10675852" ], "modifiers": [], "additional_components": [ "DDB_G0267682", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10703037": { "compartment": "compartment_7660", "id": "reaction_10703037", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676035", "species_10703028", "species_10670606" ], "products": [ "species_10703030", "species_10675996" ], "modifiers": [ [ "species_10703035", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54XI2", "DDB_G0278741", "DDB_G0284987", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "DDB_G0277701", "DDB_G0277943" ] }, "reaction_10725405": { "compartment": "compartment_70101", "id": "reaction_10725405", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725401" ], "products": [ "species_10725403" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10709812": { "compartment": "compartment_7660", "id": "reaction_10709812", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10709809" ], "products": [ "species_113582", "species_10705388" ], "modifiers": [ [ "species_10709809", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10703045": { "compartment": "compartment_7660", "id": "reaction_10703045", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10703030" ], "products": [ "species_10703042", "species_113541" ], "modifiers": [ [ "species_10703030", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10676013": { "compartment": "compartment_7660", "id": "reaction_10676013", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675998" ], "products": [ "species_10676010" ], "modifiers": [ [ "species_10675998", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10702985": { "compartment": "compartment_7660", "id": "reaction_10702985", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702977" ], "products": [ "species_10702982" ], "modifiers": [ [ "species_10702977", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10705330": { "compartment": "compartment_7660", "id": "reaction_10705330", "reactome": "R-DDI-5683405", "name": "PPP5C dephosphorylates TP53BP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10705323" ], "products": [ "species_10705325", "species_113550" ], "modifiers": [ [ "species_10705327", "catalyst" ] ], "additional_components": [ "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "Q54LN0", "DDB_G0286539", "species_29426", "Q8N0B4", "DDB_G0286189", "Q54HV9", "DDB_G0289193", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54D06", "DDB_G0292596", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q55FZ7", "DDB_G0267886", "Q86IG6", "DDB_G0272690", "Q55FF7", "DDB_G0268132", "DDB_G0283157" ] }, "reaction_10702980": { "compartment": "compartment_7660", "id": "reaction_10702980", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702972", "species_30555" ], "products": [ "species_113541", "species_10702977" ], "modifiers": [ [ "species_10702972", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q54U78", "DDB_G0281229" ] }, "reaction_10703079": { "compartment": "compartment_7660", "id": "reaction_10703079", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10703042" ], "products": [ "species_10703076", "species_427497" ], "modifiers": [ [ "species_10703042", "catalyst" ] ], "additional_components": [ "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q55GU8", "DDB_G0267468", "Q54X55", "DDB_G0279195", "Q54HY5", "DDB_G0289141", "Q54NU0", "DDB_G0284987", "Q54XI2", "DDB_G0278741" ] }, "reaction_10710590": { "compartment": "compartment_7660", "id": "reaction_10710590", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710588", "species_427523" ], "products": [ "species_427497", "species_10709573" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10705265": { "compartment": "compartment_7660", "id": "reaction_10705265", "reactome": "R-DDI-5682629", "name": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705253", "species_10705259" ], "products": [ "species_10705263" ], "modifiers": [], "additional_components": [ "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "species_29426", "Q54HV9", "DDB_G0289193", "Q8N0B4", "DDB_G0286189", "Q86K32", "DDB_G0277267", "Q555X5", "DDB_G0274743", "Q54WG6", "DDB_G0279667", "Q54D06", "DDB_G0292596", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q54V57", "DDB_G0280603", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758", "Q86IG6", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q55FF7", "DDB_G0268132" ] }, "reaction_10709592": { "compartment": "compartment_7660", "id": "reaction_10709592", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709562", "species_10700619", "species_10700558" ], "products": [ "species_10709590" ], "modifiers": [], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54WU9", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10709847": { "compartment": "compartment_7660", "id": "reaction_10709847", "reactome": "R-DDI-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709804", "species_29358" ], "products": [ "species_113582", "species_10705206" ], "modifiers": [ [ "species_10709804", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703207": { "compartment": "compartment_7660", "id": "reaction_10703207", "reactome": "R-DDI-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703190" ], "products": [ "species_10703202", "species_10703204", "species_10703188" ], "modifiers": [ [ "species_10703190", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "DDB_G0290453", "DDB_G0290453", "DDB_G0277533", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453" ] }, "reaction_10676002": { "compartment": "compartment_7660", "id": "reaction_10676002", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675918", "species_10675996" ], "products": [ "species_10675889", "species_10675998" ], "modifiers": [], "additional_components": [ "Q86K43", "DDB_G0277247", "DDB_G0277701", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10703022": { "compartment": "compartment_7660", "id": "reaction_10703022", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676010" ], "products": [ "species_10676029" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10676038": { "compartment": "compartment_7660", "id": "reaction_10676038", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676031", "species_30555" ], "products": [ "species_10676035", "species_113541" ], "modifiers": [ [ "species_10676031", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10709851": { "compartment": "compartment_7660", "id": "reaction_10709851", "reactome": "R-DDI-5693602", "name": "ATM recognizes H2AFX-Nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705374", "species_10705206" ], "products": [ "species_10709809" ], "modifiers": [], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "Q54HV9", "DDB_G0289193", "Q54WG6", "DDB_G0279667", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q54LP8", "DDB_G0286509", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "O15819", "DDB_G0267402", "Q54BC2", "DDB_G0293758" ] }, "reaction_10674096": { "compartment": "compartment_7660", "id": "reaction_10674096", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10674093" ], "products": [ "species_113541", "species_10674080" ], "modifiers": [ [ "species_10674093", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710877": { "compartment": "compartment_7660", "id": "reaction_10710877", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709646", "species_10669917" ], "products": [ "species_10710586" ], "modifiers": [ [ "species_10709646", "catalyst" ] ], "additional_components": [ "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q869L7", "DDB_G0279421", "Q54CS2", "DDB_G0292794", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54WU9", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357" ] }, "reaction_10704979": { "compartment": "compartment_7660", "id": "reaction_10704979", "reactome": "R-DDI-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704974", "species_113560" ], "products": [ "species_2485002", "species_10704976" ], "modifiers": [ [ "species_10704974", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10703091": { "compartment": "compartment_7660", "id": "reaction_10703091", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703087", "species_10670614" ], "products": [ "species_10703089" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493" ] }, "reaction_10710823": { "compartment": "compartment_7660", "id": "reaction_10710823", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10710797" ], "products": [ "species_113582", "species_10710820", "species_113550" ], "modifiers": [ [ "species_10710797", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "P35084", "DDB_G0279193", "Q54TY2", "DDB_G0281441", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54X62", "DDB_G0279177", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q869U4", "DDB_G0276443", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "P0CG79", "DDB_G0282369", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q555Z2", "DDB_G0274797", "P14794", "DDB_G0280755" ] }, "reaction_10709588": { "compartment": "compartment_7660", "id": "reaction_10709588", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673970", "species_10709573" ], "products": [ "species_10709586" ], "modifiers": [], "additional_components": [ "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X77", "DDB_G0279151", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54IY3", "DDB_G0288427", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54WU9", "DDB_G0279421", "Q54HY5", "DDB_G0289141", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54XI2", "DDB_G0278741", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q55GU8", "DDB_G0267468", "P0CG77", "DDB_G0286907", "Q54X55", "DDB_G0279195", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54HY5", "DDB_G0289141", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q54TK0", "DDB_G0281703", "Q869L7", "DDB_G0279421", "Q55F19", "DDB_G0268668", "P0CG88", "DDB_G0269458", "Q54X77", "DDB_G0279151", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "P0CG80", "DDB_G0291928", "Q86KZ2", "DDB_G0272362", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54IY3", "DDB_G0288427", "Q54WU9", "DDB_G0279421", "P14794", "DDB_G0280755", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357" ] }, "reaction_10676022": { "compartment": "compartment_7660", "id": "reaction_10676022", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674078", "species_10674091" ], "products": [ "species_10674093" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q1ZXF2", "DDB_G0284713", "Q54QM4", "DDB_G0283857" ] }, "reaction_10710849": { "compartment": "compartment_7660", "id": "reaction_10710849", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10710844" ], "products": [ "species_10710846", "species_113541" ], "modifiers": [ [ "species_10710844", "catalyst" ] ], "additional_components": [ "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54KS3", "DDB_G0287149", "Q54TN8", "DDB_G0281641", "Q54TY2", "DDB_G0281441", "Q54FA8", "DDB_G0291037", "B0M0P5", "DDB_G0286013", "P54685", "DDB_G0285417", "Q54X62", "DDB_G0279177", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q7KWK5", "DDB_G0276803", "B0G131", "DDB_G0294609", "Q55FP1", "DDB_G0268014", "Q54N41", "DDB_G0285521", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "P0CG88", "DDB_G0269458", "Q54MD4", "DDB_G0286027", "Q54BN3", "DDB_G0293702", "Q54I13", "DDB_G0289079", "Q54CS2", "DDB_G0292794", "Q869U4", "DDB_G0276443", "Q54Y85", "DDB_G0278367", "P0CG79", "DDB_G0282369", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q551N8", "DDB_G0276481", "Q54RD4", "DDB_G0283189", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q54YG9", "DDB_G0278241", "Q54N97", "DDB_G0285381", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "O00835", "DDB_G0278729", "Q54R66", "DDB_G0283365", "Q54E21", "DDB_G0291868", "P0CG77", "DDB_G0286907", "Q54J75", "DDB_G0288257", "Q54TK0", "DDB_G0281703", "Q54Z08", "DDB_G0277977", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54K47", "DDB_G0287607", "Q75JQ9", "DDB_G0272222", "P0CG80", "DDB_G0291928", "Q54ST4", "DDB_G0282235", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q7KWN0", "DDB_G0272740", "Q555Z2", "DDB_G0274797", "Q54MH9", "DDB_G0285961", "P14794", "DDB_G0280755" ] }, "reaction_10682781": { "compartment": "compartment_70101", "id": "reaction_10682781", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29368", "species_29356" ], "products": [ "species_29408", "species_29382", "species_5279533" ], "modifiers": [ [ "species_10676809", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10681988": { "compartment": "compartment_70101", "id": "reaction_10681988", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10681985" ], "products": [ "species_10681963" ], "modifiers": [ [ "species_10681985", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "species_113552", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q54W37", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q6TMJ9", "DDB_G0280061", "Q54UX4", "DDB_G0280761", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043" ] }, "reaction_10687261": { "compartment": "compartment_5460", "id": "reaction_10687261", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_916850" ], "products": [ "species_113552", "species_880046" ], "modifiers": [ [ "species_10687258", "catalyst" ] ], "additional_components": [ "CHEBI:33739", "Q55FI1", "DDB_G0268104" ] }, "reaction_10724738": { "compartment": "compartment_876", "id": "reaction_10724738", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10682758" ], "products": [ "species_10682761" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "LigandDisplayForward?ligandId=6687", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=8994", "LigandDisplayForward?ligandId=8993", "Q54N21", "DDB_G0291344", "P21837", "DDB_G0285419", "LigandDisplayForward?ligandId=6602", "LigandDisplayForward?ligandId=6599", "Q54WD8", "DDB_G0291344", "P18142", "DDB_G0283085", "LigandDisplayForward?ligandId=6687", "Q86L18", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "LigandDisplayForward?ligandId=6598", "LigandDisplayForward?ligandId=6693", "LigandDisplayForward?ligandId=7597", "LigandDisplayForward?ligandId=9073", "LigandDisplayForward?ligandId=9074" ] }, "reaction_10724723": { "compartment": "compartment_70101", "id": "reaction_10724723", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10724720", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10725941": { "compartment": "compartment_70101", "id": "reaction_10725941", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10725938", "catalyst" ] ], "additional_components": [ "DDB_G0284331" ] }, "reaction_10684216": { "compartment": "compartment_876", "id": "reaction_10684216", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684051" ], "products": [ "species_10684213" ], "modifiers": [ [ "species_10684051", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438" ] }, "reaction_10712040": { "compartment": "compartment_876", "id": "reaction_10712040", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_417891", "species_109276" ], "products": [ "species_6797635", "species_109277" ], "modifiers": [ [ "species_10712037", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10683869": { "compartment": "compartment_876", "id": "reaction_10683869", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676221", "species_10683865" ], "products": [ "species_10683867" ], "modifiers": [], "additional_components": [ "Q03100", "DDB_G0281545", "species_29926", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "Q03100", "DDB_G0281545", "P34044", "DDB_G0283151", "species_29438", "species_29926" ] }, "reaction_10725991": { "compartment": "compartment_70101", "id": "reaction_10725991", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10676262", "catalyst" ] ], "additional_components": [ "DDB_G0289121" ] }, "reaction_10722710": { "compartment": "compartment_876", "id": "reaction_10722710", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722706", "species_10683865" ], "products": [ "species_10722708" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_29438", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10684207": { "compartment": "compartment_70101", "id": "reaction_10684207", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_29356" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10684204", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "B0G0Y8", "DDB_G0268634" ] }, "reaction_10683912": { "compartment": "compartment_70101", "id": "reaction_10683912", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_179838" ], "modifiers": [ [ "species_10683909", "catalyst" ] ], "additional_components": [ "P54673", "DDB_G0278727", "P54675", "DDB_G0275011", "Q54DK0", "DDB_G0292252", "Q54S78", "DDB_G0282625", "P36408", "DDB_G0277143", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625" ] }, "reaction_10724275": { "compartment": "compartment_70101", "id": "reaction_10724275", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10680825", "species_10683777" ], "products": [ "species_10724273" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10722760": { "compartment": "compartment_876", "id": "reaction_10722760", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722758" ], "products": [ "species_10722706", "species_10686923" ], "modifiers": [], "additional_components": [ "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "species_111349" ] }, "reaction_10722770": { "compartment": "compartment_876", "id": "reaction_10722770", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722708" ], "products": [ "species_10722758", "species_29372" ], "modifiers": [ [ "species_10722708", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438", "species_29420", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "Q54LD1", "DDB_G0286817", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q556I3", "DDB_G0286817", "species_29438" ] }, "reaction_10698635": { "compartment": "compartment_70101", "id": "reaction_10698635", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10698631" ], "products": [ "species_10698633" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "species_874088", "Q54BN2", "DDB_G0293546" ] }, "reaction_10723428": { "compartment": "compartment_70101", "id": "reaction_10723428", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698604", "species_8982080" ], "products": [ "species_10723426" ], "modifiers": [], "additional_components": [ "DDB_G0287361", "CHEBI:49537", "CHEBI:47037", "CHEBI:49537", "CHEBI:47037", "Q54KG1", "DDB_G0287361" ] }, "reaction_10682899": { "compartment": "compartment_70101", "id": "reaction_10682899", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682888", "species_10682859" ], "products": [ "species_10682853", "species_10682894", "species_10682859" ], "modifiers": [ [ "species_10682896", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q55GN5", "DDB_G0267590", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10702014": { "compartment": "compartment_263163", "id": "reaction_10702014", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10702010" ], "products": [ "species_10702012" ], "modifiers": [], "additional_components": [ "B0G185", "DDB_G0295711", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031", "B0G185", "DDB_G0295711", "species_1806205", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q54WW3", "DDB_G0279359", "Q54HS9", "DDB_G0289247", "Q8I8U2", "DDB_G0281957", "Q54YX3", "DDB_G0278031" ] }, "reaction_10682916": { "compartment": "compartment_876", "id": "reaction_10682916", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682905", "species_10682853", "species_10682859" ], "products": [ "species_10682911", "species_10682853", "species_10682859" ], "modifiers": [ [ "species_10682913", "catalyst" ] ], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55GN5", "DDB_G0267590" ] }, "reaction_10682453": { "compartment": "compartment_70101", "id": "reaction_10682453", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682429", "species_29438" ], "products": [ "species_10682433", "species_29420" ], "modifiers": [ [ "species_10682450", "catalyst" ] ], "additional_components": [ "species_29420", "O00909", "DDB_G0289173", "O00909", "DDB_G0289173", "species_29438", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10682882": { "compartment": "compartment_70101", "id": "reaction_10682882", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10682853", "species_10682871", "species_10682859" ], "products": [ "species_10682853", "species_10682859", "species_10682877" ], "modifiers": [ [ "species_10682879", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54NW7", "DDB_G0284951", "Q54HM5", "DDB_G0289379", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55DR2", "DDB_G0289379", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951" ] }, "reaction_10701766": { "compartment": "compartment_171907", "id": "reaction_10701766", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701749" ], "products": [ "species_10701763" ], "modifiers": [ [ "species_10701749", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10679542": { "compartment": "compartment_984", "id": "reaction_10679542", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679281": { "compartment": "compartment_984", "id": "reaction_10679281", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_70115", "species_189049" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10722325": { "compartment": "compartment_7660", "id": "reaction_10722325", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953383", "species_8953399" ], "modifiers": [ [ "species_10722322", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10679278": { "compartment": "compartment_984", "id": "reaction_10679278", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189108", "species_109276" ], "products": [ "species_70115", "species_191103", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679538": { "compartment": "compartment_984", "id": "reaction_10679538", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191103", "species_109276" ], "products": [ "species_70115", "species_188986" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679540": { "compartment": "compartment_984", "id": "reaction_10679540", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10703366": { "compartment": "compartment_984", "id": "reaction_10703366", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679275", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10679288": { "compartment": "compartment_984", "id": "reaction_10679288", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188986", "species_109276" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679285", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10695627": { "compartment": "compartment_876", "id": "reaction_10695627", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10695624", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949", "Q54UK0", "DDB_G0281031", "Q54Q49", "DDB_G0284155", "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "Q54WR4", "DDB_G0279483" ] }, "reaction_10695602": { "compartment": "compartment_876", "id": "reaction_10695602", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602448", "species_29356" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10695599", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q54PR7", "DDB_G0284367" ] }, "reaction_10718995": { "compartment": "compartment_876", "id": "reaction_10718995", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10692772", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q86A02", "DDB_G0275635", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190" ] }, "reaction_10718847": { "compartment": "compartment_876", "id": "reaction_10718847", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718843", "species_10718837" ], "products": [ "species_10718845" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10720418": { "compartment": "compartment_876", "id": "reaction_10720418", "reactome": "R-DDI-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_179856" ], "products": [ "species_10718325" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718711": { "compartment": "compartment_70101", "id": "reaction_10718711", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718707", "species_10718699" ], "products": [ "species_10718709" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10718568": { "compartment": "compartment_70101", "id": "reaction_10718568", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718564", "species_10718544", "species_10718532" ], "products": [ "species_10718566" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10718522": { "compartment": "compartment_876", "id": "reaction_10718522", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718315", "species_10681832", "species_10718335", "species_10718319", "species_10718325", "species_10718317" ], "products": [ "species_10718337" ], "modifiers": [], "additional_components": [ "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q55AN3", "DDB_G0274695", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "DDB_G0287325", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "DDB_G0287325", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718577": { "compartment": "compartment_70101", "id": "reaction_10718577", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709499", "species_10718570" ], "products": [ "species_10718532" ], "modifiers": [], "additional_components": [ "DDB_G0278711", "DDB_G0277139", "DDB_G0277139" ] }, "reaction_10718347": { "compartment": "compartment_876", "id": "reaction_10718347", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10684438", "species_10718337", "species_10718343", "species_10718275" ], "products": [ "species_10718345" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "Q75JD4", "DDB_G0274695", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "species_179856", "Q54H39", "DDB_G0289721", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10719091": { "compartment": "compartment_24339", "id": "reaction_10719091", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10719089", "species_10719055" ], "products": [ "species_10719087" ], "modifiers": [], "additional_components": [ "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102", "species_113592", "P36415", "DDB_G0269144", "Q54HE7", "DDB_G0289511", "Q55CB2", "DDB_G0290593", "Q54HE9", "DDB_G0289533", "Q86HW6", "DDB_G0280111", "O96623", "DDB_G0282813", "Q554S6", "DDB_G0274131", "Q8MN58", "DDB_G0277403", "O96622", "DDB_G0277825", "Q54U74", "DDB_G0281235", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54GB3", "DDB_G0290363", "Q54NT2", "DDB_G0284997", "Q54Y50", "DDB_G0278685", "Q55EU6", "DDB_G0268744", "O96626", "DDB_G0288319", "Q55DY5", "DDB_G0287981", "Q8I7P3", "DDB_G0267462", "Q94464", "DDB_G0277849", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54JL1", "DDB_G0287981", "O96621", "DDB_G0272106", "Q75JD4", "DDB_G0274695", "Q54HF0", "DDB_G0289507", "Q54UC8", "DDB_G0281155", "Q9U1M9", "DDB_G0277851", "Q55CB3", "DDB_G0290593", "Q86KI1", "DDB_G0273439", "Q54GX7", "DDB_G0289811", "P07830", "DDB_G0269234", "P36415", "DDB_G0269144", "species_29420", "O96624", "DDB_G0292804", "Q553U6", "DDB_G0275023", "Q54X82", "DDB_G0279141", "Q1ZXE9", "DDB_G0285703", "Q8T867", "DDB_G0276447", "P07829", "DDB_G0289487", "Q54H39", "DDB_G0289721", "Q55DS6", "DDB_G0287981", "Q557J6", "DDB_G0273447", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q54HF1", "DDB_G0289505", "Q54D97", "DDB_G0292392", "P42528", "DDB_G0283755", "Q9BKJ9", "DDB_G0287035", "Q55CU2", "DDB_G0269902", "Q54VV7", "DDB_G0280111", "species_113592", "P25870", "DDB_G0277221", "Q6TMJ9", "DDB_G0280061", "P07828", "DDB_G0289489", "Q54FU0", "DDB_G0290593", "O96625", "DDB_G0269102" ] }, "reaction_10718357": { "compartment": "compartment_876", "id": "reaction_10718357", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718345", "species_113592" ], "products": [ "species_29370", "species_10718354" ], "modifiers": [ [ "species_10718345", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274695", "Q54U74", "DDB_G0281235", "Q54VV7", "DDB_G0280111", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718998": { "compartment": "compartment_876", "id": "reaction_10718998", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10718914", "catalyst" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "Q86HW6", "DDB_G0280111", "P54672", "DDB_G0277139", "Q55AN3", "DDB_G0274695", "Q54KI4", "DDB_G0287325", "Q54S78", "DDB_G0282625", "Q555L8", "DDB_G0274695", "Q54GD0", "DDB_G0290233", "P54673", "DDB_G0278727", "Q75JD4", "DDB_G0274695", "P54675", "DDB_G0275011", "Q54U74", "DDB_G0281235", "Q9BKJ9", "DDB_G0287035", "Q54VV7", "DDB_G0280111", "Q54GB3", "DDB_G0290363", "P25870", "DDB_G0277221", "Q54Y50", "DDB_G0278685", "Q54X82", "DDB_G0279141", "Q6TMJ9", "DDB_G0280061", "Q54UC8", "DDB_G0281155", "P54674", "DDB_G0283081", "Q55FX5", "DDB_G0282625", "species_179856", "Q54H39", "DDB_G0289721" ] }, "reaction_10718721": { "compartment": "compartment_876", "id": "reaction_10718721", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_10718715" ], "products": [ "species_10718717" ], "modifiers": [ [ "species_10718719", "inhibitor" ] ], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q9BKJ9", "DDB_G0287035", "Q54UC8", "DDB_G0281155", "Q9BKJ9", "DDB_G0287035", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54UC8", "DDB_G0281155", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10718575": { "compartment": "compartment_70101", "id": "reaction_10718575", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718566" ], "products": [ "species_10718564", "species_10718544", "species_10709499", "species_10718570" ], "modifiers": [ [ "species_10718566", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180", "Q55FE2", "DDB_G0268156", "DDB_G0278711", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q54B82", "DDB_G0293844", "Q54E53", "DDB_G0291848", "Q75K24", "DDB_G0275471", "P54672", "DDB_G0277139", "Q55BD5", "DDB_G0271282", "Q54C92", "DDB_G0293180" ] }, "reaction_10725842": { "compartment": "compartment_70101", "id": "reaction_10725842", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718263", "species_9648300" ], "products": [ "species_10718719" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "species_9648300", "Q54H39", "DDB_G0289721" ] }, "reaction_10698195": { "compartment": "compartment_70101", "id": "reaction_10698195", "reactome": "R-DDI-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698192", "catalyst" ] ], "additional_components": [ "DDB_G0290313" ] }, "reaction_10698213": { "compartment": "compartment_70101", "id": "reaction_10698213", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_29372" ], "products": [ "species_2892454", "species_113551" ], "modifiers": [ [ "species_10698210", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10698117": { "compartment": "compartment_70101", "id": "reaction_10698117", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698114", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698178": { "compartment": "compartment_70101", "id": "reaction_10698178", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698175", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10698125": { "compartment": "compartment_70101", "id": "reaction_10698125", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_352022", "species_74722" ], "modifiers": [ [ "species_10698122", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10698190": { "compartment": "compartment_70101", "id": "reaction_10698190", "reactome": "R-DDI-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698187", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54G87", "DDB_G0290313" ] }, "reaction_10698982": { "compartment": "compartment_70101", "id": "reaction_10698982", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10698913", "catalyst" ], [ "species_10698980", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10725463": { "compartment": "compartment_70101", "id": "reaction_10725463", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10698070", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626" ] }, "reaction_10698204": { "compartment": "compartment_70101", "id": "reaction_10698204", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10698201", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10685792": { "compartment": "compartment_876", "id": "reaction_10685792", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685018": { "compartment": "compartment_876", "id": "reaction_10685018", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429130", "species_351626" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10685015", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10685539": { "compartment": "compartment_876", "id": "reaction_10685539", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10685536", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10685554": { "compartment": "compartment_876", "id": "reaction_10685554", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685551", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685476": { "compartment": "compartment_876", "id": "reaction_10685476", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10685473", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10685794": { "compartment": "compartment_876", "id": "reaction_10685794", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10722613": { "compartment": "compartment_70101", "id": "reaction_10722613", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10722610", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10685568": { "compartment": "compartment_876", "id": "reaction_10685568", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10685565", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10685434": { "compartment": "compartment_876", "id": "reaction_10685434", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10685431", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10685563": { "compartment": "compartment_876", "id": "reaction_10685563", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10685560", "catalyst" ] ], "additional_components": [ "Q9NIV0", "DDB_G0283389", "Q8I0L6", "DDB_G0280059" ] }, "reaction_10685429": { "compartment": "compartment_172574", "id": "reaction_10685429", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_1470067", "species_445832" ], "modifiers": [ [ "species_10685426", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_29418", "species_29426", "species_71067", "species_29418", "DDB_G0276973" ] }, "reaction_10685421": { "compartment": "compartment_876", "id": "reaction_10685421", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_446589", "species_351626" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10685418", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:16737", "LigandDisplayForward?ligandId=1231", "CHEBI:641", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10687849": { "compartment": "compartment_70101", "id": "reaction_10687849", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"DDB_G0277907", "Q54MZ5", "DDB_G0285597", "Q55BE6", "DDB_G0271298", "Q54UU3", "DDB_G0280823", "Q55E21", "DDB_G0270866", "Q55AB5", "DDB_G0271976", "Q86K01", "DDB_G0272893", "Q54G90", "DDB_G0290307", "Q55BS9", "DDB_G0270380", "species_29420", "Q55D61", "DDB_G0269192", "Q54J23", "DDB_G0288349", "P11874", "DDB_G0276441", "Q54PX9", "DDB_G0284237", "Q55GJ7", "DDB_G0268302", "Q55BY1", "DDB_G0270316", "Q54BN4", "DDB_G0293700", "Q54X51", "DDB_G0279207", "Q54VN6", "DDB_G0280229", "Q54G86", "DDB_G0290315", "Q54NG2", "DDB_G0285277", "Q54E20", "DDB_G0291870", "P0CG80", "DDB_G0291928", "P14794", "DDB_G0280755", "Q869U7", "DDB_G0276415", "Q54XB5", "DDB_G0279061", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54QM8", "DDB_G0283741", "Q9BMX0", "DDB_G0288613", "Q55A46", "DDB_G0272108", "Q54Z69", "DDB_G0277803", "Q54XI5", "DDB_G0278959", "P14132", "DDB_G0289877", "Q54PH8", "DDB_G0284533", "Q55AQ9", "DDB_G0271668", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54ME8", "DDB_G0286007", "Q54J50", "DDB_G0288295", "Q7YZN9", "DDB_G0277919", "Q54MA6", "DDB_G0286075", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54D63", "DDB_G0292460", "Q54JE3", "DDB_G0288101", "Q75JP6", "DDB_G0272470", "Q54TL8", "DDB_G0281677", "P27685", "DDB_G0293742", "Q54KR9", "DDB_G0287197", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "Q54E24", "DDB_G0291864", "Q54S90", "DDB_G0282601", "P22685", "DDB_G0286501", "Q54I89", "DDB_G0288923", "Q54VZ4", "DDB_G0279997", "Q54ZW5", "DDB_G0277345", "Q55BN7", "DDB_G0270424", "Q54DH9", "DDB_G0292240", "P0CG78", "DDB_G0289449", "P14797", "DDB_G0276765", "Q55A19", "DDB_G0272250", "P46793", "DDB_G0276457", "Q55D17", "DDB_G0269814", "Q54Y41", "DDB_G0278429", "P0CG77", "DDB_G0286907", "Q54Q51", "DDB_G0284093", "Q54XX3", "DDB_G0278539", "Q54X53", "DDB_G0279387", "Q54TK0", "DDB_G0281703", "C7G051", "DDB_G0302511", "Q54BQ3", "DDB_G0293502", "O77082", "DDB_G0286117", "Q54J69", "DDB_G0288273", "Q54GK6", "DDB_G0290091", "P16168", "DDB_G0279189", "P34113", "DDB_G0291862", "Q1ZXC2", "DDB_G0290745", "P22683", "DDB_G0283393", "P13023", "DDB_G0274113", "P48160", "DDB_G0292388", "P42520", "DDB_G0290141", "Q54I41", "DDB_G0289025", "Q55CW5", "DDB_G0270984" ] }, "reaction_10675713": { "compartment": "compartment_7660", "id": "reaction_10675713", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675707", "species_10675016" ], "products": [ "species_10675711" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405" ] }, "reaction_10675717": { "compartment": "compartment_7660", "id": "reaction_10675717", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675113", "species_10675711" ], "products": [ "species_10675715" ], "modifiers": [], "additional_components": [ "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54IM0", "DDB_G0288665", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q8T1F9", "DDB_G0275127", "Q54R53", "DDB_G0283405", "Q54GS8", "DDB_G0289935", "Q86JI9", "DDB_G0271514", "Q54YW8", "DDB_G0278039", "Q54EH2", "DDB_G0291636", "Q86AQ5", "DDB_G0277199", "Q54WL4", "DDB_G0279565", "Q54IM0", "DDB_G0288665", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q557J3", "DDB_G0273425", "Q55AB6", "DDB_G0272036", "Q86JM3", "DDB_G0272022", "Q54FA8", "DDB_G0291037", "Q55FJ5", "DDB_G0268080", "Q8T1V7", "DDB_G0277671", "Q54R66", "DDB_G0283365", "Q54FU1", "DDB_G0290591", "Q54LP2", "DDB_G0286521", "Q54IZ9", "DDB_G0288449", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54K02", "DDB_G0287707", "Q54R53", "DDB_G0283405", "Q54SN4", "DDB_G0282339" ] }, "reaction_10675709": { "compartment": "compartment_7660", "id": "reaction_10675709", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83747", "species_10675045" ], "products": [ "species_10675707" ], "modifiers": [], "additional_components": [ "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54FU1", "DDB_G0290591", "Q54YB5", "DDB_G0278321", "Q8T1F9", "DDB_G0275127" ] }, "reaction_10679857": { "compartment": "compartment_13231", "id": "reaction_10679857", "reactome": "R-DDI-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677717" ], "products": [ "species_10679855" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10681841": { "compartment": "compartment_70101", "id": "reaction_10681841", "reactome": "R-DDI-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677669" ], "products": [ "species_29370", "species_10677717" ], "modifiers": [ [ "species_10681384", "catalyst" ] ], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10681837": { "compartment": "compartment_70101", "id": "reaction_10681837", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10681382" ], "products": [ "species_10681384", "species_29420" ], "modifiers": [ [ "species_10681834", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_111349", "P34144", "DDB_G0277869", "species_29438", "Q54F64", "DDB_G0291085", "Q54NG0", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q86G47", "DDB_G0289665", "Q553D3", "DDB_G0275679", "Q8IS14", "DDB_G0277913", "Q54G10", "DDB_G0293396", "Q54C56", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q550V3", "DDB_G0277017", "Q8IS18", "DDB_G0269252", "Q1ZXN6", "DDB_G0272372", "Q54GP2", "DDB_G0293396", "Q55G27", "DDB_G0293396", "Q54UJ2", "DDB_G0293396", "Q8ST25", "DDB_G0272032", "Q1ZXH8", "DDB_G0279733", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q86HN1", "DDB_G0293396", "Q8IS12", "DDB_G0275703", "Q54J11", "DDB_G0288383", "Q54BV5", "DDB_G0293396", "Q54MM3", "DDB_G0285859", "Q54S15", "DDB_G0293396", "Q54PK2", "DDB_G0291085", "Q54DW4", "DDB_G0291978", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q54XA7", "DDB_G0293396", "Q54B37", "DDB_G0293978", "Q8IS16", "DDB_G0276963", "Q55G61", "DDB_G0268354", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q1ZX99", "DDB_G0293928", "Q55FD8", "DDB_G0268578", "Q54VX2", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54P81", "DDB_G0293396", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q54SG9", "DDB_G0282475", "Q8IS21", "DDB_G0269222", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54PQ4", "DDB_G0284329", "Q54KI4", "DDB_G0287325", "Q54H95", "DDB_G0289613", "Q54T65", "DDB_G0293396", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q55DL8", "DDB_G0293396", "Q54F88", "DDB_G0293396" ] }, "reaction_10704220": { "compartment": "compartment_876", "id": "reaction_10704220", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704091", "species_10678454" ], "products": [ "species_10704218" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704343": { "compartment": "compartment_876", "id": "reaction_10704343", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704339", "species_10704334" ], "products": [ "species_10704341" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q54QK0", "DDB_G0283803", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10704230": { "compartment": "compartment_876", "id": "reaction_10704230", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10704218" ], "products": [ "species_10704227" ], "modifiers": [ [ "species_10704218", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q55C68", "DDB_G0270200", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703817": { "compartment": "compartment_876", "id": "reaction_10703817", "reactome": "R-DDI-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703808", "species_10678454" ], "products": [ "species_10703810" ], "modifiers": [ [ "species_10703815", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0290123" ] }, "reaction_10725190": { "compartment": "compartment_70101", "id": "reaction_10725190", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725136", "species_2530486" ], "products": [ "species_10725178", "species_111294" ], "modifiers": [ [ "species_10725185", "catalyst" ], [ "species_10725188", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10704105": { "compartment": "compartment_876", "id": "reaction_10704105", "reactome": "R-DDI-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703810", "species_10704084" ], "products": [ "species_10704086" ], "modifiers": [ [ "species_10704103", "catalyst" ], [ "species_10704093", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q75JK0", "DDB_G0276025", "Q54HC6", "DDB_G0289555", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q54XX5", "DDB_G0278535", "Q55FV4", "DDB_G0267934", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10725346": { "compartment": "compartment_876", "id": "reaction_10725346", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678450", "species_10676232" ], "products": [ "species_10725344" ], "modifiers": [ [ "species_10725342", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "species_74016", "Q7Z2B8", "DDB_G0277917", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725393": { "compartment": "compartment_876", "id": "reaction_10725393", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725344" ], "products": [ "species_10725391" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "species_74016", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q7Z2B8", "DDB_G0277917", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P02599", "DDB_G0279407", "O00897", "DDB_G0269104", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "species_74016", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "Q7Z2B8", "DDB_G0277917", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703913": { "compartment": "compartment_70101", "id": "reaction_10703913", "reactome": "R-DDI-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703911" ], "products": [ "species_10674713", "species_10703909" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703705": { "compartment": "compartment_70101", "id": "reaction_10703705", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_113592" ], "products": [ "species_29370", "species_10703702" ], "modifiers": [ [ "species_10703686", "catalyst" ] ], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10704378": { "compartment": "compartment_876", "id": "reaction_10704378", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10704334" ], "products": [ "species_10704355", "species_29372" ], "modifiers": [ [ "species_10704375", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "DDB_G0283157" ] }, "reaction_10725283": { "compartment": "compartment_70101", "id": "reaction_10725283", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725185", "species_9653479" ], "products": [ "species_10725188" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "LigandDisplayForward?ligandId=8030", "LigandDisplayForward?ligandId=6531", "LigandDisplayForward?ligandId=8025", "LigandDisplayForward?ligandId=8024", "pubchem.compound:216453", "LigandDisplayForward?ligandId=8028", "LigandDisplayForward?ligandId=8026", "Q54RT9", "DDB_G0283053", "LigandDisplayForward?ligandId=8030", "Q55D51", "DDB_G0270948" ] }, "reaction_10703885": { "compartment": "compartment_70101", "id": "reaction_10703885", "reactome": "R-DDI-5672957", "name": "PP2A dephosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703868", "species_29356" ], "products": [ "species_10703882", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10703358": { "compartment": "compartment_70101", "id": "reaction_10703358", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10703324" ], "products": [ "species_10703353" ], "modifiers": [ [ "species_10703355", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10725301": { "compartment": "compartment_876", "id": "reaction_10725301", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725255", "species_29356" ], "products": [ "species_10678450", "species_8848337" ], "modifiers": [ [ "species_10725294", "catalyst" ], [ "species_10725296", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10725093": { "compartment": "compartment_12045", "id": "reaction_10725093", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725069", "species_71284" ], "products": [ "species_10725089", "species_71285" ], "modifiers": [ [ "species_10711228", "catalyst" ], [ "species_10725091", "inhibitor" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "species_29426", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "pubchem.compound:6918831" ] }, "reaction_10725304": { "compartment": "compartment_12045", "id": "reaction_10725304", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089" ], "products": [ "species_10678450" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703887": { "compartment": "compartment_70101", "id": "reaction_10703887", "reactome": "R-DDI-5672958", "name": "YWHAB dimer dissociates from KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703882" ], "products": [ "species_10703880", "species_10674713" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138" ] }, "reaction_10725460": { "compartment": "compartment_876", "id": "reaction_10725460", "reactome": "R-DDI-9658445", "name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10725457", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "O15757", "DDB_G0275619", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54HA8", "DDB_G0289585", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10704222": { "compartment": "compartment_70101", "id": "reaction_10704222", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703686", "species_10704091" ], "products": [ "species_10704093" ], "modifiers": [], "additional_components": [ "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "DDB_G0270200", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q55C68", "DDB_G0270200", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703915": { "compartment": "compartment_70101", "id": "reaction_10703915", "reactome": "R-DDI-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703864", "species_29356" ], "products": [ "species_29372", "species_10703911" ], "modifiers": [ [ "species_10683554", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469" ] }, "reaction_10704272": { "compartment": "compartment_20699", "id": "reaction_10704272", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10704268" ], "products": [ "species_10704270" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54B86", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54HC6", "DDB_G0289555", "Q54B86", "DDB_G0293838", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54XX5", "DDB_G0278535", "Q54CB4", "DDB_G0293838" ] }, "reaction_10725637": { "compartment": "compartment_876", "id": "reaction_10725637", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725633", "species_10725631" ], "products": [ "species_10725635" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "species_29438", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666", "Q54U62", "DDB_G0281253", "Q8SSQ3", "DDB_G0274607", "P32252", "DDB_G0292998", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q1ZXQ0", "DDB_G0270932", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q75J93", "DDB_G0277381", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "P32253", "DDB_G0281385", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54VD5", "DDB_G0280437", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "species_29438", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "P32254", "DDB_G0283537", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725306": { "compartment": "compartment_876", "id": "reaction_10725306", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678452", "species_29420" ], "products": [ "species_10679153" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10703364": { "compartment": "compartment_876", "id": "reaction_10703364", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703308", "species_10703322" ], "products": [ "species_10703324" ], "modifiers": [], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10725369": { "compartment": "compartment_17906", "id": "reaction_10725369", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725342" ], "products": [ "species_10725367" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725313": { "compartment": "compartment_876", "id": "reaction_10725313", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10704086" ], "products": [ "species_10704209" ], "modifiers": [], "additional_components": [ "LigandDisplayForward?ligandId=8943", "LigandDisplayForward?ligandId=10387", "LigandDisplayForward?ligandId=9977", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "LigandDisplayForward?ligandId=8943", "P32252", "DDB_G0292998", "Q54VU4", "DDB_G0280133", "Q86HG9", "DDB_G0278535", "Q1ZXQ0", "DDB_G0270932", "Q54VD5", "DDB_G0280437", "species_29438", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q75J93", "DDB_G0277381", "Q55FV4", "DDB_G0267934", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=10387", "P32254", "DDB_G0283537", "LigandDisplayForward?ligandId=9977", "Q54TM7", "DDB_G0281557", "P32253", "DDB_G0281385", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385" ] }, "reaction_10725257": { "compartment": "compartment_876", "id": "reaction_10725257", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725253" ], "products": [ "species_10725255" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725298": { "compartment": "compartment_876", "id": "reaction_10725298", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10725294" ], "products": [ "species_10725296" ], "modifiers": [], "additional_components": [ "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "species_9647934", "Q54F01", "DDB_G0291205" ] }, "reaction_10704082": { "compartment": "compartment_876", "id": "reaction_10704082", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [ [ "species_10704079", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q8SSQ3", "DDB_G0274607", "Q54FF3", "DDB_G0290901", "Q8IS15", "DDB_G0277915", "Q86G47", "DDB_G0289665", "Q8IS16", "DDB_G0276963", "Q8IS14", "DDB_G0277913", "Q54L90", "DDB_G0286773", "Q8IS20", "DDB_G0282381", "Q8IS19", "DDB_G0289667", "species_6797635", "Q8IS18", "DDB_G0269252", "Q55FD8", "DDB_G0268578", "Q8SSQ0", "DDB_G0274605", "Q54XL4", "DDB_G0289613", "Q54TK8", "DDB_G0281573", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q552M5", "DDB_G0276019", "Q54PQ4", "DDB_G0284329", "Q8SSW7", "DDB_G0271868", "Q54WL2", "DDB_G0289613", "Q54H95", "DDB_G0289613", "Q8IS12", "DDB_G0275703", "Q8IS11", "DDB_G0290267", "Q55GH9", "DDB_G0267666" ] }, "reaction_10725281": { "compartment": "compartment_20699", "id": "reaction_10725281", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725089", "species_200993" ], "products": [ "species_76194", "species_10725253" ], "modifiers": [ [ "species_10725278", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54PF0", "DDB_G0284603", "Q557H5", "DDB_G0284603", "Q550I3", "DDB_G0277093", "Q550R7", "DDB_G0284603" ] }, "reaction_10703362": { "compartment": "compartment_876", "id": "reaction_10703362", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703326", "species_10678454" ], "products": [ "species_10703328" ], "modifiers": [], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10704369": { "compartment": "compartment_876", "id": "reaction_10704369", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10704355", "species_29356" ], "products": [ "species_10704367", "species_29372" ], "modifiers": [ [ "species_10683554", "catalyst" ], [ "species_10704306", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q54U62", "DDB_G0281253", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q86HG9", "DDB_G0278535", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q552C6", "DDB_G0276187", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54TM7", "DDB_G0281557", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P18160", "DDB_G0283385", "Q9XZE5", "DDB_G0290263", "Q54QR9", "DDB_G0283601", "Q54VB6", "DDB_G0280469", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703360": { "compartment": "compartment_70101", "id": "reaction_10703360", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703353" ], "products": [ "species_10703308" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10703870": { "compartment": "compartment_70101", "id": "reaction_10703870", "reactome": "R-DDI-5672954", "name": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674713", "species_10703702" ], "products": [ "species_10703868" ], "modifiers": [], "additional_components": [ "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934", "P54632", "DDB_G0269138", "Q75JK0", "DDB_G0276025", "Q54DF2", "DDB_G0292304", "Q54VU4", "DDB_G0280133", "Q552C6", "DDB_G0276187", "P18160", "DDB_G0283385", "Q55FV4", "DDB_G0267934" ] }, "reaction_10703866": { "compartment": "compartment_70101", "id": "reaction_10703866", "reactome": "R-DDI-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703862", "species_10674713" ], "products": [ "species_10703864" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535" ] }, "reaction_10703331": { "compartment": "compartment_876", "id": "reaction_10703331", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10703328" ], "products": [ "species_10703326", "species_10679153" ], "modifiers": [ [ "species_10703328", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996", "Q8SSU4", "DDB_G0274211", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0284177", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "Q8SSU4", "DDB_G0274211", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "Q54RT3", "DDB_G0284177", "Q54VD5", "DDB_G0280437", "species_29438", "Q75J93", "DDB_G0277381", "Q54WD0", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q86JJ7", "DDB_G0284177", "Q54Y08", "DDB_G0278483", "P15064", "DDB_G0293434", "Q5TJ65", "DDB_G0289541", "Q55AR6", "DDB_G0271750", "P03967", "DDB_G0292996" ] }, "reaction_10725311": { "compartment": "compartment_876", "id": "reaction_10725311", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10678454" ], "products": [ "species_10679153" ], "modifiers": [ [ "species_10678454", "catalyst" ] ], "additional_components": [ "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10725308": { "compartment": "compartment_876", "id": "reaction_10725308", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10679153" ], "products": [ "species_10678454", "species_29420" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "species_29420", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "Q54U62", "DDB_G0281253", "P32254", "DDB_G0283537", "P32252", "DDB_G0292998", "Q1ZXQ0", "DDB_G0270932", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "P15064", "DDB_G0293434", "species_29438", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381" ] }, "reaction_10676462": { "compartment": "compartment_7660", "id": "reaction_10676462", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676308", "species_10676297" ], "products": [ "species_10676310" ], "modifiers": [], "additional_components": [ "Q54LJ0", "DDB_G0286617", "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10676470": { "compartment": "compartment_7660", "id": "reaction_10676470", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676446" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676448": { "compartment": "compartment_7660", "id": "reaction_10676448", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676446" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676452": { "compartment": "compartment_7660", "id": "reaction_10676452", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676450" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674872": { "compartment": "compartment_7660", "id": "reaction_10674872", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674862" ], "products": [ "species_10674870" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54J75", "DDB_G0288257", "Q55FP1", "DDB_G0268014", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54CN8", "DDB_G0292838", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q555L9", "DDB_G0274697", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338" ] }, "reaction_10674197": { "compartment": "compartment_7660", "id": "reaction_10674197", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674195" ], "products": [ "species_10674193", "species_109877", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10676460": { "compartment": "compartment_7660", "id": "reaction_10676460", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676365", "species_10676370" ], "products": [ "species_10676372" ], "modifiers": [], "additional_components": [ "DDB_G0290331", "DDB_G0282677", "Q54S43", "DDB_G0282677", "Q54G78", "DDB_G0290331" ] }, "reaction_10676464": { "compartment": "compartment_7660", "id": "reaction_10676464", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676331", "species_10675598" ], "products": [ "species_10676333" ], "modifiers": [], "additional_components": [ "DDB_G0285293", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10674956": { "compartment": "compartment_7660", "id": "reaction_10674956", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674954" ], "products": [ "species_10674193", "species_10673970", "species_75897", "species_10672167" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676468": { "compartment": "compartment_7660", "id": "reaction_10676468", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676380" ], "products": [ "species_10676380" ], "modifiers": [], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55F13", "DDB_G0268678", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q75JA4", "DDB_G0271690", "Q55D17", "DDB_G0269814", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10676474": { "compartment": "compartment_7660", "id": "reaction_10676474", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10676476": { "compartment": "compartment_7660", "id": "reaction_10676476", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676442" ], "products": [ "species_10676442" ], "modifiers": [], "additional_components": [ "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331", "Q54YG9", "DDB_G0278241", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q55F13", "DDB_G0268678", "Q555G9", "DDB_G0274885", "Q86A81", "DDB_G0274327", "Q54FA8", "DDB_G0291037", "Q54NF2", "DDB_G0285293", "Q54Q08", "DDB_G0284195", "species_6806881", "Q75JA4", "DDB_G0271690", "Q54Y92", "DDB_G0277841", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54Q05", "DDB_G0284201", "Q54J75", "DDB_G0288257", "Q55AD4", "DDB_G0271948", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54S43", "DDB_G0282677", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q556Z2", "DDB_G0273207", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54S59", "DDB_G0282793", "Q54KT7", "DDB_G0287131", "Q54LP1", "DDB_G0286523", "Q55E33", "DDB_G0269412", "Q55A48", "DDB_G0272354", "Q54MB8", "DDB_G0286051", "Q54G78", "DDB_G0290331" ] }, "reaction_10674860": { "compartment": "compartment_7660", "id": "reaction_10674860", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674858" ], "products": [ "species_10674193", "species_110068", "species_10673970", "species_10674181", "species_10672167", "species_10674115", "species_10674110" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54ND1", "DDB_G0285343", "Q54FA8", "DDB_G0291037", "Q54G80", "DDB_G0290327", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54KH7", "DDB_G0287337", "Q54R66", "DDB_G0283365", "Q54CN8", "DDB_G0292838", "Q54WV4", "DDB_G0279377", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "P26355", "DDB_G0275617", "Q55F19", "DDB_G0268668", "Q555L9", "DDB_G0274697", "Q55AB6", "DDB_G0272036", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q55A39", "DDB_G0272360", "Q86KZ2", "DDB_G0272362", "Q557M8", "DDB_G0273525", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54CN8", "DDB_G0292838", "Q54DH8", "DDB_G0292242", "Q54XM9", "DDB_G0278843", "Q54IW7", "DDB_G0288471", "Q54X70", "DDB_G0279179", "P26355", "DDB_G0275617", "Q555L9", "DDB_G0274697", "C7G081", "DDB_G0292724", "Q55BH6", "DDB_G0271338", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0290929", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327" ] }, "reaction_10724807": { "compartment": "compartment_17938", "id": "reaction_10724807", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724887", "species_10677461" ], "products": [ "species_10724894" ], "modifiers": [], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "Q54D08", "DDB_G0292592", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091" ] }, "reaction_10724881": { "compartment": "compartment_17938", "id": "reaction_10724881", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_10724875" ], "products": [ "species_10724877", "species_10724879" ], "modifiers": [], "additional_components": [ "Q54UN5", "DDB_G0280947", "Q54WU6", "DDB_G0279427", "Q54JS5", "DDB_G0287817", "Q55BD9", "DDB_G0271288", "Q551B5", "DDB_G0276673", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54XA2", "DDB_G0279099", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54UN5", "DDB_G0280947", "Q54JS5", "DDB_G0287817", "Q551B5", "DDB_G0276673", "Q55BD9", "DDB_G0271288", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q86K39", "DDB_G0277257", "Q54NW3", "DDB_G0284957", "Q55DE8", "DDB_G0269680", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q54XA2", "DDB_G0279099", "Q54WU6", "DDB_G0279427", "species_29588" ] }, "reaction_10724892": { "compartment": "compartment_17938", "id": "reaction_10724892", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10724885" ], "products": [ "species_10724889", "species_29420" ], "modifiers": [ [ "species_10724885", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "species_29468", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701" ] }, "reaction_10724992": { "compartment": "compartment_17938", "id": "reaction_10724992", "reactome": "R-DDI-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724800" ], "products": [ "species_10724804", "species_29372" ], "modifiers": [ [ "species_10724800", "catalyst" ], [ "species_10724990", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54PK6", "DDB_G0284495", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q55AH5", "DDB_G0271882", "Q54QW5", "DDB_G0283567", "Q86A77", "DDB_G0274331", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "species_29438", "Q86J23", "DDB_G0274833", "Q86AS7", "DDB_G0274141", "species_29420", "P54641", "DDB_G0273071", "P54648", "DDB_G0284473", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54IK1", "DDB_G0288701", "Q54Z13", "DDB_G0277971", "Q54F59", "DDB_G0291091", "Q54HT9", "DDB_G0289243", "Q54UF2", "DDB_G0281111" ] }, "reaction_10726077": { "compartment": "compartment_12045", "id": "reaction_10726077", "reactome": "R-DDI-9717214", "name": "I(1,4,5)P3 binds ITPR3 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114520", "species_10683360" ], "products": [ "species_10683368" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10726080": { "compartment": "compartment_12045", "id": "reaction_10726080", "reactome": "R-DDI-9717215", "name": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111875" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10683368", "catalyst" ] ], "additional_components": [ "species_114520", "Q9NA13", "DDB_G0292564" ] }, "reaction_10702919": { "compartment": "compartment_7660", "id": "reaction_10702919", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702917" ], "products": [ "species_10669917", "species_10702915" ], "modifiers": [ [ "species_10678738", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10702926": { "compartment": "compartment_7660", "id": "reaction_10702926", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10702923", "species_10669917" ], "products": [ "species_10702917" ], "modifiers": [ [ "species_10702923", "catalyst" ] ], "additional_components": [ "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428", "Q559B8", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54D90", "DDB_G0292428", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q54WU7", "DDB_G0292428" ] }, "reaction_10687980": { "compartment": "compartment_70101", "id": "reaction_10687980", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687942", "species_10687976" ], "products": [ "species_10687978" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "Q54IK3", "DDB_G0290547", "Q86L44", "DDB_G0294407", "Q54Q67", "DDB_G0284145", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547" ] }, "reaction_10686695": { "compartment": "compartment_876", "id": "reaction_10686695", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10686697": { "compartment": "compartment_876", "id": "reaction_10686697", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10686692", "catalyst" ] ], "additional_components": [ "Q54WT8", "DDB_G0279443", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10680301": { "compartment": "compartment_70101", "id": "reaction_10680301", "reactome": "R-DDI-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10680099" ], "products": [ "species_10680289", "species_29372" ], "modifiers": [ [ "species_10680298", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54AX5", "DDB_G0294094", "species_29418" ] }, "reaction_10680303": { "compartment": "compartment_876", "id": "reaction_10680303", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680166", "species_10680149" ], "products": [ "species_10680168" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q556W3", "DDB_G0273293", "species_179838" ] }, "reaction_10718529": { "compartment": "compartment_984", "id": "reaction_10718529", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718524", "species_109276" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10718524", "catalyst" ] ], "additional_components": [ "Q54XV8", "DDB_G0278563", "species_6789198", "species_1236719", "CHEBI:21615", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10715120": { "compartment": "compartment_984", "id": "reaction_10715120", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677636", "species_6803081" ], "products": [ "species_10715118" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_6803081" ] }, "reaction_10718526": { "compartment": "compartment_984", "id": "reaction_10718526", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712951", "species_6789198" ], "products": [ "species_10718524" ], "modifiers": [], "additional_components": [ "DDB_G0278563", "Q54XV8", "DDB_G0278563", "species_6789198" ] }, "reaction_10700306": { "compartment": "compartment_7660", "id": "reaction_10700306", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700290" ], "products": [ "species_10700304" ], "modifiers": [], "additional_components": [ "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855" ] }, "reaction_10700369": { "compartment": "compartment_70101", "id": "reaction_10700369", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700363" ], "products": [ "species_10700367" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "Q7Z2B8", "DDB_G0277917", "CHEBI:29034", "Q55G87", "DDB_G0267446", "P02599", "DDB_G0279407", "species_29426", "O00897", "DDB_G0269104", "Q7YSW8", "DDB_G0276883", "species_74016", "CHEBI:29034", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10700238": { "compartment": "compartment_70101", "id": "reaction_10700238", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10700235", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "B0G0Y8", "DDB_G0268634", "species_29438" ] }, "reaction_10702112": { "compartment": "compartment_70101", "id": "reaction_10702112", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5673778", "species_428040" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10702109", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10684759": { "compartment": "compartment_876", "id": "reaction_10684759", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_188972" ], "products": [ "species_352022", "species_425425" ], "modifiers": [ [ "species_10684756", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10684628": { "compartment": "compartment_20699", "id": "reaction_10684628", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10684625", "catalyst" ] ], "additional_components": [ "DDB_G0281877" ] }, "reaction_10722684": { "compartment": "compartment_70101", "id": "reaction_10722684", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722681", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720523": { "compartment": "compartment_70101", "id": "reaction_10720523", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10720520", "catalyst" ] ], "additional_components": [ "Q7KWK4", "DDB_G0276801", "Q55GN9", "DDB_G0276801" ] }, "reaction_10720514": { "compartment": "compartment_70101", "id": "reaction_10720514", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10720511", "catalyst" ] ], "additional_components": [ "DDB_G0276663" ] }, "reaction_10684806": { "compartment": "compartment_201753", "id": "reaction_10684806", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428548", "species_29404" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10684803", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10684991": { "compartment": "compartment_876", "id": "reaction_10684991", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10684988", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_30034", "species_70113", "species_29532", "species_30034", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684892": { "compartment": "compartment_876", "id": "reaction_10684892", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_83910", "species_29372" ], "modifiers": [ [ "species_10684889", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761" ] }, "reaction_10722668": { "compartment": "compartment_70101", "id": "reaction_10722668", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722665", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684623": { "compartment": "compartment_876", "id": "reaction_10684623", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_83910", "species_351626" ], "modifiers": [ [ "species_10684620", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10685930": { "compartment": "compartment_70101", "id": "reaction_10685930", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10722673": { "compartment": "compartment_70101", "id": "reaction_10722673", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10722670", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10702091": { "compartment": "compartment_70101", "id": "reaction_10702091", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685921", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720498": { "compartment": "compartment_70101", "id": "reaction_10720498", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29404" ], "products": [ "species_113552", "species_113529" ], "modifiers": [ [ "species_10720493", "catalyst" ] ], "additional_components": [ "DDB_G0276933" ] }, "reaction_10685010": { "compartment": "compartment_876", "id": "reaction_10685010", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10685007", "catalyst" ] ], "additional_components": [ "Q54UC8", "DDB_G0281155", "Q54M69", "DDB_G0286151" ] }, "reaction_10722686": { "compartment": "compartment_70101", "id": "reaction_10722686", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10720653": { "compartment": "compartment_70101", "id": "reaction_10720653", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10720650", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10684972": { "compartment": "compartment_876", "id": "reaction_10684972", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10684969", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10685927": { "compartment": "compartment_70101", "id": "reaction_10685927", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685923" ], "products": [ "species_113592", "species_10685921" ], "modifiers": [], "additional_components": [ "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10702698": { "compartment": "compartment_70101", "id": "reaction_10702698", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10702695", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10685925": { "compartment": "compartment_70101", "id": "reaction_10685925", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10685921" ], "products": [ "species_10685923" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10684742": { "compartment": "compartment_876", "id": "reaction_10684742", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10684739", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10715026": { "compartment": "compartment_7660", "id": "reaction_10715026", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715020" ], "products": [ "species_10680330" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10715023": { "compartment": "compartment_7660", "id": "reaction_10715023", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715006", "species_113518" ], "products": [ "species_10715020", "species_10669917" ], "modifiers": [ [ "species_10698755", "catalyst" ], [ "species_10698438", "inhibitor" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10721791": { "compartment": "compartment_70101", "id": "reaction_10721791", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10721783" ], "products": [ "species_29370", "species_10721788" ], "modifiers": [ [ "species_10677526", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10717104": { "compartment": "compartment_70101", "id": "reaction_10717104", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10680330" ], "products": [ "species_29370", "species_10717102" ], "modifiers": [ [ "species_10697880", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54LR6", "DDB_G0286481", "Q02720", "DDB_G0276885", "Q54PF1", "DDB_G0284601" ] }, "reaction_10715008": { "compartment": "compartment_70101", "id": "reaction_10715008", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714984" ], "products": [ "species_10715006" ], "modifiers": [], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920" ] }, "reaction_10721861": { "compartment": "compartment_70101", "id": "reaction_10721861", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_10680330" ], "products": [ "species_10721849", "species_197277" ], "modifiers": [ [ "species_10721858", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q86J21", "DDB_G0274293" ] }, "reaction_10721834": { "compartment": "compartment_70101", "id": "reaction_10721834", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689058", "species_113592" ], "products": [ "species_29370", "species_10721832" ], "modifiers": [ [ "species_10680099", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10721837": { "compartment": "compartment_70101", "id": "reaction_10721837", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715071" ], "modifiers": [ [ "species_10721832", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "DDB_G0281657" ] }, "reaction_10715083": { "compartment": "compartment_70101", "id": "reaction_10715083", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10715073", "species_29356" ], "products": [ "species_10670153", "species_10680330" ], "modifiers": [ [ "species_10715080", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10717150": { "compartment": "compartment_70101", "id": "reaction_10717150", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10717148" ], "products": [ "species_10670153" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10721793": { "compartment": "compartment_13231", "id": "reaction_10721793", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721783" ], "products": [ "species_10721781" ], "modifiers": [ [ "species_10677526", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10715054": { "compartment": "compartment_70101", "id": "reaction_10715054", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10680330" ], "products": [ "species_10715043" ], "modifiers": [ [ "species_10715051", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q553B4", "DDB_G0292920", "Q54JL7", "DDB_G0287969", "Q8T9S7", "DDB_G0286557", "Q54MG8", "DDB_G0292920", "Q54CH3", "DDB_G0292920", "Q54QF1", "DDB_G0283983", "C7G034", "DDB_G0285063" ] }, "reaction_10686632": { "compartment": "compartment_70101", "id": "reaction_10686632", "reactome": "R-DDI-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686100" ], "products": [ "species_10686630" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10686107": { "compartment": "compartment_70101", "id": "reaction_10686107", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10686094" ], "products": [ "species_29370", "species_10686046" ], "modifiers": [ [ "species_10680089", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10686113": { "compartment": "compartment_70101", "id": "reaction_10686113", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686092", "species_450523" ], "products": [ "species_10686094" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10686104": { "compartment": "compartment_70101", "id": "reaction_10686104", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10686094", "species_10685110", "species_10685181" ], "products": [ "species_10686102" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "Q54MG5", "DDB_G0285973", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251" ] }, "reaction_10686050": { "compartment": "compartment_70101", "id": "reaction_10686050", "reactome": "R-DDI-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686046" ], "products": [ "species_10686048" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138" ] }, "reaction_10679303": { "compartment": "compartment_876", "id": "reaction_10679303", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10679300", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10679314": { "compartment": "compartment_876", "id": "reaction_10679314", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10679311", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_29590", "species_70113", "species_29532", "species_29590", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10725864": { "compartment": "compartment_70101", "id": "reaction_10725864", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629770", "species_10701655", "species_994146", "species_994141" ], "products": [ "species_10725862" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994146", "species_1629770", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_994141" ] }, "reaction_10725860": { "compartment": "compartment_70101", "id": "reaction_10725860", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_10725858" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "species_113592", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10709720": { "compartment": "compartment_70101", "id": "reaction_10709720", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5692450" ], "products": [ "species_29370", "species_29372", "species_5692484" ], "modifiers": [ [ "species_10709717", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10687988": { "compartment": "compartment_20699", "id": "reaction_10687988", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_209799" ], "products": [ "species_29370", "species_936901", "species_29372" ], "modifiers": [ [ "species_10687985", "catalyst" ] ], "additional_components": [ "DDB_G0284141" ] }, "reaction_10688162": { "compartment": "compartment_70101", "id": "reaction_10688162", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_947588", "species_29356" ], "products": [ "species_29370", "species_947594", "species_29372" ], "modifiers": [ [ "species_10688101", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500646", "species_1500581", "Q54L55", "DDB_G0286891", "Q553A4", "DDB_G0281401", "Q55E09", "DDB_G0270870", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0281401", "Q551T0", "DDB_G0281401", "Q55E61", "DDB_G0286891" ] }, "reaction_10701952": { "compartment": "compartment_70101", "id": "reaction_10701952", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29356", "species_5252122" ], "products": [ "species_29370", "species_5252016", "species_29372" ], "modifiers": [ [ "species_10701949", "catalyst" ] ], "additional_components": [ "Q54X63", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10709709": { "compartment": "compartment_70101", "id": "reaction_10709709", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29418", "species_29356" ], "products": [ "species_29370", "species_29372", "species_1981162" ], "modifiers": [ [ "species_10709706", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10696020": { "compartment": "compartment_161320", "id": "reaction_10696020", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10696017", "catalyst" ] ], "additional_components": [ "P54639", "DDB_G0278721", "Q559Q3", "DDB_G0291191", "Q94503", "DDB_G0279185", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q94504", "DDB_G0279187", "Q23894", "DDB_G0283867", "P04989", "DDB_G0279799", "Q54RQ2", "DDB_G0282991", "P54640", "DDB_G0272815", "Q54UH3", "DDB_G0282991" ] }, "reaction_10702333": { "compartment": "compartment_70101", "id": "reaction_10702333", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10702330", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10710970": { "compartment": "compartment_1660541", "id": "reaction_10710970", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710940" ], "products": [ "species_10710968" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10716374": { "compartment": "compartment_70101", "id": "reaction_10716374", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163579", "species_29356" ], "products": [ "species_216762", "species_8876730" ], "modifiers": [ [ "species_10716371", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10720699": { "compartment": "compartment_161320", "id": "reaction_10720699", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720695", "species_10720691" ], "products": [ "species_10720689", "species_10720697" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q9TVK6", "DDB_G0269158", "species_216762" ] }, "reaction_10710972": { "compartment": "compartment_1660541", "id": "reaction_10710972", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10710968" ], "products": [ "species_10710966" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10720693": { "compartment": "compartment_161320", "id": "reaction_10720693", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10720689" ], "products": [ "species_10720691" ], "modifiers": [], "additional_components": [ "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "species_216762", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185" ] }, "reaction_10720701": { "compartment": "compartment_12045", "id": "reaction_10720701", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10720697" ], "products": [ "species_193384", "species_10720695" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10705109": { "compartment": "compartment_12045", "id": "reaction_10705109", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10705051" ], "products": [ "species_10705071" ], "modifiers": [], "additional_components": [ "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T6J5", "DDB_G0267438", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q54R52", "DDB_G0283387", "Q8T5Z7", "DDB_G0291994", "Q55BC0", "DDB_G0271138" ] }, "reaction_10718240": { "compartment": "compartment_876", "id": "reaction_10718240", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718230" ], "products": [ "species_10718238" ], "modifiers": [], "additional_components": [ "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q8MN58", "DDB_G0277403", "P25870", "DDB_G0277221", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721" ] }, "reaction_10718758": { "compartment": "compartment_70616", "id": "reaction_10718758", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_10718738" ], "products": [ "species_10718750", "species_10718744" ], "modifiers": [ [ "species_10718755", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10677317": { "compartment": "compartment_5460", "id": "reaction_10677317", "reactome": "R-DDI-163296", "name": "Association of TFAM:mt promoter complex with POLRMT:TFB2M", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677313", "species_10677301" ], "products": [ "species_10677315" ], "modifiers": [], "additional_components": [ "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260", "Q54M56", "DDB_G0286199", "Q95NZ8", "DDB_G0267416", "Q55C24", "DDB_G0270260" ] }, "reaction_10677319": { "compartment": "compartment_5460", "id": "reaction_10677319", "reactome": "R-DDI-163310", "name": "TFAM binds to mitochondrial promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163305", "species_10677299" ], "products": [ "species_10677301" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10701526": { "compartment": "compartment_70101", "id": "reaction_10701526", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701518", "species_113592" ], "products": [ "species_29370", "species_10698937" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701523": { "compartment": "compartment_70101", "id": "reaction_10701523", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701516" ], "products": [ "species_10701518", "species_29370" ], "modifiers": [ [ "species_10701516", "catalyst" ], [ "species_10701521", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "LigandDisplayForward?ligandId=5711", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "LigandDisplayForward?ligandId=5698", "Q54XX5", "DDB_G0278535", "LigandDisplayForward?ligandId=5890" ] }, "reaction_10701651": { "compartment": "compartment_70101", "id": "reaction_10701651", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698939", "species_10701647" ], "products": [ "species_10701649" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10702537": { "compartment": "compartment_876", "id": "reaction_10702537", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698980", "species_5620974" ], "products": [ "species_10702526" ], "modifiers": [ [ "species_10702535", "inhibitor" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_1806180", "species_179838", "species_179856", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "species_1806180", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "species_179838", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "species_179856", "Q54HC6", "DDB_G0289555", "Q8T7K0", "DDB_G0275451", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535" ] }, "reaction_10701658": { "compartment": "compartment_70101", "id": "reaction_10701658", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10701649" ], "products": [ "species_29370", "species_10701655" ], "modifiers": [ [ "species_10701649", "catalyst" ] ], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54U31", "DDB_G0281343", "Q54N73", "DDB_G0285463", "Q54Y55", "DDB_G0278409", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q54RB7", "DDB_G0283267", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54U31", "DDB_G0281343", "Q54Y55", "DDB_G0278409", "Q54XX5", "DDB_G0278535", "Q54IP4", "DDB_G0288617", "Q54G43", "DDB_G0290451" ] }, "reaction_10701653": { "compartment": "compartment_70101", "id": "reaction_10701653", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698937" ], "products": [ "species_10698939" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535", "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54N73", "DDB_G0285463", "Q54XX5", "DDB_G0278535" ] }, "reaction_10697256": { "compartment": "compartment_70101", "id": "reaction_10697256", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10683777" ], "products": [ "species_10680149" ], "modifiers": [], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10724239": { "compartment": "compartment_17951", "id": "reaction_10724239", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10724169" ], "products": [ "species_10724234", "species_10724236" ], "modifiers": [ [ "species_10724169", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10683109": { "compartment": "compartment_70101", "id": "reaction_10683109", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680440", "species_76577" ], "products": [ "species_10683107" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10683111": { "compartment": "compartment_70101", "id": "reaction_10683111", "reactome": "R-DDI-380942", "name": "LKB1 forms a trimeric complex with STRAD and MO25", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680445", "species_10680470", "species_10680454" ], "products": [ "species_10680472" ], "modifiers": [], "additional_components": [ "DDB_G0270680", "Q551H4", "DDB_G0276577", "Q54XL6", "DDB_G0278863", "C7G028", "DDB_G0284307", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10680475": { "compartment": "compartment_70101", "id": "reaction_10680475", "reactome": "R-DDI-200421", "name": "Activation of cytosolic AMPK by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680420", "species_113592" ], "products": [ "species_29370", "species_10680440" ], "modifiers": [ [ "species_10680472", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "Q54MV2", "DDB_G0285643", "C7G028", "DDB_G0284307", "Q551H4", "DDB_G0276577", "Q55CW1", "DDB_G0270680", "Q54XL6", "DDB_G0278863" ] }, "reaction_10685835": { "compartment": "compartment_876", "id": "reaction_10685835", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677526", "species_113592" ], "products": [ "species_10677585", "species_29370" ], "modifiers": [ [ "species_10683107", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54UG7", "DDB_G0281089", "Q54YF2", "DDB_G0277905", "Q8T277", "DDB_G0272542", "species_76577", "Q54MV2", "DDB_G0285643" ] }, "reaction_10703641": { "compartment": "compartment_17938", "id": "reaction_10703641", "reactome": "R-DDI-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10677539" ], "products": [ "species_10677541" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677561": { "compartment": "compartment_17938", "id": "reaction_10677561", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673347", "species_113592" ], "products": [ "species_29370", "species_10677534" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677545", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10702256": { "compartment": "compartment_70101", "id": "reaction_10702256", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_29360", "species_29356" ], "products": [ "species_70106", "species_73473", "species_5334816" ], "modifiers": [ [ "species_10702253", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54IU0", "DDB_G0290537", "Q54FY2", "DDB_G0290537", "Q54FY1", "DDB_G0290537" ] }, "reaction_10677608": { "compartment": "compartment_70101", "id": "reaction_10677608", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677603" ], "products": [ "species_29370", "species_10677606" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "DDB_G0286125" ] }, "reaction_10682921": { "compartment": "compartment_17938", "id": "reaction_10682921", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677545" ], "products": [ "species_29370", "species_10677539" ], "modifiers": [ [ "species_10680774", "catalyst" ] ], "additional_components": [ "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10703164": { "compartment": "compartment_17938", "id": "reaction_10703164", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677522", "species_10677461" ], "products": [ "species_10677524" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q86C65", "DDB_G0281569", "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833" ] }, "reaction_10702550": { "compartment": "compartment_70616", "id": "reaction_10702550", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623648", "species_5623644", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10702547", "catalyst" ] ], "additional_components": [ "DDB_G0288917" ] }, "reaction_10726000": { "compartment": "compartment_7660", "id": "reaction_10726000", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10721488" ], "products": [ "species_10721490" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677587": { "compartment": "compartment_17938", "id": "reaction_10677587", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677571", "species_113592" ], "products": [ "species_29370", "species_10677575" ], "modifiers": [ [ "species_10677526", "catalyst" ], [ "species_10677541", "catalyst" ], [ "species_10677559", "inhibitor" ], [ "species_10677585", "inhibitor" ] ], "additional_components": [ "DDB_G0286125", "DDB_G0286125", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677598": { "compartment": "compartment_70101", "id": "reaction_10677598", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673172" ], "products": [ "species_29370", "species_10677595" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "DDB_G0286125" ] }, "reaction_10702269": { "compartment": "compartment_70101", "id": "reaction_10702269", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_975622" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10702266", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10703166": { "compartment": "compartment_70101", "id": "reaction_10703166", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677518", "species_10677490" ], "products": [ "species_10677520" ], "modifiers": [], "additional_components": [ "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10710352": { "compartment": "compartment_70101", "id": "reaction_10710352", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5362565", "species_29360", "species_29356" ], "products": [ "species_73473", "species_70106", "species_5362520" ], "modifiers": [ [ "species_10710349", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10702261": { "compartment": "compartment_70101", "id": "reaction_10702261", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_73473", "species_975622" ], "modifiers": [ [ "species_10702258", "catalyst" ] ], "additional_components": [ "Q54TC2", "DDB_G0281865", "species_29426" ] }, "reaction_10703160": { "compartment": "compartment_17938", "id": "reaction_10703160", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677478", "species_10677473", "species_10677488", "species_10677468", "species_10677483" ], "products": [ "species_10677490" ], "modifiers": [], "additional_components": [ "DDB_G0274833", "DDB_G0291091", "DDB_G0283567", "DDB_G0292160", "DDB_G0291948", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10703650": { "compartment": "compartment_17938", "id": "reaction_10703650", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10677541" ], "products": [ "species_29370", "species_10703647" ], "modifiers": [ [ "species_10677541", "catalyst" ] ], "additional_components": [ "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q54DY3", "DDB_G0291948", "P54632", "DDB_G0269138", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "P54632", "DDB_G0269138", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10677566": { "compartment": "compartment_70101", "id": "reaction_10677566", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677534" ], "products": [ "species_10673316", "species_10677532" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0268574", "DDB_G0291990" ] }, "reaction_10697038": { "compartment": "compartment_70101", "id": "reaction_10697038", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_179856" ], "products": [ "species_10697036" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179856" ] }, "reaction_10721494": { "compartment": "compartment_7660", "id": "reaction_10721494", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10721482", "species_1254400" ], "products": [ "species_10721484" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "Q54WQ9", "DDB_G0279491", "Q55FM3", "DDB_G0268042", "species_113592", "P54651", "DDB_G0267400", "Q54RH6", "DDB_G0283157", "species_1254400" ] }, "reaction_10677528": { "compartment": "compartment_70101", "id": "reaction_10677528", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677524", "species_10677442" ], "products": [ "species_10677526" ], "modifiers": [], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54D08", "DDB_G0292592", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "Q550Q4", "DDB_G0277041", "species_29438", "Q54DY3", "DDB_G0291948", "Q55BR7", "DDB_G0270398", "Q54QW5", "DDB_G0283567", "species_29438", "Q86C65", "DDB_G0281569", "Q86J23", "DDB_G0274833", "species_29420", "Q54D08", "DDB_G0292592", "Q550Q4", "DDB_G0277041", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091" ] }, "reaction_10692083": { "compartment": "compartment_70101", "id": "reaction_10692083", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10692076" ], "products": [ "species_10692080" ], "modifiers": [ [ "species_10692076", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267" ] }, "reaction_10722291": { "compartment": "compartment_70101", "id": "reaction_10722291", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10677522", "catalyst" ] ], "additional_components": [ "species_29420", "Q54DY3", "DDB_G0291948", "Q54QW5", "DDB_G0283567", "Q1ZXA8", "DDB_G0292160", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833" ] }, "reaction_10725838": { "compartment": "compartment_70101", "id": "reaction_10725838", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677557", "species_9678687" ], "products": [ "species_10677559" ], "modifiers": [], "additional_components": [ "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227", "species_9678687", "Q54UR2", "DDB_G0280877", "Q554J3", "DDB_G0275227" ] }, "reaction_10698857": { "compartment": "compartment_20699", "id": "reaction_10698857", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10698851" ], "products": [ "species_10698855" ], "modifiers": [], "additional_components": [ "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q54IF7", "DDB_G0288787", "Q55CA0", "DDB_G0269168" ] }, "reaction_10723074": { "compartment": "compartment_7660", "id": "reaction_10723074", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10723069" ], "products": [ "species_113582", "species_10723071" ], "modifiers": [ [ "species_10723069", "catalyst" ] ], "additional_components": [ "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "Q54LJ0", "DDB_G0286617", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q86JJ5", "DDB_G0277677", "Q54LJ0", "DDB_G0286617", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10703162": { "compartment": "compartment_70101", "id": "reaction_10703162", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677503", "species_10677516" ], "products": [ "species_10677518" ], "modifiers": [], "additional_components": [ "species_29438", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29438", "Q54IK1", "DDB_G0288701" ] }, "reaction_10677615": { "compartment": "compartment_70101", "id": "reaction_10677615", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10673321" ], "products": [ "species_29370", "species_10677613" ], "modifiers": [ [ "species_10677575", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "DDB_G0286125" ] }, "reaction_10677444": { "compartment": "compartment_17938", "id": "reaction_10677444", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10677440" ], "products": [ "species_10677442", "species_29420" ], "modifiers": [], "additional_components": [ "species_29420", "Q550Q4", "DDB_G0277041", "Q550Q4", "DDB_G0277041", "species_29438" ] }, "reaction_10692085": { "compartment": "compartment_70101", "id": "reaction_10692085", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10692080" ], "products": [ "species_10670153", "species_10692072" ], "modifiers": [ [ "species_10670356", "catalyst" ] ], "additional_components": [ "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54NZ5", "DDB_G0284903", "Q54K33", "DDB_G0287629", "Q86J11", "DDB_G0274267", "Q55BF8", "DDB_G0274267", "Q54QR2", "DDB_G0283679", "Q86A21", "DDB_G0272969", "P34124", "DDB_G0292382", "Q54DM7", "DDB_G0292122", "Q54UJ0", "DDB_G0281051", "Q55BV5", "DDB_G0270784", "Q54DB2", "DDB_G0292398", "Q55G04", "DDB_G0268538", "Q54XM7", "DDB_G0278847", "Q86IJ1", "DDB_G0272566", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "P34123", "DDB_G0289003", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54MB0", "DDB_G0286067", "Q27563", "DDB_G0267408", "Q556Q0", "DDB_G0273163", "P34120", "DDB_G0272831", "Q86JA1", "DDB_G0276917", "Q553E0", "DDB_G0275775", "Q54UB5", "DDB_G0281315", "P34119", "DDB_G0280969", "Q54BC8", "DDB_G0293784", "Q54S82", "DDB_G0282617", "Q54PJ1", "DDB_G0284517", "Q54WI8", "DDB_G0279633", "Q559F4", "DDB_G0272951", "Q55GJ6", "DDB_G0267390", "Q55DY7", "DDB_G0269472", "Q1ZXD3", "DDB_G0288621", "P02889", "DDB_G0272564", "Q54BC6", "DDB_G0293752", "Q54JM5", "DDB_G0287953", "Q552Y8", "DDB_G0275753", "Q27562", "DDB_G0282363" ] }, "reaction_10689651": { "compartment": "compartment_70101", "id": "reaction_10689651", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689645", "species_10689647" ], "products": [ "species_10689649" ], "modifiers": [], "additional_components": [ "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q9GPS0", "DDB_G0269178", "P34144", "DDB_G0277869", "Q9GPS0", "DDB_G0269178", "Q86I66", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "P34144", "DDB_G0277869", "Q54DW1", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q55BQ8", "DDB_G0292004", "Q54PB7", "DDB_G0292004" ] }, "reaction_10689421": { "compartment": "compartment_70101", "id": "reaction_10689421", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689367" ], "products": [ "species_10689369" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10689432": { "compartment": "compartment_7660", "id": "reaction_10689432", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689428", "species_10689425" ], "products": [ "species_10689430" ], "modifiers": [], "additional_components": [ "DDB_G0267402", "DDB_G0283023", "Q54RN0", "DDB_G0283023", "O15819", "DDB_G0267402" ] }, "reaction_10697214": { "compartment": "compartment_70101", "id": "reaction_10697214", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994146" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689440": { "compartment": "compartment_70101", "id": "reaction_10689440", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689423": { "compartment": "compartment_70101", "id": "reaction_10689423", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10689374" ], "products": [ "species_10689376" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10689514": { "compartment": "compartment_5460", "id": "reaction_10689514", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113525", "species_113581" ], "modifiers": [ [ "species_10689511", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10684256": { "compartment": "compartment_984", "id": "reaction_10684256", "reactome": "R-DDI-419490", "name": "Binding of ATP to P2X receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10676753", "species_114570" ], "products": [ "species_10676755" ], "modifiers": [], "additional_components": [ "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335", "Q553Y1", "DDB_G0275293", "Q553Y0", "DDB_G0275191", "species_113592", "Q86JM7", "DDB_G0272004", "Q54JH4", "DDB_G0288061", "Q54J33", "DDB_G0288335" ] }, "reaction_10689443": { "compartment": "compartment_70101", "id": "reaction_10689443", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10689437", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10689499": { "compartment": "compartment_70101", "id": "reaction_10689499", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687040", "species_10689495" ], "products": [ "species_10689497" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q95VZ3", "DDB_G0292386", "Q54MF0", "DDB_G0293920" ] }, "reaction_10687042": { "compartment": "compartment_70101", "id": "reaction_10687042", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687038", "species_10687033" ], "products": [ "species_10687040" ], "modifiers": [], "additional_components": [ "DDB_G0267374", "DDB_G0272104", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10680829": { "compartment": "compartment_70101", "id": "reaction_10680829", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10680825", "species_202277" ], "products": [ "species_10680827" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_202247", "species_179838", "species_202247", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10724241": { "compartment": "compartment_17947", "id": "reaction_10724241", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10722369", "species_10724179" ], "products": [ "species_10724181" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q94490", "DDB_G0284865", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724072": { "compartment": "compartment_70101", "id": "reaction_10724072", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724057", "species_10724068" ], "products": [ "species_10724070" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724186": { "compartment": "compartment_17947", "id": "reaction_10724186", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724181" ], "products": [ "species_10690046", "species_10724183" ], "modifiers": [ [ "species_10724181", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0290547", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "Q54S31", "DDB_G0282693", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "Q54S31", "DDB_G0282693", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0290547", "Q54FX4", "DDB_G0290547", "Q54N40", "DDB_G0285523", "Q94490", "DDB_G0284865", "Q54C55", "DDB_G0293264", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54IK3", "DDB_G0290547", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q54CL3", "DDB_G0292870", "P14794", "DDB_G0280755" ] }, "reaction_10724348": { "compartment": "compartment_17947", "id": "reaction_10724348", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724328" ], "products": [ "species_10683511", "species_10724346", "species_10683495" ], "modifiers": [], "additional_components": [ "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "DDB_G0281213" ] }, "reaction_10724616": { "compartment": "compartment_70101", "id": "reaction_10724616", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724612" ], "products": [ "species_10724614" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724509": { "compartment": "compartment_70101", "id": "reaction_10724509", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724470", "species_10724505" ], "products": [ "species_10724507" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54XS7", "DDB_G0278773", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0289379", "Q54JV6", "DDB_G0287777", "Q54ZH1", "DDB_G0277565", "Q86L22", "DDB_G0277079", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q553P6", "DDB_G0275381", "Q54DG1", "DDB_G0292270", "Q54LP7", "DDB_G0286511", "Q54YR4", "DDB_G0278117", "Q54VG4", "DDB_G0280345" ] }, "reaction_10724173": { "compartment": "compartment_17947", "id": "reaction_10724173", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724151" ], "products": [ "species_10722365", "species_10724171" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724195": { "compartment": "compartment_70101", "id": "reaction_10724195", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724192", "species_29356" ], "products": [ "species_10670153", "species_10724145", "species_10717909" ], "modifiers": [ [ "species_10724192", "catalyst" ] ], "additional_components": [ "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0286033", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724232": { "compartment": "compartment_17947", "id": "reaction_10724232", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724222" ], "products": [ "species_10724179", "species_10724230" ], "modifiers": [], "additional_components": [ "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "O96759", "DDB_G0286183", "Q54N40", "DDB_G0285523", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54C55", "DDB_G0293264", "Q54WA3", "DDB_G0279801", "Q54MD1", "DDB_G0286033", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339" ] }, "reaction_10724352": { "compartment": "compartment_70101", "id": "reaction_10724352", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683511", "species_10724324" ], "products": [ "species_10724326" ], "modifiers": [], "additional_components": [ "DDB_G0274873", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54CL3", "DDB_G0292870", "Q54DG1", "DDB_G0292270", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10724218": { "compartment": "compartment_70101", "id": "reaction_10724218", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724190", "species_10717909" ], "products": [ "species_10724192" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q553T4", "DDB_G0292046", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0292046", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "Q54DT4", "DDB_G0292046", "P0CG79", "DDB_G0282369", "Q54MD1", "DDB_G0286033", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755" ] }, "reaction_10724175": { "compartment": "compartment_17947", "id": "reaction_10724175", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10724147", "species_10724149" ], "products": [ "species_10724151" ], "modifiers": [], "additional_components": [ "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54CL3", "DDB_G0292870", "Q54N40", "DDB_G0285523", "B0G110", "DDB_G0288735", "Q54QI7", "DDB_G0283813", "Q54RB0", "DDB_G0283261", "Q5FXM5", "DDB_G0270658", "Q7KWR0", "DDB_G0276281", "Q75JL8", "DDB_G0288735", "Q54GT6", "DDB_G0289923", "Q54GQ6", "DDB_G0289993", "Q54XC3", "DDB_G0279049", "Q54C55", "DDB_G0293264", "Q54GK8", "DDB_G0290089", "Q75JR2", "DDB_G0272210", "Q54DA9", "DDB_G0292402", "Q54E41", "DDB_G0291814", "Q8MMS1", "DDB_G0288735", "Q55CT6", "DDB_G0288735", "Q54CL3", "DDB_G0292870", "Q54GC2", "DDB_G0290277", "Q54US8", "DDB_G0280851", "Q54II1", "DDB_G0288735", "Q54MD1", "DDB_G0286033", "Q54XX9", "DDB_G0278529", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54JQ2", "DDB_G0287851", "Q54SS0", "DDB_G0282261", "Q54L96", "DDB_G0286763", "Q556W1", "DDB_G0273291", "O77229", "DDB_G0274595", "Q55CT1", "DDB_G0269912", "Q54XZ0", "DDB_G0277911" ] }, "reaction_10724350": { "compartment": "compartment_17947", "id": "reaction_10724350", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683495", "species_10724326" ], "products": [ "species_10724328" ], "modifiers": [], "additional_components": [ "DDB_G0281213", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194", "Q55FL0", "DDB_G0268564", "Q1ZXK7", "DDB_G0276169", "Q54DG1", "DDB_G0292270", "Q54N40", "DDB_G0285523", "Q54ZX5", "DDB_G0277335", "Q550G0", "DDB_G0277113", "Q54H86", "DDB_G0289623", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q76P23", "DDB_G0272346", "Q54C55", "DDB_G0293264", "Q555I0", "DDB_G0274873", "Q54U86", "DDB_G0281213", "Q54CL3", "DDB_G0292870", "Q8T8P3", "DDB_G0293194" ] }, "reaction_10701703": { "compartment": "compartment_70101", "id": "reaction_10701703", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701694" ], "products": [ "species_10701701" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10702088": { "compartment": "compartment_70101", "id": "reaction_10702088", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10702085", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10702104": { "compartment": "compartment_70101", "id": "reaction_10702104", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702101", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10702099": { "compartment": "compartment_70101", "id": "reaction_10702099", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10702096", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10721599": { "compartment": "compartment_70101", "id": "reaction_10721599", "reactome": "R-DDI-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10721596", "catalyst" ] ], "additional_components": [ "species_188972", "species_209818", "species_188972", "species_209818", "Q54PM1", "DDB_G0284461" ] }, "reaction_10701711": { "compartment": "compartment_70101", "id": "reaction_10701711", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701699", "species_10701707" ], "products": [ "species_10701709" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10675618": { "compartment": "compartment_7660", "id": "reaction_10675618", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113571", "species_10675608" ], "products": [ "species_10675615", "species_111349" ], "modifiers": [ [ "species_10675608", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675632": { "compartment": "compartment_7660", "id": "reaction_10675632", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675625", "species_77087" ], "products": [ "species_10673970", "species_10672159", "species_10675598", "species_10675629", "species_77502" ], "modifiers": [ [ "species_10675625", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q55G81", "DDB_G0267414", "P54685", "DDB_G0285417", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q55F19", "DDB_G0268668", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "O00835", "DDB_G0278729", "Q54I13", "DDB_G0289079", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "DDB_G0287661", "Q54Y13", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675623": { "compartment": "compartment_7660", "id": "reaction_10675623", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675615" ], "products": [ "species_10675620" ], "modifiers": [ [ "species_10675615", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "species_113578", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675606": { "compartment": "compartment_7660", "id": "reaction_10675606", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_10675600", "species_29428" ], "products": [ "species_10675604" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675634": { "compartment": "compartment_7660", "id": "reaction_10675634", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672073", "species_10672078" ], "products": [ "species_10672080" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10675611": { "compartment": "compartment_7660", "id": "reaction_10675611", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675604" ], "products": [ "species_113550", "species_10675608" ], "modifiers": [ [ "species_10675604", "catalyst" ] ], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675627": { "compartment": "compartment_7660", "id": "reaction_10675627", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675620" ], "products": [ "species_10675625" ], "modifiers": [], "additional_components": [ "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54Y13", "DDB_G0278479", "Q54FA8", "DDB_G0291037", "O00835", "DDB_G0278729", "P54685", "DDB_G0285417", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q55FP1", "DDB_G0268014", "Q54J75", "DDB_G0288257", "Q55G81", "DDB_G0267414", "Q86JJ5", "DDB_G0277677", "Q55GG8", "DDB_G0268306", "Q55F19", "DDB_G0268668", "Q55AB6", "DDB_G0272036", "Q54K42", "DDB_G0287661", "Q86IB5", "DDB_G0275517", "Q54I13", "DDB_G0289079", "Q86KZ2", "DDB_G0272362", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54C29", "DDB_G0293228", "Q55CT8", "DDB_G0269906", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199" ] }, "reaction_10675636": { "compartment": "compartment_7660", "id": "reaction_10675636", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672080", "species_10672159" ], "products": [ "species_10672161" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257", "Q54EH2", "DDB_G0291636", "Q54YW8", "DDB_G0278039", "Q54DH7", "DDB_G0292244", "Q86JJ5", "DDB_G0277677", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q55AB6", "DDB_G0272036", "Q54FA8", "DDB_G0291037", "Q54R66", "DDB_G0283365", "Q55D17", "DDB_G0269814", "Q54WV4", "DDB_G0279377", "Q54P04", "DDB_G0284891", "Q54S04", "DDB_G0282739", "Q54KR9", "DDB_G0287197", "Q54KT7", "DDB_G0287131", "Q54J75", "DDB_G0288257" ] }, "reaction_10711945": { "compartment": "compartment_7660", "id": "reaction_10711945", "reactome": "R-DDI-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10711942" ], "products": [ "species_2485002", "species_10704963" ], "modifiers": [ [ "species_10711942", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10722637": { "compartment": "compartment_7660", "id": "reaction_10722637", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111793", "species_10698776" ], "products": [ "species_10698778" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10698781": { "compartment": "compartment_7660", "id": "reaction_10698781", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10698769" ], "products": [ "species_159939", "species_10698771" ], "modifiers": [ [ "species_10698778", "catalyst" ] ], "additional_components": [ "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "Q54HV9", "DDB_G0289193", "Q54LA5", "DDB_G0286747", "Q54WG6", "DDB_G0279667", "O15819", "DDB_G0267402", "Q54LP8", "DDB_G0286509", "Q54BC2", "DDB_G0293758", "Q54HW2", "DDB_G0289187", "Q54HV7", "DDB_G0289197", "Q7KWR7", "DDB_G0276273", "Q76NW2", "DDB_G0276863", "O77033", "DDB_G0269194", "species_71067" ] }, "reaction_10704968": { "compartment": "compartment_7660", "id": "reaction_10704968", "reactome": "R-DDI-5682026", "name": "MRN bound to shortened telomeres activates ATM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10704963" ], "products": [ "species_113582", "species_10704965", "species_10682355" ], "modifiers": [ [ "species_10704963", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546", "DDB_G0275845", "B0G130", "DDB_G0279699", "Q54CS9", "DDB_G0292786", "Q553E9", "DDB_G0275845", "Q54BN2", "DDB_G0293546" ] }, "reaction_10718247": { "compartment": "compartment_984", "id": "reaction_10718247", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855492", "species_351629" ], "products": [ "species_8855489", "species_109276" ], "modifiers": [ [ "species_10718244", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10712967": { "compartment": "compartment_6800173", "id": "reaction_10712967", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712871" ], "products": [ "species_10712965" ], "modifiers": [], "additional_components": [ "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q65YR8", "DDB_G0291834", "Q54V78", "DDB_G0349530", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q65YR7", "DDB_G0280439", "Q54RQ2", "DDB_G0282991", "Q54Q34", "DDB_G0349530", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490", "Q86A67", "DDB_G0274375", "Q54UH2", "DDB_G0282991", "O76856", "DDB_G0279411", "Q54V78", "DDB_G0349530", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P52922", "DDB_G0269148", "Q550I3", "DDB_G0277093", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q54XV8", "DDB_G0278563", "Q75JR2", "DDB_G0272210", "Q55FR5", "DDB_G0267990", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "P54640", "DDB_G0272815", "P05095", "DDB_G0268632", "Q557J6", "DDB_G0273447", "Q54B14", "DDB_G0293986", "Q94503", "DDB_G0279185", "Q23919", "DDB_G0288483", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54HL4", "DDB_G0289365", "P54639", "DDB_G0278721", "P04989", "DDB_G0279799", "Q5R1U3", "DDB_G0277001", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q54RQ2", "DDB_G0282991", "Q65YR7", "DDB_G0280439", "Q54UH3", "DDB_G0282991", "Q55GV9", "DDB_G0267490" ] }, "reaction_10711257": { "compartment": "compartment_21994", "id": "reaction_10711257", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711254", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10714086": { "compartment": "compartment_1470028", "id": "reaction_10714086", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713952" ], "products": [ "species_10714084" ], "modifiers": [], "additional_components": [ "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179", "B0G108", "DDB_G0289251", "Q54ES9", "DDB_G0291358", "Q55FU1", "DDB_G0267952", "Q55CG6", "DDB_G0279583", "Q55FM7", "DDB_G0268034", "P34114", "DDB_G0291123", "Q554H6", "DDB_G0289251", "Q6TMK4", "DDB_G0277275", "Q54SW2", "DDB_G0287185", "Q54VE2", "DDB_G0291259", "Q54JY2", "DDB_G0287739", "Q55F06", "DDB_G0279583", "Q54EZ0", "DDB_G0291259", "P34036", "DDB_G0276355", "Q54EG4", "DDB_G0291524", "Q86A73", "DDB_G0291259", "Q55BL4", "DDB_G0287185", "Q54H23", "DDB_G0289749", "Q54LD6", "DDB_G0286691", "P34098", "DDB_G0292206", "Q54HL4", "DDB_G0289365", "Q54I39", "DDB_G0289029", "Q54P50", "DDB_G0289251", "Q54HT4", "DDB_G0289231", "O96621", "DDB_G0272106", "Q1ZXG4", "DDB_G0282361", "P90532", "DDB_G0288065", "Q54NC1", "DDB_G0285399", "P13723", "DDB_G0287033", "Q54SZ9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "C7FZY2", "DDB_G0295845", "Q54PW0", "DDB_G0284261", "Q00766", "DDB_G0281383", "Q54SZ8", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54YA0", "DDB_G0278345", "Q55G10", "DDB_G0268472", "P24639", "DDB_G0269160", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "Q54XV8", "DDB_G0278563", "Q54WK5", "DDB_G0279583", "Q557G3", "DDB_G0273467", "Q54QQ0", "DDB_G0283701", "Q54TL9", "DDB_G0287185", "Q54HV8", "DDB_G0289195", "P10901", "DDB_G0274391", "Q552J0", "DDB_G0276233", "Q54SE2", "DDB_G0282517", "Q54HS6", "DDB_G0289251", "Q54JY8", "DDB_G0289251", "Q54MV4", "DDB_G0287185", "P32256", "DDB_G0269196", "Q551C1", "DDB_G0276661", "Q54KP7", "DDB_G0287185", "Q54JM5", "DDB_G0287953", "Q55B10", "DDB_G0271490", "P54654", "DDB_G0288769", "Q553U5", "DDB_G0275179" ] }, "reaction_10714758": { "compartment": "compartment_984", "id": "reaction_10714758", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714736" ], "products": [ "species_10714756" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q54UQ2", "DDB_G0280897", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q55FR5", "DDB_G0267990", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "Q23919", "DDB_G0288483", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q7Z2B8", "DDB_G0277917", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q55GA9", "DDB_G0267742", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54GE1", "DDB_G0290217", "Q54VR1", "DDB_G0280187", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q54QK4", "DDB_G0283795", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "O76856", "DDB_G0279411", "P15112", "DDB_G0288373", "P52922", "DDB_G0269148", "Q86IJ1", "DDB_G0272566", "Q54JY2", "DDB_G0287739", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "O00897", "DDB_G0269104", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "O96621", "DDB_G0272106", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "Q54YA0", "DDB_G0278345", "P0CT32", "DDB_G0269136", "Q8MUF9", "DDB_G0269200", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q86JA1", "DDB_G0276917", "Q556U5", "DDB_G0273095", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "Q556Z2", "DDB_G0273207", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "P02599", "DDB_G0279407", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10712473": { "compartment": "compartment_6798757", "id": "reaction_10712473", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712371" ], "products": [ "species_10712471" ], "modifiers": [], "additional_components": [ "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q1ZXB3", "DDB_G0291498", "Q55GN5", "DDB_G0267590", "P20790", "DDB_G0280043", "Q54R04", "DDB_G0283525", "Q54P72", "DDB_G0284755", "Q54GB3", "DDB_G0290363", "P20791", "DDB_G0276399", "Q54F95", "DDB_G0290995", "Q86L51", "DDB_G0272857", "Q54P71", "DDB_G0284755", "Q55EI1", "DDB_G0268890", "Q54H23", "DDB_G0289749", "Q555Z5", "DDB_G0274121", "Q54ET2", "DDB_G0291352", "Q8T6J1", "DDB_G0291245", "Q7YXU4", "DDB_G0293008", "Q54FY7", "DDB_G0290529", "Q556J9", "DDB_G0272889", "Q54K65", "DDB_G0290995", "Q55BC0", "DDB_G0271138", "Q54XS7", "DDB_G0278773", "Q54N33", "DDB_G0285537", "Q8T6J5", "DDB_G0267438", "Q54JT7", "DDB_G0287801", "Q552S3", "DDB_G0275917", "Q55D50", "DDB_G0269790", "Q55GG1", "DDB_G0267688", "Q55BW0", "DDB_G0270340", "O76173", "DDB_G0269174", "Q8T6J2", "DDB_G0274119", "Q86K21", "DDB_G0272875", "Q551J1", "DDB_G0276567", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q8T5Z7", "DDB_G0291994", "Q86H52", "DDB_G0281401", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54PR9", "DDB_G0284363", "Q1ZXA8", "DDB_G0292160", "Q54WG1", "DDB_G0279675", "Q54R52", "DDB_G0283387", "Q551T0", "DDB_G0281401", "Q54BT5", "DDB_G0293436", "P54642", "DDB_G0274381", "Q54DE8", "DDB_G0292310", "Q54LZ3", "DDB_G0286293", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P18613", "DDB_G0291237", "Q54P51", "DDB_G0284791" ] }, "reaction_10686832": { "compartment": "compartment_70101", "id": "reaction_10686832", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677800" ], "products": [ "species_10677804" ], "modifiers": [], "additional_components": [ "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10686854": { "compartment": "compartment_70101", "id": "reaction_10686854", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677816" ], "products": [ "species_10677818" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10711262": { "compartment": "compartment_21994", "id": "reaction_10711262", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10711252" ], "products": [ "species_10711254" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10721333": { "compartment": "compartment_1222282", "id": "reaction_10721333", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789221", "species_1470067", "species_1222719" ], "products": [ "species_1222475", "species_8933637" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677802": { "compartment": "compartment_70101", "id": "reaction_10677802", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677798", "species_622271" ], "products": [ "species_10677800" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10713614": { "compartment": "compartment_1462052", "id": "reaction_10713614", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713428" ], "products": [ "species_10713612" ], "modifiers": [], "additional_components": [ "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991", "Q54QR2", "DDB_G0283679", "O96923", "DDB_G0291125", "Q54UJ0", "DDB_G0281051", "Q54UH2", "DDB_G0282991", "Q556L1", "DDB_G0272590", "P34118", "DDB_G0269156", "Q6TMK4", "DDB_G0277275", "Q54UQ2", "DDB_G0280897", "Q6UK63", "DDB_G0287855", "Q54PG1", "DDB_G0284589", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "P54651", "DDB_G0267400", "Q54SL6", "DDB_G0282395", "O96626", "DDB_G0288319", "Q54EF8", "DDB_G0291536", "Q556T3", "DDB_G0273107", "Q54UB5", "DDB_G0281315", "Q54RF5", "DDB_G0283247", "Q555L5", "DDB_G0274859", "C7G028", "DDB_G0284307", "P10733", "DDB_G0289327", "Q54S93", "DDB_G0282595", "Q86KD1", "DDB_G0274167", "Q54BC6", "DDB_G0293752", "O77229", "DDB_G0274595", "P90532", "DDB_G0288065", "Q54FG5", "DDB_G0290873", "P04989", "DDB_G0279799", "Q54W35", "DDB_G0279909", "Q5R1U3", "DDB_G0277001", "Q1ZXP5", "DDB_G0271058", "Q86A67", "DDB_G0274375", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q00766", "DDB_G0281383", "P36415", "DDB_G0269144", "Q54S11", "DDB_G0291536", "Q54PN7", "DDB_G0284415", "Q55C75", "DDB_G0270188", "Q54NQ0", "DDB_G0285105", "Q54VI4", "DDB_G0280317", "Q54MV3", "DDB_G0285641", "Q556P3", "DDB_G0273153", "Q557J6", "DDB_G0273447", "Q552J0", "DDB_G0276233", "Q94503", "DDB_G0279185", "Q54QS2", "DDB_G0283663", "Q54E35", "DDB_G0291840", "Q54L24", "DDB_G0286945", "Q54SM3", "DDB_G0282359", "Q553X3", "DDB_G0275185", "Q86CR9", "DDB_G0271096", "P0CT31", "DDB_G0269134", "Q65YR7", "DDB_G0280439", "Q86A21", "DDB_G0272969", "Q55E06", "DDB_G0269444", "Q54I79", "DDB_G0288937", "Q5V9E9", "DDB_G0283673", "P15112", "DDB_G0288373", "Q86IJ1", "DDB_G0272566", "Q55FM7", "DDB_G0268034", "Q54PG5", "DDB_G0284571", "Q75JR2", "DDB_G0272210", "Q54QV7", "DDB_G0283575", "Q86I31", "DDB_G0275085", "Q551I6", "DDB_G0291536", "B0G198", "DDB_G0295683", "Q86IG9", "DDB_G0272694", "Q86B03", "DDB_G0276833", "Q54XE8", "DDB_G0279009", "C7G034", "DDB_G0285063", "Q94504", "DDB_G0279187", "Q54I82", "DDB_G0288933", "Q54WI8", "DDB_G0279633", "Q54DD0", "DDB_G0292266", "Q1ZXD3", "DDB_G0288621", "Q54QS3", "DDB_G0283661", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "Q54LY5", "DDB_G0286303", "Q54UH3", "DDB_G0282991", "Q55FF3", "DDB_G0268138", "Q54MA9", "DDB_G0286069", "Q54BF1", "DDB_G0293654", "Q54NE6", "DDB_G0285311", "Q65YR8", "DDB_G0291834", "Q23894", "DDB_G0283867", "P0CT32", "DDB_G0269136", "Q54QQ0", "DDB_G0283701", "P54640", "DDB_G0272815", "Q55EK9", "DDB_G0268628", "Q86JA1", "DDB_G0276917", "P36418", "DDB_G0276453", "P90521", "DDB_G0274111", "Q54K94", "DDB_G0287569", "Q556G3", "DDB_G0272632", "P34093", "DDB_G0279911", "P54639", "DDB_G0278721", "Q9UA41", "DDB_G0280401", "Q55C24", "DDB_G0270260", "Q8WQ85", "DDB_G0288557", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10711260": { "compartment": "compartment_1222282", "id": "reaction_10711260", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1470067", "species_6788973", "species_1222719" ], "products": [ "species_6789150", "species_1222475" ], "modifiers": [ [ "species_10711252", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10677848": { "compartment": "compartment_70101", "id": "reaction_10677848", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10677814" ], "products": [ "species_10677816" ], "modifiers": [], "additional_components": [ "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860" ] }, "reaction_10713716": { "compartment": "compartment_6799371", "id": "reaction_10713716", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713682" ], "products": [ "species_10713714" ], "modifiers": [], "additional_components": [ "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54V78", "DDB_G0349530", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q55BA2", "DDB_G0271242", "Q6UK63", "DDB_G0287855", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54B14", "DDB_G0293986", "Q556T3", "DDB_G0273107", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490", "O76856", "DDB_G0279411", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q54V78", "DDB_G0349530", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q54PB7", "DDB_G0292004", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q6UK63", "DDB_G0287855", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54XV8", "DDB_G0278563", "Q54VR1", "DDB_G0280187", "Q55FS4", "DDB_G0282859", "Q54JM9", "DDB_G0287939", "Q54HV8", "DDB_G0289195", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q556T3", "DDB_G0273107", "Q54B14", "DDB_G0293986", "Q54HL4", "DDB_G0289365", "Q54S62", "DDB_G0294569", "Q86IY4", "DDB_G0274339", "Q55D97", "DDB_G0270626", "Q54Q34", "DDB_G0349530", "Q55GV9", "DDB_G0267490" ] }, "reaction_10714477": { "compartment": "compartment_6800424", "id": "reaction_10714477", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714461" ], "products": [ "species_10714475" ], "modifiers": [], "additional_components": [ "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735", "Q55E78", "DDB_G0275421", "Q54YP0", "DDB_G0278613", "Q553U1", "DDB_G0275421", "Q54H23", "DDB_G0289749", "Q86KI1", "DDB_G0273439", "Q54CI8", "DDB_G0292904", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54QG5", "DDB_G0283893", "Q557H3", "DDB_G0273473", "Q54CM5", "DDB_G0292814", "Q869V1", "DDB_G0276973", "Q869Q3", "DDB_G0274519", "Q54R04", "DDB_G0283525", "Q86A88", "DDB_G0274815", "Q54MJ8", "DDB_G0285897", "Q1ZXA8", "DDB_G0292160", "P34144", "DDB_G0277869", "Q55D50", "DDB_G0269790", "Q86JN1", "DDB_G0272062", "Q54E04", "DDB_G0291858", "Q23924", "DDB_G0284735" ] }, "reaction_10689989": { "compartment": "compartment_1222693", "id": "reaction_10689989", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10689986", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] }, "reaction_10725834": { "compartment": "compartment_70101", "id": "reaction_10725834", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10725772", "species_10677814" ], "products": [ "species_10725832" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860", "Q55E90", "DDB_G0269344", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "P14195", "DDB_G0291860" ] }, "reaction_10714292": { "compartment": "compartment_6799351", "id": "reaction_10714292", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10714270" ], "products": [ "species_10714290" ], "modifiers": [], "additional_components": [ "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013", "Q55FQ9", "DDB_G0267440", "Q1ZXG2", "DDB_G0294577", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q54F95", "DDB_G0290995", "Q54WR4", "DDB_G0279483", "Q54Z55", "DDB_G0277773", "Q54HS9", "DDB_G0289247", "Q86L51", "DDB_G0272857", "Q86A77", "DDB_G0274331", "Q553Y0", "DDB_G0275191", "Q86JM7", "DDB_G0272004", "Q54S39", "DDB_G0282683", "Q54K65", "DDB_G0290995", "Q54QG5", "DDB_G0283893", "Q54CM5", "DDB_G0292814", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q55GC2", "DDB_G0267730", "Q54EU4", "DDB_G0291332", "Q02465", "DDB_G0289075", "Q54J33", "DDB_G0288335", "Q55BW0", "DDB_G0270340", "Q54BH1", "DDB_G0293626", "Q55D94", "DDB_G0269738", "O76173", "DDB_G0269174", "Q553Y1", "DDB_G0275293", "Q55BH9", "DDB_G0271342", "Q551J1", "DDB_G0276567", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54G48", "DDB_G0290407", "Q86H52", "DDB_G0281401", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54F44", "DDB_G0291117", "Q54LX9", "DDB_G0286315", "Q1ZXA8", "DDB_G0292160", "Q54JH4", "DDB_G0288061", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "Q86J23", "DDB_G0274833", "Q54YE6", "DDB_G0284903", "Q9BKJ9", "DDB_G0287035", "Q55GA1", "DDB_G0293626", "Q9XYS8", "DDB_G0267406", "Q6TMJ9", "DDB_G0280061", "Q867X6", "DDB_G0267460", "P18613", "DDB_G0291237", "Q54I48", "DDB_G0289013" ] }, "reaction_10677846": { "compartment": "compartment_70101", "id": "reaction_10677846", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10677842", "species_10677820" ], "products": [ "species_10677844" ], "modifiers": [], "additional_components": [ "Q54HC6", "DDB_G0289555", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54HC6", "DDB_G0289555", "species_622271", "Q55BX4", "DDB_G0280575", "Q54WP6", "DDB_G0280575", "Q86HG9", "DDB_G0278535", "Q54TM7", "DDB_G0281557", "Q54V73", "DDB_G0280575", "species_708341", "P14195", "DDB_G0291860", "Q54XX5", "DDB_G0278535" ] }, "reaction_10712733": { "compartment": "compartment_876", "id": "reaction_10712733", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10712651" ], "products": [ "species_10712731" ], "modifiers": [], "additional_components": [ "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735", "Q54FK8", "DDB_G0290829", "Q54BH0", "DDB_G0293628", "Q54FK4", "DDB_G0290833", "Q54DA7", "DDB_G0292406", "Q55CY7", "DDB_G0270670", "P20790", "DDB_G0280043", "P34144", "DDB_G0277869", "Q1ZXB7", "DDB_G0290791", "P20791", "DDB_G0276399", "Q557I4", "DDB_G0273419", "Q54I34", "DDB_G0289033", "Q552H0", "DDB_G0294571", "Q555Z5", "DDB_G0274121", "Q553Y0", "DDB_G0275191", "Q8T6J1", "DDB_G0291245", "Q86JM7", "DDB_G0272004", "Q54CM5", "DDB_G0292814", "Q55BC0", "DDB_G0271138", "Q8MYF2", "DDB_G0277441", "P36411", "DDB_G0269236", "Q8T6J5", "DDB_G0267438", "Q54J33", "DDB_G0288335", "Q55FK2", "DDB_G0268068", "Q553Y1", "DDB_G0275293", "Q8T6J2", "DDB_G0274119", "Q1ZXB8", "DDB_G0294571", "Q54YP0", "DDB_G0278613", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q8T5Z7", "DDB_G0291994", "Q54DG1", "DDB_G0292270", "P34138", "DDB_G0277865", "Q54RY4", "DDB_G0282899", "Q1ZXB9", "DDB_G0290831", "Q54K36", "DDB_G0293628", "Q54E04", "DDB_G0291858", "Q54R52", "DDB_G0283387", "Q55CT4", "DDB_G0270994", "Q54JH4", "DDB_G0288061", "Q54FK7", "DDB_G0290779", "Q54BT5", "DDB_G0293436", "Q54CI8", "DDB_G0292904", "Q54K32", "DDB_G0287585", "Q54K69", "DDB_G0287553", "O00899", "DDB_G0269140", "Q54FK2", "DDB_G0290793", "Q869Q3", "DDB_G0274519", "Q86JP3", "DDB_G0271984", "Q54FK5", "DDB_G0290789", "Q54LZ3", "DDB_G0286293", "Q1ZXE7", "DDB_G0286169", "Q23924", "DDB_G0284735" ] }, "reaction_10713133": { "compartment": "compartment_6799713", "id": "reaction_10713133", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10713083" ], "products": [ "species_10713131" ], "modifiers": [], "additional_components": [ "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "Q54F59", "DDB_G0291091", "P03967", "DDB_G0292996", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q86A88", "DDB_G0274815", "Q54YE6", "DDB_G0284903", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735", "Q54U62", "DDB_G0281253", "P32252", "DDB_G0292998", "Q54YP0", "DDB_G0278613", "Q553A4", "DDB_G0281401", "Q54U95", "DDB_G0281325", "Q1ZXQ0", "DDB_G0270932", "Q54U08", "DDB_G0281401", "Q55GN5", "DDB_G0267590", "Q86H52", "DDB_G0281401", "Q869V1", "DDB_G0276973", "Q54F44", "DDB_G0291117", "Q75J93", "DDB_G0277381", "Q54LX9", "DDB_G0286315", "Q54GB3", "DDB_G0290363", "P32253", "DDB_G0281385", "Q54F95", "DDB_G0290995", "Q86JN1", "DDB_G0272062", "Q54WR4", "DDB_G0279483", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "Q54F59", "DDB_G0291091", "Q551T0", "DDB_G0281401", "P54642", "DDB_G0274381", "Q54K65", "DDB_G0290995", "Q54VD5", "DDB_G0280437", "Q54QG5", "DDB_G0283893", "P36410", "DDB_G0281337", "Q86GL4", "DDB_G0287101", "Q54CM5", "DDB_G0292814", "Q86J23", "DDB_G0274833", "Q9XYS3", "DDB_G0289653", "Q54YE6", "DDB_G0284903", "Q86A88", "DDB_G0274815", "P32254", "DDB_G0283537", "Q55GA1", "DDB_G0293626", "Q55D50", "DDB_G0269790", "Q867X6", "DDB_G0267460", "Q6TMJ9", "DDB_G0280061", "Q54BH1", "DDB_G0293626", "Q23924", "DDB_G0284735" ] }, "reaction_10686034": { "compartment": "compartment_70101", "id": "reaction_10686034", "reactome": "R-DDI-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674711", "species_10686030" ], "products": [ "species_10686032" ], "modifiers": [], "additional_components": [ "DDB_G0269138", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "P54632", "DDB_G0269138", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686715": { "compartment": "compartment_7660", "id": "reaction_10686715", "reactome": "R-DDI-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450605", "species_10686131" ], "products": [ "species_10686713" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686719": { "compartment": "compartment_7660", "id": "reaction_10686719", "reactome": "R-DDI-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686123", "species_517622" ], "products": [ "species_10686717" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686111": { "compartment": "compartment_7660", "id": "reaction_10686111", "reactome": "R-DDI-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450613", "species_10672405" ], "products": [ "species_10686109" ], "modifiers": [], "additional_components": [ "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337", "Q54WM4", "DDB_G0279549", "Q54HN5", "DDB_G0289337" ] }, "reaction_10686040": { "compartment": "compartment_70101", "id": "reaction_10686040", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10686021", "species_10686036", "species_450597" ], "products": [ "species_10686038" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10686059": { "compartment": "compartment_70101", "id": "reaction_10686059", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685103", "species_10686055", "species_10685110", "species_10685181", "species_10686038" ], "products": [ "species_10686057" ], "modifiers": [], "additional_components": [ "DDB_G0287243", "DDB_G0289921", "DDB_G0283315", "Q54Q83", "DDB_G0284053", "Q7KWX9", "DDB_G0276783", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EU6", "DDB_G0291328", "Q54BH9", "DDB_G0293614", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q54GU2", "DDB_G0289921", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54EU6", "DDB_G0291328", "Q54KM1", "DDB_G0287243", "Q54BH9", "DDB_G0293614", "Q55BB0", "DDB_G0271396", "Q54N99", "DDB_G0285377", "Q54Q83", "DDB_G0284053", "Q55BJ2", "DDB_G0271100", "Q54CU6", "DDB_G0292692", "Q54EV5", "DDB_G0291310", "Q54VM4", "DDB_G0280251", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10699437": { "compartment": "compartment_70101", "id": "reaction_10699437", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10699426" ], "products": [ "species_29370", "species_10699429" ], "modifiers": [ [ "species_10699434", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10699539": { "compartment": "compartment_70101", "id": "reaction_10699539", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699537" ], "products": [ "species_10699479", "species_10699426", "species_10682231" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10699547": { "compartment": "compartment_70101", "id": "reaction_10699547", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699426" ], "products": [ "species_10699491" ], "modifiers": [ [ "species_10676967", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10699508": { "compartment": "compartment_7660", "id": "reaction_10699508", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10684694", "species_10699504" ], "products": [ "species_10699506" ], "modifiers": [], "additional_components": [ "DDB_G0289967", "DDB_G0274577", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10700882": { "compartment": "compartment_70101", "id": "reaction_10700882", "reactome": "R-DDI-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10700878", "species_10674717" ], "products": [ "species_10700880" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "P54632", "DDB_G0269138", "P54632", "DDB_G0269138", "Q54UC1", "DDB_G0281165" ] }, "reaction_10701046": { "compartment": "compartment_7660", "id": "reaction_10701046", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701044" ], "products": [ "species_10701042", "species_10701017", "species_10701036" ], "modifiers": [], "additional_components": [ "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042" ] }, "reaction_10701966": { "compartment": "compartment_70101", "id": "reaction_10701966", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10701961" ], "products": [ "species_10699479", "species_10699426", "species_10682231", "species_10701963" ], "modifiers": [ [ "species_10701961", "catalyst" ] ], "additional_components": [ "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "DDB_G0281165", "DDB_G0268042", "P90532", "DDB_G0288065", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54X15", "DDB_G0279267", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699522": { "compartment": "compartment_7660", "id": "reaction_10699522", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10699510" ], "products": [ "species_113582", "species_10699504" ], "modifiers": [ [ "species_10699519", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "Q553E9", "DDB_G0275845", "Q54ER4", "DDB_G0291380" ] }, "reaction_10701019": { "compartment": "compartment_7660", "id": "reaction_10701019", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10701017" ], "products": [ "species_10699495" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10699497": { "compartment": "compartment_70101", "id": "reaction_10699497", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10699491" ], "products": [ "species_10699495" ], "modifiers": [ [ "species_10674717", "inhibitor" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P54632", "DDB_G0269138" ] }, "reaction_10675699": { "compartment": "compartment_7660", "id": "reaction_10675699", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10675693", "species_10672837" ], "products": [ "species_10675697" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q54LG7", "DDB_G0286645", "Q54XS9", "DDB_G0278769", "Q54V94", "DDB_G0280529", "Q54LG7", "DDB_G0286645", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54XS9", "DDB_G0278769", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q54V94", "DDB_G0280529", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10675695": { "compartment": "compartment_7660", "id": "reaction_10675695", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10672816", "species_10675691" ], "products": [ "species_10675693" ], "modifiers": [], "additional_components": [ "Q55CA3", "DDB_G0270148", "Q54TS6", "DDB_G0281585", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55CA3", "DDB_G0270148", "Q55D17", "DDB_G0269814", "Q54TS6", "DDB_G0281585", "Q54KR9", "DDB_G0287197", "Q54PX4", "DDB_G0284319", "C7G084", "DDB_G0295793", "Q55BS1", "DDB_G0270392", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797" ] }, "reaction_10697903": { "compartment": "compartment_70101", "id": "reaction_10697903", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697893", "species_2534019" ], "products": [ "species_76194", "species_10674265" ], "modifiers": [ [ "species_10697898", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "DDB_G0275863" ] }, "reaction_10674540": { "compartment": "compartment_2514888", "id": "reaction_10674540", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10674512", "catalyst" ], [ "species_10674532", "catalyst" ], [ "species_10674534", "catalyst" ], [ "species_10674536", "inhibitor" ], [ "species_10674530", "inhibitor" ], [ "species_10674538", "inhibitor" ] ], "additional_components": [ "Q553Y7", "DDB_G0275009", "Q03101", "DDB_G0274569", "DDB_G0275931", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10698058": { "compartment": "compartment_70101", "id": "reaction_10698058", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016", "species_10674518" ], "products": [ "species_10674530" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74016", "Q75K28", "DDB_G0275931" ] }, "reaction_10697932": { "compartment": "compartment_70101", "id": "reaction_10697932", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10697913" ], "products": [ "species_10697893", "species_174390" ], "modifiers": [ [ "species_10697929", "catalyst" ] ], "additional_components": [ "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "P34043", "DDB_G0286185", "Q55EP5", "DDB_G0268802", "P34042", "DDB_G0285425", "P34044", "DDB_G0283151", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10685127": { "compartment": "compartment_70101", "id": "reaction_10685127", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685092", "species_429974" ], "products": [ "species_10685094" ], "modifiers": [], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453" ] }, "reaction_10685125": { "compartment": "compartment_70101", "id": "reaction_10685125", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10685094", "species_29356" ], "products": [ "species_10685096", "species_430004" ], "modifiers": [ [ "species_10685122", "catalyst" ] ], "additional_components": [ "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q55EX5", "DDB_G0268716", "Q54KX4", "DDB_G0287053", "Q55F60", "DDB_G0268244", "Q1ZXK3", "DDB_G0277107", "Q54W83", "DDB_G0279837", "Q54HF6", "DDB_G0289499", "Q54HH8", "DDB_G0289453", "Q54R87", "DDB_G0283315", "Q54KM1", "DDB_G0287243", "Q54J96", "DDB_G0288241", "Q54E49", "DDB_G0291804" ] }, "reaction_10683236": { "compartment": "compartment_12045", "id": "reaction_10683236", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683208", "species_113592" ], "products": [ "species_29370", "species_10683233" ], "modifiers": [ [ "species_10683208", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10683169": { "compartment": "compartment_12045", "id": "reaction_10683169", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683158" ], "products": [ "species_10683167" ], "modifiers": [], "additional_components": [ "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10683136": { "compartment": "compartment_70101", "id": "reaction_10683136", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683128" ], "products": [ "species_10683134" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683288": { "compartment": "compartment_12045", "id": "reaction_10683288", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683284" ], "products": [ "species_10683258" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10683246": { "compartment": "compartment_70101", "id": "reaction_10683246", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10673294", "species_113592" ], "products": [ "species_29370", "species_10683243" ], "modifiers": [ [ "species_10683167", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "Q54XD8", "DDB_G0278967", "Q54T27", "DDB_G0282035", "Q869N9", "DDB_G0271862", "C7G083", "DDB_G0295843", "Q55F45", "DDB_G0295843", "Q55DK2", "DDB_G0295843", "Q54R98", "DDB_G0295843" ] }, "reaction_10684272": { "compartment": "compartment_20699", "id": "reaction_10684272", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683264" ], "products": [ "species_10684264", "species_10683128" ], "modifiers": [ [ "species_10684269", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10683278": { "compartment": "compartment_20699", "id": "reaction_10683278", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683258" ], "products": [ "species_10683264", "species_10683270" ], "modifiers": [ [ "species_10683275", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0270252" ] }, "reaction_10683238": { "compartment": "compartment_12045", "id": "reaction_10683238", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10683206" ], "products": [ "species_10683208" ], "modifiers": [], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803", "Q55GJ2", "DDB_G0267650", "Q55DJ9", "DDB_G0269632", "Q559A2", "DDB_G0272987", "Q557G1", "DDB_G0273333", "Q55DJ8", "DDB_G0270894", "Q556Q3", "DDB_G0273171", "Q54IE8", "DDB_G0288803" ] }, "reaction_10682271": { "compartment": "compartment_984", "id": "reaction_10682271", "reactome": "R-DDI-265456", "name": "NPC1L1 binds ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10682267" ], "products": [ "species_10682269" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657", "species_265479", "Q9TVK6", "DDB_G0269158", "Q551C5", "DDB_G0276657" ] }, "reaction_10687765": { "compartment": "compartment_70101", "id": "reaction_10687765", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687761", "species_10687744" ], "products": [ "species_10687763", "species_10687742" ], "modifiers": [], "additional_components": [ "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55DV8", "DDB_G0269510", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q55DV8", "DDB_G0269510", "Q54LJ3", "DDB_G0286797", "Q54NF1", "DDB_G0285295" ] }, "reaction_10718224": { "compartment": "compartment_262783", "id": "reaction_10718224", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718207", "species_10718220", "species_10718215" ], "products": [ "species_10718222" ], "modifiers": [], "additional_components": [ "DDB_G0269238", "DDB_G0269130", "Q86CS2", "DDB_G0292390", "Q54R95", "DDB_G0283337", "Q86CS2", "DDB_G0292390", "P36412", "DDB_G0269238", "O96904", "DDB_G0269130", "Q54R95", "DDB_G0283337" ] }, "reaction_10718103": { "compartment": "compartment_17938", "id": "reaction_10718103", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718076", "species_29356" ], "products": [ "species_10718078", "species_29372" ], "modifiers": [ [ "species_10718076", "catalyst" ], [ "species_10718101", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "CHEBI:15996", "species_29420", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "CHEBI:15996", "Q54WP7", "DDB_G0295717", "Q75JG4", "DDB_G0276119", "C7G032", "DDB_G0295717", "Q553Q2", "DDB_G0295717" ] }, "reaction_10718045": { "compartment": "compartment_24339", "id": "reaction_10718045", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718015" ], "products": [ "species_10718017", "species_29372" ], "modifiers": [ [ "species_10718015", "catalyst" ], [ "species_10718043", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "species_29420", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q54FL2", "DDB_G0290783", "Q55EF0", "DDB_G0269262", "Q8T193", "DDB_G0294569", "Q86JC8", "DDB_G0275955", "Q54E92", "DDB_G0291738", "species_29438", "Q86JP5", "DDB_G0271980", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294569", "Q55EG6", "DDB_G0268910", "Q54S62", "DDB_G0294569", "Q55F14", "DDB_G0269052", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421" ] }, "reaction_10718182": { "compartment": "compartment_5683628", "id": "reaction_10718182", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718176", "species_10718178" ], "products": [ "species_10718180" ], "modifiers": [], "additional_components": [ "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q54IE1", "DDB_G0288811", "Q86CR8", "DDB_G0286191" ] }, "reaction_10718193": { "compartment": "compartment_437051", "id": "reaction_10718193", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718188", "species_29356" ], "products": [ "species_29372", "species_10718190" ], "modifiers": [ [ "species_10718188", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "CHEBI:15996", "Q54DA7", "DDB_G0292406", "species_111349", "Q54DA7", "DDB_G0292406", "CHEBI:15996" ] }, "reaction_10718058": { "compartment": "compartment_19363", "id": "reaction_10718058", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718048", "species_10718054" ], "products": [ "species_10718056" ], "modifiers": [], "additional_components": [ "DDB_G0282977", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q55E78", "DDB_G0275421", "Q553U1", "DDB_G0275421", "Q54RR0", "DDB_G0282977" ] }, "reaction_10718135": { "compartment": "compartment_20699", "id": "reaction_10718135", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718131", "species_10716961" ], "products": [ "species_10718133" ], "modifiers": [], "additional_components": [ "Q54H32", "DDB_G0289735", "Q54KE5", "DDB_G0289735", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "species_29438", "Q54H32", "DDB_G0289735", "Q55FK2", "DDB_G0268068", "Q54KE5", "DDB_G0289735", "species_29438", "Q550W0", "DDB_G0276961", "Q54IZ7", "DDB_G0289735" ] }, "reaction_10687717": { "compartment": "compartment_74700", "id": "reaction_10687717", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687496", "species_113592" ], "products": [ "species_29370", "species_10687276", "species_10687698", "species_10687290", "species_10687285", "species_29372", "species_10687266", "species_10687271" ], "modifiers": [ [ "species_10687714", "catalyst" ] ], "additional_components": [ "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "DDB_G0275573", "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "species_179838", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0287993", "DDB_G0287021", "DDB_G0290087", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q54PT2", "DDB_G0284347", "Q55B11", "DDB_G0271488" ] }, "reaction_10687767": { "compartment": "compartment_70101", "id": "reaction_10687767", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10687763", "species_10687292" ], "products": [ "species_10687496", "species_10687761" ], "modifiers": [], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54RC4", "DDB_G0283203", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54T18", "DDB_G0282045", "P0CG77", "DDB_G0286907", "Q55GD9", "DDB_G0267708", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54P63", "DDB_G0284769", "Q86H98", "DDB_G0275573", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54JK4", "DDB_G0287993", "Q54TK0", "DDB_G0281703", "P0CG78", "DDB_G0289449", "species_179838", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54GK9", "DDB_G0290087", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "Q54P63", "DDB_G0284769", "P0CG77", "DDB_G0286907", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "Q86H98", "DDB_G0275573", "P14794", "DDB_G0280755", "Q54RC4", "DDB_G0283203", "Q54T18", "DDB_G0282045", "Q55GD9", "DDB_G0267708" ] }, "reaction_10718204": { "compartment": "compartment_5683628", "id": "reaction_10718204", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10718199" ], "products": [ "species_10718201", "species_29372" ], "modifiers": [ [ "species_10718199", "catalyst" ], [ "species_10718178", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "species_29420", "O76173", "DDB_G0269174", "O76173", "DDB_G0269174", "species_29438", "DDB_G0288811" ] }, "reaction_10718173": { "compartment": "compartment_17938", "id": "reaction_10718173", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10718163", "species_29356" ], "products": [ "species_10718165", "species_29372" ], "modifiers": [ [ "species_10718163", "catalyst" ], [ "species_10718171", "catalyst" ] ], "additional_components": [ "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "species_111349", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "CHEBI:15996", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "DDB_G0288811" ] }, "reaction_10722615": { "compartment": "compartment_70101", "id": "reaction_10722615", "reactome": "R-DDI-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674492" ], "products": [ "species_10674488", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q54YX3", "DDB_G0278031", "DDB_G0278031" ] }, "reaction_10697511": { "compartment": "compartment_70101", "id": "reaction_10697511", "reactome": "R-DDI-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10674488", "species_30927" ], "products": [ "species_10674490" ], "modifiers": [], "additional_components": [ "DDB_G0278031", "species_30927", "Q54YX3", "DDB_G0278031" ] }, "reaction_10709524": { "compartment": "compartment_70101", "id": "reaction_10709524", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10709517", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] }, "reaction_10709660": { "compartment": "compartment_70101", "id": "reaction_10709660", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10670153", "species_10709521" ], "products": [ "species_10709651" ], "modifiers": [ [ "species_10709657", "catalyst" ] ], "additional_components": [ "Q54TK0", "DDB_G0281703", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG88", "DDB_G0269458", "P0CG77", "DDB_G0286907", "P14797", "DDB_G0276765", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14794", "DDB_G0280755", "DDB_G0279159", "DDB_G0279159", "Q557E4", "DDB_G0273251", "P52285", "DDB_G0269230", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10709669": { "compartment": "compartment_70101", "id": "reaction_10709669", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10709665", "species_10678831" ], "products": [ "species_10709667" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "DDB_G0267384", "Q86KD1", "DDB_G0274167", "Q9XZJ3", "DDB_G0267384" ] }, "reaction_10709519": { "compartment": "compartment_70101", "id": "reaction_10709519", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10709515" ], "products": [ "species_10709517" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10687777": { "compartment": "compartment_74700", "id": "reaction_10687777", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10687774", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10687769": { "compartment": "compartment_74700", "id": "reaction_10687769", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113592", "species_29356" ], "products": [ "species_29370", "species_74722", "species_29372" ], "modifiers": [ [ "species_10674480", "catalyst" ] ], "additional_components": [ "P54641", "DDB_G0273071", "Q55AH5", "DDB_G0271882", "P54648", "DDB_G0284473", "Q86A77", "DDB_G0274331", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "P54642", "DDB_G0274381", "O00780", "DDB_G0275701", "Q76NU1", "DDB_G0277401", "Q54E04", "DDB_G0291858", "Q54Z13", "DDB_G0277971", "Q86AS7", "DDB_G0274141" ] } }, "mod_collapsed_pathways": {}, "degree_dictionary": { "reaction_10677351": 1, "species_10674916": 2, "DDB_G0291332": 2, "reaction_10677345": 1, "species_10674902": 6, "Q869W9": 4, "DDB_G0275069": 1, "Q55E72": 4, "DDB_G0269364": 1, "Q869X2": 4, "DDB_G0275077": 1, "reaction_10677349": 1, "species_10677347": 2, "DDB_G0288387": 3, "reaction_10696321": 3, "species_10696053": 2, "Q54QY4": 93, 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